Recursively cluster

Based on the topic_clustering notebook, we will try with Agglomerative Clustering

import pandas as pd

df = pd.read_csv("downloads/40k_balanced_pm_acl.csv")#.sample(frac=0.5)

!python --version

Python 3.6.13

pos = df[df.labels == 1]


sentences = list(pos["text"]) #otherwise key error

from sentence_transformers import SentenceTransformer, util

print("Encode the corpus ... get a coffee in the meantime")
model = SentenceTransformer('sentence-transformers/all-mpnet-base-v2')
embeddings = model.encode(sentences, batch_size=64, show_progress_bar=True, convert_to_tensor=True)

Encode the corpus ... get a coffee in the meantime

---------------------------------------------------------------------------
NameError                                 Traceback (most recent call last)
<ipython-input-1-d778fc617d7b> in <module>
      3 print("Encode the corpus ... get a coffee in the meantime")
      4 model = SentenceTransformer('sentence-transformers/all-mpnet-base-v2')
----> 5 embeddings = model.encode(sentences, batch_size=64, show_progress_bar=True, convert_to_tensor=True)

NameError: name 'sentences' is not defined

len(embeddings)

from sklearn.cluster import AgglomerativeClustering
import numpy as np

def cluster(embeddings, **kwargs):
    embeddings = embeddings.cpu()
    # Normalize the embeddings to unit length
    corpus_embeddings = embeddings /  np.linalg.norm(embeddings, axis=1, keepdims=True)

    # Perform kmean clustering
    clustering_model = AgglomerativeClustering(**kwargs) #, affinity='cosine', linkage='average', distance_threshold=0.4)
    clustering_model.fit(corpus_embeddings)
   # cluster_assignment = clustering_model.labels_
    return clustering_model

def get_clusters(clustering_model):
    
    clusters = {}
    for sentence_id, cluster_id in enumerate(clustering_model.labels_):
        if cluster_id not in clusters:
            clusters[cluster_id] = []
        try:
            clusters[cluster_id].append(sentences[sentence_id])
        except:
            print(sentence_id, "sentence_id")
    return clusters
   
#     for i, cluster in clustered_sentences.items():
#         print("Cluster ", i+1)
#         print(cluster)
#         print("\n")

sample = embeddings

cluster_model = cluster(sample, n_clusters=None, distance_threshold=1.4)

Cluster Model attributes

nclusters : int The number of clusters found by the algorithm. If distance_threshold=None, it will be equal to the given n_clusters.

labels_
n_leaves_

n_connected_components_ : The estimated number of connected components in the graph.

children_ : array-like of shape (n_samples-1, 2)
    The children of each non-leaf node. Values less than `n_samples`
    correspond to leaves of the tree which are the original samples.
    A node `i` greater than or equal to `n_samples` is a non-leaf
    node and has children `children_[i - n_samples]`. Alternatively
    at the i-th iteration, children[i][0] and children[i][1]
    are merged to form node `n_samples + i`

distances_ : array-like of shape (n_nodes-1,)
    Distances between nodes in the corresponding place in `children_`.
    Only computed if `distance_threshold` is used or `compute_distances`
    is set to `True`.

# ii = itertools.count(sample.shape[0])
# [{'node_id': next(ii), 'left': x[0], 'right':x[1]} for x in cluster_model.children_]

len(get_clusters(cluster_model).keys())

clusters = get_clusters(cluster_model)

import matplotlib.pyplot as plt

for thresh in [1, 1.2, 1.4, 1.8]:
    cluster_model = cluster(sample, n_clusters=None, distance_threshold=thresh)
    plt.hist([len(v) for v in get_clusters(cluster_model).values()], bins='auto', label=str(thresh))
    plt.title("Threshold " + str(thresh))

def collection_to_clusters(texts, model=model,  **kwargs):
    embs = model.encode(texts, batch_size=64, show_progress_bar=True, convert_to_tensor=True)
    cluster_model = cluster(embs, **kwargs)
    return get_clusters(cluster_model).values()

cluster_tree = {}
lens = [len(v) for v in clusters.values()]
for i, v in clusters.items():
    if len(v) > 25:
        cluster_tree[i] = {"parent" : v}
        cluster_tree[i] = {"children" :[*collection_to_clusters(v, n_clusters=None, distance_threshold=0.4)]}
        #get values, embed and sample again with lower threshold

for i,v in cluster_tree.items():
    print(i)
    for sent in v["children"]:
        print(sent)
        print("\n\n")
    print("-------------- \n\n")

Summarization

Tried: Google Pegasus. Result: Does a terrible job of keeping the important information and doesn't retain the question but guesses at a conclusion

torch.cuda.is_available()

Pegasus Setup

from transformers import PegasusForConditionalGeneration, PegasusTokenizer
import torch

model_name = 'google/pegasus-xsum'
device = 'cuda' if torch.cuda.is_available() else 'cpu'
tokenizer = PegasusTokenizer.from_pretrained(model_name)
model = PegasusForConditionalGeneration.from_pretrained(model_name).to(device)

def summarize(sentences):
    batch = tokenizer(sentences, truncation=True, padding='longest', return_tensors="pt").to(device)
    translated = model.generate(**batch)
    tgt_text = tokenizer.batch_decode(translated, skip_special_tokens=True)
    return tgt_text

T5 Setup

from transformers import pipeline

summarizer = pipeline("summarization")

ARTICLE = """ Background: Trust is a critical component of competency committees given their high-stakes decisions. Research from outside of medicine on group trust has not focused on trust in group decisions, and "group trust" has not been clearly defined. The purpose was twofold: to examine the definition of trust in the context of group decisions and to explore what factors may influence trust from the perspective of those who rely on competency committees through a proposed group trust model. Methods: The authors conducted a literature search of four online databases, seeking articles published on trust in group settings. Reviewers extracted, coded, and analyzed key data including definitions of trust and factors pertaining to group trust. Results: The authors selected 42 articles for full text review. Although reviewers found multiple general definitions of trust, they were unable to find a clear definition of group trust and propose the following: a group-directed willingness to accept vulnerability to actions of the members based on the expectation that members will perform a particular action important to the group, encompassing social exchange, collective perceptions, and interpersonal trust. Additionally, the authors propose a model encompassing individual level factors (trustor and trustee), interpersonal interactions, group level factors (structure and processes), and environmental factors."""
from transformers import AutoModelForSeq2SeqLM, AutoTokenizer

model = AutoModelForSeq2SeqLM.from_pretrained("snrspeaks/t5-one-line-summary") #snrspeaks/t5-one-line-summary
tokenizer = AutoTokenizer.from_pretrained("snrspeaks/t5-one-line-summary")

# T5 uses a max_length of 512 so we cut the article to 512 tokens.
inputs = tokenizer.encode("summarize: " + ARTICLE, return_tensors="pt", max_length=512, truncation=True)
outputs = model.generate(inputs, max_length=150, min_length=40, length_penalty=2.0, num_beams=4, early_stopping=True)
tokenizer.decode(outputs[0])
def summarize(text):
    inputs = tokenizer.encode("summarize: " + text, return_tensors="pt", max_length=512, truncation=True)
    outputs = model.generate(inputs, max_length=150, min_length=40, length_penalty=2.0, num_beams=4, early_stopping=True)
    return tokenizer.decode(outputs[0])

summarize("I have seen a ghost in my shed")

"I have seen a ghost in my shed"[:5]

Print Results

for ID, cluster in get_clusters(cluster_model).items():
    sentences = ".".join(cluster)
    print(sentences)
    print( "\n\n", "sum:::", summarize(sentences[:256]), "\n\n\n")

!pip bertopic --version

!pip uninstall bertopic --yes

pip uninstall umap
pip install umap-learn

!pip uninstall bertopic

DEPRECATION: Python 2.7 reached the end of its life on January 1st, 2020. Please upgrade your Python as Python 2.7 is no longer maintained. pip 21.0 will drop support for Python 2.7 in January 2021. More details about Python 2 support in pip can be found at https://pip.pypa.io/en/latest/development/release-process/#python-2-support pip 21.0 will remove support for this functionality.
WARNING: Skipping bertopic as it is not installed.

!pip uninstall numpy --yes

Found existing installation: numpy 1.19.5
Uninstalling numpy-1.19.5:
  Successfully uninstalled numpy-1.19.5

BERTopic topic modeling + set intersection

from bertopic import BERTopic
m = BERTopic(embedding_model='sentence-transformers/all-mpnet-base-v2', calculate_probabilities=True, verbose=True)

topics, probs = m.fit_transform(sentences)

2021-12-03 16:47:33,124 - BERTopic - Transformed documents to Embeddings
2021-12-03 16:48:05,371 - BERTopic - Reduced dimensionality with UMAP
2021-12-03 16:52:37,941 - BERTopic - Clustered UMAP embeddings with HDBSCAN

m.get_topic(0)  # Select the most frequent topic

[('delirium', 0.23893908132663674),
 ('icu', 0.060004499282456554),
 ('intensive', 0.025878934150400382),
 ('hospitalized', 0.021585625161763735),
 ('cognition', 0.016149040019138437),
 ('assessment', 0.013744665868210479),
 ('fluctuating', 0.013594127719910273),
 ('picu', 0.012925099644441015),
 ('reversible', 0.01240616115301262),
 ('caring', 0.011313129457092305)]

m.get_topic(1)  # Select the most frequent topic

[('apnea', 0.18130897695875675),
 ('snoring', 0.06823511579254574),
 ('inspiratory', 0.04325130620318784),
 ('reserpine', 0.027019794584550692),
 ('snore', 0.027019794584550692),
 ('hypopnea', 0.024322723843072304),
 ('respiratory', 0.022186717019186158),
 ('pharmacologic', 0.02162565310159392),
 ('underdiagnosed', 0.020757390256013336),
 ('airways', 0.020047967856036856)]

def extract_topics(texts, distance_thresh=0.035, model=m):
    topic_labels = model.transform(texts)[0]
    topic_dict = {}
    for idx, ID in enumerate(topic_labels):
        topics = model.get_topic(ID)
        for t in topics:
            topic = t[0]
            dist = t[1]
            if dist > distance_thresh:
                if not topic_dict.get(topic):
                    topic_dict[topic] = [ texts[idx] ] 
                else:
                    sents = topic_dict[topic] + [texts[idx]]
                    topic_dict[topic] = sents
    return topic_dict

td = extract_topics(sentences)

td

{'memory': ['Another limitation is that only five predefined realisations of REs were used to elicit object descriptions from the participants',
  'Several scientific psychologists consider the approach for the study of perceptive problems of the Experimental Phenomenology is problematic, namely that the phenomenological demonstrations are subjectively based and they do not produce quantifiable results',
  'An inherent problem with such framing of olfactory objecthood is that philosophers explicitly ignore the constitutive factors of the sensory systems that underpin the implementation of these criteria .',
  "One problem with the concept of habit has been that virtually everyone has their own ideas of what is meant by such a term . Whilst not eschewing folk psychology , it is useful to re-examine dictionary definitions of ' habit ' .",
  "A problem with Graves ' task is that it requires memory searching after stimulus presentation , probably reducing the predicted number of items processed .",
  'The problem with this approach is that the results of such assumptions often lead to conclusions about the production and control of movement that do not relate to the control demands placed on the central nervous system .',
  'One limitation with the way in which these assessments are currently used is that they heavily emphasize reflexive actions without any need to revise automatic postural reactions .',
  'The problem with the concept of duality is that individuals ( need to ) succeed in precise visual tasks upright and should not be more unstable and inefficient - because of a division of attention - in these tasks .',
  'One problem with this approach , however , might be that of retroactive and proactive interference in learning and memory .',
  'The problem with this kind of approach is that it leaves unexplained how the existence of such a detailed internal representation might produce visual consciousness .',
  'A problem with any study in the waking and alert human is that the subject may not be able to completely ignore stimuli , in spite of instructions to do so .',
  'A potential problem with this view is that there exists unambiguous data against the notion that conditioned stimuli ( CSs ) are neutral prior to conditioning .',
  'One problem with this theory is that salient peripheral events , such as offsets , appear to summon attention when used to measure covert attention ( e.g. , the Posner cueing task ) but appear not to elicit oculomotor preparation in tasks that require overt orienting ( e.g. , the remote distractor paradigm ) .',
  'A basic problem with a reliance solely upon a decrease in locomotor activity to measure habituation is that it represents a negative change in behavior .',
  'One problem with the perceptual account is that IOR has not been observed in temporal order judgment .',
  'Retrieval is the use of learned information and represents a big problem in patients with memory deficits where the main issue is that they can learn but can not remember .',
  'One potential problem with this theoretical assumption , however , is that it may violate neurophysiological constraints imposed by the time required to encode visual information , complete some amount of lexical processing , and then program a saccade .',
  'One problem with interpreting these studies is that memory for the contextual stimuli weakens as time passes between the training event and testing and older memories are often less detailed , making it difficult to determine if memory storage in the hippocampus is related to the age or to the accuracy of the memory .',
  'A major drawback of forward inference is its lack of specificity , as it suggests the involvement of brain areas that are not specific for the process/condition under investigation .',
  'A drawback of this approach is a decreasing magnitude of flexion reflex to repeated presentations of the stimuli ( habituation ) .',
  'A major drawback of conventional descriptive profile ( CDP ) in sensory evaluation is the long time spent in panel training .',
  'A possible drawback of this approach is the limited number of stimulus presentations and image acquisitions that are possible in a given period of time , which could result in an inaccurate estimation of effect size ( higher standard error ) .',
  'A major drawback of such tasks is that it is difficult-if not impossible-to separate processes that occur during decision making ( e.g. , response competition ) from processes that take place in the lexicon ( e.g. , lateral inhibition ) .',
  'Extensions to a group-level suffer from the drawback of evaluating single-subject resting-state components of interest either using a predefined spatial template or via visual inspection .',
  'Failures to observe such effects in paradigms involving identical tasks pose a serious problem to the proposal that self-control exhaustion might be reversed by rinsing or ingesting glucose .',
  'Likewise , we readily acknowledge the problems in measuring inhibition that McDowd so clearly documents , but do not feel that this is a fatal problem as long as the inhibitory deficit view continues to be viable within the basic attentional literature , continues to permit the integration of a large body of existing data , and continues to generate new predictions .',
  "Earlier attempts in the first author 's laboratory to find analogous effects of focused attention on the detectability of taste stimuli were equivocal , in part it seems because human gustatory sensitivity can fluctuate substantially over time , a serious problem when using procedures that track sensitivity ( d ' ) to a constant stimulus concentration .",
  'Despite being a fundamental issue for any science of consciousness , its empirical study faces a severe methodological puzzle .',
  'If this figure were true , then false memories would still be a serious problem .',
  'The results ( 1 ) confirm that effective trial-by-trial system switching , although difficult , is possible ; ( 2 ) suggest that switching between tasks mediated by different memory systems is more difficult than switching between two declarative memory tasks ; and ( 3 ) point to a serious shortcoming of current category-learning theories .',
  'The stability of a working memory network is recognized as a serious problem ; stability can be achieved if reverberation is largely mediated by NMDA receptors at recurrent synapses .'],
 'reperfusion': ['Postoperative liver failure is a serious complication after major hepatectomy, and perioperative prediction of its incidence using current technology is still very difficult.',
  'Myocardial ischemia-reperfusion injury (MI-RI) has many adverse complications with high mortality rate',
  'Postresectional liver failure is the most frequent cause of fatal outcome following liver surgery',
  'One problem associated with ABMi therapy is that general anesthesia is required to obtain 400 ml bone marrow fluid from liver cirrhosis patients .',
  'One problem with plasma exchange as supportive therapy in these cases is that massive citrate infusion has an adverse effect on the hepatic energy charge , which may be a serious risk in these patients .',
  'The problem with SPLTx is that it is a very demanding technique applied only in centers with extensive experience with liver resection and reduction .',
  'A drawback of pre-existing in vitro models is that since susceptibility to ischemic injury is age-dependent ; neuroprotection is being studied in neurons that have intrinsic resistance to oxygen-glucose deprivation ( OGD ) .',
  'Laparoscopic surgery and robotic surgery have solved the issue of large incisions , which used to be a major drawback of open liver surgery ; however , further improvements are required in order to achieve the level of safety and accuracy observed during open liver resection when performing all minimally invasive procedures .',
  'Limited coverage of the brain in the z-axis has been a drawback of perfusion CT .',
  'A major drawback of allogeneic hepatocyte transplantation is the lack of sustained survival of the transplanted cells in the recipient liver parenchyma .',
  'Although ischemic postconditioning ( IPost ) confers cardioprotection by protecting the mitochondria though the activation of phosphatidylinositol 3-kinase ( PI3 K ) , a potential drawback of IPost is impairment of aerobic ATP generation during reperfusion by repeated ischemia .',
  "A major drawback of the perfusion of blood through livers was a considerable decrease in the primates ' haemoglobin and platelet levels .",
  'Ischemia-reperfusion injury ( IRI ) is a severe problem \xa0 patients diagnosed with acute limb ischemia .',
  'The demand for clinical use of hepatocytes is escalating because cell transplantation will be an alternative to orthotopic liver transplantation and the shortage of liver donors is a serious problem throughout the world .',
  'Reperfusion injury is a serious problem in ischemic stroke therapy , which leads to neuronal damage and intracranial hemorrhage ( ICH ) .',
  'In living-donor liver transplantation , biliary tract complications are a serious problem for recipients and donors .',
  'Ischemia-reperfusion ( I-R ) injury is a serious problem caused by vascular trauma , tourniquet use and/or compartment syndrome .',
  'Control of blood loss is a serious problem during liver resection .',
  'Hepatic dysfunction in renal transplant recipients : a serious problem .',
  'Liver ischemia and reperfusion injury ( IRI ) remains a serious clinical problem affecting liver transplantation outcomes .',
  'Unfortunately , the cerebral re-perfusion syndrome is still a serious and not completely solved problem .',
  'Liver transplantation has been deemed the best choice for end-stage liver disease patients but immune rejection after surgery is still a serious problem .',
  'Ischemia-reperfusion ( I/R ) injury associated with hepatic resections and liver transplantation remains a serious complication in clinical practice , in spite of several attempts to solve the problem .',
  'PHLF remains a serious problem in patients undergoing major liver resection .',
  'Cardiovascular disease is a serious problem of liver transplant ( LT ) recipients because of increased cardiovascular risk due to immunosuppressive therapy , higher age , intraoperative risk and comorbidities ( such as diabetes and nicotine abuse ) .',
  'Hepatic ischemia-reperfusion ( IR ) injury is a serious clinical problem .',
  'Liver ischemia-reperfusion injury is a serious problem during liver resection and transplantation .',
  'Liver ischemia/reperfusion ( I/R ) injury is a serious clinical problem .',
  'Myocardial ischemia/reperfusion injury is a serious problem involved in cardiovascular diseases .',
  'End-stage liver disease is treated by liver transplantation , but donor organ shortages remain a serious problem .',
  'Ischemia/reperfusion ( I/R ) injury associated with hepatic resections and liver transplantation remains a serious complication in clinical practice , despite several attempts to solve the problem .',
  'Along with the increasing need for living-donor liver transplantation ( LDLT ) , the issue of organ shortage has become a serious problem .',
  'Because it is a severe and complex problem , several studies have been done aiming to elucidate the mechanisms of the ischemic phenomenon and aiming to abolish or to diminish its effects , using drugs that protect the neurons from ischaemia-induced damage .',
  'But despite advances in diagnostic , imaging and surgical techniques , postoperative liver dysfunction of varied severity including death due to liver failure is still a serious problem in such patients .',
  'Ischemia-reperfusion (I/R)-induced organ injury is a serious health problem worldwide , and poor recovery of acute phase injury leads to chronic fibrosis and further organ dysfunction .',
  'Reperfusion injury is a troublesome and unresolved problem in acute myocardial infarction and is believed to be associated with inflammatory reactions in which various types of cells and cytokines participate , in particular , macrophages and monocyte chemoattractant protein-1 ( MCP-1 ) .',
  'Ischemia-reperfusion injury may occur during liver transplantation and remains a serious concern in clinical practice .',
  'is a serious problem that can develop during liver transplantation ( LT ) and is related to morbidities such as insufficient blood supply causing graft dysfunction or impractical closure of the abdominal wall leading to graft compression .',
  'Cell therapy is a potential therapeutic method for cerebral ischemia , which remains a serious problem .',
  'Nowadays , hepatic ischemia reperfusion ( HI/R ) injury is regarded as a serious concern in clinical practices .',
  'Cerebral ischemia/reperfusion injury is a severe problem in patients with brain ischemia .',
  'Orthotopic liver transplantation is now a widely accepted surgical modality for end-stage liver disease , although the shortage of grafts has remained a serious medical and social problem .',
  'Hepatic ischemia reperfusion ( I/R ) injury is regarded as a serious concern in clinical practice .',
  'Hepatic ischemia-reperfusion ( I/R ) injury is a serious concern during hepatic vascular occlusion .',
  'BACKGROUND Cerebral ischemia-reperfusion injury ( CIRI ) remains a serious health problem .',
  'Ischemia-reperfusion ( I/R ) injury of the heart as a consequence of myocardial infarction or cardiac surgery represents a serious clinical problem .',
  'However , the high incidence of tumor metastasis after liver surgery remains a severe problem .',
  'Although liver transplantation offers a chance of cure for patients with advanced liver disease , the shortage and the lack of immediate availability of donors remains a serious problem .',
  'The " territorial belonging " of the middle hepatic vein : a troublesome dilemma in adult live donor liver transplantation -- anatomical evidence based on virtual 3-dimensional-computed tomography-imaging reconstructions .',
  'Domino liver transplantation ( DLT ) has been performed for selected recipients at several centers , but de novo amyloidosis in recipients of livers from patients with familial amyloid polyneuropathy ( FAP ) remains a serious concern .',
  'Ischemia-reperfusion injury is a serious problem .',
  'Hepatic ischemia-reperfusion injury ( I/R ) is a serious health problem associated with liver transplantation , resection surgery , and various types of shock especially hemorrhagic shock .',
  "Vascular insufficiency of the child 's brain is a serious problem because perfusion can be disturbed sufficiently enough to cause permanent brain changes with extensive neurological deficit resulting in some .",
  'Portopulmonary hypertension ( PPHTN ) is a relatively rare complication of end-stage liver disease , and a serious problem in the context of liver transplantation .',
  'Hepatic ischemia reperfusion ( HI/R ) injury may occur during liver transplantation and remains a serious concern in clinical practice .',
  'Hepatic ischemia/reperfusion ( I/R ) injury is a pathologic process caused by hepatic surgery and transplantation , and still remains a severe clinical problem .',
  'The management of ascites is a serious postoperative problem in patients with liver cirrhosis .',
  'Hepatic ischaemia-reperfusion injury is a serious problem that occurs during various surgical operations such as liver transplantation , surgical revascularization , and partial organ resection .',
  'Cerebral ischemia-reperfusion ( IR ) has attracted wide attention as a serious clinical problem .',
  'Ischemia/reperfusion ( I/R ) injury is a serious problem resulting from clinical setting of coronary revascularization .',
  'Ischemia/reperfusion (I/R)-induced oxidative stress is a serious clinical problem in the reperfusion therapy for ischemic diseases .',
  "Cerebral ischemia-reperfusion ( I/R ) injury is also a serious problem for patients ' outcomes .",
  'Confluent hepatic necrosis as well as biliary obstruction were perceived as consequence of a severe perfusion problem in F-M liver transplantation , which was possibly related to an enhancement of ischemia-reperfusion ( I/R ) injury by the lack of estrogen in male recipients of female grafts .',
  'Primary graft dysfunction or nonfunction after liver transplantation , which is usually caused by ischemia/reperfusion injury ( IRI ) , is a serious clinical problem .',
  'However , in Japan , which has a serious problem in the shortage of donor livers , therapies other than transplantation must be further investigated for patients with ALF .',
  'Liver ischemia/reperfusion injury is a severe problem in transplantation , and preservation solutions could be critical for liver viability .',
  'Ischemia/reperfusion damage to the liver remains a serious concern in many clinical situations .',
  'In liver surgery , postoperative liver failure has been a serious problem of concern .',
  'Reperfusion injury is a serious problem after clinical liver transplantation , often leading to dys- or even non-function of grafts .',
  'Liver regeneration after an extensive liver resection is a serious clinical problem , which is difficult to study in detail on patients .',
  'Ischemic reperfusion ( I/R ) injury is a serious problem in the treatment of ischemic heart disease .',
  'Ischemia-reperfusion injury causes oxidative stress producing reactive oxygen species , which is a serious problem linked to morbidity and mortality in liver surgery .',
  'In particularly , hippocampal injury after ischemia-reperfusion is a serious problem as it contributes to vascular dementia .',
  'Ischemia is a serious problem in clinical medicine , and effective methods are needed to detect ischemia before the injury becomes irreversible .',
  'Unfortunately , cerebral re-perfusion syndrome is a serious unresolved problem .',
  'Liver transplantation and hepatocyte transplantation are effective treatments for severe liver injuries , but the donor shortage is a serious problem .',
  'Massive blood transfusion related to the coagulation disorders occurring during the anhepatic and reperfusion phases , remains a serious problem during orthotopic liver transplantation .',
  'In many reconstructive surgical procedures involving microsurgery and prolonged tissue ischemia time , IRI-induced skeletal-muscle injury is a serious clinical concern .',
  'Liver failure due to ischemia-reperfusion injury , believed to be closely related to the generation of oxygen-free radicals , is a serious problem during liver surgery .',
  'Ischemia-reperfusion injury ( IRI ) has been recognized as a serious problem for therapy of cardiovascular diseases .',
  'Inflammatory response that occur post-ischemia is a serious problem in the treatment of ischemic brain disease .'],
 'transplantation': ['Postoperative liver failure is a serious complication after major hepatectomy, and perioperative prediction of its incidence using current technology is still very difficult.',
  'Postresectional liver failure is the most frequent cause of fatal outcome following liver surgery',
  'One problem associated with ABMi therapy is that general anesthesia is required to obtain 400 ml bone marrow fluid from liver cirrhosis patients .',
  'The main problem with cyclosporine is that in many responders proteinuria relapses when the drug is stopped .',
  'One problem with plasma exchange as supportive therapy in these cases is that massive citrate infusion has an adverse effect on the hepatic energy charge , which may be a serious risk in these patients .',
  'The problem with SPLTx is that it is a very demanding technique applied only in centers with extensive experience with liver resection and reduction .',
  'In conclusion , the ability of Tregs to promote the Th17/neutrophil-mediated pathway of rejection that we have described should be considered as a potential drawback of Treg-based cell therapy .',
  'Chemoprophylaxis with trimethoprim/sulphamethoxazole is recommended during the early post-transplantation period , but the optimal duration has not been determined and a main drawback of chemoprophylaxis is the development of resistance of the commensal faecal flora .',
  'Cyclosporine A ( CsA ) is a potent immunosuppressant with the drawback of renal side effects .',
  'Laparoscopic surgery and robotic surgery have solved the issue of large incisions , which used to be a major drawback of open liver surgery ; however , further improvements are required in order to achieve the level of safety and accuracy observed during open liver resection when performing all minimally invasive procedures .',
  'A major drawback of cord blood has been the risk of transfusion reaction secondary to ABO incompatibility and reduction in the stem cell pool if cord blood is manipulated to remove red cells .',
  'A major drawback of allogeneic hepatocyte transplantation is the lack of sustained survival of the transplanted cells in the recipient liver parenchyma .',
  'Delayed hematopoietic recovery is a major drawback of umbilical cord blood ( UCB ) transplantation .',
  'GvHD and infections were the main contributors to a substantial transplant related morbidity and mortality , the major drawback of allogeneic stem cell transplantation .',
  "A major drawback of the perfusion of blood through livers was a considerable decrease in the primates ' haemoglobin and platelet levels .",
  'A major drawback of cord blood has been the risk of transfusion reactions in ABO blood group incompatibility and drastic reduction in the stem cell pool if the cord blood is manipulated to remove red cells prior to cryopreservation or after thawing .',
  'Cyclosporine A ( CsA ) is a potent immunosuppressant with the drawback of renal side-effects .',
  'One child died of a secondary acute rejection resistant to treatment 7 years after the transplantation , 1 has a severe coronary problem 13 years after the transplantation , and three children ( including the diseased child ) have psychomotor development abnormalities .',
  'The demand for clinical use of hepatocytes is escalating because cell transplantation will be an alternative to orthotopic liver transplantation and the shortage of liver donors is a serious problem throughout the world .',
  'Postischemic renal failure is a severe problem following cadaveric renal transplantation , especially if the kidney has been harvested from a non-heartbeating donor , and thereby subjected to periods of both warm and cold ischemia .',
  "The loss or deficiency of a tissue or organ is a serious health problem and severely affects the patients ' quality of life .",
  'Recurrent hepatocellular carcinoma after living donor liver transplantation : a preventable problem or an acceptable risk ?',
  'The organ shortage for transplantation , the principal factor that increases waiting lists , has become a serious public health problem .',
  'Reconstruction of the urinary tract because of ureteral stricture after kidney transplantation is a serious problem .',
  'The persisting organ shortage remains a serious problem .',
  'In living-donor liver transplantation , biliary tract complications are a serious problem for recipients and donors .',
  'Graft loss because of hepatitis C virus recurrence is a serious problem after liver transplantation ( LT ) , and the response to pegylated interferon ( PEG-IFN ) and ribavirin ( RBV ) is poor .',
  'De-novo malignancies continue to be a serious problem after kidney transplantation .',
  'Control of blood loss is a serious problem during liver resection .',
  'Despite significant advances in organ preservation , surgical techniques and perioperative care , primary graft dysfunction is a serious medical problem in transplantation medicine in general and a specific problem in patients undergoing lung transplantation .',
  'While sirolimus ( SRL ) is thought to be a non-nephrotoxic agent , cyclosporine A ( CsA ) toxicity is a serious problem in kidney transplantation .',
  'The detectable rejection process shows that the posterior part of the eye is not absolutely immunologically privileged and that rejection is a serious problem in human retinal transplantation .',
  'Hepatic dysfunction in renal transplant recipients : a serious problem .',
  'Tumor relapses remain a serious problem after allogeneic stem cell transplantation ( alloSCT ) , despite the long-term persistence of minor histocompatibility antigen (MiHA)-specific memory CD8(+ ) T cells specific for the tumor .',
  'Graft rejection is a serious problem despite immunosuppressive agents .',
  'Despite huge progress in transplantation , renal transplantation remains a serious problem since patients treated with the calcineurin inhibitors cyclosporine and tacrolimus are at high risk of developing renal injury .',
  'Liver ischemia and reperfusion injury ( IRI ) remains a serious clinical problem affecting liver transplantation outcomes .',
  'Liver transplantation has been deemed the best choice for end-stage liver disease patients but immune rejection after surgery is still a serious problem .',
  'Antibody-mediated graft rejection caused by donor-specific antibodies ( DSA-MR ) remains a serious problem after heart transplantation ( HTx ) .',
  'Ischemia-reperfusion ( I/R ) injury associated with hepatic resections and liver transplantation remains a serious complication in clinical practice , in spite of several attempts to solve the problem .',
  'Graft loss due to hepatitis C ( HCV ) recurrence is a serious problem after LT .',
  'Hepatitis C virus ( HCV ) recurrence after orthotopic liver transplantation ( OLT ) remains a serious problem in the clinical management of post-oLT patients .',
  'A vexing problem after hematopoietic cell transplantation ( HCT ) for leukemia is assessing the biologic significance of low numbers of cells " suspicious " for relapse seen in morphologic review of peripheral blood smears ( PBSs ) .',
  'Although higher rates of engraftment failure as compared to other stem cell sources after cord blood transplantation ( CBT ) have been a serious concern , the mechanisms underlying these failures have gradually been clarified by analyzing accumulated clinical data , thereby contributing to improvement of engraftment .',
  'PHLF remains a serious problem in patients undergoing major liver resection .',
  'The disproportion between the large organ demand and the low number of transplantations performed represents a serious public health problem worldwide .',
  'There is a severe shortage of human organs available for transplantation and xenotransplantation - use of animal organs has long been suggested to overcome this problem .',
  'De novo malignancies following renal transplantation represent a serious problem endangering the prognosis of otherwise successfully transplanted patients .',
  'However , delayed engraftment , prolonged neutropenia , secondary graft loss , and graft-versus-host disease ( GVHD ) in recipients of cord blood transplantation ( CBT ) make opportunistic infections a serious concern .',
  'Tricuspid regurgitation following heart transplantation can become a severe problem in a subset of patients , where medical therapy fails .',
  'We conclude that HCV infection is a serious health problem among kidney transplant recipients and it significantly affects the graft outcome .',
  'Cardiovascular disease is a serious problem of liver transplant ( LT ) recipients because of increased cardiovascular risk due to immunosuppressive therapy , higher age , intraoperative risk and comorbidities ( such as diabetes and nicotine abuse ) .',
  'Among the various complications of heart transplantation ( HTx ) , the vasculopathy of the allograft ( CAV ) , a phenomenon of chronic rejection , is still a serious problem .',
  'Nephrotoxicity induced by antimicrobial or anticancer drugs is a serious clinical problem .',
  'Hepatic ischemia-reperfusion ( IR ) injury is a serious clinical problem .',
  "Although high-dose chemotherapy with autologous peripheral blood stem cell transplantation ( autoPBSCT ) has been shown or confirmed to be an effective treatment for high-risk and relapsed non-Hodgkin 's lymphoma ( NHL ) , relapse after autoPBSCT remains a serious problem .",
  'In spite of the recent advances in transplantation techniques , donor organ shortage remains a serious problem .',
  'Liver ischemia-reperfusion injury is a serious problem during liver resection and transplantation .',
  'Liver ischemia/reperfusion ( I/R ) injury is a serious clinical problem .',
  'Delayed xenograft rejection remains a serious problem .',
  'Chronic graft rejection mediated by cellular immune responses still poses a serious clinical problem in transplant surgery .',
  'Although 85,000 heart transplantations have been performed worldwide , coronary allograft vasculopathy ( CAV ) , which is a phenomenon of chronic rejection , is still a serious problem .',
  'End-stage liver disease is treated by liver transplantation , but donor organ shortages remain a serious problem .',
  'Ischemia/reperfusion ( I/R ) injury associated with hepatic resections and liver transplantation remains a serious complication in clinical practice , despite several attempts to solve the problem .',
  'Along with the increasing need for living-donor liver transplantation ( LDLT ) , the issue of organ shortage has become a serious problem .',
  'The shortage of organ donors has become a serious problem in modern medicine .',
  'While our experience is of a far lower incidence of rejection than registry data , rejection remains a serious problem after paediatric heart transplantation .',
  'But despite advances in diagnostic , imaging and surgical techniques , postoperative liver dysfunction of varied severity including death due to liver failure is still a serious problem in such patients .',
  'Ischemia-reperfusion injury may occur during liver transplantation and remains a serious concern in clinical practice .',
  'The lack of donor grafts is a severe problem in transplantation medicine .',
  'is a serious problem that can develop during liver transplantation ( LT ) and is related to morbidities such as insufficient blood supply causing graft dysfunction or impractical closure of the abdominal wall leading to graft compression .',
  'Nowadays , hepatic ischemia reperfusion ( HI/R ) injury is regarded as a serious concern in clinical practices .',
  'Despite the availability of potent immunosuppressive drugs , rejection after organ transplantation in children remains a serious concern , and may lead to significant morbidity , graft loss , and death of the patient .',
  'Hemodynamically significant acute graft rejection in pediatric heart transplant recipients is a devastating problem with poor short- and long-term outcomes .',
  'The shortage of human organs for transplantation is a devastating medical problem .',
  'Noncompliance with immunosuppressant therapy is a serious problem that leads to the possibility of graft rejection , even in the long term after liver transplantation .',
  'End-stage allograft failure following cardiac transplantation is a devastating problem , and retransplantation offers the only chance for survival .',
  'Graft coronary artery disease , a serious problem after orthotopic heart transplantation ( OHT ) , has multifactorial etiologies with dyslipidemia as one of the major risk factors .',
  'Cyclosporin A (CyA)-induced nephrotoxicity is still a serious clinical problem .',
  'In hair transplantation , the availability of a limited number of grafts for a conventional transplantation can pose a serious problem .',
  'The shortage of organs and tissues for transplantation is considered a serious global problem .',
  'Orthotopic liver transplantation is now a widely accepted surgical modality for end-stage liver disease , although the shortage of grafts has remained a serious medical and social problem .',
  'Hepatic ischemia reperfusion ( I/R ) injury is regarded as a serious concern in clinical practice .',
  'Hepatic ischemia-reperfusion ( I/R ) injury is a serious concern during hepatic vascular occlusion .',
  'In the liver transplant ( LT ) setting , these regimens are expected to have an important effect , because graft loss due to HCV recurrence is a serious problem after LT .',
  'However , this approach has a serious problem in that donor organs maintain healthy conditions only during short-term storage .',
  'However , acute and chronic rejection still remains a vexing problem for the long term function of the transplanted organ .',
  'The nephrotoxicity of CYA , however , is a serious problem , and constitutes the major obstacle limiting the use of CYA as an immunosuppressive agent for renal transplantation .',
  'However , the high incidence of tumor metastasis after liver surgery remains a severe problem .',
  'Although liver transplantation offers a chance of cure for patients with advanced liver disease , the shortage and the lack of immediate availability of donors remains a serious problem .',
  'This study confirms that infectious toxicity after peripheral blood progenitor cell transplantation is usually moderate , although bacteremia remains a serious problem .',
  'There have been no opportunistic infections , aseptic necrosis or peptic ulcers in this group and cyclosporine nephrotoxicity has not been a serious problem in the pediatric recipients .',
  'Bone loss remains a serious problem after kidney transplantation and is most pronounced during the first months after engraftment .',
  'Establishing fair allocation priorities is a serious problem in organ transplantation .',
  'Urological complications of kidney transplantation remain a serious postoperative problem .',
  'The " territorial belonging " of the middle hepatic vein : a troublesome dilemma in adult live donor liver transplantation -- anatomical evidence based on virtual 3-dimensional-computed tomography-imaging reconstructions .',
  'Tumor relapse after human leukocyte antigen-matched allogeneic stem cell transplantation ( SCT ) remains a serious problem , despite the long-term presence of minor histocompatibility antigen (MiHA)-specific memory T cells .',
  'Shortage of donor organs is a serious problem for transplantation medicine .',
  'Recurrent hepatitis C infection in the posttransplant setting is a serious problem .',
  'Delayed renal allograft function is a serious problem .',
  'Domino liver transplantation ( DLT ) has been performed for selected recipients at several centers , but de novo amyloidosis in recipients of livers from patients with familial amyloid polyneuropathy ( FAP ) remains a serious concern .',
  'Ureteral necrosis is a serious problem in kidney transplantation .',
  'Citrulline levels < 13 micromoles/L should alert the clinical team that a serious problem ( rejection or infection ) could be looming in a previously stable intestinal recipient .',
  'Severe cardiac allograft rejection remains a serious problem despite the advances of cyclosporine-based immunosuppression .',
  'In clinical heart-lung transplantation , reperfusion injury is a serious problem .',
  'Although kidney transplantation was hailed as an optimal solution to such devastating disease , many issues related to immune-suppressive drugs soon emerged and it became evident that cardiovascular disease would remain a vexing problem .',
  'A shortage of organ donors for transplantation has become a serious problem throughout the world .',
  'Hepatic ischemia-reperfusion injury ( I/R ) is a serious health problem associated with liver transplantation , resection surgery , and various types of shock especially hemorrhagic shock .',
  'Inflammatory processes in chronic rejection remain a serious clinical problem in organ transplantation .',
  'Hepatitis C virus ( HCV ) recurrence is a serious problem after orthotopic liver transplantation ( OLT ) .',
  'Acute renal failure is a serious problem following heart transplantation .',
  'Waitlist mortality due to donor shortage for lung transplantation is a serious problem worldwide .',
  'Portopulmonary hypertension ( PPHTN ) is a relatively rare complication of end-stage liver disease , and a serious problem in the context of liver transplantation .',
  'Hepatitis C virus ( HCV ) recurrence after liver transplantation ( LT ) used to be a serious problem in the era of interferon-based treatment .',
  'The small number of organs available for transplant poses a serious problem .',
  'Hepatic ischemia reperfusion ( HI/R ) injury may occur during liver transplantation and remains a serious concern in clinical practice .',
  'Acute graft-versus-host disease ( GVHD ) following allogeneic bone marrow transplantation remains a serious problem .',
  'The exponential increase in the number of patients on the renal transplant waiting list globally has become a serious problem fueled by an increase in the number of patients with end-stage renal disease , the shortage of organs for transplant , and the failure of transplanted kidneys for various reasons .',
  'Morbidity caused by early allograft dysfunction , manifested by a progressive increase in pulmonary vascular resistance and a decrease in oxygenation , remains a serious problem in lung transplantation .',
  'TCAD is a serious problem in transplant recipients and may affect patients of any age , even neonates .',
  'Despite unequivocal success , relapse after transplant remains a serious problem , being the main cause of treatment failure .',
  'A severe problem is the the scarcity of suitable donors for the very low weight children who are candidates for LSBT .',
  'Hepatic ischemia/reperfusion ( I/R ) injury is a pathologic process caused by hepatic surgery and transplantation , and still remains a severe clinical problem .',
  'The lack of an absolute correlation between DSA , crossmatching and outcome presents a serious dilemma for the transplant community .',
  'The management of ascites is a serious postoperative problem in patients with liver cirrhosis .',
  'Hepatic ischaemia-reperfusion injury is a serious problem that occurs during various surgical operations such as liver transplantation , surgical revascularization , and partial organ resection .',
  'However , the recurrence of HCC after transplantation remains a serious problem that affects about 20 % of post-transplant cases .',
  'The immunosuppressive drug tacrolimus ( FK506 ) is used clinically to reduce the rejection rate in patients with kidney transplantation ; however , the resultant nephrotoxicity remains a serious problem .',
  'Polyoma is a serious concern for SPK transplant recipients .',
  'Turkey is one of the countries facing a serious organ shortage problem , with thousands of patients with end-stage organ failure .',
  'A severe shortage of suitable allografts is a long-standing and worldwide problem for patients who are waiting for organ transplantation .',
  'However , the development of malignancies after transplantation is a serious problem .',
  'To date , however , no study has provided any psychosocial follow-up of donors who developed a serious health problem such as end-stage renal disease ( ESRD ) .',
  'However , the shortage of donor skin tissues is a serious problem .',
  'However , when a severe health problem occurs in a donor while the recipient has already received a conditioning regimen , hematologists have to find the best solutions for the recipient , while the team in charge of the donor has to find the best medical solutions for the donor .',
  'Relapses after autologous transplantation are a serious clinical problem in patients with haematological diseases .',
  'Although the higher rate of engraftment failure remains a serious concern after cord blood transplantation ( CBT ) , the mechanisms underlying this risk have gradually been clarified , which has helped to improve engraftment .',
  'A shortage of donors poses a serious problem for organ transplantation around the world .',
  'Confluent hepatic necrosis as well as biliary obstruction were perceived as consequence of a severe perfusion problem in F-M liver transplantation , which was possibly related to an enhancement of ischemia-reperfusion ( I/R ) injury by the lack of estrogen in male recipients of female grafts .',
  'It is concluded that the development of obstructive airway disease represents a serious problem in all types of lung transplantation .',
  'Allograft rejection is a serious concern in heart transplant medicine .',
  'Primary graft dysfunction or nonfunction after liver transplantation , which is usually caused by ischemia/reperfusion injury ( IRI ) , is a serious clinical problem .',
  'In transplant recipients , nephrotoxicity due to long-term use of calcineurin inhibitor ( CNI ) is a serious problem that can not be overlooked .',
  'However , in Japan , which has a serious problem in the shortage of donor livers , therapies other than transplantation must be further investigated for patients with ALF .',
  'We believe that immunosuppression-induced pneumonitis in a lung allograft is a serious dilemma for lung transplant physicians',
  'However , the imbalance between the supply and the demand for human organs is a serious problem in modern transplantology .',
  'The recent increase of the number of unidentified cadavers has become a serious problem throughout the world .',
  'However , graft rejection is a severe problem with clinical small bowel transplantation , because small intestinal wall contains large amounts of lymphoid tissue .',
  'However , the nephrotoxicity induced by FK506 remains a serious clinical problem .',
  'Hepatitis C recurrence after liver transplantation is a serious problem , leading to increased graft loss and morbidity in some individuals .',
  'For renal transplant recipient treated with ICIs , the increased incidence of rejection is a serious concern .',
  'Liver ischemia/reperfusion injury is a severe problem in transplantation , and preservation solutions could be critical for liver viability .',
  'Renal failure after heart transplantation ( HTx ) still remains a serious problem , especially when cyclosporin A is used for immunosuppression in the early postoperative therapy .',
  'Primary graft dysfunction remains a serious problem after heart transplant .',
  'Since the advent of bone marrow transplantation , a vexing clinical problem is that of acute graft-vs-host disease ( GVHD ) .',
  'Ischemia/reperfusion damage to the liver remains a serious concern in many clinical situations .',
  'The nephrotoxicity induced by immunosuppressant FK506 remains a serious clinical problem , and the underlying mechanism has not been completely understood .',
  'With new immunosuppressive agents the incidence of acute rejection has been significantly reduced , but infection has become a serious problem .',
  'In liver surgery , postoperative liver failure has been a serious problem of concern .',
  'The shortage of organ donors is a serious problem in Japan .',
  'Allograft loss remains a severe clinical problem after kidney transplantation .',
  'Reperfusion injury is a serious problem after clinical liver transplantation , often leading to dys- or even non-function of grafts .',
  'The prevalence of end-stage renal disease is emerging as a serious worldwide public health problem because of the shortage of donor organs and the need to take lifelong immunosuppressive medication in patients who receive a transplanted kidney .',
  'PVAN was the leading cause of renal loss in SPK patients in the first 2 years after transplantation and is a serious concern for SPK recipients .',
  'Liver regeneration after an extensive liver resection is a serious clinical problem , which is difficult to study in detail on patients .',
  'Graft rejection remains a serious problem in patients transplanted for severe aplastic anemia .',
  'Cyclosporin has improved graft survival after renal transplantation , but cyclosporin nephrotoxicity is a severe clinical problem .',
  'Ischemia-reperfusion injury causes oxidative stress producing reactive oxygen species , which is a serious problem linked to morbidity and mortality in liver surgery .',
  'The shortage of donors has become a serious problem .',
  'Drug nephrotoxicity is a serious health and economic problem worldwide .',
  'Liver transplantation and hepatocyte transplantation are effective treatments for severe liver injuries , but the donor shortage is a serious problem .',
  'Massive blood transfusion related to the coagulation disorders occurring during the anhepatic and reperfusion phases , remains a serious problem during orthotopic liver transplantation .',
  'Liver failure due to ischemia-reperfusion injury , believed to be closely related to the generation of oxygen-free radicals , is a serious problem during liver surgery .',
  'In lung transplantation , reimplantation response is still a serious problem .',
  'Although 100,000 cardiac transplants have been performed , coronary allograft vasculopathy ( CAV ) , which is a phenomenon of chronic rejection , is still a serious problem .',
  'Delayed recovery of mature blood cells poses a serious , expensive , and often life-threatening problem for many stem cell transplantation recipients , particularly if heavily pretreated and serving as their own donor , or having a CB transplantation as the only therapeutic option .',
  'Malignant tumors represent a serious problem in transplantation medicine .',
  'Organ shortages are a serious problem , even in the United States .',
  'Allograft rejection continues to be a vexing problem in clinical lung transplantation , and the role played by passenger leukocytes in the rejection or acceptance of an organ is unclear .',
  'Post-transplant renal osteopathy ( ROP ) remains a serious problem , which contributes to substantial long-term morbidity of the graft recipients .',
  'Severe bacterial infections are a serious problem after cord blood transplantation ( CBT ) .',
  'Recurrent hepatitis C after liver transplantation is a serious problem faced by liver transplant recipients .',
  'In organ allotransplantation represents a serious problem acute rejection , which is the reaction of recipient organism aimed to reject the transplanted organ .',
  'Recurrent hepatitis C virus ( HCV ) has been a serious problem after liver transplantation ( LT ) .',
  'To increase the number of available pulmonary grafts , we have tried various strategies , such as active use of marginal donors , careful donor management , and development of new preservation solutions , but the shortage of brain-dead donors remains a serious problem .',
  'Acute tubular necrosis ( ATN ) represents a serious problem in kidney transplantation .'],
 'hepatic': ['Postoperative liver failure is a serious complication after major hepatectomy, and perioperative prediction of its incidence using current technology is still very difficult.',
  'people with alcohol-related liver disease require complex treatment plans that often include the need for medication for the rest of their lives.',
  'Postresectional liver failure is the most frequent cause of fatal outcome following liver surgery',
  'One problem associated with ABMi therapy is that general anesthesia is required to obtain 400 ml bone marrow fluid from liver cirrhosis patients .',
  'Another important problem associated with NASH is that presently the liver biopsy is still the gold standard in diagnosis and for disease staging and grading .',
  'However , the problem with BALs is that it is difficult to find a source of healthy hepatic cells with good liver function .',
  'One problem with plasma exchange as supportive therapy in these cases is that massive citrate infusion has an adverse effect on the hepatic energy charge , which may be a serious risk in these patients .',
  'The problem with SPLTx is that it is a very demanding technique applied only in centers with extensive experience with liver resection and reduction .',
  'Laparoscopic surgery and robotic surgery have solved the issue of large incisions , which used to be a major drawback of open liver surgery ; however , further improvements are required in order to achieve the level of safety and accuracy observed during open liver resection when performing all minimally invasive procedures .',
  'A major drawback of allogeneic hepatocyte transplantation is the lack of sustained survival of the transplanted cells in the recipient liver parenchyma .',
  "A major drawback of the perfusion of blood through livers was a considerable decrease in the primates ' haemoglobin and platelet levels .",
  'Infection remains a drawback of parenteral nutrition ( PN ) , probably related , among other factors , to immunosuppressive effects of its lipid component .',
  'The lack of sensitivity to detect fibrosis , because of its heterogeneity is a drawback of liver biopsy ( LB ) .',
  'The demand for clinical use of hepatocytes is escalating because cell transplantation will be an alternative to orthotopic liver transplantation and the shortage of liver donors is a serious problem throughout the world .',
  'Liver fibrosis is a serious health problem worldwide , which can be induced by a wide spectrum of chronic liver injuries .',
  'Hepatic encephalopathy is a serious problem in patients with liver cirrhosis and precise pathophysiological mechanisms responsible for encephalopathy are not fully understood .',
  'Therefore , protection from the injury of hepatocytes and liver is a serious concern in various clinical settings .',
  'In living-donor liver transplantation , biliary tract complications are a serious problem for recipients and donors .',
  'Liver disease is a serious problem .',
  'Liver fibrosis is a severe health problem , threatening the life quality and causing death , raising great concerns worldwide .',
  'Hepatic abscess is a serious surgical problem with a high mortality rate .',
  'Acute liver failure ( ALF ) remains a serious problem in critical care with a high rate of mortality .',
  'Liver fibrosis is a severe health problem worldwide , and it is characterized by the activation of hepatic stellate cells ( HSCs ) and excessive deposition of collagen .',
  'Control of blood loss is a serious problem during liver resection .',
  'Chronic liver disorders represent a serious health problem .',
  'Liver injuries have been a serious public health problem worldwide .',
  'Hepatic dysfunction in renal transplant recipients : a serious problem .',
  'Liver ischemia and reperfusion injury ( IRI ) remains a serious clinical problem affecting liver transplantation outcomes .',
  'Liver transplantation has been deemed the best choice for end-stage liver disease patients but immune rejection after surgery is still a serious problem .',
  'Ischemia-reperfusion ( I/R ) injury associated with hepatic resections and liver transplantation remains a serious complication in clinical practice , in spite of several attempts to solve the problem .',
  'However , Fas mediated liver and chondrocyte damage is a serious problem in its clinical application .',
  'The not well known parenteral nutrition-related liver disease is a serious problem associated to short bowel and long-term parenteral nutrition ( PN ) use , and BT is also frequent in those patients .',
  'Liver disease is a serious problem affecting millions of people with continually increasing prevalence .',
  'PHLF remains a serious problem in patients undergoing major liver resection .',
  'Liver diseases are on rise and remain a serious health problem .',
  'Cardiovascular disease is a serious problem of liver transplant ( LT ) recipients because of increased cardiovascular risk due to immunosuppressive therapy , higher age , intraoperative risk and comorbidities ( such as diabetes and nicotine abuse ) .',
  'Cirrhosis of the liver is a serious public health problem worldwide , with regional variations determined by cultural factors and economic development .',
  'Hepatic sickness is a serious problem for human health .',
  'Hepatic ischemia-reperfusion ( IR ) injury is a serious clinical problem .',
  'Liver ischemia-reperfusion injury is a serious problem during liver resection and transplantation .',
  'Liver ischemia/reperfusion ( I/R ) injury is a serious clinical problem .',
  'Fulminant liver failure ( FHF ) is a serious clinical problem and liver transplantation is the major intervention .',
  'End-stage liver disease is treated by liver transplantation , but donor organ shortages remain a serious problem .',
  'Ischemia/reperfusion ( I/R ) injury associated with hepatic resections and liver transplantation remains a serious complication in clinical practice , despite several attempts to solve the problem .',
  'Along with the increasing need for living-donor liver transplantation ( LDLT ) , the issue of organ shortage has become a serious problem .',
  'But despite advances in diagnostic , imaging and surgical techniques , postoperative liver dysfunction of varied severity including death due to liver failure is still a serious problem in such patients .',
  'Ischemia-reperfusion injury may occur during liver transplantation and remains a serious concern in clinical practice .',
  'is a serious problem that can develop during liver transplantation ( LT ) and is related to morbidities such as insufficient blood supply causing graft dysfunction or impractical closure of the abdominal wall leading to graft compression .',
  'Liver cirrhosis , which is caused by the accumulation of extracellular matrix materials , is a serious clinical problem that can progress to hepatic failure .',
  'Nowadays , hepatic ischemia reperfusion ( HI/R ) injury is regarded as a serious concern in clinical practices .',
  'Liver fibrosis is a serious health problem which may lead to advanced liver cirrhosis and hepatocellular carcinoma .',
  'Orthotopic liver transplantation is now a widely accepted surgical modality for end-stage liver disease , although the shortage of grafts has remained a serious medical and social problem .',
  'Hepatic ischemia reperfusion ( I/R ) injury is regarded as a serious concern in clinical practice .',
  'Hepatic ischemia-reperfusion ( I/R ) injury is a serious concern during hepatic vascular occlusion .',
  'Liver disease , involving a wide range of liver pathologies from fatty liver , hepatitis , and fibrosis to cirrhosis and hepatocellular carcinoma , is a serious health problem worldwide .',
  'Hepatic cirrhosis is a serious clinical problem caused by the accumulation of extracellular matrix , which can ultimately progress into hepatic failure .',
  'Fibrosis remains a serious health concern in patients with chronic liver disease .',
  'However , the high incidence of tumor metastasis after liver surgery remains a severe problem .',
  'Although liver transplantation offers a chance of cure for patients with advanced liver disease , the shortage and the lack of immediate availability of donors remains a serious problem .',
  'Liver failure is a serious problem that affects thousands of people in the United States each year .',
  'The " territorial belonging " of the middle hepatic vein : a troublesome dilemma in adult live donor liver transplantation -- anatomical evidence based on virtual 3-dimensional-computed tomography-imaging reconstructions .',
  'The development of hepatic encephalopathy and coma hepaticum in patients with acute gastrointestinal bleeding and hepatic cirrhosis is a serious problem .',
  'Chemical liver and kidney injury have become a serious concern to human .',
  'Domino liver transplantation ( DLT ) has been performed for selected recipients at several centers , but de novo amyloidosis in recipients of livers from patients with familial amyloid polyneuropathy ( FAP ) remains a serious concern .',
  '[ Apropos of a fatal and delirious acute hepatitis . Current physiopathological therapeutic considerations ] .',
  'Alcoholic liver disease ( ALD ) is a serious health problem with significant morbidity and mortality .',
  'Liver injury or dysfunction is considered as a serious health problem .',
  'Based on the experimental findings , it was indicated that the ethanol evaporation from culture plates was a severe problem reducing its toxicity in hepatocyte .',
  'Hepatic ischemia-reperfusion injury ( I/R ) is a serious health problem associated with liver transplantation , resection surgery , and various types of shock especially hemorrhagic shock .',
  'Liver failure ( LF ) continues to be a serious problem due to different underlying disorders .',
  'Acute liver failure is a severe liver disorder that poses considerable global challenges .',
  'Acute fulminant liver failure is a serious worldwide health problem .',
  'Portopulmonary hypertension ( PPHTN ) is a relatively rare complication of end-stage liver disease , and a serious problem in the context of liver transplantation .',
  'Liver fibrosis is a serious health problem which is a critical cause of morbidity and mortality worldwide .',
  'Hepatic ischemia reperfusion ( HI/R ) injury may occur during liver transplantation and remains a serious concern in clinical practice .',
  'Liver damage through prolonged intake of high amounts of alcohol is a serious problem that affects many members of the population .',
  'Alcoholic hepatitis is a serious clinical problem ; opportune detection is transcendental for treatment and survival improvement .',
  'Hepatic ischemia/reperfusion ( I/R ) injury is a pathologic process caused by hepatic surgery and transplantation , and still remains a severe clinical problem .',
  'Chronic liver disorders represent a serious health problem , considering that 300 million people worldwide are hepatitis B virus carriers , and 8,000 - 10,000 patients per year , in the U.S. alone , die as a result of liver failure caused by hepatitis C infection .',
  'Pyogenic liver abscess , having experienced an evolving pathogenesis over the years , still remains a serious problem with significant morbidity .',
  'The management of ascites is a serious postoperative problem in patients with liver cirrhosis .',
  'Hepatic ischaemia-reperfusion injury is a serious problem that occurs during various surgical operations such as liver transplantation , surgical revascularization , and partial organ resection .',
  'Chronic liver diseases are a serious health problem worldwide .',
  'However , liver fibrosis remains a serious medical concern , potentially progressing to end-stage liver cirrhosis and even death .',
  'Subclinical hepatic encephalopathy ( SHE ) is a serious clinical problem in patiens with liver damage and precise pathophisiological mechanisms resonsible for encephalopathy are not fully understood .',
  'Pyogenic liver abscess is a serious clinical problem associated with severe complications in 10 - 20 % of cases .',
  'Chronic liver disease has gradually become a serious health problem worldwide .',
  'End-stage organ failure is a devastating problem with limited therapeutic options .',
  'Confluent hepatic necrosis as well as biliary obstruction were perceived as consequence of a severe perfusion problem in F-M liver transplantation , which was possibly related to an enhancement of ischemia-reperfusion ( I/R ) injury by the lack of estrogen in male recipients of female grafts .',
  'Primary graft dysfunction or nonfunction after liver transplantation , which is usually caused by ischemia/reperfusion injury ( IRI ) , is a serious clinical problem .',
  'However , in Japan , which has a serious problem in the shortage of donor livers , therapies other than transplantation must be further investigated for patients with ALF .',
  'Hepatic foci are a serious economic problem for most turkey-producing areas in the United States .',
  'Liver ischemia/reperfusion injury is a severe problem in transplantation , and preservation solutions could be critical for liver viability .',
  'Chronic hepatitis is a serious problem because the disease seems to be progressive despite prednisone therapy .',
  'The prevalence of various hepatic diseases increases dramatically worldwide and regarded as a serious health problem .',
  'Chronic liver disease is a serious global health problem , and an increasing number of patients are seeking alternative medicines or complementary treatment .',
  'Ischemia/reperfusion damage to the liver remains a serious concern in many clinical situations .',
  '[ Apropos of a fatal and deliriant form of acute hepatitis . Physiopathological considerations . Current therapy ] .',
  'Alcoholic liver disease ( ALD ) is a serious liver problem in western countries .',
  'In liver surgery , postoperative liver failure has been a serious problem of concern .',
  'Acute liver failure is a serious clinical problem of which the underlying pathogenesis remains unclear and for which effective therapies are lacking .',
  'Reperfusion injury is a serious problem after clinical liver transplantation , often leading to dys- or even non-function of grafts .',
  'Liver regeneration after an extensive liver resection is a serious clinical problem , which is difficult to study in detail on patients .',
  'Ischemia-reperfusion injury causes oxidative stress producing reactive oxygen species , which is a serious problem linked to morbidity and mortality in liver surgery .',
  'Liver damage is a serious medical problem worldwide and is caused by primary or secondary metabolic , microbiological , toxicological , immunological and circulatory etiological factors .',
  'Acute hepatic failure is a serious problem .',
  'Intestinal failure-associated liver disease ( IFALD ) remains a serious problem in the treatment of infants with nutritional problems and short bowel syndrome .',
  'Liver transplantation and hepatocyte transplantation are effective treatments for severe liver injuries , but the donor shortage is a serious problem .',
  'Massive blood transfusion related to the coagulation disorders occurring during the anhepatic and reperfusion phases , remains a serious problem during orthotopic liver transplantation .',
  'Liver failure due to ischemia-reperfusion injury , believed to be closely related to the generation of oxygen-free radicals , is a serious problem during liver surgery .',
  'Chronic liver dysfunction or injury is a serious health problem worldwide .',
  'Human liver cancer has emerged as a serious health concern in the world , associated with poorly available therapies .',
  'Parenteral nutrition-associated liver disease remains a vexing problem .',
  'As a serious public health concern , alcohol-related liver disease is associated with dysregulations in the intestinal barrier function and the gut microbiota .',
  'Hepatic abscess ( HA ) remains a serious and often difficult to diagnose problem .',
  'Evidence that progressive liver injury develops in some patients requiring lifelong total parenteral nutrition raises a serious dilemma for both patients and physicians .',
  'Amoebic liver abscess is a serious problem in Pakistan .',
  'Protein and energy malnutrition is a severe problem for patients with liver cirrhosis ( LC ) and fasting often induces starvation which is a vitally important outcome .'],
 'ischemia': ['Postoperative liver failure is a serious complication after major hepatectomy, and perioperative prediction of its incidence using current technology is still very difficult.',
  'Prolonged immobility in the sitting position in the elderly is known to produce venous stasis with leg edema and possible skin changes.',
  'Kawasaki disease (KD) is an acute febrile systemic vasculitis that affects small and medium blood vessels',
  'Myocardial ischemia-reperfusion injury (MI-RI) has many adverse complications with high mortality rate',
  'Postresectional liver failure is the most frequent cause of fatal outcome following liver surgery',
  'Takayasu arteritis (TA) is a chronic inflammatory disease that induces stenosis, occlusion, or aneurysmal degeneration of the aorta and its major branches',
  'One problem associated with ABMi therapy is that general anesthesia is required to obtain 400 ml bone marrow fluid from liver cirrhosis patients .',
  'One problem with plasma exchange as supportive therapy in these cases is that massive citrate infusion has an adverse effect on the hepatic energy charge , which may be a serious risk in these patients .',
  'The problem with SPLTx is that it is a very demanding technique applied only in centers with extensive experience with liver resection and reduction .',
  'A drawback of pre-existing in vitro models is that since susceptibility to ischemic injury is age-dependent ; neuroprotection is being studied in neurons that have intrinsic resistance to oxygen-glucose deprivation ( OGD ) .',
  'Laparoscopic surgery and robotic surgery have solved the issue of large incisions , which used to be a major drawback of open liver surgery ; however , further improvements are required in order to achieve the level of safety and accuracy observed during open liver resection when performing all minimally invasive procedures .',
  'Limited coverage of the brain in the z-axis has been a drawback of perfusion CT .',
  'A major drawback of allogeneic hepatocyte transplantation is the lack of sustained survival of the transplanted cells in the recipient liver parenchyma .',
  'Although ischemic postconditioning ( IPost ) confers cardioprotection by protecting the mitochondria though the activation of phosphatidylinositol 3-kinase ( PI3 K ) , a potential drawback of IPost is impairment of aerobic ATP generation during reperfusion by repeated ischemia .',
  "A major drawback of the perfusion of blood through livers was a considerable decrease in the primates ' haemoglobin and platelet levels .",
  'Ischemia-reperfusion injury ( IRI ) is a severe problem \xa0 patients diagnosed with acute limb ischemia .',
  'Diagnosis and therapy of mesenteric ischaemia as the cause of an acute abdomen is a serious problem because of its 60 - 80 % mortality .',
  'The demand for clinical use of hepatocytes is escalating because cell transplantation will be an alternative to orthotopic liver transplantation and the shortage of liver donors is a serious problem throughout the world .',
  'Reperfusion injury is a serious problem in ischemic stroke therapy , which leads to neuronal damage and intracranial hemorrhage ( ICH ) .',
  'In living-donor liver transplantation , biliary tract complications are a serious problem for recipients and donors .',
  'Ischemia-reperfusion ( I-R ) injury is a serious problem caused by vascular trauma , tourniquet use and/or compartment syndrome .',
  'Control of blood loss is a serious problem during liver resection .',
  '[ Acute mesenteric ischemia : a severe problem in digestive pathology ] .',
  'Hepatic dysfunction in renal transplant recipients : a serious problem .',
  'Intestinal ischemia-reperfusion injury is a serious and widespread clinical problem .',
  'Liver ischemia and reperfusion injury ( IRI ) remains a serious clinical problem affecting liver transplantation outcomes .',
  'Unfortunately , the cerebral re-perfusion syndrome is still a serious and not completely solved problem .',
  'Liver transplantation has been deemed the best choice for end-stage liver disease patients but immune rejection after surgery is still a serious problem .',
  'Injury to the intestinal mucosa is a life-threatening problem in a variety of clinical disorders , including hemorrhagic shock , trauma , burn , pancreatitis , and heat stroke .',
  'Digital ischemia is a serious problem in peripheral artery diseases ( PAD ) patients .',
  'Ischemia-reperfusion ( I/R ) injury associated with hepatic resections and liver transplantation remains a serious complication in clinical practice , in spite of several attempts to solve the problem .',
  'PHLF remains a serious problem in patients undergoing major liver resection .',
  'Cardiovascular disease is a serious problem of liver transplant ( LT ) recipients because of increased cardiovascular risk due to immunosuppressive therapy , higher age , intraoperative risk and comorbidities ( such as diabetes and nicotine abuse ) .',
  'Hepatic ischemia-reperfusion ( IR ) injury is a serious clinical problem .',
  'Peripheral artery disease ( PAD ) is becoming a serious health problem of present times .',
  'Liver ischemia-reperfusion injury is a serious problem during liver resection and transplantation .',
  'Liver ischemia/reperfusion ( I/R ) injury is a serious clinical problem .',
  'Myocardial ischemia/reperfusion injury is a serious problem involved in cardiovascular diseases .',
  'Intestinal ischemia-reperfusion ( I/R ) injury is a life-threatening vascular emergency and has long been a disturbing problem for surgeons .',
  'Acute mesenteric ischemia is highly lethal and therefore a serious problem for surgery and intensive care medicine ; accordingly its pathophysiology warrants further study .',
  'End-stage liver disease is treated by liver transplantation , but donor organ shortages remain a serious problem .',
  'Ischemia/reperfusion ( I/R ) injury associated with hepatic resections and liver transplantation remains a serious complication in clinical practice , despite several attempts to solve the problem .',
  'Along with the increasing need for living-donor liver transplantation ( LDLT ) , the issue of organ shortage has become a serious problem .',
  'Because it is a severe and complex problem , several studies have been done aiming to elucidate the mechanisms of the ischemic phenomenon and aiming to abolish or to diminish its effects , using drugs that protect the neurons from ischaemia-induced damage .',
  'But despite advances in diagnostic , imaging and surgical techniques , postoperative liver dysfunction of varied severity including death due to liver failure is still a serious problem in such patients .',
  'Ischemia-reperfusion (I/R)-induced organ injury is a serious health problem worldwide , and poor recovery of acute phase injury leads to chronic fibrosis and further organ dysfunction .',
  'Reperfusion injury is a troublesome and unresolved problem in acute myocardial infarction and is believed to be associated with inflammatory reactions in which various types of cells and cytokines participate , in particular , macrophages and monocyte chemoattractant protein-1 ( MCP-1 ) .',
  'Ischemia-reperfusion injury may occur during liver transplantation and remains a serious concern in clinical practice .',
  'is a serious problem that can develop during liver transplantation ( LT ) and is related to morbidities such as insufficient blood supply causing graft dysfunction or impractical closure of the abdominal wall leading to graft compression .',
  'Cell therapy is a potential therapeutic method for cerebral ischemia , which remains a serious problem .',
  'Nowadays , hepatic ischemia reperfusion ( HI/R ) injury is regarded as a serious concern in clinical practices .',
  'Intestinal ischaemia with ensuing gangrene has been a serious clinical problem .',
  'In an aging population vascular disorders well exemplified by the chronic limb ischemia , chronic heart failure , cerebral ischemia and age-related macular degeneration represent a serious medical and socio-economical problem .',
  'Acute mesenteric ischemia is a serious problem with high morbidity and mortality rates .',
  'Ischemia-reperfusion ( IR ) injury of the small intestine is a serious problem in abdominal aortic aneurysm surgery or small intestine transplantation .',
  'Cerebral ischemia/reperfusion injury is a severe problem in patients with brain ischemia .',
  'Orthotopic liver transplantation is now a widely accepted surgical modality for end-stage liver disease , although the shortage of grafts has remained a serious medical and social problem .',
  'Hepatic ischemia reperfusion ( I/R ) injury is regarded as a serious concern in clinical practice .',
  'Hepatic ischemia-reperfusion ( I/R ) injury is a serious concern during hepatic vascular occlusion .',
  'BACKGROUND Cerebral ischemia-reperfusion injury ( CIRI ) remains a serious health problem .',
  'Intestinal ischaemia-reperfusion ( II/R ) injury is a serious clinical problem .',
  'Ischemia-reperfusion ( I/R ) injury of the heart as a consequence of myocardial infarction or cardiac surgery represents a serious clinical problem .',
  'Intestinal ischemia , however , caused , is still a serious and growing clinical problem with an unacceptable mortality rate of over 60 % .',
  'However , the high incidence of tumor metastasis after liver surgery remains a severe problem .',
  'Although liver transplantation offers a chance of cure for patients with advanced liver disease , the shortage and the lack of immediate availability of donors remains a serious problem .',
  'Occlusive diseases of arteries of the lower extremities with underlying atherosclerosis present a serious medical problem .',
  'Disease associated with the vascular system , including peripheral arterial disease , poses a serious health problem with incidence growing annually .',
  'The " territorial belonging " of the middle hepatic vein : a troublesome dilemma in adult live donor liver transplantation -- anatomical evidence based on virtual 3-dimensional-computed tomography-imaging reconstructions .',
  'Ischemia is a troublesome problem that can cause intestinal emergencies and complicate the treatment .',
  'Peripheral arterial occlusive disease ( PAOD ) continues to be a vexing problem despite the advent of endovascular techniques augmenting traditional open repair .',
  'Domino liver transplantation ( DLT ) has been performed for selected recipients at several centers , but de novo amyloidosis in recipients of livers from patients with familial amyloid polyneuropathy ( FAP ) remains a serious concern .',
  'Chronic limb ischemia is a serious clinical problem .',
  'Intestinal edema remains a serious clinical problem , and novel approaches to study its pathophysiology are needed .',
  'Intestinal ischemia and reperfusion ( IR ) syndrome is a life-threatening dilemma caused by diverse events .',
  'Ischemia-reperfusion injury is a serious problem .',
  'Hepatic ischemia-reperfusion injury ( I/R ) is a serious health problem associated with liver transplantation , resection surgery , and various types of shock especially hemorrhagic shock .',
  "Vascular insufficiency of the child 's brain is a serious problem because perfusion can be disturbed sufficiently enough to cause permanent brain changes with extensive neurological deficit resulting in some .",
  'Intestinal ischemia-reperfusion ( I/R ) is a serious clinical dilemma with high morbidity and mortality .',
  'Portopulmonary hypertension ( PPHTN ) is a relatively rare complication of end-stage liver disease , and a serious problem in the context of liver transplantation .',
  'Critical limb ischemia , a severe manifestation of peripheral artery disease , is emerging as a major concern in aging societies worldwide .',
  'Hepatic ischemia reperfusion ( HI/R ) injury may occur during liver transplantation and remains a serious concern in clinical practice .',
  'Hepatic ischemia/reperfusion ( I/R ) injury is a pathologic process caused by hepatic surgery and transplantation , and still remains a severe clinical problem .',
  'Arteriosclerotic diseases are becoming a serious problem all over the world .',
  'The management of ascites is a serious postoperative problem in patients with liver cirrhosis .',
  'Hepatic ischaemia-reperfusion injury is a serious problem that occurs during various surgical operations such as liver transplantation , surgical revascularization , and partial organ resection .',
  'As a complication after surgery for abdominal aortic aneurysms , colonic ischemia remains a serious problem , especially in cases of ruptured AAA .',
  'Chronic mesenteric ischemia is a life-threatening clinical problem resulting in death from inanition and/or bowel infarction , if left untreated , albeit low disease prevalence .',
  'Cerebral ischemia-reperfusion ( IR ) has attracted wide attention as a serious clinical problem .',
  'Ischemia/reperfusion ( I/R ) injury is a serious problem resulting from clinical setting of coronary revascularization .',
  'Ischemia/reperfusion (I/R)-induced oxidative stress is a serious clinical problem in the reperfusion therapy for ischemic diseases .',
  "Cerebral ischemia-reperfusion ( I/R ) injury is also a serious problem for patients ' outcomes .",
  'Confluent hepatic necrosis as well as biliary obstruction were perceived as consequence of a severe perfusion problem in F-M liver transplantation , which was possibly related to an enhancement of ischemia-reperfusion ( I/R ) injury by the lack of estrogen in male recipients of female grafts .',
  'Primary graft dysfunction or nonfunction after liver transplantation , which is usually caused by ischemia/reperfusion injury ( IRI ) , is a serious clinical problem .',
  'In this context , vascular disease represents a serious public health problem , particularly if we take into account current forecasts on population ageing .',
  'However , in Japan , which has a serious problem in the shortage of donor livers , therapies other than transplantation must be further investigated for patients with ALF .',
  'Mesenteric ischemia is a devastating disease process that frequently challenges clinicians .',
  'Liver ischemia/reperfusion injury is a severe problem in transplantation , and preservation solutions could be critical for liver viability .',
  'Ischemia/reperfusion damage to the liver remains a serious concern in many clinical situations .',
  'In liver surgery , postoperative liver failure has been a serious problem of concern .',
  'Peripheral ischemic vascular disease represents a serious problem with high mortality and morbidity .',
  'Reperfusion injury is a serious problem after clinical liver transplantation , often leading to dys- or even non-function of grafts .',
  'Liver regeneration after an extensive liver resection is a serious clinical problem , which is difficult to study in detail on patients .',
  'Ischemic reperfusion ( I/R ) injury is a serious problem in the treatment of ischemic heart disease .',
  'Vascular disease is a serious public health problem in the industrialized world , and is a frequent cause of death among the adult population of Brazil .',
  'Ischemia-reperfusion injury causes oxidative stress producing reactive oxygen species , which is a serious problem linked to morbidity and mortality in liver surgery .',
  'In particularly , hippocampal injury after ischemia-reperfusion is a serious problem as it contributes to vascular dementia .',
  'Ischemia is a serious problem in clinical medicine , and effective methods are needed to detect ischemia before the injury becomes irreversible .',
  'Although dysplasia was a serious diagnostic concern , we concluded that ischemia due to the intestinal atresia induced this benign pseudodysplastic regenerative mucosa , judging from the pattern of coexisting inflammation and the literature review .',
  'Unfortunately , cerebral re-perfusion syndrome is a serious unresolved problem .',
  'Liver transplantation and hepatocyte transplantation are effective treatments for severe liver injuries , but the donor shortage is a serious problem .',
  'Peripheral vascular disease ( PVD ) is a devastating medical problem that may lead to significant life alterations for patients , from simply limiting their daily activities to potential loss of limbs and eventual demise .',
  'Massive blood transfusion related to the coagulation disorders occurring during the anhepatic and reperfusion phases , remains a serious problem during orthotopic liver transplantation .',
  'In many reconstructive surgical procedures involving microsurgery and prolonged tissue ischemia time , IRI-induced skeletal-muscle injury is a serious clinical concern .',
  'Liver failure due to ischemia-reperfusion injury , believed to be closely related to the generation of oxygen-free radicals , is a serious problem during liver surgery .',
  'Ischemia-reperfusion injury ( IRI ) has been recognized as a serious problem for therapy of cardiovascular diseases .',
  'Inflammatory response that occur post-ischemia is a serious problem in the treatment of ischemic brain disease .'],
 'diabetes': ['As exchange counting poses difficulty for children with type 1 diabetes (T1D) attending diabetes camps, they often guesstimate food amount without performing an exchange calculation.',
  'Offspring of women with diabetes in pregnancy are at increased risk of type 2 diabetes mellitus (T2DM), potentially mediated by epigenetic mechanisms.',
  'The prevalence of type 2 diabetes among Malaysian adults has increased by more than two folds over the past two decades',
  'Diabetic kidney disease (DKD) is 1 of the common microvascular complications of diabetes, and the therapeutic effect of modern medicine on DKD is limited',
  '\xa0Diabetes mellitus (DM) is considered to be a significant public health problem globally',
  'Inflammation is recognized as the key pathological mechanism of type 2 diabetes',
  'Diabetic Ketoacidosis (DKA) is one of the most commonly encountered diabetic complication emergencies',
  'A problem with older criteria for diagnosing diabetes was that many individuals classified as having borderline or chemical diabetes reverted to nondiabetic status on follow-up .',
  'Native glucagon-like peptide-1 ( GLP-1 ) , which makes β-cells competent and diabetic β-cells specifically more sensitive to glucose , has a major drawback of rapid inactivation .',
  'This paper reports a flexible electronics-based epidermal biomicrofluidics technique for clinical continuous blood glucose monitoring , overcoming the drawback of the present wearables , unreliable measurements .',
  'A significant drawback of the exogenous administration of insulin to diabetics is the non-physiological profile of insulin action resulting in the insufficient suppression of hepatic glucose production , which is the main contributing factor to diabetic hyperglycemia under fasting conditions and the basis of the challenge to restore a more physiological glucose profile in diabetes .',
  'Type 2 diabetes mellitus is a serious , growing , and costly public health problem .',
  'Diabetic gastropathy : a practical approach to a vexing problem .',
  'Diabetes mellitus is a debilitating health care problem affecting 382 million people around the world and one of the most common complications is diabetic nephropathy .',
  'Diabetes mellitus is a serious health problem in Australia and if nurses are to effectively care for clients with this condition , they need to undertake specialised training in this area .',
  'Diabetes is a serious health problem .',
  'Diabetes is a serious and chronic problem that can be attributed to the insufficient release of the insulin or when body does not respond to the insulin which is already present .',
  'In recent years there has been a rise in the number of diabetic patients in Japan , with the increase in elderly diabetic patients becoming a serious problem .',
  'Diabetes is a serious health problem .',
  'Forensic medicine may face a serious problem when solving the death cause associated with disorders in glucose metabolism , especially in cases when dying due to diabetes mellitus is characterized as unclear natural death .',
  'Diabetes mellitus is a serious health concern that most commonly affects older people .',
  'Diabetes is a serious public health problem in the United States .',
  'The incidence of diabetes is increasing at an unprecedented pace and has become a serious health concern worldwide during the last two decades .',
  'Diabetes mellitus is a serious health problem in the world and about 20 to 40 % of the patients are being affected with diabetic nephropathy .',
  'Type 2 diabetes mellitus ( T2DM ) is a serious global health problem , currently affecting an estimated 451 million people worldwide .',
  'diabetes is a serious health problem and a source of risk for numerous severe complications such as obesity and hypertension .',
  'Type 2 diabetes mellitus ( T2D ) , is a life-threatening condition of global public health concern .',
  'This phenomenon poses a severe problem in the treatment of patients with diabetes mellitus , but the underlying neuroendocrine mechanisms are unclear .',
  'Affecting more than 6 % of the population in the United States , type 2 diabetes and its complications have become a serious public health concern that exerts a substantial toll on the individuals affected , the entire health care system , and the economy , including employers .',
  'This effect is a serious concern for investigators who use NOD mice for diabetes research because the expected incidence of disease decreases markedly when they are colonized by SFB .',
  'Diabetic renal disease is a serious problem resulting from microvascular complications in both type 1 and type 2 diabetes mellitus .',
  'Diabetic renal disease is a serious problem resulting from microvascular complications in both type 1 and type 2 diabetes mellitus .',
  'Hypoglycaemia , however , can be a serious problem if glucose-containing solutions are avoided during the first four hours , as suggested in some studies .',
  'Type 2 diabetes ( T2DM ) among the young population has become a serious concern globally , presumably due to the rising trend of obesity .',
  'Together , aging and diabetes have contributed to dementia becoming a serious problem .',
  'Diabetes has become a serious health problem and a major risk factor associated with troublesome health complications , such as metabolism disorders and liver-kidney dysfunctions .',
  'Diabetes is a debilitating health care problem affecting 422 million people around the world .',
  'While the prevention of acute metabolic decompensation is no longer a serious problem in treating patients with non-insulin-dependent diabetes mellitus ( NIDDM ) , target organ complications can have serious consequences , including blindness , renal failure , neuropathy , amputation , coronary artery disease , and stroke .',
  'Diabetes mellitus is a chronic degenerative disease that causes long-term complications and represents a serious public health problem .',
  'Prevalence of diabetes , a serious public health problem is rapidly increasing worldwide .',
  'Diabetes has emerged as a serious health problem in the Navajo nation , the largest Indigenous tribe in the US .',
  'Diabetes is a serious health concern .',
  'Diabetic kidney disease ( DKD ) is a serious disease that presents a major health problem worldwide .',
  'Type 2 diabetes mellitus represents a serious medical , social and economic problem , since it has become a pandemic in recent years , affecting up to 1/3 of the Czech population in old age .',
  'Type 2 diabetes represents a serious societal health problem due to the vulnerability to cardiovascular events .',
  'Diabetes mellitus is a serious health problem in both dogs and humans .',
  'Thirty-eight per cent saw themselves at increased risk of diabetes and 34 % thought diabetes a serious problem .',
  'Diabetic retinopathy is a serious public health concern .',
  'The incidence of type 2 diabetes mellitus ( DM ) has been increasing rapidly , and the disease has become a serious sociomedical problem .',
  'Type 2 diabetes is a serious problem for developed and developing countries .',
  'Type 2 diabetes is a serious problem for developed countries .',
  'Diabetes mellitus is being increasingly recognized as a serious global health problem and is frequently associated with co-morbid depression .',
  'Diabetes mellitus is a serious health and social problem of modernity , which in the future will increase and experts predict that the number of patients in 2030 will exceed 438,4 million .',
  'Diabetes mellitus ( DM ) is a serious health and social problem .',
  'Glycemic instability is a serious problem in patients with insulin-deficient diabetes , and it may be due in part to abnormal endogenous glucagon secretion .',
  'The diabetes epidemic remains a serious problem in this First Nation community .',
  'Diabetes mellitus has become a serious and growing public health concern .',
  'Diets high in sugar are recognized as a serious health problem , and there is a drive to reduce their consumption .',
  'Diabetes mellitus ( DM ) is a serious public health problem and can cause long-term damage to the brain , resulting in cognitive impairment in these patients .',
  'Youth-onset type 2 diabetes is a serious public health problem for Indigenous people throughout the world .',
  'Diabetes mellitus ( DM ) is a serious medical problem .',
  'Type 2 diabetes is a serious health problem that affects more than 7 % of adults in developed countries .',
  'However , it can increase the chances of muscle damage , a serious problem for diabetic patients .',
  'Inadequate quality of care provided to people with type 2 diabetes mellitus , generates a significant socioeconomic burden and a serious public health problem .',
  'Diabetes mellitus is currently a serious public health problem worldwide , that increases the risk of presenting microvascular and macrovascular complications .',
  'Diabetes mellitus ( DM ) is a serious problem worldwide and is becoming increasingly prevalent .',
  'Because diabetes is a preventable disease , it is of concern that it is occurring in this population of younger and presumably more fit individuals .',
  'Neurological complications of diabetic ketoacidosis are considered to be a serious clinical problem .',
  'Although limited success has been made to control insulin gene expression in ectopic cells using hormone/glucose-regulated expression systems , these transcriptionally regulated systems are relatively slow in the " on- " and " off"-kinetics of insulin production , raising a serious safety concern for clinical application .',
  'Diabetes is a threatening public health concern .',
  'Diabetes mellitus constitutes a serious public health problem .',
  'Diabetes in Mexico -- a serious and growing problem .',
  'Diabetes mellitus ( DM ) is a serious global health problem currently affecting over 450 \xa0 million people worldwide .',
  'Diabetes mellitus ( DM ) is frequently increased in many countries and become a serious health problem worldwide .',
  'Diabetes is a serious public health concern in the UK .',
  'Diabetes mellitus is a serious problem that will soon reach epidemic proportions in the United States and throughout the world .',
  'Diabetes Mellitus ( DM ) is a serious medical problem that causes long-term systemic complications and considerable associated morbidity .',
  'Diabetes is a serious public health problem in the border region between the United States of America and Mexico , reflecting and by some measures surpassing the extent of national diabetes burden of each country .',
  'Gestational Diabetes Mellitus ( GDM ) is a serious health concern for pregnant women , with Hispanic women at particular risk for developing the condition .',
  'The increase in the prevalence of diabetes has become a severe problem around the world ; mainly affecting indigenous communities as the Mayan of Yucatán in Mexico .',
  'Disordered eating is a serious and under-recognized problem in people with diabetes .',
  'Diabetes mellitus is a serious public health concern .',
  'Although labeled a risk factor , clinicians should emphasize that prediabetes remains a serious concern that will not lessen without intervention .',
  'Recurrent diabetic ketoacidosis is a serious and not uncommon health problem .',
  'Neuropathy of the cranial nerves , despite being a rare entity in diabetes mellitus , appears to be a serious problem from a diagnostic and therapeutic point of view .',
  'In the ongoing COVID-19 pandemic situation , diabetes has become a serious health concern since large numbers of patients are vulnerable to die from the virus .',
  'Type 2 diabetes mellitus ( T2DM ) is a severe health problem worldwide , reaching epidemic levels .',
  'In recent decades , Diabetes Mellitus has become a severe and growing global public healthcare problem due to the increase of its prevalence , morbidity and mortality .',
  'Diabetes mellitus is a serious , costly and growing public health problem .',
  'Diabetic nephropathy ( DN ) that progress to end stage renal failure is a serious health problem .',
  "The rising worldwide incidence of diabetes , combined with the lack of reliable endpoints of the body 's true capacity to produce insulin , constitute a serious dilemma facing healthcare professionals and the pharmaceutical industry .",
  'The number of diabetes mellitus and borderline diabetes cases is increasing and poses a serious problem worldwide .',
  'Type 2 diabetes in adolescents : a severe phenotype posing major clinical challenges and public health burden .',
  'Diabetes is a serious disease posing a public health problem in our country , since it affects a great number of productive age persons , causing , if uncontrolled , deleterious effects on their life quality and expectancy because of vascular and neural complications .',
  'Type 2 diabetes mellitus ( T2DM ) is rapidly prevailing as a serious global health problem .',
  'Diabetes in pregnant Mexican-American women is a serious and expensive health problem .',
  'Failure to properly dispose of glucose in response to insulin is a serious health problem , occurring during obesity and is associated with type 2 diabetes development .',
  'Diabetes mellitus is a serious public health problem worldwide and particularly in developing countries .',
  'The high prevalence of diabetic retinopathy observed in all major ethnic groups in Mauritius portends a serious public health problem , given the relative recency of the NIDDM epidemic in that country and the limited resources for laser photocoagulation .',
  '23 Patients aged 21 - 52 with insulin dependent diabetes mellitus ( seven with symptoms suggesting autonomic neuropathy , nine with a serious clinical problem with hypoglycaemia , and seven without symptoms of autonomic neuropathy and without problems with hypoglycaemia ) and 10 controls with a similar age distribution , without a personal or family history of diabetes .',
  "The panel discussion organized as a part of 4th Annual global diabetes convention of Jothydev 's Professional Education Forum ( JPEF , 2016 ) facilitated a platform to address diabetes as a serious health concern that needs to be given immediate priority by the policymakers as well as public and also to discuss about the feasible measures that will help achieve cost effective and affordable diabetes treatment .",
  'Hyperglycemia is a serious health problem prevailing in diabetes patients .',
  'Diabetes , a disease in which the body does not produce or use insulin properly , is a serious global health problem .',
  'With a developing worldwide epidemic of diabetes mellitus , the renal complications associated with diabetes have become a serious health concern .',
  'With regard to the increasing number of diabetics in RDT , moreover associated with their high polymorbidity , this is a serious medical and economic problem .',
  'Within the United States , diabetes is a serious public health concern and patients with diabetes are more likely to experience clinical depression , psychological distress , and depressive symptoms than those without .',
  'Hypoglycemia is a serious problem in insulin-treated diabetic patients .',
  'With worldwide epidemic of diabetes mellitus , diabetic nephropathy which is one of the major causes of microvascular complication has become a serious concern in Korea as well as the rest of the world .',
  'Secondary failure to oral hypoglycemic agents ( OHAs ) is a possible outcome for non-insulin-dependent diabetes mellitus ( NIDDM ) patients and poses a serious therapeutic problem .',
  'The incidence of type 2 diabetes mellitus ( non-insulin-dependent diabetes mellitus ) is growing worldwide and poses a serious public health problem in a current paradigm of changing life style and food habits .',
  'Type 2 diabetes mellitus is a serious public health problem worldwide .',
  'Hypoglycemia is a severe clinical problem with physical and psychosocial implications for people with type 1 and type 2 diabetes .',
  'Diabetes mellitus is a serious and increasing health problem in Australia and is a designated national health priority .',
  'Diabetes is a serious health problem affecting approximately 29.1 million individuals in the United States .',
  'There is a serious gap in the official epidemiological information ; placing the real problem in perspective would help to establish the adequate public policies for both , prevention and investigation of the causes of SD in Mexico .',
  'Nowadays diabetic nephropathy ( DN ) has become a serious problem .',
  'Hypoglycemia is a major barrier to achieving stable metabolic control in patients with diabetes which is a serious clinical concern .',
  'Diabetes mellitus is a chronic metabolic disease which is a serious global problem .',
  'In the United States ( US ) , diabetes mellitus is a serious and costly public health problem , affecting more than 16 million people .',
  'Diabetes is a serious global health problem .',
  'Type 2 diabetes is a serious clinical problem in both India and the UK .',
  'Metabolic disorders associated with diabetic patients are a serious concern .',
  'Diabetes mellitus is a serious and growing health problem worldwide and is associated with severe acute and chronic complications .',
  'Intervention was a previously validated invitation to inform the decision to attend screening , presenting diabetes as a serious potential problem , and providing details of possible costs and benefits of screening and treatment in text and pie charts .',
  'Diabetic angiopathy is a serious problem in antidiabetic therapy .',
  'Diabetes mellitus is becoming a serious public health problem in Sri Lanka and many other developing countries in the region .',
  'Type 2 diabetes is a chronic disease and a serious global public health concern increasing both mortality and morbidity .',
  'Diabetes mellitus , one of the fastest growing epidemics worldwide , has become a serious health problem in modern society .',
  'Diabetes mellitus is a serious health problem affecting the entire population all over the world for many decades .',
  'Diabetes , a serious public health problem , is on the rise , claiming millions of victims .',
  'Type 2 Diabetes Mellitus ( T2DM ) is a serious problem in the world .',
  'Diabetes mellitus ( DM ) due to its increasing prevalence and associated morbidity and mortality has become a serious public health problem .',
  'Type 1 diabetes mellitus is a serious health problem that affects several million new people each year .',
  'The metabolic syndrome and type 2 diabetes can contribute to accelerated atherosclerosis and , therefore , the target organ damages can carry a serious problem for the individuals and also for the whole society .',
  'Diabetes is a serious health problem for pediatrics .',
  'The rise in the incidence of diabetes is a serious public health concern .',
  'Diabetes mellitus is now a serious and increasing problem in Asian countries , where dietary patterns have shifted toward Westernized foods and people are becoming more sedentary .',
  'Hence , diabetes has to be classified as a serious public health concern .',
  'Diabetes represents a serious health problem .',
  'In conclusion , severe hypoglycaemia is a serious and not uncommon problem among elderly patients with T2DM ; it is more frequent in patients undergoing aggressive diabetes management and in users of a long-acting sulphonylurea ( eg , glibenclamide ) .',
  'Diabetes Mellitus ( DM ) is a serious problem in West Virginia .',
  'Type 2 diabetes ( T2D ) is a serious and increasing problem in the UK .',
  'Diabetes mellitus ( DM ) is a considerably diagnosed metabolic disease and a serious problem worldwide .',
  'Peripheral vascular disease is a serious and frequent problem in diabetic patients .',
  'Type 2 diabetes mellitus ( T2DM ) is a serious public health problem , and the phenomenon of T2DM occurring in younger people has directed more attention to functional changes in the brain .',
  'Since diabetes has fast become a serious concern among various demographic groups , this manuscript will also review another educational initiative and make recommendations for implementing successful elements elsewhere .',
  'There is a serious gap in the official epidemiological information ; placing the real problem in perspective would help to establish the adequate public policies for both , prevention and investigation of the causes of SD in Mexico .',
  'Rapid increasing prevalence of diabetes mellitus is a serious health concern in the world .',
  'Diabetes mellitus ( DM ) is a serious public health problem .',
  'Diabetes is a serious , costly , and major health problem worldwide .',
  'Our study suggests diabetes education is a serious concern in China , and a significant proportion of the participants did not receive advice on smoking control and foot care .',
  'Type I diabetes ( T1D ) is a rapidly increasing autoimmune disease especially in the Western countries and poses a serious global health problem .',
  'Oxidative stress has been involved in the aging process and the pathogenesis of type-2 diabetes , which is a serious health problem worldwide .',
  'Diabetes , a metabolic disorder of glucose , is a serious chronic disease and an important public health problem .',
  'In Mexico , diabetes represents a serious public health problem and a high-cost disease for the health system .',
  'The emerging epidemic of type 2 diabetes in the pediatric population , especially among minorities whose proportion in the U.S. population is increasing , presents a serious public health problem .',
  'Type 2 diabetes mellitus ( T2DM ) is a serious public health problem accompanies with several complications .',
  'Ophthalmoplegia , despite being a rare entity in diabetes mellitus , is associated with great anxiety for the patients and often appears to be a serious problem from a diagnostic and therapeutic point of view .',
  'Diabetes mellitus is a serious global health problem , and cardiovascular complications are the major cause of morbidity and mortality in diabetic patients .',
  'Diabetes mellitus is a serious world health problem and one of the most studied diseases ; a major concern about its treatment is that β-cell mass and functionality is hard to restore .',
  'Hyperglycemia is a serious health problem in government employee .',
  'The rising epidemic of type 2 diabetes mellitus & associated complications is a serious cause of concern for humanity .',
  'Type 2 Diabetes Mellitus is a serious health problem . In the year 2030 it will affect 366 million people around the world .',
  'Diabetic mellitus is a serious and growing health problem worldwide .',
  'An impaired awareness of hypoglycemia is a serious problem in diabetic patients , which can lead to life-threatening severe hypoglycemia .',
  'Diabetes is a serious public health problem .',
  'The rising prevalence of diabetes mellitus ( DM ) is a serious global health concern .',
  'Type 2 diabetes mellitus is considered one of the fastest growing diseases in Canada , representing a serious public health concern .',
  'Diabetic nephropathy ( DN ) is a serious complication of diabetes mellitus ( DM ) , which is a major public health problem in the world .',
  'Diabetic kidney disease , a leading cause of end-stage renal disease , has become a serious public health problem worldwide and lacks effective therapies .',
  'Type 2 diabetes is a serious and growing problem in Taiwan where it is the fifth leading cause of death , and health care costs are 4.3 times higher than for people without diabetes .',
  'Diabetes mellitus is a true pandemic ; type 2 diabetes in particular , with its progressive nature , constitutes a serious health problem .',
  'Type 2 diabetes mellitus ( T2DM ) is a chronic , complex and multifactorial metabolic disorder , which has become a serious global health problem .',
  'Diabetes Mellitus ( DM ) is increasingly become a serious global public health concern in developed and developing countries including Ethiopia .',
  'Diabetes is a serious public health problem that is largely managed in primary care .',
  'Diabetes mellitus type 2 ( T2DM ) and its vascular complications are a serious world health problem .',
  'Diabetes is a serious global health problem .',
  'For example , diabetes considerably increases morbidity and mortality linked to cardiovascular pathologies and constitute nowadays a serious public health problem .',
  'Although lower than the prevalence for some other groups of Native Americans , diabetes and its complications represent a serious problem for the Oneida Indians .',
  'Diabetes mellitus is a serious health problem that can lead to several pathological complications in numerous organs and tissues .',
  'Hypoglycemic coma is a serious and not an uncommon problem among elderly patients with diabetes mellitus and treated with insulin and/or oral hypoglycemic drugs .',
  'Diabetes is a devastating and growing problem in the USA and throughout the world .',
  'Diabetic nephropathy ( DN ) has become a serious public health problem .',
  'Treatment of labile ( brittle ) diabetes characterized by variations of the blood sugar level , liability to develop ketoacidosis and in susceptible subjects the development of organ complications , was always a serious problem .',
  'The councils determined that the main barriers to optimal care of community-based patients with NIDDM are that 1 ) NIDDM is not considered or managed as a serious problem by most physicians and their patients ; 2 ) the genetic basis for and refractory nature of obesity are not generally appreciated ; and 3 ) as a complex , multisystemic chronic illness , diabetes fits poorly in a health care delivery system designed to deal with acute and episodic illnesses .',
  'Epidemiological studies show that diabetes mellitus is a serious medical , economic and public health problem .',
  'Diabetes mellitus ( DM ) is a serious and common in the world health problem that leads to different complications .',
  'Diabetes mellitus is a chronic degenerative disease that causes long-term complications and represents a serious public health problem .',
  'Global epidemic of diabetes is a serious health care concern because of its complications and consequently reduced life expectancy and increased morbidity .',
  'Diabetes and its diagnosing during obligatory preemployment or periodic medical examinations constitutes a serious problem .',
  'Type 2 diabetes is a well-known endocrine and metabolic disorder which has reached epidemic proportions worldwide and represents a serious public health concern .',
  'Kidney disease is a serious development in diabetes mellitus and poses an increasing clinical problem .',
  'Type 2 diabetes mellitus ( T2DM ) is a serious health problem with epidemic proportions and associated with high cardiovascular morbidity and mortality .',
  'Non-insulin-dependent diabetes mellitus ( NIDDM ) is a serious health problem among the Zuni Indians of New Mexico .',
  'Thirty-nine subjects ( 38.6 % ) were concerned about diabetes and 85 ( 84.2 % ) considered diabetes a serious problem .',
  'Diabetes mellitus is a chronic disease that is becoming a serious global health problem .',
  'Diabetes mellitus represents a serious public health problem owing to its global prevalence in the last decade .',
  'The growing incidence of diabetes among Hispanics is a serious public health concern .',
  'Type 2 diabetes is a prevalent chronic disease arising as a serious public health problem worldwide .',
  'Diabetes is a serious health problem .',
  'Non-enzymatic glycation , accompanied by the formation of free radicals , represents a serious problem in diabetes mellitus .',
  'The increasing worldwide prevalence of type 2 diabetes mellitus ( T2D ) is a serious global health concern .',
  'Diabetes mellitus is a serious health problem associated with an increased mortality and morbidity .',
  'Despite the progress in diagnosis and treatment of type 1 diabetes , diabetic ketoacidosis ( DKA ) is still a serious clinical problem .',
  'Diabetes mellitus is a serious health and economic problem of our time .',
  'Diabetic kidney disease ( DKD ) , a leading cause of end-stage renal disease ( ESRD ) , has become a serious public health problem worldwide and lacks effective therapies due to its complex pathogenesis .',
  'Diabetes mellitus ( DM ) is recognized as a serious global health problem that is characterized by high blood sugar levels .',
  'In view of the high number of diabetic patients with CHRF which , in addition , associates with their high polymorbidity and extensive demands put on medical and nursing care which is not directly associated with CHRF therapy , we have to do with a serious medical and economic problem .',
  'Diabetes mellitus is a severe health problem in Mexico , and its prevalence is increasing exponentially every year .',
  'Diabetes mellitus ( DM ) is a serious medical problem affecting millions of peoples worldwide , and has a great socio-economic impacts .',
  'Diabetes mellitus is a serious and growing health problem worldwide and is associated with severe acute and chronic complications .',
  "Diabetes is a serious public health problem that threatens the quality of life of patiens with diabetes , the success of long-term maintenance therapy for diabetes depends largely on the patients ' compliance with a therapeutic plan ."],
 'gastrointestinal': ['Chronic intestinal pseudo-obstruction (CIPO) is an intractable rare digestive disease manifesting persistent small bowel distension without any mechanical cause.',
  'Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentation affecting a large amount of older population.',
  'Impairment of gastrointestinal (GI) motility is an undesirable but inevitable consequence of surgery',
  'Eosinophilic gastrointestinal disorders (EGID) are a group of conditions with increased eosinophilic infiltration in any part of the gastrointestinal tract',
  'Bowel obstruction is a serious problem requiring prompt medical intervention to relieve intestinal distention , restore intravascular volume , and correct fluid and electrolyte balance .',
  'Gastrointestinal motility disorders are a serious problem in both veterinary and human medicine and may represent a dysfunction of the neural , muscular or pacemaker components ( interstitial cells of Cajal ) of bowel control .',
  'Gastrointestinal motility disorders often pose a debilitating problem , especially in elderly patients .',
  'Intestinal pseudo-obstruction refractory to medical therapy is a debilitating problem for specialists dealing with gastrointestinal disorders .',
  'Short gut syndrome is a devastating clinical problem with limited long-term treatment options .',
  'Chronic intestinal pseudo-obstruction refractory to medical therapy is a debilitating problem for patients and a challenge for clinicians .',
  'GI intolerance is a common preclinical finding and can be a serious clinical safety concern .'],
 'intestinal': ['Chronic intestinal pseudo-obstruction (CIPO) is an intractable rare digestive disease manifesting persistent small bowel distension without any mechanical cause.',
  'Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentation affecting a large amount of older population.',
  'Impairment of gastrointestinal (GI) motility is an undesirable but inevitable consequence of surgery',
  'Eosinophilic gastrointestinal disorders (EGID) are a group of conditions with increased eosinophilic infiltration in any part of the gastrointestinal tract',
  'Diagnosis and therapy of mesenteric ischaemia as the cause of an acute abdomen is a serious problem because of its 60 - 80 % mortality .',
  'Bowel obstruction is a serious problem requiring prompt medical intervention to relieve intestinal distention , restore intravascular volume , and correct fluid and electrolyte balance .',
  '[ Acute mesenteric ischemia : a severe problem in digestive pathology ] .',
  'Intestinal ischemia-reperfusion injury is a serious and widespread clinical problem .',
  'Injury to the intestinal mucosa is a life-threatening problem in a variety of clinical disorders , including hemorrhagic shock , trauma , burn , pancreatitis , and heat stroke .',
  'Gastrointestinal motility disorders are a serious problem in both veterinary and human medicine and may represent a dysfunction of the neural , muscular or pacemaker components ( interstitial cells of Cajal ) of bowel control .',
  'Gastrointestinal motility disorders often pose a debilitating problem , especially in elderly patients .',
  'Intestinal ischemia-reperfusion ( I/R ) injury is a life-threatening vascular emergency and has long been a disturbing problem for surgeons .',
  'Acute mesenteric ischemia is highly lethal and therefore a serious problem for surgery and intensive care medicine ; accordingly its pathophysiology warrants further study .',
  'Intestinal ischaemia with ensuing gangrene has been a serious clinical problem .',
  'Acute mesenteric ischemia is a serious problem with high morbidity and mortality rates .',
  'Ischemia-reperfusion ( IR ) injury of the small intestine is a serious problem in abdominal aortic aneurysm surgery or small intestine transplantation .',
  'Intestinal ischaemia-reperfusion ( II/R ) injury is a serious clinical problem .',
  'Intestinal ischemia , however , caused , is still a serious and growing clinical problem with an unacceptable mortality rate of over 60 % .',
  'Intestinal pseudo-obstruction refractory to medical therapy is a debilitating problem for specialists dealing with gastrointestinal disorders .',
  'Short gut syndrome is a devastating clinical problem with limited long-term treatment options .',
  'Chronic intestinal pseudo-obstruction refractory to medical therapy is a debilitating problem for patients and a challenge for clinicians .',
  'Ischemia is a troublesome problem that can cause intestinal emergencies and complicate the treatment .',
  'Intestinal edema remains a serious clinical problem , and novel approaches to study its pathophysiology are needed .',
  'Intestinal ischemia and reperfusion ( IR ) syndrome is a life-threatening dilemma caused by diverse events .',
  'Intestinal ischemia-reperfusion ( I/R ) is a serious clinical dilemma with high morbidity and mortality .',
  'GI intolerance is a common preclinical finding and can be a serious clinical safety concern .',
  'As a complication after surgery for abdominal aortic aneurysms , colonic ischemia remains a serious problem , especially in cases of ruptured AAA .',
  'Chronic mesenteric ischemia is a life-threatening clinical problem resulting in death from inanition and/or bowel infarction , if left untreated , albeit low disease prevalence .',
  'Mesenteric ischemia is a devastating disease process that frequently challenges clinicians .',
  'Although dysplasia was a serious diagnostic concern , we concluded that ischemia due to the intestinal atresia induced this benign pseudodysplastic regenerative mucosa , judging from the pattern of coexisting inflammation and the literature review .'],
 'eosinophilic': ['Chronic intestinal pseudo-obstruction (CIPO) is an intractable rare digestive disease manifesting persistent small bowel distension without any mechanical cause.',
  'Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentation affecting a large amount of older population.',
  'Impairment of gastrointestinal (GI) motility is an undesirable but inevitable consequence of surgery',
  'Eosinophilic gastrointestinal disorders (EGID) are a group of conditions with increased eosinophilic infiltration in any part of the gastrointestinal tract',
  'Bowel obstruction is a serious problem requiring prompt medical intervention to relieve intestinal distention , restore intravascular volume , and correct fluid and electrolyte balance .',
  'Gastrointestinal motility disorders are a serious problem in both veterinary and human medicine and may represent a dysfunction of the neural , muscular or pacemaker components ( interstitial cells of Cajal ) of bowel control .',
  'Gastrointestinal motility disorders often pose a debilitating problem , especially in elderly patients .',
  'Intestinal pseudo-obstruction refractory to medical therapy is a debilitating problem for specialists dealing with gastrointestinal disorders .',
  'Short gut syndrome is a devastating clinical problem with limited long-term treatment options .',
  'Chronic intestinal pseudo-obstruction refractory to medical therapy is a debilitating problem for patients and a challenge for clinicians .',
  'GI intolerance is a common preclinical finding and can be a serious clinical safety concern .'],
 'bowel': ['Chronic intestinal pseudo-obstruction (CIPO) is an intractable rare digestive disease manifesting persistent small bowel distension without any mechanical cause.',
  'Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentation affecting a large amount of older population.',
  'Impairment of gastrointestinal (GI) motility is an undesirable but inevitable consequence of surgery',
  'Eosinophilic gastrointestinal disorders (EGID) are a group of conditions with increased eosinophilic infiltration in any part of the gastrointestinal tract',
  'Bowel obstruction is a serious problem requiring prompt medical intervention to relieve intestinal distention , restore intravascular volume , and correct fluid and electrolyte balance .',
  'Gastrointestinal motility disorders are a serious problem in both veterinary and human medicine and may represent a dysfunction of the neural , muscular or pacemaker components ( interstitial cells of Cajal ) of bowel control .',
  'Gastrointestinal motility disorders often pose a debilitating problem , especially in elderly patients .',
  'Intestinal pseudo-obstruction refractory to medical therapy is a debilitating problem for specialists dealing with gastrointestinal disorders .',
  'Short gut syndrome is a devastating clinical problem with limited long-term treatment options .',
  'Chronic intestinal pseudo-obstruction refractory to medical therapy is a debilitating problem for patients and a challenge for clinicians .',
  'GI intolerance is a common preclinical finding and can be a serious clinical safety concern .'],
 'distention': ['Chronic intestinal pseudo-obstruction (CIPO) is an intractable rare digestive disease manifesting persistent small bowel distension without any mechanical cause.',
  'Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentation affecting a large amount of older population.',
  'Impairment of gastrointestinal (GI) motility is an undesirable but inevitable consequence of surgery',
  'Eosinophilic gastrointestinal disorders (EGID) are a group of conditions with increased eosinophilic infiltration in any part of the gastrointestinal tract',
  'Bowel obstruction is a serious problem requiring prompt medical intervention to relieve intestinal distention , restore intravascular volume , and correct fluid and electrolyte balance .',
  'Gastrointestinal motility disorders are a serious problem in both veterinary and human medicine and may represent a dysfunction of the neural , muscular or pacemaker components ( interstitial cells of Cajal ) of bowel control .',
  'Gastrointestinal motility disorders often pose a debilitating problem , especially in elderly patients .',
  'Intestinal pseudo-obstruction refractory to medical therapy is a debilitating problem for specialists dealing with gastrointestinal disorders .',
  'Short gut syndrome is a devastating clinical problem with limited long-term treatment options .',
  'Chronic intestinal pseudo-obstruction refractory to medical therapy is a debilitating problem for patients and a challenge for clinicians .',
  'GI intolerance is a common preclinical finding and can be a serious clinical safety concern .'],
 'hypopigmentation': ['Chronic intestinal pseudo-obstruction (CIPO) is an intractable rare digestive disease manifesting persistent small bowel distension without any mechanical cause.',
  'Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentation affecting a large amount of older population.',
  'Impairment of gastrointestinal (GI) motility is an undesirable but inevitable consequence of surgery',
  'Eosinophilic gastrointestinal disorders (EGID) are a group of conditions with increased eosinophilic infiltration in any part of the gastrointestinal tract',
  'Bowel obstruction is a serious problem requiring prompt medical intervention to relieve intestinal distention , restore intravascular volume , and correct fluid and electrolyte balance .',
  'Gastrointestinal motility disorders are a serious problem in both veterinary and human medicine and may represent a dysfunction of the neural , muscular or pacemaker components ( interstitial cells of Cajal ) of bowel control .',
  'Gastrointestinal motility disorders often pose a debilitating problem , especially in elderly patients .',
  'Intestinal pseudo-obstruction refractory to medical therapy is a debilitating problem for specialists dealing with gastrointestinal disorders .',
  'Short gut syndrome is a devastating clinical problem with limited long-term treatment options .',
  'Chronic intestinal pseudo-obstruction refractory to medical therapy is a debilitating problem for patients and a challenge for clinicians .',
  'GI intolerance is a common preclinical finding and can be a serious clinical safety concern .'],
 'hypomelanosis': ['Chronic intestinal pseudo-obstruction (CIPO) is an intractable rare digestive disease manifesting persistent small bowel distension without any mechanical cause.',
  'Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentation affecting a large amount of older population.',
  'Impairment of gastrointestinal (GI) motility is an undesirable but inevitable consequence of surgery',
  'Eosinophilic gastrointestinal disorders (EGID) are a group of conditions with increased eosinophilic infiltration in any part of the gastrointestinal tract',
  'Bowel obstruction is a serious problem requiring prompt medical intervention to relieve intestinal distention , restore intravascular volume , and correct fluid and electrolyte balance .',
  'Gastrointestinal motility disorders are a serious problem in both veterinary and human medicine and may represent a dysfunction of the neural , muscular or pacemaker components ( interstitial cells of Cajal ) of bowel control .',
  'Gastrointestinal motility disorders often pose a debilitating problem , especially in elderly patients .',
  'Intestinal pseudo-obstruction refractory to medical therapy is a debilitating problem for specialists dealing with gastrointestinal disorders .',
  'Short gut syndrome is a devastating clinical problem with limited long-term treatment options .',
  'Chronic intestinal pseudo-obstruction refractory to medical therapy is a debilitating problem for patients and a challenge for clinicians .',
  'GI intolerance is a common preclinical finding and can be a serious clinical safety concern .'],
 'stress': ['The stress level of undergraduates is increasing at an alarming rate.',
  'The problem with this concept is that many of the current psychoimmunology techniques in use are aimed at alleviating stress effects on the immune system rather than at direct augmentation of immunity by the brain .',
  'A developmentally informed perspective on the relation between stress and psychopathology : when the problem with stress is that there is not enough .',
  'Post-traumatic stress disorder ( PTSD ) is a serious problem not only among workers who experience industrial accidents but also among workers who witness such accidents .',
  'Posttraumatic stress disorder ( PTSD ) is a severe problem among soldiers with combating experience difficult to treat .',
  'Veteran populations are exposed to multiple stressful events , and suicidality among veterans is a serious problem .',
  'Posttraumatic stress disorder ( PTSD ) is a serious mental health concern for returning U.S. military personnel who have a higher prevalence rate of PTSD than the general population .',
  'Mental health issues are a serious concern for many American Indian Veterans , especially for post-traumatic stress disorder and related psychiatric conditions .',
  'Job anxiety is a severe problem in many patients with chronic mental disorders , as it usually results in specific participation problems in the workplace and long-term sick leave .',
  'The findings show that stress is a serious concern for these administrators .',
  'Human stress is a serious health concern , which must be addressed with appropriate actions for a healthy society .',
  'Posttraumatic stress disorder ( PTSD ) is a serious and global problem , a psychiatric disorder that frequently occurs with different comorbidities , and is associated with a high suicide rate .',
  'Post Traumatic Stress Disorder ( PTSD ) can be a debilitating problem in service members who have served in Iraq or Afghanistan .',
  'The effect of psychological stress on health is becoming a serious concern , with figures from the World Health Organization showing that stress-related disorders affect nearly 450 million individuals worldwide .',
  'While post-traumatic stress disorder ( PTSD ) and other trauma- and stress-related disorders ( TSRDs ) represent a serious societal and public health concern , their pathogenesis is largely unknown .',
  'In multivariate analysis , PTSD was positively associated with the perception of stress as a serious problem ( OR \u2009 = \u2009 6.52 ; P-value \u2009 = \u2009 0.003 ) , safety and protection for women in the community ( OR \u2009 = \u2009 2.35 ; P-value \u2009 = \u2009 0.011 ) , care for family ( OR \u2009 = \u2009 2.00 ; P-value \u2009 = \u2009 0.035 ) and Place to live in ( OR \u2009 = \u2009 1.83 ; P-value \u2009 = \u2009 0.04 ) .',
  'Depression is a serious problem among military personnel returning from combat deployments , and is related to a range of adverse outcomes including alcohol and drug abuse , family violence and suicide .',
  'Stress had become a severe problem influencing the mental health development among college students .',
  'Posttraumatic stress disorder ( PTSD ) is a debilitating trauma and stressor-related disorder that has become a major neuropsychiatric problem , leading to substantial disruptions in individual health and societal costs .',
  'Just as traumatic experiences may lead to posttraumatic stress disorder ( PTSD ) in some individuals , grief may also be a serious health concern for individuals who have experienced bereavement .',
  'This could be a serious problem for military or emergency personnel recalled to combat or a disaster site without sufficient time to deal with the effects of their initial experiences .',
  'Post-traumatic stress disorder ( PTSD ) is increasingly becoming recognised as a serious mental health problem ( Department of Health , 1991 ) .',
  'PTSD represents a serious mental health problem after a disaster .',
  'Employee burnout is perceived to be a serious problem in human service organizations serving persons with severe mental illness .',
  'Anxiety-related problems at work are a serious problem in the occupational context , as they come along with sick leave and problems in work participation .',
  'Although PTSD may be a serious problem in some survivors of critical illness , data on the whole population are inconclusive .',
  'Posttraumatic stress disorder ( PTSD ) is a serious health concern .',
  'Stress and inappropriate coping mechanisms constitute a serious problem in police profession .',
  'PTSD is a serious public health concern , which compels the search for novel paradigms and theoretical models to deepen the understanding of the condition and to develop new and improved modes of treatment intervention .',
  'Benzodiazepines and selective serotonin reuptake inhibitors ( SSRIs ) are considered the gold standard for PTSD treatment , but their side effects pose a serious problem .',
  'There is attitude among students of turning a blind eye toward existing stress which is a serious problem and may be harbinger of serious mental and psychosocial problems .',
  'Stress experienced by the urban residents became a serious health problem which requires special attention to be paid to certain subgroups in the population .'],
 'adhesions': ['Postoperative adhesions are the major cause of postoperative complications including intestinal obstruction, infertility, and chronic pelvic pain.',
  'Adhesive small bowel obstruction (ASBO) is one of the most common causes of postoperative morbidity',
  'Postoperative adhesions are the major cause of postoperative complications including intestinal obstruction, infertility, and chronic pelvic pain',
  'Dehiscence of upper gastrointestinal sutures still remains a severe clinical problem and often requires complex surgical repair .',
  'Recurrences after operated adhesive postoperative SBO are a threatening potentiality for patients and a difficult problem facing any surgeon .',
  'Postoperative abdominal adhesion formation is a troublesome clinical problem and a common cause of intestinal obstruction , chronic pain and infertility .',
  'Formation of postoperative intra-abdominal adhesions is a severe problem in surgery .',
  'Anal post-operative pain is one of the principal issues of surgical treatment of hemorrhoids and remains a distressing problem , for patients and physicians .',
  'Formation of postoperative adhesions presents a serious and complex problem in clinical practice .',
  'Despite meticulous techniques by surgeons and the availability of barriers , adhesion formation remains a serious problem , with more than $ 1 billion spent annually on complications arising from adhesions .',
  'Postoperative adhesions are a serious problem .',
  'The development of adhesions after gynecologic surgery is a severe problem with ramifications that go beyond the medical complications patients suffer ( which most often include pain , obstruction and infertility ) , since they also impose a huge financial burden on the health care system and increase the workload of surgeons and all personnel involved in surgical follow-up care .',
  'Intraperitoneal adhesion is a serious problem concerning abdominal surgery .',
  'After abdominal surgery , the formation of postoperative adhesion is a serious problem .',
  'The postimplantation peritoneal adhesions formed with some biomaterials continue to represent a serious problem when these biomaterials are placed in contact with the organs of the abdominal cavity .',
  'Retained surgical gauze is a preventable problem but continues to occur periodically .',
  'Peritoneal adhesion is a serious problem that develops after most abdominopelvic surgeries .',
  'Postoperative intra-abdominal adhesions represent a serious clinical problem .'],
 'postoperative': ['Postoperative adhesions are the major cause of postoperative complications including intestinal obstruction, infertility, and chronic pelvic pain.',
  'Nocebo nausea is a debilitating and prevalent side effect that can develop after conditioning occurs between cues present in the treatment context and the experience of nausea.',
  'Continuous bilateral thoracic paravertebral blockade has been used for analgesia after cardiac surgery, but its efficacy has never been formally tested.',
  'Use of i.v. paracetamol for postoperative pain is well documented, but it is unclear if it can reduce the consumption of opioids during patient-controlled epidural analgesia (PCEA) in labouring parturients.',
  'Adhesive small bowel obstruction (ASBO) is one of the most common causes of postoperative morbidity',
  'Postoperative adhesions are the major cause of postoperative complications including intestinal obstruction, infertility, and chronic pelvic pain',
  'Postoperative nausea and vomiting (PONV) are major complications after general anesthesia',
  'Gastric intolerance manifesting as nausea constitutes a demanding drawback of thiopurines , at times forcing treatment discontinuance .',
  'Dehiscence of upper gastrointestinal sutures still remains a severe clinical problem and often requires complex surgical repair .',
  'Labor epidural failure : a serious concern !',
  'Recurrences after operated adhesive postoperative SBO are a threatening potentiality for patients and a difficult problem facing any surgeon .',
  'Postoperative abdominal adhesion formation is a troublesome clinical problem and a common cause of intestinal obstruction , chronic pain and infertility .',
  'Chronic post-surgical pain ( CPSP ) is a serious problem .',
  'Chronic post-thoracotomy pain ( CPP ) is a vexing clinical problem whose management has received scant attention .',
  'Chronic unexplained nausea and vomiting is a debilitating condition that dramatically decreases patient quality of life and creates diagnostic and treatment challenges for healthcare providers .',
  'Post-operative vomiting , especially in ambulatory surgical patients , remains a troublesome problem .',
  'Postoperative nausea and vomiting ( PONV ) remains a distressing and common problem after strabismus repair in particular in children .',
  'Postoperative nausea and vomiting continues to be a distressing problem despite the availability of new information .',
  'Postoperative nausea and vomiting ( PONV ) after laparoscopic cholecystectomy operations still continue to be a serious problem .',
  'Postoperative pain was a serious problem and thoracic epidural provided satisfactory analgesia .',
  'Formation of postoperative intra-abdominal adhesions is a severe problem in surgery .',
  'Postamputation pain ( PAP ) is a serious problem , and thus far , there is no perfect treatment strategy .',
  'In the context of the much-heralded advantages of laparoscopic surgery , it can be easy to overlook postlaparoscopy pain as a serious problem , yet as many as 80 % of patients will require opioid analgesia .',
  'Postoperative nausea and emesis , especially in ambulatory surgical patients , remains a troublesome problem .',
  'However , several surveys in the last few years demonstrated that postoperative pain in children is still a serious problem , mainly because opioids are avoided .',
  'Anal post-operative pain is one of the principal issues of surgical treatment of hemorrhoids and remains a distressing problem , for patients and physicians .',
  'Nausea and vomiting caused by cytotoxic drugs have been a serious problem in anti-cancer therapy and prompted lots of scientists to find the mechanism and to develop antiemetics .',
  'Chemotherapy-induced nausea and vomiting ( CINV ) continue to be a distressing problem still reported by cancer patients , with negative consequences on quality of life ( QoL ) .',
  'Formation of postoperative adhesions presents a serious and complex problem in clinical practice .',
  'Postoperative nausea and vomiting ( PONV ) remains a troublesome problem .',
  'Postoperative persistent chronic pain ( POCP ) is a serious health problem , disabling , undermining the quality of life of affected patients .',
  'In patients undergoing laparoscopic surgeries , postoperative nausea and vomiting ( PONV ) is a serious concern .',
  'Despite meticulous techniques by surgeons and the availability of barriers , adhesion formation remains a serious problem , with more than $ 1 billion spent annually on complications arising from adhesions .',
  'Pain management after arthroplasties has become a serious problem .',
  'Postoperative nausea and vomiting ( PONV ) is a distressing problem after strabismus surgery .',
  'Such retrospective exaggeration has apparently contributed to the widespread belief that vomiting following gastric bypass surgery is a serious problem .',
  'Post thoracotomy ipsilateral shoulder pain ( PTISP ) is a distressing and highly prevalent problem after thoracic surgery and has not received much attention despite the incidence as high as 85 % .',
  'Nine patients complained of mild memory impairment postoperatively and one had a severe amnestic problem .',
  'Postoperative adhesions are a serious problem .',
  'A distressing problem of persistent postoperative frontal pain is discussed in detail .',
  'The development of adhesions after gynecologic surgery is a severe problem with ramifications that go beyond the medical complications patients suffer ( which most often include pain , obstruction and infertility ) , since they also impose a huge financial burden on the health care system and increase the workload of surgeons and all personnel involved in surgical follow-up care .',
  'Intractable nausea and/or vomiting is a serious and significant clinical dilemma that may greatly detract from quality of life .',
  'Intraperitoneal adhesion is a serious problem concerning abdominal surgery .',
  'After abdominal surgery , the formation of postoperative adhesion is a serious problem .',
  'Postoperative pain still poses a serious problem for 80 % of patients undergoing surgery .',
  'Post-dural puncture headache ( PDPHA ) has been a vexing problem for patients undergoing dural puncture for spinal anaesthesia , as a complication of epidural anaesthesia , and after diagnostic lumbar puncture since Bier reported the first case in 1898 .',
  'Dyspeptic symptoms present a severe problem in gastrointestinal ( GI ) cancer patients .',
  'The postimplantation peritoneal adhesions formed with some biomaterials continue to represent a serious problem when these biomaterials are placed in contact with the organs of the abdominal cavity .',
  'Post-dural puncture headache ( PDPH ) is a vexing problem of the patients following spinal anesthesia or a complication relative to inadvertent dural puncture in epidural anesthesia .',
  'Postoperative nausea and vomiting ( PONV ) is a serious concern in patients undergoing laparoscopic cholecystectomy ( LC ) , with an incidence of 46 to 72 % .',
  'Chemotherapy-induced amenorrhea is a serious concern for women undergoing cancer therapy .',
  'Neurological injuries after epidural/spinal analgesia are a serious but uncommon problem .',
  'Retained surgical gauze is a preventable problem but continues to occur periodically .',
  'Despite the availability of several antiemetics , clinical findings show that control of chemotherapy-induced nausea and vomiting ( CINV ) continues to be a serious concern for hematological patients , mainly for those receiving multiple-day ( MD ) and high-dose ( HD ) chemotherapy ( CT ) .',
  'Post thoracotomy chronic pain is a severe problem that affects the majority of patients and decreases the quality of life .',
  'Chemotherapy-induced nausea and vomiting ( CINV ) is a serious problem for cancer patients receiving chemotherapy .',
  'Intestinal mucositis induced by chemotherapy is a severe clinical problem in cancer patients that currently lack effective interventions .',
  'However , the intense intraoperative pain remains a serious problem .',
  'Postoperative pain is a serious problem , requiring an appropriate response from the medical doctor .',
  'Postoperative persistent chronic pain ( POCP ) is a serious health problem , disabling , undermining the quality of life of affected patients .',
  'Peritoneal adhesion is a serious problem that develops after most abdominopelvic surgeries .',
  'Postoperative intra-abdominal adhesions represent a serious clinical problem .'],
 'adhesion': ['Postoperative adhesions are the major cause of postoperative complications including intestinal obstruction, infertility, and chronic pelvic pain.',
  'Adhesive small bowel obstruction (ASBO) is one of the most common causes of postoperative morbidity',
  'Postoperative adhesions are the major cause of postoperative complications including intestinal obstruction, infertility, and chronic pelvic pain',
  'Dehiscence of upper gastrointestinal sutures still remains a severe clinical problem and often requires complex surgical repair .',
  'Recurrences after operated adhesive postoperative SBO are a threatening potentiality for patients and a difficult problem facing any surgeon .',
  'Postoperative abdominal adhesion formation is a troublesome clinical problem and a common cause of intestinal obstruction , chronic pain and infertility .',
  'Formation of postoperative intra-abdominal adhesions is a severe problem in surgery .',
  'Anal post-operative pain is one of the principal issues of surgical treatment of hemorrhoids and remains a distressing problem , for patients and physicians .',
  'Formation of postoperative adhesions presents a serious and complex problem in clinical practice .',
  'Despite meticulous techniques by surgeons and the availability of barriers , adhesion formation remains a serious problem , with more than $ 1 billion spent annually on complications arising from adhesions .',
  'Postoperative adhesions are a serious problem .',
  'The development of adhesions after gynecologic surgery is a severe problem with ramifications that go beyond the medical complications patients suffer ( which most often include pain , obstruction and infertility ) , since they also impose a huge financial burden on the health care system and increase the workload of surgeons and all personnel involved in surgical follow-up care .',
  'Intraperitoneal adhesion is a serious problem concerning abdominal surgery .',
  'After abdominal surgery , the formation of postoperative adhesion is a serious problem .',
  'The postimplantation peritoneal adhesions formed with some biomaterials continue to represent a serious problem when these biomaterials are placed in contact with the organs of the abdominal cavity .',
  'Retained surgical gauze is a preventable problem but continues to occur periodically .',
  'Peritoneal adhesion is a serious problem that develops after most abdominopelvic surgeries .',
  'Postoperative intra-abdominal adhesions represent a serious clinical problem .'],
 'obesity': ['Three-fourths of adults older than 55 years in the United States are overweight or obese.',
  'Prader-Willi syndrome (PWS) is characterized by excessive adiposity.',
  'Obese patients, mainly females, feel uncomfortable and unsatisfied with their physical appearance; they have a wrong perception of their image and consequently diminish their self-esteem, sometimes showing difficulties in functional areas such as work, relationship, social activity',
  'Due to the high prevalence and adverse consequences, overweight and obesity in children continues to be a major public health concern worldwide',
  'A major drawback of treatment with TZD is body fat gain , but some evidence suggests that the fat is redistributed in a favourable direction , that is , from visceral to subcutaneous depots .',
  'Body fat gain is a major drawback of treatment with adipogenic compounds such as glitazones .',
  "The high prevalence of obesity is a serious public health problem in today 's world .",
  'Obesity is now a serious , emerging problem in developing countries .',
  'Obesity has become a serious worldwide public health problem .',
  'Nowadays , obesity becomes a serious global problem , which can induce a series of diseases such as type 2 diabetes mellitus , cancer , cardiovascular disease , metabolic syndrome , and stoke .',
  'The combination of obesity and type 2 diabetes is a serious health problem , which is projected to afflict 300 million people worldwide by 2020 .',
  'Obesity is a common nutritional disorder , associated with a variety of chronic diseases , among them , type 2 diabetes ( T2DM ) has emerged as a serious worldwide health problem .',
  'An alarming global rise in the prevalence of obesity and its contribution to the development of chronic diseases is a serious health concern .',
  'Obesity is a serious global health problem .',
  'Obesity is a serious and increasing public health problem in the UK .',
  'Based on the analyses presented and on a review of the literature , it is concluded that obesity among women is a serious problem in Latin America and the Caribbean , the Middle East and North Africa , and the CEE/CIS region .',
  'Obesity is a serious health problem in nearly all regions of Europe .',
  'Childhood obesity , which is due in part to lack of physical activity , is a serious concern that requires the attention of the behavioral community .',
  'With the improvement of living standards , obesity has become a serious health problem all over the word .',
  'Childhood obesity is a serious public health problem because of its strong association with adulthood obesity and the related adverse health consequences .',
  'Obesity is a serious public health problem because of the risk factors for diseases and psychological problems .',
  'Severe obesity ( body mass index [ BMI ] ≥40 kg/m(2 ) ) is a serious public health concern .',
  'Childhood obesity is a serious and urgent public health problem .',
  'Obesity is a serious health concern for children and adolescents , particularly in Western societies , where its incidence is now considered to have reached epidemic proportions .',
  'Obesity causes metabolic disease and is a serious health problem around the world .',
  'Diet-related chronic diseases are now a serious global public health problem .',
  'Childhood obesity has become a serious public health problem in many low-and-middle income countries .',
  'despite the fact that childhood obesity is a serious health problem , little is known about its related factors in early childhood .',
  'Obesity is a serious medico-social and economic problem .',
  'Abdominal obesity and diabetes are becoming a serious problem among middle-aged and older adults with normal BMI and abdominal obesity may be related to higher risks of diabetes .',
  'Obesity is a pandemic and a serious global health concern .',
  'The observed dramatic time-related weight gains , most likely due to secular ( period-related ) trends , are a serious public health concern .',
  'The epidemic nature of obesity in industrialized countries is a serious health and social concern .',
  'Obesity will be a serious social problem in Asia-Oceania in the next two decades and we need to prevent the increase of this syndrome .',
  "Childhood obesity is a serious public health concern condition , as excess body fat can negatively affect a child 's health .",
  'However , Republican party affiliation , being female and perceiving obesity as a serious health problem were',
  'Childhood obesity remains a serious problem that requires health literacy projects to engage both parents and children in making healthy choices .',
  'Obesity is a serious worldwide health problem , affecting 20 - 40 % of the population in several countries .',
  'Childhood obesity in rural communities is a serious but understudied problem .',
  'Childhood obesity remains a serious problem in the United States .',
  'Obesity has become a serious health problem .',
  'Obesity is a serious health problem in industrialized countries and is associated with a significant increase in total health care costs .',
  'Obesity is a serious public health problem worldwide and has been associated in epidemiological studies with a unique type of non-atopic asthma , although the causal association of asthma and obesity has certain criteria , such as the strength of association , consistency , specificity , temporality , biological gradient , coherence , analogy and experimentation ; nevertheless , the biological plausibility of this association remains uncertain .',
  'Introduction : Obesity is considered a serious public health problem .',
  'Health providers who try to help these people often feel frustrated , as do the patients , because long-term success is rarely experienced , especially for those patients whose weight is a serious medical problem .',
  'The prevalence of overweight and obesity is increasing worldwide , both in developing and developed countries , and childhood obesity is a serious public health problem .',
  'Obesity has become a serious public health problem all over the world , and prevalence of obesity has increased in cats .',
  'In the 21st century , obesity has become a serious problem because of increasing obese patients and numerous metabolic complications .',
  'Obesity is a serious health problem with a rather difficult treatment and prevention .',
  'Obesity is a multifactorial disease and a serious public health problem .',
  'Obesity has become a severe public health problem worldwide .',
  'Obesity is a serious chronic disease and a public health concern in both developing and developed countries .',
  'Childhood obesity is a serious public health problem today with many potential complications and adverse outcomes for children .',
  'The growing prevalence of childhood obesity has become a serious health problem over the past few decades .',
  'Excess weight and obesity have become a serious problem in adult men of reproductive age throughout the world .',
  'Obesity poses a serious problem to human population as it increases the risk of diabetes , hypertension , metabolic syndrome .',
  'Obesity has become a serious health problem worldwide because it is closely related to the leading causes of morbidity and mortality , including diabetes mellitus , hypertension , atherosclerosis , and dyslipidemia .',
  'Childhood overweight/obesity is a serious public health concern , and primary care has a role to play in tackling it .',
  'Obesity and its comorbidities are considered to be a severe public health problem .',
  'The prevalence of obesity in child population is becoming a serious problem in all advanced countries .',
  'Obesity is a serious health problem and its prevalence has increased over the years .',
  'Obesity is a serious medical problem that disproportionately affects people with severe mental illness .',
  'Here , the trend is still increasing : Overweight and obesity do not only pose a serious health problem in industrialized nations , but increasingly also in developing countries .',
  'Morbid obesity and its rapidly increasing prevalence has became a serious health , social and economic problem not only in Europe , but in other developed countries in the Western world .',
  'Obesity is a severe public health problem worldwide , leading to an insulin-resistant state in liver , adipose , and muscle tissue , representing a risk factor for type 2 diabetes mellitus , cardiovascular diseases , and cancer .',
  'The high prevalence of obesity is a serious public health problem that is expected to affect the already high prevalence of Type 2 diabetes and its complications .',
  'Obesity is a serious health problem and a major risk factor for the onset of several diseases such as heart disease , diabetes , stroke and cancer .',
  'Overweight among 6 - 9-year-old children is a serious public health concern and its variation across the European Region highly depends on the country .',
  'The increasing prevalence of overweight/obesity among children is a serious problem in the Caribbean .',
  'Childhood obesity is a serious public health problem associated with the development of several chronic diseases , such as type 2 diabetes mellitus , dyslipidemia , and hypertension .',
  'The prevalence of obesity in the United States is a serious health concern .',
  'Nowadays , obesity is considered as a serious and growing global health problem .',
  'Accordingly , the regulation of body weight is becoming a serious concern for public health experts and scientists .',
  'Background Overweight in schools is a worrisome public health problem because they increase medium and long term risks of morbidity and mortality especially with an increased risk of persistence of obesity in adulthood .',
  'Obesity , especially early onset of obesity is a serious health concern in both developed and developing countries .',
  'Large-scale research on Pavlovian conditioning and weight control is needed because verification could result in easy and inexpensive mitigation of a serious public health problem .',
  'Obesity is a serious health problem , especially in patients with long-term mental disorders .',
  'Obesity is a serious health problem in adults and children worldwide .',
  'Childhood obesity is a serious problem in the UK , with around 20 % of children aged 10 - 11 being overweight or obese .',
  'Obesity constitutes a severe public health problem due to both its complications as a morbid entity and its association to different chronic diseases .',
  'But in this population , a possible neoplasm underlying weight loss is always a serious concern .',
  'Obesity is a serious health problem , and its prevention is promoted through life style including diet and exercise .',
  'This was correlated with difficulties in glycemic and lipid management , obesity , and vascular complications , implying these clustering to be a serious problem .',
  'Obesity is a health problem in the majority of the developed countries and is emerging as a serious problem in the developing countries .',
  'Obesity and overweight are a serious health problem worldwide with multiple and connected causes .',
  'Obesity , the leading metabolic disease in the world , is a serious health problem in industrialized countries .',
  'Obesity has become a severe public health problem across the world , and seriously affects the health and life quality of human beings .',
  'Childhood obesity is a serious health concern , especially in rural areas .',
  'Obesity is a serious problem that affects children from diverse ethnic backgrounds in both industrialised and developing countries .',
  'Current obesity rates in young children are a serious public health concern ; developing and implementing obesity prevention interventions in childcare settings is a promising avenue to address this issue .',
  'Pediatric obesity is a serious health problem affecting 1 of 6 children in the U.S. A two- to threefold increased incidence is evident in the last two decades .',
  'Obesity is a serious problem in the United States .',
  'Obesity is a serious problem facing patients and healthcare providers around the globe .',
  'In the light of changes in the living conditions of populations , excess adiposity is currently a serious public health problem worldwide .',
  'Rising ROS and systemic inflammation is often a serious concern in many disease conditions including obesity .',
  'Obesity remains a serious health problem for the Greek population ; the alarming rates of excess body weight continue to increase .',
  'Despite educational campaigns , increased awareness , and improved treatment options , the high prevalence of mental illness and comorbid obesity remains a serious problem .',
  'Obesity has become a serious health problem worldwide .',
  'A severe bloat problem occurred in 2 experiments , mild bloat occurred in 2 others , while no visual signs of bloat were observed in the remaining 2 experiments .',
  'Obesity in children is a serious public health problem in Japan .',
  'Linear regression revealed that political affiliation , race , and perceiving obesity as a serious societal problem were significant predictors of legislator support for obesity reduction policies .',
  'Paediatric obesity is a severe public health problem accompanied by several physical and mental complications , mainly due to an imbalance between energy input and output .',
  'Obesity is expected to become a serious social problem in Asia-Oceania in the next two decades , so we need to prevent a corresponding increase of NASH .',
  'When considering whether to use bariatric surgical procedures in a multidisciplinary weight management program for children , the special needs and characteristics of children with a severe weight problem must be considered .',
  'With the exception of patients with a severe psychiatric comorbidity , the concern that obesity surgery will reinforce psychic symptoms and lead to a reduction in the QoL seems to be unfounded .',
  'The increasing frequency of childhood obesity is a serious public health concern .',
  'The growing prevalence of childhood obesity has become a serious health problem over the past decades .',
  'The number of children at risk for overweight and the number of overweight children are increasing and have become a serious public health concern .',
  'Obesity is viewed as a serious public health problem .',
  'Overweight and obesity are now considered as a serious health problem , and a very important risk factor for many diseases .',
  'Obesity is increasing worldwide at an alarming rate . Particularly in Western countries , obesity and related problems have become a serious medical problem and an enormous socio-economic burden .',
  'Childhood overweight has become a serious health problem among children and adolescents in the United States .',
  'Prevention of obesity is no longer a lofty but rather necessary goal that urgently calls for action from governments at all levels , in conjunction with all public and private sector stakeholders , in order to combat a serious and growing public health concern .',
  'Obesity is a serious public health problem within the United States .',
  'Obesity is a chronic disease of multifactorial origin and currently is a serious public health problem .',
  'Significant dropout rates remain a serious concern in pediatric weight control program , but few studies have identified predictors of dropout .',
  'Excess of weight is a serious public health concern in almost all countries , afflicting people of different ages and socioeconomic backgrounds .',
  'Obesity is a serious and increasing health problem worldwide , and the inhibition of adipogenesis is considered to be a potential therapeutic target for it .',
  'The increasing prevalence of childhood obesity constitutes a serious public health problem in both developed and developing countries .',
  'Obesity has become a serious public health problem and a major risk factor for the development of illnesses , such as insulin resistance and hypertension .',
  'The speeding increase and the high prevalence of childhood obesity is a serious problem for Public Health .',
  'Obesity is a serious health problem for all age groups and it also promotes Type 2 diabetes , cardiovascular diseases , cancer and hypertension .',
  'The current study indicates that obesity may emerge as a serious public health problem with which tobacco use may interact .',
  'Obesity is a serious health problem in developed countries .',
  'Obesity has become a serious problem in public health worldwide , causing numerous metabolic diseases .',
  'Obesity is a serious health problem worldwide since it is a major risk factor for chronic diseases such as type II diabetes .',
  'Obesity is a serious health problem worldwide and many genes have been implicated in determination of obesity , but our knowledge of the genes responsible for individual differences in weight loss after physical intervention are poor .',
  'Obesity is recognized as a serious problem in the industrialized and developed countries of the world .',
  'Morbid obesity , with its accompanying human and monetary costs , is a serious and growing health problem worldwide .',
  'The current study indicates that obesity and underweight in combination with smoking may emerge as a serious public health problem .',
  'Obesity , along with its related complications , is a serious health problem worldwide .',
  'Childhood obesity is a global epidemic that is related to environmental and genetic factors and has adverse consequences throughout life , being obese is a serious health problem in childhood and increases the risk of many co-morbidities .',
  'The rapid increase in childhood obesity is a serious public health problem , and has led to the development of many interventions .',
  'Obesity is a serious public health problem and being multifactorial is difficult to tackle .',
  'Obesity is a multifactorial chronic disorder which comprises a serious health problem nowadays .',
  'Obesity has become a serious public health problem worldwide , and dietary composition can play a role in its prevention and treatment .',
  'Obesity has currently become a serious social problem to be solved .',
  'Obesity is more and more considered a serious medical problem associated with hyperlipoproteinemia , diabetes , cardiovascular disease , locomotor system diseases not only in the workers with hypertension and increased body fat , but also in the workers with lumbar syndrome .',
  'Childhood obesity continues to be a serious public health problem across the globe .',
  'The overwhelming increase in the global incidence of obesity and its associated complications such as insulin resistance , atherosclerosis , pulmonary disease , and degenerative disorders including dementia constitutes a serious public health problem .',
  'Obesity is a serious epidemic health problem that can cause many other diseases including type 2 diabetes and cardiovascular diseases .',
  'Concerned Internalisers ( 27 % of the sample ) judged that obesity was a serious health problem , that Australia had among the highest levels of obesity in the world and that prevalence was rapidly increasing .',
  'Obesity is a serious health problem among women across the life span .',
  'Obesity is a serious health problem worldwide , particularly in developed countries .',
  'The global prevalence of obesity poses such a serious concern that the World Health Organization ( WHO ) has described it as a " global epidemic . " Recent literature suggests that the genesis of the problem occurs in the first years of life as feeding patterns , dietary habits , and parental feeding practices are established .',
  'Obesity is a serious health problem all over the world , and inhibition of adipogenesis constitutes one of the therapeutic strategies for its treatment .',
  'Obesity is a serious public health problem that is growing alarmingly worldwide .',
  'Overweight and obesity in many countries have developed into a serious health problem by themselves and by their impact on other pathologies such as insulin resistance , type 2 diabetes , hypertension , heart disease and cancer .',
  'Obesity is a serious global health problem .',
  'Obesity is a severe problem in Blacks , particularly in women .',
  'Although obesity is a serious public health problem , there are few reliable measures of its health hazards in the United States .',
  'Globally , human obesity has become a serious problem leading to the emergence of multiple lifethreatening diseases .',
  'This high prevalence of overweight is a serious concern for public health in Jordan .',
  'Obesity is a serious problem that has been linked with CVD and diabetes via a variety of adipokines .',
  'Recently , adipocytes have been studied with increasing intensity owing to the increased prevalence of metabolic diseases posing a serious public health concern and because metabolic dysfunction can directly induce tumorigenesis .',
  'Many studies have shown that obesity is a serious health problem for our society .',
  'Obesity , just like smoking , is one of the major risk factors for oral disease and is a serious social problem that has reached epidemic proportions in many developed countries .',
  'Childhood obesity due to the consumption of excess calories is a severe problem in developed countries .',
  'Obesity is a serious health problem that is implicated in many metabolic disorders .',
  'Although obesity is considered a severe problem , very little is known about the molecular mechanisms causing the associated degeneration of organs and finally death .',
  'Obesity is the nutritional disorder which has shown the greatest increase in prevalence , even in those countries in which deficiency diseases represent a severe public health problem .',
  'Although obesity is increasingly recognized as a serious health problem , there are still many unanswered questions about how the multiple disorders associated with excess weight gain interact to cause cardiovascular and renal disease .',
  'Obesity has recently risen and become a serious health concern in Korea according to the westernized diet and altered lifestyle .',
  'Obesity is fast becoming a serious health problem worldwide .',
  'Obesity is a serious and rapidly growing health problem worldwide .',
  'Obesity is a serious medical problem worldwide .',
  'The excessive use of health care services by obese people constitutes a serious financial burden to all highly developed countries . As yet however , this has not been recognised to be a problem in Poland .',
  'Parents across the socio-demographic spectrum recognized obesity as a serious problem .',
  "Obesity is still a serious health problem and has a relevant impact on the development of a child 's musculoskeletal system .",
  'Obesity is a serious health problem that increased risk for many complications , including diabetes and cardiovascular disease .',
  'Excessive weight in childhood is a serious public health concern because of its costly health consequences and its increasing prevalence .',
  'Obesity is a serious health problem worldwide .',
  'In recent years , in developed countries and around the world , lifestyle-related diseases have become a serious problem .',
  'Obesity is linked with an increased risk of lymphedema , which is a serious clinical problem .',
  'Dietitians must be key participants in the effort to raise awareness of obesity as a serious health concern for older persons .',
  'Obesity is a serious health problem implicated in many metabolic disorders ( i.e. , hypertension , dyslipidemia , and cardiovascular disease ) .',
  'Early childhood obesity is a serious health problem not only because it causes serious health problems in children , but also because it poses a risk of obesity in the later stages of life .',
  'Obesity is a serious childhood health problem today .',
  'Obesity is becoming a serious problem , especially in industrialized societies .',
  'Overweight and obesity in children are a serious problem .',
  'Obesity remains a serious health problem for the Croatian population ; the alarming rates of excess body weight continue to increase .',
  'Weight gain is a serious health concern .',
  'Overweight/obesity is a serious public health problem in Indonesia with a continuing increase in its prevalence .',
  'Elevated means for BMI and WHR indicated that obesity ( BMI ≥30.0 ) was a serious public health problem in these three kampungs , affecting about 5 % of males and 14 % of females .',
  'Obesity is a severe health problem in Europe and in the USA .',
  'Obesity is a serious international health problem that increases the risk of several common diseases .',
  'Obesity in children and adolescents is a severe health , psychosocial , and economic problem .',
  'Obesity is a serious health problem with an increased risk of several common diseases including diabetes , cardiovascular disease , and cancer .',
  'Obesity is a serious health concern and is associated with a reduced quality of life and a number of chronic diseases , including diabetes , heart disease , stroke , and cancer .',
  'Obesity in the pediatric population is a severe public health problem and is associated with various comorbidities .',
  'Obesity in Poland like in other industrial countries is a serious problem .',
  'Obesity is a serious concern from a personal and public health perspective .',
  'Over the last few years , obesity has been constantly increasing , thus turning it into a serious public health problem , with the subsequent impact on health-related expenditure , particularly in developed countries .',
  'Obesity is a serious , worldwide and growing problem , with associated complications ranging from cardiovascular disease to cancer .',
  'The high prevalence of obesity and overweight is a serious health problem demanding preventive measures in order to avoid complications in later life .',
  'Obesity is a serious health problem and critically related to poor prognosis in cancer , presumably through induction of chronic inflammation .',
  'While child and adolescent obesity is a serious public health concern , few studies have utilized parameters based on the causal inference literature to examine the potential impacts of early intervention .',
  'Obesity is globally a serious public health concern and is associated with a high risk of cardiovascular disease ( CVD ) and various types of cancers .',
  'Obesity is a serious problem of public health and affects all socio-economic groups , irrespective of age , sex or ethnicity .',
  'Overweight is a serious health problem in children and adolescents .',
  'Binge eating among the overweight population : a serious and prevalent problem .',
  'This study has shown that obesity and its primary co-morbidities are emerging as a serious health problem among the study population , with class I obesity being the most common pattern and hypertension being the most common primary co-morbidity .',
  'Obesity is a serious and growing health concern worldwide .',
  'While the significance of obesity as a serious health problem is well recognized , little is known about whether and how biometerological factors and biorhythms causally contribute to obesity .',
  'Obesity has become a serious problem in the United States .',
  'Our data emphasized that obesity constitutes a serious problem among young Thai men .',
  'Obesity has become a serious public health problem .',
  'Age-related decreases in lean mass represent a serious health problem .',
  'The current pace of growth in body weight and complications in children and patients of the young age is a serious problem .',
  'Children obesity is considered a serious public health problem around the world .',
  'Complications of obesity represent a serious socioeconomic problem .',
  'Obesity has become a serious public health problem that has stimulated primordial and primary prevention efforts , and a triad of management options ( lifestyle , pharmacotherapy , and surgical interventions ) .',
  'Obesity constitutes a serious global health concern reaching pandemic prevalence rates .',
  'Obesity is a serious and highly prevalent health problem .',
  'Child obesity is becoming a serious public health concern , and major research effort is being devoted both to understand its aetiology and to improve the effectiveness of prevention strategies .',
  'Obesity is a serious , but unrecognized problem in long-term care .',
  'The prevalence of overweight and obesity was found to be high in the study population and is a serious public health problem .',
  'Obesity is a serious problem , which is now a worldwide health problem .',
  'Childhood obesity has become a severe health problem , especially during the last few decades .',
  'Obesity is a serious health problem that leads to low quality of life and early mortality .',
  'Obesity , a serious public health problem , occurs mainly when food consumption exceeds energy expenditure .',
  'Obesity in the elderly is thus a serious concern and comprehension of the key mechanisms of ageing and age-related diseases has become a necessary matter .',
  'Obesity was a serious problem among women in Turkey .',
  'Obesity in the United States is a serious and preventable health concern .',
  'Obesity is a serious global health problem that is directly related to various morbidities manifestation .',
  'Obesity prevalence has increased the past decades and has become a serious public health problem .',
  'Obesity is a prevalent condition and a serious health concern .',
  'Adipocytes have been studied with increasing intensity as a result of the emergence of obesity as a serious public health problem and the realization that adipose tissue serves as an integrator of various physiological pathways .',
  'Obesity is a serious health problem worldwide associated with an increased risk of life-threatening diseases such as type 2 diabetes , atherosclerosis , and certain types of cancer .',
  'Obesity has become a serious public health problem and a major risk factor for the development of illnesses , such as insulin resistance and hypertension .',
  'Overweight and obesity are considered a serious health problem .',
  'Obesity is a serious problem in our century .',
  'Obesity is a serious health problem in the United States today , and surgical treatment is recognized as long-term effective therapy .',
  'Obesity , widely recognized as a serious health concern , is characterized by profoundly altered metabolism .',
  'Obesity is a serious public health problem having a direct impact on physical and psychological health of individuals .',
  'Binge eating in simple obesity has recently been recognized as a serious clinical problem .',
  'Obesity is a serious public health problem that has important social , economic and health consequences .',
  'Colitis is a serious health problem , and chronic obesity is associated with the progression of colitis .',
  'Overweight and obesity is a serious problem worldwide related to cardiovascular and other diseases .',
  'Obesity constitutes a serious health problem .',
  'Obesity has become a severe public health problem worldwide .',
  'Obesity has become a severe health problem in the Western world , and is rapidly becoming the most common disease of the 21st century .',
  'Sarcopenic obesity ( SO ) is a serious public health concern , few studies have examined the clinical implications of SO in newly-diagnosed type 2 diabetes mellitus ( T2DM ) patients .',
  'The increasing prevalence of childhood obesity is a serious public health problem associated with co-morbidities in adulthood , as well as childhood .',
  'Growing evidence support that insulin resistance may occur as a severe problem due to chronic energetic overfeeding and subsequent obesity .',
  'Obesity , the leading metabolic disease in the world , is a serious health problem in industrialized countries .',
  'Morbid obesity has grown enormously in recent decades , representing a serious public health problem .',
  'The prevalence of obesity in the pediatric population has increased in the last 2 decades and represents a serious health concern , with potential impact on outcomes of hematopoietic cell transplantation ( HCT ) .',
  'The increasing rate of child obesity has developed into a serious concern in contemporary society .',
  'Obesity is a severe public health problem worldwide .',
  'Obesity is a serious health problem in the US and is associated with increased risks of various human diseases .',
  'Obesity is sure to be a serious social problem in Asia-Oceania in the next two decades and we need to prevent the increase of nonalcoholic steatohepatitis .',
  'Childhood obesity has grown very fast over recent decades and now it represents a serious public health problem .',
  'Obesity ( defined as body mass index ( BMI ) higher than 30 ) , is a serious and global public health problem , associated with increased morbidity and mortality and it represents a risk factor for developing various somatic and psychiatric disorders .',
  'Obese subjects often have hypertension and related cardiovascular and renal diseases , and this has become a serious worldwide health problem .',
  'Overweight or obesity has become a serious public health problem in the world , scientists are concentrating their efforts on exploring novel ways to treat obesity .',
  'Overweight/obesity is a serious public health problem that affects a large part of the world population across all age and racial/ethnic groups .',
  'Morbid obesity is a serious health problem associated with disease and mortality .',
  'Obesity is considered a serious public health problem , as an epidemic disease with major global repercussions that is associated with the development of other chronic conditions such as hypertension , diabetes , and cardiovascular diseases .',
  'Obesity is a serious health problem that affects a wide range of patients and disease processes .',
  'Obesity is a serious and very common health problem .',
  'Overweight and obesity seems to be a serious health problem , affecting more prominently people in the lower SES .',
  'The prevalence of childhood obesity has increased worldwide , which is a serious concern as obesity is associated with many negative immediate and long-term health consequences .',
  'Obesity is a severe health problem in children , afflicting several organ systems including bone .',
  'Severe obesity in children and adolescents is now a serious global health concern .',
  'Lifestyle interventions should include advice regarding sleep improvement with promotion of other healthy lifestyle behaviors to tackle childhood obesity , a serious global public health problem .',
  'Due to numerous co-morbidities , obesity represents a serious health and socioeconomic problem worldwide .',
  'Obesity shows a multifactorial disease and presents a serious public health problem , with an alarming epidemic character .',
  'Obesity is a serious public health problem throughout the world , affecting both developed societies and developing countries .',
  'Obesity resulting from interactions of genetic and environmental factors becomes a serious public health problem worldwide with alterations of the metabolic phenotypes in multiple biological matrices involving multiple metabolic pathways .',
  'Obesity among children has emerged as a serious public health problem .',
  'Since obesity is a serious problem as a civilization-related disease , it is very important to investigate genes suspected to be connected with it .',
  'Obesity is a serious health problem in the Western societies , therefore its treatment has become the subject of intense interest in the scientific community .',
  'Obesity is a serious public health problem , especially in some minority communities , and it has been associated with an increased risk of cardiovascular diseases .',
  'Obesity is a serious problem for modern medicine .',
  'Childhood obesity is a serious public health problem resulting from energy imbalance ( when the intake of energy is greater than the amount of energy expended through physical activity ) .',
  'Morbid obesity has become a serious health problem .',
  'Childhood obesity is a serious public health problem and its prevalence is increasing worldwide .',
  'Of interest , the vast number of studies demonstrates the role of microbiota in obesity , a serious public health problem that has reached epidemic proportions in many developed and middle-income countries .',
  'Obesity and metabolic disorders related to it have become a serious problem in Asia .',
  'Obesity is a serious public health problem , and the increasing prevalence of overweight status in the population is a major concern worldwide .',
  'Obesity is a serious problem for both the individual and society due to its health and economic consequences .',
  'Childhood obesity is a serious public health concern worldwide .',
  'Obesity is a serious health problem , and is becoming increasingly common in affluent societies .',
  'Obesity , resulting from excess white adipose tissue , has increased dramatically in recent years resulting in a serious public health problem .',
  'We conclude that , even when accounting for cardiovascular risk factors , being overweight is a serious health problem for older people , especially for those with long-standing weight problems .',
  'the childhood obesity is a serious public health problem because if weight gain continues , complications such as insulin resistance , dyslipidemia , orthopedic disorders , sleep apnea , and metabolic syndrome may occur in other stages of child development .',
  'Weight loss among older patients is a severe problem , associated with an increased incidence of infections , decubiti , and death .',
  'Obesity is a serious health problem that leads to serious physical and psychological problems .',
  'Excess body weight among Quilombola women represents a serious health problem .',
  'Obesity is a serious concern worldwide , for which the restaurant industry holds partial responsibility .',
  'The results show that overweight and obesity are a serious public health problem and confirm the importance of breakfast to prevent overweight .',
  'This procedure is more popular in the Far East countries where obesity is not a serious public health problem .',
  'Adipocyte biology has been intensely researched in recent years due to the emergence of obesity as a serious global health concern and because of the realization that adipose tissue is more than simply a cell type that stores and releases lipids .',
  'Obesity T2DM has become a serious problem in Japan as in Western countries , with over-eating and physical inactivity .',
  'Excessive body fat accumulation can result in obesity , which is a serious health concern .',
  'Obesity is a serious health problem with strong genetic determination .',
  'Obesity is a serious public health problem associated with increased morbidity and mortality .',
  'Obesity has become a severe worldwide problem .',
  'Obesity-associated hypertension is a serious public health concern .',
  'The prevalence of obesity and associated metabolic disorders , including diabetes and cardiovascular disease , is rapidly becoming a severe global health problem .',
  'Obesity is a serious concern because it has been the leading causes of death worldwide , including diabetes , stroke , heart disease and cancer .',
  'Childhood obesity is a serious health concern affecting over 155 million children in developed countries worldwide .',
  'All the media coverage conveyed our intended message that food insecurity is a serious population health problem , confirming that message framing , personal narratives and visual imagery are important in persuading media outlets to carry stories about poverty as a determinant of population health .',
  'Increasing prevalence of overweight and obesity is a serious social and health problem both in the economically developed and developing countries .',
  'Obesity is a serious and growing world healthy problem affecting developed and developing countries .',
  'Rising obesity represents a serious , global problem .',
  'This lifestyle change has emerged as a serious health problem favouring the early development of cardiovascular diseases , insulin resistance or type 2 diabetes mellitus .',
  'Obesity is a serious health problem associated with the pathogenesis of various metabolic diseases .',
  'On the other hand , excessive fat accumulation in humans has become a serious health problem due to worldwide spread of obesity .',
  'Obesity among children is epidemic in the U.S. Although a serious problem because of the rising incidence of Type II diabetes as well as heart disease , it is preventable .',
  'However , obesity remains a serious growing concern .',
  'Obesity is a serious health problem that increases the risk of many complications , including diabetes and cardiovascular disease .',
  'Worsening trends in obesity and T2DM raise a serious conundrum , namely , how to control blood glucose , blood pressure , and lipids when many antidiabetic agents cause weight gain and thereby exacerbate other cardiovascular risk factors associated with T2DM .',
  "An alarmingly high prevalence of childhood obesity among Kuwaiti children , coupled with mothers distorted perception of their child 's actual weight status is a serious concern that requires urgent public health intervention .",
  'Childhood obesity is a serious concern associated with ill health later in life .',
  'Obesity is nowadays a serious worldwide public health problem .',
  'Obesity is a serious global health problem , perhaps the biggest public health issue of our times .',
  'Obesity is proving to be a serious health concern in the developed world as well as an unwanted component of growth in livestock production .',
  'Obesity is a disease that has become a serious public health issue worldwide , and chronic stressors , which are a problem for modern society , cause neuroendocrine changes with alterations in food intake .',
  'Overweight is a worrisome problem .',
  'Recent increases in the number of obese individuals and individuals suffering from lifestyle-related diseases , such as type 2 diabetes , that accompany obesity have become a serious social problem .',
  'Obesity among Pasifika people living in New Zealand is a serious health problem with prevalence rates more than twice those of the general population ( 67 % vs 33 % , respectively ) .',
  'Morbid obesity is a serious health problem whose prevalence is increasing .',
  'Obesity is a serious public health problem because its association with the risk to develop various chronic diseases .',
  'Childhood obesity remains a serious concern in the United States and in many other countries .',
  'Obesity is a severe health problem worldwide , which leads to multiple comorbidities including type 2 diabetes mellitus and cardiovascular diseases .',
  'Obesity is a major risk factor for the development of illnesses , such as insulin resistance and hypertension , and has become a serious public health problem .',
  'Obesity means a serious medical , public health and economic problem , and it requires higher public awareness and political support . Orv . Hetil . , 2016 , 157(31 ) , 1248 - 1255 .',
  'Obesity is a serious and growing public health problem in the United States and the world .',
  'Obesity represents a serious health problem as it is rapidly increasing worldwide .',
  'In recent decades , obesity has become a serious public health problem affecting both children and adults .',
  'We thus propose that neurodegeneration is a possible cause of human obesity and related metabolic diseases , which have become a serious public health problem worldwide .',
  'Obesity is common enough to constitute a serious medical and public health problem .',
  'The lack of awareness about the potential impact of obesity on health and optimal treatment options is a serious concern , which needs to be addressed by appropriate public health programs at national level .',
  'She ate large amounts of food and her overweight became a serious problem in her care at home .',
  'Increasing obesity is a serious public health as well as economic problem .',
  'Obesity is a serious health problem in the United States .',
  'This number translates a serious public health problem , since it also increases the risk of several other diseases associated with obesity resulting in significant morbidity and mortality .',
  'Obesity is a global epidemic that poses a serious health concern due to it being a risk factor for life-threatening chronic diseases , such as type 2 diabetes , cancer , and cardiovascular diseases .',
  'Obesity , a serious public health problem , relates to a chronic low-grade systemic inflammation and is involved in the development of obesity-linked disorders including insulin resistance , type 2 diabetes , cardiovascular diseases , dyslipidemia , and metabolic syndrome .',
  'Overweight in children is a serious public health problem .',
  'Obesity in children is a serious public health problem , and TV viewing is considered a potential risk factor .',
  'Our findings showed a relatively high prevalence of overweight and obesity in Tehranian preschool children that is a serious problem .',
  'Obesity in childhood represents a serious health problem , as an obese child frequently remains obese subject in adulthood .',
  'These additional expenditures pose a serious current and future problem , given the potential for higher obesity prevalence in the coming decade .',
  'Obesity is a serious international health problem that increases the risk of several diet-related chronic diseases .',
  'With 80 % of its population overweight , 47.5 % obese , and having the eighth fattest population worldwide , Kuwait has a serious obesity problem .',
  'Childhood obesity is a serious public health problem , demanding urgent and clear defined actions in order to stop the rapid increase on its prevalence and all health consequences associated .',
  'Obesity is a serious social problem , one of the most important health issues of the modern world , especially in industrialized countries .',
  'The survey findings suggest the majority of the Australian population recognises obesity to be a serious health problem , and support government regulation of the food environment as a population-level preventative strategy .',
  'As obesity is a serious health problem which promotes metabolic abnormalities ( insulin resistance , hyperinsulinemia and dyslipidemia ) and dramatically increases the risk for CVD , this review will focus on the epidemiologic and genetic background of obesity .',
  'Less than 10 % of obese adults accept that they have a serious weight problem , survey finds .',
  'Childhood obesity has become a serious public health problem .',
  'Childhood obesity is a serious public health concern internationally , and population-level interventions are needed to support healthy food choices .',
  'The increase in childhood obesity is a serious public health concern .',
  'Morbid obesity is a serious health problem associated to a significant reduction in life expectancy .',
  'Overweight and obesity have become a serious health problem globally due to its significant role in increased morbidity and mortality .',
  'Obesity is a serious health problem because of its co-morbidities .',
  'Even though there is a severe obesity problem in Cyprus , information about the contribution of predisposing lifestyle factors is limited .',
  'The results confirm that overweight and obesity are a serious public health problem in Portuguese children and adolescents , and urgent measures are needed to suppress this epidemic and reverse the situation as soon as possible .',
  'The scientific , medical , and lay communities are currently confronted with a serious medical and public health problem related to the marked non-remitting worldwide epidemic of obesity .',
  'Obesity is a chronic disease and a serious health problem that leads to increased prevalence of diabetes , hypertension , dyslipidemia and gallbladder disease .',
  'Obesity causes metabolic disease and is a serious health problem around the world .',
  'The prevalence of obesity has been increasing sharply and has become a serious public health problem worldwide .',
  'The childhood obesity epidemic continues to be a serious concern in the U.S. , disproportionately affecting low socioeconomic and minority groups .',
  'Childhood obesity is a serious public health concern , and although the complexity of this issue is now recognized , programming has yet to consider the interconnected nature of the contributing factors .',
  'Obesity is a serious public health concern in the Gulf States .',
  'Obesity is a serious health problem throughout the world .',
  'Obesity is becoming a serious problem in disabled individuals .',
  'Obesity has become a severe health problem in the world .',
  'Obesity is a serious health problem , while the current anti-obesity drugs are not very effective .',
  'The association between being overweight/obese and deprivation is a serious concern in English schoolchildren .',
  'Obesity is a serious medical problem worldwide and disruption of metabolic/energy homeostasis plays a pivotal role in this global epidemic .',
  'Overweight and obesity are considered a serious health problem in Thailand .',
  'Obesity is a serious and growing public health problem in the United States and the world .',
  'Obesity is a serious public health problem associated with predisposition to develop metabolic diseases .',
  'Obesity has become a serious social problem in industrialized countries in recent years .',
  'Childhood obesity is becoming a serious problem , and prevention programs are needed .',
  'Although it is not generally a life-threatening disease , obesity is becoming a major health problem worldwide .',
  'Childhood obesity is a serious health problem worldwide with a prevalence rising to epidemic proportions .',
  'Childhood obesity has reached epidemic levels and is a serious health concern associated with metabolic syndrome , nonalcoholic fatty liver disease , and gut microbiota alterations .',
  'Obesity is a serious health problem worldwide associated with an increased risk of life-threatening diseases such as type 2 diabetes , atherosclerosis , and certain types of cancer .',
  'An increasing epidemic of obesity has become a serious public health concern primarily because it contributes to pathogenesis of many chronic diseases including type 2 diabetes , cardiovascular disease , hepatobiliary disease , obstructive sleep apnea , kidney disease , some types of cancer , among others .',
  'Thus , the understanding of excessive body weight as a serious health and social problem sets one of the priorities in the area of public health .',
  'Obesity remains a serious public health problem .',
  'There is a severe obesity problem in the Cypriot population ; almost one in two adults and at least one in four preadolescent children are overweight or obese .',
  'Obesity is a severe medical problem endangering the health of individuals worldwide .',
  'Fat accumulation with aging is a serious problem ; glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide ( GIP ) is an incretin that plays an important role in fat accumulation .',
  'In particular , obesity is a serious problem that increases the risk of cardiomyopathy and affects nursing care .',
  'Excess fat accumulation continues to be a serious problem for the chicken industry .',
  'Childhood obesity is a serious public health problem and epidemiological studies are important to identify predictive factors .',
  'Obesity rates in the geriatric population have emerged as a serious health concern in recent decades .',
  'Our findings supported the hypothesized model : perceptions of obesity as a serious community problem influence beliefs about causes of the problem .',
  '[ Obese but malnourished : a serious problem in Latin America ] .',
  'With obesity and excess weight remaining a serious concern worldwide , investigating the mechanisms underlying this is of great importance .',
  'In the last years , type 2 diabetes mellitus ( T2DM ) and obesity have become a serious public health problem , behaving as epidemic diseases .',
  'Rising levels of childhood obesity present a serious global public health problem amounting to 7 \xa0 % of GDP in developed countries and affecting 14 \xa0 % of children .',
  'Obesity is a serious problem in the United States and is associated with hypertension , diabetes , and other health problems such as heart disease and some forms of cancer .',
  'Obesity , a major risk factor for chronic diseases such as type 2 diabetes ( T2D ) , represents a serious primary health problem worldwide .',
  'Obesity in human populations , currently a serious health concern , is considered to be the consequence of an energy imbalance in which more energy in calories is consumed than is expended .',
  'Obesity is a serious public health concern with an increasing prevalence worldwide .',
  'Obesity is a serious public health problem , the prevalence of which is increasing dramatically all over the world .',
  'Obesity has become a serious epidemic health problem in both developing and developed countries .',
  'Child overweight/obesity continues to be a serious public health problem in high-income countries .',
  'Obesity has become a serious public health problem in the developed world .',
  'Body fatness is a serious problem starting in early childhood in CAH patients and further refinement of the glucocorticoid replacement regimens as well as lifestyle measures are needed .'],
 'pain': ['Back pain is one of the most common and costly health disorders in Germany.',
  'Despite numerous guidelines, nearly one of two patients with cancer pain remains undertreated, thereby affecting their quality of life.',
  'The efficacy of percutaneous intradiscal radiofrequency thermocoagulation (PIRFT) for the treatment of discogenic low back pain (LBP) remains controversial.',
  'Chronic non-specific low back is the most common musculoskeletal complaint that significantly affects the general population.',
  'Hospital admissions for patients with back pain are increasing.',
  'Neuropathy is a common diabetic complication that can result in significant disability.',
  'Hamstring tightness induces posterior pelvic tilt and decreased lumbar lordosis, which can result in low back painOBJECTIVE: We investigated effects of hamstring stretch with pelvic control on pain and work ability in standing workers.',
  'The management of breakthrough pain (BTP) in cancer patients is a challenge.',
  'Breakthrough pain (BTP) arising due to rib metastasis is very distressing and often very difficult to manage by titration of traditional analgesics',
  'Neuropathic pain is an abnormal pain, which is related to the activation of extracellular-regulated kinase (ERK) signaling',
  'Diverse pain killers used for the management of varied categories of pain are being misused in order to have extreme pleasant effect by a large number of populations',
  'Guillain-Barré syndrome (GBS) is a postinfectious immune-mediated peripheral neuropathy',
  'Breakthrough pain is an exacerbation of pain occurring in patients with chronic pain who receive opioid therapy every day',
  'A major problem with estimating the impact of chronic generalized pain is that the term remains undefined .',
  'A problem that is encountered in patients with low back pain is that a definite diagnosis is rare .',
  'Capecitabine , as the first-line treatment for multiple tumor types , has a serious drawback of hand-foot-syndrome ( HFS ) that limits its clinical use .',
  'Un(der)diagnosed and un(der)treated pain is a serious and frequent problem in persons with dementia .',
  'Chronic pain is a serious public health problem that has grown exponentially in recent years , which is why it has received the attention of numerous researchers .',
  'The skeletal pain control is a serious problem and it is a great responsibility also for the Urologists especially if the patient has not a short survival time and the quality of life very poor .',
  'Low back pain ( LBP ) is common in adult population , and it is becoming a serious health concern in adolescents .',
  'Collinearity diagnosis showed that there was a severe collinearity problem among the potential risk factors of low back pain .',
  'In a baseline assessment of 30 rural villages surrounding Shigatse City , Tibet , many people , especially women , identified low back pain as a serious health problem .',
  'Neuroma is usually accompanied by neuropathic pain , which is usually resistant to most analgesics and presents a serious clinical problem .',
  'Neuropathic pain is a serious clinical problem that needs to be solved urgently .',
  'Chronic pain is a serious problem in Spain .',
  'Neuropathic pain is a severe health problem for which there is a lack of effective therapy .',
  'The insufficient pain relief provided by current pharmacotherapy for chronic neuropathic pain is a serious medical problem .',
  'Our findings confirm that back pain represents a serious concern among teachers .',
  'Neuropathic pain is a severe health problem for which there is a lack of effective therapy .',
  'They desired recognition of having a serious back problem and of being more than the diagnosis itself .',
  'Chronic pain is a serious health problem with high rates of health care utilization ( HCU ) .',
  'Pain is a serious problem for infants and children and treatment options are limited .',
  'Pain lasting more than several hours may represent a serious problem .',
  'Chronic pain is a debilitating and rather common health problem .',
  'Low back pain represents a serious public health problem .',
  'The skeletal pain control is a serious problem and it is a great responsibility also for the Urologists especially if the patient has not a short survival time and the quality of life is very poor .',
  'Pain is a troublesome problem in multiple myeloma ( MM ) patients which may be affected by several pain syndromes sustained by different underlying causes and mechanisms- In this setting may be due to the disease itself , to its complications , to diagnostic procedures and therapeutic interventions .',
  'Neuropathic pain is a serious clinical problem to be solved .',
  'low back pain is a serious public health problem in particular among motorcycle drivers in our country where riding a motorcycle is becoming more and more a work to bring assistance to the population facing growing unemployment .',
  'Not only is persistent pain a debilitating health problem for older adults , it also may have negative effects on family relationships .',
  'Overpowering pain . A serious problem comes out of the closet .',
  'Back injuries are a serious problem for nursing personnel who perform frequent patient-handling activities .',
  'Bone cancer pain ( BCP ) remains a serious complication of malignancy , which is an intractable clinical problem due to the gap in knowledge of its underlying mechanisms .',
  'Back pain in a pediatric patient can present a worrisome and challenging diagnostic dilemma for any physician .',
  'Pain is a serious and multidimensional problem among institutionalized stroke patients .',
  'It is currently estimated that the lack of adequate pain management affects 80 % of the global population and the phenomenon poses a serious problem in more than 150 countries .',
  'Pain in patients with hemophilia is a serious problem that negatively affects their quality of life , including their working capacity .',
  'Persistent pain is a serious problem that often contributes to a poor quality of life in pancreatic cancer patients .',
  'However , there have been very few studies on the impact of Hsp90 inhibitors on pain or analgesia , a serious concern for cancer patients .',
  'Chronic pain is a serious public health problem that affects people of all ages and backgrounds .',
  'The outcome of peripheral nerve injury is often impaired by neuropathic pain , which is resistant to most analgesics and presents a serious clinical problem .',
  'Neuropathic pain is a severe and disabling health problem , often difficult to treat and characterized by specific somatosensory signs and symptoms .',
  'Neuropathic pain constitutes a serious therapeutic problem .',
  'Chronic low back pain ( CLBP ) is a serious health problem in industrialised countries and the efficacy of current treatment options is unsatisfying .',
  'In patients with advanced cancer , cancer-induced bone pain ( CIBP ) is a severe and common problem that is difficult to manage and explain .',
  'Neuropathic pain is a debilitating clinical problem and difficult to treat .',
  'Inadequate pain monitoring and management in hospitalized patients poses a serious clinical problem which has been extensively covered in literature for over 25 years .',
  'Neuropathic pain , resulting from the pathological changes of the somatosensory nervous system , remains a severe public health problem worldwide .',
  'Cancer pain is a serious health problem , and imposes a great burden on the lives of patients and their families .',
  'Chronic neuropathic pain constitutes a serious public health problem , but the disease mechanisms are only partially understood .',
  'GOALS AND WORK : Despite medical awareness , intractable pain is a serious problem in cancer and occurs in up to 2 % of advanced cancer patients .',
  'Unrelieved pain is a serious clinical problem that has received little attention in bioethics .',
  'Inadequate pain management is a serious public health problem that affects a wide cross-section of Americans .',
  'Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources .',
  'Neuropathic pain , resulting from nervous system injury or dysfunction , can be a serious medical problem and especially difficult to treat .',
  'Chronic pain is a debilitating and increasingly common medical problem with few effective treatments .',
  'Neuropathic pain concurrent with mood disorder from peripheral nerve injury is a serious clinical problem that significantly affects quality of life .',
  'Chronic pain is a serious health concern and potentially debilitating condition , leading to anxiety , depression , reduced productivity and functionality , and poor quality of life .',
  'Mostly assigning the pain origin to the nonfused fragment is easy though , in few cases , can be a serious dilemma , especially in the absence of direct tenderness over nonfused fragment .',
  'Effective pain management remains a serious problem in the nursing home setting .',
  'Under-diagnosis of pain is a serious problem in cancer care .',
  'Pain can be a serious problem in patients with Guillain-Barré syndrome ( GBS ) .',
  'Chronic pain is a serious health problem given its prevalence , associated disability , impact on quality of life and the costs associated with the extensive use of health care services by individuals living with it .',
  'Although the pain in your back may be severe , most low back pain is not due to a serious problem .',
  'The results provide additional evidence that back pain is a serious problem in children aged 11 - 14 years , whilst also indicating widespread co-occurrence of pain in the neck , upper back and lower back spinal regions .',
  'It is widely recognized that back pain is a serious problem within the nursing profession .',
  'Such frequent occurrence of back pain syndromes is a serious medical and social problem .',
  'The incidence of chronic pain amongst elderly people in nursing homes is very high , making pain in this population a serious problem for aged care facilities .',
  'Discogenic low back pain is a serious medical and social problem , and accounts for 26%-42 % of the patients with chronic low back pain .',
  'Persistent non-cancer pain is a serious problem .',
  'Back pain poses a serious clinical problem in some cases , because under the clinical symptoms of back pain might be other hidden diseases .',
  'Low back pain ( LBP ) is a debilitating problem worldwide causing disability and reducing quality of life .',
  'Pain is a serious health problem that is commonly treated with opioids , although the doses of opioids needed to treat pain are often similar to those that decrease respiration .',
  "Dementia 's impact on pain sensation : a serious clinical dilemma for dental geriatric care givers .",
  'The findings of our study indicate that patient compliance with back pain treatment is a serious and complex problem .',
  'In surviving patients , chronic pain may be a serious problem , but the long term incidence and potential risk factors are not very well studied .',
  'Chronic pain is a debilitating problem for many Americans .',
  'Cancer-induced bone pain remains a serious public health concern , with a need for translational behavioural tests in order to assess nociception in preclinical models of this condition .',
  'Assessment tools increase the options available when pain is a serious problem .',
  'As chronic pain is a severe problem in clinics , study of the mechanisms of chronic pain and development of novel analgesic agents is of significance .',
  'Fibromyalgia has become a serious social problem in the well developed countries in the recent years .',
  'Back pain disability is a serious and costly problem affecting the nursing profession .',
  'Chronic pain is a debilitating syndrome caused by a variety of disorders , and represents a major clinical problem because of the lack of adequate medication .',
  'Forty-nine percent of federal physicians and 58 % of state physicians reported that torture is a severe problem for detainees in Mexico .',
  'Chronic noncancer pain is a serious health problem , one that is often associated with physical debility and emotional suffering .',
  'Chronic pain is a debilitating and pervasive health problem , particularly among older adults .',
  'Neuropathic pain is a severe problem that is difficult to treat clinically .',
  'Neuropathic pain , resulting from somatosensory nervous system dysfunction , remains a serious public health problem worldwide .',
  'Chronic pain and associated disability is a serious problem for a significant number of adolescents .',
  'Chronic pain is a serious problem for many older people , yet its management in this population is often less than satisfactory .',
  'Pain is a debilitating problem that is common to most patients with cancer at some time during the course of their disease .',
  'Chronic pain management represents a serious healthcare problem worldwide .',
  'The direct and indirect costs of low back pain approach $ 24 billion per year in the U.S. It is in view of its high prevalence among populations of developed countries , of its heavy psychosocial and financial implications , and of the burden imposed on health services , that low back pain represents a severe public health problem .',
  'Although the undertreatment of pain among persons with cognitive impairments represents a serious ethical concern for pain clinicians , most writers in the area explain the undertreatment of pain by focusing on issues related to liability , fears of addiction to opioids , and erroneous beliefs that pain is a normal part of the ageing process .',
  'Low back disorders pose a serious health problem among workers engaged in heavy manual lifting and carrying .',
  'Trigeminal neuralgia ( TN ) is a serious health problem , causing brief , recurrent episodes of stabbing or burning facial pain , which patients describe as feeling like an electric shock .',
  'Topics covered include the initial assessment of patients presenting with acute low back problems , identification of red flags that may indicate the presence of a serious underlying medical condition , initial management , special studies and diagnostic considerations , and further management considerations .',
  'Chronic widespread pain is a serious medical problem , yet the mechanisms of nociception and pain are poorly understood .',
  'Pediatric debilitating chronic pain is a severe health problem , often requiring complex interventions such as intensive interdisciplinary pain treatment ( IIPT ) .',
  'Peripheral neuropathy ( PN ) is a serious problem affecting more than 22 million people in the United States , according to The Pacific Chapter of the Neuropathy Association .',
  'These findings indicate that chronic pain is a serious secondary problem in individuals with SCI and underscore the need for further research aimed at delineating the causes of , and optimal treatments for , the various pain problems in this population .',
  'Treatment of neuropathic pain ( NP ) is a serious medical problem .',
  "Chronic non-specific low back pain syndrome ( cnsLBP ) is a severe health problem in developed countries , which has an important effect on patients ' quality of life and is highly determined by socio-demographic factors and low back pain specific knowledge .",
  'Pain is one of the common and debilitating health manifestations associated with the majority of diseased conditions , thus making it a serious health concern worldwide .',
  'Pain is a serious health problem that impacts the lives of many individuals .',
  'Out of 52 patients ( 57.1 % ) with neuropathy , 30 ( 57.7 % ) had a severe problem .',
  'Work-related low back pain is a serious socioeconomic problem .',
  'These results indicate that musculoskeletal pain is relatively common among the very old , but does not seem to be a severe problem for the majority , considering the low proportion of subjects using prescription analgesics regularly .',
  'The persistence of back pain following acute back " sprains " is a serious public health problem with poorly understood pathophysiology .',
  'Work-related lower back disorders , which involve the lumbo-sacral region , as well as injuries of the lumbar section of the spine , are a serious and constantly growing problem in Europe .',
  'Neuropathic pain is a serious public health problem and has a strong affective-motivational component that makes it difficult to treat .',
  'Chronic low back pain ( CLBP ) and chronic neck pain ( CNP ) have become a serious medical and socioeconomic problem in recent decades .',
  'Low back pain ( LBP ) is common in adult population , and it is becoming a serious health concern in adolescents .',
  'Back pain in children is a rare condition but may denote a serious health problem ; hence , full clinical history , physical examination , and appropriate laboratory studies should be obtained .',
  'Lower back pain is a serious health problem , and this review article will help educate physicians and physiotherapists dealing with LBP in the options of evidence-based treatment .',
  'It is currently estimated that the lack of adequate pain management affects 80 % of the global population and the phenomenon poses a serious problem in more than 150 countries .',
  'Pain is a serious health care problem and there is growing evidence to support the use of hypnosis and cognitive-behavioral interventions for pain management .',
  'Injury-induced neuropathic pain remains a serious clinical problem .',
  'Although prevalence figures from other studies vary widely , partly due to the populations chosen , all of the studies verify that breakthrough pain is a serious problem in cancer patients .',
  'Reduced balance with visual deprivation might be a physical indicator of a serious back problem .',
  'Pharmacists in North Carolina are aware that the undertreatment of cancer pain is a serious medical problem .',
  'Neuropathic pain is a severe clinical problem , often appearing as a co-symptom of many diseases or manifesting as a result of damage to the nervous system .',
  'Pain continues to be a serious health care concern in the United States .',
  'Chronic pain is a serious public health problem and is treated by diverse health care providers .',
  'Chronic low back pain is a serious global health problem .',
  'Pain in differing parts of the body is a serious problem in the German population .',
  'Chronic musculoskeletal pain ( CMP ) is a serious health concern especially among the elderly population and has significant bearing on health and quality of life .',
  'At the moment there are more than 40 framesaws in use in Croatia , and many framesaw operators have a serious spine problem .',
  'Low back pain ( LBP ) is a serious health problem among medical students .',
  'Postherpetic neuralgia ( PHN ) is a vexing problem occurring in 10 to 20 percent of people with from herpes zoster ( shingles ) .',
  'However , there have been very few studies on the impact of Hsp90 inhibitors on pain or analgesia , a serious concern for cancer patients .',
  'Musculoskeletal pain is a debilitating problem treated with image-guided corticosteroid injections .',
  'Back pain is a serious medical problem especially for those people sitting over long periods during their daily work .',
  'Sensory polyneuropathy can be a serious problem , but for the majority of clinically important neuropathies there are no available therapies .',
  'Pain remains a serious health care problem affecting millions of individuals , costing billions of dollars , and causing an immeasurable amount of human suffering .',
  'Waiting list management at chronic pain clinics has become a serious problem throughout Canada .',
  "Low back injury is a serious problem for U.S. industries , accounting for as much as one third of all workers ' compensation payments .",
  'Low back pain in children and adolescents is often caused by a serious problem .',
  'Undertreatment of pain continues to be a serious public health problem .',
  'Cancer pain is a serious problem that requires specialized nursing knowledge .',
  'Although paclitaxel is a frontline antineoplastic agent for treatment of solid tumors , the paclitaxel-evoked pain syndrome is a serious problem for patients .',
  'There is accumulating evidence that recurring pain symptoms in children are becoming a serious health concern .',
  'According to a 1992 report from The Agency for Health Care Policy Research ( AHCPR ) , the " ethical obligation to manage pain and relieve the patient \'s suffering is at the core of a health care professional \'s commitment . " However , despite the increased emphasis on the ethical duty to relieve pain , the undertreatment of pain continues to be a serious problem .',
  'In particular , neuropathic pain ( e.g. , postherpetic and trigeminal neuralgia , diabetic neuropathy and spinal cord injury ) is a serious clinical problem that affects a high percentage of the world population .',
  'Chronic pain remains a serious public health problem worldwide .',
  "Untreated pain in people with Alzheimer 's disease continues to be a serious public health problem .",
  'Back pain is a common condition which has been described as a serious public health problem .',
  "Besides , being extra to NSAID opioid was given to 14.1 % ( n=59 ) of the patients by 95.5 % ( n=416 ) intramuscular approach and 62.9 % ( n=293 ) of the patients , whose pains were not over in spite of the pain treatment Based on these results , trauma patients ' pains still have n't been handled as a serious problem .",
  'An excessive lumbar load with snow-shoveling is a serious problem in snowfall areas .'],
 'rape': ['The #MeToo social media campaign in the United States has highlighted what is a pervasive problem in many cultures-the sexual intimidation and victimization of women by men, especially those in roles of authority.',
  'Sexual violence against women is a serious problem worldwide .',
  'Also , sexual harassment was perceived as a serious problem ( 19.4 % ) and education was necessary for prevention ( 88.3 % ) .',
  'Rape is a serious concern globally .',
  'Sexual assault is a serious problem on college campuses .',
  'Sexual aggression ( SA ) is a serious public-health problem on college campuses , and there is a pressing need for basic research fostering the development of novel prevention strategies .',
  'Date rape ( DR ) is a serious but under-recognized public health problem that affects female university undergraduates .',
  'The results indicate that rape against women is a serious public health problem in Dar es Salaam commonly involving people who are close to the victims .',
  'Sexual violence is a serious public health problem that has been associated with negative mental and physical health outcomes .',
  'LGBT homicides are typically hate crimes and constitute a serious public health problem because they affect young people , particularly transgender people .',
  'Sexual assault is a serious concern on college and university campuses across the United States .',
  'Alcohol-facilitated sexual assault is a serious problem on college campuses , and bystander intervention has been shown to be a successful method in reducing sexual assaults .',
  'Revenge pornography , also known as nonconsensual pornography , is a subtype of cyberharassment/cyberstalking , and a serious problem facing society in the Internet age .',
  'Finally , perceptions of harassment as a serious problem in campuses related to a higher likelihood of intervening as a bystander .',
  'Sexual violence ( SV ) represents a serious public health problem with high rates and numerous health consequences .',
  'Sexual assault is a serious social problem that affects the lives of many women , men , and children .',
  'Sexual offending is a serious social problem , a public health issue , and a major challenge for social policy .',
  'Sexual violence is a serious and costly public health problem .',
  'Thus , sexual coercion is a serious and prevalent concern among female Indian psychiatric patients , but is rarely reported in medical charts .',
  'Survey data showed that 94 % believed that it was a serious problem ; 89 % felt that it violated the rights of girls and women and 81 % supported criminalization .',
  'Sexual assault poses a serious health problem to both the survivor and the health system .',
  'Antigay hate crimes ( words or actions that are intended to harm or intimidate individuals because they are lesbian or gay ) constitute a serious national problem .',
  'Sexual assault is a serious social problem that constitutes serious health conditions affecting the lives of involved individuals .',
  'Sexual violence is a severe public health problem that requires implementing specific programs to sensitize and train healthcare providers to prevent it .',
  "Sexual assault is a serious social problem that affects women 's life .",
  'A serious concern is the disparity between the number of those who met the behavioral criteria for rape victimization based on the current legal definition , but who',
  'Sexual aggression is a serious societal problem , yet treatments for sexual aggressors have generally been ineffective in part because of the lack of unified theories to guide treatment .'],
 'rhinosinusitis': ['Chronic rhinosinusitis is a common nasal disorder in children that is prone to recurrence.',
  'Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in Germany and is often accompanied by years of chronic rhinosinusitis.',
  'Infections of the lower airways pose a serious problem for the health service , both because of the burden of the disease and because of the large number of resources that need to be devoted to treating it .',
  'Infectious respiratory diseases are a serious health concern worldwide .',
  'Diseases of respiratory organs constitute a serious socio-medical problem in this country due to high morbidity , mortality , and disability rates .',
  'Respiratory tract infections still represent a serious medical problem , mainly in people with different dysfunctions of the immune system .',
  'Recurrent respiratory tract infections ( RRTIs ) in children constitute a serious problem worldwide .',
  'In conclusion , chronic respiratory infections and associated bronchiectasis remain a serious problem in Turkey due to insufficient prevention , diagnosis , and treatment .',
  'Lower respiratory tract infections in the intubated patient constitute a serious health problem due to their associated morbidity and mortality .',
  'In the study of inflammatory mechanisms in the upper respiratory tract , the unknown dilution of collected samples of nasal secretions poses a serious problem for interpretation of the measured concentrations of various substances in the specimens .',
  'The lower airway and genitourinary systems are frequently infected with multiresistant pathogens , and present a serious epidemiological problem .',
  'Improvement in health care of the young and antibiosis militate against tonsilloliths as a serious problem in the young patient .',
  'Respiratory tract infections ( RTIs ) represent a serious problem because they are one of the most common cause of human death by infection .',
  'Respiratory illness in children with disability : a serious problem ?'],
 'respiratory': ['Chronic rhinosinusitis is a common nasal disorder in children that is prone to recurrence.',
  'Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in Germany and is often accompanied by years of chronic rhinosinusitis.',
  'Etiologies contributing to failure to wean from mechanical ventilation (MV) are multiple, resulting in morbid and costly outcomes.',
  'The ability to monitor tissue oxygenation in neonates remains a challenge due to limited blood supply and the reliance on invasive procedures.',
  'Acute lung injury ( ALI ) and the subsequent multi-system organ failure is a serious health problem with devastating impacts on the health care systems .',
  'Acute lung injury ( ALI ) is a severe inflammatory condition that develops in response to local and systemic lung challenges .',
  'Prolonged support of organ functions without therapeutic benefit represents a serious problem of therapy in intensive care units ( ICUs ) .',
  'Acute respiratory distress syndrome continues to be a vexing clinical problem with no specific therapy .',
  'Massive unilateral pulmonary injury poses a severe ventilatory problem .',
  'With neonatal respiratory support using a heated humidifier , condensation following decreases in temperature within the unheated part of the inspiratory circuit represents a serious problem , due to the resulting drop in absolute humidity .',
  'Acute respiratory distress syndrome ( ARDS ) still represents a serious problem in clinical routine and is associated with a high mortality .',
  'Infections of the lower airways pose a serious problem for the health service , both because of the burden of the disease and because of the large number of resources that need to be devoted to treating it .',
  'Hypoxemia during one-lung ventilation ( OLV ) remains a serious problem , particularly in the supine position .',
  'Even though artificial surfactant is now available , respiratory distress syndrome still remains a serious problem in neonatology .',
  'Acute lung injury ( ALI ) is a serious clinical problem .',
  'Infectious respiratory diseases are a serious health concern worldwide .',
  'Patient-ventilator asynchrony is a serious problem that is associated with prolonged mechanical ventilation , prolonged ICU and hospital stays , and increased mortality .',
  'The acute respiratory distress syndrome ( ARDS ) remains a serious clinical problem with the current treatment being supportive in the form of mechanical ventilation .',
  'The acute respiratory distress syndrome ( ARDS ) is a serious and complex clinical problem that often threatens the lives of patients .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a serious neonatal problem which has a high mortality rate even with advanced modes of mechanical ventilation .',
  'Diseases of respiratory organs constitute a serious socio-medical problem in this country due to high morbidity , mortality , and disability rates .',
  'Because of this , lung immaturity is a serious problem in premature infants .',
  'Despite advances in neonatal care in the past 50 years , bronchopulmonary dysplasia , with all its adverse short-term and long-term consequences , is still a serious problem in neonatal care .',
  '1 . Acute lung injury ( ALI ) or acute respiratory distress syndrome is a serious clinical problem with high mortality .',
  '[ Pediatric acute respiratory distress syndrome : a severe problem than yet to be conquered by critical care medicine ] .',
  'Discriminating cardiogenic pulmonary edema ( CPE ) from acute respiratory distress syndrome ( ARDS ) is a serious problem in emergency departments , and the ability of chest radiographs to differentiate between these 2 entities is limited .',
  'Acute respiratory distress syndrome ( ARDS ) represents a serious problem in critically ill patients and is associated with in-hospital mortality rates of 33%-52 % .',
  'Diabetes is a devastating global health problem and is considered a predisposing factor for lung injury progression .',
  'Respiratory tract infections still represent a serious medical problem , mainly in people with different dysfunctions of the immune system .',
  'Neonatal respiratory failure ( RF ) is a serious clinical problem associated with high mortality .',
  'Acute lung injury ( ALI ) is a devastating clinical problem with a mortality as high as 60 % .',
  'Acute respiratory distress syndrome ( ARDS ) remains a serious clinical problem with the main treatment being supportive in the form of mechanical ventilation .',
  'Despite improvements in critical care , acute respiratory distress syndrome ( ARDS ) remains a devastating clinical problem with high rates of morbidity and mortality .',
  'Recurrent respiratory tract infections ( RRTIs ) in children constitute a serious problem worldwide .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Although ROP incidence did not increase during this review period , it remains a serious problem in high-risk premature infants in our Newborn Intensive Care Unit .',
  'Smoke inhalation leads to acute lung injury ( ALI ) , a devastating clinical problem associated with high mortality rates .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight ( VLBW ) infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'In conclusion , chronic respiratory infections and associated bronchiectasis remain a serious problem in Turkey due to insufficient prevention , diagnosis , and treatment .',
  'Lower respiratory tract infections in the intubated patient constitute a serious health problem due to their associated morbidity and mortality .',
  'Acute respiratory distress syndrome ( ARDS ) is a serious clinical problem that has a 30 - 50 % mortality rate .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Acute lung injury or acute respiratory distress syndrome is a serious clinical problem with high mortality .',
  'Bronchopulmonary dysplasia ( BPD ) is a serious and common problem among very low birth weight infants , despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Ventilator-associated pneumonia is a serious problem which needs to be addressed for a better outcome of the ventilated babies .',
  'In the study of inflammatory mechanisms in the upper respiratory tract , the unknown dilution of collected samples of nasal secretions poses a serious problem for interpretation of the measured concentrations of various substances in the specimens .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a severe clinical problem among neonatal intensive care unit ( NICU ) patients .',
  'The lower airway and genitourinary systems are frequently infected with multiresistant pathogens , and present a serious epidemiological problem .',
  'Improvement in health care of the young and antibiosis militate against tonsilloliths as a serious problem in the young patient .',
  'Respiratory tract infections ( RTIs ) represent a serious problem because they are one of the most common cause of human death by infection .',
  'Smoke inhalation leads to acute lung injury ( ALI ) , a devastating clinical problem associated with high mortality .',
  'Acute respiratory distress syndrome ( ARDS ) causes a heterogeneous lung injury and remains a serious medical problem , with one of the only treatments being supportive care in the form of mechanical ventilation .',
  'Respiratory illness in children with disability : a serious problem ?'],
 'nasal': ['Chronic rhinosinusitis is a common nasal disorder in children that is prone to recurrence.',
  'Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in Germany and is often accompanied by years of chronic rhinosinusitis.',
  'Infections of the lower airways pose a serious problem for the health service , both because of the burden of the disease and because of the large number of resources that need to be devoted to treating it .',
  'Infectious respiratory diseases are a serious health concern worldwide .',
  'Diseases of respiratory organs constitute a serious socio-medical problem in this country due to high morbidity , mortality , and disability rates .',
  'Respiratory tract infections still represent a serious medical problem , mainly in people with different dysfunctions of the immune system .',
  'Recurrent respiratory tract infections ( RRTIs ) in children constitute a serious problem worldwide .',
  'In conclusion , chronic respiratory infections and associated bronchiectasis remain a serious problem in Turkey due to insufficient prevention , diagnosis , and treatment .',
  'Lower respiratory tract infections in the intubated patient constitute a serious health problem due to their associated morbidity and mortality .',
  'In the study of inflammatory mechanisms in the upper respiratory tract , the unknown dilution of collected samples of nasal secretions poses a serious problem for interpretation of the measured concentrations of various substances in the specimens .',
  'The lower airway and genitourinary systems are frequently infected with multiresistant pathogens , and present a serious epidemiological problem .',
  'Improvement in health care of the young and antibiosis militate against tonsilloliths as a serious problem in the young patient .',
  'Respiratory tract infections ( RTIs ) represent a serious problem because they are one of the most common cause of human death by infection .',
  'Respiratory illness in children with disability : a serious problem ?'],
 'nursing': ['The importance of non-technical skills (NTS) to patient outcomes is increasingly being recognised, however, there is limited research into how such skills can be taught and evaluated in student nurses in relation toward rounds.',
  'Although care is understood as the essence of nursing, it is often difficult for nurses to provide care, which demonstrates a contradiction between theory and practice.',
  'A limited pool of nurse faculty has affected enrollment of nursing students and the ability to produce the nursing workforce needed for the evolving health care system',
  'Nurse preceptors have varying backgrounds of teaching experience and often cite insufficient preparation as a common reason for difficulties transitioning from the role of clinician to educator',
  'There are few opportunities for nurse practitioner (NP) students to develop relationships and exchange ideas with international counterparts',
  'The role of the advanced nurse practitioner (ANP) is not regulated in the UK, which has led to wide variation in the skills, competencies and academic qualifications of nurses using this title',
  'Patient advocacy is central to the nursing profession yet a sense of certainty about the concept, its meaning and its implications for nursing practice remains elusive',
  'One problem with the vocational model , as it has historically applied to nursing , is that it has been articulated through concepts of motherhood .',
  'The problem with subsidies is that nurses who receive subsidized educations are able to provide nursing services for less compensation because they paid less or nothing for their educations .',
  'A problem with this literature is that a sizable portion of it is unbalanced in its support of nurse influence and in its opposition to hospital bureaucracy .',
  'The problem with separating nursing care from personal care ( perspectives March 14 ) is that it overlooks that this is an artificial and unnecessary construct .',
  'Faculty attrition , particularly among female and minority faculty , is a serious problem in academic medical settings .',
  'Staff turnover is a serious concern in nursing homes as it has been found to adversely affect care . When employee turnover is minimized , better care quality is more likely in nursing homes .',
  'For foreign nurses , the practice is often an opportunity to make a better life for themselves and their families . And it helps solve a serious problem for the U.S. organizations involved . But the recruitment of foreign nurses raises a number of ethical questions .',
  "Registered nurse ( RN ) turnover is a severe problem many hospitals face in today 's health care climate .",
  'A serious shortage of registered nurses at four hospitals in the Moira Shire in northern Victoria resulted in these communities forming the Moira Nurse Education Consortium to address this problem .',
  'This study brings light to a severe problem of nurse retention in Portugal .',
  'This study has been performed in undergraduate , graduate , and clinical graduate nursing faculty-suggesting a serious concern in clinical nursing education and clinical practice to meet the complex care needs of the largest , fastest-growing , and costliest U.S. patient population-those with MCCs .',
  'Nurse turnover is a serious problem , especially given the increased need for professional medical care because of demographic changes , and puts severe pressure on health-care management staff .',
  'Retention in nursing and midwifery programmes is a serious international problem .',
  'Nurse leaving is a serious international problem as it contributes to the nursing shortage that threatens the welfare of society .',
  'Attrition from nursing programmes is a serious problem in the UK .',
  'Prior to the economic recession of 2007 - 2010 , the growing shortage of nurses in New Zealand presented a serious concern for the healthcare workforce . Given the ageing New Zealand nursing workforce , an ageing population and the increasing demands for health care , it is imperative that issues of retention of Generation Y nurses are resolved prior to the imminent retirement of more experienced nurses .',
  'There is no doubt that the healthcare environment provides a complex and frustrating working climate for the most dedicated professional employee , and the cost of absenteeism and turnover is a serious problem for healthcare administrators .',
  'British nursing has yet to take a noticeably visible role in this debate , despite the fact that it poses a serious dilemma for a profession whose cultural ethos has been shaped by the concepts of universal access and comprehensiveness of care and is wedded to the idea of holism .',
  'The global nursing shortage and statistics indicating a steady increase in the cancer patient workload suggest that the recruitment and retention of oncology nurses is and will be a serious problem .',
  'Turnover in health care is a serious concern , as it contributes to the global nursing shortage and is associated with declines in quality of care , patient safety and patient outcomes .',
  'Insecurity in medical education : a preventable problem ?',
  'Although nurse turnover is a serious problem , the fact that each nurse has different work-related needs/values , and leaves their job for different reasons makes it difficult for organisations to develop effective countermeasures against it .',
  'There is a serious and growing shortage of nurses in the United States , and the high rate of student attrition from nursing programs has further added to this problem .',
  '[ Congress of the Swiss Nursing Association in Montreux : if interdisciplinary cooperation is not only a slogan but a serious concern , it demands an honest effort from everyone involved ] .',
  'There is a dire need of adopting a systematic approach to faculty development to enhance quality education to meet health challenges for 21st Century .',
  'Despite compelling evidence that there was a serious problem with the management of critically ill patients in the ward environment , there is little evidence to support outreach as a concept or as a role for nurse consultants .',
  'The use of group testing that predicts success in understanding and using the nursing process suggests a tempting solution to a vexing problem : selecting those students from an applicant pool who have the potential to successfully complete a nursing program .'],
 'nurse': ['The importance of non-technical skills (NTS) to patient outcomes is increasingly being recognised, however, there is limited research into how such skills can be taught and evaluated in student nurses in relation toward rounds.',
  'Although care is understood as the essence of nursing, it is often difficult for nurses to provide care, which demonstrates a contradiction between theory and practice.',
  'A limited pool of nurse faculty has affected enrollment of nursing students and the ability to produce the nursing workforce needed for the evolving health care system',
  'Nurse preceptors have varying backgrounds of teaching experience and often cite insufficient preparation as a common reason for difficulties transitioning from the role of clinician to educator',
  'There are few opportunities for nurse practitioner (NP) students to develop relationships and exchange ideas with international counterparts',
  'The role of the advanced nurse practitioner (ANP) is not regulated in the UK, which has led to wide variation in the skills, competencies and academic qualifications of nurses using this title',
  'Patient advocacy is central to the nursing profession yet a sense of certainty about the concept, its meaning and its implications for nursing practice remains elusive',
  'One problem with the vocational model , as it has historically applied to nursing , is that it has been articulated through concepts of motherhood .',
  'The problem with subsidies is that nurses who receive subsidized educations are able to provide nursing services for less compensation because they paid less or nothing for their educations .',
  'A problem with this literature is that a sizable portion of it is unbalanced in its support of nurse influence and in its opposition to hospital bureaucracy .',
  'The problem with separating nursing care from personal care ( perspectives March 14 ) is that it overlooks that this is an artificial and unnecessary construct .',
  'Faculty attrition , particularly among female and minority faculty , is a serious problem in academic medical settings .',
  'Staff turnover is a serious concern in nursing homes as it has been found to adversely affect care . When employee turnover is minimized , better care quality is more likely in nursing homes .',
  'For foreign nurses , the practice is often an opportunity to make a better life for themselves and their families . And it helps solve a serious problem for the U.S. organizations involved . But the recruitment of foreign nurses raises a number of ethical questions .',
  "Registered nurse ( RN ) turnover is a severe problem many hospitals face in today 's health care climate .",
  'A serious shortage of registered nurses at four hospitals in the Moira Shire in northern Victoria resulted in these communities forming the Moira Nurse Education Consortium to address this problem .',
  'This study brings light to a severe problem of nurse retention in Portugal .',
  'This study has been performed in undergraduate , graduate , and clinical graduate nursing faculty-suggesting a serious concern in clinical nursing education and clinical practice to meet the complex care needs of the largest , fastest-growing , and costliest U.S. patient population-those with MCCs .',
  'Nurse turnover is a serious problem , especially given the increased need for professional medical care because of demographic changes , and puts severe pressure on health-care management staff .',
  'Retention in nursing and midwifery programmes is a serious international problem .',
  'Nurse leaving is a serious international problem as it contributes to the nursing shortage that threatens the welfare of society .',
  'Attrition from nursing programmes is a serious problem in the UK .',
  'Prior to the economic recession of 2007 - 2010 , the growing shortage of nurses in New Zealand presented a serious concern for the healthcare workforce . Given the ageing New Zealand nursing workforce , an ageing population and the increasing demands for health care , it is imperative that issues of retention of Generation Y nurses are resolved prior to the imminent retirement of more experienced nurses .',
  'There is no doubt that the healthcare environment provides a complex and frustrating working climate for the most dedicated professional employee , and the cost of absenteeism and turnover is a serious problem for healthcare administrators .',
  'British nursing has yet to take a noticeably visible role in this debate , despite the fact that it poses a serious dilemma for a profession whose cultural ethos has been shaped by the concepts of universal access and comprehensiveness of care and is wedded to the idea of holism .',
  'The global nursing shortage and statistics indicating a steady increase in the cancer patient workload suggest that the recruitment and retention of oncology nurses is and will be a serious problem .',
  'Turnover in health care is a serious concern , as it contributes to the global nursing shortage and is associated with declines in quality of care , patient safety and patient outcomes .',
  'Insecurity in medical education : a preventable problem ?',
  'Although nurse turnover is a serious problem , the fact that each nurse has different work-related needs/values , and leaves their job for different reasons makes it difficult for organisations to develop effective countermeasures against it .',
  'There is a serious and growing shortage of nurses in the United States , and the high rate of student attrition from nursing programs has further added to this problem .',
  '[ Congress of the Swiss Nursing Association in Montreux : if interdisciplinary cooperation is not only a slogan but a serious concern , it demands an honest effort from everyone involved ] .',
  'There is a dire need of adopting a systematic approach to faculty development to enhance quality education to meet health challenges for 21st Century .',
  'Despite compelling evidence that there was a serious problem with the management of critically ill patients in the ward environment , there is little evidence to support outreach as a concept or as a role for nurse consultants .',
  'The use of group testing that predicts success in understanding and using the nursing process suggests a tempting solution to a vexing problem : selecting those students from an applicant pool who have the potential to successfully complete a nursing program .'],
 'nurses': ['The importance of non-technical skills (NTS) to patient outcomes is increasingly being recognised, however, there is limited research into how such skills can be taught and evaluated in student nurses in relation toward rounds.',
  'Although care is understood as the essence of nursing, it is often difficult for nurses to provide care, which demonstrates a contradiction between theory and practice.',
  'A limited pool of nurse faculty has affected enrollment of nursing students and the ability to produce the nursing workforce needed for the evolving health care system',
  'Nurse preceptors have varying backgrounds of teaching experience and often cite insufficient preparation as a common reason for difficulties transitioning from the role of clinician to educator',
  'There are few opportunities for nurse practitioner (NP) students to develop relationships and exchange ideas with international counterparts',
  'The role of the advanced nurse practitioner (ANP) is not regulated in the UK, which has led to wide variation in the skills, competencies and academic qualifications of nurses using this title',
  'Patient advocacy is central to the nursing profession yet a sense of certainty about the concept, its meaning and its implications for nursing practice remains elusive',
  'One problem with the vocational model , as it has historically applied to nursing , is that it has been articulated through concepts of motherhood .',
  'The problem with subsidies is that nurses who receive subsidized educations are able to provide nursing services for less compensation because they paid less or nothing for their educations .',
  'A problem with this literature is that a sizable portion of it is unbalanced in its support of nurse influence and in its opposition to hospital bureaucracy .',
  'The problem with separating nursing care from personal care ( perspectives March 14 ) is that it overlooks that this is an artificial and unnecessary construct .',
  'Faculty attrition , particularly among female and minority faculty , is a serious problem in academic medical settings .',
  'Staff turnover is a serious concern in nursing homes as it has been found to adversely affect care . When employee turnover is minimized , better care quality is more likely in nursing homes .',
  'For foreign nurses , the practice is often an opportunity to make a better life for themselves and their families . And it helps solve a serious problem for the U.S. organizations involved . But the recruitment of foreign nurses raises a number of ethical questions .',
  "Registered nurse ( RN ) turnover is a severe problem many hospitals face in today 's health care climate .",
  'A serious shortage of registered nurses at four hospitals in the Moira Shire in northern Victoria resulted in these communities forming the Moira Nurse Education Consortium to address this problem .',
  'This study brings light to a severe problem of nurse retention in Portugal .',
  'This study has been performed in undergraduate , graduate , and clinical graduate nursing faculty-suggesting a serious concern in clinical nursing education and clinical practice to meet the complex care needs of the largest , fastest-growing , and costliest U.S. patient population-those with MCCs .',
  'Nurse turnover is a serious problem , especially given the increased need for professional medical care because of demographic changes , and puts severe pressure on health-care management staff .',
  'Retention in nursing and midwifery programmes is a serious international problem .',
  'Nurse leaving is a serious international problem as it contributes to the nursing shortage that threatens the welfare of society .',
  'Attrition from nursing programmes is a serious problem in the UK .',
  'Prior to the economic recession of 2007 - 2010 , the growing shortage of nurses in New Zealand presented a serious concern for the healthcare workforce . Given the ageing New Zealand nursing workforce , an ageing population and the increasing demands for health care , it is imperative that issues of retention of Generation Y nurses are resolved prior to the imminent retirement of more experienced nurses .',
  'There is no doubt that the healthcare environment provides a complex and frustrating working climate for the most dedicated professional employee , and the cost of absenteeism and turnover is a serious problem for healthcare administrators .',
  'British nursing has yet to take a noticeably visible role in this debate , despite the fact that it poses a serious dilemma for a profession whose cultural ethos has been shaped by the concepts of universal access and comprehensiveness of care and is wedded to the idea of holism .',
  'The global nursing shortage and statistics indicating a steady increase in the cancer patient workload suggest that the recruitment and retention of oncology nurses is and will be a serious problem .',
  'Turnover in health care is a serious concern , as it contributes to the global nursing shortage and is associated with declines in quality of care , patient safety and patient outcomes .',
  'Insecurity in medical education : a preventable problem ?',
  'Although nurse turnover is a serious problem , the fact that each nurse has different work-related needs/values , and leaves their job for different reasons makes it difficult for organisations to develop effective countermeasures against it .',
  'There is a serious and growing shortage of nurses in the United States , and the high rate of student attrition from nursing programs has further added to this problem .',
  '[ Congress of the Swiss Nursing Association in Montreux : if interdisciplinary cooperation is not only a slogan but a serious concern , it demands an honest effort from everyone involved ] .',
  'There is a dire need of adopting a systematic approach to faculty development to enhance quality education to meet health challenges for 21st Century .',
  'Despite compelling evidence that there was a serious problem with the management of critically ill patients in the ward environment , there is little evidence to support outreach as a concept or as a role for nurse consultants .',
  'The use of group testing that predicts success in understanding and using the nursing process suggests a tempting solution to a vexing problem : selecting those students from an applicant pool who have the potential to successfully complete a nursing program .'],
 'inactivity': ['Information received subconsciously can influence exercise performance; however, it remains unclear whether subliminal or supraliminal reward is more effective in improving standing balance ability when priming stimuli are subconsciously delivered.',
  'Physical activity confers numerous health benefits, yet few adults meet recommended physical activity guidelines.',
  'Physical inactivity is the fourth leading risk factor for mortality worldwide and a leading risk factor for type 2 diabetes and cardiovascular disease.',
  'Sedentary behaviour in children is related to different health consequences such as overweight and cardio-metabolic diseases that can track into adulthood',
  'Changes in mood following exercise are well documented ; however , one particular limitation of research examining mood changes associated with exercise is that studies have not controlled for a possible expectancy effect .',
  'A continuing problem with recruiting participants for a project involving exercise is that the volunteer population tends to be healthy and interested in physical activity .',
  'The small gains in aerobic power would seem to be of little practical significance for the subjects , and a major drawback of any home exercise program is the lack of motivation to continue .',
  'A key drawback of exercise testing as a measurement of drug effect is the fact that exercise changes produced by drug intervention do not correlate well with changes in the mortality rate .',
  'An increase in the physical activity of individuals has many health benefits , but a drawback of an increase in physical activity is the risk of related injuries .',
  'While physical inactivity and sedentary behavior is a serious health concern , in children and adolescents , regular physical activity is associated with improved subjective and objective sleep and a broad variety of psychological health outcomes .',
  'In particular , a temporary exacerbation of symptoms after an exercise intervention could pose a serious problem concerning patient adherence to treatment .',
  'The research into physical activity level of the elderly is quite crucial as the low level of such activity may lead to disability and that , in turn , generates the need of additional care which constitutes a serious social problem .',
  'Insufficient activity is a serious health concern among university students .',
  "Sedentary life has been recognized as a serious problem in today 's Iranian society .",
  'The special part among the risk factors plays the low physical activity , which , due to rapid development of civilization , makes a serious problem concerning mainly the well-developed countries .',
  'Lack of physical activity is a severe health concern in the United States with fewer than half of all Americans meeting the recommended weekly physical activity guidelines .',
  'This study confirms the growing body of research quantifying physical inactivity as a serious and expensive public health problem .',
  'The intention-behavior gap has proven to be a vexing problem for theorists and practitioners interested in physical activity .',
  'Physical inactivity among children is a serious public health problem .',
  'Physical inactivity during childhood and adolescence is a serious health concern .',
  'Sedentarism is a serious health concern in industrialized countries throughout the world .',
  'Physical inactivity is a serious public health concern in adolescents from low- and middle-income countries ( LMICs ) .',
  'Sedentary lifestyle and its consequences are becoming a serious problem not only among the elderly but also relate to children .',
  'Physical inactivity was considered a serious public health concern by 55 % of the respondents ; similar to unhealthy diets ( 58 % ) and tobacco use ( 57 % ) .',
  'Physical inactivity has reached epidemic levels in developed countries and is being recognized as a serious public health problem .',
  'Low physical activity is a serious health problem in developed and developing countries .',
  'Lack of physical activity among American adults is a serious public health concern .',
  'A physical activity transition to declining activity levels , even among children , now poses a serious public health concern because of its contribution to a rising prevalence of noncommunicable diseases .',
  'On the other hand , sedentary behavior has reached alarming levels among the general population , which qualifies it as a serious health problem of endemic proportions .',
  'The combination of the health risks associated with physical inactivity and obesity presents a serious health concern in this population .'],
 'activity': ['Information received subconsciously can influence exercise performance; however, it remains unclear whether subliminal or supraliminal reward is more effective in improving standing balance ability when priming stimuli are subconsciously delivered.',
  'Physical activity confers numerous health benefits, yet few adults meet recommended physical activity guidelines.',
  'Physical inactivity is the fourth leading risk factor for mortality worldwide and a leading risk factor for type 2 diabetes and cardiovascular disease.',
  'Sedentary behaviour in children is related to different health consequences such as overweight and cardio-metabolic diseases that can track into adulthood',
  'Changes in mood following exercise are well documented ; however , one particular limitation of research examining mood changes associated with exercise is that studies have not controlled for a possible expectancy effect .',
  'A continuing problem with recruiting participants for a project involving exercise is that the volunteer population tends to be healthy and interested in physical activity .',
  'The small gains in aerobic power would seem to be of little practical significance for the subjects , and a major drawback of any home exercise program is the lack of motivation to continue .',
  'A key drawback of exercise testing as a measurement of drug effect is the fact that exercise changes produced by drug intervention do not correlate well with changes in the mortality rate .',
  'An increase in the physical activity of individuals has many health benefits , but a drawback of an increase in physical activity is the risk of related injuries .',
  'While physical inactivity and sedentary behavior is a serious health concern , in children and adolescents , regular physical activity is associated with improved subjective and objective sleep and a broad variety of psychological health outcomes .',
  'In particular , a temporary exacerbation of symptoms after an exercise intervention could pose a serious problem concerning patient adherence to treatment .',
  'The research into physical activity level of the elderly is quite crucial as the low level of such activity may lead to disability and that , in turn , generates the need of additional care which constitutes a serious social problem .',
  'Insufficient activity is a serious health concern among university students .',
  "Sedentary life has been recognized as a serious problem in today 's Iranian society .",
  'The special part among the risk factors plays the low physical activity , which , due to rapid development of civilization , makes a serious problem concerning mainly the well-developed countries .',
  'Lack of physical activity is a severe health concern in the United States with fewer than half of all Americans meeting the recommended weekly physical activity guidelines .',
  'This study confirms the growing body of research quantifying physical inactivity as a serious and expensive public health problem .',
  'The intention-behavior gap has proven to be a vexing problem for theorists and practitioners interested in physical activity .',
  'Physical inactivity among children is a serious public health problem .',
  'Physical inactivity during childhood and adolescence is a serious health concern .',
  'Sedentarism is a serious health concern in industrialized countries throughout the world .',
  'Physical inactivity is a serious public health concern in adolescents from low- and middle-income countries ( LMICs ) .',
  'Sedentary lifestyle and its consequences are becoming a serious problem not only among the elderly but also relate to children .',
  'Physical inactivity was considered a serious public health concern by 55 % of the respondents ; similar to unhealthy diets ( 58 % ) and tobacco use ( 57 % ) .',
  'Physical inactivity has reached epidemic levels in developed countries and is being recognized as a serious public health problem .',
  'Low physical activity is a serious health problem in developed and developing countries .',
  'Lack of physical activity among American adults is a serious public health concern .',
  'A physical activity transition to declining activity levels , even among children , now poses a serious public health concern because of its contribution to a rising prevalence of noncommunicable diseases .',
  'On the other hand , sedentary behavior has reached alarming levels among the general population , which qualifies it as a serious health problem of endemic proportions .',
  'The combination of the health risks associated with physical inactivity and obesity presents a serious health concern in this population .'],
 'exercise': ['Information received subconsciously can influence exercise performance; however, it remains unclear whether subliminal or supraliminal reward is more effective in improving standing balance ability when priming stimuli are subconsciously delivered.',
  'Physical activity confers numerous health benefits, yet few adults meet recommended physical activity guidelines.',
  'Physical inactivity is the fourth leading risk factor for mortality worldwide and a leading risk factor for type 2 diabetes and cardiovascular disease.',
  'Sedentary behaviour in children is related to different health consequences such as overweight and cardio-metabolic diseases that can track into adulthood',
  'Changes in mood following exercise are well documented ; however , one particular limitation of research examining mood changes associated with exercise is that studies have not controlled for a possible expectancy effect .',
  'A continuing problem with recruiting participants for a project involving exercise is that the volunteer population tends to be healthy and interested in physical activity .',
  'The small gains in aerobic power would seem to be of little practical significance for the subjects , and a major drawback of any home exercise program is the lack of motivation to continue .',
  'A key drawback of exercise testing as a measurement of drug effect is the fact that exercise changes produced by drug intervention do not correlate well with changes in the mortality rate .',
  'An increase in the physical activity of individuals has many health benefits , but a drawback of an increase in physical activity is the risk of related injuries .',
  'While physical inactivity and sedentary behavior is a serious health concern , in children and adolescents , regular physical activity is associated with improved subjective and objective sleep and a broad variety of psychological health outcomes .',
  'In particular , a temporary exacerbation of symptoms after an exercise intervention could pose a serious problem concerning patient adherence to treatment .',
  'The research into physical activity level of the elderly is quite crucial as the low level of such activity may lead to disability and that , in turn , generates the need of additional care which constitutes a serious social problem .',
  'Insufficient activity is a serious health concern among university students .',
  "Sedentary life has been recognized as a serious problem in today 's Iranian society .",
  'The special part among the risk factors plays the low physical activity , which , due to rapid development of civilization , makes a serious problem concerning mainly the well-developed countries .',
  'Lack of physical activity is a severe health concern in the United States with fewer than half of all Americans meeting the recommended weekly physical activity guidelines .',
  'This study confirms the growing body of research quantifying physical inactivity as a serious and expensive public health problem .',
  'The intention-behavior gap has proven to be a vexing problem for theorists and practitioners interested in physical activity .',
  'Physical inactivity among children is a serious public health problem .',
  'Physical inactivity during childhood and adolescence is a serious health concern .',
  'Sedentarism is a serious health concern in industrialized countries throughout the world .',
  'Physical inactivity is a serious public health concern in adolescents from low- and middle-income countries ( LMICs ) .',
  'Sedentary lifestyle and its consequences are becoming a serious problem not only among the elderly but also relate to children .',
  'Physical inactivity was considered a serious public health concern by 55 % of the respondents ; similar to unhealthy diets ( 58 % ) and tobacco use ( 57 % ) .',
  'Physical inactivity has reached epidemic levels in developed countries and is being recognized as a serious public health problem .',
  'Low physical activity is a serious health problem in developed and developing countries .',
  'Lack of physical activity among American adults is a serious public health concern .',
  'A physical activity transition to declining activity levels , even among children , now poses a serious public health concern because of its contribution to a rising prevalence of noncommunicable diseases .',
  'On the other hand , sedentary behavior has reached alarming levels among the general population , which qualifies it as a serious health problem of endemic proportions .',
  'The combination of the health risks associated with physical inactivity and obesity presents a serious health concern in this population .'],
 'sedentary': ['Information received subconsciously can influence exercise performance; however, it remains unclear whether subliminal or supraliminal reward is more effective in improving standing balance ability when priming stimuli are subconsciously delivered.',
  'Physical activity confers numerous health benefits, yet few adults meet recommended physical activity guidelines.',
  'Physical inactivity is the fourth leading risk factor for mortality worldwide and a leading risk factor for type 2 diabetes and cardiovascular disease.',
  'Sedentary behaviour in children is related to different health consequences such as overweight and cardio-metabolic diseases that can track into adulthood',
  'Changes in mood following exercise are well documented ; however , one particular limitation of research examining mood changes associated with exercise is that studies have not controlled for a possible expectancy effect .',
  'A continuing problem with recruiting participants for a project involving exercise is that the volunteer population tends to be healthy and interested in physical activity .',
  'The small gains in aerobic power would seem to be of little practical significance for the subjects , and a major drawback of any home exercise program is the lack of motivation to continue .',
  'A key drawback of exercise testing as a measurement of drug effect is the fact that exercise changes produced by drug intervention do not correlate well with changes in the mortality rate .',
  'An increase in the physical activity of individuals has many health benefits , but a drawback of an increase in physical activity is the risk of related injuries .',
  'While physical inactivity and sedentary behavior is a serious health concern , in children and adolescents , regular physical activity is associated with improved subjective and objective sleep and a broad variety of psychological health outcomes .',
  'In particular , a temporary exacerbation of symptoms after an exercise intervention could pose a serious problem concerning patient adherence to treatment .',
  'The research into physical activity level of the elderly is quite crucial as the low level of such activity may lead to disability and that , in turn , generates the need of additional care which constitutes a serious social problem .',
  'Insufficient activity is a serious health concern among university students .',
  "Sedentary life has been recognized as a serious problem in today 's Iranian society .",
  'The special part among the risk factors plays the low physical activity , which , due to rapid development of civilization , makes a serious problem concerning mainly the well-developed countries .',
  'Lack of physical activity is a severe health concern in the United States with fewer than half of all Americans meeting the recommended weekly physical activity guidelines .',
  'This study confirms the growing body of research quantifying physical inactivity as a serious and expensive public health problem .',
  'The intention-behavior gap has proven to be a vexing problem for theorists and practitioners interested in physical activity .',
  'Physical inactivity among children is a serious public health problem .',
  'Physical inactivity during childhood and adolescence is a serious health concern .',
  'Sedentarism is a serious health concern in industrialized countries throughout the world .',
  'Physical inactivity is a serious public health concern in adolescents from low- and middle-income countries ( LMICs ) .',
  'Sedentary lifestyle and its consequences are becoming a serious problem not only among the elderly but also relate to children .',
  'Physical inactivity was considered a serious public health concern by 55 % of the respondents ; similar to unhealthy diets ( 58 % ) and tobacco use ( 57 % ) .',
  'Physical inactivity has reached epidemic levels in developed countries and is being recognized as a serious public health problem .',
  'Low physical activity is a serious health problem in developed and developing countries .',
  'Lack of physical activity among American adults is a serious public health concern .',
  'A physical activity transition to declining activity levels , even among children , now poses a serious public health concern because of its contribution to a rising prevalence of noncommunicable diseases .',
  'On the other hand , sedentary behavior has reached alarming levels among the general population , which qualifies it as a serious health problem of endemic proportions .',
  'The combination of the health risks associated with physical inactivity and obesity presents a serious health concern in this population .'],
 'parkinson': ["Pisa syndrome (PS) represents an important source of disability in Parkinson's disease (PD).",
  "Pisa syndrome (PS) or lateral axial dystonia is often seen in patients with Parkinson's disease (PD).",
  "Deficits in motor movement automaticity in Parkinson's disease (PD), especially during multitasking, are early and consistent hallmarks of cognitive function decline, which increases fall risk and reduces quality of life.",
  "Parkinson's disease (PD) is a neurological disorder, progressive in nature",
  "Drug-induced dyskinesias are a major drawback of the dopaminergic therapies currently employed to treat Parkinson 's disease .",
  "Psychosis is quite common in Parkinson 's disease ( approximately 25 % of patients ) and therefore constitutes a serious public health problem .",
  'Freezing of gait ( FoG ) is a debilitating problem in patients with PD .',
  "Freezing in Parkinson 's disease is a severe and disabling problem of unknown aetiology .",
  "Freezing of Gait ( FOG ) can be a serious problem in Parkinson 's disease ( PD ) and is usually refractory to medical treatment .",
  "Anxiety is a severe problem for at least one-third of people living with Parkinson 's disease ( PD ) .",
  "Dementia in Parkinson 's disease ( PD ) is a serious health issue and a major concern for many patients .",
  "Levodopa-induced dyskinesia ( LID ) is a troublesome problem in the treatment of Parkinson 's disease ( PD ) .",
  "Fatigue is a severe problem for many people living with Parkinson 's disease ( PD ) .",
  "Freezing of gait ( FOG ) and postural instability are challenging motor symptoms that present a serious therapeutic dilemma in Parkinson 's disease ."],
 'pd': ["Pisa syndrome (PS) represents an important source of disability in Parkinson's disease (PD).",
  "Pisa syndrome (PS) or lateral axial dystonia is often seen in patients with Parkinson's disease (PD).",
  "Deficits in motor movement automaticity in Parkinson's disease (PD), especially during multitasking, are early and consistent hallmarks of cognitive function decline, which increases fall risk and reduces quality of life.",
  "Parkinson's disease (PD) is a neurological disorder, progressive in nature",
  "Drug-induced dyskinesias are a major drawback of the dopaminergic therapies currently employed to treat Parkinson 's disease .",
  "Psychosis is quite common in Parkinson 's disease ( approximately 25 % of patients ) and therefore constitutes a serious public health problem .",
  'Freezing of gait ( FoG ) is a debilitating problem in patients with PD .',
  "Freezing in Parkinson 's disease is a severe and disabling problem of unknown aetiology .",
  "Freezing of Gait ( FOG ) can be a serious problem in Parkinson 's disease ( PD ) and is usually refractory to medical treatment .",
  "Anxiety is a severe problem for at least one-third of people living with Parkinson 's disease ( PD ) .",
  "Dementia in Parkinson 's disease ( PD ) is a serious health issue and a major concern for many patients .",
  "Levodopa-induced dyskinesia ( LID ) is a troublesome problem in the treatment of Parkinson 's disease ( PD ) .",
  "Fatigue is a severe problem for many people living with Parkinson 's disease ( PD ) .",
  "Freezing of gait ( FOG ) and postural instability are challenging motor symptoms that present a serious therapeutic dilemma in Parkinson 's disease ."],
 'gait': ["Pisa syndrome (PS) represents an important source of disability in Parkinson's disease (PD).",
  "Pisa syndrome (PS) or lateral axial dystonia is often seen in patients with Parkinson's disease (PD).",
  "Deficits in motor movement automaticity in Parkinson's disease (PD), especially during multitasking, are early and consistent hallmarks of cognitive function decline, which increases fall risk and reduces quality of life.",
  "Parkinson's disease (PD) is a neurological disorder, progressive in nature",
  "Drug-induced dyskinesias are a major drawback of the dopaminergic therapies currently employed to treat Parkinson 's disease .",
  "Psychosis is quite common in Parkinson 's disease ( approximately 25 % of patients ) and therefore constitutes a serious public health problem .",
  'Freezing of gait ( FoG ) is a debilitating problem in patients with PD .',
  "Freezing in Parkinson 's disease is a severe and disabling problem of unknown aetiology .",
  "Freezing of Gait ( FOG ) can be a serious problem in Parkinson 's disease ( PD ) and is usually refractory to medical treatment .",
  "Anxiety is a severe problem for at least one-third of people living with Parkinson 's disease ( PD ) .",
  "Dementia in Parkinson 's disease ( PD ) is a serious health issue and a major concern for many patients .",
  "Levodopa-induced dyskinesia ( LID ) is a troublesome problem in the treatment of Parkinson 's disease ( PD ) .",
  "Fatigue is a severe problem for many people living with Parkinson 's disease ( PD ) .",
  "Freezing of gait ( FOG ) and postural instability are challenging motor symptoms that present a serious therapeutic dilemma in Parkinson 's disease ."],
 'muscle': ['Currently, greater background is required about the effectiveness of myofascial release (MFR) on muscle flexibility.',
  'While proteasome inhibitors show promise in the attenuation of muscle degeneration , proteasome inhibition-induced toxicity was a major drawback of this therapeutic strategy .',
  'Delayed-onset muscle soreness ( DOMS ) is a serious problem for people who do not exercise on a regular basis .',
  'The sharp increase of pro-inflammatory cytokine becomes a severe problem in some degenerative diseases .',
  'Although muscle atrophy is a serious problem during spaceflight , little is known about the sequence of molecular events leading to atrophy in response to microgravity .',
  'These results indicate that when delta-amino(14C)levulinate is used to label heme , reutilization is a serious problem in skeletal muscle .',
  'Weakness of proximal muscle that interferes with activities of daily living is a serious problem for patients with steroid myopathy .',
  'Skeletal muscle atrophy is a serious concern for the rehabilitation of patients afflicted by prolonged limb restriction .',
  'Sarcopenia , or age-related muscle loss , is emerging as a serious public health concern .',
  'Muscle atrophy , characterized by decreased cell number and size , is a serious concern for patients afflicted with inflammatory diseases .',
  'The progressive loss of skeletal muscle mass is a serious pathophysiological              problem in the elderly , which warrants detailed biochemical studies into the underlying              mechanism of age-related fiber degeneration .',
  'Atrophy of skeletal muscles is a serious problem in a microgravity environment .',
  'Muscle atrophy poses a serious concern to patients inflicted with inflammatory diseases .',
  'Disuse-induced skeletal muscle atrophy is a serious concern ; however , there is not an effective mouse model to elucidate the molecular mechanisms .',
  'Bone loss induced by microgravity is a serious problem in space flight .',
  'Muscle atrophy is a severe clinical problem involving the loss of muscle mass and strength that frequently accompanies the development of numerous types of cancer , including pancreatic , lung and gastric cancers .',
  'Bone loss is a serious problem in spaceflight ; however , the initial action of microgravity has not been identified .',
  'The loss of muscle mass ( MM ) is a serious problem which has been demonstrated in patients with rheumatoid arthritis .',
  'Sarcopenia , defined as the age-related loss of muscle mass , is a serious health concern .',
  'Insufficient post-traumatic skeletal muscle regeneration with consecutive functional deficiency continues to be a serious problem in orthopedic and trauma surgery .',
  'Rapid bone loss is a serious health problem for astronauts during long lasting missions in space .',
  'Volumetric muscle loss ( VML ) is a severe and debilitating clinical problem .',
  'Sarcopenia is a serious public health problem associated with the loss of muscle mass and function .',
  'Postflight orthostatic intolerance has been identified as a serious biomedical problem associated with long-duration exposure to microgravity in space .',
  'Thus , sarcopenia is a serious clinical problem among older adults .',
  'Osteoporosis caused by exposure to microgravity represents a serious clinical concern , but the mechanisms have yet to be fully elucidated .',
  'Skeletal muscle dysfunction is a serious problem in older adults with CLDs , reducing their quality of life and survival .',
  'Muscle fatigue is a serious problem in patients with motor neuron diseases ( MNDs ) .',
  'Skeletal muscle atrophy is a serious concern for patients afflicted by limb restriction due to surgery ( e.g. , arthrodesis ) , several articular pathologies ( e.g. , arthralgia ) , or simply following cast immobilization .',
  'Muscle atrophy caused by unloading stress is a serious problem in bed rest patients or astronauts .',
  'Muscle atrophy poses a serious concern to patients inflicted with inflammatory diseases .',
  'Muscle atrophy and wasting is a serious problem that occurs in patients with prolonged debilitating illness , burn injury , spinal injury , as well as with space flight .'],
 'atrophy': ['Currently, greater background is required about the effectiveness of myofascial release (MFR) on muscle flexibility.',
  'While proteasome inhibitors show promise in the attenuation of muscle degeneration , proteasome inhibition-induced toxicity was a major drawback of this therapeutic strategy .',
  'Delayed-onset muscle soreness ( DOMS ) is a serious problem for people who do not exercise on a regular basis .',
  'The sharp increase of pro-inflammatory cytokine becomes a severe problem in some degenerative diseases .',
  'Although muscle atrophy is a serious problem during spaceflight , little is known about the sequence of molecular events leading to atrophy in response to microgravity .',
  'These results indicate that when delta-amino(14C)levulinate is used to label heme , reutilization is a serious problem in skeletal muscle .',
  'Weakness of proximal muscle that interferes with activities of daily living is a serious problem for patients with steroid myopathy .',
  'Skeletal muscle atrophy is a serious concern for the rehabilitation of patients afflicted by prolonged limb restriction .',
  'Sarcopenia , or age-related muscle loss , is emerging as a serious public health concern .',
  'Muscle atrophy , characterized by decreased cell number and size , is a serious concern for patients afflicted with inflammatory diseases .',
  'The progressive loss of skeletal muscle mass is a serious pathophysiological              problem in the elderly , which warrants detailed biochemical studies into the underlying              mechanism of age-related fiber degeneration .',
  'Atrophy of skeletal muscles is a serious problem in a microgravity environment .',
  'Muscle atrophy poses a serious concern to patients inflicted with inflammatory diseases .',
  'Disuse-induced skeletal muscle atrophy is a serious concern ; however , there is not an effective mouse model to elucidate the molecular mechanisms .',
  'Bone loss induced by microgravity is a serious problem in space flight .',
  'Muscle atrophy is a severe clinical problem involving the loss of muscle mass and strength that frequently accompanies the development of numerous types of cancer , including pancreatic , lung and gastric cancers .',
  'Bone loss is a serious problem in spaceflight ; however , the initial action of microgravity has not been identified .',
  'The loss of muscle mass ( MM ) is a serious problem which has been demonstrated in patients with rheumatoid arthritis .',
  'Sarcopenia , defined as the age-related loss of muscle mass , is a serious health concern .',
  'Insufficient post-traumatic skeletal muscle regeneration with consecutive functional deficiency continues to be a serious problem in orthopedic and trauma surgery .',
  'Rapid bone loss is a serious health problem for astronauts during long lasting missions in space .',
  'Volumetric muscle loss ( VML ) is a severe and debilitating clinical problem .',
  'Sarcopenia is a serious public health problem associated with the loss of muscle mass and function .',
  'Postflight orthostatic intolerance has been identified as a serious biomedical problem associated with long-duration exposure to microgravity in space .',
  'Thus , sarcopenia is a serious clinical problem among older adults .',
  'Osteoporosis caused by exposure to microgravity represents a serious clinical concern , but the mechanisms have yet to be fully elucidated .',
  'Skeletal muscle dysfunction is a serious problem in older adults with CLDs , reducing their quality of life and survival .',
  'Muscle fatigue is a serious problem in patients with motor neuron diseases ( MNDs ) .',
  'Skeletal muscle atrophy is a serious concern for patients afflicted by limb restriction due to surgery ( e.g. , arthrodesis ) , several articular pathologies ( e.g. , arthralgia ) , or simply following cast immobilization .',
  'Muscle atrophy caused by unloading stress is a serious problem in bed rest patients or astronauts .',
  'Muscle atrophy poses a serious concern to patients inflicted with inflammatory diseases .',
  'Muscle atrophy and wasting is a serious problem that occurs in patients with prolonged debilitating illness , burn injury , spinal injury , as well as with space flight .'],
 'microgravity': ['Currently, greater background is required about the effectiveness of myofascial release (MFR) on muscle flexibility.',
  'While proteasome inhibitors show promise in the attenuation of muscle degeneration , proteasome inhibition-induced toxicity was a major drawback of this therapeutic strategy .',
  'Delayed-onset muscle soreness ( DOMS ) is a serious problem for people who do not exercise on a regular basis .',
  'The sharp increase of pro-inflammatory cytokine becomes a severe problem in some degenerative diseases .',
  'Although muscle atrophy is a serious problem during spaceflight , little is known about the sequence of molecular events leading to atrophy in response to microgravity .',
  'These results indicate that when delta-amino(14C)levulinate is used to label heme , reutilization is a serious problem in skeletal muscle .',
  'Weakness of proximal muscle that interferes with activities of daily living is a serious problem for patients with steroid myopathy .',
  'Skeletal muscle atrophy is a serious concern for the rehabilitation of patients afflicted by prolonged limb restriction .',
  'Sarcopenia , or age-related muscle loss , is emerging as a serious public health concern .',
  'Muscle atrophy , characterized by decreased cell number and size , is a serious concern for patients afflicted with inflammatory diseases .',
  'The progressive loss of skeletal muscle mass is a serious pathophysiological              problem in the elderly , which warrants detailed biochemical studies into the underlying              mechanism of age-related fiber degeneration .',
  'Atrophy of skeletal muscles is a serious problem in a microgravity environment .',
  'Muscle atrophy poses a serious concern to patients inflicted with inflammatory diseases .',
  'Disuse-induced skeletal muscle atrophy is a serious concern ; however , there is not an effective mouse model to elucidate the molecular mechanisms .',
  'Bone loss induced by microgravity is a serious problem in space flight .',
  'Muscle atrophy is a severe clinical problem involving the loss of muscle mass and strength that frequently accompanies the development of numerous types of cancer , including pancreatic , lung and gastric cancers .',
  'Bone loss is a serious problem in spaceflight ; however , the initial action of microgravity has not been identified .',
  'The loss of muscle mass ( MM ) is a serious problem which has been demonstrated in patients with rheumatoid arthritis .',
  'Sarcopenia , defined as the age-related loss of muscle mass , is a serious health concern .',
  'Insufficient post-traumatic skeletal muscle regeneration with consecutive functional deficiency continues to be a serious problem in orthopedic and trauma surgery .',
  'Rapid bone loss is a serious health problem for astronauts during long lasting missions in space .',
  'Volumetric muscle loss ( VML ) is a severe and debilitating clinical problem .',
  'Sarcopenia is a serious public health problem associated with the loss of muscle mass and function .',
  'Postflight orthostatic intolerance has been identified as a serious biomedical problem associated with long-duration exposure to microgravity in space .',
  'Thus , sarcopenia is a serious clinical problem among older adults .',
  'Osteoporosis caused by exposure to microgravity represents a serious clinical concern , but the mechanisms have yet to be fully elucidated .',
  'Skeletal muscle dysfunction is a serious problem in older adults with CLDs , reducing their quality of life and survival .',
  'Muscle fatigue is a serious problem in patients with motor neuron diseases ( MNDs ) .',
  'Skeletal muscle atrophy is a serious concern for patients afflicted by limb restriction due to surgery ( e.g. , arthrodesis ) , several articular pathologies ( e.g. , arthralgia ) , or simply following cast immobilization .',
  'Muscle atrophy caused by unloading stress is a serious problem in bed rest patients or astronauts .',
  'Muscle atrophy poses a serious concern to patients inflicted with inflammatory diseases .',
  'Muscle atrophy and wasting is a serious problem that occurs in patients with prolonged debilitating illness , burn injury , spinal injury , as well as with space flight .'],
 'sarcopenia': ['Currently, greater background is required about the effectiveness of myofascial release (MFR) on muscle flexibility.',
  'While proteasome inhibitors show promise in the attenuation of muscle degeneration , proteasome inhibition-induced toxicity was a major drawback of this therapeutic strategy .',
  'Delayed-onset muscle soreness ( DOMS ) is a serious problem for people who do not exercise on a regular basis .',
  'The sharp increase of pro-inflammatory cytokine becomes a severe problem in some degenerative diseases .',
  'Although muscle atrophy is a serious problem during spaceflight , little is known about the sequence of molecular events leading to atrophy in response to microgravity .',
  'These results indicate that when delta-amino(14C)levulinate is used to label heme , reutilization is a serious problem in skeletal muscle .',
  'Weakness of proximal muscle that interferes with activities of daily living is a serious problem for patients with steroid myopathy .',
  'Skeletal muscle atrophy is a serious concern for the rehabilitation of patients afflicted by prolonged limb restriction .',
  'Sarcopenia , or age-related muscle loss , is emerging as a serious public health concern .',
  'Muscle atrophy , characterized by decreased cell number and size , is a serious concern for patients afflicted with inflammatory diseases .',
  'The progressive loss of skeletal muscle mass is a serious pathophysiological              problem in the elderly , which warrants detailed biochemical studies into the underlying              mechanism of age-related fiber degeneration .',
  'Atrophy of skeletal muscles is a serious problem in a microgravity environment .',
  'Muscle atrophy poses a serious concern to patients inflicted with inflammatory diseases .',
  'Disuse-induced skeletal muscle atrophy is a serious concern ; however , there is not an effective mouse model to elucidate the molecular mechanisms .',
  'Bone loss induced by microgravity is a serious problem in space flight .',
  'Muscle atrophy is a severe clinical problem involving the loss of muscle mass and strength that frequently accompanies the development of numerous types of cancer , including pancreatic , lung and gastric cancers .',
  'Bone loss is a serious problem in spaceflight ; however , the initial action of microgravity has not been identified .',
  'The loss of muscle mass ( MM ) is a serious problem which has been demonstrated in patients with rheumatoid arthritis .',
  'Sarcopenia , defined as the age-related loss of muscle mass , is a serious health concern .',
  'Insufficient post-traumatic skeletal muscle regeneration with consecutive functional deficiency continues to be a serious problem in orthopedic and trauma surgery .',
  'Rapid bone loss is a serious health problem for astronauts during long lasting missions in space .',
  'Volumetric muscle loss ( VML ) is a severe and debilitating clinical problem .',
  'Sarcopenia is a serious public health problem associated with the loss of muscle mass and function .',
  'Postflight orthostatic intolerance has been identified as a serious biomedical problem associated with long-duration exposure to microgravity in space .',
  'Thus , sarcopenia is a serious clinical problem among older adults .',
  'Osteoporosis caused by exposure to microgravity represents a serious clinical concern , but the mechanisms have yet to be fully elucidated .',
  'Skeletal muscle dysfunction is a serious problem in older adults with CLDs , reducing their quality of life and survival .',
  'Muscle fatigue is a serious problem in patients with motor neuron diseases ( MNDs ) .',
  'Skeletal muscle atrophy is a serious concern for patients afflicted by limb restriction due to surgery ( e.g. , arthrodesis ) , several articular pathologies ( e.g. , arthralgia ) , or simply following cast immobilization .',
  'Muscle atrophy caused by unloading stress is a serious problem in bed rest patients or astronauts .',
  'Muscle atrophy poses a serious concern to patients inflicted with inflammatory diseases .',
  'Muscle atrophy and wasting is a serious problem that occurs in patients with prolonged debilitating illness , burn injury , spinal injury , as well as with space flight .'],
 'hypothermia': ['A moderate proportion of sedated patients who undergo procedures in the cardiac catheterization laboratory with only passive warming become hypothermic.',
  'Studies have shown an increase in mortality and morbidity during heatwaves, especially among the elderly.',
  'The problem with using liquid nitrogen alone is that it causes the formation of a nitrogen gas barrier next to the tissue , which acts as an insulator and inhibits the cooling of the tissues .',
  'One problem with raising the ambient temperature of a vivarium is that personnel wearing protective equipment will be subject to considerable heat stress .',
  'Risk factors for hypothermia in patients under general anesthesia : Is there a drawback of laminar airflow operating rooms ? A prospective cohort study .',
  'A serious and common problem is hypothermia , which can be caused or exacerbated by interventions used in resuscitation , surgery , and postoperative care .',
  'Environmental temperature remarkably impacts on metabolic homeostasis , raising a serious concern about the optimum housing temperature for translational studies .',
  'Accidental hypothermia represents a serious problem in multiple trauma patients due to its frequency and negative pathophysiological effects .',
  'Heat stroke is a serious health concern globally , which is associated with high mortality .',
  'The rebound effect poses a serious concern , suggesting that after the purging period , fresh gas flows of 10 l/minute should be maintained for the duration of anaesthesia care of the malignant hyperthermia susceptible patient .',
  'Hypothermia in near-drowning victims is a serious problem that impacts clinical decision-making .',
  'Trichinosis is a serious but understudied medical problem in the Arctic .',
  'Heat stress can be a serious problem in aircraft flown at low altitudes in warm-to-hot environments .',
  'During torpor , metabolic rate is downregulated to fractions of resting metabolic rate and often associated with a severe drop in body temperature that challenges mammalian physiology .',
  'Sensitivity to cold ( hiesho ) is a serious health problem in Japan , yet it is minimally understood within Western cultures .',
  'Maintaining normothermia in neonates undergoing major operations remains a serious problem which may complicate the perioperative period .',
  'Exposure to cold temperature is a serious but often neglected problem in prehospital care .',
  'Thermal injury ( TI ) with septic complications continues to be a serious clinical problem .',
  'Increased room temperature , a serious problem when working with amalgam , was the most common complaint from the dental personnel reflecting the observation that ventilation in most clinics was far from being satisfactory .',
  'Early diagnosis and treatment for thermal injury with septic complications continue to be a serious clinical problem .',
  'Frostbite , the severest form of cold injury is a serious medical problem for our Armed Forces operating in the snow bound areas at high altitude .',
  'Hypothermia ( less than 35 C ) associated with massive transfusions is a serious clinical problem .',
  'Cold hypersensitivity is a serious clinical problem , affecting a broad subset of patients and causing significant decreases in quality of life .',
  'Environmental heat illness and injuries are a serious concern for the Army and Marines .',
  'Cold intolerance is a serious long-term problem after injury to the ulnar and median nerves , and its pathophysiology is unclear .',
  'Hypothermia of less than 35 degrees C , which frequently occurs in connection with massive blood transfusion , is a serious problem in many patients , in particular in those with polytrauma .',
  'A third disadvantage , for prolonged hypothermia , might be impairment of the immune response , a serious problem if hypoxia is combined with infection .',
  'Exertional heat illness ( EHI ) risk is a serious concern among athletes , laborers , and warfighters .',
  'Exertional heat illnesses ( heat stroke , heat exhaustion , and heat cramps ) are a serious problem in military operations .'],
 'cold': ['A moderate proportion of sedated patients who undergo procedures in the cardiac catheterization laboratory with only passive warming become hypothermic.',
  'Studies have shown an increase in mortality and morbidity during heatwaves, especially among the elderly.',
  'The problem with using liquid nitrogen alone is that it causes the formation of a nitrogen gas barrier next to the tissue , which acts as an insulator and inhibits the cooling of the tissues .',
  'One problem with raising the ambient temperature of a vivarium is that personnel wearing protective equipment will be subject to considerable heat stress .',
  'Risk factors for hypothermia in patients under general anesthesia : Is there a drawback of laminar airflow operating rooms ? A prospective cohort study .',
  'A serious and common problem is hypothermia , which can be caused or exacerbated by interventions used in resuscitation , surgery , and postoperative care .',
  'Environmental temperature remarkably impacts on metabolic homeostasis , raising a serious concern about the optimum housing temperature for translational studies .',
  'Accidental hypothermia represents a serious problem in multiple trauma patients due to its frequency and negative pathophysiological effects .',
  'Heat stroke is a serious health concern globally , which is associated with high mortality .',
  'The rebound effect poses a serious concern , suggesting that after the purging period , fresh gas flows of 10 l/minute should be maintained for the duration of anaesthesia care of the malignant hyperthermia susceptible patient .',
  'Hypothermia in near-drowning victims is a serious problem that impacts clinical decision-making .',
  'Trichinosis is a serious but understudied medical problem in the Arctic .',
  'Heat stress can be a serious problem in aircraft flown at low altitudes in warm-to-hot environments .',
  'During torpor , metabolic rate is downregulated to fractions of resting metabolic rate and often associated with a severe drop in body temperature that challenges mammalian physiology .',
  'Sensitivity to cold ( hiesho ) is a serious health problem in Japan , yet it is minimally understood within Western cultures .',
  'Maintaining normothermia in neonates undergoing major operations remains a serious problem which may complicate the perioperative period .',
  'Exposure to cold temperature is a serious but often neglected problem in prehospital care .',
  'Thermal injury ( TI ) with septic complications continues to be a serious clinical problem .',
  'Increased room temperature , a serious problem when working with amalgam , was the most common complaint from the dental personnel reflecting the observation that ventilation in most clinics was far from being satisfactory .',
  'Early diagnosis and treatment for thermal injury with septic complications continue to be a serious clinical problem .',
  'Frostbite , the severest form of cold injury is a serious medical problem for our Armed Forces operating in the snow bound areas at high altitude .',
  'Hypothermia ( less than 35 C ) associated with massive transfusions is a serious clinical problem .',
  'Cold hypersensitivity is a serious clinical problem , affecting a broad subset of patients and causing significant decreases in quality of life .',
  'Environmental heat illness and injuries are a serious concern for the Army and Marines .',
  'Cold intolerance is a serious long-term problem after injury to the ulnar and median nerves , and its pathophysiology is unclear .',
  'Hypothermia of less than 35 degrees C , which frequently occurs in connection with massive blood transfusion , is a serious problem in many patients , in particular in those with polytrauma .',
  'A third disadvantage , for prolonged hypothermia , might be impairment of the immune response , a serious problem if hypoxia is combined with infection .',
  'Exertional heat illness ( EHI ) risk is a serious concern among athletes , laborers , and warfighters .',
  'Exertional heat illnesses ( heat stroke , heat exhaustion , and heat cramps ) are a serious problem in military operations .'],
 'temperature': ['A moderate proportion of sedated patients who undergo procedures in the cardiac catheterization laboratory with only passive warming become hypothermic.',
  'Studies have shown an increase in mortality and morbidity during heatwaves, especially among the elderly.',
  'The problem with using liquid nitrogen alone is that it causes the formation of a nitrogen gas barrier next to the tissue , which acts as an insulator and inhibits the cooling of the tissues .',
  'One problem with raising the ambient temperature of a vivarium is that personnel wearing protective equipment will be subject to considerable heat stress .',
  'Risk factors for hypothermia in patients under general anesthesia : Is there a drawback of laminar airflow operating rooms ? A prospective cohort study .',
  'A serious and common problem is hypothermia , which can be caused or exacerbated by interventions used in resuscitation , surgery , and postoperative care .',
  'Environmental temperature remarkably impacts on metabolic homeostasis , raising a serious concern about the optimum housing temperature for translational studies .',
  'Accidental hypothermia represents a serious problem in multiple trauma patients due to its frequency and negative pathophysiological effects .',
  'Heat stroke is a serious health concern globally , which is associated with high mortality .',
  'The rebound effect poses a serious concern , suggesting that after the purging period , fresh gas flows of 10 l/minute should be maintained for the duration of anaesthesia care of the malignant hyperthermia susceptible patient .',
  'Hypothermia in near-drowning victims is a serious problem that impacts clinical decision-making .',
  'Trichinosis is a serious but understudied medical problem in the Arctic .',
  'Heat stress can be a serious problem in aircraft flown at low altitudes in warm-to-hot environments .',
  'During torpor , metabolic rate is downregulated to fractions of resting metabolic rate and often associated with a severe drop in body temperature that challenges mammalian physiology .',
  'Sensitivity to cold ( hiesho ) is a serious health problem in Japan , yet it is minimally understood within Western cultures .',
  'Maintaining normothermia in neonates undergoing major operations remains a serious problem which may complicate the perioperative period .',
  'Exposure to cold temperature is a serious but often neglected problem in prehospital care .',
  'Thermal injury ( TI ) with septic complications continues to be a serious clinical problem .',
  'Increased room temperature , a serious problem when working with amalgam , was the most common complaint from the dental personnel reflecting the observation that ventilation in most clinics was far from being satisfactory .',
  'Early diagnosis and treatment for thermal injury with septic complications continue to be a serious clinical problem .',
  'Frostbite , the severest form of cold injury is a serious medical problem for our Armed Forces operating in the snow bound areas at high altitude .',
  'Hypothermia ( less than 35 C ) associated with massive transfusions is a serious clinical problem .',
  'Cold hypersensitivity is a serious clinical problem , affecting a broad subset of patients and causing significant decreases in quality of life .',
  'Environmental heat illness and injuries are a serious concern for the Army and Marines .',
  'Cold intolerance is a serious long-term problem after injury to the ulnar and median nerves , and its pathophysiology is unclear .',
  'Hypothermia of less than 35 degrees C , which frequently occurs in connection with massive blood transfusion , is a serious problem in many patients , in particular in those with polytrauma .',
  'A third disadvantage , for prolonged hypothermia , might be impairment of the immune response , a serious problem if hypoxia is combined with infection .',
  'Exertional heat illness ( EHI ) risk is a serious concern among athletes , laborers , and warfighters .',
  'Exertional heat illnesses ( heat stroke , heat exhaustion , and heat cramps ) are a serious problem in military operations .'],
 'bone': ['Accuracy of meniscal sizing is an important issue before allograft transplantation.',
  '30% of myeloma patients suffer from vertebral compression fractures (VCF).',
  'The skeleton is one of the frequent site of metastases in advanced cancer',
  'A major problem with CIBP in humans is that it increases on weight-bearing and/or movement of a tumor-bearing bone limiting the activity and functional status of the patient .',
  'The main problem with this method is that the time until full recovery may be up to a year , partly because of the time needed for the new formed bone to consolidate and become strong enough for weight bearing .',
  'The major problem encountered when trying to perform a meta-analysis of the available studies for the use of cementoplasty in patients with a VCF is that conservative management has not been standardised .',
  'The main problem with the Ahlbäck classification was that a joint space could often be seen radiographically despite the presence of bone attrition on the preparations .',
  'The basic problem with this method is that the bone graft repair is dependent on the vascular carrier ; the bone needs to be revascularized and regenerate .',
  'A major problem with osteoporosis in men is that it continues to be unrecognized , and the majority of men with fragility fractures due to osteoporosis are not being treated .',
  'We speculated that the underlying problem with current bone grafting techniques is that they promote bone regeneration through direct osteogenesis .',
  'However , the major problem associated with most currently clinical available artificial bone substitutes ( scaffolds ) is that they mainly possess filling function but lack of osteo-induction abilities .',
  'A less appreciated problem with caffeine is that it may increase the risk of osteoporosis and hip fracture .',
  'The problem with imaging bone metastases is that capromab detects an antigenic site on the intracellular portion of PSMA-a site not accessible to circulating antibodies .',
  'Macroscopic analysis showed a distinct drawback of posterior nail positioning , with diminished options for the placement of the locking screws and thereby a risk of damaging the anterior and posterior neuro-vascular bundles by distal medio-lateral locking screws .',
  'A potential drawback of gamma-secretase inhibitors was their ability to enhance osteoclastic maturation of normal circulating preosteoclasts induced by RANKL + M-CSF .',
  'A potential drawback of GH replacement therapy in GH deficient ( GHD ) patients is the initial decrease in bone mass .',
  "A drawback of current robot systems is that they autonomously machine the bone , in that way ignoring the surgeon 's experience and introducing a safety risk .",
  'Implant separation from bone tissue , resulting in the necessity for revision surgery , is a serious drawback of cementless total joint replacement .',
  'A significant drawback of atlantoaxial transarticular screw fixation is a potential risk of vertebral artery injury , especially with a high-riding type .',
  'The formation of gaps in the polar region of acetabular cups is seen as a drawback of press-fit fixation of non-cemented acetabular cups .',
  'A major drawback of standard DXA is that the bone mineral density ( BMD ) data can not be used with certainty to predict who will sustain a vertebral fracture .',
  'A drawback of the study was that the plywood plates increased the contact area and therefore reduced the mean and maximum pressures in the claws they were attached',
  'A major drawback of conventional fixator system is the penetration of fixator pins into the medullary canal .',
  'However , a drawback of bone healing research is the lack of stable and adaptable fixation devices for small animals .',
  'Osteoporosis is a serious health problem in the U.S. today resulting in premature mortality , deformity , pain , loss of function , and disability .',
  'Large-area or critical-sized bone defects pose a serious challenge in orthopedic surgery , as all current treatment options present with shortcomings .',
  'Osteoporosis is a serious clinical problem that often follows the accelerated bone loss that occurs after the estrogen withdrawal of menopause .',
  'Therefore , IL-18 may be useful for suppression of osteolytic bone metastasis which is a serious problem in patients of advanced breast cancers .',
  'The most serious complication of osteoporosis is bone fractures , especially fractures of the proximal femur , which are a serious medical and social problem .',
  'The authors concluded that loosening of the prosthetic components in bone is not a serious problem , but other problems remain .',
  'Especially , pain secondary to bone metastases is a serious problem in many patients with metastatic cancer .',
  'Osteoporosis in men is a disease that is increasing in incidence , and with an increasing elderly population it poses a serious health problem .',
  "A serious problem arose in the form of migration of a meniscal screw that had been inserted in accordance with the manufacturer 's instructions .",
  'Aseptic loosening of artificial knee joints induced by wear particles from a tibial polyethylene ( PE ) insert is a serious problem limiting their longevity .',
  'Because nonunion following bone grafting for arthrodesis of the spine is a serious clinical problem , we have studied the amount of motion seen at the interlumbar and lumbosacral joints in sheep to ascertain how much motion is compatible with union and how much is associated with nonunion .',
  'Diabetic osteoporosis is a severe public health concern in the world .',
  'Osteoporosis is a serious health problem affecting more than 200 million elderly people worldwide .',
  'Syndromes of bone disease and deformities consequent to disorders of nutrition , bone and mineral metabolism constitute a serious national health problem .',
  'Osteoporosis is a serious global health problem for the future , that is why improving diagnostic methods and prevention of this disease could be helpful .',
  'Aseptic loosening of prosthetic implants remains a serious orthopaedic problem and the greatest limitation to total joint arthroplasty .',
  'Osteoporosis has rapidly evolved into a severe health threat to Americans and a major public health problem .',
  'Fracture of the implant abutment screw can be a serious problem , as the fragment remaining inside the implant may prevent the implant from functioning efficiently as an anchor .',
  'Bone metastases are a severe problem in oncology , since they usually are associated with pain .',
  'Fragility fractures represent a serious social and economic problem ; the diagnosis of osteoporosis is an unachieved target by orthopaedic surgeons , despite the chance to detect it in many clinical assets and the availability of effective treatment tools .',
  'Osteoporosis is a serious worldwide public health concern .',
  'However , glenoid loosening remained a serious problem , and transacromial approaches were complicated by failure of acromial fixation .',
  'The long-term loosening of artificial hip joints remains a serious clinical problem .',
  'The prevention of fragility fractures in patients with sarcoidosis is a serious concern and the potential risk of hypercalcemia limits vitamin D and calcium supplementation .',
  'Recently , the incidence of osteoporosis and its related fracture are increasing as the aging of population has been progressing in most developed countries , becoming a serious medical and social problem .',
  'Estrogen deficiency osteoporosis has become a serious problem in elderly women .',
  'Osteoporosis , mainly characterised by low bone mineral density ( BMD ) , is a serious public health problem .',
  'Aseptic loosening of orthopaedic implants secondary to wear debris-induced osteolysis is a serious problem .',
  'Diabetic osteoporosis has become a severe public health problem in the aging societies .',
  'It represents a serious postoperative problem for the patient , associated with plate breakage and loosening , bone defect , shortening deformity and infection .',
  'Osteoporosis is a serious public health problem and icariin ( ICA ) is the active component of the Epimedium \xa0 sagittatum , a traditional Chinese medicinal herb .',
  'Osteoporosis is a severe health problem causing bone fragility and consequent fracture .',
  'Dislocation is a serious problem after revision THA with multiple risk factors .',
  'Osteoporosis , a multifaceted bone disorder , is considered as a serious health problem throughout the world and the magnitude of diseased patients is increasing day by day .',
  'The compromised capacity of bone healing in osteoporotic population renders a serious concern of patients and clinicians .',
  'Loosening of the implant after total joint arthroplasty remains a serious problem .',
  'Osteoporosis was a serious health concern that most commonly affected women .',
  'Osteoporosis is a skeletal disease mainly affecting women over 50 years old and it represents a serious public health problem because of the high socioeconomic burden .',
  'However , many studies have reported the issue of loosening pedicle screws after spinal surgery , which is a serious concern .',
  'Bone metastases to the acetabulum and pelvis can be a devastating and debilitating problem .',
  'Post-menopausal osteoporosis has become a serious public health problem with the increase of the geriatric population .',
  'Besides the biomechanical questions bone defects are a severe problem in cases of revision .',
  'Osteoporosis is a serious health problem worldwide .',
  'Bone metastases remain a serious health concern because of limited therapeutic options .',
  'Osteoporosis is a serious health problem for men .',
  'This report shows that ectopic bone formation , a serious problem in orthopedic surgery , can be controlled in an animal model by local application of EHDP ( disodium-ethane-1-hydroxy-1,1-diphosphonate ) .',
  'Metastatic calcification progressed but was never a severe clinical problem .',
  'The diagnosis of primary tumors with inaugural bone metastases is a serious and difficult problem commonly encountered in rheumatology .',
  'A loss of adhesive strength between metal stem and bone cement is clinically found to be a serious problem in total hip arthroplasty and causes many operative revisions .',
  'Large , complex bony defects can be a vexing problem for the reconstructive surgeon , especially when standard donor sites are not available or do not provide sufficient tissue .',
  "Osteoporosis , a debilitating disease caused by an imbalance between the action of osteoblasts and osteoclasts , is becoming an increasing problem in today 's aging population .",
  'Bone loss after THA can be a serious problem in revision surgery because bone deficiencies may limit reconstructive options , increase the difficulty of surgery , and necessitate autogenous or allogenic bone grafting .',
  'Progression of osteoporosis and bone fracture in aging male populations is a serious concern not only as medical aspect but also as administrative issue in the developed nations where aging peoples has been increasing .',
  'Osteoporosis constitutes a serious health problem in old people .',
  'The development of crack patterns is a serious problem affecting the durability of orthopedic implants and the prognosis of patients .',
  'For others it is a worrisome problem since it alters the heterogeneous cement sheath , leading to loosening and final surgical revision , with an incidence up to 20 % .',
  'Pain is a serious and common problem in bone metastases .',
  'As osteoporosis is a serious health problem , a large number of studies focus on elucidating the aetiology of the disease as well as on the identification of novel therapeutic targets for the treatment of osteoporotic patients .',
  'Osteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide , with severe consequences including vertebral fractures that are associated with significant morbidity and mortality .',
  'Even though biological fixation is a reliable fixation method in THA , polyethylene wear and osteolysis remain a serious problem for cementless cup designs with unplugged screw holes and low-quality liners .',
  'Bone loss is a serious clinical problem that is frequently accompanied by chronic inflammation , illustrating that there is a convoluted relationship between inflammation and bone erosion .',
  'Osteoporosis ( OP ) is a serious health problem that contributes to osteoporotic structural damage and bone fragility .',
  'Osteoporosis is a serious health problem among postmenopausal women .',
  'Bone incidents today represent , in terms of frequency and the overall effect on the quality of life of patients with breast cancer , a serious health problem .',
  "Osteoporosis and pathological bone fractures which are its consequences are a serious health problem of today 's world .",
  'Osteoporosis , which has become a serious public health concern , is influenced by diet , especially calcium intake .',
  'Pathological fractures and osteolyses with impending fractures of long bones impose a severe problem in patients with advanced cancer .',
  'Bone metastasis is a serious problem for individuals with prostate cancer , and the effects of the anticancer drug docetaxel ( DTX ) are insufficient .',
  'Osteoporosis is a serious health problem of endemic proportions in the United States .',
  'Osteoporosis is a serious problem , since about 50 % of women over the age of 50 suffer at least one osteoporotic fracture .',
  'In free-text fields , GPs reported most frequently that budgetary restrictions preventing the prescription of appropriate medication represented a severe problem for osteoporosis management .',
  'On the other hand , bone destruction was a serious problem among a minority of " risk " individuals after the age of 40 .',
  'Decreased bone density ( osteoporosis and osteomalacia ) is a serious problem for celiacs .',
  'Vertebral compression fractures represent a serious health care problem .',
  'Bone diseases such as osteoarthritis , osteoporosis , and bone tumor present a severe public health problem .',
  'Since the mid-1980s , postmenopausal osteoporosis ( PMO ) has been considered a serious public health concern because of the associated fractures .',
  'Osteoporosis is a serious medical problem because of its complications , most frequently manifesting itself in spine fractures , fractures of distal sections of the forearm and , in later periods of life , hip fractures .',
  'Osteoporosis is a serious health problem in both Caucasians and Asians .',
  'Osteoporosis had become a serious public health problem among the elderly , bringing about the increase of economic burden all over the world both on social healthcare and families of the patients .',
  'Abutment screw loosening is a serious problem that can result in abutment screw fractures .',
  'Osteoporosis is a serious public health problem , leading to significant mortality not only in aging females but also in males .',
  'Postmenopausal osteoporosis is a serious health problem , and additional treatments are needed .',
  'Bone marrow injury remains a serious concern in traditional cancer treatment .',
  'Osteoporosis , the most common metabolic bone disease , is a devastating problem and an increasingly major public health issue .',
  'As the population rapidly ages , osteoporosis has been a serious problem .',
  'Osteoporosis is a serious health problem that worsens the quality of life and the survival rate of individuals with this disease on account the osteoporotic fractures .',
  'Osteoporosis and related fragility fractures represent a serious and global public health problem .',
  'Low bone mineral density ( BMD ) is a silent disease that can lead to osteoporosis and is a serious health problem worldwide .',
  'The high worldwide prevalence of osteoporosis means it is considered a serious public health concern , possibly leading to physical disability and an increased mortality rate .',
  'Bone metastases represent a devastating clinical problem in the most frequent neoplasies , especially in multiple myeloma , tumours breast , prostate and lung .',
  'Osteoporotic fractures are a debilitating and a frequently fatal health problem for older adults .',
  'Aging-related osteoporosis ( OP ) is considered a serious public health concern .',
  'Loosening is a serious problem in total arthroplasty and early detection of bone loss in the vicinity of an implant would help in its investigation .',
  'Although a free vascularized iliac bone graft has been successfully used for the reconstruction of large bone defects , there is a serious problem of how to repair in one stage patients having a large bone defect with a very wide skin defect .',
  'In the past , osteoporosis was a serious health concern that most commonly affected women in Northern Europe and the United States of America , but was less commonly seen in Asian women .',
  'As a result of population ageing worldwide , osteoporotic fractures are becoming a serious problem in the western world .',
  'The prevalence of osteoporosis amongst patients with primary biliary cirrhosis ( PBC ) is high and may be a serious clinical problem .',
  'Osteoporosis is a serious national and global public health problem , but data on bone health are limited for Asian women living in the U.S. , the majority of whom are Chinese .',
  'Osteoporosis is a serious public health problem that causes at least 1.3 million fractures and costs more than $ 6 billion annually .',
  'However , aseptic loosening , caused to a great extent by adverse biological local reactions , induced by wear products from the articular surfaces , remains a serious problem .',
  'Osteoporosis is a serious health concern affecting millions of Americans , with many patients going undiagnosed and untreated .',
  'Osteoporosis represents a serious health problem worldwide associated with an increased risk of fractures and mortality .',
  'CONTEXT : Low bone mineral density ( BMD ) is a serious public health problem .',
  'Osteoporosis is a serious health problem worldwide and leads to a significant burden on society .',
  'Osteoporosis is a serious health problem for women over 45 years of age .',
  'Bone diseases are a serious problem in modern human life .',
  'Metastatic bone disease is found in 80 - 90 % of patients examined after death and is a serious problem in everyday practice .',
  'Large osseous defect remains a serious clinical problem due to the lack of sufficient blood supply and it has been proposed that this situation can be relieved by accelerating the formation of new vessels in the process of bone defect repair .',
  'Bone loss is a serious health problem .',
  'Early proximal junctional failures above adult deformity constructs are a serious clinical problem ; however , the incidence and nature of early APJFs remain unclear .',
  "By the impact of demographic changes and as the result of the ' incorrect ' lifestyles pursued in developed societies , osteoporosis has become a serious social problem .",
  'Osteoporosis is a serious health problem worldwide .',
  'If the pedicle screw passes though the cortex bone in surgery , it has a risk to damage the spinal cord and vertebral artery , which can be caused to a serious problem such as paralysis .',
  'Revision in ASD patients is a serious problem with a total rate of 11.38 % , and implant failure , pseudarthrosis , adjacent segment degeneration , and PJK are common reasons for revision .',
  '" Osteoporosis and the consequences of compromised bone strength -- particularly vertebral and hip fractures -- are a significant cause of frailty , and increased morbidity and even mortality and hence are a serious and costly public health problem in the elderly population .',
  'Osteoporosis is a serious health problem worldwide that is associated with an increased risk of fractures and mortality .',
  'Vertebral fractures , are a serious clinical problem for elderly osteoporotic patients , have been increasingly recognized and are now common .',
  'For the radiation oncologist in an emergency situation with acute progressive paraplegia distinguishing between benign versus malignant vertebral compression fracture without known malignoma may cause a severe diagnostic problem , when a rapid therapeutic decision is required .',
  'Fracture of the implant abutment can be a serious problem as the fragment remaining inside the implant may prevent the implant from functioning efficiently .',
  'For long-term treatment , the development of osteoporosis is a serious problem .',
  'Osteoporosis is a serious health concern , particularly in aged societies .',
  'Painful fractures of the spine pose a serious clinical problem which gains in importance with the increasing ageing of our population .',
  'Osteoporosis , due to its prevalence worldwide , is a serious health problem .',
  'In this study , these functions of MLT have been investigated in rat bone ( femur ) and in human adipose MSC ( hMSC ) during chronic exposure to low-grade cadmium ( Cd ) toxicity , a serious public health concern .',
  'Osteoporosis is a serious health problem characterized by decreased bone mineral density and deterioration of bone microarchitecture .',
  'Osteoporosis is a serious national public health problem , and is expected to increase significantly over the next few decades , especially in women .',
  'Osteoporosis represents a serious health problem worldwide and is associated with an increased risk for fractures and mortality .',
  'Osteoporosis is a serious public health problem characterized by low bone density and deterioration of the bone microarchitecture .',
  'Bone graft resorption with prominence of the metalwork is a serious concern , whereas the relative contribution of the dynamic sling effect of a Latarjet procedure is still controversial .',
  'Regarding the vibration magnitude and exposure time , segmental vibration seems not to be a serious problem in orthopaedists .',
  'Subsequent loss of augmentation properties during follow-up is a serious problem of kyphoplasty using injectable CPC in osteoporotic vertebral compression fractures .',
  'Ensuring the diagnosis , prevention , and treatment of long-term toxicities and comorbid conditions like osteoporosis in breast carcinoma survivors is a serious concern and is of increasing importance .',
  'The reconstruction of critically sized bone defects remains a serious clinical problem because of poor angiogenesis within tissue-engineered scaffolds during repair , which gives rise to a lack of sufficient blood supply and causes necrosis of the new tissues .',
  'It is a serious health problem showing the predisposed person with increased bone fracture risk .',
  'Osteoporosis is a serious health problem that diminishes quality of life and levies a financial burden on those who fear and experience bone fractures .',
  'Sometimes osteoporosis can be diagnosed with fractures or with a serious health problem , and most women are probably unaware of the risk factors which can be changed by prevention .',
  'Many studies have addressed the problem of loosening pedicle screws in spinal surgery , which is a serious concern .',
  'It is possible to avoid developing a serious osteoporosis and having bone fracture if we realise the problem at the proper time and take the risk factors into consideration .',
  'Osteoporosis is a serious public health problem , and dietary interventions may potentially be helpful in preventing this disorder .',
  'The repair of large bone defects often associated with bone tumor resections is not observed , and nonunion or delayed union of bone is a serious problem for fracture treatment .',
  'Osteoporosis is a serious problem worldwide ; it is characterized by bone fractures in response to relatively mild trauma .',
  "Bone metastases are a serious problem in patients with advanced cancer disease and their presence usually signifies serious morbidity prior to the patient 's death .",
  'The metastasis of breast cancer to the skeleton is a serious clinical problem resulting in hypercalcemia , bone fragility and insurmountable pain .',
  'Osteoporosis is a serious public health concern .',
  'Osteoporosis has increased and developed into a serious public health concern worldwide .',
  'It is essential to evaluate osteoporosis risk factors , mainly the modifiable , like the lifestyle , in Mexican women in order to prevent it , since it is a serious public health problem .',
  'Osteoporosis is a serious health problem in the population , mainly for postmenopausal women .',
  'Bone mineral content ( BMC ) and/or bone mineral density ( BMD , i.e. BMC scaled by bone size ) are major determinants for osteoporosis , which is a serious health problem .',
  'Metastatic bone disease is a serious clinical problem in patients with advanced cancer .',
  'Because of its high prevalence worldwide , osteoporosis is considered a serious public health concern .',
  'Osteoporosis is a serious public health concern .',
  'Osteoporotic vertebral compression fractures ( OVCFs ) have gradually evolved into a serious health care problem globally .',
  'Periprosthetic bone loss following total hip arthroplasty ( THA ) is a serious concern leading to the premature failure of prosthetic implant .',
  'However , resorption of the bone graft with metal screw protrusion is a serious concern , whereas the relative contribution of the dynamic sling effect of the Latarjet procedure remains controversial .',
  'Scaphoid non-union , particularly following internal fixation , is a vexing problem .',
  'Osteoporosis is a serious public health concern worldwide , and community-based public health programs that increase osteoporosis preventive behaviors are ideal to combat this major public health issue .',
  'Mouse models are invaluable tools for mechanistic and efficacy studies of the healing process of large bone defects resulting in atrophic nonunions , a severe medical problem and a financial health-care-related burden .',
  'Osteoporosis in the elderly is a serious problem that is increasing as the population ages .',
  'Osteoporosis is a serious public health concern worldwide .',
  'Pathologic fracture of the hip due to metastatic lesions in bone is a serious problem .',
  'Osteoporosis has become a serious health problem throughout the world which is associated with an increased risk of bone fractures and mortality among the people of middle to old ages .',
  'Osteoporosis is a serious health problem that has reached epidemic proportions among Canadian women .'],
 'depression': ['Depression is a serious mental health disorder and characterized by sadness, loss of interest in activities, and decreased energy.',
  'Early life adversity (ELA) is not uncommon in major depressive disorder (MDD) patients.',
  'Depression is an extremely common mental health disorder, with prevalence rates rising.',
  'Cognitive behaviour therapy (CBT) and interpersonal psychotherapy (IPT) are the most studied psychotherapies for treatment of depression, but they are rarely directly compared particularly over the longer term.',
  'High prevalence rates of psychiatric morbidity have been documented among adolescents within youth correctional institutions in Nigeria',
  'Depression is a disorder that is highly prevalent nowadays',
  'A major problem with current anti-depressant therapy is that it takes on average 6 - 7 weeks for remission .',
  'The delayed onset of therapeutic outcomes is a major drawback of the current antidepressants .',
  "Treatment-resistant depression is a serious problem with significant costs in terms of health care dollars and patients ' well-being .",
  'Major depressive disorder ( MDD ) is a serious US public health problem for children and adolescents .',
  'Depression is a serious mental health issue and a major concern among middle-aged women , especially during the menopause transition time .',
  'Depression , a mental illness characterized by persistent feeling of sadness and loss of interest , has been a serious health problem worldwide .',
  'The author ascertains that there are several obstacles in the recognition , treatment and prevention of child-depression that causes a serious public health problem .',
  'Undertreatment of depressive symptoms among older persons remains a serious problem .',
  'Nonadherence in adolescents with chronic illness is a serious problem in need of greater recognition and intervention and further research .',
  'Treatment-resistant depression ( TRD ) is a serious problem in adolescents .',
  'Major depression is a serious public health problem and one of the most common psychiatric disorders , and it is estimated that millions of people are affected worldwide .',
  'Depression in older adults is a serious health problem with a poor prognosis .',
  'Major depressive disorder ( MDD ) represents a serious global health concern .',
  'Depression poses a serious economic problem .',
  'Anxiety in adolescence has been a serious problem nowadays . It is seen that anxiety among students cause many harms to their mental and physical health affecting their career .',
  'Nowadays , depression is a serious clinical problem , as the prevalence of its various forms increases and there are growing numbers of patients with severe forms of depression and treatment-refractory depression .',
  'Depression in inner city adolescents represents a serious problem that may be best first detected in a medical setting .',
  'Depression is a serious problem for the oldest-old but a number of correlates are consistently identified in the oldest-old , as well as the two other age groups in the elderly population .',
  'Depression is a serious public health concern .',
  'Depression is a serious public health problem in Pakistan because of the disabilities it causes and the cost burden for the family .',
  'Late-life depression ( LLD ) is a severe public health problem .',
  'Emotional and behavioural are a serious mental health concern among adolescents .',
  'Depression is a common disorder considered to be a serious public health problem although clinicians encounter very different levels of severity and the treatment strategies are tailored according to this variability .',
  'The implications of failure to recognize the possibility of depression among elderly White men suggest a serious public health problem .',
  'Depressive disorder is a severe psychiatric problem all over the world .',
  'Underrecognition and undertreatment of affective disorders ( i.e. , major depressive disorder and bipolar affective disorder ) constitute a serious public health problem in this country .',
  'Depression is a serious problem for women , one that is , in some cases , related to the sociocultural environment .',
  'Depression can be a serious problem for HIV infected .',
  'Although depression is a treatable cause of suffering , disability and death , its identifcation and treatment continue to be a challenge in clinical practice and a severe problem for global public health .',
  'Depression is a serious mental health concern among adolescents .',
  'Considering that persisting depressive symptoms are associated with a range of unfavourable outcomes , the present data point to a serious problem in the treatment of MDD and the urgent need to further optimize antidepressive treatment strategies .',
  'The prevalence of mental depression has increased in recent years , and has become a serious health problem in most countries of the world , including India .',
  'Depression is a serious mental health problem , whose first onset is usually in adolescence .',
  'Depression is a serious mental health problem in older adults .',
  'Late-life depression is a serious health problem that is challenging to manage but generally responds well to pharmacotherapy .',
  'Major depressive disorder ( MDD ) represents a serious health problem estimated to affect 350 million people globally .',
  'It is not known , however , if it is effective in individuals with partially remitted depressive disorder , which is a serious clinical problem in up to 50 - 60 % of treated patients .',
  'Depression is a serious problem for many older adults but is too often undetected by the person , family or providers .',
  'Major depressive disorder ( MDD ) is a serious mental health problem in modern society , which is difficult to identify and diagnose in the early stages .',
  'Depression is a serious health problem , with lifetime prevalence in the western world of 20 - 30 % .',
  'Major depressive disorder is a severe clinical problem across the globe , with a lifetime risk of 10%-30 % for women and 7%-15 % for men .',
  'Major depressive disorder ( MDD ) is a serious health concern worldwide .',
  'Depression in children and adolescents has become a serious public health problem worldwide .',
  'Depression is a serious disorder that affects hundreds of millions of people around the world and causes poor quality of life , problem behaviors , and limitations in activities of daily living .',
  'To examine predictors of parental perception of hyperactivity as a serious problem and its role in determining the use of specialist mental health services .',
  'Depression is a serious mental health problem facing many women with physical disabilities that does not appear to be adequately addressed by health care professionals .',
  'Depressive disorders constitute a serious problem in the United States and around the world .',
  'Underdetection and undertreatment of depression is a serious problem in palliative care .',
  'Depression is a serious public health problem .',
  'The diagnosis and treatment of depression in elderly adults is a serious concern in outpatient settings , where it is well known that practicing physicians often overlook the possibility of depression in adult patients of all ages .',
  'Major depressive disorder ( MDD ) is a serious public problem , affecting 4 - 6 % of adolescents at any one time .',
  'Background Untreated mental illness among adolescents is a serious public health concern .',
  'Depression in adolescents is a serious problem to society because of the high prevalence rate , the high subjective burden of illness and negative ( economic ) consequences .',
  'The results of this study suggest that apathy is a severe problem in KS .',
  'Depressive disorders in people older than 65 years seem to be a serious medical and social problem in many countries .',
  'Major depressive disorder ( MD ) is a debilitating public mental health problem with severe societal and personal costs attached .',
  'Depression among elderly primary care patients is a serious problem with significant morbidity and mortality .',
  'Depression during adolescence is a serious mental health problem .',
  'Depression is a serious public health problem that particularly affects women and elderly people .',
  'Adolescent depression is a severe mental health problem .',
  'Depression is a severe mental disorder that challenges mental health systems worldwide as the success rates of all established treatments are limited .',
  'Most respondents agreed that depression in PLHIV is a serious problem ( 91 % ) and is associated with poorer HIV-related outcomes ( 62%-81 % ) .',
  'Major depression is a serious global health concern ; however , the pathophysiology underlying this condition remains unclear .',
  'Major depression affects more than 5 % of the population and is a serious health and economic problem .',
  'In conclusion , mental health disorders in children and adolescents are a serious problem associated with several potentially modifiable factors .',
  'Major depressive disorder , or depression , becomes a serious public health problem globally .',
  'However , because undertreatment remains a serious problem among depressed elderly , well-designed prescription drug policies should be coupled with interventions to address under-treatment .',
  'This flows from a recognition of depression as a serious and costly problem , with women carrying twice the risk of men .',
  'According to the World Health Organization , the alarming increase in rates of depression globally has become a serious concern .',
  'Depression has become a severe societal problem in China .',
  'Depression among PLWH is a severe problem in China .',
  'Depression is a life-threatening psychiatric disorder and a major public health concern worldwide with an incidence of 5 % and a lifetime prevalence of 15%-20 % .',
  'Depression has recently become a serious problem in society worldwide .',
  'Major depressive disorder ( MDD ) , a debilitating mental illness , could cause functional disabilities and could become a social problem .',
  'The high prevalence of child and adolescent psychiatric disorders in general and of aggressive behaviors in particular presents a serious problem .',
  '( 1 ) Depression is a serious mental health problem particularly in children and adolescents that requires early identification and intervention .',
  'Refractory major depressive disorder ( MDD ) is a serious problem leading to a heavy economic burden .',
  'Unmet need for behavioral health care is a serious problem for crossover youth , or those simultaneously involved with the child welfare and juvenile justice systems .',
  'Depression is a common and impairing disorder which is a serious public health problem .',
  'The study \'s findings support the notion that a serious gap exists between the established efficacy of antidepressant medications and rates of treatment for major depression in the " real world . " Underreporting of depressive symptoms to providers and problems with access to general medical care appear to be 2 major contributors to this problem .',
  "On the patients ' side , sometimes sufferers do not notice the symptoms of depression by themselves , which may also be a serious problem .",
  'Thus , depression in late life is a serious mental health problem .',
  'Depression is a debilitating mental health problem that tends to run a chronic , recurrent course .',
  'Childhood and adolescent mental health problems are a serious and growing concern worldwide .',
  'Major depressive disorder ( MDD ) is a highly prevalent debilitating psychiatric disease and a serious public health problem worldwide .',
  'The prevalence of depression worldwide is increasing from year to year and constitutes a serious medical , economic and social problem .',
  'Even with the best psychosocial and pharmacological treatments for unipolar depression , relapse is a serious problem .',
  'With the older population increasing worldwide , depressive disorder in this cohort is a serious public health problem that contributes to increased healthcare costs and mortality .',
  'We have become concerned about a group of people who have the potential to live largely independently ( or semi-independently ) , to work at meaningful jobs in the community , and to make full use of the same recreational and leisure opportunities as other members of society but who are prevented from doing so because of a life-threatening behavior problem .',
  'Youth depression is a debilitating condition that constitutes a major public health concern .',
  'Major depression is a serious and often persistent problem for 5 to 10 percent of patients in primary care .',
  'Depression is increasingly threatening human health as a serious psychological problem .',
  'An increased incidence of depressive disorders observed in recent years in the Polish and world population is a serious health problem .',
  'Depression in later life is a severe public health problem , associated with higher rates of mortality , suicide , and dementia .',
  'Dissociative behavior is widespread among these youth and may pose a serious mental health concern .',
  'Late-life depression is a serious public health problem and a concern for the primary care physician .',
  'Depression among caregivers of older persons is a serious concern , but it is often overlooked and neglected in developing countries .',
  'Diagnosing depression in the elderly poses a serious problem because of the ageing process and various diseases that influence and mask symptoms of depressed mood .',
  'Behavioral instability in children and adolescents is a vexing problem faced by many clinicians .',
  'Depression is a life-threatening psychiatric disorder and a multifactorial global public health concern .',
  'Older adults with low incomes rarely use mental health care , and untreated depression is a serious problem in this population .',
  'Major depressive disorder ( MDD ) is a serious U.S. public health problem for children and adolescents .',
  'Depression is a serious mental health problem and is common in children and adolescents .'],
 'depressive': ['Depression is a serious mental health disorder and characterized by sadness, loss of interest in activities, and decreased energy.',
  'Early life adversity (ELA) is not uncommon in major depressive disorder (MDD) patients.',
  'Depression is an extremely common mental health disorder, with prevalence rates rising.',
  'Cognitive behaviour therapy (CBT) and interpersonal psychotherapy (IPT) are the most studied psychotherapies for treatment of depression, but they are rarely directly compared particularly over the longer term.',
  'Depression is a disorder that is highly prevalent nowadays',
  'A major problem with current anti-depressant therapy is that it takes on average 6 - 7 weeks for remission .',
  'The delayed onset of therapeutic outcomes is a major drawback of the current antidepressants .',
  "Treatment-resistant depression is a serious problem with significant costs in terms of health care dollars and patients ' well-being .",
  'Major depressive disorder ( MDD ) is a serious US public health problem for children and adolescents .',
  'Depression , a mental illness characterized by persistent feeling of sadness and loss of interest , has been a serious health problem worldwide .',
  'Major depression is a serious public health problem and one of the most common psychiatric disorders , and it is estimated that millions of people are affected worldwide .',
  'Major depressive disorder ( MDD ) represents a serious global health concern .',
  'Depression poses a serious economic problem .',
  'Nowadays , depression is a serious clinical problem , as the prevalence of its various forms increases and there are growing numbers of patients with severe forms of depression and treatment-refractory depression .',
  'Depression is a serious public health concern .',
  'Depression is a serious public health problem in Pakistan because of the disabilities it causes and the cost burden for the family .',
  'Depression is a common disorder considered to be a serious public health problem although clinicians encounter very different levels of severity and the treatment strategies are tailored according to this variability .',
  'Depressive disorder is a severe psychiatric problem all over the world .',
  'Underrecognition and undertreatment of affective disorders ( i.e. , major depressive disorder and bipolar affective disorder ) constitute a serious public health problem in this country .',
  'Depression is a serious problem for women , one that is , in some cases , related to the sociocultural environment .',
  'Depression can be a serious problem for HIV infected .',
  'Although depression is a treatable cause of suffering , disability and death , its identifcation and treatment continue to be a challenge in clinical practice and a severe problem for global public health .',
  'Considering that persisting depressive symptoms are associated with a range of unfavourable outcomes , the present data point to a serious problem in the treatment of MDD and the urgent need to further optimize antidepressive treatment strategies .',
  'The prevalence of mental depression has increased in recent years , and has become a serious health problem in most countries of the world , including India .',
  'Major depressive disorder ( MDD ) represents a serious health problem estimated to affect 350 million people globally .',
  'It is not known , however , if it is effective in individuals with partially remitted depressive disorder , which is a serious clinical problem in up to 50 - 60 % of treated patients .',
  'Major depressive disorder ( MDD ) is a serious mental health problem in modern society , which is difficult to identify and diagnose in the early stages .',
  'Depression is a serious health problem , with lifetime prevalence in the western world of 20 - 30 % .',
  'Major depressive disorder is a severe clinical problem across the globe , with a lifetime risk of 10%-30 % for women and 7%-15 % for men .',
  'Major depressive disorder ( MDD ) is a serious health concern worldwide .',
  'Depression is a serious disorder that affects hundreds of millions of people around the world and causes poor quality of life , problem behaviors , and limitations in activities of daily living .',
  'Depression is a serious mental health problem facing many women with physical disabilities that does not appear to be adequately addressed by health care professionals .',
  'Depressive disorders constitute a serious problem in the United States and around the world .',
  'Underdetection and undertreatment of depression is a serious problem in palliative care .',
  'Depression is a serious public health problem .',
  'Major depressive disorder ( MDD ) is a serious public problem , affecting 4 - 6 % of adolescents at any one time .',
  'The results of this study suggest that apathy is a severe problem in KS .',
  'Major depressive disorder ( MD ) is a debilitating public mental health problem with severe societal and personal costs attached .',
  'Depression is a severe mental disorder that challenges mental health systems worldwide as the success rates of all established treatments are limited .',
  'Most respondents agreed that depression in PLHIV is a serious problem ( 91 % ) and is associated with poorer HIV-related outcomes ( 62%-81 % ) .',
  'Major depression is a serious global health concern ; however , the pathophysiology underlying this condition remains unclear .',
  'Major depression affects more than 5 % of the population and is a serious health and economic problem .',
  'Major depressive disorder , or depression , becomes a serious public health problem globally .',
  'This flows from a recognition of depression as a serious and costly problem , with women carrying twice the risk of men .',
  'According to the World Health Organization , the alarming increase in rates of depression globally has become a serious concern .',
  'Depression has become a severe societal problem in China .',
  'Depression among PLWH is a severe problem in China .',
  'Depression is a life-threatening psychiatric disorder and a major public health concern worldwide with an incidence of 5 % and a lifetime prevalence of 15%-20 % .',
  'Depression has recently become a serious problem in society worldwide .',
  'Major depressive disorder ( MDD ) , a debilitating mental illness , could cause functional disabilities and could become a social problem .',
  'Refractory major depressive disorder ( MDD ) is a serious problem leading to a heavy economic burden .',
  'Depression is a common and impairing disorder which is a serious public health problem .',
  'The study \'s findings support the notion that a serious gap exists between the established efficacy of antidepressant medications and rates of treatment for major depression in the " real world . " Underreporting of depressive symptoms to providers and problems with access to general medical care appear to be 2 major contributors to this problem .',
  "On the patients ' side , sometimes sufferers do not notice the symptoms of depression by themselves , which may also be a serious problem .",
  'Depression is a debilitating mental health problem that tends to run a chronic , recurrent course .',
  'Major depressive disorder ( MDD ) is a highly prevalent debilitating psychiatric disease and a serious public health problem worldwide .',
  'The prevalence of depression worldwide is increasing from year to year and constitutes a serious medical , economic and social problem .',
  'Even with the best psychosocial and pharmacological treatments for unipolar depression , relapse is a serious problem .',
  'Major depression is a serious and often persistent problem for 5 to 10 percent of patients in primary care .',
  'Depression is increasingly threatening human health as a serious psychological problem .',
  'An increased incidence of depressive disorders observed in recent years in the Polish and world population is a serious health problem .',
  'Depression is a life-threatening psychiatric disorder and a multifactorial global public health concern .',
  'Major depressive disorder ( MDD ) is a serious U.S. public health problem for children and adolescents .'],
 'disorder': ['Depression is a serious mental health disorder and characterized by sadness, loss of interest in activities, and decreased energy.',
  'Early life adversity (ELA) is not uncommon in major depressive disorder (MDD) patients.',
  'Depression is an extremely common mental health disorder, with prevalence rates rising.',
  'Cognitive behaviour therapy (CBT) and interpersonal psychotherapy (IPT) are the most studied psychotherapies for treatment of depression, but they are rarely directly compared particularly over the longer term.',
  'Borderline personality disorder (BPD) is one of the most puzzling psychiatric disorders',
  'Depression is a disorder that is highly prevalent nowadays',
  'A major problem with current anti-depressant therapy is that it takes on average 6 - 7 weeks for remission .',
  'The delayed onset of therapeutic outcomes is a major drawback of the current antidepressants .',
  "Treatment-resistant depression is a serious problem with significant costs in terms of health care dollars and patients ' well-being .",
  'Major depressive disorder ( MDD ) is a serious US public health problem for children and adolescents .',
  'Depression , a mental illness characterized by persistent feeling of sadness and loss of interest , has been a serious health problem worldwide .',
  'Bipolar affective disorder ( BAD ) is a severe mental illness which results in serious lifelong struggles and challenges .',
  'Post-traumatic stress disorder ( PTSD ) is a serious problem not only among workers who experience industrial accidents but also among workers who witness such accidents .',
  'Posttraumatic stress disorder ( PTSD ) is a severe problem among soldiers with combating experience difficult to treat .',
  'Veteran populations are exposed to multiple stressful events , and suicidality among veterans is a serious problem .',
  'Posttraumatic stress disorder ( PTSD ) is a serious mental health concern for returning U.S. military personnel who have a higher prevalence rate of PTSD than the general population .',
  'Borderline personality disorder ( BPD ) is a severe mental condition characterized by a range of cognitive and behavioral vulnerabilities , including chronic shame and deficits in social problem solving ( SPS ) abilities .',
  'Major depression is a serious public health problem and one of the most common psychiatric disorders , and it is estimated that millions of people are affected worldwide .',
  'Major depressive disorder ( MDD ) represents a serious global health concern .',
  'Depression poses a serious economic problem .',
  'Mental health issues are a serious concern for many American Indian Veterans , especially for post-traumatic stress disorder and related psychiatric conditions .',
  'Borderline personality disorder ( BPD ) is a serious public health problem .',
  'Nowadays , depression is a serious clinical problem , as the prevalence of its various forms increases and there are growing numbers of patients with severe forms of depression and treatment-refractory depression .',
  'Depression is a serious public health concern .',
  'Depression is a serious public health problem in Pakistan because of the disabilities it causes and the cost burden for the family .',
  'Depression is a common disorder considered to be a serious public health problem although clinicians encounter very different levels of severity and the treatment strategies are tailored according to this variability .',
  'Depressive disorder is a severe psychiatric problem all over the world .',
  'Underrecognition and undertreatment of affective disorders ( i.e. , major depressive disorder and bipolar affective disorder ) constitute a serious public health problem in this country .',
  'Depression is a serious problem for women , one that is , in some cases , related to the sociocultural environment .',
  'Depression can be a serious problem for HIV infected .',
  'Borderline personality disorder is a serious mental health problem for which one of its main characteristics is significant difficulties in relationships with others .',
  'Although depression is a treatable cause of suffering , disability and death , its identifcation and treatment continue to be a challenge in clinical practice and a severe problem for global public health .',
  'Considering that persisting depressive symptoms are associated with a range of unfavourable outcomes , the present data point to a serious problem in the treatment of MDD and the urgent need to further optimize antidepressive treatment strategies .',
  'The prevalence of mental depression has increased in recent years , and has become a serious health problem in most countries of the world , including India .',
  'Posttraumatic stress disorder ( PTSD ) is a serious and global problem , a psychiatric disorder that frequently occurs with different comorbidities , and is associated with a high suicide rate .',
  'Inappropriate treatment of BPD is a serious problem in the US population .',
  'Major depressive disorder ( MDD ) represents a serious health problem estimated to affect 350 million people globally .',
  'It is not known , however , if it is effective in individuals with partially remitted depressive disorder , which is a serious clinical problem in up to 50 - 60 % of treated patients .',
  'Post Traumatic Stress Disorder ( PTSD ) can be a debilitating problem in service members who have served in Iraq or Afghanistan .',
  'Major depressive disorder ( MDD ) is a serious mental health problem in modern society , which is difficult to identify and diagnose in the early stages .',
  'Depression is a serious health problem , with lifetime prevalence in the western world of 20 - 30 % .',
  'Major depressive disorder is a severe clinical problem across the globe , with a lifetime risk of 10%-30 % for women and 7%-15 % for men .',
  'While post-traumatic stress disorder ( PTSD ) and other trauma- and stress-related disorders ( TSRDs ) represent a serious societal and public health concern , their pathogenesis is largely unknown .',
  'In multivariate analysis , PTSD was positively associated with the perception of stress as a serious problem ( OR \u2009 = \u2009 6.52 ; P-value \u2009 = \u2009 0.003 ) , safety and protection for women in the community ( OR \u2009 = \u2009 2.35 ; P-value \u2009 = \u2009 0.011 ) , care for family ( OR \u2009 = \u2009 2.00 ; P-value \u2009 = \u2009 0.035 ) and Place to live in ( OR \u2009 = \u2009 1.83 ; P-value \u2009 = \u2009 0.04 ) .',
  'Depression is a serious problem among military personnel returning from combat deployments , and is related to a range of adverse outcomes including alcohol and drug abuse , family violence and suicide .',
  'Dissociative symptoms including flashbacks , i.e. vivid scenic recollections of traumatic episodes , in patients with Borderline Personality Disorder are a serious and often treatment-refractory problem .',
  'Major depressive disorder ( MDD ) is a serious health concern worldwide .',
  'Depression is a serious disorder that affects hundreds of millions of people around the world and causes poor quality of life , problem behaviors , and limitations in activities of daily living .',
  'Depression is a serious mental health problem facing many women with physical disabilities that does not appear to be adequately addressed by health care professionals .',
  'Posttraumatic stress disorder ( PTSD ) is a debilitating trauma and stressor-related disorder that has become a major neuropsychiatric problem , leading to substantial disruptions in individual health and societal costs .',
  'Depressive disorders constitute a serious problem in the United States and around the world .',
  'Just as traumatic experiences may lead to posttraumatic stress disorder ( PTSD ) in some individuals , grief may also be a serious health concern for individuals who have experienced bereavement .',
  'This could be a serious problem for military or emergency personnel recalled to combat or a disaster site without sufficient time to deal with the effects of their initial experiences .',
  'Underdetection and undertreatment of depression is a serious problem in palliative care .',
  'Depression is a serious public health problem .',
  'Major depressive disorder ( MDD ) is a serious public problem , affecting 4 - 6 % of adolescents at any one time .',
  'The results of this study suggest that apathy is a severe problem in KS .',
  'Post-traumatic stress disorder ( PTSD ) is increasingly becoming recognised as a serious mental health problem ( Department of Health , 1991 ) .',
  'Major depressive disorder ( MD ) is a debilitating public mental health problem with severe societal and personal costs attached .',
  'PTSD represents a serious mental health problem after a disaster .',
  'Depression is a severe mental disorder that challenges mental health systems worldwide as the success rates of all established treatments are limited .',
  'Most respondents agreed that depression in PLHIV is a serious problem ( 91 % ) and is associated with poorer HIV-related outcomes ( 62%-81 % ) .',
  'Major depression is a serious global health concern ; however , the pathophysiology underlying this condition remains unclear .',
  'Major depression affects more than 5 % of the population and is a serious health and economic problem .',
  'Although PTSD may be a serious problem in some survivors of critical illness , data on the whole population are inconclusive .',
  'Posttraumatic stress disorder ( PTSD ) is a serious health concern .',
  'Major depressive disorder , or depression , becomes a serious public health problem globally .',
  'This flows from a recognition of depression as a serious and costly problem , with women carrying twice the risk of men .',
  'According to the World Health Organization , the alarming increase in rates of depression globally has become a serious concern .',
  'PTSD is a serious public health concern , which compels the search for novel paradigms and theoretical models to deepen the understanding of the condition and to develop new and improved modes of treatment intervention .',
  'Depression has become a severe societal problem in China .',
  'Depression among PLWH is a severe problem in China .',
  'Depression is a life-threatening psychiatric disorder and a major public health concern worldwide with an incidence of 5 % and a lifetime prevalence of 15%-20 % .',
  'Premature termination from group psychotherapy continues to be a serious problem in the treatment of patients with borderline personality disorder ( BPD ) .',
  'Benzodiazepines and selective serotonin reuptake inhibitors ( SSRIs ) are considered the gold standard for PTSD treatment , but their side effects pose a serious problem .',
  'Depression has recently become a serious problem in society worldwide .',
  'Major depressive disorder ( MDD ) , a debilitating mental illness , could cause functional disabilities and could become a social problem .',
  'Refractory major depressive disorder ( MDD ) is a serious problem leading to a heavy economic burden .',
  'Bipolar Disorder ( BD ) is a severe mental health problem .',
  'Depression is a common and impairing disorder which is a serious public health problem .',
  'The study \'s findings support the notion that a serious gap exists between the established efficacy of antidepressant medications and rates of treatment for major depression in the " real world . " Underreporting of depressive symptoms to providers and problems with access to general medical care appear to be 2 major contributors to this problem .',
  "On the patients ' side , sometimes sufferers do not notice the symptoms of depression by themselves , which may also be a serious problem .",
  'Depression is a debilitating mental health problem that tends to run a chronic , recurrent course .',
  'Bipolar affective disorder is a serious and enduring mental health problem , which is associated with high mortality rates worldwide .',
  'Major depressive disorder ( MDD ) is a highly prevalent debilitating psychiatric disease and a serious public health problem worldwide .',
  'The prevalence of depression worldwide is increasing from year to year and constitutes a serious medical , economic and social problem .',
  'Even with the best psychosocial and pharmacological treatments for unipolar depression , relapse is a serious problem .',
  'Major depression is a serious and often persistent problem for 5 to 10 percent of patients in primary care .',
  'Depression is increasingly threatening human health as a serious psychological problem .',
  'An increased incidence of depressive disorders observed in recent years in the Polish and world population is a serious health problem .',
  'Borderline personality disorder ( BPD ) is a severe and generally chronic disorder that presents patients and their family members with multiple challenges .',
  'Depression is a life-threatening psychiatric disorder and a multifactorial global public health concern .',
  'Major depressive disorder ( MDD ) is a serious U.S. public health problem for children and adolescents .'],
 'occupational': ["Currently, table saws sold in the United States have 3 safety features (riving knife, blade guard, and antikickback device) designed to prevent personal injury; however, these features can hinder the user's movements and are often disabled or removed.",
  'Maintaining adequate working ability of construction workers is of considerable importance for society, as the construction sector is burdened with high prevalence of work-related diseases and health-issues.',
  'A fundamental problem with classifying agriculturally related injury is that there is neither a rational nor a comprehensive scheme for grouping incidents into categories describing actual exposures encountered on farms and in agricultural work .',
  'Accident proneness : a serious industrial problem .',
  'Accident proneness ; a serious industrial problem . What can the industrial physician do about it ?',
  'Injury in Canada is a serious public health concern .',
  'As China has gradually transformed from agricultural economy into industrial economy since 1978 , occupational injuries and diseases become a serious social problem in China .',
  'Needlestick injuries are a serious , but preventable problem in the healthcare industry .',
  'Accidental sharps injuries are a serious problem in healthcare , many healthcare workers acquire infectious diseases from bloodborne pathogens by sharps injuries during their work .',
  'Occupational injuries , which kill over 300,000 people annually , are a serious public health concern .',
  'With increasing electrification and mechanization in rural areas , industrial drive-belt or patta injuries have posed a serious problem .',
  'The burden of work injuries in Canada is a serious public health concern .',
  'The annual increase in the number of occupational accidents and diseases in the Palestinian manufacturing industries confirms a serious problem that threatens the Occupational Safety and Health ( OSH ) in such industries , with negative consequences in the society and economy .',
  'Injuries associated with the category of dental surgical instruments known as " sharps " ( i.e. , syringe needles , glass , scalpel blades , dental burs , and hand instruments ) are a serious concern for dental professionals because of the possible transmission of communicable diseases such as tuberculosis , hepatitis B virus , hepatitis C virus , and human immunodeficiency virus ( HIV ) .',
  'Previous reports have indicated that injuries involving augers ( screw conveyors ) are a serious problem in agriculture , but to date on-site engineering inspections linking injuries to mechanical and procedural aspects have not been available .',
  'There are many occupational hazards in electronic industry . And there is somewhat a serious occupational and reproductive health problems among female migrant workers , that seem to be a matter of great concern .',
  'Needlestick injuries are a serious concern for nurses and other healthcare workers .',
  'Despite continuous progress in medicine and improvement of quality of work , occupational diseases are still a serious problem .',
  'Workplace injuries are a serious public health problem , potentially leading to loss of earnings , medical expenses , disability and even death for working people .',
  'Premature mortality due to occupational injury is still a serious problem in the Iranian population .',
  'As many as 45 % of injuries were not officially recorded ; ( 4 ) Conclusion : High rates of work-related accidents and injuries caused by sharp instruments in paramedics are a serious public health problem . Further studies should be conducted in order to identify risk factors of accidents , particularly injuries , and to implement preventative programmes , aiming to minimise rates of occupational hazards for paramedics .',
  'Occupational health has become a serious problem in the developing world as new industries and accelerating ecnomic development occur without adequate resources for worker protection .',
  'Hazardous child labor in Nepal is a serious concern , particularly in the brick kiln industry .',
  'Occupational accidents and injuries present a serious social , medical and economical problem in Serbian industries in transition .',
  'The healthy worker effect ( HWE ) poses a serious methodological problem to investigators of occupational cohorts in that it may mask mortality excesses that result from occupational exposures .',
  'Occupational risks are becoming a serious problem in developing countries , largely as a consequence of the transfer of hazardous industries from industrialized countries where certain industries are judged to be unacceptable .',
  'Sharps injuries continue to be a serious concern for all healthcare workers .'],
 'diabetic': ['Diabetic foot ulcer is considered as a major health problem that predisposes to limb amputation.',
  'Diabetic kidney disease (DKD) is 1 of the common microvascular complications of diabetes, and the therapeutic effect of modern medicine on DKD is limited',
  'Diabetes mellitus is a debilitating health care problem affecting 382 million people around the world and one of the most common complications is diabetic nephropathy .',
  'Foot ulceration ( FU ) remains a serious concern for patients worldwide .',
  'Diabetes mellitus is a serious health problem in the world and about 20 to 40 % of the patients are being affected with diabetic nephropathy .',
  'Impaired wound healing is a serious concern of uncontrolled hyperglycemia that can lead to gangrene , and even death .',
  'Ulcers of the skin of the feet of diabetic patients are a serious health problem and a major cause of amputations .',
  'The risk of infection is higher and infections are a serious clinical problem in patients with type 1 ( insulin-dependent ) diabetes mellitus ( T1DM ) .',
  'Diabetic renal disease is a serious problem resulting from microvascular complications in both type 1 and type 2 diabetes mellitus .',
  'Diabetic renal disease is a serious problem resulting from microvascular complications in both type 1 and type 2 diabetes mellitus .',
  'Foot ulceration remains a serious health concern for diabetic patients and has a major impact on the cost of diabetes treatment .',
  'Lower leg ulcers in DM are very persistent and constitute a serious medico-social problem to be addresses based at Diabetic Foot cabinets .',
  'Diabetes mellitus is a serious public health problem in which a major complication is impaired wound healing .',
  'The unknown mechanisms of impaired tissue repair in diabetes mellitus are making this disease a serious clinical problem for the physicians worldwide .',
  'Diabetic kidney disease ( DKD ) is a serious disease that presents a major health problem worldwide .',
  'Diabetic foot ulcers ( DFU ) represent a severe health problem and an unmet clinical challenge .',
  'Complications of diabetes affecting the feet represent a serious problem in China .',
  'Chronic wounds , such as diabetic foot ulcers , represent a serious clinical problem for patients and clinicians .',
  'Delayed repair is a serious public health concern for diabetic populations .',
  'Diabetes mellitus is currently a serious public health problem worldwide , that increases the risk of presenting microvascular and macrovascular complications .',
  'Impaired diabetic wound healing represents a devastating and rapidly growing clinical problem associated with high morbidity , mortality , and recurrence rates .',
  'Diabetic nephropathy ( DN ) that progress to end stage renal failure is a serious health problem .',
  'Diabetes-related chronic cutaneous lesions are a serious and common problem , as well as a major cause for hospital admissions , although no general consensus has been reached on the best available treatment for this frequent pathological condition .',
  'In many instances , a diabetic foot poses a serious health problem due to its multiple complications .',
  'Impaired wound healing is a serious problem for diabetic patients .',
  'Wound healing is a troublesome problem in diabetic patients .',
  'Chronic wounds such as diabetic ulcers are a serious public health problem .',
  'With a developing worldwide epidemic of diabetes mellitus , the renal complications associated with diabetes have become a serious health concern .',
  'Foot ulceration is a serious problem for patients with type 2 diabetes ( T2D ) , and the early detection of risks for this condition is important to prevent complications .',
  'With worldwide epidemic of diabetes mellitus , diabetic nephropathy which is one of the major causes of microvascular complication has become a serious concern in Korea as well as the rest of the world .',
  'Nowadays diabetic nephropathy ( DN ) has become a serious problem .',
  'Impaired wound healing is a complication of diabetes and is a serious problem in clinical practice .',
  'Diabetic angiopathy is a serious problem in antidiabetic therapy .',
  'Diabetic foot ulcers ( DFUs ) are a serious and common problem in patients with diabetes mellitus and constitute one of the major causes of lower extremity amputation .',
  'Impaired wound healing is a complication of diabetes and a serious problem in clinical practice .',
  'Peripheral vascular disease is a serious and frequent problem in diabetic patients .',
  'In diabetic patients , impairment of wound healing is a serious problem which represents a significant health burden .',
  'Diabetic foot is a serious problem for health care systems .',
  'Ulcers as a result of diabetes mellitus are a serious problem with an enormous impact on the overall global disease burden due to the increasing prevalence of diabetes .',
  'Diabetic nephropathy ( DN ) is a serious complication of diabetes mellitus ( DM ) , which is a major public health problem in the world .',
  'Diabetic kidney disease , a leading cause of end-stage renal disease , has become a serious public health problem worldwide and lacks effective therapies .',
  'Diabetic foot ulcers are a serious cause of diagnostic and therapeutic concern .',
  'Prolonged healing is a severe problem for elderly and diabetic patients .',
  'SSFN may be a serious factor in observations of impaired wound healing among obese subjects , a particularly worrisome problem in an obese aging population given the propensity for small fiber impairment in aging subjects .',
  'Diabetic nephropathy ( DN ) has become a serious public health problem .',
  'Diabetic foot ulceration is currently a serious medical problem and has , therefore , attracted much research attention during the last two decades .',
  'Diabetic foot ulcers ( DFU ) remain a serious public health problem .',
  'Kidney disease is a serious development in diabetes mellitus and poses an increasing clinical problem .',
  'Lower leg ulcers are a serious and long-term complication in patients with diabetes and pose a major health concern because of the increasing number of patients diagnosed with diabetes each year .',
  'Diabetic kidney disease ( DKD ) , a leading cause of end-stage renal disease ( ESRD ) , has become a serious public health problem worldwide and lacks effective therapies due to its complex pathogenesis .',
  'Diabetic foot ulcer is a life-threatening clinical problem in diabetic patients .',
  'Foot infections commonly occur in diabetic patients , constituting a serious problem .'],
 'ulcers': ['Diabetic foot ulcer is considered as a major health problem that predisposes to limb amputation.',
  'We conclude that pressure ulcers represent a serious clinical and economic problem for a resource-constrained public hospital system .',
  'Pressure sores are a serious problem among geriatric patients in nursing homes .',
  'Hospital-acquired pressure ulcers are a serious patient safety concern , associated with poor patient outcomes and high healthcare costs .',
  'The cutaneous ulcer in a patient with a history of international travel poses a vexing diagnostic dilemma for the clinician .',
  'Hospital-acquired pressure ulcers ( HAPUs ) are a serious nosocomial problem that has been viewed as a ubiquitous consequence of immobility .',
  'Paediatric pressure ulcers are a serious problem to healthcare service .',
  'Foot ulceration ( FU ) remains a serious concern for patients worldwide .',
  'Ulcers of the skin of the feet of diabetic patients are a serious health problem and a major cause of amputations .',
  'Pressure ulcers are a serious health problem for people with mobility disorders , like elders in acute care , long-term care , and home care settings .',
  'Foot ulceration remains a serious health concern for diabetic patients and has a major impact on the cost of diabetes treatment .',
  'Chronic , nonhealing , cutaneous ulcers are a serious clinical problem .',
  'Lower leg ulcers in DM are very persistent and constitute a serious medico-social problem to be addresses based at Diabetic Foot cabinets .',
  'Pressure ulcers ( PUs ) are a serious health problem .',
  'Diabetic foot ulcers ( DFU ) represent a severe health problem and an unmet clinical challenge .',
  'Complications of diabetes affecting the feet represent a serious problem in China .',
  'Pressure ulcers ( PUs ) continue to be a distressing medical problem .',
  'Peptic ulcer perforation is a serious problem that leads to high complication and mortality rates .',
  'Pressure ulcers are a serious national health concern impacting cost of care , reimbursement , and quality of life .',
  'Chronic ulceration as a complication of arteriosclerotic disease , venous congestion or diabetes mellitus is still a serious clinical problem , resulting in immobilization , extended hospitalization and cost-intensive treatment .',
  'Chronic wounds , such as diabetic foot ulcers , represent a serious clinical problem for patients and clinicians .',
  'Pressure sores are a severe and costly problem for many disabled individuals .',
  'Pressure ulcers are still a serious problem for the hospitalized patient in this country .',
  'Peptic ulcer bleeding is a serious medical problem with significant morbidity and mortality .',
  'The study documents that the development of pressure sores in Danish hospital patients is not a serious quality problem .',
  'Over the years , the aeromedical disposition of aircrew members with bleeding duodenal ulcer has been a vexing problem because two essential questions can not be categorically answered :',
  'The urgency treatment of a life-threatening bleeding for Cameron ulcers remains a very challenging problem as no univocal and standardized recommendation has been described in literature since now .',
  'Pressure sores are a serious but often avoidable problem .',
  'Recurrent pressures sores are a serious problem that often cause chronically ill patients to be hospitalized .',
  'In many instances , a diabetic foot poses a serious health problem due to its multiple complications .',
  'On account of its frequency , its severe sequelae for individual and society and an account of the hitherto insufficient possibilities for prevention and cure the peptic ulcer of the stomach and the duodenum is a severe problem in health policy .',
  'The lower extremity vascular ulcers currently represent a major public health problem , particularly because of different situations : the chronic nature of the injury , a poor response to treatment , recurrence rates , high absenteeism , poor training in some cases of the health staff that treats , etc . Lower extremity ulcers mean a serious personal , family , health and social problem , with a significant expenditure of human and material resources .',
  'Chronic wounds such as diabetic ulcers are a serious public health problem .',
  '1 . Pressure ulcers continue to be a serious problem in nursing home settings .',
  'Foot ulceration is a serious problem for patients with type 2 diabetes ( T2D ) , and the early detection of risks for this condition is important to prevent complications .',
  'Pressure ulcer development is a serious problem occurring predominately among elderly persons , who are confined to bed or chair .',
  'Healing of ulcers is a serious problem , but preventing recurrence is the greater challenge .',
  'Pressure ulcers are serious and common health concern affecting about 1.5 - 3 million adults and is a serious health concern for elders .',
  'Pressure ulcer development during a surgical procedure is a serious problem .',
  'Pressure ulcers ( PUs ) are considered a serious problem in nursing care and require preventive measures .',
  'Pressure ulcers on heels are a serious problem in nursing home patients and can lead to complications .',
  'Diabetic foot ulcers ( DFUs ) are a serious and common problem in patients with diabetes mellitus and constitute one of the major causes of lower extremity amputation .',
  'Pressure ulcers are a serious health problem in medical and nursing care .',
  'Pressure ulcer is a serious and persistent problem for patients throughout the Western world .',
  'The Pressure Ulcer Scale for Healing ( PUSH ) represent a serious problem around the world since they have important consequences , personal and economic , this making it a public problem health .',
  'Lower limb ulcers are a serious medical and socioeconomic problem throughout the world .',
  'The data available regarding the epidemiology of pressure ulcers suggest that they are a serious public health problem in the United States , particularly among the elderly .',
  'Diabetic foot is a serious problem for health care systems .',
  'Pressure ulcers ( PU ) remain a serious healthcare problem in the United States .',
  'Ulcers as a result of diabetes mellitus are a serious problem with an enormous impact on the overall global disease burden due to the increasing prevalence of diabetes .',
  "Venous crural ulcer is a serious medical problem indeed , which is connected with patients ' suffering and long term treatment generating high cost .",
  'Even in the present , pressure ulcers still represent a severe health problem , particularly in Intensive Care Units ( ICU ) .',
  'Diabetic foot ulcers are a serious cause of diagnostic and therapeutic concern .',
  'Pressure ulcer is a serious problem during patient care processes .',
  'Wound pain is a serious problem for elderly patients suffering from chronic leg ulcers , and it may lead to reduced wound healing rates and reduced quality of life .',
  'Stress induced gastric ulcer is a serious health problem in diabetic patients .',
  'Diabetic foot ulceration is currently a serious medical problem and has , therefore , attracted much research attention during the last two decades .',
  'Diabetic foot ulcers ( DFU ) remain a serious public health problem .',
  'Pressure ulcers are a serious problem that can lead to pain and delayed recovery .',
  'Pressure ulcers , a devastating and costly healthcare problem , often occur in home healthcare settings .',
  'Pressure ulcers remain a serious problem for patients and providers in healthcare .',
  'Varicose ulcers ( UV ) are a serious health problem which produce tremendous pain for those who suffer from them ; furthermore , they consume a large amount of health care system resources .',
  'Pressure ulcers ( PUs ) are a serious health care problem for nursing home residents and a key quality metric for regulators .',
  'Lower leg ulcers are a serious and long-term complication in patients with diabetes and pose a major health concern because of the increasing number of patients diagnosed with diabetes each year .',
  'Leg ulcers are a serious problem for those affected by them , and health care providers need to be more informed about the effect of chronic health problems on elderly persons .',
  'Diabetic foot ulcer is a life-threatening clinical problem in diabetic patients .',
  'Preventing and treating pressure ulcers will continue to be a troublesome problem for intensivists .',
  'Pain is a serious problem for patients with leg ulcers .',
  'Foot infections commonly occur in diabetic patients , constituting a serious problem .',
  'Peptic ulcer ( PU ) perforation is a serious problem that leads to high complication and mortality rates .',
  'Pressure ulcers are a serious health issue , leading to clinical , financial , and emotional challenges .',
  'Pressure ulcers remain a serious health problem , especially in terms of personal suffering and economics .'],
 'ulceration': ['Diabetic foot ulcer is considered as a major health problem that predisposes to limb amputation.',
  'Foot ulceration ( FU ) remains a serious concern for patients worldwide .',
  'Ulcers of the skin of the feet of diabetic patients are a serious health problem and a major cause of amputations .',
  'Foot ulceration remains a serious health concern for diabetic patients and has a major impact on the cost of diabetes treatment .',
  'Lower leg ulcers in DM are very persistent and constitute a serious medico-social problem to be addresses based at Diabetic Foot cabinets .',
  'Diabetic foot ulcers ( DFU ) represent a severe health problem and an unmet clinical challenge .',
  'Complications of diabetes affecting the feet represent a serious problem in China .',
  'Chronic wounds , such as diabetic foot ulcers , represent a serious clinical problem for patients and clinicians .',
  'In many instances , a diabetic foot poses a serious health problem due to its multiple complications .',
  'Chronic wounds such as diabetic ulcers are a serious public health problem .',
  'Foot ulceration is a serious problem for patients with type 2 diabetes ( T2D ) , and the early detection of risks for this condition is important to prevent complications .',
  'Diabetic foot ulcers ( DFUs ) are a serious and common problem in patients with diabetes mellitus and constitute one of the major causes of lower extremity amputation .',
  'Diabetic foot is a serious problem for health care systems .',
  'Ulcers as a result of diabetes mellitus are a serious problem with an enormous impact on the overall global disease burden due to the increasing prevalence of diabetes .',
  'Diabetic foot ulcers are a serious cause of diagnostic and therapeutic concern .',
  'Diabetic foot ulceration is currently a serious medical problem and has , therefore , attracted much research attention during the last two decades .',
  'Diabetic foot ulcers ( DFU ) remain a serious public health problem .',
  'Lower leg ulcers are a serious and long-term complication in patients with diabetes and pose a major health concern because of the increasing number of patients diagnosed with diabetes each year .',
  'Diabetic foot ulcer is a life-threatening clinical problem in diabetic patients .',
  'Foot infections commonly occur in diabetic patients , constituting a serious problem .'],
 'stroke': ['Depressiveness is a\xa0known and common problem after stroke, which puts a great burden on those affected.',
  'Levels of physical activity after stroke are low, despite multiple health benefits.',
  'Sequelae after a stroke are common and may lead to disability.',
  'Stroke is the leading cause of long-term disability.',
  'Depression is common in patients with ischaemic heart disease and preoperative depression is a risk factor following coronary artery bypass grafting.',
  'Stroke is the leading cause of mortality and disability worldwide',
  'Stroke is among the leading causes of acquired disability in the United States, affecting nearly 800,000 Americans annually',
  'Anosognosia for hemiplegia (AHP) after stroke is a complex cognitive behavioral disorder that removes awareness of one-sided paralysis (hemiplegia)',
  '• Cerebrovascular disease represents a major source of global mortality and morbidity • Imaging examinations play a critical role in the management of stroke patients • The penumbra may be seen with both CT and MRI ; however , this concept may be overly simplistic • The major drawback of CT is the high radiation dose , while MRI is a more complicated examination .',
  'Stroke is a devastating condition with recognized challenges in identifying effective prevention programs .',
  'Stroke has been considered a serious public health problem in many countries , accounting for complex disorders involving perception , such as visual , cognitive and functional deficits .',
  'To enhance stroke literacy , a complete message should include the following 4 aspects : ( 1 ) a stroke is a serious medical problem that involves the blood supply to the brain , ( 2 ) all 5 approved warning signs and symptoms , ( 3 ) the many risk factors involved in stroke , and ( 4 ) the need to promptly call 911 for emergency services and treatment .',
  'Stroke is a severe health problem , and magnetic resonance imaging ( MRI ) plays a significant role in stroke .',
  'Acute ischemic stroke ( AIS ) is a major cause of mortality and disability and remains a serious and significant global health problem .',
  'Stroke , broadly subdivided into ischemic and hemorrhagic subtypes , is a serious health-care problem worldwide .',
  'In the Latin American context , stroke mortality rates in Costa Rica are low but still represent a serious public health problem by the high mortality , morbidity and disability that they cause , despite a downward trend .',
  'Acute cerebrovascular disease is a serious neurological problem .',
  'Poststroke depression ( PSD ) is a severe problem ; it will significantly increase the mortality of patients after stroke , and affect the quality of life of patients after discharge .',
  'Stroke is a serious health problem , given it is the second leading cause of death and a major cause of disability in the European Union .',
  'Stroke is a serious public health problem that causes morbidity and mortality throughout the world .',
  'Ischemic cerebral infarcts represent a serious health problem with important social and economic repercussions in the western world .',
  'Acute brain injury , such as intracerebral hemorrhage is a serious problem .',
  'In acquired adult brain damage , spasticity is a severe and frequent problem , appearing in 20 - 30 % of patients with stroke and in 13 - 20 % of patients with moderate-severe traumatic brain injury .',
  'Ischemic stroke has become a serious public health problem , which is in need of advanced research on the prevention and treatment .',
  'Stroke , due to its worldwide prevalence , is not only a medical challenge , but also a serious social problem .',
  "Its CNS symptoms represent a serious problem , since therapeutics for Wilson 's disease do not cross the BBB .",
  'Cerebrovascular accident is a serious public health problem and requires the attention of professionals who can detect , diagnose , and provide care in a timely fashion .',
  'Depression following acute coronary syndrome ( ACS ) constitutes a serious and debilitating problem .',
  'Mental fatigue is for many a distressing and long-term problem after stroke .',
  'The latter group in particular may present a serious diagnostic problem , as several groups have recently reported patients suffering from lower motor neuron syndrome without detectable conduction block , who responded unexpectedly to treatment with immunoglobulins .',
  'Progressive stroke is a serious problem due to the associated morbidity and mortality .',
  'Especially , fluctuating plasma ammonia often causing neurological signs and symptoms is a serious problem in the daily life .',
  'Although bleeding is a serious and potentially fatal complication of these injuries , the main concern should be the impairment of cerebral blood supply .',
  'Amyotrophic lateral sclerosis is a devastating disorder for which the psychological consequences of both the diagnosis announcement and the evolution of paralysis not only concern the patient but also his family .',
  'Post-stroke neural damage is a serious health concern which does not yet have an effective treatment .',
  'Stroke is a serious global health care problem .',
  'Stroke has become a serious public health problem in China .',
  'The number of stroke patients is increasing , and stroke represents a serious problem from the viewpoint of the national medical economy .',
  'Stroke-induced lower extremity dysfunction has become a severe medical problem nowadays and effective rehabilitation methods are in great demand .',
  'An argument is made that small-vessel stroke , which usually results in lacunar infarction , is a serious medical problem .',
  'Ischemic stroke ( IS ) still constitutes a serious problem for public health worldwide .',
  'Neurological complications represent a serious problem and their incidence rate is hard to reduce .',
  ': Post-stroke insomnia ( PSI ) is a serious problem which has significant adverse effects on the subsequent recovery of patients and the quality of their daily life .',
  'Acute stroke is a serious concern in emergency department ( ED ) dizziness presentations .',
  'She was transferred to a tertiary center with a severe headache and a nonreactive pupil , raising concern for evolving third nerve palsy due to aneurysm .',
  'A serious and ongoing problem is that life-threatening ischemic , hemorrhagic and inflammatory diseases of the central nervous system may cause identical symptoms , making it difficult to differentiate between them .',
  'Ischemic stroke remains a vexing public health problem .',
  'Acute ischemic stroke ( AIS ) has become a serious health problem in many countries because of its poor outcome and worsening epidemic trend .',
  'This study concludes that hemorrhagic stroke is indeed a serious health problem in Hong Kong .',
  'Progression of focal stroke symptoms still constitutes a serious clinical problem for which heparin has insufficient effectiveness in clinical practice .',
  'RN is a serious clinical problem often associated with devastating neurologic complications .',
  'Depression after stroke is a distressing problem that may be associated with other negative health outcomes .',
  'Stroke serves as a life-threatening disease and continues to face many challenges in the development of safe and effective therapeutic options .',
  'Stroke represents a severe and growing health problem in the general population .',
  'Stroke continues to be a serious socioeconomic problem in the industrialized countries .',
  'The silent stroke or white matter abnormalities in the vicinity of the lateral ventricle observed in CT or MRI have become a serious clinical problem and these are generally considered risk factors for stroke .',
  'Stroke presents a serious health problem in China .',
  'Given that stroke is currently a serious problem in the population , employing more reliable and objective techniques for determining diagnosis and prognosis is necessary in order to enable effective clinical decision-making .',
  'Stroke constitutes a serious socioeconomic and health care problem in women because it is the principal cause of incapacity and the first cause of death in this section of the population in several countries .',
  'Stroke is a serious health problem and is chiefly a disorder of the elderly population .',
  'Approximately , one-third of them are affected by post-stroke depression ( PSD ) , making it a serious social and public health problem and anti-depressant preventive and curative therapies worth investigating .',
  'Stroke continues to be a serious and significant health problem in the USA and worldwide .',
  'Ischemic stroke is a serious public health problem worldwide .',
  'Stroke is a serious healthcare problem with high mortality and long-term disability .',
  "In the era of an aging society and suffering from a number of risk factors , in particular those modifiable , strokes and muscles ' spastic paresis , subsequently resulting in damage of upper motor neuron structures will become a serious problem for the entire health care system .",
  'Stroke is a serious health problem in many countries .',
  'Nonpersistence of warfarin treatment becomes a serious problem for stroke prevention in Chinese patients with nonvalvular AF .',
  'Cognitive impairment induced by cerebral infarction has become a devastating health problem .',
  'Stroke is also a serious concern in patients with AVS .',
  'Approximately , one-third of stroke survivors are affected by post-stroke depression ( PSD ) , making it a serious social and public health problem .',
  'BACKGROUND Stroke is a serious health problem all over the world .',
  'A stroke can be a serious and debilitating health problem .',
  'Psychological and functional implications of the paralysis present a devastating management problem to those afflicted , as well as the carriers .',
  'Cerebral stroke is a serious worldwide health problem , as can be seen by the global epidemic of the disease .'],
 'dementia': ['Several observational studies have shown that exercise reduces the risk of cognitive decline; however, evidences from long-term, well-conducted, randomized controlled trials are scanty.',
  'Up to 50% of heart failure patients demonstrate aspects of cognitive impairment, including memory deficit.',
  "As Australia's aging population increases and diversifies, there will be a growing need to address the burden of dementia among culturally and linguistically diverse (CALD) communities",
  'Dementia is a growing global public health concern, with post-diagnostic care often very limited',
  'People with a migration background are vulnerable to dementia',
  'Dementia is a serious and growing public health problem in the United States .',
  'Although it is a serious health concern , little is known about the severity of the physical and health-related deficits in high-functioning fearful seniors .',
  'Confusion on a somatic basis is a dangerous problem mainly related with aging of the population .',
  'Age-related cognitive decline is a serious health concern in our aging society .',
  'Loss of cognitive function is a feared age-associated condition and growing public health concern .',
  'Information about the epidemiology of dementia in Italy is still limited , although this cognitive disorder represents a serious public health concern .',
  'Dementia is a serious and growing problem that presents enormous burdens to patients , their families , and national healthcare systems throughout the world .',
  "Agitation and other noncognitive abnormalities in patients with Alzheimer 's disease are present in at least 50 % of patients and are a serious problem for caregivers .",
  'Dementia is a devastating personal tragedy , a cause of tremendous family strife , and a significant societal dilemma both medically and economically .',
  'The absence of validated and culturally adapted assessment tools for the Luxembourgish context is a serious problem in the diagnosis of cognitive deficits of either origin .',
  'Dementia is a serious personal , medical and social problem .',
  'Preliminary data suggest that morning bright light might improve symptoms of agitation , a serious problem in patients with dementia .',
  'Cognitive decline in older adults is a serious public health problem today .',
  'Cognitive decline is a severe concern of patients with mild cognitive impairment .',
  'Dementia is a serious , chronic , and costly public health problem .',
  'Agitation is a serious problem for elderly individuals with dementia .',
  "Cognitive decline or dementia is a debilitating problem of neurological disorders such as Alzheimer 's and Parkinson 's disease , including special conditions like chemobrain .",
  'In our aging world , dementia is prevalent and is a serious health concern affecting approximately 35.6 million people worldwide .',
  'Increasing prevalence of cognitive impairment in an aging canine population poses a serious health problem .',
  'Dementia is fast becoming a serious public health concern .',
  "Getting lost ( GL ) is a serious problem for people living with Alzheimer 's disease ( PwAD ) , causing psychological distress in both PwAD and caregivers , and increasing the odds of being institutionalized .",
  'Dementia has became a serious health problem in developed countries .',
  'Dementia among elderly is a serious problem worldwide .',
  'The increase in the number of people suffering from dementia because of aging is a serious problem for caregivers since the feature of this pathology is irreversible and advancing .',
  'Dementia is a serious public health problem .',
  'Dementia is a serious and growing health problem , and since most people with dementia live at home , caring responsibilities generally fall on family members .',
  'The dramatic increase in the number of older people with Mild Cognitive Impairment ( MCI ) entails a serious public health problem .',
  'Dementia is a serious public health problem .'],
 'cognitive': ['Several observational studies have shown that exercise reduces the risk of cognitive decline; however, evidences from long-term, well-conducted, randomized controlled trials are scanty.',
  'Up to 50% of heart failure patients demonstrate aspects of cognitive impairment, including memory deficit.',
  "As Australia's aging population increases and diversifies, there will be a growing need to address the burden of dementia among culturally and linguistically diverse (CALD) communities",
  'Dementia is a growing global public health concern, with post-diagnostic care often very limited',
  'People with a migration background are vulnerable to dementia',
  'Dementia is a serious and growing public health problem in the United States .',
  'Although it is a serious health concern , little is known about the severity of the physical and health-related deficits in high-functioning fearful seniors .',
  'Confusion on a somatic basis is a dangerous problem mainly related with aging of the population .',
  'Age-related cognitive decline is a serious health concern in our aging society .',
  'Loss of cognitive function is a feared age-associated condition and growing public health concern .',
  'Information about the epidemiology of dementia in Italy is still limited , although this cognitive disorder represents a serious public health concern .',
  'Dementia is a serious and growing problem that presents enormous burdens to patients , their families , and national healthcare systems throughout the world .',
  "Agitation and other noncognitive abnormalities in patients with Alzheimer 's disease are present in at least 50 % of patients and are a serious problem for caregivers .",
  'Dementia is a devastating personal tragedy , a cause of tremendous family strife , and a significant societal dilemma both medically and economically .',
  'The absence of validated and culturally adapted assessment tools for the Luxembourgish context is a serious problem in the diagnosis of cognitive deficits of either origin .',
  'Dementia is a serious personal , medical and social problem .',
  'Preliminary data suggest that morning bright light might improve symptoms of agitation , a serious problem in patients with dementia .',
  'Cognitive decline in older adults is a serious public health problem today .',
  'Cognitive decline is a severe concern of patients with mild cognitive impairment .',
  'Dementia is a serious , chronic , and costly public health problem .',
  'Agitation is a serious problem for elderly individuals with dementia .',
  "Cognitive decline or dementia is a debilitating problem of neurological disorders such as Alzheimer 's and Parkinson 's disease , including special conditions like chemobrain .",
  'In our aging world , dementia is prevalent and is a serious health concern affecting approximately 35.6 million people worldwide .',
  'Increasing prevalence of cognitive impairment in an aging canine population poses a serious health problem .',
  'Dementia is fast becoming a serious public health concern .',
  "Getting lost ( GL ) is a serious problem for people living with Alzheimer 's disease ( PwAD ) , causing psychological distress in both PwAD and caregivers , and increasing the odds of being institutionalized .",
  'Dementia has became a serious health problem in developed countries .',
  'Dementia among elderly is a serious problem worldwide .',
  'The increase in the number of people suffering from dementia because of aging is a serious problem for caregivers since the feature of this pathology is irreversible and advancing .',
  'Dementia is a serious public health problem .',
  'Dementia is a serious and growing health problem , and since most people with dementia live at home , caring responsibilities generally fall on family members .',
  'The dramatic increase in the number of older people with Mild Cognitive Impairment ( MCI ) entails a serious public health problem .',
  'Dementia is a serious public health problem .'],
 'herpes': ['Research results on the efficacy of sunblock sticks in avoiding or reducing Herpes labialis (HL) recurrences are contradictory and has shown mixed results, with some protection reported under experimental conditions that could not be replicated under natural conditions.',
  'Postherpetic itch has not commonly received attention as a complication of herpes zoster because pain predominates over itch in most patients with herpes zoster',
  'As opportunistic infections among human T-lymphotrophic virus type 1 ( HTLV-1 ) carriers and patients with adult T-cell leukemia/lymphoma ( ATL ) pose a serious problem , it is necessary to clarify their clinical characteristics and outcomes in these patients .',
  'Despite the availability of antiviral chemotherapy , herpes simplex virus type 1 ( HSV-1 ) and type 2 ( HSV-2 ) infections remain a severe global health problem .',
  'HSV infection is a serious problem due to : the increasing number of cases ; its ability to remain latent in the host and periodically cause recurrent infection ; and lack of effective treatment .',
  'Primary varicella infection remains a serious problem in immunocompromised patients .',
  'Ocular infection with HSV-1 continues to be a serious clinical problem despite the availability of effective antivirals .',
  'Genital herpes simplex virus infection has a complex pathogenesis that has contributed to it becoming a serious worldwide problem .',
  'Recently , persistent and chronic HEV infections have been recognized as a serious clinical problem , especially in immunocompromised individuals .',
  'Genital herpes , an incurable viral disease that can have a devastating impact on affected patients , is a serious public health concern affecting one in four Americans .',
  'Finally , all physicians should realize that Herpes simplex infection in patients with AD can be a serious and sometimes life-threatening problem .',
  'The frequent occurrence of genital herpes continues to be a serious clinical problem .'],
 'hsv': ['Research results on the efficacy of sunblock sticks in avoiding or reducing Herpes labialis (HL) recurrences are contradictory and has shown mixed results, with some protection reported under experimental conditions that could not be replicated under natural conditions.',
  'Postherpetic itch has not commonly received attention as a complication of herpes zoster because pain predominates over itch in most patients with herpes zoster',
  'As opportunistic infections among human T-lymphotrophic virus type 1 ( HTLV-1 ) carriers and patients with adult T-cell leukemia/lymphoma ( ATL ) pose a serious problem , it is necessary to clarify their clinical characteristics and outcomes in these patients .',
  'Despite the availability of antiviral chemotherapy , herpes simplex virus type 1 ( HSV-1 ) and type 2 ( HSV-2 ) infections remain a severe global health problem .',
  'HSV infection is a serious problem due to : the increasing number of cases ; its ability to remain latent in the host and periodically cause recurrent infection ; and lack of effective treatment .',
  'Primary varicella infection remains a serious problem in immunocompromised patients .',
  'Ocular infection with HSV-1 continues to be a serious clinical problem despite the availability of effective antivirals .',
  'Genital herpes simplex virus infection has a complex pathogenesis that has contributed to it becoming a serious worldwide problem .',
  'Recently , persistent and chronic HEV infections have been recognized as a serious clinical problem , especially in immunocompromised individuals .',
  'Genital herpes , an incurable viral disease that can have a devastating impact on affected patients , is a serious public health concern affecting one in four Americans .',
  'Finally , all physicians should realize that Herpes simplex infection in patients with AD can be a serious and sometimes life-threatening problem .',
  'The frequent occurrence of genital herpes continues to be a serious clinical problem .'],
 'genital': ['Research results on the efficacy of sunblock sticks in avoiding or reducing Herpes labialis (HL) recurrences are contradictory and has shown mixed results, with some protection reported under experimental conditions that could not be replicated under natural conditions.',
  'Postherpetic itch has not commonly received attention as a complication of herpes zoster because pain predominates over itch in most patients with herpes zoster',
  'As opportunistic infections among human T-lymphotrophic virus type 1 ( HTLV-1 ) carriers and patients with adult T-cell leukemia/lymphoma ( ATL ) pose a serious problem , it is necessary to clarify their clinical characteristics and outcomes in these patients .',
  'Despite the availability of antiviral chemotherapy , herpes simplex virus type 1 ( HSV-1 ) and type 2 ( HSV-2 ) infections remain a severe global health problem .',
  'HSV infection is a serious problem due to : the increasing number of cases ; its ability to remain latent in the host and periodically cause recurrent infection ; and lack of effective treatment .',
  'Primary varicella infection remains a serious problem in immunocompromised patients .',
  'Ocular infection with HSV-1 continues to be a serious clinical problem despite the availability of effective antivirals .',
  'Genital herpes simplex virus infection has a complex pathogenesis that has contributed to it becoming a serious worldwide problem .',
  'Recently , persistent and chronic HEV infections have been recognized as a serious clinical problem , especially in immunocompromised individuals .',
  'Genital herpes , an incurable viral disease that can have a devastating impact on affected patients , is a serious public health concern affecting one in four Americans .',
  'Finally , all physicians should realize that Herpes simplex infection in patients with AD can be a serious and sometimes life-threatening problem .',
  'The frequent occurrence of genital herpes continues to be a serious clinical problem .'],
 'nausea': ['Nocebo nausea is a debilitating and prevalent side effect that can develop after conditioning occurs between cues present in the treatment context and the experience of nausea.',
  'Postoperative nausea and vomiting (PONV) are major complications after general anesthesia',
  'Gastric intolerance manifesting as nausea constitutes a demanding drawback of thiopurines , at times forcing treatment discontinuance .',
  'Chronic unexplained nausea and vomiting is a debilitating condition that dramatically decreases patient quality of life and creates diagnostic and treatment challenges for healthcare providers .',
  'Post-operative vomiting , especially in ambulatory surgical patients , remains a troublesome problem .',
  'Postoperative nausea and vomiting ( PONV ) remains a distressing and common problem after strabismus repair in particular in children .',
  'Postoperative nausea and vomiting continues to be a distressing problem despite the availability of new information .',
  'Postoperative nausea and vomiting ( PONV ) after laparoscopic cholecystectomy operations still continue to be a serious problem .',
  'Postoperative nausea and emesis , especially in ambulatory surgical patients , remains a troublesome problem .',
  'Nausea and vomiting caused by cytotoxic drugs have been a serious problem in anti-cancer therapy and prompted lots of scientists to find the mechanism and to develop antiemetics .',
  'Chemotherapy-induced nausea and vomiting ( CINV ) continue to be a distressing problem still reported by cancer patients , with negative consequences on quality of life ( QoL ) .',
  'Postoperative nausea and vomiting ( PONV ) remains a troublesome problem .',
  'In patients undergoing laparoscopic surgeries , postoperative nausea and vomiting ( PONV ) is a serious concern .',
  'Postoperative nausea and vomiting ( PONV ) is a distressing problem after strabismus surgery .',
  'Such retrospective exaggeration has apparently contributed to the widespread belief that vomiting following gastric bypass surgery is a serious problem .',
  'Intractable nausea and/or vomiting is a serious and significant clinical dilemma that may greatly detract from quality of life .',
  'Dyspeptic symptoms present a severe problem in gastrointestinal ( GI ) cancer patients .',
  'Postoperative nausea and vomiting ( PONV ) is a serious concern in patients undergoing laparoscopic cholecystectomy ( LC ) , with an incidence of 46 to 72 % .',
  'Chemotherapy-induced amenorrhea is a serious concern for women undergoing cancer therapy .',
  'Despite the availability of several antiemetics , clinical findings show that control of chemotherapy-induced nausea and vomiting ( CINV ) continues to be a serious concern for hematological patients , mainly for those receiving multiple-day ( MD ) and high-dose ( HD ) chemotherapy ( CT ) .',
  'Chemotherapy-induced nausea and vomiting ( CINV ) is a serious problem for cancer patients receiving chemotherapy .',
  'Intestinal mucositis induced by chemotherapy is a severe clinical problem in cancer patients that currently lack effective interventions .'],
 'vomiting': ['Nocebo nausea is a debilitating and prevalent side effect that can develop after conditioning occurs between cues present in the treatment context and the experience of nausea.',
  'Postoperative nausea and vomiting (PONV) are major complications after general anesthesia',
  'Gastric intolerance manifesting as nausea constitutes a demanding drawback of thiopurines , at times forcing treatment discontinuance .',
  'Chronic unexplained nausea and vomiting is a debilitating condition that dramatically decreases patient quality of life and creates diagnostic and treatment challenges for healthcare providers .',
  'Post-operative vomiting , especially in ambulatory surgical patients , remains a troublesome problem .',
  'Postoperative nausea and vomiting ( PONV ) remains a distressing and common problem after strabismus repair in particular in children .',
  'Postoperative nausea and vomiting continues to be a distressing problem despite the availability of new information .',
  'Postoperative nausea and vomiting ( PONV ) after laparoscopic cholecystectomy operations still continue to be a serious problem .',
  'Postoperative nausea and emesis , especially in ambulatory surgical patients , remains a troublesome problem .',
  'Nausea and vomiting caused by cytotoxic drugs have been a serious problem in anti-cancer therapy and prompted lots of scientists to find the mechanism and to develop antiemetics .',
  'Chemotherapy-induced nausea and vomiting ( CINV ) continue to be a distressing problem still reported by cancer patients , with negative consequences on quality of life ( QoL ) .',
  'Postoperative nausea and vomiting ( PONV ) remains a troublesome problem .',
  'In patients undergoing laparoscopic surgeries , postoperative nausea and vomiting ( PONV ) is a serious concern .',
  'Postoperative nausea and vomiting ( PONV ) is a distressing problem after strabismus surgery .',
  'Such retrospective exaggeration has apparently contributed to the widespread belief that vomiting following gastric bypass surgery is a serious problem .',
  'Intractable nausea and/or vomiting is a serious and significant clinical dilemma that may greatly detract from quality of life .',
  'Dyspeptic symptoms present a severe problem in gastrointestinal ( GI ) cancer patients .',
  'Postoperative nausea and vomiting ( PONV ) is a serious concern in patients undergoing laparoscopic cholecystectomy ( LC ) , with an incidence of 46 to 72 % .',
  'Chemotherapy-induced amenorrhea is a serious concern for women undergoing cancer therapy .',
  'Despite the availability of several antiemetics , clinical findings show that control of chemotherapy-induced nausea and vomiting ( CINV ) continues to be a serious concern for hematological patients , mainly for those receiving multiple-day ( MD ) and high-dose ( HD ) chemotherapy ( CT ) .',
  'Chemotherapy-induced nausea and vomiting ( CINV ) is a serious problem for cancer patients receiving chemotherapy .',
  'Intestinal mucositis induced by chemotherapy is a severe clinical problem in cancer patients that currently lack effective interventions .'],
 'chemotherapy': ['Nocebo nausea is a debilitating and prevalent side effect that can develop after conditioning occurs between cues present in the treatment context and the experience of nausea.',
  'Postoperative nausea and vomiting (PONV) are major complications after general anesthesia',
  'A major problem with treating patients with cancer by traditional chemotherapeutic regimes is that their tumors often develop a multidrug resistant ( MDR ) phenotype and subsequently become insensitive to a range of different chemotoxic drugs .',
  'As a drawback of established drugs , like paclitaxel or the vinca alkaloids , the outcome of cancer chemotherapy is often affected by the emergence of the multidrug resistance phenotype .',
  'A major drawback of therapy with ATO is the development of APL cell resistance , the mechanisms of which are still not clear .',
  'Acquired or innate resistance to chemotherapy is a major drawback of cancer therapeutics , which is frequently seen in epithelial cancers .',
  'Nevertheless , a poor drug penetration is one key drawback of IP chemotherapy since peritoneal neoplasms are notoriously resistant to drug penetration .',
  'Gastric intolerance manifesting as nausea constitutes a demanding drawback of thiopurines , at times forcing treatment discontinuance .',
  'Emergence of resistance to chemotherapy is a serious clinical problem .',
  'Alterations in calcium homeostasis may also support resistance to apoptosis , which is a serious problem facing current chemotherapeutic treatments .',
  'Multidrug resistance is a serious problem in current chemotherapy .',
  'Thirty-four previously untreated patients with oat cell carcinoma of the lung were treated with a myelotoxic combination of cyclophosphamide , adriamycin , methotrexate , CCNU , and Corynebacterium parvum ( regimen A ) every 4 weeks , interspersed with a non-myelotoxic combination including bleomycin , vincristine , dehydroemetine , and Corynebacterium parvum ( regimen B ) weekly the other 3 weeks or when hematologic toxicity prohibited administration of regimen A. Hematologic toxicity was frequent but was never a serious problem except in two cases of profound leukopenia in which fatal supervening infection occurred .',
  'Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases .',
  'However , little is known about the effects of GLA on leukemia resistant to chemotherapy , emerging as a serious clinical problem .',
  'The development of neutropenia in a patient undergoing therapy for cancer represents a serious medical problem that rapidly escalates if fever develops .',
  'The development of drug resistance and especially of multidrug resistance ( MDR ) is a serious problem during treatment of various malignant tumors .',
  'Multidrug resistance ( MDR ) is a severe problem in the treatment of cancer with overexpression of glycoprotein P ( Pgp , ABCB1 ) as a reason for chemotherapy failure .',
  'Chronic unexplained nausea and vomiting is a debilitating condition that dramatically decreases patient quality of life and creates diagnostic and treatment challenges for healthcare providers .',
  'Post-operative vomiting , especially in ambulatory surgical patients , remains a troublesome problem .',
  'Postoperative nausea and vomiting ( PONV ) remains a distressing and common problem after strabismus repair in particular in children .',
  'Resistance of progressive cancers against chemotherapy is a serious clinical problem .',
  'Postoperative nausea and vomiting continues to be a distressing problem despite the availability of new information .',
  'Postoperative nausea and vomiting ( PONV ) after laparoscopic cholecystectomy operations still continue to be a serious problem .',
  'The development of resistance poses a serious problem in the therapy of cancer due to the necessity of a multiple-drug and unlimited treatment of affected patients .',
  'Multidrug resistance ( MDR ) is a serious problem faced in the treatment of malignant tumors .',
  "Intensive chemotherapy ( CHT ) in AIDS-related non-Hodgkin 's lymphoma ( AIDS-NHL patients ) is a vexing problem .",
  'Resistance to chemotherapy drugs is a serious therapeutic problem and its underlying molecular mechanisms are complex .',
  'Resistance to chemotherapy remains a serious problem inhibiting the successful treatment of advanced esophageal cancer .',
  'These studies may indicate that alpha-tocopherol succinate can be used as an adjunct in cancer chemotherapy , where neutropenia is a serious problem with threatening infectious complications .',
  'Postoperative nausea and emesis , especially in ambulatory surgical patients , remains a troublesome problem .',
  'Nausea and vomiting caused by cytotoxic drugs have been a serious problem in anti-cancer therapy and prompted lots of scientists to find the mechanism and to develop antiemetics .',
  'The occurrence of chemoresistance is a serious problem in the treatment of cancer , urging the need for second and third-line treatment options that rely on different cell death pathways to overcome previously acquired resistance mechanisms .',
  'Drug resistance continues to be a serious problem in cancer therapy .',
  'Acquired resistance to therapeutic drugs is a serious problem for patients with cancer receiving systemic treatment .',
  'However , multidrug resistance ( MDR ) becomes a severe problem after long-term administration of chemotherapy drugs .',
  'Chemotherapy-induced nausea and vomiting ( CINV ) continue to be a distressing problem still reported by cancer patients , with negative consequences on quality of life ( QoL ) .',
  'The development of multidrug resistance ( MDR ) in breast cancer patients is a serious therapeutic problem .',
  'However , emergence of imatinib-resistance has put up a serious problem that requires novel treatment methods .',
  'Tumor cell resistance to fluoropyrimidines and other inhibitors of thymidylate synthase ( TS ) is a serious problem often associated with increased intracellular TS .',
  'Chemotherapy-induced neutropenia , the depth and length of which are correlated to the risk of febrile neutropenia ( FN ) and neutropenia sepsis , remains a serious problem in medical oncology .',
  'Multidrug resistance ( MDR ) to anticancer drugs is a serious health problem that in many cases leads to cancer treatment failure .',
  'Multidrug resistance ( MDR ) of hepatocellular carcinoma is a serious problem .',
  'Drug resistance in anticancer treatment is a serious problem .',
  'Postoperative nausea and vomiting ( PONV ) remains a troublesome problem .',
  'In patients undergoing laparoscopic surgeries , postoperative nausea and vomiting ( PONV ) is a serious concern .',
  'Infection remains a serious problem in the management of children with leukemia .',
  'Drug resistance remains a serious problem in leukemia therapy .',
  'Infections continue to be a serious problem for severely neutropenic oncology and haematopoietic progenitor cell ( HPC ) transplant patients .',
  'Intolerable malodor emanating from ulcerated tumors as a result of anaerobic infection is a serious problem in the management of advanced and recurrent breast cancer .',
  'Multidrug resistance ( MDR ) represents a serious problem in cancer treatment .',
  'Postoperative nausea and vomiting ( PONV ) is a distressing problem after strabismus surgery .',
  'Such retrospective exaggeration has apparently contributed to the widespread belief that vomiting following gastric bypass surgery is a serious problem .',
  'Drug-drug interactions mediated by transporters are a serious clinical concern hence a tremendous amount of work has been done on the characterization of the transporter-mediated proteins in humans and animals .',
  'Multidrug resistance mediated by ATP binding cassette ( ABC ) transporters such as P-glycoprotein ( P-gp ) represents a serious problem for the development of effective anticancer drugs .',
  'Drug resistance remains a severe problem in most chemotherapy regimes .',
  'Resistance against apoptosis-inducing anti-cancer drugs remains a severe problem in therapy .',
  'Multidrug resistance ( MDR ) is a serious problem that hampers the success of cancer pharmacotherapy .',
  'Resistance of cancer cells to chemotherapeutics and emerging targeted drugs is a devastating problem in the treatment of cancer patients .',
  'This finding indicate that multidrug resistance does not represent a serious problem among NTS serotypes collected from the our medical center as monitored over a period of 7 years .',
  'Multidrug resistance ( MDR ) presents a serious problem in cancer chemotherapy .',
  'A DPD-deficient phenotype among cancer patients , which has posed a serious problem in 5FU-based chemotherapy , was reported to be in part ascribed to germline mutations in dihydropyrimidine dehydrogenase ( DPYD ) gene .',
  'However , initial resistance to CDDP is a serious problem in treating cancers .',
  'Multidrug resistance of cancer cells constitutes a serious problem in chemotherapy and a challenging issue in the discovery of new cytotoxic drugs .',
  'Intractable nausea and/or vomiting is a serious and significant clinical dilemma that may greatly detract from quality of life .',
  'The acquisition of multidrug resistance poses a serious problem in chemotherapy , and new types of transporters have been actively sought to overcome it .',
  'E. coli pyomyositis has emerged as a serious problem among our patients with hematologic malignancy .',
  'Multidrug resistance , mediated by the P-glycoprotein 170 transport pump , is a serious problem in multiple myeloma .',
  'The multi-drug resistance ( MDR ) of cancer cells , including 5-fluorouracil ( 5-FU ) resistance , has been a serious problem for patients with cancer .',
  'Multidrug resistance presents a serious problem in cancer chemotherapy .',
  'ATP-driven pumping of a variety of drugs out of cells by the human P-glycoprotein poses a serious problem to medical therapy .',
  'Infection in those treated by CAPD was a serious problem and may be exacerbated by aggressive chemotherapy .',
  'Infectious complications that arise during the treatment of children with acute leukemia with chemotherapeutic agents at high doses represent a serious problem in oncohematology .',
  'Drug resistance , in particular multidrug resistance , is a serious problem that impedes the effectiveness of chemotherapy .',
  'Dyspeptic symptoms present a severe problem in gastrointestinal ( GI ) cancer patients .',
  'Postoperative nausea and vomiting ( PONV ) is a serious concern in patients undergoing laparoscopic cholecystectomy ( LC ) , with an incidence of 46 to 72 % .',
  'Multidrug resistance , especially multidrug efflux mechanisms that extrude structurally unrelated cytotoxic compounds from the cell by multidrug transporters , is a serious problem and one of the main reasons for the failure of therapeutic treatment of infections by pathogenic microorganisms as well as of cancer cells .',
  'Multidrug resistance is a serious problem in successful cancer chemotherapy .',
  'Multidrug resistance ( MDR ) is a serious medical problem and presents a major challenge to the treatment of disease and the development of novel therapeutics .',
  'Chemotherapy-induced amenorrhea is a serious concern for women undergoing cancer therapy .',
  'Understanding fluconazole resistance is important as it emerged as a serious clinical problem for this CYP51 , sterol 14alpha-demethylase , inhibitor .',
  'Resistance to current chemotherapeutic or radiation-based cancer treatment strategies is a serious concern .',
  'Gemcitabine is an important chemotherapeutic agent that has been approved for the treatment of numerous human solid tumors , including HIPC , whereas the gemcitabine resistance has become a serious problem in clinical chemotherapy .',
  'Despite the availability of several antiemetics , clinical findings show that control of chemotherapy-induced nausea and vomiting ( CINV ) continues to be a serious concern for hematological patients , mainly for those receiving multiple-day ( MD ) and high-dose ( HD ) chemotherapy ( CT ) .',
  'The multidrug resistance ( MDR ) of malignant tumor is a troublesome problem in the chemotherapy .',
  'In cancer therapy , drug resistance is a severe problem , reducing therapeutic effect of drugs and adding to patient suffering .',
  'Acquisition of resistance to anticancer agents is a serious problem for cancer chemotherapy .',
  'Chemotherapy-induced nausea and vomiting ( CINV ) is a serious problem for cancer patients receiving chemotherapy .',
  'Multidrug resistance of cancer cells and pathogens is a serious clinical problem .',
  'Primary and secondary resistance to imatinib , a selective receptor tyrosine kinase inhibitor ( TKI ) , is a serious clinical problem in the control of advanced gastrointestinal stromal tumors ( GIST ) .',
  'Resistance to chemotherapy remains a serious problem in the successful treatment of gastric and esophageal cancers .',
  'Multidrug resistance of cancer cells is a serious problem in the treatment of tumors and is the leading cause of the frequent failure of chemotherapy .',
  'Multidrug resistance ( MDR ) is a serious problem in chemotherapy and is one of the main reasons for a poor outcome of gastric cancer .',
  'Although infection remains a serious problem in leukemia patients , considerable progress has been made .',
  'Intestinal mucositis induced by chemotherapy is a severe clinical problem in cancer patients that currently lack effective interventions .',
  'Immmunosuppression and infectious disease in cancer patients receiving chemotherapy is a serious problem .',
  'Bacterial infections in patients with hematologic malignancies still represent a severe and life-treating problem .',
  'However , the development of chemotherapy resistance is a severe clinical problem for the successful treatment of this and other cancers .',
  'However , cell-type specific and patient-to-patient variability in response to SERMs ( from suppression to stimulation of cancer growth ) , as well as frequent emergence of drug resistance , represents a serious problem .',
  'Multidrug resistance is a severe clinical problem in the chemotherapy of malignant disease .',
  'Multidrug resistance ( MDR ) presents a serious problem in cancer chemotherapy .'],
 'asthma': ['Little work has been done on identifying the impact of educational materials developed by immigrant patients themselves, along with their caregivers and health professionals in terms of inhaler use technique.',
  'Exacerbations drive the burden of asthma and lead to significant morbidity and consumption of health care resources.',
  'Aspirin-exacerbated respiratory disease (AERD) is a disorder of nasal polyposis, asthma, and hypersensitivity respiratory reactions when on systemic cyclooxygenase 1 blockade',
  'The rate of asthma in the pediatric population has risen over the last two decades and is now considered to be the most common serious chronic disease in children and adolescents as well as a serious public health concern .',
  'Asthma constitutes a serious public health problem in many regions of the world , including the city of Salvador , State of Bahia-Brazil .',
  'Asthma is a severe problem among inner city children , and recent evidence suggests that both allergen exposure and lifestyle can impact the disease early in childhood .',
  'Asthma is a serious global health problem affecting all age groups , with global prevalence .',
  'Asthma is a serious health problem throughout the world .',
  'Asthma is a serious world health problem characterised by a chronic inflammatory disorder of the airways .',
  'Bronchial asthma is one of the most common chronic diseases in the world and has become a serious public health problem .',
  'Asthma remains a severe health problem since current therapies are directed to suppressing , rather than preventing or reversing , the primary disease process .',
  'Childhood asthma is believed to be a serious problem in Cape Town , South Africa .',
  'Asthma is a serious global health problem that affects people of all ages .',
  'Recurrent wheezing in children represents a severe public health concern .',
  'Asthma is a serious global health problem with rising prevalence and treatment costs .',
  'We focus here on childhood asthma as an example of a serious public health problem that has been associated with low income , minority status , and characteristics of the home environment .',
  'Fatal asthma is rare but constitutes a serious public health problem on account of the raised prevalence of the disease .',
  'Asthma is a serious problem for low-income preteens living in disadvantaged communities .',
  'The findings demonstrate smoking as a serious social problem associated with allergic diseases , and a habit that differs between place of residence and work environment .',
  'Asthma is a serious health problem worldwide , particularly in industrialized countries .',
  'Asthma is a serious health problem , with both mortality and severity increasing in developed countries ( 55 - 57 ) .',
  'A life-threatening asthma attack is still of major concern .',
  'Asthma is a serious global health problem .',
  'Severe eosinophilic asthma poses a serious health and economic problem , so new therapy approaches have been developed to control it , including biological drugs such as benralizumab , which is a monoclonal antibody that binds to IL-5 receptor alpha subunit and depletes peripheral blood eosinophils rapidly .',
  'Asthma is a serious health problem around the world , and affects approximately 10 - 15 % of children and 5 - 10 % of adults .',
  'Generally estimated to be around 10%-46 % , noncompliance with asthma therapy is a serious problem and studies have shown that compliance with the mainstay of asthma treatment , inhaled corticosteroids , is low .',
  'Asthma is a serious global health problem with an estimated 300 million affected individuals .',
  'Asthma and allergies prevalence increased in recent decades , being a serious global health problem .',
  'Asthma is a serious global health problem .',
  'Asthma , a chronic inflammatory condition defined by episodic shortness of breath with expiratory wheezing and cough , is a serious health concern affecting more than 250 million persons .',
  "Asthma as a serious public health problem worldwide exerts a serious load on children 's health-related quality of life ( HRQOL ) and their families .",
  'Asthma is also a serious economic concern in primary health care worldwide .',
  'Asthma is a serious national health care problem with a direct impact on health care costs .',
  'Asthma is a serious medical problem in pregnancy and is often associated with stress , anger and poor quality of life .',
  'General and ethnic media and a Speakers Bureau were used to raise public awareness of asthma as a serious but controllable health problem .',
  'Under and overtreatment of asthma may be a serious problem especially in young children , but the evidence is scarce and no longitudinal data are available .',
  'Asthma is a serious global health problem affecting all age groups , with global prevalence .',
  'Asthma in Puerto Rico is a serious Public Health Problem .',
  'Bronchial asthma ( BA ) is a serious problem .',
  "Asthma has a major impact on patients ' lives , and severe asthma is a serious health problem .",
  'Asthma is one of the most common disorders of respiratory tract , management of which still remains as a serious health problem .',
  'Asthma is a serious health problem in blacks and is not explained by differences in demographics , severity , or other health conditions .',
  'Asthma is a serious public health problem in China .',
  "Pediatric asthma is a serious public health problem in Chicago and has been designated a high priority concern by residents of Chicago 's Humboldt Park , a diverse community area with a large number of Puerto Rican , African American , and Mexican American families .",
  'The epidemiological distribution of asthma of Li nationality in Hainan has been determined . And asthma remains a severe problem locally .',
  'Asthmatic death in the elderly is a serious problem worldwide .',
  'Asthma is a serious global health problem , severely affecting the lives of sufferers and their families .',
  'Asthma is a serious health and social problem , also in Poland .',
  'Asthma is a chronic airway disorder that is a serious public health problem in many countries .',
  'Asthma is a serious health problem that involves not only the respiratory system but also the central nervous system .',
  'Asthma , a serious health problem worldwide , is becoming more common .',
  'Asthma is a chronic airway disease that is based on an inflammatory process and a serious health problem around the world .',
  'Asthma is a serious global health problem .',
  'Recognizing the significance of asthma as a serious public health problem , Healthy People 2000 has targeted improvements in asthma care as one of its objectives and the National Heart , Lung , and Blood Institute has research and education programs to improve the health of our children with asthma .',
  'Asthma is a serious health problem and during the last decade various experimental models of asthma have been developed to study the pathogenesis of this disease .',
  'Asthma remains a troubling health problem despite the availability of effective treatment .',
  'Asthma is a serious , growing problem worldwide .',
  'Cognitive impairments are common in asthma , which is a serious global health problem characterized by chronic airway inflammation .',
  'Severe , steroid-resistant asthma ( SSRA ) is a serious clinical problem in asthma management .',
  'Bronchial asthma is a serious global health problem .',
  'Asthma represents a serious global health problem .',
  'Poorly controlled asthma imposes a considerable burden and is a serious public health problem in the developing world .',
  'Recently , Asian dust ( AD ) has become a serious health problem and several studies have clearly proven that AD can aggravate asthma .',
  'Bronchial asthma is a serious global health problem .',
  'Reflux-induced asthma remains a vexing problem in the absence of either medical therapy or proven efficacy of a reliable mechanism of prospectively identifying affected patients .',
  'Asthma is a serious public health problem .',
  'Morbidity and mortality by bronchial asthma continues to be a serious public health problem all over the world .',
  'Asthma is a serious health problem causing significant mortality and morbidity globally .',
  'Asthma is a serious global health problem that has steadily increased in prevalence during the past two decades .',
  'Asthma is a serious global health problem .',
  'Asthma is the most common chronic disease in children and adolescents and a serious global health problem , thus severely affecting the health related quality of life ( HRQL ) .',
  'Asthma represents a serious health problem particularly for inner city children , and recent studies have identified that cockroach allergens trigger many of these asthmatic attacks .',
  'Asthma is a serious public health concern globally with an estimated incidence over 300 million .',
  'Asthma is a serious global health problem affecting nearly 100 million people worldwide .',
  'Despite remarkable advances in diagnosis and long-term management , asthma remains a serious public health concern .',
  'Asthma is a serious and vexing problem for many children and their families .',
  'Management of asthma in chronically affected patients is a serious health problem .',
  'Asthma is a serious global health problem affecting all age groups , with global prevalence .',
  'Asthma is a serious public health concern , disproportionately affecting urban , minority populations .',
  'Recurrent airway obstruction ( RAO ) represents a serious health problem and is traditionally classified as an allergic disease , where contact with an antigen can induce clinical airway inflammation , bronchial hyper-responsiveness and reversible airway obstruction .',
  'Asthma is a serious health problem for First Nations and Inuit children .',
  'Asthma is a chronic airways inflammatory disease considered as a serious public health problem .',
  'Childhood asthma is highly prevalent in Pelotas , and it is a serious public health problem .',
  'Asthma is a chronic immune disease that has become a serious public health problem .',
  'In our Western European population of inner city children with asthma , poor adherence to ICS was a serious problem , and even somewhat more so in ethnic minorities .',
  'Smoking among people who have asthma may be a serious health problem .',
  'Asthma is a multifactorial disease and a serious public health problem .',
  'Asthma is a serious global health problem characterised by airway inflammation , airway epithelial wall shedding , enhanced mucus production , increased IgE levels and airway hyperresponsiveness .'],
 'eating': ['Underweight eating disorders (EDs) are notoriously difficult to treat, although a growing evidence base suggests that outpatient cognitive behaviour therapy for EDs (CBT-ED) can be effective for a large proportion of individuals.',
  'Previous research suggests that computerized interpretation bias modification (IBM) techniques may be useful for modifying thoughts and behaviours relevant to eating pathology; however, little is known about the utility of IBM for decreasing specific eating disorder (ED) symptoms (e.g. bulimia, drive for thinness).',
  'Many adolescents and young adults, especially young females, suffer from eating disorders or problematic nutrition behavior',
  'Binge eating is a serious behavior problem exhibited by individuals diagnosed with binge eating disorder and bulimia nervosa .',
  'Eating disorders are a serious concern in clients health and a challenge to oral health professionals .',
  'Shoplifting is a serious problem among patients with eating disorders . For more than a decade , we have treated many patients with eating disorders incarcerated in Hachioji Medical Prison only for repeated shoplifting .',
  'The current study examined whether variations in patient weight and eating-disorder behavior frequency influenced the recognition of bulimia nervosa ( BN ) and the perception that it is a serious mental health concern .',
  "Eating disorders such as anorexia nervosa , bulimia nervosa , and binge-eating disorder are a serious concern in women 's oral health and a clinical challenge to dental professionals .",
  'Lack of participation in follow-ups is thought to be a serious bias in outcome research on eating disorders ; however , little systematic knowledge exists about the problem .',
  'Body dysmorphic disorder : A serious concern for our young generation .',
  'Bulimia nervosa represents a serious public health problem in the United States .',
  'Juvenile Anorexia Nervosa ( AN ) is a severe problem both in terms of presenting symptomatology and its tendency toward chronicity .',
  'Eating disorders among the adolescent population are a serious health problem .',
  'Drop-out from treatment is a serious problem in eating disorders which remains poorly understood .',
  'Feeding and eating disorders represent a serious problem especially in young population .',
  "I argue that there is no great mystery to how bulimia has become such a serious problem for today 's women .",
  "Eating disorders are a serious debilitating health problem , causing impairments in physical and psychosocial functioning and significantly affecting sufferers ' quality of life .",
  'Shoplifting , prevalent in patients diagnosed with bulimia nervosa ( BN ) , is a serious behavioral problem in eating disorder ( ED ) patients .',
  'A serious problem faced by clinicians treating anorexia nervosa is the egosyntonic nature of the illness , wherein individuals with anorexia nervosa value their disorder , thereby hindering motivation for recovery and engagement with treatment .',
  'Anorexia nervosa , bulimia nervosa , binge-eating disorder are characterized by a serious disturbance in eating , such as restriction of intake or bingeing , as well as distress or excessive concern about body shape or body weight .',
  'Subsequently , eating disorders have become a serious concern for medical and dental professionals .',
  'Eating disorders : A serious problem of mental health seeks solution .',
  'The treatment of Body Dysmorphic Disorder ( BDD ) has received little empirical attention despite evidence that BDD is a debilitating mental health problem .',
  'Anorexia nervosa is a serious health problem worldwide .',
  'The strong response indicates that eating disorders are a serious concern in primary practice .',
  'We argue that , because there is scant research into men with eating disorders and men strive to conceal this health problem , nurses should be equipped with information that will support earlier detection of EDs among men and boys before they manifest as a serious health problem .'],
 'nervosa': ['Underweight eating disorders (EDs) are notoriously difficult to treat, although a growing evidence base suggests that outpatient cognitive behaviour therapy for EDs (CBT-ED) can be effective for a large proportion of individuals.',
  'Previous research suggests that computerized interpretation bias modification (IBM) techniques may be useful for modifying thoughts and behaviours relevant to eating pathology; however, little is known about the utility of IBM for decreasing specific eating disorder (ED) symptoms (e.g. bulimia, drive for thinness).',
  'Many adolescents and young adults, especially young females, suffer from eating disorders or problematic nutrition behavior',
  'Binge eating is a serious behavior problem exhibited by individuals diagnosed with binge eating disorder and bulimia nervosa .',
  'Eating disorders are a serious concern in clients health and a challenge to oral health professionals .',
  'Shoplifting is a serious problem among patients with eating disorders . For more than a decade , we have treated many patients with eating disorders incarcerated in Hachioji Medical Prison only for repeated shoplifting .',
  'The current study examined whether variations in patient weight and eating-disorder behavior frequency influenced the recognition of bulimia nervosa ( BN ) and the perception that it is a serious mental health concern .',
  "Eating disorders such as anorexia nervosa , bulimia nervosa , and binge-eating disorder are a serious concern in women 's oral health and a clinical challenge to dental professionals .",
  'Lack of participation in follow-ups is thought to be a serious bias in outcome research on eating disorders ; however , little systematic knowledge exists about the problem .',
  'Body dysmorphic disorder : A serious concern for our young generation .',
  'Bulimia nervosa represents a serious public health problem in the United States .',
  'Juvenile Anorexia Nervosa ( AN ) is a severe problem both in terms of presenting symptomatology and its tendency toward chronicity .',
  'Eating disorders among the adolescent population are a serious health problem .',
  'Drop-out from treatment is a serious problem in eating disorders which remains poorly understood .',
  'Feeding and eating disorders represent a serious problem especially in young population .',
  "I argue that there is no great mystery to how bulimia has become such a serious problem for today 's women .",
  "Eating disorders are a serious debilitating health problem , causing impairments in physical and psychosocial functioning and significantly affecting sufferers ' quality of life .",
  'Shoplifting , prevalent in patients diagnosed with bulimia nervosa ( BN ) , is a serious behavioral problem in eating disorder ( ED ) patients .',
  'A serious problem faced by clinicians treating anorexia nervosa is the egosyntonic nature of the illness , wherein individuals with anorexia nervosa value their disorder , thereby hindering motivation for recovery and engagement with treatment .',
  'Anorexia nervosa , bulimia nervosa , binge-eating disorder are characterized by a serious disturbance in eating , such as restriction of intake or bingeing , as well as distress or excessive concern about body shape or body weight .',
  'Subsequently , eating disorders have become a serious concern for medical and dental professionals .',
  'Eating disorders : A serious problem of mental health seeks solution .',
  'The treatment of Body Dysmorphic Disorder ( BDD ) has received little empirical attention despite evidence that BDD is a debilitating mental health problem .',
  'Anorexia nervosa is a serious health problem worldwide .',
  'The strong response indicates that eating disorders are a serious concern in primary practice .',
  'We argue that , because there is scant research into men with eating disorders and men strive to conceal this health problem , nurses should be equipped with information that will support earlier detection of EDs among men and boys before they manifest as a serious health problem .'],
 'bulimia': ['Underweight eating disorders (EDs) are notoriously difficult to treat, although a growing evidence base suggests that outpatient cognitive behaviour therapy for EDs (CBT-ED) can be effective for a large proportion of individuals.',
  'Previous research suggests that computerized interpretation bias modification (IBM) techniques may be useful for modifying thoughts and behaviours relevant to eating pathology; however, little is known about the utility of IBM for decreasing specific eating disorder (ED) symptoms (e.g. bulimia, drive for thinness).',
  'Many adolescents and young adults, especially young females, suffer from eating disorders or problematic nutrition behavior',
  'Binge eating is a serious behavior problem exhibited by individuals diagnosed with binge eating disorder and bulimia nervosa .',
  'Eating disorders are a serious concern in clients health and a challenge to oral health professionals .',
  'Shoplifting is a serious problem among patients with eating disorders . For more than a decade , we have treated many patients with eating disorders incarcerated in Hachioji Medical Prison only for repeated shoplifting .',
  'The current study examined whether variations in patient weight and eating-disorder behavior frequency influenced the recognition of bulimia nervosa ( BN ) and the perception that it is a serious mental health concern .',
  "Eating disorders such as anorexia nervosa , bulimia nervosa , and binge-eating disorder are a serious concern in women 's oral health and a clinical challenge to dental professionals .",
  'Lack of participation in follow-ups is thought to be a serious bias in outcome research on eating disorders ; however , little systematic knowledge exists about the problem .',
  'Body dysmorphic disorder : A serious concern for our young generation .',
  'Bulimia nervosa represents a serious public health problem in the United States .',
  'Juvenile Anorexia Nervosa ( AN ) is a severe problem both in terms of presenting symptomatology and its tendency toward chronicity .',
  'Eating disorders among the adolescent population are a serious health problem .',
  'Drop-out from treatment is a serious problem in eating disorders which remains poorly understood .',
  'Feeding and eating disorders represent a serious problem especially in young population .',
  "I argue that there is no great mystery to how bulimia has become such a serious problem for today 's women .",
  "Eating disorders are a serious debilitating health problem , causing impairments in physical and psychosocial functioning and significantly affecting sufferers ' quality of life .",
  'Shoplifting , prevalent in patients diagnosed with bulimia nervosa ( BN ) , is a serious behavioral problem in eating disorder ( ED ) patients .',
  'A serious problem faced by clinicians treating anorexia nervosa is the egosyntonic nature of the illness , wherein individuals with anorexia nervosa value their disorder , thereby hindering motivation for recovery and engagement with treatment .',
  'Anorexia nervosa , bulimia nervosa , binge-eating disorder are characterized by a serious disturbance in eating , such as restriction of intake or bingeing , as well as distress or excessive concern about body shape or body weight .',
  'Subsequently , eating disorders have become a serious concern for medical and dental professionals .',
  'Eating disorders : A serious problem of mental health seeks solution .',
  'The treatment of Body Dysmorphic Disorder ( BDD ) has received little empirical attention despite evidence that BDD is a debilitating mental health problem .',
  'Anorexia nervosa is a serious health problem worldwide .',
  'The strong response indicates that eating disorders are a serious concern in primary practice .',
  'We argue that , because there is scant research into men with eating disorders and men strive to conceal this health problem , nurses should be equipped with information that will support earlier detection of EDs among men and boys before they manifest as a serious health problem .'],
 'anorexia': ['Underweight eating disorders (EDs) are notoriously difficult to treat, although a growing evidence base suggests that outpatient cognitive behaviour therapy for EDs (CBT-ED) can be effective for a large proportion of individuals.',
  'Previous research suggests that computerized interpretation bias modification (IBM) techniques may be useful for modifying thoughts and behaviours relevant to eating pathology; however, little is known about the utility of IBM for decreasing specific eating disorder (ED) symptoms (e.g. bulimia, drive for thinness).',
  'Many adolescents and young adults, especially young females, suffer from eating disorders or problematic nutrition behavior',
  'Binge eating is a serious behavior problem exhibited by individuals diagnosed with binge eating disorder and bulimia nervosa .',
  'Eating disorders are a serious concern in clients health and a challenge to oral health professionals .',
  'Shoplifting is a serious problem among patients with eating disorders . For more than a decade , we have treated many patients with eating disorders incarcerated in Hachioji Medical Prison only for repeated shoplifting .',
  'The current study examined whether variations in patient weight and eating-disorder behavior frequency influenced the recognition of bulimia nervosa ( BN ) and the perception that it is a serious mental health concern .',
  "Eating disorders such as anorexia nervosa , bulimia nervosa , and binge-eating disorder are a serious concern in women 's oral health and a clinical challenge to dental professionals .",
  'Lack of participation in follow-ups is thought to be a serious bias in outcome research on eating disorders ; however , little systematic knowledge exists about the problem .',
  'Body dysmorphic disorder : A serious concern for our young generation .',
  'Bulimia nervosa represents a serious public health problem in the United States .',
  'Juvenile Anorexia Nervosa ( AN ) is a severe problem both in terms of presenting symptomatology and its tendency toward chronicity .',
  'Eating disorders among the adolescent population are a serious health problem .',
  'Drop-out from treatment is a serious problem in eating disorders which remains poorly understood .',
  'Feeding and eating disorders represent a serious problem especially in young population .',
  "I argue that there is no great mystery to how bulimia has become such a serious problem for today 's women .",
  "Eating disorders are a serious debilitating health problem , causing impairments in physical and psychosocial functioning and significantly affecting sufferers ' quality of life .",
  'Shoplifting , prevalent in patients diagnosed with bulimia nervosa ( BN ) , is a serious behavioral problem in eating disorder ( ED ) patients .',
  'A serious problem faced by clinicians treating anorexia nervosa is the egosyntonic nature of the illness , wherein individuals with anorexia nervosa value their disorder , thereby hindering motivation for recovery and engagement with treatment .',
  'Anorexia nervosa , bulimia nervosa , binge-eating disorder are characterized by a serious disturbance in eating , such as restriction of intake or bingeing , as well as distress or excessive concern about body shape or body weight .',
  'Subsequently , eating disorders have become a serious concern for medical and dental professionals .',
  'Eating disorders : A serious problem of mental health seeks solution .',
  'The treatment of Body Dysmorphic Disorder ( BDD ) has received little empirical attention despite evidence that BDD is a debilitating mental health problem .',
  'Anorexia nervosa is a serious health problem worldwide .',
  'The strong response indicates that eating disorders are a serious concern in primary practice .',
  'We argue that , because there is scant research into men with eating disorders and men strive to conceal this health problem , nurses should be equipped with information that will support earlier detection of EDs among men and boys before they manifest as a serious health problem .'],
 'disorders': ['Underweight eating disorders (EDs) are notoriously difficult to treat, although a growing evidence base suggests that outpatient cognitive behaviour therapy for EDs (CBT-ED) can be effective for a large proportion of individuals.',
  'Previous research suggests that computerized interpretation bias modification (IBM) techniques may be useful for modifying thoughts and behaviours relevant to eating pathology; however, little is known about the utility of IBM for decreasing specific eating disorder (ED) symptoms (e.g. bulimia, drive for thinness).',
  'Many adolescents and young adults, especially young females, suffer from eating disorders or problematic nutrition behavior',
  'Binge eating is a serious behavior problem exhibited by individuals diagnosed with binge eating disorder and bulimia nervosa .',
  'Eating disorders are a serious concern in clients health and a challenge to oral health professionals .',
  'Shoplifting is a serious problem among patients with eating disorders . For more than a decade , we have treated many patients with eating disorders incarcerated in Hachioji Medical Prison only for repeated shoplifting .',
  'The current study examined whether variations in patient weight and eating-disorder behavior frequency influenced the recognition of bulimia nervosa ( BN ) and the perception that it is a serious mental health concern .',
  "Eating disorders such as anorexia nervosa , bulimia nervosa , and binge-eating disorder are a serious concern in women 's oral health and a clinical challenge to dental professionals .",
  'Lack of participation in follow-ups is thought to be a serious bias in outcome research on eating disorders ; however , little systematic knowledge exists about the problem .',
  'Body dysmorphic disorder : A serious concern for our young generation .',
  'Bulimia nervosa represents a serious public health problem in the United States .',
  'Juvenile Anorexia Nervosa ( AN ) is a severe problem both in terms of presenting symptomatology and its tendency toward chronicity .',
  'Eating disorders among the adolescent population are a serious health problem .',
  'Drop-out from treatment is a serious problem in eating disorders which remains poorly understood .',
  'Feeding and eating disorders represent a serious problem especially in young population .',
  "I argue that there is no great mystery to how bulimia has become such a serious problem for today 's women .",
  "Eating disorders are a serious debilitating health problem , causing impairments in physical and psychosocial functioning and significantly affecting sufferers ' quality of life .",
  'Shoplifting , prevalent in patients diagnosed with bulimia nervosa ( BN ) , is a serious behavioral problem in eating disorder ( ED ) patients .',
  'A serious problem faced by clinicians treating anorexia nervosa is the egosyntonic nature of the illness , wherein individuals with anorexia nervosa value their disorder , thereby hindering motivation for recovery and engagement with treatment .',
  'Anorexia nervosa , bulimia nervosa , binge-eating disorder are characterized by a serious disturbance in eating , such as restriction of intake or bingeing , as well as distress or excessive concern about body shape or body weight .',
  'Subsequently , eating disorders have become a serious concern for medical and dental professionals .',
  'Eating disorders : A serious problem of mental health seeks solution .',
  'The treatment of Body Dysmorphic Disorder ( BDD ) has received little empirical attention despite evidence that BDD is a debilitating mental health problem .',
  'Anorexia nervosa is a serious health problem worldwide .',
  'The strong response indicates that eating disorders are a serious concern in primary practice .',
  'We argue that , because there is scant research into men with eating disorders and men strive to conceal this health problem , nurses should be equipped with information that will support earlier detection of EDs among men and boys before they manifest as a serious health problem .'],
 'medication': ['There are few studies of community pharmacy footfall and activity in the existing literature, especially by direct observation.',
  'Low levels of adherence to medication prescribed to treat and manage chronic disease may lead to maladaptive health outcomes.',
  'Medication non-adherence is a major contributor to poor outcomes in diabetes',
  'One particular problem with prescribing opioids to the elderly and long term care residents is that opioid safety and efficacy have not been well studied in these populations , and it may be difficult to predict how these patients will respond to opioid treatment .',
  'A drawback of the pharmacological challenge method is that individual differences in baseline arousal and outcome expectancy can lead to different subjective and physiological drug responses .',
  'Under-reporting is a major drawback of a voluntary adverse drug reaction reporting system in pharmacovigilance .',
  'Teaspoonful dosage , a serious problem .',
  'Potentially inappropriate medication use is a serious quality concern , especially when it occurs in more vulnerable older adults or for extended durations .',
  "Medication nonadherence is a vexing problem in health care necessitating patients and health professionals ' efforts to prevent , minimize , or reverse it .",
  'Misuse of prescription medications is a serious problem largely due to lack of information .',
  'Drug shortages in developed countries pose a serious public health problem and have far-reaching implications for healthcare providers and their patients .',
  'Medication errors are a serious and costly problem .',
  'Self-medication is a serious health problem that leads to an increased per capita consumption of medications , drug resistance , lack of optimal treatment , drug poisoning , and other unwanted complications .',
  'Prescription medication nonadherence among the elderly is a serious medical problem .',
  'Poor adherence with prescription medications is a serious problem in health care , especially true for patients with chronic diseases .',
  'Inappropriate medicine use remains a serious global problem .',
  'Adverse drug reactions ( ADRs ) are a severe problem .',
  'Respondents who reported a frequent use of OTC medicines were more likely to be older ( RPRa 1.03 , 95 % CI : 1.00 - 1.06 ) , have tried to lose weight by dieting in the last year ( RPRa 1.15 , 95 % CI:1.06 - 1.24 ) , be a current smoker ( RPRa 1.19 , 95 % CI:1.10 - 1.28 ) , have a serious emotional problem ( RPRa 1.48,95 % CI : 1.31 - 1.67 ) , and watch TV ( RPRa 1.24 , 95 % CI:1.16 - 1.32 ) .',
  'Suboptimal medication adherence is a serious problem in the treatment of chronic inflammatory diseases .',
  'Medication errors involving patients are a serious concern in healthcare practice .',
  'Inappropriate medications use ( IMU ) is a serious issue of global concern that leads to a waste of resources and potentially harms the patients .',
  'Predictive factors for self-medication seem to be , a high level of education , professional status and length of waiting times for a medical consultation in cases of a severe health problem .',
  'Potentially inappropriate medication ( PIM ) use is a serious public health problem in older adults because it may lead to adverse events .',
  'Nonadherence to HIV medications is a serious unsolved problem and is a major cause of morbidity and mortality in the HIV-positive population .',
  'Medication overuse is a serious concern in healthcare as it leads to increased expenditures , side effects , and morbidities .',
  'Inadequate stocking of antidotes in Taiwan : is it a serious problem ?',
  'Overall inappropriate medication use in elderly patients remains a serious problem .',
  'Compliance with taking the vitamin K1 , which required ingestion of 60 - 160 tablets/day , was a serious problem , requiring numerous follow-up calls and visits to the patient at home and work .',
  'Adverse events resulting from medication error are a serious concern .',
  'The misuse of prescription drugs is a serious public health problem .',
  'Poor medication adherence is a serious medical problem , particularly in older adults .',
  'Drug administration error is a serious problem , which warrants a well-reasoned approach to its improvement .',
  'Administration of the wrong medication is a serious and understudied problem .',
  'The so-called orphan drugs and orphan diseases , while a serious medical problem , do not present a significant volume for effective drug screening in many instances , and the FDA has developed some new approaches to circumvent this very expensive development process for patients suffering from these rare and unusual disorders .',
  'Polypharmacy , or the use of multiple medications , is a serious concern for providers who care for older adults , as polypharmacy is associated with medication nonadherence , drug-drug interactions , drug-disease interactions , and adverse drug events .',
  'The inadequate use of pharmaceuticals continues to be a severe problem in most parts of the world .',
  '[ The unjustified use of medications : a serious problem on the increase ] .',
  'Drug safety is a severe clinical pharmacology and toxicology problem that has caused immense medical and social burdens every year .',
  'Individual variation in drug response and adverse drug reactions ( ADRs ) are a serious problem in medicine .',
  'Pharmacovigilance education is essential since adverse drug reactions ( ADRs ) are a serious health problem and contribute to unnecessary patient burden and hospital admissions .',
  'Idiosyncratic drug reactions represent a serious health problem , and they remain unpredictable largely due to our limited understanding of the mechanisms involved .',
  'Non-adherence in seniors with dementia - a serious problem of routine clinical practice .',
  'Attrition due to safety reasons remains a serious problem for the pharmaceutical industry .',
  '\xa0 in clinical settings , but its adverse drug reactions ( ADRs ) can be a serious public health concern .',
  'Inappropriate drug dosage is a serious problem in pediatrics , mainly due to the lack of clinical evidence in children , suitable preparation formulation , and standardized methods for dose adjustment .',
  'In spite of being known as pharmacy of the third world , poor access to medicines in the country is always a serious concern .',
  'The agency is requiring the distribution of patient labeling , called Medication Guides , for certain products that pose a serious and significant public health concern requiring distribution of FDA-approved patient medication information .',
  'The use of potentially inappropriate medications ( PIM ) among the elderly is a serious public health problem because it is intrinsically linked to increased morbidity and mortality , causing high costs to public health systems .',
  'The prevalence of potentially inappropriate medication ( PIM ) use is high , presenting a serious public health problem .',
  'Current evidence suggests that medication errors in paediatrics are a serious problem .',
  'Inappropriate prescription has always been a serious problem in developing countries .',
  'Adverse drug reactions ( ADRs ) present a serious human health problem .',
  'Drug safety , also called pharmacovigilance , represents a serious health problem all over the world .',
  'Adverse drug events ( ADEs ) create a serious problem causing substantial harm to patients .',
  'Potentially inappropriate prescribing is a serious problem in the highly medicated long-term care population in metropolitan Quebec .',
  'Non-adherence to prescribed medications is a serious health problem in the United States , costing an estimated $ 100 billion per year .',
  'The abuse and misuse of prescription and nonprescription or the so-called Over-The-Counter ( OTC ) drugs is a serious and growing public health problem worldwide .',
  'Errors in administration of parenteral medications are a serious safety problem in intensive care units .',
  'Misuse of prescription drugs in the elderly can be a serious problem that is difficult to manage .',
  'In the multivariate analysis , only age above 70 years remained of significance for the identification of patients with a risk of a serious medication problem .',
  'Poor therapeutic adherence in homebound elderly patients receiving polypharmacy is a serious problem affecting one of every three individuals concerned , and is directly related to caregiver burden , regardless of age , sex , cognitive status or number of drugs administered .',
  'Nonadherence in children who use long-term medication is a serious problem and assessing adherence is an important step to provide solutions to this problem .',
  'Insufficient adherence of patients to treatment is a serious problem and it is monitored most frequently in hypertensive patients .',
  'Confusion about epinephrine dosing leading to iatrogenic overdose : a life-threatening problem with a potential solution .',
  'Medication errors in hospitalized children represent a serious health problem ; these include dosing errors , administration route errors , errors in identifying the patient and more .',
  'Medication-related problems are a serious concern in Australian primary care .',
  'Medication non-adherence is a serious problem for medical research and clinical practice .',
  'Healthcare risks in general , and those related to medication errors in particular , constitute a serious problem with consequent human , medical , and economic repercussions which healthcare authorities are recognizing and addressing as priority matters in some countries .',
  'Medication errors as a serious problem in world and one of the most common medical errors that threaten patient safety and may lead to even death of them .',
  "Irrational use of medicines is a serious problem in China and has been the primary target of China 's national essential medicines programme ( NEMP ) .",
  'Adverse drug effects are a serious problem in hospital patient care [ 1 ] .',
  'Industry control over the production and distribution of pharmaceutical safety and efficacy data has become a serious public health and health care funding concern .',
  'Non-adherence to cardiovascular medications is a serious problem in the aging Australian setting with an overall prevalence of between 14 and 43 \xa0 % .',
  'Use of nonprescription drugs is a serious problem that has increased over the past few years .',
  'Validation of the SOAPP was conducted by identifying those patients exhibiting aberrant drug-related behavior as determined by any of the following : a positive score on the Prescription Drug Use Questionnaire ( PDUQ ) interview , positive urine toxicology screen , and/or ratings by staff as to whether patients had a serious drug problem .',
  'Depending on definitions , reported non-adherence rates in cancer patients ranges between 16 and 100 % , which illustrates a serious problem .',
  'The World Health Organization reported in 2011 that irrational use of medicines was a serious global problem that is wasteful and harmful .',
  'Adverse drug events ( ADEs ) are a serious health problem and are the leading adverse event experienced by hospitalized patients .',
  "Based on assessment of the patient 's inventory , 40 % of the patients studied were noncompliant with their prescribed exchanges , indicating this is a serious and common problem in PD patients .",
  'Medication errors can be a serious problem that exposes patients to preventable risks .',
  'Medication errors are a serious safety concern and most errors are preventable .',
  'Polypharmacy is often prescribed for bipolar disorder , yet medication non-adherence remains a serious problem .',
  'Medication nonadherence is a serious public health concern .',
  'The irrational use of medication , by which we understand the administration of drugs for indications where their effectiveness has not been confirmed , the disregard of restrictions and warnings against their use , and the use of drug combinations which do not increase the therapeutic effect but to the contrary increase the risk of adverse drug reactions , is a serious problem encountered in paediatric pharmacotherapy .',
  'Because adverse drug events ( ADEs ) are a serious health problem and a leading cause of death , it is of vital importance to identify them correctly and in a timely manner .',
  'Irrational , wasteful , and even dangerous medicine use is a serious problem in developing countries .',
  'Despite the importance of adherence , medication nonadherence is a serious problem , with the World Health Organization noting that the average nonadherence rate is 50 % among those with chronic illnesses .',
  'Adverse drug reactions therefore represent a serious medical and financial problem .',
  'With the development of Web 2.0 technology , social media websites have become lucrative but under-explored data sources for extracting adverse drug events ( ADEs ) , which is a serious health problem .',
  'The use of potentially inappropriate medications ( PIMs ) by older people and potential prescribing omissions ( PPOs ) represent a serious problem .',
  'Medication errors are a serious and complex problem in clinical practice , especially in intensive care units whose patients can suffer potentially very serious consequences because of the critical nature of their diseases and the pharmacotherapy programs implemented in these patients .',
  'Prescription noncompliance due to cost is a serious problem for many adults with chronic disease or disability . Most would not be helped by any of the current proposals to expand Medicare drug coverage .',
  'Patient adherence to medication or lifestyle interventions is a serious concern .'],
 'axillary': ['Traction alopecia refers to (often permanent) hair loss caused by prolonged physical damage.',
  'Androgenetic alopecia (AGA) is a common hair loss disorder.',
  'An otherwise successfully performed endoscopic thoracic sympathectomy (ETS) to treat palmar hyperhidrosis (PH) often has a serious side effect: compensatory sweating (CS).',
  'Androgenetic alopecia (AGA) is a common form of scalp hair loss that affects up to 50% of males between 18 and 40 years old.',
  'Palmo-axillo-plantar hyperhidrosis (HH) exists in approximately 70% to 100% of patients complaining of HH.',
  'Hyperhidrosis is a common medical condition which can have a significant impact on quality of life.',
  'Chemotherapy-induced alopecia (CIA) is probably one of the most shocking aspects for oncological patients and underestimated by physicians',
  'A problem with mouse aminoglycoside models is that the partial loss of hair cells seen in human disease is difficult to establish consistently .',
  'Although beneficial , pain during injection in addition to unequal delivery and coverage is a major drawback of intralesional PRP in alopecia , particularly for extensive lesions and in patients with a low pain threshold .',
  'Axillary osmidrosis is a distressing social problem .',
  'Axillary bromhidrosis or osmidrosis is a distressing problem that causes a serious personal and social handicap , especially in an Asian society .',
  "Furthermore , even if hair colour change is not a life-threatening side effect , it is of deep concern for patient 's quality of life and adherence to treatment .",
  'Androgenic alopecia is a serious problem for a large proportion of the population , especially males , and causes them to seek medical help .',
  'The physician should send the patient with a severe problem directly to the nearest company headquarters or major city office to have a hair analysis , and receive suggestions from the experts of that company .',
  'Increased hair growth represents a severe problem for many women .',
  'Hyperhidrosis is a debilitating problem that is not only uncomfortable and inconvenient , but also embarrassing in work and social situations .',
  'Axillary osmidrosis is a distressing and troublesome problem that causes a serious handicap in personal and social life .',
  'Axillary osmidrosis is a distressing problem .',
  'Acne vulgaris and hirsutism are important signs related to hyperandrogenaemia and present a serious medical problem for the patients and a challenge for medical doctors in terms of effective treatment .',
  'Axillary osmidrosis is a distressing problem characterized by unpleasant odor , profuse sweating , and occasionally staining of clothes that may handicap those affected both socially and psychologically .',
  'Hirsutism is a distressing and relatively common endocrine problem in women which may prove difficult to manage .',
  'Hair loss may be a benign and transient process , or can be a serious and permanent problem .',
  'Hyperandrogenism in adolescent girls can be a troubling problem because of the difficulty in establishing a diagnosis and in prescribing appropriate therapy .',
  'Chemotherapy-induced alopecia is a distressing problem to the cancer patient for which currently there is no effective preventive measure .',
  'Axillary osmidrosis is a distressing problem , and in severe cases patients may seek a permanent solution .',
  'Female hair loss is a devastating issue for women that has only relatively recently been publicly acknowledged as a significant problem .',
  'Dandruff is a troubling consumer problem characterized by flaking and pruritus of the scalp and is considered a multifactorial condition with sebum , individual susceptibility and the fungus Malassezia all thought to play a part .',
  'Axillary osmidrosis is a distressing problem .',
  "Axillary bromhidrosis is a distressing problem , which has a strong negative effect on one 's social life .",
  'Hyperhidrosis is a troublesome problem that can be embarrassing in both social and professional situations .',
  'Axillary hyperhidrosis poses a serious problem to the affected patients .',
  "Hirsutism , a troublesome cosmetic problem , may also be a sign of serious systemic disease that can be screened for by means of the patient 's history , physical examination , and certain basic blood tests .",
  'Axillary osmidrosis is a troublesome and distressing problem .',
  "Plantar hyperhidrosis is a distressing problem that can affect a patient 's quality of life ."],
 'osmidrosis': ['Traction alopecia refers to (often permanent) hair loss caused by prolonged physical damage.',
  'Androgenetic alopecia (AGA) is a common hair loss disorder.',
  'An otherwise successfully performed endoscopic thoracic sympathectomy (ETS) to treat palmar hyperhidrosis (PH) often has a serious side effect: compensatory sweating (CS).',
  'Androgenetic alopecia (AGA) is a common form of scalp hair loss that affects up to 50% of males between 18 and 40 years old.',
  'Palmo-axillo-plantar hyperhidrosis (HH) exists in approximately 70% to 100% of patients complaining of HH.',
  'Hyperhidrosis is a common medical condition which can have a significant impact on quality of life.',
  'Chemotherapy-induced alopecia (CIA) is probably one of the most shocking aspects for oncological patients and underestimated by physicians',
  'A problem with mouse aminoglycoside models is that the partial loss of hair cells seen in human disease is difficult to establish consistently .',
  'Although beneficial , pain during injection in addition to unequal delivery and coverage is a major drawback of intralesional PRP in alopecia , particularly for extensive lesions and in patients with a low pain threshold .',
  'Axillary osmidrosis is a distressing social problem .',
  'Axillary bromhidrosis or osmidrosis is a distressing problem that causes a serious personal and social handicap , especially in an Asian society .',
  "Furthermore , even if hair colour change is not a life-threatening side effect , it is of deep concern for patient 's quality of life and adherence to treatment .",
  'Androgenic alopecia is a serious problem for a large proportion of the population , especially males , and causes them to seek medical help .',
  'The physician should send the patient with a severe problem directly to the nearest company headquarters or major city office to have a hair analysis , and receive suggestions from the experts of that company .',
  'Increased hair growth represents a severe problem for many women .',
  'Hyperhidrosis is a debilitating problem that is not only uncomfortable and inconvenient , but also embarrassing in work and social situations .',
  'Axillary osmidrosis is a distressing and troublesome problem that causes a serious handicap in personal and social life .',
  'Axillary osmidrosis is a distressing problem .',
  'Acne vulgaris and hirsutism are important signs related to hyperandrogenaemia and present a serious medical problem for the patients and a challenge for medical doctors in terms of effective treatment .',
  'Axillary osmidrosis is a distressing problem characterized by unpleasant odor , profuse sweating , and occasionally staining of clothes that may handicap those affected both socially and psychologically .',
  'Hirsutism is a distressing and relatively common endocrine problem in women which may prove difficult to manage .',
  'Hair loss may be a benign and transient process , or can be a serious and permanent problem .',
  'Hyperandrogenism in adolescent girls can be a troubling problem because of the difficulty in establishing a diagnosis and in prescribing appropriate therapy .',
  'Chemotherapy-induced alopecia is a distressing problem to the cancer patient for which currently there is no effective preventive measure .',
  'Axillary osmidrosis is a distressing problem , and in severe cases patients may seek a permanent solution .',
  'Female hair loss is a devastating issue for women that has only relatively recently been publicly acknowledged as a significant problem .',
  'Dandruff is a troubling consumer problem characterized by flaking and pruritus of the scalp and is considered a multifactorial condition with sebum , individual susceptibility and the fungus Malassezia all thought to play a part .',
  'Axillary osmidrosis is a distressing problem .',
  "Axillary bromhidrosis is a distressing problem , which has a strong negative effect on one 's social life .",
  'Hyperhidrosis is a troublesome problem that can be embarrassing in both social and professional situations .',
  'Axillary hyperhidrosis poses a serious problem to the affected patients .',
  "Hirsutism , a troublesome cosmetic problem , may also be a sign of serious systemic disease that can be screened for by means of the patient 's history , physical examination , and certain basic blood tests .",
  'Axillary osmidrosis is a troublesome and distressing problem .',
  "Plantar hyperhidrosis is a distressing problem that can affect a patient 's quality of life ."],
 'hair': ['Traction alopecia refers to (often permanent) hair loss caused by prolonged physical damage.',
  'Androgenetic alopecia (AGA) is a common hair loss disorder.',
  'An otherwise successfully performed endoscopic thoracic sympathectomy (ETS) to treat palmar hyperhidrosis (PH) often has a serious side effect: compensatory sweating (CS).',
  'Androgenetic alopecia (AGA) is a common form of scalp hair loss that affects up to 50% of males between 18 and 40 years old.',
  'Palmo-axillo-plantar hyperhidrosis (HH) exists in approximately 70% to 100% of patients complaining of HH.',
  'Hyperhidrosis is a common medical condition which can have a significant impact on quality of life.',
  'Chemotherapy-induced alopecia (CIA) is probably one of the most shocking aspects for oncological patients and underestimated by physicians',
  'A problem with mouse aminoglycoside models is that the partial loss of hair cells seen in human disease is difficult to establish consistently .',
  'Although beneficial , pain during injection in addition to unequal delivery and coverage is a major drawback of intralesional PRP in alopecia , particularly for extensive lesions and in patients with a low pain threshold .',
  'Axillary osmidrosis is a distressing social problem .',
  'Axillary bromhidrosis or osmidrosis is a distressing problem that causes a serious personal and social handicap , especially in an Asian society .',
  "Furthermore , even if hair colour change is not a life-threatening side effect , it is of deep concern for patient 's quality of life and adherence to treatment .",
  'Androgenic alopecia is a serious problem for a large proportion of the population , especially males , and causes them to seek medical help .',
  'The physician should send the patient with a severe problem directly to the nearest company headquarters or major city office to have a hair analysis , and receive suggestions from the experts of that company .',
  'Increased hair growth represents a severe problem for many women .',
  'Hyperhidrosis is a debilitating problem that is not only uncomfortable and inconvenient , but also embarrassing in work and social situations .',
  'Axillary osmidrosis is a distressing and troublesome problem that causes a serious handicap in personal and social life .',
  'Axillary osmidrosis is a distressing problem .',
  'Acne vulgaris and hirsutism are important signs related to hyperandrogenaemia and present a serious medical problem for the patients and a challenge for medical doctors in terms of effective treatment .',
  'Axillary osmidrosis is a distressing problem characterized by unpleasant odor , profuse sweating , and occasionally staining of clothes that may handicap those affected both socially and psychologically .',
  'Hirsutism is a distressing and relatively common endocrine problem in women which may prove difficult to manage .',
  'Hair loss may be a benign and transient process , or can be a serious and permanent problem .',
  'Hyperandrogenism in adolescent girls can be a troubling problem because of the difficulty in establishing a diagnosis and in prescribing appropriate therapy .',
  'Chemotherapy-induced alopecia is a distressing problem to the cancer patient for which currently there is no effective preventive measure .',
  'Axillary osmidrosis is a distressing problem , and in severe cases patients may seek a permanent solution .',
  'Female hair loss is a devastating issue for women that has only relatively recently been publicly acknowledged as a significant problem .',
  'Dandruff is a troubling consumer problem characterized by flaking and pruritus of the scalp and is considered a multifactorial condition with sebum , individual susceptibility and the fungus Malassezia all thought to play a part .',
  'Axillary osmidrosis is a distressing problem .',
  "Axillary bromhidrosis is a distressing problem , which has a strong negative effect on one 's social life .",
  'Hyperhidrosis is a troublesome problem that can be embarrassing in both social and professional situations .',
  'Axillary hyperhidrosis poses a serious problem to the affected patients .',
  "Hirsutism , a troublesome cosmetic problem , may also be a sign of serious systemic disease that can be screened for by means of the patient 's history , physical examination , and certain basic blood tests .",
  'Axillary osmidrosis is a troublesome and distressing problem .',
  "Plantar hyperhidrosis is a distressing problem that can affect a patient 's quality of life ."],
 'hyperhidrosis': ['Traction alopecia refers to (often permanent) hair loss caused by prolonged physical damage.',
  'Androgenetic alopecia (AGA) is a common hair loss disorder.',
  'An otherwise successfully performed endoscopic thoracic sympathectomy (ETS) to treat palmar hyperhidrosis (PH) often has a serious side effect: compensatory sweating (CS).',
  'Androgenetic alopecia (AGA) is a common form of scalp hair loss that affects up to 50% of males between 18 and 40 years old.',
  'Palmo-axillo-plantar hyperhidrosis (HH) exists in approximately 70% to 100% of patients complaining of HH.',
  'Hyperhidrosis is a common medical condition which can have a significant impact on quality of life.',
  'Chemotherapy-induced alopecia (CIA) is probably one of the most shocking aspects for oncological patients and underestimated by physicians',
  'A problem with mouse aminoglycoside models is that the partial loss of hair cells seen in human disease is difficult to establish consistently .',
  'Although beneficial , pain during injection in addition to unequal delivery and coverage is a major drawback of intralesional PRP in alopecia , particularly for extensive lesions and in patients with a low pain threshold .',
  'Axillary osmidrosis is a distressing social problem .',
  'Axillary bromhidrosis or osmidrosis is a distressing problem that causes a serious personal and social handicap , especially in an Asian society .',
  "Furthermore , even if hair colour change is not a life-threatening side effect , it is of deep concern for patient 's quality of life and adherence to treatment .",
  'Androgenic alopecia is a serious problem for a large proportion of the population , especially males , and causes them to seek medical help .',
  'The physician should send the patient with a severe problem directly to the nearest company headquarters or major city office to have a hair analysis , and receive suggestions from the experts of that company .',
  'Increased hair growth represents a severe problem for many women .',
  'Hyperhidrosis is a debilitating problem that is not only uncomfortable and inconvenient , but also embarrassing in work and social situations .',
  'Axillary osmidrosis is a distressing and troublesome problem that causes a serious handicap in personal and social life .',
  'Axillary osmidrosis is a distressing problem .',
  'Acne vulgaris and hirsutism are important signs related to hyperandrogenaemia and present a serious medical problem for the patients and a challenge for medical doctors in terms of effective treatment .',
  'Axillary osmidrosis is a distressing problem characterized by unpleasant odor , profuse sweating , and occasionally staining of clothes that may handicap those affected both socially and psychologically .',
  'Hirsutism is a distressing and relatively common endocrine problem in women which may prove difficult to manage .',
  'Hair loss may be a benign and transient process , or can be a serious and permanent problem .',
  'Hyperandrogenism in adolescent girls can be a troubling problem because of the difficulty in establishing a diagnosis and in prescribing appropriate therapy .',
  'Chemotherapy-induced alopecia is a distressing problem to the cancer patient for which currently there is no effective preventive measure .',
  'Axillary osmidrosis is a distressing problem , and in severe cases patients may seek a permanent solution .',
  'Female hair loss is a devastating issue for women that has only relatively recently been publicly acknowledged as a significant problem .',
  'Dandruff is a troubling consumer problem characterized by flaking and pruritus of the scalp and is considered a multifactorial condition with sebum , individual susceptibility and the fungus Malassezia all thought to play a part .',
  'Axillary osmidrosis is a distressing problem .',
  "Axillary bromhidrosis is a distressing problem , which has a strong negative effect on one 's social life .",
  'Hyperhidrosis is a troublesome problem that can be embarrassing in both social and professional situations .',
  'Axillary hyperhidrosis poses a serious problem to the affected patients .',
  "Hirsutism , a troublesome cosmetic problem , may also be a sign of serious systemic disease that can be screened for by means of the patient 's history , physical examination , and certain basic blood tests .",
  'Axillary osmidrosis is a troublesome and distressing problem .',
  "Plantar hyperhidrosis is a distressing problem that can affect a patient 's quality of life ."],
 'alopecia': ['Traction alopecia refers to (often permanent) hair loss caused by prolonged physical damage.',
  'Androgenetic alopecia (AGA) is a common hair loss disorder.',
  'An otherwise successfully performed endoscopic thoracic sympathectomy (ETS) to treat palmar hyperhidrosis (PH) often has a serious side effect: compensatory sweating (CS).',
  'Androgenetic alopecia (AGA) is a common form of scalp hair loss that affects up to 50% of males between 18 and 40 years old.',
  'Palmo-axillo-plantar hyperhidrosis (HH) exists in approximately 70% to 100% of patients complaining of HH.',
  'Hyperhidrosis is a common medical condition which can have a significant impact on quality of life.',
  'Chemotherapy-induced alopecia (CIA) is probably one of the most shocking aspects for oncological patients and underestimated by physicians',
  'A problem with mouse aminoglycoside models is that the partial loss of hair cells seen in human disease is difficult to establish consistently .',
  'Although beneficial , pain during injection in addition to unequal delivery and coverage is a major drawback of intralesional PRP in alopecia , particularly for extensive lesions and in patients with a low pain threshold .',
  'Axillary osmidrosis is a distressing social problem .',
  'Axillary bromhidrosis or osmidrosis is a distressing problem that causes a serious personal and social handicap , especially in an Asian society .',
  "Furthermore , even if hair colour change is not a life-threatening side effect , it is of deep concern for patient 's quality of life and adherence to treatment .",
  'Androgenic alopecia is a serious problem for a large proportion of the population , especially males , and causes them to seek medical help .',
  'The physician should send the patient with a severe problem directly to the nearest company headquarters or major city office to have a hair analysis , and receive suggestions from the experts of that company .',
  'Increased hair growth represents a severe problem for many women .',
  'Hyperhidrosis is a debilitating problem that is not only uncomfortable and inconvenient , but also embarrassing in work and social situations .',
  'Axillary osmidrosis is a distressing and troublesome problem that causes a serious handicap in personal and social life .',
  'Axillary osmidrosis is a distressing problem .',
  'Acne vulgaris and hirsutism are important signs related to hyperandrogenaemia and present a serious medical problem for the patients and a challenge for medical doctors in terms of effective treatment .',
  'Axillary osmidrosis is a distressing problem characterized by unpleasant odor , profuse sweating , and occasionally staining of clothes that may handicap those affected both socially and psychologically .',
  'Hirsutism is a distressing and relatively common endocrine problem in women which may prove difficult to manage .',
  'Hair loss may be a benign and transient process , or can be a serious and permanent problem .',
  'Hyperandrogenism in adolescent girls can be a troubling problem because of the difficulty in establishing a diagnosis and in prescribing appropriate therapy .',
  'Chemotherapy-induced alopecia is a distressing problem to the cancer patient for which currently there is no effective preventive measure .',
  'Axillary osmidrosis is a distressing problem , and in severe cases patients may seek a permanent solution .',
  'Female hair loss is a devastating issue for women that has only relatively recently been publicly acknowledged as a significant problem .',
  'Dandruff is a troubling consumer problem characterized by flaking and pruritus of the scalp and is considered a multifactorial condition with sebum , individual susceptibility and the fungus Malassezia all thought to play a part .',
  'Axillary osmidrosis is a distressing problem .',
  "Axillary bromhidrosis is a distressing problem , which has a strong negative effect on one 's social life .",
  'Hyperhidrosis is a troublesome problem that can be embarrassing in both social and professional situations .',
  'Axillary hyperhidrosis poses a serious problem to the affected patients .',
  "Hirsutism , a troublesome cosmetic problem , may also be a sign of serious systemic disease that can be screened for by means of the patient 's history , physical examination , and certain basic blood tests .",
  'Axillary osmidrosis is a troublesome and distressing problem .',
  "Plantar hyperhidrosis is a distressing problem that can affect a patient 's quality of life ."],
 'vascular': ['Prolonged immobility in the sitting position in the elderly is known to produce venous stasis with leg edema and possible skin changes.',
  'Kawasaki disease (KD) is an acute febrile systemic vasculitis that affects small and medium blood vessels',
  'Takayasu arteritis (TA) is a chronic inflammatory disease that induces stenosis, occlusion, or aneurysmal degeneration of the aorta and its major branches',
  'Digital ischemia is a serious problem in peripheral artery diseases ( PAD ) patients .',
  'Peripheral artery disease ( PAD ) is becoming a serious health problem of present times .',
  'In an aging population vascular disorders well exemplified by the chronic limb ischemia , chronic heart failure , cerebral ischemia and age-related macular degeneration represent a serious medical and socio-economical problem .',
  'Occlusive diseases of arteries of the lower extremities with underlying atherosclerosis present a serious medical problem .',
  'Disease associated with the vascular system , including peripheral arterial disease , poses a serious health problem with incidence growing annually .',
  'Peripheral arterial occlusive disease ( PAOD ) continues to be a vexing problem despite the advent of endovascular techniques augmenting traditional open repair .',
  'Chronic limb ischemia is a serious clinical problem .',
  'Critical limb ischemia , a severe manifestation of peripheral artery disease , is emerging as a major concern in aging societies worldwide .',
  'Arteriosclerotic diseases are becoming a serious problem all over the world .',
  'In this context , vascular disease represents a serious public health problem , particularly if we take into account current forecasts on population ageing .',
  'Peripheral ischemic vascular disease represents a serious problem with high mortality and morbidity .',
  'Vascular disease is a serious public health problem in the industrialized world , and is a frequent cause of death among the adult population of Brazil .',
  'Peripheral vascular disease ( PVD ) is a devastating medical problem that may lead to significant life alterations for patients , from simply limiting their daily activities to potential loss of limbs and eventual demise .'],
 'limb': ['Prolonged immobility in the sitting position in the elderly is known to produce venous stasis with leg edema and possible skin changes.',
  'Kawasaki disease (KD) is an acute febrile systemic vasculitis that affects small and medium blood vessels',
  'Takayasu arteritis (TA) is a chronic inflammatory disease that induces stenosis, occlusion, or aneurysmal degeneration of the aorta and its major branches',
  'Digital ischemia is a serious problem in peripheral artery diseases ( PAD ) patients .',
  'Peripheral artery disease ( PAD ) is becoming a serious health problem of present times .',
  'In an aging population vascular disorders well exemplified by the chronic limb ischemia , chronic heart failure , cerebral ischemia and age-related macular degeneration represent a serious medical and socio-economical problem .',
  'Occlusive diseases of arteries of the lower extremities with underlying atherosclerosis present a serious medical problem .',
  'Disease associated with the vascular system , including peripheral arterial disease , poses a serious health problem with incidence growing annually .',
  'Peripheral arterial occlusive disease ( PAOD ) continues to be a vexing problem despite the advent of endovascular techniques augmenting traditional open repair .',
  'Chronic limb ischemia is a serious clinical problem .',
  'Critical limb ischemia , a severe manifestation of peripheral artery disease , is emerging as a major concern in aging societies worldwide .',
  'Arteriosclerotic diseases are becoming a serious problem all over the world .',
  'In this context , vascular disease represents a serious public health problem , particularly if we take into account current forecasts on population ageing .',
  'Peripheral ischemic vascular disease represents a serious problem with high mortality and morbidity .',
  'Vascular disease is a serious public health problem in the industrialized world , and is a frequent cause of death among the adult population of Brazil .',
  'Peripheral vascular disease ( PVD ) is a devastating medical problem that may lead to significant life alterations for patients , from simply limiting their daily activities to potential loss of limbs and eventual demise .'],
 'tendon': ['Controversy exists regarding whether the kinesiology tape application direction affects muscle strength.',
  'Tendon ruptures are common musculoskeletal injuries all around the world.',
  'Kinesiology tape can improve athletic performance; however, due to cutaneous stimulation its application can have an influence on proprioception.',
  'Patellar dislocations are a common orthopedic emergency with several variants',
  'Shoulder dislocations are a common presentation to the emergency department and one of the most frequent types of joint dislocations',
  'Compared to a weight-stack leg-extension equipment , an elastic resistance optimized setting has the potential to give a more effective quadriceps activation across the range of motion , and greatly reduces the anterior cruciate ligament strain force , which represents the main drawback of existing open kinetic-chain knee-extension exercises .',
  'Acute compartment syndromes result from swelling within a limited space and remain a serious concern clinically when swelling is anticipated under any type of constraining cast .',
  'A non-contact anterior cruciate ligament ( ACL ) injury is both a serious and very common problem in volleyball .',
  'Hypercholesterolemia is a serious health problem that is associated not only with heart disease , but also tendon pathology .',
  'Shoulder injuries from repetitive baseball pitching continue to be a serious , common problem .',
  'Chronic medial elbow instability can be a debilitating problem for the throwing athlete .',
  'Ring avulsion injuries pose a serious problem for the hand surgeon .',
  'Suppurative tenosynovitis involving the digital fibrous flexor sheaths in the hand can be a devastating problem .',
  'In spite of improvement in surgical technique and suture material , the end result of sutured flexor tendons still represent a serious problem .',
  'Concomitant soft tissue injury resulting from knee instability following cruciate rupture is a serious clinical problem .',
  'Atrophic nonunion of the distal humerus in children with osteogenesis imperfecta is a vexing and disabling problem .',
  'Tendinopathy is a vexing clinical problem as its onset and development is often asymptomatic and unrecognized until tendon rupture .',
  'Adhesion formation following tendon injury is a serious clinical problem .',
  'Quadriceps tendon rupture is a severe and demanding problem in knee surgery , especially when it is recurrent and when elderly patients are involved .',
  'Ankle sprains are a serious problem in high school sports , with high rates of recurrent injury and loss of participation from sport .',
  'Compartment syndrome of the forearm is a serious medical problem , and it is commonly associated with high-energy injuries to the upper extremity .',
  'Patellofemoral instability is a severe problem in young and active patients .',
  'Flexor tendon repair in zone II remains a vexing problem .',
  'Tendon adhesion is a serious problem and it affects tendon gliding and joint motion .',
  'Editorial Commentary : Concomitant Surgical Management for Rotator Cuff Tears With Adhesive Capsulitis is an Effective Treatment for Managing a Vexing Problem .',
  'Traumatic anterior shoulder instability from recurrent dislocations or subluxations is a debilitating problem for the teenage athlete .',
  'Compartment syndromes of the upper arm are rare clinical entities but can be a serious problem , especially in unconscious patients or those presenting with altered mental status .',
  'Since tendon rupture is a serious problem that not uncommonly follows hook of the hamate fracture , a high index of suspicion must be maintained when initially evaluating these injuries .',
  'Tendon lesions are still a serious clinical problem .',
  'With advances in radiology , anesthesia , antisepsis , and hardware technology , surgical treatment is now generally preferred , yet loss of elbow joint mobility can still be a vexing problem .',
  'Injuries of the knee and ankle joint are a serious ongoing problem in soccer .',
  'An elbow contracture in a young person can be a devastating problem .',
  'Tendon injuries clinically represent a serious and still unresolved problem since damaged tendon tissues heal very slowly and no surgical treatment can restore a damaged tendon to its normal structural integrity and mechanical strength .',
  'Neglected rupture of the patellar tendon can be a debilitating problem .',
  'Tendinopathy is a serious health problem and its etiology is not fully elucidated .',
  'Tendon injuries like tendinopathy are a serious healthcare problem in the United States .',
  'Plantar fasciitis is a debilitating and painful problem present in the general population .',
  'Incongruency of the shoulder in adolescence poses a serious therapeutic problem .',
  'Pain of the shoulder is becoming a serious clinical problem .',
  'Anterior cruciate ligament ( ACL ) injuries are a serious problem , with a high incidence and serious consequences .',
  'Post-traumatic joint stiffness ( PTJS ) of the elbow is a debilitating condition that poses unique treatment challenges .',
  'Adhesion formation during tendon healing remains a severe problem in clinical practice .',
  'Adhesion formation is a serious problem after flexor tendon repair .',
  'Tendon injuries continue to be a vexing clinical problem faced by the upper extremity surgeon .',
  'Achilles tendinopathy is a serious and frequently occurring problem , especially in elite athletes .',
  'Chronic elbow injuries from tumbling in female gymnastics present a serious problem for performers .'],
 'elbow': ['Controversy exists regarding whether the kinesiology tape application direction affects muscle strength.',
  'Tendon ruptures are common musculoskeletal injuries all around the world.',
  'Kinesiology tape can improve athletic performance; however, due to cutaneous stimulation its application can have an influence on proprioception.',
  'Patellar dislocations are a common orthopedic emergency with several variants',
  'Shoulder dislocations are a common presentation to the emergency department and one of the most frequent types of joint dislocations',
  'Compared to a weight-stack leg-extension equipment , an elastic resistance optimized setting has the potential to give a more effective quadriceps activation across the range of motion , and greatly reduces the anterior cruciate ligament strain force , which represents the main drawback of existing open kinetic-chain knee-extension exercises .',
  'Acute compartment syndromes result from swelling within a limited space and remain a serious concern clinically when swelling is anticipated under any type of constraining cast .',
  'A non-contact anterior cruciate ligament ( ACL ) injury is both a serious and very common problem in volleyball .',
  'Hypercholesterolemia is a serious health problem that is associated not only with heart disease , but also tendon pathology .',
  'Shoulder injuries from repetitive baseball pitching continue to be a serious , common problem .',
  'Chronic medial elbow instability can be a debilitating problem for the throwing athlete .',
  'Ring avulsion injuries pose a serious problem for the hand surgeon .',
  'Suppurative tenosynovitis involving the digital fibrous flexor sheaths in the hand can be a devastating problem .',
  'In spite of improvement in surgical technique and suture material , the end result of sutured flexor tendons still represent a serious problem .',
  'Concomitant soft tissue injury resulting from knee instability following cruciate rupture is a serious clinical problem .',
  'Atrophic nonunion of the distal humerus in children with osteogenesis imperfecta is a vexing and disabling problem .',
  'Tendinopathy is a vexing clinical problem as its onset and development is often asymptomatic and unrecognized until tendon rupture .',
  'Adhesion formation following tendon injury is a serious clinical problem .',
  'Quadriceps tendon rupture is a severe and demanding problem in knee surgery , especially when it is recurrent and when elderly patients are involved .',
  'Ankle sprains are a serious problem in high school sports , with high rates of recurrent injury and loss of participation from sport .',
  'Compartment syndrome of the forearm is a serious medical problem , and it is commonly associated with high-energy injuries to the upper extremity .',
  'Patellofemoral instability is a severe problem in young and active patients .',
  'Flexor tendon repair in zone II remains a vexing problem .',
  'Tendon adhesion is a serious problem and it affects tendon gliding and joint motion .',
  'Editorial Commentary : Concomitant Surgical Management for Rotator Cuff Tears With Adhesive Capsulitis is an Effective Treatment for Managing a Vexing Problem .',
  'Traumatic anterior shoulder instability from recurrent dislocations or subluxations is a debilitating problem for the teenage athlete .',
  'Compartment syndromes of the upper arm are rare clinical entities but can be a serious problem , especially in unconscious patients or those presenting with altered mental status .',
  'Since tendon rupture is a serious problem that not uncommonly follows hook of the hamate fracture , a high index of suspicion must be maintained when initially evaluating these injuries .',
  'Tendon lesions are still a serious clinical problem .',
  'With advances in radiology , anesthesia , antisepsis , and hardware technology , surgical treatment is now generally preferred , yet loss of elbow joint mobility can still be a vexing problem .',
  'Injuries of the knee and ankle joint are a serious ongoing problem in soccer .',
  'An elbow contracture in a young person can be a devastating problem .',
  'Tendon injuries clinically represent a serious and still unresolved problem since damaged tendon tissues heal very slowly and no surgical treatment can restore a damaged tendon to its normal structural integrity and mechanical strength .',
  'Neglected rupture of the patellar tendon can be a debilitating problem .',
  'Tendinopathy is a serious health problem and its etiology is not fully elucidated .',
  'Tendon injuries like tendinopathy are a serious healthcare problem in the United States .',
  'Plantar fasciitis is a debilitating and painful problem present in the general population .',
  'Incongruency of the shoulder in adolescence poses a serious therapeutic problem .',
  'Pain of the shoulder is becoming a serious clinical problem .',
  'Anterior cruciate ligament ( ACL ) injuries are a serious problem , with a high incidence and serious consequences .',
  'Post-traumatic joint stiffness ( PTJS ) of the elbow is a debilitating condition that poses unique treatment challenges .',
  'Adhesion formation during tendon healing remains a severe problem in clinical practice .',
  'Adhesion formation is a serious problem after flexor tendon repair .',
  'Tendon injuries continue to be a vexing clinical problem faced by the upper extremity surgeon .',
  'Achilles tendinopathy is a serious and frequently occurring problem , especially in elite athletes .',
  'Chronic elbow injuries from tumbling in female gymnastics present a serious problem for performers .'],
 'mental': ['The prevalence of mental health difficulties in Northern Ireland (NI) is significantly higher than in England.',
  'Families living with a person with mental illness can experience distress requiring therapeutic interventions.',
  'There is a lack of treatment plurality at step 2 of Improving Access to Psychological Therapies (IAPT) services.',
  'Borderline personality disorder (BPD) is one of the most puzzling psychiatric disorders',
  'There is a strong stigma attached to mental disorders preventing those affected from getting psychological help',
  'One problem with e-mental-health is that provision is fragmented , and there is no national overview , while insight into quality is important for patients and professionals .',
  'Services and resources are now split for those with a severe and enduring mental illness and those with a common mental problem .',
  'Mental health is a serious problem in Latin America where many communities have been directly affected by armed conflict , communities in which large population groups have been displaced or have sought refuge .',
  'Bipolar affective disorder ( BAD ) is a severe mental illness which results in serious lifelong struggles and challenges .',
  'Borderline personality disorder ( BPD ) is a severe mental condition characterized by a range of cognitive and behavioral vulnerabilities , including chronic shame and deficits in social problem solving ( SPS ) abilities .',
  'Unmet need for mental health care is a serious public health problem .',
  'Loss of follow-up information regarding the adjustment of people who have received mental health services has been a troublesome problem when comparing the effectiveness of different treatment programs .',
  'Mental illness stigma is a serious societal problem and a critical impediment to treatment seeking for mentally ill people .',
  'Borderline personality disorder ( BPD ) is a serious public health problem .',
  'A serious and chronic problem that confronts mentally ill people and mental health professionals is the inability of society to provide the requisite resources for adequate care-giving systems .',
  'Mental health issues in children have become a serious public health concern in the U.S. within the past few decades .',
  'Borderline personality disorder is a serious mental health problem for which one of its main characteristics is significant difficulties in relationships with others .',
  'Though it is driving the economies of most of the nations of the world , a serious concern regarding the impact of urbanization on mental health is warranted .',
  'Psychiatric symptoms and disorders are a serious problem area , absorbing high health service provision capacities .',
  'Developmental behavioural disorders in early childhood are a serious public health problem , because they signify a higher risk of social , regulatory and emotional impairment in later life .',
  'The Ugandan government recognizes mental health as a serious public health and development concern , and',
  'In addition , malingering may be a serious problem that can affect valid treatment due to an intentional production of false or grossly exaggerated physical or psychological symptoms , motivated by external incentive such as avoiding military duty or obtaining financial compensation .',
  'Stigma is a serious problem affecting the mental health services .',
  'Inappropriate treatment of BPD is a serious problem in the US population .',
  'Common mental disorders ( CMD ) represent a serious , growing public health concern , especially in women .',
  'Stigmatization of people with mental illness in health care is a serious problem contributing to poor provision of health care and preventive medicine , it decreases their willingness to seek help and reduces quality of their life and life expectancy .',
  'Iatrogenia produced by care systems activity is a serious public health problem and in mental health is poorly understood .',
  'Together , these studies suggest that traditional methods of teaching psychopathology do not lessen mental illness stigma , a serious concern that can potentially be reconciled by incorporating more person-centered instructional methods .',
  'Dissociative symptoms including flashbacks , i.e. vivid scenic recollections of traumatic episodes , in patients with Borderline Personality Disorder are a serious and often treatment-refractory problem .',
  'Stigma is a serious concern for individuals with BD and their families .',
  'This may introduce a serious bias into psychiatric family study data , leading to overestimation of the strength of the tendency for mental disorders to " run in families . " Family studies that rely on the informant method in their diagnostic evaluations should be aware of this problem .',
  'Poor mental health among those living in poverty is a serious global public health concern .',
  'About 17 % of the psychiatrists perceive stigma as a serious problem , with a higher rate in younger respondents .',
  'However , unlike developed countries which are endowed with many and relatively well-paid mental health specialists , low-income countries face a dire shortage of highly trained mental health professionals in addition to several other challenges .',
  'Risk management is a serious concern in community mental healthcare where there is less direct , real-time supervision of clients than in other settings , and because inadequate management of risk can have fatal consequences when service users are a risk to themselves and/or others .',
  'The deinstitutionalization movement has given rise to an increasing number of young adult chronic patients in the community , a situation that poses a serious problem for both psychiatry and society .',
  'This is seen as a serious public health problem , which needs to be addressed by educational steps directed at general practitioners ( GPs ) , mental health clinicians , and perhaps also the general public .',
  'Because psychoanalysis comprises a theory based on practice , the dearth of clinical material for study , training and research purposes is a serious problem for analysts .',
  'Mental Disorders constitute a severe Public Health problem in developing countries due to inadequate resources specially in terms of trained personnel ; furthermore , Mental Health care is given out only in specialized Institutions where it has not been possible to provide coverage for more than a small part of the population .',
  'Lack of access to support , services , and providers for children and adolescents with mental health conditions is a serious problem in the United States .',
  'Mental health treatment dropout is a serious problem , especially among patients who have low income , are young , lack insurance , are offered only single-modality treatments , and have negative attitudes about mental health care .',
  'Premature termination from group psychotherapy continues to be a serious problem in the treatment of patients with borderline personality disorder ( BPD ) .',
  'Mental illness is a serious concern .',
  'Psychiatric disorders are a serious public health problem , especially as many psychiatric disorders begin early in life .',
  'Twentieth century psychiatric epidemiologists , however , faced a severe intellectual problem ; their work rested on a descriptive rather than an etiological nosology .',
  'Globally mental health problems are a serious public health concern .',
  'Failure to seek treatment for mental health disorders is a serious public health concern .',
  'When a patient with a serious mental illness expresses a desire for children , mental health professionals are faced with an ethical dilemma .',
  'Bipolar Disorder ( BD ) is a severe mental health problem .',
  'Mental disorders are a severe health problem , and the number of patients is growing worldwide .',
  'Bipolar affective disorder is a serious and enduring mental health problem , which is associated with high mortality rates worldwide .',
  'This is a serious public health concern , as mental health conditions persist into adulthood .',
  'The author foresees that the Government will face a serious problem in future to cater for the increasing number of chronic schizophrenic patients in the community if it does not take immediate action to improve mental health services in the country .',
  'However , the risk of mania in vulnerable individuals remains a serious concern .',
  'Borderline personality disorder ( BPD ) is a severe and generally chronic disorder that presents patients and their family members with multiple challenges .'],
 'distress': ['Etiologies contributing to failure to wean from mechanical ventilation (MV) are multiple, resulting in morbid and costly outcomes.',
  'Acute lung injury ( ALI ) and the subsequent multi-system organ failure is a serious health problem with devastating impacts on the health care systems .',
  'Acute lung injury ( ALI ) is a severe inflammatory condition that develops in response to local and systemic lung challenges .',
  'Prolonged support of organ functions without therapeutic benefit represents a serious problem of therapy in intensive care units ( ICUs ) .',
  'Acute respiratory distress syndrome continues to be a vexing clinical problem with no specific therapy .',
  'Massive unilateral pulmonary injury poses a severe ventilatory problem .',
  'Acute respiratory distress syndrome ( ARDS ) still represents a serious problem in clinical routine and is associated with a high mortality .',
  'Hypoxemia during one-lung ventilation ( OLV ) remains a serious problem , particularly in the supine position .',
  'Acute lung injury ( ALI ) is a serious clinical problem .',
  'Patient-ventilator asynchrony is a serious problem that is associated with prolonged mechanical ventilation , prolonged ICU and hospital stays , and increased mortality .',
  'The acute respiratory distress syndrome ( ARDS ) remains a serious clinical problem with the current treatment being supportive in the form of mechanical ventilation .',
  'The acute respiratory distress syndrome ( ARDS ) is a serious and complex clinical problem that often threatens the lives of patients .',
  '1 . Acute lung injury ( ALI ) or acute respiratory distress syndrome is a serious clinical problem with high mortality .',
  '[ Pediatric acute respiratory distress syndrome : a severe problem than yet to be conquered by critical care medicine ] .',
  'Discriminating cardiogenic pulmonary edema ( CPE ) from acute respiratory distress syndrome ( ARDS ) is a serious problem in emergency departments , and the ability of chest radiographs to differentiate between these 2 entities is limited .',
  'Acute respiratory distress syndrome ( ARDS ) represents a serious problem in critically ill patients and is associated with in-hospital mortality rates of 33%-52 % .',
  'Diabetes is a devastating global health problem and is considered a predisposing factor for lung injury progression .',
  'Acute lung injury ( ALI ) is a devastating clinical problem with a mortality as high as 60 % .',
  'Acute respiratory distress syndrome ( ARDS ) remains a serious clinical problem with the main treatment being supportive in the form of mechanical ventilation .',
  'Despite improvements in critical care , acute respiratory distress syndrome ( ARDS ) remains a devastating clinical problem with high rates of morbidity and mortality .',
  'Smoke inhalation leads to acute lung injury ( ALI ) , a devastating clinical problem associated with high mortality rates .',
  'Acute respiratory distress syndrome ( ARDS ) is a serious clinical problem that has a 30 - 50 % mortality rate .',
  'Acute lung injury or acute respiratory distress syndrome is a serious clinical problem with high mortality .',
  'Smoke inhalation leads to acute lung injury ( ALI ) , a devastating clinical problem associated with high mortality .',
  'Acute respiratory distress syndrome ( ARDS ) causes a heterogeneous lung injury and remains a serious medical problem , with one of the only treatments being supportive care in the form of mechanical ventilation .'],
 'ards': ['Etiologies contributing to failure to wean from mechanical ventilation (MV) are multiple, resulting in morbid and costly outcomes.',
  'Acute lung injury ( ALI ) and the subsequent multi-system organ failure is a serious health problem with devastating impacts on the health care systems .',
  'Acute lung injury ( ALI ) is a severe inflammatory condition that develops in response to local and systemic lung challenges .',
  'Prolonged support of organ functions without therapeutic benefit represents a serious problem of therapy in intensive care units ( ICUs ) .',
  'Acute respiratory distress syndrome continues to be a vexing clinical problem with no specific therapy .',
  'Massive unilateral pulmonary injury poses a severe ventilatory problem .',
  'Acute respiratory distress syndrome ( ARDS ) still represents a serious problem in clinical routine and is associated with a high mortality .',
  'Hypoxemia during one-lung ventilation ( OLV ) remains a serious problem , particularly in the supine position .',
  'Acute lung injury ( ALI ) is a serious clinical problem .',
  'Patient-ventilator asynchrony is a serious problem that is associated with prolonged mechanical ventilation , prolonged ICU and hospital stays , and increased mortality .',
  'The acute respiratory distress syndrome ( ARDS ) remains a serious clinical problem with the current treatment being supportive in the form of mechanical ventilation .',
  'The acute respiratory distress syndrome ( ARDS ) is a serious and complex clinical problem that often threatens the lives of patients .',
  '1 . Acute lung injury ( ALI ) or acute respiratory distress syndrome is a serious clinical problem with high mortality .',
  '[ Pediatric acute respiratory distress syndrome : a severe problem than yet to be conquered by critical care medicine ] .',
  'Discriminating cardiogenic pulmonary edema ( CPE ) from acute respiratory distress syndrome ( ARDS ) is a serious problem in emergency departments , and the ability of chest radiographs to differentiate between these 2 entities is limited .',
  'Acute respiratory distress syndrome ( ARDS ) represents a serious problem in critically ill patients and is associated with in-hospital mortality rates of 33%-52 % .',
  'Diabetes is a devastating global health problem and is considered a predisposing factor for lung injury progression .',
  'Acute lung injury ( ALI ) is a devastating clinical problem with a mortality as high as 60 % .',
  'Acute respiratory distress syndrome ( ARDS ) remains a serious clinical problem with the main treatment being supportive in the form of mechanical ventilation .',
  'Despite improvements in critical care , acute respiratory distress syndrome ( ARDS ) remains a devastating clinical problem with high rates of morbidity and mortality .',
  'Smoke inhalation leads to acute lung injury ( ALI ) , a devastating clinical problem associated with high mortality rates .',
  'Acute respiratory distress syndrome ( ARDS ) is a serious clinical problem that has a 30 - 50 % mortality rate .',
  'Acute lung injury or acute respiratory distress syndrome is a serious clinical problem with high mortality .',
  'Smoke inhalation leads to acute lung injury ( ALI ) , a devastating clinical problem associated with high mortality .',
  'Acute respiratory distress syndrome ( ARDS ) causes a heterogeneous lung injury and remains a serious medical problem , with one of the only treatments being supportive care in the form of mechanical ventilation .'],
 'lung': ['Etiologies contributing to failure to wean from mechanical ventilation (MV) are multiple, resulting in morbid and costly outcomes.',
  'Lung cancer is the leading cause of cancer mortality worldwide',
  'Lung adenocarcinoma (LUAD) is one of the most common malignancies, and is a serious threat to human health',
  'Non-small cell lung cancer (NSCLC) remains the leading cause of cancer death worldwide, although important advances in target therapy have been developed in the past few years',
  'The main problem with the tumours present in the lungs is that they are non-stationary during each respiratory cycle .',
  'A major drawback of lung cancer screening programs is the high frequency of false-positive findings on computed tomography ( CT ) .',
  'Lung cancer remains a serious public health problem and is the first cause of cancer death worldwide , and the overall 5-year survival rate for all stages is 14 - 17 \xa0 % for Non-small-cell lung cancer and 6 \xa0 % for small-cell lung cancer .',
  'Acute lung injury ( ALI ) and the subsequent multi-system organ failure is a serious health problem with devastating impacts on the health care systems .',
  'Acute lung injury ( ALI ) is a severe inflammatory condition that develops in response to local and systemic lung challenges .',
  'Lung cancer still poses a serious epidemiological problem in Poland and the number of years of life lost due to this cause reflects social and economic implications of premature lung cancer-related mortality .',
  'Lung cancer remains a serious oncological problem worldwide .',
  'Prolonged support of organ functions without therapeutic benefit represents a serious problem of therapy in intensive care units ( ICUs ) .',
  'Diagnostics and treatment of bronchogenic non-small cell lung carcinoma is a severe clinical problem .',
  'Lung cancer is a serious public health problem and Non Small Cell Lung Carcinoma , NSCLC , is particularly resistant to current treatments .',
  'Treatment of patients with advanced non-small cell lung cancer ( NSCLC ) remains a vexing problem and long-term survival beyond 5 years is extremely rare .',
  'Lung cancer is a serious health problem , since it is one of the leading causes for death worldwide .',
  'Lung cancer is a fatal disease and a serious health problem worldwide .',
  'Acute respiratory distress syndrome continues to be a vexing clinical problem with no specific therapy .',
  'Massive unilateral pulmonary injury poses a severe ventilatory problem .',
  'Acute respiratory distress syndrome ( ARDS ) still represents a serious problem in clinical routine and is associated with a high mortality .',
  'Lung cancer is not only a serious disease but also a public problem threatening human health all over the world .',
  'Non-small cell lung cancer ( NSCLC ) is a serious health problem .',
  'Idiopathic pulmonary fibrosis ( IPF ) is a fatal growing problem , with limited therapeutic options .',
  'Hypoxemia during one-lung ventilation ( OLV ) remains a serious problem , particularly in the supine position .',
  'Lung cancer ( LC ) is a serious health problem due to its high incidence and mortality .',
  'Non-small cell lung cancer ( NSCLC ) has become a serious global health problem in the 21st century , and tumor proliferation and metastasis are the leading causes of death in patients with lung cancer .',
  'Pulmonary fibrosis is a vexing clinical problem with no proven therapeutic options .',
  'Acute lung injury ( ALI ) is a serious clinical problem .',
  'Treatment-related death ( TRD ) remains a serious problem in small-cell lung cancer ( SCLC ) , despite recent improvements in supportive care .',
  'Lung cancer is a serious health problem and leading cause of death worldwide due to its high incidence and mortality .',
  'Fibrosis is also a serious cosmetic problem for patients , and in some cases it can also imply pain .',
  'Patient-ventilator asynchrony is a serious problem that is associated with prolonged mechanical ventilation , prolonged ICU and hospital stays , and increased mortality .',
  'Lung cancer is a serious health problem in most developed countries and its incidence rate is profusely increasing .',
  'Lung cancer is a serious health problem in public .',
  'The acute respiratory distress syndrome ( ARDS ) remains a serious clinical problem with the current treatment being supportive in the form of mechanical ventilation .',
  'The acute respiratory distress syndrome ( ARDS ) is a serious and complex clinical problem that often threatens the lives of patients .',
  'Pulmonary fibrosis is a progressively aggravating lethal disease that is a serious public health concern .',
  'Drug-induced interstitial lung disease ( ILD ) , particularly pulmonary fibrosis , is a serious clinical concern and myofibroblasts have been suggested to have a major role , with it recently being revealed that some of these myofibroblasts are derived from lung epithelial cells through epithelial-mesenchymal transition ( EMT ) .',
  'Lung cancer among blacks is a serious public health problem , with a mortality rate of 119 per 100,000 among black males compared to 81 per 100,000 for white males .',
  '1 . Acute lung injury ( ALI ) or acute respiratory distress syndrome is a serious clinical problem with high mortality .',
  '[ Pediatric acute respiratory distress syndrome : a severe problem than yet to be conquered by critical care medicine ] .',
  'Lung cancer still accounts for the leading cause of cancer-related deaths worldwide and despite the emerging advances in diagnostic and therapeutic techniques it remains to be a serious global public health concern .',
  'Discriminating cardiogenic pulmonary edema ( CPE ) from acute respiratory distress syndrome ( ARDS ) is a serious problem in emergency departments , and the ability of chest radiographs to differentiate between these 2 entities is limited .',
  'Acute respiratory distress syndrome ( ARDS ) represents a serious problem in critically ill patients and is associated with in-hospital mortality rates of 33%-52 % .',
  'Lung cancer is a serious health problem and the leading cause of cancer death worldwide , due to its high incidence and mortality .',
  'Diabetes is a devastating global health problem and is considered a predisposing factor for lung injury progression .',
  'Although lung cancer is an avoidable disease , it is a serious problem in the Leon Healthcare Area .',
  'Despite some positive signals ( decline of the lung cancer incidence in men ) , lung cancer still remains a serious medical and social problem .',
  'Acute lung injury ( ALI ) is a devastating clinical problem with a mortality as high as 60 % .',
  'Acute respiratory distress syndrome ( ARDS ) remains a serious clinical problem with the main treatment being supportive in the form of mechanical ventilation .',
  'Despite improvements in critical care , acute respiratory distress syndrome ( ARDS ) remains a devastating clinical problem with high rates of morbidity and mortality .',
  'Fibrosis is a serious health problem often leading to accompanying organ failure .',
  'At present , the diagnosis and treatment of lung cancer combined with COPD is a serious problem , which needs to be paid attention to by thoracic surgeons and to join hands with physicians in order to improve the diagnosis level of COPD .',
  'Misdiagnosis of lung cancer remains a serious problem due to the difficulty of distinguishing lung cancer from other respiratory lung diseases .',
  'Smoke inhalation leads to acute lung injury ( ALI ) , a devastating clinical problem associated with high mortality rates .',
  'The recent increase in the use of helical CT has produced a higher detection rate of small pulmonary nodules than in conventional CT application , and has presented a serious problem in their treatment .',
  'These projections indicate that lung cancer incidence and mortality will remain a serious problem in the Aragon ( Spain ) , and that a more intense primary prevention program is needed .',
  'Lung cancer is a serious health problem in China ,',
  'This data shows an increasing frequency of lung cancer in Mexico city as well as other countries , it also shows that it is going to be a serious health problem in the future .',
  'Lung cancer is a serious public health problem .',
  'Patients presenting with a solitary pulmonary nodule are often a serious diagnostic-therapeutic problem .',
  'The results suggested that chronic airway inflammation in ICS is not such a serious problem compared with DPB and BE .',
  'Acute respiratory distress syndrome ( ARDS ) is a serious clinical problem that has a 30 - 50 % mortality rate .',
  'Multi-cause-induced interstitial lung disease , particularly pulmonary fibrosis , is a serious clinical concern .',
  'Acute lung injury or acute respiratory distress syndrome is a serious clinical problem with high mortality .',
  'Idiopathic pulmonary fibrosis ( IPF ) is a serious lung problem with advancing and diffusive pulmonary fibrosis as the pathologic basis , and with oxidative stress and inflammation as the key pathogenesis .',
  'The results of this study indicate that upper aerodigestive tract cancers represent a serious problem for public health .',
  'Pulmonary fibrosis remains a serious biomedical problem with no cure and an urgent need for better therapies .',
  'Growing number of elderly lung cancer patients reflecting a lengthening life span has become a serious problem .',
  'The frequency of detection of peripheral pulmonary lesion ( PPL ) in suspected early lung cancer has been increasing , and whether preoperative pathological diagnosis ( PPD ) for small PPLs should always be established before their surgical resection can become a worrisome problem for physicians .',
  'Fibrosis is a severe and progressive sequel of many pulmonary diseases , has no effective therapy at present and , consequently , represents a serious health problem .',
  'Asymptomatic solitary pulmonary nodules incidentally revealed by computed tomography has become a serious medical problem .',
  'Lung cancer ( LC ) is a serious public health problem responsible for the majority of cancer deaths and comorbidities in developed countries .',
  'The possibility that a demonstrated lung carcinogen may be present in large numbers of homes raises a serious public health concern .',
  'Smoke inhalation leads to acute lung injury ( ALI ) , a devastating clinical problem associated with high mortality .',
  'Lung diseases remain a serious problem for public health .',
  'Chemotherapy toxicity is a serious problem from which non-small cell lung cancer ( NSCLC ) patients suffer .',
  'Acute respiratory distress syndrome ( ARDS ) causes a heterogeneous lung injury and remains a serious medical problem , with one of the only treatments being supportive care in the form of mechanical ventilation .',
  'Lung cancer is a serious health problem and the leading cause of cancer death worldwide .'],
 'ventilation': ['Etiologies contributing to failure to wean from mechanical ventilation (MV) are multiple, resulting in morbid and costly outcomes.',
  'Acute lung injury ( ALI ) and the subsequent multi-system organ failure is a serious health problem with devastating impacts on the health care systems .',
  'Acute lung injury ( ALI ) is a severe inflammatory condition that develops in response to local and systemic lung challenges .',
  'Prolonged support of organ functions without therapeutic benefit represents a serious problem of therapy in intensive care units ( ICUs ) .',
  'Acute respiratory distress syndrome continues to be a vexing clinical problem with no specific therapy .',
  'Massive unilateral pulmonary injury poses a severe ventilatory problem .',
  'Acute respiratory distress syndrome ( ARDS ) still represents a serious problem in clinical routine and is associated with a high mortality .',
  'Hypoxemia during one-lung ventilation ( OLV ) remains a serious problem , particularly in the supine position .',
  'Acute lung injury ( ALI ) is a serious clinical problem .',
  'Patient-ventilator asynchrony is a serious problem that is associated with prolonged mechanical ventilation , prolonged ICU and hospital stays , and increased mortality .',
  'The acute respiratory distress syndrome ( ARDS ) remains a serious clinical problem with the current treatment being supportive in the form of mechanical ventilation .',
  'The acute respiratory distress syndrome ( ARDS ) is a serious and complex clinical problem that often threatens the lives of patients .',
  '1 . Acute lung injury ( ALI ) or acute respiratory distress syndrome is a serious clinical problem with high mortality .',
  '[ Pediatric acute respiratory distress syndrome : a severe problem than yet to be conquered by critical care medicine ] .',
  'Discriminating cardiogenic pulmonary edema ( CPE ) from acute respiratory distress syndrome ( ARDS ) is a serious problem in emergency departments , and the ability of chest radiographs to differentiate between these 2 entities is limited .',
  'Acute respiratory distress syndrome ( ARDS ) represents a serious problem in critically ill patients and is associated with in-hospital mortality rates of 33%-52 % .',
  'Diabetes is a devastating global health problem and is considered a predisposing factor for lung injury progression .',
  'Acute lung injury ( ALI ) is a devastating clinical problem with a mortality as high as 60 % .',
  'Acute respiratory distress syndrome ( ARDS ) remains a serious clinical problem with the main treatment being supportive in the form of mechanical ventilation .',
  'Despite improvements in critical care , acute respiratory distress syndrome ( ARDS ) remains a devastating clinical problem with high rates of morbidity and mortality .',
  'Smoke inhalation leads to acute lung injury ( ALI ) , a devastating clinical problem associated with high mortality rates .',
  'Acute respiratory distress syndrome ( ARDS ) is a serious clinical problem that has a 30 - 50 % mortality rate .',
  'Acute lung injury or acute respiratory distress syndrome is a serious clinical problem with high mortality .',
  'Smoke inhalation leads to acute lung injury ( ALI ) , a devastating clinical problem associated with high mortality .',
  'Acute respiratory distress syndrome ( ARDS ) causes a heterogeneous lung injury and remains a serious medical problem , with one of the only treatments being supportive care in the form of mechanical ventilation .'],
 'cardiac': ['Survival rates of out-of-hospital cardiac arrest remain poor.',
  'Distinction of paroxysmal atrial fibrillation (PAF) from non-PAF is important in clinical practice, but this is often difficult at the time of first documented AF.',
  'Cardiac arrest due to ischaemia is frequently the first manifestation of cardiovascular disease.',
  'Sudden , unexpected death in CHF patients is also a serious problem in Japan .',
  'With an annual incidence of 1 to 2@1000 and a rate of survival without complication of 2 % , sudden death outside hospital constitutes a serious public health problem in France .',
  'Cardiac arrest is a vexing public health problem .',
  'Worldwide , out-of-hospital cardiac arrest ( OHCA ) remains a serious problem .',
  'Looking forward : PACES Task Force on prevention of sudden cardiac death in the young : a comprehensive approach to a preventable problem .',
  'In our population , permanent atrial fibrillation ( pAF ) is a serious concomitant problem in patients scheduled for open heart surgery .',
  'Cardiac tamponade is a life-threatening and time-critical emergency that requires early recognition and prompt management often alongside other resuscitation considerations .',
  'Atrial fibrillation constitutes a serious public health problem because it can lead to complications .',
  'The management of synchronous long-standing persistent atrial fibrillation and pulmonary lesions remains a serious surgical dilemma due to the lack of clinical data and surgical guidelines .',
  'Atrial fibrillation after inhalational lung injury : a troubling complication of a rare problem .',
  'In industrialized countries , sudden cardiac death is a serious public health problem that accounts for about 15 % to 20 % of all deaths , with an incidence of 0.5 to 3 deaths per 100,000 athletes .',
  'Although identification of the HCM patient subset at high risk for a catastrophic event with precision continues to present challenges , treatment strategies for the prevention of sudden death are now available .',
  'BACKGROUND Karoshi , which is sudden death associated with overwork , has become a serious problem in China .',
  'Sudden cardiac death ( SCD ) is a serious public health problem .',
  'Sudden cardiac death ( SCD ) is a serious public health problem ; the annual incidence of out-of-hospital cardiac arrest in North America is approximately 166,200 .',
  'Atrial flutter is a serious problem after surgery for congenital heart disease .',
  'Atrial fibrillation is a serious public health problem posing a considerable burden to not only patients , but the healthcare environment due to high rates of morbidity , mortality , and medical resource utilization .',
  'With more than a third of patients expected to endure the arrhythmia at any given time point , atrial fibrillation after cardiac surgery becomes a vexing problem in the postoperative care of cardiac surgery patients .',
  'Out-of-hospital cardiac arrest remains a serious clinical problem with a survival rate of less than 5 % .',
  'Sudden cardiac death ( SCD ) still remains a serious problem .',
  'Postoperative atrial fibrillation ( AF ) is a vexing problem in cardiac surgery .',
  'Sudden death ( SD ) is a tragic event and a world-wide health problem .',
  'Atrial fibrillation is a serious problem , especially in patients on dialysis .',
  'Low compliance rates with medication after an acute coronary syndrome ( ACS ) is a serious public health problem with adverse socioeconomic implications for both patients and their families as well as for health systems in general .',
  'Cardiac arrhythmia causing sudden cardiac death is a serious worldwide public health problem .',
  'Atrial fibrillation ( AF ) is the most common arrhythmia and has become a serious public health problem .',
  'Supraventricular tachyarrhythmia ( SVT ) such as sinus tachycardia and atrial dysrhythmia is a life-threatening problem in the period immediately following an open-heart operation .',
  'In-hospital cardiac arrest secondary to ventricular dysrhythmias following acute myocardial infarction remains a serious concern for hospital staff .',
  'However , with the increasing age of patients , preexisting disease or trauma , and new surgical interventions cardiac arrests remain a serious concern .',
  'As the first and only manifestation of ischemic heart disease , sudden unexpected cardiac death ( SUCD ) is a serious clinical and epidemiological concern .',
  'Atrial and ventricular dysrhythmias developing after cardiac operation further reduce cardiac output , posing a serious problem for postoperative management .',
  'A device has also been developed for the automatic or semiautomatic treatment of atrial fibrillation , an arrhythmia less life-threatening than ventricular fibrillation , but still a serious health problem .',
  'Permanent atrial fibrillation ( pAF ) is a serious problem in cardiac surgery : An incidence of 3.5 % among all patients scheduled for open heart surgery , 9.8 % in heart valve cases and 45.6 % among patients with severe rheumatic mitral valve ( MV ) disease was observed in our institution .',
  'Pediatric sudden death is a devastating problem worsened by the fact that the death may have been preventable .',
  'During childhood in patients after surgical correction late arrhythmias mostly do not represent a severe problem , but with time , when reaching adulthood , this may be an issue .',
  'SCD remains a serious problem in the Western Countries and although prevention of SCD is one of the main targets in modern cardiology the incidence of SCD has not declined during the past decades .'],
 'scd': ['Survival rates of out-of-hospital cardiac arrest remain poor.',
  'Cardiac arrest due to ischaemia is frequently the first manifestation of cardiovascular disease.',
  'Sudden , unexpected death in CHF patients is also a serious problem in Japan .',
  'With an annual incidence of 1 to 2@1000 and a rate of survival without complication of 2 % , sudden death outside hospital constitutes a serious public health problem in France .',
  'Cardiac arrest is a vexing public health problem .',
  'Worldwide , out-of-hospital cardiac arrest ( OHCA ) remains a serious problem .',
  'Looking forward : PACES Task Force on prevention of sudden cardiac death in the young : a comprehensive approach to a preventable problem .',
  'Cardiac tamponade is a life-threatening and time-critical emergency that requires early recognition and prompt management often alongside other resuscitation considerations .',
  'In industrialized countries , sudden cardiac death is a serious public health problem that accounts for about 15 % to 20 % of all deaths , with an incidence of 0.5 to 3 deaths per 100,000 athletes .',
  'Although identification of the HCM patient subset at high risk for a catastrophic event with precision continues to present challenges , treatment strategies for the prevention of sudden death are now available .',
  'BACKGROUND Karoshi , which is sudden death associated with overwork , has become a serious problem in China .',
  'Sudden cardiac death ( SCD ) is a serious public health problem .',
  'Sudden cardiac death ( SCD ) is a serious public health problem ; the annual incidence of out-of-hospital cardiac arrest in North America is approximately 166,200 .',
  'Out-of-hospital cardiac arrest remains a serious clinical problem with a survival rate of less than 5 % .',
  'Sudden cardiac death ( SCD ) still remains a serious problem .',
  'Sudden death ( SD ) is a tragic event and a world-wide health problem .',
  'Low compliance rates with medication after an acute coronary syndrome ( ACS ) is a serious public health problem with adverse socioeconomic implications for both patients and their families as well as for health systems in general .',
  'Cardiac arrhythmia causing sudden cardiac death is a serious worldwide public health problem .',
  'In-hospital cardiac arrest secondary to ventricular dysrhythmias following acute myocardial infarction remains a serious concern for hospital staff .',
  'However , with the increasing age of patients , preexisting disease or trauma , and new surgical interventions cardiac arrests remain a serious concern .',
  'As the first and only manifestation of ischemic heart disease , sudden unexpected cardiac death ( SUCD ) is a serious clinical and epidemiological concern .',
  'Pediatric sudden death is a devastating problem worsened by the fact that the death may have been preventable .',
  'SCD remains a serious problem in the Western Countries and although prevention of SCD is one of the main targets in modern cardiology the incidence of SCD has not declined during the past decades .'],
 'death': ['Survival rates of out-of-hospital cardiac arrest remain poor.',
  'Cardiac arrest due to ischaemia is frequently the first manifestation of cardiovascular disease.',
  'Sudden , unexpected death in CHF patients is also a serious problem in Japan .',
  'With an annual incidence of 1 to 2@1000 and a rate of survival without complication of 2 % , sudden death outside hospital constitutes a serious public health problem in France .',
  'Cardiac arrest is a vexing public health problem .',
  'Worldwide , out-of-hospital cardiac arrest ( OHCA ) remains a serious problem .',
  'Looking forward : PACES Task Force on prevention of sudden cardiac death in the young : a comprehensive approach to a preventable problem .',
  'Cardiac tamponade is a life-threatening and time-critical emergency that requires early recognition and prompt management often alongside other resuscitation considerations .',
  'In industrialized countries , sudden cardiac death is a serious public health problem that accounts for about 15 % to 20 % of all deaths , with an incidence of 0.5 to 3 deaths per 100,000 athletes .',
  'Although identification of the HCM patient subset at high risk for a catastrophic event with precision continues to present challenges , treatment strategies for the prevention of sudden death are now available .',
  'BACKGROUND Karoshi , which is sudden death associated with overwork , has become a serious problem in China .',
  'Sudden cardiac death ( SCD ) is a serious public health problem .',
  'Sudden cardiac death ( SCD ) is a serious public health problem ; the annual incidence of out-of-hospital cardiac arrest in North America is approximately 166,200 .',
  'Out-of-hospital cardiac arrest remains a serious clinical problem with a survival rate of less than 5 % .',
  'Sudden cardiac death ( SCD ) still remains a serious problem .',
  'Sudden death ( SD ) is a tragic event and a world-wide health problem .',
  'Low compliance rates with medication after an acute coronary syndrome ( ACS ) is a serious public health problem with adverse socioeconomic implications for both patients and their families as well as for health systems in general .',
  'Cardiac arrhythmia causing sudden cardiac death is a serious worldwide public health problem .',
  'In-hospital cardiac arrest secondary to ventricular dysrhythmias following acute myocardial infarction remains a serious concern for hospital staff .',
  'However , with the increasing age of patients , preexisting disease or trauma , and new surgical interventions cardiac arrests remain a serious concern .',
  'As the first and only manifestation of ischemic heart disease , sudden unexpected cardiac death ( SUCD ) is a serious clinical and epidemiological concern .',
  'Pediatric sudden death is a devastating problem worsened by the fact that the death may have been preventable .',
  'SCD remains a serious problem in the Western Countries and although prevention of SCD is one of the main targets in modern cardiology the incidence of SCD has not declined during the past decades .'],
 'breast': ['Tuberous breast (TB) is a rare congenital deformity, which may appear in different clinical forms representing various degrees of a single pathological entity.',
  'Over 90% of women report to be very dissatisfied with the aspect of their breast after bariatric surgery.',
  'Disparities in access to care exist for breast cancer patients, including access to surgeons performing reconstruction.',
  'Breast cancer is the most prevalent cancer among women',
  'Preventable deaths resulting from the scourge of breast cancer has become alarming and worrisome in many societies in developing countries, including Nigeria',
  'Chronic breast cancer-related lymphedema (BCRL) is a potentially serious complication following treatment',
  'A major limitation in counseling unaffected women from families with inherited breast and ovarian cancer is that a " true-negative " interpretation of wild type BRCA analysis of the proband can not be inferred in the absence of demonstration of a BRCA mutation segregating in the kindred .',
  'The number one problem facing older women with breast cancer today is that they are not receiving the same benefits from treatment advances as younger women .',
  'Although early detection of cancer through screening can prevent cancer deaths , a drawback of screening is overdiagnosis .',
  'A drawback of early detection of breast cancer through mammographic screening is the diagnosis of breast cancers that would never have become clinically detected .',
  'By 4 random assignments of villages , data were collected manually ( Group 1 ) , or with the cell-phone program alone ( Group 2 ) or with management algorithms ( Groups 3 and 4 ) , and women adjudged to have a serious breast problem were shown a motivational video ( Group 3 ) , or navigated/accompanied to a breast problem center for evaluation ( Group 4 ) .',
  'Breast cancer represents a serious health concern for women .',
  'Since lymphedema represents a debilitating and progressive problem that is feared by most breast cancer patients and their providers , an up-to-date understanding is necessary in order to better diagnose , treat and manage these patients .',
  'Breast cancer represents a serious public health concern in Hungary .',
  'Breast cancer continues to be a serious public health problem .',
  'Breast cancer represents a serious public health problem worldwide , for its high incidence , morbidity , mortality , and its high cost treatment .',
  'Breast cancer is a serious problem in the developed world , and the common perception of the risks of developing the disease are communicated to the public via a variety of means .',
  'Breast cancer continues to be one of the most common malignancies and is a serious problem particularly in women , although men may also be affected .',
  'Although many studies have explored psychological aspects of this type of surgery , the consistently dramatic increase in numbers of breast augmentations , some that result in adverse psychological outcomes , remains a serious concern for health care providers .',
  "Although 10 - 26 months ' lead time could infer some potential for use of these tumor-associated antigens to help detect malignant neoplasms at an earlier stage , a serious problem of frequent false positives prevents CEA and HCG levels from being useful as cancer-screening tests at this time .",
  'Breast cancer is a serious health problem .',
  'Breast cancer is a troublesome health problem , particularly among underserved and minority women .',
  'This trend represents a serious health care concern because of the potential increased risk of local recurrence and breast cancer mortality .',
  'Breast cancer ( BRCA ) is a serious public health problem , as it is the most frequent malignant tumor in women worldwide .',
  'Breast cancer is the most abundant cancer worldwide and a severe problem for women .',
  'BRCA1 VUSs are frequently found in patients with hereditary breast or ovarian cancer and present a serious problem for clinical geneticists .',
  'Breast cancer is a serious health concern and a disease that is not well understood .',
  'It offers women with early carcinoma of the breast the opportunity to avoid a serious cosmetic , functional and psychologic problem with no increased risk in terms of survival or local control of the neoplasm .',
  'Breast cancer is a heterogeneous disease , and triple-negative breast cancer ( TNBC ) continues to be a serious health problem .',
  "Distant recurrences after antineoplastic treatment remain a serious problem for breast cancer clinical management , which threats patients ' life .",
  'Breast cancer is a serious health problem that preferentially metastasizes to bone .',
  'Breast cancer is a serious medical and social problem , and the ultimate goal should be to promote accessible and financially sustainable high standard healthcare interventions and develop patient-oriented strategies for prevention , diagnosis , and treatment .',
  "High levels of cancer-specific distress were found pre-genetic counselling , with 28 % of participants reporting that they worried about breast cancer ' frequently or constantly ' and 18 % that worry about breast cancer was ' a severe or definite problem ' .",
  'The delay in diagnosis and treatment of breast cancer remains a serious problem .',
  'The incomplete and inefficient extraction of tumors with tris buffer system after only one homogenization and centrifugation is a serious concern in efforts to achieve accurate determinations of receptor concentrations which permit the accurate prediction of hormone responsiveness of breast cancers .',
  'We are thus left with a serious problem , one that must be resolved before we will be able to fully assess our progress in increasing breast and cervical cancer screening .',
  'Breast cancer is a serious problem causing the death of women across the world .',
  'Widespread local recurrence of breast cancer , untreatable by surgery or radiation therapy , can present a serious therapeutic problem predominantly in patients refractory to systemic therapy .',
  'Breast cancer is the most frequent cancer in women , and in recent years it has become a serious public health problem in Colombia .',
  'Cancer recurrence is a serious problem in breast cancer ( BC ) patients , and immunogenic cell death ( ICD ) has been proposed as a strategy to overcome this recurrence .',
  'Although oncological therapies have improved in the last decades , breast cancer ( BC ) remains a serious health problem worldwide .',
  'Metastatic breast cancer is a devastating problem , clinical application of I3C as a potent chemopreventive agent may be helpful in limiting breast cancer invasion and metastasis .',
  'Spontaneous canine mammary tumors constitute a serious clinical problem .',
  'Breast cancer remains a serious public health problem globally .',
  'Breast cancer is a serious health problem worldwide .',
  'Despite male breast cancer is rare in occurrence , it is a serious problem .',
  'Breast cancer is a serious health problem worldwide .',
  "A proportion of cases detected with routine screening would not have progressed to a life-threatening form of breast cancer during the patient 's lifetime , and overdiagnosis of breast cancer is a cause for concern .",
  'Breast cancer is a serious health problem worldwide , representing the second cause of death through malignancies among women in developed countries .',
  'Radical mastectomy results in a severe cosmetic and functional problem for patients .',
  'Metastatic breast cancer remains a serious health concern and numerous investigations recommended medicinal plants as a complementary therapy .',
  'Anxiety after an abnormal screening mammogram is a serious problem .',
  'In this report , we have analyzed the correlation between abnormalities in the RB1CC1 pathway and long-term prognosis , because disease-specific death in later periods ( > 5 years ) of the disease is a serious problem in breast cancer .',
  'However , postoperative breast deformity is a serious problem for patients with breast conserving surgery , which can not be relieved only by shortening or moving the surgical wound .',
  'Breast cancer is the most common female cancer and remains a serious public health concern worldwide .',
  'Breast cancer still represents a serious health problem and is currently the most frequent malignancy in the female population in developed countries .',
  'Lymphoedema is a serious problem for many breast cancer survivors .',
  'Breast cancer in the United States continues to be a serious public health problem that affects individuals , families , and society .',
  'Breast cancer is a common cancer and becomes a severe healthy problem among females .',
  'The already high and still rising mortality rate for breast carcinoma continues to represent a serious problem , especially since neither surgical treatment nor radiotherapy has a significant influence on the prognosis of the disease .',
  'Because canine mammary tumours constitute a serious clinical problem and there are no good prognostic markers ( only histopathological variables are used ) , the aim of the presented study was to find new malignancy markers as well as to identify intracellular pathways and biological processes characteristic for canine mammary malignancy .',
  'Breast cancer poses a serious public health problem , and it is hoped that identification of genetic and environmental factors that contribute to the development of breast cancer will enhance prevention efforts .',
  'Preserving the size and shape of the breast after treatment is beneficial for the patient , and deformity of the residual breast can be a serious problem .',
  'The results of this study showed that breast cancer is becoming a serious epidemiological problem in Poland .',
  'With such a high incidence , breast cancer is a serious health concern for all American women .',
  'Chronic lymphedema is a debilitating complication of cancer diagnosis and therapy and poses many challenges for health care professionals .',
  'Breast cancer remains a serious public health problem that results in the loss of lives among women .',
  'A convenience sample of relevant studies examining CPSP following breast reconstruction reveals inadequate evidence to support a serious concern for reconstruction-induced CPSP and further that these studies fail to adhere to recommended methodological standards to effectively isolate surgery as the etiology of persistent pain reported by women following reconstructive surgery .',
  'Breast cancer is a life-threatening disease in females and the leading cause of mortality among the female population , presenting huge challenges for prognosis and treatment .',
  'The recurrence of breast cancer ( BC ) is a serious therapeutic problem , and the risk factors for recurrence urgently need to be identified .',
  'Breast cancer ( BRCA ) is a serious public health problem , as it is the most frequent malignant tumor in women worldwide .',
  'Breast cancer is a serious health issue and a major concern in biomedical research .',
  'Missense substitutions of uncertain clinical significance in the BRCA1 gene are a vexing problem in genetic counseling for women who have a family history of breast cancer .',
  'The high morbidity and mortality of breast cancer among women is a serious problem .',
  'Lymphoedema is a distressing problem affecting many women after breast cancer surgery .',
  'Triple-negative ( ER-/PR-/HER2- ) breast cancer ( TNBC ) is a severe clinical problem because of its relatively poorer prognosis , aggressive behavior and lack of targeted therapies .',
  '[ Overdiagnosis in mammographic screening a serious problem ] .',
  'Introduction : Currently breast ( BC ) cancer is a serious medical problem in all countries of the world .',
  'Cancer of the breast is a serious public health problem throughout the world .',
  'Breast cancer presents a serious medical and social problem worldwide .',
  'Local recurrence remains a serious problem among patients undergoing breast conservative surgery .',
  'Breast cancer is a severe problem for women around the world especially in developing countries , according to recent reports from the World Health Organization ( WHO ) .',
  'Globally , breast cancer is a serious concern that exhibits a persistent rise in its incidence and related mortality even after significant advancement in the field of cancer research .',
  'Male breast cancer though rare , is a serious clinical problem associated with late presentation .',
  'Currently , mammary neoplasms in female canines are a serious problem in veterinary clinics .',
  'We conclude that late local recurrences after breast conservation do not represent a serious management problem .',
  'Breast cancer continues to be a serious health problem particularly in developed countries .',
  'Painful nipple fissure is a troublesome problem for breastfeeding mothers .',
  'Triple negative breast cancer ( TNBC ) remains a serious health problem with poor prognosis and limited therapeutic options .',
  'Breast cancer is still a serious health problem in 21st century and diagnosis , treatment and prognosis of this malignant disease are subject to many research .'],
 'esophageal': ['Patients with unresectable esophageal cancer require palliation for dysphagia.',
  'This remains a major drawback of esophageal stent therapy .',
  'A major drawback of laser endoscopy in the palliation of malignant dysphagia is the need for repeated treatments .',
  'The diagnosis and treatment of congenital esophageal stenosis ( CES ) can be a vexing clinical problem .',
  'Esophagogastric anastomotic stricture following esophagectomy with a gastric esophageal substitute can be a vexing problem for the patient and treating physician .',
  'Esophageal stenoses , both congenital and acquired , represent a serious problem in childhood due to the deleterious effects , of these anomalies in the patients nutritional state and lifestyle .',
  'The treatment of malignant esophageal stenoses is a serious problem which may have a surgical solution at diagnosis in only a selected number of cases .',
  'The inflammatory complications still remain a serious problem after oesophagectomy with a great portion on postoperative mortality .',
  'Anastomotic stricture causing recurrent dysphagia is a serious problem occurring in patients after total oesophagectomy and cervical oesophagogastrostomy .',
  'Caustic ingestion is a serious medical problem affecting anywhere from 5,000 to 15,000 persons per year .',
  "Caustic stenosis is a serious problem in children due to its complicated resolution and implications in important areas like nutrition , as well as the child 's tolerance to the measures taken to correct them .",
  'Especially patients been operated for head and neck cancer can be a serious problem for the removal of percutaneous endoscopic gastrostomy .',
  'Caustic esophageal burn is a serious problem in pediatric surgery .',
  'Postanesthetic esophageal dysfunction was a debilitating and costly problem that developed in one dog despite current preventative treatment .',
  'Caustic ingestion is a serious medical problem with a variety of clinical presentations and a complicated clinical course .',
  'The complication of TEF secondary to malignancy is a devastating problem that carries a bleak prognosis , but when it is performed promptly after the diagnosis of a malignant TEF , esophageal bypass or stenting improves survival and quality of life for these unfortunate patients .',
  'Although curative resection of esophageal cancer has become a safe procedure , in patients with pulmonary dysfunction , postoperative complications remain a serious problem .',
  'Caustic substance ingestion ( CSI ) is a serious medical problem with potentially devastating short- and long-term consequences .',
  'The ingestion of caustic substances represents a serious problem , often with devastating consequences on the esophagus and the stomach .',
  'Anastomotic leak from cervical esophagogastric anastomoses is a serious problem after esophagectomy .',
  'Cervical esophageal carcinoma has been a vexing problem because of the multicentric nature of the disease , the common advanced stage at presentation ( with invasion of important adjacent structures , especially the trachea or larynx ) , and difficulty in satisfactorily reconstructing pharyngogastric continuity after extensive resection .',
  'Postoperative sarcopenia following esophagectomy for esophageal cancer has become a severe problem due to the increasing number of elderly patients undergoing surgery .',
  'Postoperative malnutrition remains a severe problem after oesophageal cancer resection , even in long-term disease-free survivors .',
  'Corrosive esophageal injury due to accidental ingestion is a serious clinical problem in children particularly in developing countries .',
  'Esophageal leak is a life-threatening problem that can result from spontaneous rupture of the esophagus , cancer , anastomotic dehiscence after surgery , or as a complication of endoscopy .',
  'This rapidly achieved endoscopic palliation represents a major advance in the management of a serious medical problem .',
  'Caustic esophagitis is a serious clinical problem and many agents are currently tried out in many experimental models .',
  "Esophageal stenosis , due to its important implications on the patients ' quality of life , poses a serious problem , often difficult to resolve , that requires therapeutical solutions that could irreversibly affect vital conditions and quality of life of those affected .",
  'Surgical treatment of severe peptic esophageal strictures is a serious problem in high-risk cases .',
  'The ingestion of caustic substances can represent a serious medical problem in children .',
  'Oesophageal strictures developing after caustic ingestion in children are a serious problem , and several protocols to prevent stricture formation have been proposed .',
  'the ingestion of chemical agents , of caustic nature , represents a serious problem for clinical toxicology .',
  'However , anastomotic leakage remains a serious problem for those undergoing esophageal bypass for unresectable carcinoma of the esophagus .'],
 'esophagectomy': ['Patients with unresectable esophageal cancer require palliation for dysphagia.',
  'This remains a major drawback of esophageal stent therapy .',
  'A major drawback of laser endoscopy in the palliation of malignant dysphagia is the need for repeated treatments .',
  'The diagnosis and treatment of congenital esophageal stenosis ( CES ) can be a vexing clinical problem .',
  'Esophagogastric anastomotic stricture following esophagectomy with a gastric esophageal substitute can be a vexing problem for the patient and treating physician .',
  'Esophageal stenoses , both congenital and acquired , represent a serious problem in childhood due to the deleterious effects , of these anomalies in the patients nutritional state and lifestyle .',
  'The treatment of malignant esophageal stenoses is a serious problem which may have a surgical solution at diagnosis in only a selected number of cases .',
  'The inflammatory complications still remain a serious problem after oesophagectomy with a great portion on postoperative mortality .',
  'Anastomotic stricture causing recurrent dysphagia is a serious problem occurring in patients after total oesophagectomy and cervical oesophagogastrostomy .',
  'Especially patients been operated for head and neck cancer can be a serious problem for the removal of percutaneous endoscopic gastrostomy .',
  'Postanesthetic esophageal dysfunction was a debilitating and costly problem that developed in one dog despite current preventative treatment .',
  'The complication of TEF secondary to malignancy is a devastating problem that carries a bleak prognosis , but when it is performed promptly after the diagnosis of a malignant TEF , esophageal bypass or stenting improves survival and quality of life for these unfortunate patients .',
  'Although curative resection of esophageal cancer has become a safe procedure , in patients with pulmonary dysfunction , postoperative complications remain a serious problem .',
  'Anastomotic leak from cervical esophagogastric anastomoses is a serious problem after esophagectomy .',
  'Cervical esophageal carcinoma has been a vexing problem because of the multicentric nature of the disease , the common advanced stage at presentation ( with invasion of important adjacent structures , especially the trachea or larynx ) , and difficulty in satisfactorily reconstructing pharyngogastric continuity after extensive resection .',
  'Postoperative sarcopenia following esophagectomy for esophageal cancer has become a severe problem due to the increasing number of elderly patients undergoing surgery .',
  'Postoperative malnutrition remains a severe problem after oesophageal cancer resection , even in long-term disease-free survivors .',
  'Esophageal leak is a life-threatening problem that can result from spontaneous rupture of the esophagus , cancer , anastomotic dehiscence after surgery , or as a complication of endoscopy .',
  'This rapidly achieved endoscopic palliation represents a major advance in the management of a serious medical problem .',
  "Esophageal stenosis , due to its important implications on the patients ' quality of life , poses a serious problem , often difficult to resolve , that requires therapeutical solutions that could irreversibly affect vital conditions and quality of life of those affected .",
  'Surgical treatment of severe peptic esophageal strictures is a serious problem in high-risk cases .',
  'However , anastomotic leakage remains a serious problem for those undergoing esophageal bypass for unresectable carcinoma of the esophagus .'],
 'osteoporosis': ['30% of myeloma patients suffer from vertebral compression fractures (VCF).',
  'A major problem with osteoporosis in men is that it continues to be unrecognized , and the majority of men with fragility fractures due to osteoporosis are not being treated .',
  'A less appreciated problem with caffeine is that it may increase the risk of osteoporosis and hip fracture .',
  'A potential drawback of gamma-secretase inhibitors was their ability to enhance osteoclastic maturation of normal circulating preosteoclasts induced by RANKL + M-CSF .',
  'A potential drawback of GH replacement therapy in GH deficient ( GHD ) patients is the initial decrease in bone mass .',
  'However , steroid-induced bone loss constitutes a potential drawback of this treatment option .',
  'A major drawback of standard DXA is that the bone mineral density ( BMD ) data can not be used with certainty to predict who will sustain a vertebral fracture .',
  'Osteoporosis is a serious health problem in the U.S. today resulting in premature mortality , deformity , pain , loss of function , and disability .',
  'Osteoporosis is a serious clinical problem that often follows the accelerated bone loss that occurs after the estrogen withdrawal of menopause .',
  'Glucocorticoid (GC)-induced osteoporosis and fractures have become a serious problem for Eastern Asians .',
  'The most serious complication of osteoporosis is bone fractures , especially fractures of the proximal femur , which are a serious medical and social problem .',
  'Osteoporosis in men is a disease that is increasing in incidence , and with an increasing elderly population it poses a serious health problem .',
  'Diabetic osteoporosis is a severe public health concern in the world .',
  'Osteoporosis is a serious health problem affecting more than 200 million elderly people worldwide .',
  'Syndromes of bone disease and deformities consequent to disorders of nutrition , bone and mineral metabolism constitute a serious national health problem .',
  'Osteoporosis is a serious global health problem for the future , that is why improving diagnostic methods and prevention of this disease could be helpful .',
  'Osteoporosis has rapidly evolved into a severe health threat to Americans and a major public health problem .',
  'Fragility fractures represent a serious social and economic problem ; the diagnosis of osteoporosis is an unachieved target by orthopaedic surgeons , despite the chance to detect it in many clinical assets and the availability of effective treatment tools .',
  'Osteoporosis is a serious worldwide public health concern .',
  'The prevention of fragility fractures in patients with sarcoidosis is a serious concern and the potential risk of hypercalcemia limits vitamin D and calcium supplementation .',
  'Recently , the incidence of osteoporosis and its related fracture are increasing as the aging of population has been progressing in most developed countries , becoming a serious medical and social problem .',
  'Estrogen deficiency osteoporosis has become a serious problem in elderly women .',
  'Osteoporosis , mainly characterised by low bone mineral density ( BMD ) , is a serious public health problem .',
  'Diabetic osteoporosis has become a severe public health problem in the aging societies .',
  'Osteoporosis is a serious public health problem and icariin ( ICA ) is the active component of the Epimedium \xa0 sagittatum , a traditional Chinese medicinal herb .',
  'Osteoporosis is a severe health problem causing bone fragility and consequent fracture .',
  'Osteoporosis , a multifaceted bone disorder , is considered as a serious health problem throughout the world and the magnitude of diseased patients is increasing day by day .',
  'The compromised capacity of bone healing in osteoporotic population renders a serious concern of patients and clinicians .',
  'Osteoporosis was a serious health concern that most commonly affected women .',
  'Osteoporosis is a skeletal disease mainly affecting women over 50 years old and it represents a serious public health problem because of the high socioeconomic burden .',
  'Post-menopausal osteoporosis has become a serious public health problem with the increase of the geriatric population .',
  'Focal bone loss around inflamed joints in patients with autoimmune disease , such as rheumatoid arthritis , remains a serious clinical problem .',
  'Osteoporosis is a serious health problem worldwide .',
  'Osteoporosis is a serious health problem for men .',
  "Osteoporosis , a debilitating disease caused by an imbalance between the action of osteoblasts and osteoclasts , is becoming an increasing problem in today 's aging population .",
  'Progression of osteoporosis and bone fracture in aging male populations is a serious concern not only as medical aspect but also as administrative issue in the developed nations where aging peoples has been increasing .',
  'Osteoporosis constitutes a serious health problem in old people .',
  'As osteoporosis is a serious health problem , a large number of studies focus on elucidating the aetiology of the disease as well as on the identification of novel therapeutic targets for the treatment of osteoporotic patients .',
  'These results indicated that clenbuterol induced the muscular hypertrophy but inhibited the longitudinal growth of bones in young male rats , which may be a serious concern in any ergogenic use .',
  'Osteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide , with severe consequences including vertebral fractures that are associated with significant morbidity and mortality .',
  'Bone loss is a serious clinical problem that is frequently accompanied by chronic inflammation , illustrating that there is a convoluted relationship between inflammation and bone erosion .',
  'Osteoporosis ( OP ) is a serious health problem that contributes to osteoporotic structural damage and bone fragility .',
  'Osteoporosis is a serious health problem among postmenopausal women .',
  "Osteoporosis and pathological bone fractures which are its consequences are a serious health problem of today 's world .",
  'Osteoporosis , which has become a serious public health concern , is influenced by diet , especially calcium intake .',
  'Osteoporosis is a serious health problem of endemic proportions in the United States .',
  'Osteoporosis is a serious problem , since about 50 % of women over the age of 50 suffer at least one osteoporotic fracture .',
  'In free-text fields , GPs reported most frequently that budgetary restrictions preventing the prescription of appropriate medication represented a severe problem for osteoporosis management .',
  'On the other hand , bone destruction was a serious problem among a minority of " risk " individuals after the age of 40 .',
  'Decreased bone density ( osteoporosis and osteomalacia ) is a serious problem for celiacs .',
  'Vertebral compression fractures represent a serious health care problem .',
  'Bone diseases such as osteoarthritis , osteoporosis , and bone tumor present a severe public health problem .',
  'Since the mid-1980s , postmenopausal osteoporosis ( PMO ) has been considered a serious public health concern because of the associated fractures .',
  'Osteoporosis is a serious medical problem because of its complications , most frequently manifesting itself in spine fractures , fractures of distal sections of the forearm and , in later periods of life , hip fractures .',
  'Osteoporosis is a serious health problem in both Caucasians and Asians .',
  'Osteoporosis had become a serious public health problem among the elderly , bringing about the increase of economic burden all over the world both on social healthcare and families of the patients .',
  'Osteoporosis is a serious public health problem , leading to significant mortality not only in aging females but also in males .',
  'Postmenopausal osteoporosis is a serious health problem , and additional treatments are needed .',
  'Among the side-effects caused by steroids , non-traumatic osteonecrosis of the femoral head ( ONF ) constitutes a serious problem .',
  'Glucocorticoids-induced osteoporosis is a serious problem for patients with systemic autoimmune disease requiring relatively long-term glucocorticoid treatment .',
  'Osteoporosis , the most common metabolic bone disease , is a devastating problem and an increasingly major public health issue .',
  'As the population rapidly ages , osteoporosis has been a serious problem .',
  'Osteoporosis is a serious health problem that worsens the quality of life and the survival rate of individuals with this disease on account the osteoporotic fractures .',
  'Osteoporosis and related fragility fractures represent a serious and global public health problem .',
  'Low bone mineral density ( BMD ) is a silent disease that can lead to osteoporosis and is a serious health problem worldwide .',
  'The high worldwide prevalence of osteoporosis means it is considered a serious public health concern , possibly leading to physical disability and an increased mortality rate .',
  'Osteoporotic fractures are a debilitating and a frequently fatal health problem for older adults .',
  'Aging-related osteoporosis ( OP ) is considered a serious public health concern .',
  'In the past , osteoporosis was a serious health concern that most commonly affected women in Northern Europe and the United States of America , but was less commonly seen in Asian women .',
  'As a result of population ageing worldwide , osteoporotic fractures are becoming a serious problem in the western world .',
  'The prevalence of osteoporosis amongst patients with primary biliary cirrhosis ( PBC ) is high and may be a serious clinical problem .',
  'Osteoporosis is a serious national and global public health problem , but data on bone health are limited for Asian women living in the U.S. , the majority of whom are Chinese .',
  'Osteoporosis is a serious public health problem that causes at least 1.3 million fractures and costs more than $ 6 billion annually .',
  'Osteoporosis is a serious health concern affecting millions of Americans , with many patients going undiagnosed and untreated .',
  'Osteoporosis represents a serious health problem worldwide associated with an increased risk of fractures and mortality .',
  'CONTEXT : Low bone mineral density ( BMD ) is a serious public health problem .',
  'Osteoporosis is a serious health problem worldwide and leads to a significant burden on society .',
  'Osteoporosis is a serious health problem for women over 45 years of age .',
  'Bone diseases are a serious problem in modern human life .',
  'Bone loss is a serious health problem .',
  "By the impact of demographic changes and as the result of the ' incorrect ' lifestyles pursued in developed societies , osteoporosis has become a serious social problem .",
  'Osteoporosis is a serious health problem worldwide .',
  '" Osteoporosis and the consequences of compromised bone strength -- particularly vertebral and hip fractures -- are a significant cause of frailty , and increased morbidity and even mortality and hence are a serious and costly public health problem in the elderly population .',
  'Osteoporosis is a serious health problem worldwide that is associated with an increased risk of fractures and mortality .',
  'Vertebral fractures , are a serious clinical problem for elderly osteoporotic patients , have been increasingly recognized and are now common .',
  'For the radiation oncologist in an emergency situation with acute progressive paraplegia distinguishing between benign versus malignant vertebral compression fracture without known malignoma may cause a severe diagnostic problem , when a rapid therapeutic decision is required .',
  'For long-term treatment , the development of osteoporosis is a serious problem .',
  'Glucocorticoid is effective medicines for the treatment of , such as , collagen diseases , pulmonary diseases , skin diseases , organ transplantation , however , glucocorticoid induced osteoporosis have been a serious problem .',
  'Osteoporosis is a serious health concern , particularly in aged societies .',
  'Steroid-induced osteoporosis ( SIO ) is a serious complication of long-term steroid therapy and is of particular concern in growing children .',
  'Glucocorticoid-induced osteoporosis ( GIOP ) is a serious problem for patients with rheumatic diseases requiring long-term glucocorticoid treatment .',
  'Painful fractures of the spine pose a serious clinical problem which gains in importance with the increasing ageing of our population .',
  'Osteoporosis , due to its prevalence worldwide , is a serious health problem .',
  'In this study , these functions of MLT have been investigated in rat bone ( femur ) and in human adipose MSC ( hMSC ) during chronic exposure to low-grade cadmium ( Cd ) toxicity , a serious public health concern .',
  'Osteoporosis is a serious health problem characterized by decreased bone mineral density and deterioration of bone microarchitecture .',
  'Osteoporosis is a serious national public health problem , and is expected to increase significantly over the next few decades , especially in women .',
  'Osteoporosis represents a serious health problem worldwide and is associated with an increased risk for fractures and mortality .',
  'Osteoporosis is a serious public health problem characterized by low bone density and deterioration of the bone microarchitecture .',
  'Subsequent loss of augmentation properties during follow-up is a serious problem of kyphoplasty using injectable CPC in osteoporotic vertebral compression fractures .',
  'It is a serious health problem showing the predisposed person with increased bone fracture risk .',
  'Osteoporosis is a serious health problem that diminishes quality of life and levies a financial burden on those who fear and experience bone fractures .',
  'Glucocorticoid (GC)-induced osteoporosis ( GIO ) is a serious problem for patients taking GC therapy .',
  'Sometimes osteoporosis can be diagnosed with fractures or with a serious health problem , and most women are probably unaware of the risk factors which can be changed by prevention .',
  'It is possible to avoid developing a serious osteoporosis and having bone fracture if we realise the problem at the proper time and take the risk factors into consideration .',
  'Osteoporosis is a serious public health problem , and dietary interventions may potentially be helpful in preventing this disorder .',
  'Osteoporosis is a serious problem worldwide ; it is characterized by bone fractures in response to relatively mild trauma .',
  'Glucocorticoid induced osteopenia is also a serious clinical problem in patients with various nonrenal diseases and can be prevented , or at least attenuated , by pamidronate and other bisphosphonates .',
  'Osteoporosis is a serious public health concern .',
  'Osteoporosis has increased and developed into a serious public health concern worldwide .',
  'It is essential to evaluate osteoporosis risk factors , mainly the modifiable , like the lifestyle , in Mexican women in order to prevent it , since it is a serious public health problem .',
  'Osteoporosis is a serious health problem in the population , mainly for postmenopausal women .',
  'Bone mineral content ( BMC ) and/or bone mineral density ( BMD , i.e. BMC scaled by bone size ) are major determinants for osteoporosis , which is a serious health problem .',
  'Because of its high prevalence worldwide , osteoporosis is considered a serious public health concern .',
  'Osteoporosis is a serious public health concern .',
  'Osteoporotic vertebral compression fractures ( OVCFs ) have gradually evolved into a serious health care problem globally .',
  'Osteoporosis is a serious public health concern worldwide , and community-based public health programs that increase osteoporosis preventive behaviors are ideal to combat this major public health issue .',
  'Osteoporosis in the elderly is a serious problem that is increasing as the population ages .',
  'Osteoporosis is a serious public health concern worldwide .',
  'Osteoporosis has become a serious health problem throughout the world which is associated with an increased risk of bone fractures and mortality among the people of middle to old ages .',
  'Osteoporosis is a serious health problem that has reached epidemic proportions among Canadian women .'],
 'fractures': ['30% of myeloma patients suffer from vertebral compression fractures (VCF).',
  'Femoral head necrosis is a progressive disease that can progress within a relatively short time',
  'Slipped capital femoral epiphysis (SCFE) is a frequent disorder of the adolescent hip, which may lead to avascular necrosis (AVN) of the femoral head, chondrolysis and early osteoarthritis due to the post-slip deformity of the proximal femur',
  'A major problem with osteoporosis in men is that it continues to be unrecognized , and the majority of men with fragility fractures due to osteoporosis are not being treated .',
  'A less appreciated problem with caffeine is that it may increase the risk of osteoporosis and hip fracture .',
  'To his consternation , as he tried to demonstrate the possibility of restorative treatments , Senn found the fundamental problem with hip fractures was that the empiricism of current clinical methods created and perpetuated their own therapeutic justifications .',
  'A potential drawback of gamma-secretase inhibitors was their ability to enhance osteoclastic maturation of normal circulating preosteoclasts induced by RANKL + M-CSF .',
  'A potential drawback of GH replacement therapy in GH deficient ( GHD ) patients is the initial decrease in bone mass .',
  'A major drawback of standard DXA is that the bone mineral density ( BMD ) data can not be used with certainty to predict who will sustain a vertebral fracture .',
  'Osteoporosis is a serious health problem in the U.S. today resulting in premature mortality , deformity , pain , loss of function , and disability .',
  'Osteoporosis is a serious clinical problem that often follows the accelerated bone loss that occurs after the estrogen withdrawal of menopause .',
  'Fracture of the femoral shaft after hip arthroplasty is a serious problem .',
  'The most serious complication of osteoporosis is bone fractures , especially fractures of the proximal femur , which are a serious medical and social problem .',
  'Osteoporotic hip fracture ( HF ) is a serious global public health problem associated with high morbidity and mortality .',
  'Osteoporosis in men is a disease that is increasing in incidence , and with an increasing elderly population it poses a serious health problem .',
  'Hip fractures in Italy are a serious medical problem and a leading health-cost driver .',
  'Hip fracture in the elderly is a serious problem , and solutions to prevent falls are needed .',
  'Non-union of fractured neck of femur in young adults is a serious problem .',
  'Diabetic osteoporosis is a severe public health concern in the world .',
  'Osteoporosis is a serious health problem affecting more than 200 million elderly people worldwide .',
  'Syndromes of bone disease and deformities consequent to disorders of nutrition , bone and mineral metabolism constitute a serious national health problem .',
  'Osteoporosis is a serious global health problem for the future , that is why improving diagnostic methods and prevention of this disease could be helpful .',
  'Despite advances in the field of orthopedic surgery , necrosis of the femoral head still remains a serious problem .',
  'Osteoporosis has rapidly evolved into a severe health threat to Americans and a major public health problem .',
  "The number of hip fracture surgeries exhibit an increasing trend due to the aging of the world 's population and it is expected to become a serious public health problem in the future .",
  'Fracture of the hip is a serious and frequent problem in elderly women , often resulting in a considerable loss of function and an increased mortality long after the initial episode .',
  'Hip fracture is a serious health problem and textural methods are being developed to assess bone quality .',
  'Fragility fractures represent a serious social and economic problem ; the diagnosis of osteoporosis is an unachieved target by orthopaedic surgeons , despite the chance to detect it in many clinical assets and the availability of effective treatment tools .',
  'Osteoporosis is a serious worldwide public health concern .',
  'Hip fractures have become a severe public health problem , especially in very elderly patients .',
  'Although all fractures are a serious setback for the elderly person , those that do not heal properly require special considerations and the mobilization of many resources if the patient is to remain out of an institution .',
  'The prevention of fragility fractures in patients with sarcoidosis is a serious concern and the potential risk of hypercalcemia limits vitamin D and calcium supplementation .',
  'Recently , the incidence of osteoporosis and its related fracture are increasing as the aging of population has been progressing in most developed countries , becoming a serious medical and social problem .',
  'Estrogen deficiency osteoporosis has become a serious problem in elderly women .',
  'At the 2-year follow-up he had a serious mobilisation problem with avascular necrosis of one hip .',
  'Proximal femoral ( hip ) fractures are the leading cause of hospitalization for injuries among older persons and constitute a serious health problem .',
  'Osteoporosis , mainly characterised by low bone mineral density ( BMD ) , is a serious public health problem .',
  'Diabetic osteoporosis has become a severe public health problem in the aging societies .',
  'Pelvis ring fractures of geriatric patients are currently a serious problem in orthopedic and trauma surgery .',
  'Osteoporosis is a serious public health problem and icariin ( ICA ) is the active component of the Epimedium \xa0 sagittatum , a traditional Chinese medicinal herb .',
  'Osteoporosis is a severe health problem causing bone fragility and consequent fracture .',
  'Osteoporosis , a multifaceted bone disorder , is considered as a serious health problem throughout the world and the magnitude of diseased patients is increasing day by day .',
  'Displacements of bone fragments in articular calcaneal fractures visualized radiographically by the changes of Harnroongroj et al. angle do not constitute a serious surgical problem and are easily repositioned and stabilized , as opposed to displacements resulting in changes in the value of the Böhler angle .',
  'The compromised capacity of bone healing in osteoporotic population renders a serious concern of patients and clinicians .',
  'Osteoporosis was a serious health concern that most commonly affected women .',
  'Osteoporosis is a skeletal disease mainly affecting women over 50 years old and it represents a serious public health problem because of the high socioeconomic burden .',
  'Post-menopausal osteoporosis has become a serious public health problem with the increase of the geriatric population .',
  'Canine hip dysplasia ( CHD ) is a serious and common musculoskeletal disease of pedigree dogs and therefore represents both an important welfare concern and an imperative breeding priority .',
  'Osteoporosis is a serious health problem worldwide .',
  'Osteoporosis is a serious health problem for men .',
  'Severe bone deficiency in total hip arthroplasty ( THA ) represents a serious problem , and there is an increasing demand for reconstructive measurements even on the femoral side to salvage these hips .',
  'Osteonecrosis of the femoral head is a serious orthopedic problem .',
  'Hip instability leading to subluxation or dislocation is a serious problem in children suffering from CP and is usually worse in severe condition .',
  'Treatment of the above fractures is not always simple and represents a serious problem in everyday traumatological practice .',
  'High energy pelvic ring disruption represents a serious clinical problem with an overall reported mortality rate of approximately 10 % ( 1 ) .',
  'The fractures of hip joint considered as a serious problem in public health in the medical and socioeconomic issues , the incidence of the fracture neck femur is significantly increased with the increment of general population life span .',
  "Osteoporosis , a debilitating disease caused by an imbalance between the action of osteoblasts and osteoclasts , is becoming an increasing problem in today 's aging population .",
  'Hip fracture , the most dramatic complication of osteoporosis , constitutes a serious health problem of the elderly , with great socioeconomic consequences .',
  'Progression of osteoporosis and bone fracture in aging male populations is a serious concern not only as medical aspect but also as administrative issue in the developed nations where aging peoples has been increasing .',
  'Osteoporosis constitutes a serious health problem in old people .',
  'Femoral neck fracture is a frequently occurring and dangerous disease of elderly patient , whose morbidity is increasing gradually with the aging of population and has become a serious social problem .',
  'Distal radius fractures are a serious clinical problem .',
  'Fracture of the hip constitutes a serious social/health care problem with very little information concerning incidence in Spain being available .',
  'As osteoporosis is a serious health problem , a large number of studies focus on elucidating the aetiology of the disease as well as on the identification of novel therapeutic targets for the treatment of osteoporotic patients .',
  'Hip fractures constitute a serious and common health problem from both individual and public health perspectives .',
  'Osteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide , with severe consequences including vertebral fractures that are associated with significant morbidity and mortality .',
  'Traumatic separation of the proximal femoral epiphysis in children is a serious and as yet unresolved problem .',
  'Non-healing fractures constitute a serious clinical problem .',
  'Bone loss is a serious clinical problem that is frequently accompanied by chronic inflammation , illustrating that there is a convoluted relationship between inflammation and bone erosion .',
  'Osteoporosis ( OP ) is a serious health problem that contributes to osteoporotic structural damage and bone fragility .',
  'Osteoporosis is a serious health problem among postmenopausal women .',
  "Osteoporosis and pathological bone fractures which are its consequences are a serious health problem of today 's world .",
  'Osteoporosis , which has become a serious public health concern , is influenced by diet , especially calcium intake .',
  'Hip fractures are a serious health problem all over the world with grave consequences for the people and health systems involved .',
  'Treatment of unstable pelvic fractures in children is a serious surgical problem .',
  'Dislocation is a serious and common complication and a great concern with the use of total hip arthroplasty ( THA ) when treating displaced femoral neck fracture ( FNF ) .',
  'Hip fracture is a serious public health problem .',
  'Osteoporosis is a serious health problem of endemic proportions in the United States .',
  'Fractures of the ipsilateral femur after hip arthroplasty are a serious problem .',
  'Osteoporosis is a serious problem , since about 50 % of women over the age of 50 suffer at least one osteoporotic fracture .',
  'Proximal femoral fractures in elderly patients are a serious problem in the aging society .',
  'Nonunions of the femoral shaft represent a treatment challenge for the orthopaedic surgeon and a serious socioeconomic problem for the patient .',
  'In free-text fields , GPs reported most frequently that budgetary restrictions preventing the prescription of appropriate medication represented a severe problem for osteoporosis management .',
  'PURPOSE OF THE STUDY Fragility fractures of the pelvic ring in the elderly population are a serious problem in orthopaedics .',
  'On the other hand , bone destruction was a serious problem among a minority of " risk " individuals after the age of 40 .',
  'Pertrochanteric fractures currently represent a serious public health problem for which costs are definitely going to grow in the near future .',
  'Decreased bone density ( osteoporosis and osteomalacia ) is a serious problem for celiacs .',
  'Vertebral compression fractures represent a serious health care problem .',
  'Bone diseases such as osteoarthritis , osteoporosis , and bone tumor present a severe public health problem .',
  'Since the mid-1980s , postmenopausal osteoporosis ( PMO ) has been considered a serious public health concern because of the associated fractures .',
  'Osteoporosis is a serious medical problem because of its complications , most frequently manifesting itself in spine fractures , fractures of distal sections of the forearm and , in later periods of life , hip fractures .',
  'Osteoporosis is a serious health problem in both Caucasians and Asians .',
  'Hip fracture in elderly patients is a serious health concern due to the associated morbidity and mortality .',
  'Osteoporosis had become a serious public health problem among the elderly , bringing about the increase of economic burden all over the world both on social healthcare and families of the patients .',
  'Osteoporosis is a serious public health problem , leading to significant mortality not only in aging females but also in males .',
  'Both hip fractures and cardiovascular diseases represent in Italy a serious medical problem and a leading health cost driver , according to what has already been reported for many other Countries in the industrialized world , thus requiring a global clinical approach .',
  'Postmenopausal osteoporosis is a serious health problem , and additional treatments are needed .',
  'Osteoporosis , the most common metabolic bone disease , is a devastating problem and an increasingly major public health issue .',
  'As the population rapidly ages , osteoporosis has been a serious problem .',
  'Osteoporosis is a serious health problem that worsens the quality of life and the survival rate of individuals with this disease on account the osteoporotic fractures .',
  'Osteoporosis and related fragility fractures represent a serious and global public health problem .',
  'Low bone mineral density ( BMD ) is a silent disease that can lead to osteoporosis and is a serious health problem worldwide .',
  'The high worldwide prevalence of osteoporosis means it is considered a serious public health concern , possibly leading to physical disability and an increased mortality rate .',
  'Osteoporotic fractures are a debilitating and a frequently fatal health problem for older adults .',
  'Aging-related osteoporosis ( OP ) is considered a serious public health concern .',
  'The treatment of fractures of the tibial plateau or distal femur often represents a severe problem in geriatric patients .',
  'Fractures of the femoral bone shaft during and after hip arthroplasty are a serious clinical problem .',
  'In the past , osteoporosis was a serious health concern that most commonly affected women in Northern Europe and the United States of America , but was less commonly seen in Asian women .',
  'As a result of population ageing worldwide , osteoporotic fractures are becoming a serious problem in the western world .',
  'The prevalence of osteoporosis amongst patients with primary biliary cirrhosis ( PBC ) is high and may be a serious clinical problem .',
  'Osteoporosis is a serious national and global public health problem , but data on bone health are limited for Asian women living in the U.S. , the majority of whom are Chinese .',
  'Osteoporosis is a serious public health problem that causes at least 1.3 million fractures and costs more than $ 6 billion annually .',
  'The proximal femoral fracture in the elderly is a serious public health problem .',
  'The fixation of osteosynthesis screws remains a severe problem for fracture repair among osteoporotic patients .',
  'Low-energy fractures are a serious health problem in all countries with the highest incidence in Kazakhstan and Russia .',
  'Osteoporosis is a serious health concern affecting millions of Americans , with many patients going undiagnosed and untreated .',
  'Hip fractures in the elderly are a serious problem for the health service due to the high rate of complications .',
  'Persistent instability after hip revision is a serious problem .',
  'Osteoporosis represents a serious health problem worldwide associated with an increased risk of fractures and mortality .',
  'As in the femoral head , osteonecrosis is a serious problem after injury to the talus .',
  'CONTEXT : Low bone mineral density ( BMD ) is a serious public health problem .',
  'Osteoporosis is a serious health problem worldwide and leads to a significant burden on society .',
  'Osteoporosis is a serious health problem for women over 45 years of age .',
  'Bone diseases are a serious problem in modern human life .',
  'Periprosthetic femoral fractures ( PFF ) actually represent a serious public health problem .',
  'Hip fracture constitutes a serious healthcare problem in Chile , and efforts for the prevention and management of osteoporosis are needed .',
  'Proximal humeral fractures in four or even only three parts , with metaphyseal hinge distances of < 8 \xa0 mm , represent a serious and widely debated problem .',
  'Bone loss is a serious health problem .',
  "By the impact of demographic changes and as the result of the ' incorrect ' lifestyles pursued in developed societies , osteoporosis has become a serious social problem .",
  'Osteoporosis is a serious health problem worldwide .',
  'Nonunion after distal radius fracture is a serious problem and the functional prognosis is doubtful .',
  'Dislocation remains a serious concern for total hip arthroplasty ( THA ) .',
  '" Osteoporosis and the consequences of compromised bone strength -- particularly vertebral and hip fractures -- are a significant cause of frailty , and increased morbidity and even mortality and hence are a serious and costly public health problem in the elderly population .',
  'Hip fracture is a devastating health-care problem in a geriatric patient , leading to high mortality and morbidity .',
  'Elderly hip fracture is becoming a serious problem of public health .',
  'Patients with combined pelvic and acetabular fractures represent a serious injury that includes the resuscitative challenges of pelvic injuries coupled with the difficulties of precise reduction of acetabular fractures .',
  'Osteoporosis is a serious health problem worldwide that is associated with an increased risk of fractures and mortality .',
  'Vertebral fractures , are a serious clinical problem for elderly osteoporotic patients , have been increasingly recognized and are now common .',
  'For the radiation oncologist in an emergency situation with acute progressive paraplegia distinguishing between benign versus malignant vertebral compression fracture without known malignoma may cause a severe diagnostic problem , when a rapid therapeutic decision is required .',
  'For long-term treatment , the development of osteoporosis is a serious problem .',
  'Fractures of the proximal segment of the femur occurring most commonly in elderly patients are a serious , both medical ( orthopaedic ) and socioeconomic , problem .',
  'Osteoporosis is a serious health concern , particularly in aged societies .',
  'Open pelvic fractures are rare but represent a serious clinical problem with high mortality rates .',
  'Open fractures , especially III grade open fractures of the tibial diaphysis , according to the Gustilo classification still remains a serious therapeutic problem .',
  'Paralytic dislocation of the hip in adolescence is not typical , but presents a serious problem whether diagnosed primarily in adolescence or due to the lack of treatment or failed treatment in earlier age .',
  'Study of non-hip fractures , which are a serious public health problem for persons greater than or equal to 65 years of age , has been hindered by the absence of an economical method for case identification .',
  'Painful fractures of the spine pose a serious clinical problem which gains in importance with the increasing ageing of our population .',
  'Osteoporosis , due to its prevalence worldwide , is a serious health problem .',
  'In this study , these functions of MLT have been investigated in rat bone ( femur ) and in human adipose MSC ( hMSC ) during chronic exposure to low-grade cadmium ( Cd ) toxicity , a serious public health concern .',
  'Osteoporosis is a serious health problem characterized by decreased bone mineral density and deterioration of bone microarchitecture .',
  'Osteoporosis is a serious national public health problem , and is expected to increase significantly over the next few decades , especially in women .',
  'Osteoporosis represents a serious health problem worldwide and is associated with an increased risk for fractures and mortality .',
  'Osteoporosis is a serious public health problem characterized by low bone density and deterioration of the bone microarchitecture .',
  'Subsequent loss of augmentation properties during follow-up is a serious problem of kyphoplasty using injectable CPC in osteoporotic vertebral compression fractures .',
  'It is a serious health problem showing the predisposed person with increased bone fracture risk .',
  'Osteoporosis is a serious health problem that diminishes quality of life and levies a financial burden on those who fear and experience bone fractures .',
  'Sometimes osteoporosis can be diagnosed with fractures or with a serious health problem , and most women are probably unaware of the risk factors which can be changed by prevention .',
  'Femoral fracture after TKR is a serious and relatively common problem , but to the best of our knowledge , only one case of femoral condylar fracture after UKA has been reported thus far .',
  'The distal articular femur fracture is a serious injury that for years has been a problem in traumatology .',
  'Hip fracture in the elderly is considered to be a serious sanitary problem .',
  'It is possible to avoid developing a serious osteoporosis and having bone fracture if we realise the problem at the proper time and take the risk factors into consideration .',
  'Osteoporosis is a serious public health problem , and dietary interventions may potentially be helpful in preventing this disorder .',
  'Dislocation of the hip in cerebral palsy remains a serious problem , and prevention is important .',
  'Osteoporosis is a serious problem worldwide ; it is characterized by bone fractures in response to relatively mild trauma .',
  'Fat embolism syndrome ( FES ) is a serious clinical problem in patients suffering from long bone fractures .',
  'Osteoporosis is a serious public health concern .',
  'Avascular necrosis of the hip is a serious clinical problem encountered by primary care physicians .',
  'Unstable intertrochanteric fractures of the hip , especially reverse oblique fractures are a serious problem in traumatology , as there is no standard method of treatment and inadequate treatment carries a significant complication rate .',
  'Osteoporosis has increased and developed into a serious public health concern worldwide .',
  'It is essential to evaluate osteoporosis risk factors , mainly the modifiable , like the lifestyle , in Mexican women in order to prevent it , since it is a serious public health problem .',
  'Osteoporosis is a serious health problem in the population , mainly for postmenopausal women .',
  'Ectopic bone formation following operations of the hip is a severe problem in traumatology and orthopedic surgery by reason of its high morbidity .',
  'Differentiation between traumatic and vascular aseptic bone-necrosis is a serious problem in everyday practice .',
  'Bone mineral content ( BMC ) and/or bone mineral density ( BMD , i.e. BMC scaled by bone size ) are major determinants for osteoporosis , which is a serious health problem .',
  'Because of its high prevalence worldwide , osteoporosis is considered a serious public health concern .',
  'Osteoporosis is a serious public health concern .',
  'Hip fractures constitute a serious healthcare problem in Ukraine , and changes in healthcare are required to improve the management and long-term care of osteoporosis and its complications .',
  'Osteoporotic vertebral compression fractures ( OVCFs ) have gradually evolved into a serious health care problem globally .',
  'Thus , the combination of DM and fracture is becoming a serious health problem worldwide .',
  'Osteoporosis is a serious public health concern worldwide , and community-based public health programs that increase osteoporosis preventive behaviors are ideal to combat this major public health issue .',
  'Osteoporosis in the elderly is a serious problem that is increasing as the population ages .',
  'Osteoporosis is a serious public health concern worldwide .',
  'Hip fracture is a serious health problem among older adults and often results in serious consequences such as disabilities .',
  'Femoral shaft fractures after total hip arthroplasty ( THA ) remain a serious problem , since there is no optimal surgical repair method .',
  'Osteoporosis has become a serious health problem throughout the world which is associated with an increased risk of bone fractures and mortality among the people of middle to old ages .',
  'Osteoporosis is a serious health problem that has reached epidemic proportions among Canadian women .'],
 'anxiety': ['Research to date has focused on the detrimental effects of negative self-images for individuals with social anxiety disorder (SAD), but the benefits of positive self-images have been neglected.',
  'Work attention in employees with schizophrenia is a significant issue in vocational rehabilitation',
  'Mental health issues pose a serious concern in the workplace for the huge productivity loss and financial burden associated with it .',
  'We describe the successful measures taken by State health workers to counteract the anxiety which itself constituted a serious public health problem .',
  'Return of fear is a serious problem in exposure-based treatments of anxiety disorders .',
  'A growing portion of the population is exposed to emotional stress that results in a high incidence of anxiety disorders , a serious social problem .',
  'Anxiety disorders are among the most common of all mental disorders and , when coupled with an awareness of the disability and reduced quality of life they convey , they must be recognized as a serious public health problem .',
  'Music performance anxiety ( MPA ) , or stage fright in music performance , is a serious problem for many musicians , because performance impairment accompanied by MPA can threaten their career .',
  'Although the exact diagnostic boundaries for social phobia are difficult to determine , it can be concluded that social anxiety is a distressing problem for a considerable proportion of the general population .',
  'Panic disorder is a serious societal health problem with large consequences , and it affects primarily psychological and role domains .'],
 'music': ['Research to date has focused on the detrimental effects of negative self-images for individuals with social anxiety disorder (SAD), but the benefits of positive self-images have been neglected.',
  'Work attention in employees with schizophrenia is a significant issue in vocational rehabilitation',
  'Mental health issues pose a serious concern in the workplace for the huge productivity loss and financial burden associated with it .',
  'We describe the successful measures taken by State health workers to counteract the anxiety which itself constituted a serious public health problem .',
  'Return of fear is a serious problem in exposure-based treatments of anxiety disorders .',
  'A growing portion of the population is exposed to emotional stress that results in a high incidence of anxiety disorders , a serious social problem .',
  'Anxiety disorders are among the most common of all mental disorders and , when coupled with an awareness of the disability and reduced quality of life they convey , they must be recognized as a serious public health problem .',
  'Music performance anxiety ( MPA ) , or stage fright in music performance , is a serious problem for many musicians , because performance impairment accompanied by MPA can threaten their career .',
  'Although the exact diagnostic boundaries for social phobia are difficult to determine , it can be concluded that social anxiety is a distressing problem for a considerable proportion of the general population .',
  'Panic disorder is a serious societal health problem with large consequences , and it affects primarily psychological and role domains .'],
 'postpartum': ['Research indicates some women experiencing depression during pregnancy are dissatisfied with conventional depression treatments due to incomplete effectiveness, dislike of side effects, unsatisfactory experiences with providers and concerns regarding in-utero and breastfeeding safety.',
  'Postnatal depression (PND) is one of the most frequent complications in women of childbearing age in the developed world',
  'Identifying vulnerability to perinatal depression is an important public health issue',
  'Globally, paternal depression is a neglected and under-researched area',
  'Paternal postnatal depression ( PND ) is now recognized as a serious and prevalent problem , associated with poorer well-being and functioning of all family members .',
  'Perinatal maternal depression is a serious health concern with potential lasting negative consequences for children .',
  'Postnatal depression ( PND ) is a serious public health problem in resource-limited countries .',
  'Post-partum fatigue is a serious concern for mothers worldwide .',
  'Postpartum depression is prevalent and concerns a serious health problem for women and their families .',
  "Postpartum depression ( PPD ) is a serious pubic health concern and known to have the adverse effects on mother 's perinatal wellbeing ; and child 's physical and cognitive development .",
  'Postpartum depression is a serious problem not only for mothers , but also for their children and families .',
  'Maternal depression is known to be a serious problem with higher rates among poor and racial/ethnic minority mothers that can have numerous negative impacts on their children .',
  'Maternity Blues , although seldom a serious problem in clinical practice , is potentially important to research on affective disorders in general .',
  'Antenatal depression is a serious problem worldwide that has devastating consequences not only for the mother but also for the child and family .',
  'Postpartum Depression ( PPD ) is a serious public health problem that leads to high maternal morbidity and mortality , enormously affecting the infant , family and society .',
  'The management of severe depression during pregnancy and lactation is a serious concern to both physicians and parents , since the use of tricyclic antidepressant drugs ( TCAs ) has not been proven to be safe .',
  'Antenatal depression is a serious health concern , having the potential to cause wide-reaching adverse consequences for mother and unborn child .',
  'Postpartum mood disorders represent a serious problem affecting 10 - 20 % of women and support groups offer a promising intervention modality .',
  'Postpartum depression : a debilitating yet often unassessed problem .',
  'Postpartum depression is a serious problem for women and their offspring .',
  'Parenting anxiety is a severe problem in mothers of twins not only because it causes mental problems in mothers but also because it has an impact on child mental development .',
  'Postpartum depression ( PPD ) is a serious public health problem affecting 10 % to 15 % of women during the first year after delivery with negative consequences for both mother and infant .',
  'Postnatal depression is a serious mental health problem that may be reduced by exercise .',
  "At postpartum , mothers who were unemployed , had no one to help with childcare , or felt that the baby 's night-time sleep pattern was a serious problem had a higher level of fatigue .",
  'Postpartum depression ( PPD ) is a serious mental health problem .',
  'Postpartum depression ( PPD ) is a serious postpartum mental health problem worldwide .',
  'Postpartum depression ( PPD ) , a severe form of clinical depression , is a serious social problem .'],
 'mothers': ['Research indicates some women experiencing depression during pregnancy are dissatisfied with conventional depression treatments due to incomplete effectiveness, dislike of side effects, unsatisfactory experiences with providers and concerns regarding in-utero and breastfeeding safety.',
  'Postnatal depression (PND) is one of the most frequent complications in women of childbearing age in the developed world',
  'Identifying vulnerability to perinatal depression is an important public health issue',
  'Globally, paternal depression is a neglected and under-researched area',
  'Paternal postnatal depression ( PND ) is now recognized as a serious and prevalent problem , associated with poorer well-being and functioning of all family members .',
  'Perinatal maternal depression is a serious health concern with potential lasting negative consequences for children .',
  'Postnatal depression ( PND ) is a serious public health problem in resource-limited countries .',
  'Post-partum fatigue is a serious concern for mothers worldwide .',
  'Postpartum depression is prevalent and concerns a serious health problem for women and their families .',
  "Postpartum depression ( PPD ) is a serious pubic health concern and known to have the adverse effects on mother 's perinatal wellbeing ; and child 's physical and cognitive development .",
  'Postpartum depression is a serious problem not only for mothers , but also for their children and families .',
  'Maternal depression is known to be a serious problem with higher rates among poor and racial/ethnic minority mothers that can have numerous negative impacts on their children .',
  'Maternity Blues , although seldom a serious problem in clinical practice , is potentially important to research on affective disorders in general .',
  'Antenatal depression is a serious problem worldwide that has devastating consequences not only for the mother but also for the child and family .',
  'Postpartum Depression ( PPD ) is a serious public health problem that leads to high maternal morbidity and mortality , enormously affecting the infant , family and society .',
  'The management of severe depression during pregnancy and lactation is a serious concern to both physicians and parents , since the use of tricyclic antidepressant drugs ( TCAs ) has not been proven to be safe .',
  'Antenatal depression is a serious health concern , having the potential to cause wide-reaching adverse consequences for mother and unborn child .',
  'Postpartum mood disorders represent a serious problem affecting 10 - 20 % of women and support groups offer a promising intervention modality .',
  'Postpartum depression : a debilitating yet often unassessed problem .',
  'Postpartum depression is a serious problem for women and their offspring .',
  'Parenting anxiety is a severe problem in mothers of twins not only because it causes mental problems in mothers but also because it has an impact on child mental development .',
  'Postpartum depression ( PPD ) is a serious public health problem affecting 10 % to 15 % of women during the first year after delivery with negative consequences for both mother and infant .',
  'Postnatal depression is a serious mental health problem that may be reduced by exercise .',
  "At postpartum , mothers who were unemployed , had no one to help with childcare , or felt that the baby 's night-time sleep pattern was a serious problem had a higher level of fatigue .",
  'Postpartum depression ( PPD ) is a serious mental health problem .',
  'Postpartum depression ( PPD ) is a serious postpartum mental health problem worldwide .',
  'Postpartum depression ( PPD ) , a severe form of clinical depression , is a serious social problem .'],
 'postnatal': ['Research indicates some women experiencing depression during pregnancy are dissatisfied with conventional depression treatments due to incomplete effectiveness, dislike of side effects, unsatisfactory experiences with providers and concerns regarding in-utero and breastfeeding safety.',
  'The ability to monitor tissue oxygenation in neonates remains a challenge due to limited blood supply and the reliance on invasive procedures.',
  'Postnatal depression (PND) is one of the most frequent complications in women of childbearing age in the developed world',
  'Identifying vulnerability to perinatal depression is an important public health issue',
  'Globally, paternal depression is a neglected and under-researched area',
  'Paternal postnatal depression ( PND ) is now recognized as a serious and prevalent problem , associated with poorer well-being and functioning of all family members .',
  'Perinatal maternal depression is a serious health concern with potential lasting negative consequences for children .',
  'Postnatal depression ( PND ) is a serious public health problem in resource-limited countries .',
  'Post-partum fatigue is a serious concern for mothers worldwide .',
  'With neonatal respiratory support using a heated humidifier , condensation following decreases in temperature within the unheated part of the inspiratory circuit represents a serious problem , due to the resulting drop in absolute humidity .',
  'Postpartum depression is prevalent and concerns a serious health problem for women and their families .',
  "Postpartum depression ( PPD ) is a serious pubic health concern and known to have the adverse effects on mother 's perinatal wellbeing ; and child 's physical and cognitive development .",
  'Even though artificial surfactant is now available , respiratory distress syndrome still remains a serious problem in neonatology .',
  'Postpartum depression is a serious problem not only for mothers , but also for their children and families .',
  'Maternal depression is known to be a serious problem with higher rates among poor and racial/ethnic minority mothers that can have numerous negative impacts on their children .',
  'Maternity Blues , although seldom a serious problem in clinical practice , is potentially important to research on affective disorders in general .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a serious neonatal problem which has a high mortality rate even with advanced modes of mechanical ventilation .',
  'Because of this , lung immaturity is a serious problem in premature infants .',
  'Antenatal depression is a serious problem worldwide that has devastating consequences not only for the mother but also for the child and family .',
  'Despite advances in neonatal care in the past 50 years , bronchopulmonary dysplasia , with all its adverse short-term and long-term consequences , is still a serious problem in neonatal care .',
  'Neonatal respiratory failure ( RF ) is a serious clinical problem associated with high mortality .',
  'Postpartum Depression ( PPD ) is a serious public health problem that leads to high maternal morbidity and mortality , enormously affecting the infant , family and society .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Although ROP incidence did not increase during this review period , it remains a serious problem in high-risk premature infants in our Newborn Intensive Care Unit .',
  'The management of severe depression during pregnancy and lactation is a serious concern to both physicians and parents , since the use of tricyclic antidepressant drugs ( TCAs ) has not been proven to be safe .',
  'Antenatal depression is a serious health concern , having the potential to cause wide-reaching adverse consequences for mother and unborn child .',
  'Postpartum mood disorders represent a serious problem affecting 10 - 20 % of women and support groups offer a promising intervention modality .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight ( VLBW ) infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Postpartum depression : a debilitating yet often unassessed problem .',
  'Postpartum depression is a serious problem for women and their offspring .',
  'Parenting anxiety is a severe problem in mothers of twins not only because it causes mental problems in mothers but also because it has an impact on child mental development .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Postpartum depression ( PPD ) is a serious public health problem affecting 10 % to 15 % of women during the first year after delivery with negative consequences for both mother and infant .',
  'Postnatal depression is a serious mental health problem that may be reduced by exercise .',
  'Bronchopulmonary dysplasia ( BPD ) is a serious and common problem among very low birth weight infants , despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Ventilator-associated pneumonia is a serious problem which needs to be addressed for a better outcome of the ventilated babies .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a severe clinical problem among neonatal intensive care unit ( NICU ) patients .',
  "At postpartum , mothers who were unemployed , had no one to help with childcare , or felt that the baby 's night-time sleep pattern was a serious problem had a higher level of fatigue .",
  'Postpartum depression ( PPD ) is a serious mental health problem .',
  'Postpartum depression ( PPD ) is a serious postpartum mental health problem worldwide .',
  'Postpartum depression ( PPD ) , a severe form of clinical depression , is a serious social problem .'],
 'neuropathic': ['Neuropathy is a common diabetic complication that can result in significant disability.',
  'Neuropathic pain is an abnormal pain, which is related to the activation of extracellular-regulated kinase (ERK) signaling',
  'Guillain-Barré syndrome (GBS) is a postinfectious immune-mediated peripheral neuropathy',
  'Neuroma is usually accompanied by neuropathic pain , which is usually resistant to most analgesics and presents a serious clinical problem .',
  'Neuropathic pain is a serious clinical problem that needs to be solved urgently .',
  'Neuropathic pain is a severe health problem for which there is a lack of effective therapy .',
  'The insufficient pain relief provided by current pharmacotherapy for chronic neuropathic pain is a serious medical problem .',
  'Neuropathic pain is a severe health problem for which there is a lack of effective therapy .',
  'Neuropathic pain is a serious clinical problem to be solved .',
  'The outcome of peripheral nerve injury is often impaired by neuropathic pain , which is resistant to most analgesics and presents a serious clinical problem .',
  'Neuropathic pain is a severe and disabling health problem , often difficult to treat and characterized by specific somatosensory signs and symptoms .',
  'Neuropathic pain constitutes a serious therapeutic problem .',
  'Neuropathic pain is a debilitating clinical problem and difficult to treat .',
  'Neuropathic pain , resulting from the pathological changes of the somatosensory nervous system , remains a severe public health problem worldwide .',
  'Chronic neuropathic pain constitutes a serious public health problem , but the disease mechanisms are only partially understood .',
  'Neuropathic pain , resulting from nervous system injury or dysfunction , can be a serious medical problem and especially difficult to treat .',
  'Neuropathic pain concurrent with mood disorder from peripheral nerve injury is a serious clinical problem that significantly affects quality of life .',
  'Pain can be a serious problem in patients with Guillain-Barré syndrome ( GBS ) .',
  'Neuropathic pain is a severe problem that is difficult to treat clinically .',
  'Neuropathic pain , resulting from somatosensory nervous system dysfunction , remains a serious public health problem worldwide .',
  'Trigeminal neuralgia ( TN ) is a serious health problem , causing brief , recurrent episodes of stabbing or burning facial pain , which patients describe as feeling like an electric shock .',
  'Peripheral neuropathy ( PN ) is a serious problem affecting more than 22 million people in the United States , according to The Pacific Chapter of the Neuropathy Association .',
  'Treatment of neuropathic pain ( NP ) is a serious medical problem .',
  'Out of 52 patients ( 57.1 % ) with neuropathy , 30 ( 57.7 % ) had a severe problem .',
  'Neuropathic pain is a serious public health problem and has a strong affective-motivational component that makes it difficult to treat .',
  'Injury-induced neuropathic pain remains a serious clinical problem .',
  'Neuropathic pain is a severe clinical problem , often appearing as a co-symptom of many diseases or manifesting as a result of damage to the nervous system .',
  'Postherpetic neuralgia ( PHN ) is a vexing problem occurring in 10 to 20 percent of people with from herpes zoster ( shingles ) .',
  'Sensory polyneuropathy can be a serious problem , but for the majority of clinically important neuropathies there are no available therapies .',
  'In particular , neuropathic pain ( e.g. , postherpetic and trigeminal neuralgia , diabetic neuropathy and spinal cord injury ) is a serious clinical problem that affects a high percentage of the world population .'],
 'neuropathy': ['Neuropathy is a common diabetic complication that can result in significant disability.',
  'Neuropathic pain is an abnormal pain, which is related to the activation of extracellular-regulated kinase (ERK) signaling',
  'Guillain-Barré syndrome (GBS) is a postinfectious immune-mediated peripheral neuropathy',
  'Neuroma is usually accompanied by neuropathic pain , which is usually resistant to most analgesics and presents a serious clinical problem .',
  'Neuropathic pain is a serious clinical problem that needs to be solved urgently .',
  'Neuropathic pain is a severe health problem for which there is a lack of effective therapy .',
  'The insufficient pain relief provided by current pharmacotherapy for chronic neuropathic pain is a serious medical problem .',
  'Neuropathic pain is a severe health problem for which there is a lack of effective therapy .',
  'Neuropathic pain is a serious clinical problem to be solved .',
  'The outcome of peripheral nerve injury is often impaired by neuropathic pain , which is resistant to most analgesics and presents a serious clinical problem .',
  'Neuropathic pain is a severe and disabling health problem , often difficult to treat and characterized by specific somatosensory signs and symptoms .',
  'Neuropathic pain constitutes a serious therapeutic problem .',
  'Neuropathic pain is a debilitating clinical problem and difficult to treat .',
  'Neuropathic pain , resulting from the pathological changes of the somatosensory nervous system , remains a severe public health problem worldwide .',
  'Chronic neuropathic pain constitutes a serious public health problem , but the disease mechanisms are only partially understood .',
  'Neuropathic pain , resulting from nervous system injury or dysfunction , can be a serious medical problem and especially difficult to treat .',
  'Neuropathic pain concurrent with mood disorder from peripheral nerve injury is a serious clinical problem that significantly affects quality of life .',
  'Pain can be a serious problem in patients with Guillain-Barré syndrome ( GBS ) .',
  'Neuropathic pain is a severe problem that is difficult to treat clinically .',
  'Neuropathic pain , resulting from somatosensory nervous system dysfunction , remains a serious public health problem worldwide .',
  'Trigeminal neuralgia ( TN ) is a serious health problem , causing brief , recurrent episodes of stabbing or burning facial pain , which patients describe as feeling like an electric shock .',
  'Peripheral neuropathy ( PN ) is a serious problem affecting more than 22 million people in the United States , according to The Pacific Chapter of the Neuropathy Association .',
  'Treatment of neuropathic pain ( NP ) is a serious medical problem .',
  'Out of 52 patients ( 57.1 % ) with neuropathy , 30 ( 57.7 % ) had a severe problem .',
  'Neuropathic pain is a serious public health problem and has a strong affective-motivational component that makes it difficult to treat .',
  'Injury-induced neuropathic pain remains a serious clinical problem .',
  'Neuropathic pain is a severe clinical problem , often appearing as a co-symptom of many diseases or manifesting as a result of damage to the nervous system .',
  'Postherpetic neuralgia ( PHN ) is a vexing problem occurring in 10 to 20 percent of people with from herpes zoster ( shingles ) .',
  'Sensory polyneuropathy can be a serious problem , but for the majority of clinically important neuropathies there are no available therapies .',
  'In particular , neuropathic pain ( e.g. , postherpetic and trigeminal neuralgia , diabetic neuropathy and spinal cord injury ) is a serious clinical problem that affects a high percentage of the world population .'],
 'uti': ['Resistance of uropathogenic bacteria against the common antibiotics is considerable-especially in the elderly.',
  'Urinary Tract Infection (UTI) is one of the most common bacterial infectious diseases which causes considerable morbidity and costly health problems',
  'Urinary tract infections ( UTIs ) are a serious healthcare dilemma influencing millions of patients every year and represent the second most frequent type of body infection .',
  'Urinary tract infection is a serious problem in diabetic patients , and asymptomatic bacteriuria ( ASB ) in these patients is a risk factor for pyelonephritis and renal dysfunction .',
  'The rising incidence of urinary tract infections ( UTIs ) attributable to Escherichia coli resistant isolates is becoming a serious public health concern .',
  'Urinary tract infections ( UTIs ) are a severe public health problem and are caused by a range of pathogens , but most commonly by Escherichia coli , Klebsiella pneumoniae , Proteus mirabilis , Enterococcus faecalis and Staphylococcus saprophyticus .',
  'Urinary tract infection as a preventable cause of pregnancy complications : opportunities , challenges , and a global call to action .',
  'Urinary tract infections are a severe public health problem .',
  'Urinary tract infections ( UTI ) are a serious health problem producing significant morbidity in a vast number of people each year and mostly affecting the quality of life of young women .',
  'Urinary Tract Infections ( UTI ) represent a serious medical problem with considerably high rate of morbidity .',
  'Escherichia coli ( E. coli ) urinary tract infections ( UTIs ) are becoming a serious problem both for pets and humans ( zoonosis ) due to the close contact and to the increasing resistance to antibiotics .',
  'The higher frequency of multiple antibiotic resistance observed among the isolates , particularly isolates from HIV+Mal+ subjects , poses a serious public health concern as these strains may aggravate the prognosis of both UTI and HIV infection .',
  'This study demonstrated that UTIs are a serious health problem among older women that not only affects both physical and mental health but also has serious social consequences .',
  'The emergence of macrolide- or fluoroquinolone-resistant M.genitalium has become a serious problem in the treatment of male urethritis worldwide , but there is no commercial-based detecting kits accepted by the national insurance in Japan .',
  'As the emergence of multiresistant strains is a serious problem , we assessed the feasibility of nonantibiotic treatment of UTI in patients with NLUTD .',
  'Recently , wide spreading of fluoloquinolone resistant Escherichia coli is a serious problem inthe treatment of urinary tract infection .',
  'The increasing rates of resistance exhibited by uropathogens represent a serious problem .',
  'Urinary tract infection ( UTI ) is a severe problem in humans as well as in many domestic animals like pigs .',
  'Recurrent urinary tract infection ( rUTI ) is a serious clinical problem , yet effective therapeutic options are limited , especially against multidrug-resistant uropathogens .',
  'Recurrent UTI often pose a serious problem for affected women .',
  'Uncomplicated urinary tract infection ( UTI ) caused by uropathogenic Escherichia coli(UPEC ) is a serious problem not only among humans but also in companion animals such as dogs and cats .',
  'Bacterial resistance in UTI in Chinese females is a severe problem , which could be resulted from antimicrobial irrational use .',
  'The levels and patterns of resistance of UTI pathogens must be a serious cause for concern and a clear reason for stricter guidelines and regulations in antimicrobial policy .',
  'Urinary tract infection ( UTI ) is a serious health problem affecting millions of people every year .',
  'Urinary tract infections ( UTI ) are a serious health problem affecting millions of people each year .',
  'Urinary tract infections caused by uropathogenic Escherichia coli presents a serious communal and nosocomial health problem initiated by bacterial adhesion to the bladder cells .',
  'Chronic and recurrent urinary tract infections pose a serious medical problem because there are few effective treatment options .',
  'The rising incidence of urinary tract infections ( UTIs ) attributable to Escherichia coli resistant isolates is becoming a serious public health concern .',
  'Antimicrobial resistance has become a serious concern for the treatment of urinary tract infections .',
  'Escherichia coli is one of the most common pathogens in urinary tract infections ( UTIs ) , and antibiotic resistance in E. coli is becoming a serious problem in treating UTI .',
  'Urinary tract infections ( UTIs ) are a serious health problem affecting millions of people each year .',
  'We conclude that there is a high prevalence of E. faecalis in UTI cases with a 100 % MDR rate indicating a serious problem in treating infections by this organism in Egypt .',
  'Urinary Tract Infection ( UTI ) causes a serious health problem and affects millions of people worldwide .',
  'Multi-drug resistant cervicovaginal Escherichia coli ( CVEC ) infections are a serious health problem .'],
 'urinary': ['Resistance of uropathogenic bacteria against the common antibiotics is considerable-especially in the elderly.',
  'Urinary Tract Infection (UTI) is one of the most common bacterial infectious diseases which causes considerable morbidity and costly health problems',
  "A drawback of free supply may be that , as in 24 % of the present series , women primarily use the pads as a solution to the problem of incontinence , without a doctor 's intervention and before a trial of continence-promoting or curative measures .",
  'Desmopressin plays a major role in the treatment of monosymptomatic enuresis but has the drawback of a high relapse rate after medical treatment .',
  'However , a major drawback of LRPE is the transperitoneal route of access to the extraperitoneal prostate .',
  'Prolonged postoperative incontinence is a major drawback of RRP .',
  'However , a major drawback of LRPE is the transperitoneal route of access to the extraperitoneal organ of the prostate .',
  'Urinary incontinence after prostatectomy or radiation is a devastating problem in men and remains the most feared complication following the treatment of localized prostate cancer .',
  'Stress urinary incontinence ( SUI ) , defined as the involuntary loss of considerable amounts of urine during increased abdominal pressure ( exertion , effort , sneezing , coughing , etc . ) , is a severe problem to the individuals affected and a significant medical , social and economic challenge .',
  'Nocturnal enuresis is a serious health problem affecting a significant portion of the population .',
  'Urinary incontinence , although not life threatening , can be a distressing problem with a profound impact on quality of life .',
  'Urinary tract infections ( UTIs ) are a serious healthcare dilemma influencing millions of patients every year and represent the second most frequent type of body infection .',
  'Nocturia -- waking up during the night due to the urge to urinate and empty the bladder -- is a serious problem for affected patients .',
  "It was seen that urinary incontinence is a serious health problem in the postpartum period , that it disrupts a woman 's daily activities , affects her sex life but that despite this , women do not receive needed medical assistance .",
  'Urinary tract infection is a serious problem in diabetic patients , and asymptomatic bacteriuria ( ASB ) in these patients is a risk factor for pyelonephritis and renal dysfunction .',
  'The rising incidence of urinary tract infections ( UTIs ) attributable to Escherichia coli resistant isolates is becoming a serious public health concern .',
  'Urinary tract infections ( UTIs ) are a severe public health problem and are caused by a range of pathogens , but most commonly by Escherichia coli , Klebsiella pneumoniae , Proteus mirabilis , Enterococcus faecalis and Staphylococcus saprophyticus .',
  'Urinary tract infection as a preventable cause of pregnancy complications : opportunities , challenges , and a global call to action .',
  'Urinary tract infections are a severe public health problem .',
  'Urinary tract infections ( UTI ) are a serious health problem producing significant morbidity in a vast number of people each year and mostly affecting the quality of life of young women .',
  'Urinary Tract Infections ( UTI ) represent a serious medical problem with considerably high rate of morbidity .',
  'Escherichia coli ( E. coli ) urinary tract infections ( UTIs ) are becoming a serious problem both for pets and humans ( zoonosis ) due to the close contact and to the increasing resistance to antibiotics .',
  'Incontinence can be a devastating problem to many individuals .',
  'The higher frequency of multiple antibiotic resistance observed among the isolates , particularly isolates from HIV+Mal+ subjects , poses a serious public health concern as these strains may aggravate the prognosis of both UTI and HIV infection .',
  'This study demonstrated that UTIs are a serious health problem among older women that not only affects both physical and mental health but also has serious social consequences .',
  'The emergence of macrolide- or fluoroquinolone-resistant M.genitalium has become a serious problem in the treatment of male urethritis worldwide , but there is no commercial-based detecting kits accepted by the national insurance in Japan .',
  'Urinary complications resulting from benign prostatic hyperplasia and bladder outlet obstruction continue to be a serious health problem .',
  'Urinary incontinence is a debilitating problem that requires careful evaluation .',
  'The students who had experienced urinary loss rated the problem with a 2.3 average score ( ranging form 0 to 6 ) , with 0 being no problem and 10 being a serious problem .',
  'Nocturnal enuresis after the fifth year of life is a distressing problem .',
  'Accidental urine leakage is a distressing problem that affects around one in three women .',
  'As the emergence of multiresistant strains is a serious problem , we assessed the feasibility of nonantibiotic treatment of UTI in patients with NLUTD .',
  'Preview Involuntary loss of urine is a troublesome , embarrassing problem among women .',
  'Overactive bladder ( OAB ) is a distressing problem that affects many women in the UK .',
  'Urinary incontinence is a debilitating problem that affects over 20 million people in the United States .',
  'Recently , wide spreading of fluoloquinolone resistant Escherichia coli is a serious problem inthe treatment of urinary tract infection .',
  'The increasing rates of resistance exhibited by uropathogens represent a serious problem .',
  'Recurrent stress urinary incontinence is a distressing problem .',
  'However , only 24 % of the stress incontinent and 28 % of the urge incontinent patients found their incontinence to be " quite a problem " or " a serious problem . " Patients leaking urine only " occasionally , " " once a week , " leaking " drops , " and finding the leakage to be " a bit of a problem " had median leakage 0 g during ST and 24hPT .',
  'Urinary tract infection ( UTI ) is a severe problem in humans as well as in many domestic animals like pigs .',
  'Anastomotic strictures ( AS ) are uncommon but a vexing problem after radical prostatectomy .',
  'Sixty-five percent of patients using pads considered urinary leakage to be a problem , but only 1 considered it a serious problem .',
  'Urge urinary incontinence is a debilitating chronic condition that poses challenges for affected women and the clinicians who care for them .',
  'Urinary incontinence is a serious problem for many women .',
  'In contrast to urinary continence , erectile dysfunction is still a serious concern for patients who undergo radical prostatectomy .',
  'Recurrent urinary tract infection ( rUTI ) is a serious clinical problem , yet effective therapeutic options are limited , especially against multidrug-resistant uropathogens .',
  'Recurrent UTI often pose a serious problem for affected women .',
  'While severe urinary dysfunction is rare , sexual impairment remains a serious concern after rectal resection with TME .',
  'Uncomplicated urinary tract infection ( UTI ) caused by uropathogenic Escherichia coli(UPEC ) is a serious problem not only among humans but also in companion animals such as dogs and cats .',
  'Urinary retention is a serious urological problem associated with spinal cord injuries ( SCIs ) and other pelvic disorders .',
  'Urinary incontinence post retropubic " anatomical " radical prostatectomy remains a distressing problem for the patient and the physician rating from 6 to 20 % even in the hands of experienced surgeons from high volume Academic Centers .',
  'Urinary incontinence ( UI ) is a distressing problem for older people .',
  'Bacterial resistance in UTI in Chinese females is a severe problem , which could be resulted from antimicrobial irrational use .',
  'Urinary incontinence is a severe and common health problem .',
  'The levels and patterns of resistance of UTI pathogens must be a serious cause for concern and a clear reason for stricter guidelines and regulations in antimicrobial policy .',
  'Urinary tract infection ( UTI ) is a serious health problem affecting millions of people every year .',
  'Urination impairments in children with neurological disorders are a serious clinical problem .',
  'Urinary incontinence results in substantial morbidity within society and presents a serious public health problem .',
  'Urinary tract infections ( UTI ) are a serious health problem affecting millions of people each year .',
  'Women were more often incontinent than men and experienced it as a serious problem , and more women than men had changed their dietary habits .',
  'Urinary tract infections caused by uropathogenic Escherichia coli presents a serious communal and nosocomial health problem initiated by bacterial adhesion to the bladder cells .',
  'Chronic and recurrent urinary tract infections pose a serious medical problem because there are few effective treatment options .',
  'Urinary incontinence ( UI ) or involuntary leakage of urine is a distressing and serious health problem .',
  'Urinary incontinence is a serious and costly problem that affects many patients , especially the elderly .',
  'For a limited group of people , urinary incontinence is a severe problem .',
  'Stress urinary incontinence ( SUI ) is a serious problem in women who have delivered vaginally , and causes some sexual dysfunction .',
  'Urinary incontinence in children is a distressing problem that often is magnified during puberty , since the children then realize the full significance of the disorder .',
  'The rising incidence of urinary tract infections ( UTIs ) attributable to Escherichia coli resistant isolates is becoming a serious public health concern .',
  'Antimicrobial resistance has become a serious concern for the treatment of urinary tract infections .',
  'Escherichia coli is one of the most common pathogens in urinary tract infections ( UTIs ) , and antibiotic resistance in E. coli is becoming a serious problem in treating UTI .',
  'Incontinence is a distressing , complex health problem which disproportionately affects older people .',
  'Urinary tract infections ( UTIs ) are a serious health problem affecting millions of people each year .',
  'Since the surgical technique does not seem to be the factor responsible for such a serious problem , more accentuated by the fact that this operation is becoming increasingly frequent with the increase in life expectancy , an assessment of 15 patients before and after prostatectomy is presented .',
  'We conclude that there is a high prevalence of E. faecalis in UTI cases with a 100 % MDR rate indicating a serious problem in treating infections by this organism in Egypt .',
  'Bladder hyperactivity is a debilitating problem that affects many individuals .',
  'Urinary incontinence after radical prostatectomy continues to be a distressing problem , even with preservation of the neurovascular bundles and meticulous apical dissection .',
  'Urinary Tract Infection ( UTI ) causes a serious health problem and affects millions of people worldwide .',
  'Multi-drug resistant cervicovaginal Escherichia coli ( CVEC ) infections are a serious health problem .'],
 'utis': ['Resistance of uropathogenic bacteria against the common antibiotics is considerable-especially in the elderly.',
  'Urinary Tract Infection (UTI) is one of the most common bacterial infectious diseases which causes considerable morbidity and costly health problems',
  'Urinary tract infections ( UTIs ) are a serious healthcare dilemma influencing millions of patients every year and represent the second most frequent type of body infection .',
  'Urinary tract infection is a serious problem in diabetic patients , and asymptomatic bacteriuria ( ASB ) in these patients is a risk factor for pyelonephritis and renal dysfunction .',
  'The rising incidence of urinary tract infections ( UTIs ) attributable to Escherichia coli resistant isolates is becoming a serious public health concern .',
  'Urinary tract infections ( UTIs ) are a severe public health problem and are caused by a range of pathogens , but most commonly by Escherichia coli , Klebsiella pneumoniae , Proteus mirabilis , Enterococcus faecalis and Staphylococcus saprophyticus .',
  'Urinary tract infection as a preventable cause of pregnancy complications : opportunities , challenges , and a global call to action .',
  'Urinary tract infections are a severe public health problem .',
  'Urinary tract infections ( UTI ) are a serious health problem producing significant morbidity in a vast number of people each year and mostly affecting the quality of life of young women .',
  'Urinary Tract Infections ( UTI ) represent a serious medical problem with considerably high rate of morbidity .',
  'Escherichia coli ( E. coli ) urinary tract infections ( UTIs ) are becoming a serious problem both for pets and humans ( zoonosis ) due to the close contact and to the increasing resistance to antibiotics .',
  'The higher frequency of multiple antibiotic resistance observed among the isolates , particularly isolates from HIV+Mal+ subjects , poses a serious public health concern as these strains may aggravate the prognosis of both UTI and HIV infection .',
  'This study demonstrated that UTIs are a serious health problem among older women that not only affects both physical and mental health but also has serious social consequences .',
  'The emergence of macrolide- or fluoroquinolone-resistant M.genitalium has become a serious problem in the treatment of male urethritis worldwide , but there is no commercial-based detecting kits accepted by the national insurance in Japan .',
  'As the emergence of multiresistant strains is a serious problem , we assessed the feasibility of nonantibiotic treatment of UTI in patients with NLUTD .',
  'Recently , wide spreading of fluoloquinolone resistant Escherichia coli is a serious problem inthe treatment of urinary tract infection .',
  'The increasing rates of resistance exhibited by uropathogens represent a serious problem .',
  'Urinary tract infection ( UTI ) is a severe problem in humans as well as in many domestic animals like pigs .',
  'Recurrent urinary tract infection ( rUTI ) is a serious clinical problem , yet effective therapeutic options are limited , especially against multidrug-resistant uropathogens .',
  'Recurrent UTI often pose a serious problem for affected women .',
  'Uncomplicated urinary tract infection ( UTI ) caused by uropathogenic Escherichia coli(UPEC ) is a serious problem not only among humans but also in companion animals such as dogs and cats .',
  'Bacterial resistance in UTI in Chinese females is a severe problem , which could be resulted from antimicrobial irrational use .',
  'The levels and patterns of resistance of UTI pathogens must be a serious cause for concern and a clear reason for stricter guidelines and regulations in antimicrobial policy .',
  'Urinary tract infection ( UTI ) is a serious health problem affecting millions of people every year .',
  'Urinary tract infections ( UTI ) are a serious health problem affecting millions of people each year .',
  'Urinary tract infections caused by uropathogenic Escherichia coli presents a serious communal and nosocomial health problem initiated by bacterial adhesion to the bladder cells .',
  'Chronic and recurrent urinary tract infections pose a serious medical problem because there are few effective treatment options .',
  'The rising incidence of urinary tract infections ( UTIs ) attributable to Escherichia coli resistant isolates is becoming a serious public health concern .',
  'Antimicrobial resistance has become a serious concern for the treatment of urinary tract infections .',
  'Escherichia coli is one of the most common pathogens in urinary tract infections ( UTIs ) , and antibiotic resistance in E. coli is becoming a serious problem in treating UTI .',
  'Urinary tract infections ( UTIs ) are a serious health problem affecting millions of people each year .',
  'We conclude that there is a high prevalence of E. faecalis in UTI cases with a 100 % MDR rate indicating a serious problem in treating infections by this organism in Egypt .',
  'Urinary Tract Infection ( UTI ) causes a serious health problem and affects millions of people worldwide .',
  'Multi-drug resistant cervicovaginal Escherichia coli ( CVEC ) infections are a serious health problem .'],
 'coli': ['Resistance of uropathogenic bacteria against the common antibiotics is considerable-especially in the elderly.',
  'Urinary Tract Infection (UTI) is one of the most common bacterial infectious diseases which causes considerable morbidity and costly health problems',
  'Infection with Shiga toxin-producing ( Stx ) Escherichia coli ( STEC ) currently represents a serious public health problem due to its life-threatening complications : hemorrhagic colitis and hemolytic uremic syndrome .',
  'Human illness due to infections with Escherichia coli O157 is a serious health concern .',
  'High prevalence of diarrheagenic E. coli compounded by alarming antimicrobial resistances is a serious public health problem .',
  'Gastrointestinal infections are considered a serious public health problem in view of their high incidence and the increasing antibiotic resistance of the microorganisms involved in their pathogenesis , namely Escherichia coli .',
  'Urinary tract infections ( UTIs ) are a serious healthcare dilemma influencing millions of patients every year and represent the second most frequent type of body infection .',
  'Diarrhea-causing Escherichia coli strains are responsible for numerous cases of gastrointestinal disease and constitute a serious health problem throughout the world .',
  'The pool of antimicrobial resistance determinants in the environment and in the gut flora of cattle is a serious public health concern .',
  'Urinary tract infection is a serious problem in diabetic patients , and asymptomatic bacteriuria ( ASB ) in these patients is a risk factor for pyelonephritis and renal dysfunction .',
  'The rising incidence of urinary tract infections ( UTIs ) attributable to Escherichia coli resistant isolates is becoming a serious public health concern .',
  'Shiga toxin-producing Escherichia coli ( STEC ) food-borne infections are reported worldwide and represent a serious problem for public healthcare .',
  'Urinary tract infections ( UTIs ) are a severe public health problem and are caused by a range of pathogens , but most commonly by Escherichia coli , Klebsiella pneumoniae , Proteus mirabilis , Enterococcus faecalis and Staphylococcus saprophyticus .',
  'Urinary tract infection as a preventable cause of pregnancy complications : opportunities , challenges , and a global call to action .',
  'Urinary tract infections are a severe public health problem .',
  'Urinary tract infections ( UTI ) are a serious health problem producing significant morbidity in a vast number of people each year and mostly affecting the quality of life of young women .',
  'Urinary Tract Infections ( UTI ) represent a serious medical problem with considerably high rate of morbidity .',
  'Escherichia coli ( E. coli ) urinary tract infections ( UTIs ) are becoming a serious problem both for pets and humans ( zoonosis ) due to the close contact and to the increasing resistance to antibiotics .',
  'Human illness due to contamination of food by pathogenic strains of Escherichia coli is a serious public health concern and can cause significant economic losses in the food industry .',
  'The higher frequency of multiple antibiotic resistance observed among the isolates , particularly isolates from HIV+Mal+ subjects , poses a serious public health concern as these strains may aggravate the prognosis of both UTI and HIV infection .',
  'This study demonstrated that UTIs are a serious health problem among older women that not only affects both physical and mental health but also has serious social consequences .',
  'The emergence of macrolide- or fluoroquinolone-resistant M.genitalium has become a serious problem in the treatment of male urethritis worldwide , but there is no commercial-based detecting kits accepted by the national insurance in Japan .',
  'Escherichia coli O157:H7 can cause life-threatening gastrointestinal diseases and has been a severe public health problem worldwide in recent years .',
  'Persistence of E. coli O157 in the environment is a serious public health concern .',
  'It is concluded that aminoglycoside resistance in E. coli from broilers with septicaemia remains a serious problem in Hebei , China .',
  'As the emergence of multiresistant strains is a serious problem , we assessed the feasibility of nonantibiotic treatment of UTI in patients with NLUTD .',
  'Foodborne diseases are a serious and growing problem , and the incidence and prevalence of antimicrobial resistance among foodborne pathogens is reported to have increased .',
  'The emerging of antimicrobial-resistant foodborne bacteria is a serious public health concern worldwide .',
  'Recently , wide spreading of fluoloquinolone resistant Escherichia coli is a serious problem inthe treatment of urinary tract infection .',
  'Escherichia coli O157:H7 is a gastrointestinal pathogen that has become a serious public health concern , as it is associated with outbreaks and severe diseases such as hemolytic-uremic syndrome .',
  'Escherichia coli is considered a serious public health problem .',
  'The increasing rates of resistance exhibited by uropathogens represent a serious problem .',
  'Urinary tract infection ( UTI ) is a severe problem in humans as well as in many domestic animals like pigs .',
  'Recurrent urinary tract infection ( rUTI ) is a serious clinical problem , yet effective therapeutic options are limited , especially against multidrug-resistant uropathogens .',
  'Infections with shiga toxin-producing bacteria , like enterohemorrhagic Escherichia coli and Shigella dysenteriae , represent a serious medical problem .',
  'Recurrent UTI often pose a serious problem for affected women .',
  'Recent foodborne E. coli outbreaks has left a serious concern to public health .',
  'Contamination of the environment with human sewage represents a serious public health concern in which Escherichia coli plays a central role , either directly as a human pathogen or indirectly through its use as an indicator organism .',
  'Uncomplicated urinary tract infection ( UTI ) caused by uropathogenic Escherichia coli(UPEC ) is a serious problem not only among humans but also in companion animals such as dogs and cats .',
  'These results suggest that the His6-EMA1 protein expressed in E. coli could be a reliable immunodiagnostic antigen for ELISA test and that T. equi infection is a serious concern in the State of São Paulo , Brazil .',
  'Colisepticemia caused by bloodstream infection of the extraintestinal pathogenic Escherichia coli ( ExPEC ) has become a serious public health problem .',
  'Escherichia coli strains are responsible for many cases of gastrointestinal disease and represent a serious health problem worldwide .',
  'The transmission of antimicrobial resistance genes from enteric bacteria from the animal reservoir to indigenous bacteria in meat is a serious concern , as it can contribute to human exposure to antimicrobial resistance genes .',
  'Entero aggregative Escherichia coli ( EAEC ) is an emerging enteric pathogen associated with acute and persistent diarrhea and the evolution and spread of acquired extended spectrum betalactamases ( ESBLs ) among these strains has become a serious problem in the management of infectious diseases in developing countries .',
  'Bacterial resistance in UTI in Chinese females is a severe problem , which could be resulted from antimicrobial irrational use .',
  'Food-borne pathogens are a serious human health concern worldwide , and the emergence of antibiotic-resistant food pathogens has further confounded this problem .',
  'The levels and patterns of resistance of UTI pathogens must be a serious cause for concern and a clear reason for stricter guidelines and regulations in antimicrobial policy .',
  'Shiga toxin-producing Escherichia coli ( STEC ) are zoonotic foodborne and waterborne pathogens that are a serious public health concern because they cause outbreaks and the potentially fatal hemolytic uremic syndrome ( HUS ) .',
  'The present findings clearly demonstrate that antibiotic-resistant bacteria in beef and milk pose a serious problem in South Africa .',
  'Urinary tract infection ( UTI ) is a serious health problem affecting millions of people every year .',
  'Human infections with Escherichia coli O157:H7 and Salmonella enterica linked to fresh vegetable consumption have become a serious public health problem inflicting a heavy economic burden .',
  'Urinary tract infections ( UTI ) are a serious health problem affecting millions of people each year .',
  'Infection caused by enterotoxigenic Escherichia coli ( ETEC ) poses a serious health problem to children in developing countries .',
  'Urinary tract infections caused by uropathogenic Escherichia coli presents a serious communal and nosocomial health problem initiated by bacterial adhesion to the bladder cells .',
  'Chronic and recurrent urinary tract infections pose a serious medical problem because there are few effective treatment options .',
  'Infection caused by enterotoxigenic Escherichia coli ( ETEC ) poses a serious health problem among children and adults in developing countries .',
  'Enterohemorrhagic Shiga toxin (Stx)-producing Escherichia coli ( EHEC ) infections are a serious public health problem , and Stx is the main pathogenic agent associated with typical hemolytic-uremic syndrome ( HUS ) .',
  'The rising incidence of urinary tract infections ( UTIs ) attributable to Escherichia coli resistant isolates is becoming a serious public health concern .',
  'Antimicrobial resistance has become a serious concern for the treatment of urinary tract infections .',
  'Multiple antibiotic-resistant extra-intestinal pathogenic Escherichia coli ( ExPEC ) strains represent a serious health care problem both for poultry and humans .',
  'The presence of multidrug-resistant Escherichia coli of fecal origin in seafood is a serious concern .',
  'Escherichia coli is one of the most common pathogens in urinary tract infections ( UTIs ) , and antibiotic resistance in E. coli is becoming a serious problem in treating UTI .',
  'The potential presence of human pathogens in vegetables grown in soils contaminated with E. coli O157:H7 is a serious problem to our national food supply as the pathogen may survive on the leaf surface as they come in contact with contaminated soil during germination .',
  'Infection with Shiga toxin (Stx)-producing Escherichia coli ( STEC ) is a serious public health concern , causing severe diarrhea and hemolytic-uremic syndrome .',
  'Urinary tract infections ( UTIs ) are a serious health problem affecting millions of people each year .',
  'Foodborne illness outbreaks resulting from contamination of Escherichia coli O157:H7 remain a serious concern in food safety .',
  'We conclude that there is a high prevalence of E. faecalis in UTI cases with a 100 % MDR rate indicating a serious problem in treating infections by this organism in Egypt .',
  'Urinary Tract Infection ( UTI ) causes a serious health problem and affects millions of people worldwide .',
  'Multi-drug resistant cervicovaginal Escherichia coli ( CVEC ) infections are a serious health problem .'],
 'endodontic': ['Odontology practice has been severely compromised by the pandemic caused by COVID-19 and Spain is one of the countries with higher incidence.',
  'First bite syndrome (FBS) is an orofacial pain condition characterized by moderate to severe unilateral facial pain associated with the first bite or taste of food',
  'The treatment of dentinal hypersensitivity can be a serious problem in professional dental practice .',
  'Pain experienced before , during , or after endodontic therapy is a serious concern to both patients and endodontists , and the variability of discomfort presents a challenge in terms of diagnostic methods , endodontic therapy , and endodontic knowledge .',
  "Dental anxiety is a serious problem that influences both mental and physical patient 's health .",
  'Anxiety induced by dental treatment can become a serious problem , especially for patients with special needs .',
  'About 71.8 % ( n=130 ) of dentists reported that DH was a severe problem in at least 10 % of their patients and that pain from DH lasted no more than 4 weeks .',
  '[ Oro-dental hygiene - a serious problem ] .',
  'Clinical relevance : Dentine hypersensitivity is a persistent and a troublesome clinical condition which at times is under diagnosed by dental professionals who may struggle to resolve the problem to their patients ’ satisfaction successfully .',
  'The purpose of this prospective study was to assess the incidence of flare-ups ( a severe problem requiring an unscheduled visit and treatment ) among patients who received endodontic treatment by the two authors in their respective practices during a period of one year , and also to examine the correlation with pre-operative and operative variables .',
  'The occurrence of musculoskeletal pain in the upper extremities is a serious concern that affects Lebanese dentists .',
  'It represents a serious problem in dentistry as it progresses rapidly and affects young children .',
  'It has been demonstrated that a loss of teeth is a troublesome problem among age-related pathological phenomena of the oral cavity , which influences the entire body , due to the impairment of mastication .',
  'The study had twin objectives : to assess the incidence of flare-ups ( a severe problem requiring an unscheduled visit and treatment ) among patients who received endodontic treatment in the Department of Conservative Dentistry and Endodontics in Vyas Dental college and hospital , Jodhpur during a period of one year , and also to examine the correlation with pre-operative and operative variables .',
  'For well over a century , there has been cognizance that sensitivity is a serious problem , that it arises when the dentin and cementum are exposed , that fluid movement within the dentinal tubules acts as a provocative stimulus , that tubules can be sealed off ( apparently in most instances ) without damage to the tooth or the dental pulp , and that the problem can also be at least partially resolved by suppressing nerve firing within the pulp .',
  'Chronic pain in the orofacial region has always been a vexing problem for dentists to diagnose and treat effectively .',
  'PD is a serious public dental health care problem with a differentiated distribution in regards to severity , age group , type of infection , co-morbidities and risk factors .',
  'Stress : a serious problem in dentistry .',
  'Facing such a serious problem , the dental profession has the responsibility of proposing effective methods that can be applied to most individuals .'],
 'dental': ['Odontology practice has been severely compromised by the pandemic caused by COVID-19 and Spain is one of the countries with higher incidence.',
  'Dental caries has continued to be the major oral disease in the past, as well as the present scenario',
  'Dental caries and periodontal disease are the most common oral diseases',
  'First bite syndrome (FBS) is an orofacial pain condition characterized by moderate to severe unilateral facial pain associated with the first bite or taste of food',
  'Caries is a serious health problem affecting the Polish population , mostly due to a low level of health awareness , which is reflected in irregular check-ups and a tendency for patients to visit the dentist only when they are already experiencing pain .',
  'IFC is a serious and expensive dental health problem affecting about five per cent of children in Simcoe County .',
  'Although South African studies are limited and most of them relied on self-reports , which could have resulted in a serious overestimation of compliance , even these studies indicate serious shortcomings with regard to infection control practices in oral health care facilities in this country .',
  "The absence of an oral practitioner is a serious problem and can reduce the patient 's chances of cure .",
  'Oral diseases are a serious public health problem , which affects the overall health of a person .',
  'Early childhood caries ( ECC ) is a serious problem that progresses rapidly and often goes untreated .',
  'Since caries represents a serious public health problem in Kosovo , an overall preventive programme for oral health promotion is needed , including the oral health education of mothers .',
  '[ A serious chewing gum problem ] .',
  'The treatment of dentinal hypersensitivity can be a serious problem in professional dental practice .',
  'Early Childhood Caries ( ECC ) is a serious public health problem in developed as well as developing nations , with high prevalence among children around the world .',
  'Dental disease is still a serious health problem universally possibly because dental health awareness and dental service utilization is still very low .',
  'However , caries continues to be a problem for the lower socioeconomic strata , even in affluent countries , and is a serious problem in developing countries .',
  'Pain experienced before , during , or after endodontic therapy is a serious concern to both patients and endodontists , and the variability of discomfort presents a challenge in terms of diagnostic methods , endodontic therapy , and endodontic knowledge .',
  'Streptococcus mutans is a major etiologic agent of dental caries , a prevalent worldwide infectious disease and a serious public health concern .',
  "Dental anxiety is a serious problem that influences both mental and physical patient 's health .",
  'It was concluded that , while changes in feeding methods in recent decades have arguably improved pet health by reducing or preventing diseases associated with nutritional deficiencies and excesses , periodontal disease remains a serious , diet-related problem .',
  'Anxiety induced by dental treatment can become a serious problem , especially for patients with special needs .',
  'About 71.8 % ( n=130 ) of dentists reported that DH was a severe problem in at least 10 % of their patients and that pain from DH lasted no more than 4 weeks .',
  '[ Oro-dental hygiene - a serious problem ] .',
  'Although the prevalence of dental caries is continuing to decline , it still affects a majority of the US population and can be a serious problem for those afflicted .',
  'Although dental decay remains a serious problem in the migrant community , the migrant health centers appear to be making a positive impact on the dental health of the children .',
  'Clinical relevance : Dentine hypersensitivity is a persistent and a troublesome clinical condition which at times is under diagnosed by dental professionals who may struggle to resolve the problem to their patients ’ satisfaction successfully .',
  'With progressive urbanization and changes in diet and eating habits , consumption of refined sugars is rising steeply ( Table II ) and dental caries has become a serious problem particularly in children from high socioeconomic homes .',
  'Dental caries is a serious public health concern .',
  'The purpose of this prospective study was to assess the incidence of flare-ups ( a severe problem requiring an unscheduled visit and treatment ) among patients who received endodontic treatment by the two authors in their respective practices during a period of one year , and also to examine the correlation with pre-operative and operative variables .',
  'Erosion is not a serious problem for dental heath in Chinese preschool children .',
  "Great treatment needs and caries prevalence in permanent first molars in Mashhad schoolchildren show that dental caries is still a serious problem in the children of our society ; therefore , education of parents and teachers is necessary for promoting children 's oral health .",
  'The occurrence of musculoskeletal pain in the upper extremities is a serious concern that affects Lebanese dentists .',
  'According to National Oral Health Survey reports and research , Early Childhood Caries has been identified as a serious public health problem in Sri Lanka .',
  'Dental caries remains a serious problem due to its detrimental effects on individual health and quality of life .',
  'We concluded that although there was considerable neglect of root caries , particularly among blacks , it was not a serious problem among older North Carolinians .',
  'It represents a serious problem in dentistry as it progresses rapidly and affects young children .',
  'Early childhood caries ( ECC ) remains a serious problem in several developing and developed countries .',
  'However , the high percentage of inactive licensed dentists in Mexico points to a serious problem .',
  'It has been demonstrated that a loss of teeth is a troublesome problem among age-related pathological phenomena of the oral cavity , which influences the entire body , due to the impairment of mastication .',
  'Early childhood caries is a preventable disease of multifactorial etiology and is a public health problem affecting majority of the preschool-age children of the country .',
  'Early childhood caries ( ECC ) has become a serious medical problem worldwide in the last decade .',
  'Coronary atherosclerosis and periodontal disease , due to their prevalence , are a serious epidemiological problem .',
  'Periodontal disease is a serious oral health problem that is observed in patients with diabetes mellitus .',
  'Poor oral health was flagged as a severe public health problem .',
  'Although tooth loss is a serious health problem for elderly people , little is known about the genetic basis for susceptibility to it .',
  'Baby bottle tooth decay : a preventable health problem in infants .',
  'Early childhood caries ( ECC ) is a serious public health problem in China .',
  'Early childhood caries ( ECC ) is a serious problem that has remained unexplored in sub-Saharan Africa .',
  'Our results confirmed that malocclusion has become a serious oral health problem in Chinese schoolchildren , highlighting the need for proactive interventions at an early age .',
  'The high rates of preventable dental disease in Aboriginal communities are a serious concern from a social standpoint and in terms of service provision and health care expenditure .',
  'Early childhood caries ( ECC ) represents a serious problem in pediatric dentistry .',
  'Early childhood caries ( ECC ) is a serious public health problem in disadvantaged communities in both developing and industrialized countries in which under-nutrition is common .',
  'These results suggest a serious access problem and one that ultimately produces even worse oral health and expensive major procedures for this population in the future .',
  'Chronic oral malodor is a serious concern for about one-fifth of the North American population , and a field of emerging research interest .',
  'The study had twin objectives : to assess the incidence of flare-ups ( a severe problem requiring an unscheduled visit and treatment ) among patients who received endodontic treatment in the Department of Conservative Dentistry and Endodontics in Vyas Dental college and hospital , Jodhpur during a period of one year , and also to examine the correlation with pre-operative and operative variables .',
  'Although malocclusions represent a serious public health issue , there is insufficient information about this problem in adolescents in Brazil , especially in poorer areas .',
  'At the end of the 19th century dental caries had become a serious health problem in many countries , especially among children and young people .',
  'Inflammatory periodontal diseases represent a serious dental and general medical problem due to the high prevalence among the adult population , the presence of clinical forms leading to the destruction of the dentition and tooth loss , insufficient treatment effectiveness and the frequency of relapse , including in connection with the formation of biofilms .',
  'For well over a century , there has been cognizance that sensitivity is a serious problem , that it arises when the dentin and cementum are exposed , that fluid movement within the dentinal tubules acts as a provocative stimulus , that tubules can be sealed off ( apparently in most instances ) without damage to the tooth or the dental pulp , and that the problem can also be at least partially resolved by suppressing nerve firing within the pulp .',
  'Approximately 70 percent have been found to be in urgent need of dental care , a serious problem because many Allston-Brighton parents can not afford to pay for such care .',
  'Secondary caries continuous to be a serious problem although amalgam has been improved to a large extent .',
  'It was concluded from this study that few teeth had been lost during the 5-year period but that dental caries still appeared to be a serious problem among some very elderly people .',
  'Early childhood caries ( ECC ) was a serious oral health concern with high prevalence and a low treatment rate in China , and few researches have focused on preschool children .',
  'The chronic cumulative nature of caries makes treatment needs a severe problem in adults .',
  'Many GUMs available in Indonesia claim to offer nutritional benefits ; however , the current levels of sugar content in GUMs are a serious concern and are inappropriate for inclusion in the diets of young children .',
  'Caries is a social disease and a serious problem , especially in the childhood .',
  'The current data available on the dmft and DMFT indicate that childhood dental caries is still a serious dental public health problem in the UAE that warrants immediate attention by the government and policy makers .',
  'The lack of reliable and recent information about the oral and dental health conditions of many African countries is a serious object of concern .',
  'Although filling a gap in service provision for poor populations , illegal provision of oral care is a serious public health problem , resulting in situations of low-quality care and risks for patients .',
  'Cambodian preschool children have a severe burden of dental caries and a high proportion of families are impacted by this problem .',
  'Chronic pain in the orofacial region has always been a vexing problem for dentists to diagnose and treat effectively .',
  'Early childhood caries ( ECC ) is a serious problem in China .',
  'Dental caries or tooth decay is a preventable and multifactorial disease that affects billions of people globally and is a particular concern in younger populations .',
  'Early childhood caries ( ECC ) is a serious public health problem in both developing and industrialized countries .',
  'Tongue biting in infants has a variety of aetiological factors and is a distressing problem .',
  'Access to oral health care for people living with HIV/AIDS is a severe problem .',
  'I have always done my best with my teeth , including flossing three times a day , but still have a serious problem with gum recession and have lost a few teeth .',
  'PD is a serious public dental health care problem with a differentiated distribution in regards to severity , age group , type of infection , co-morbidities and risk factors .',
  'Clearly , fluoride has raised the threshold of sugar intake at which caries will progress to cavitation , but fluoride has its limits , and caries remains a serious problem for disadvantaged individuals in many industrialized countries and is a rising problem in many developing countries .',
  'Early childhood caries , a serious health problem among young children , can be prevented with effective intervention .',
  'Access to quality dental care for many adults and children remains a serious concern .',
  'Dental caries is a diet-associated disease which continues to be a serious health problem in most industrialized and developing countries .',
  'The aim of the work was to determine the relationship between the level of HCHO and the levels of its generators in pathologically changed teeth , mainly carietic teeth as tooth caries is still a serious and commonly occurring problem .',
  'Dental caries still constitutes a serious health problem in Łódzkie voivodeship .',
  'Stress : a serious problem in dentistry .',
  'Early childhood caries in preschool children of Kosovo - a serious public health problem .',
  'Dental caries ( decay ) is a serious problem for young Aboriginal children , causing pain and stress .',
  'Facing such a serious problem , the dental profession has the responsibility of proposing effective methods that can be applied to most individuals .',
  'Lack of access to oral care is a severe problem in the United States with over one-third of the population lacking dental insurance .',
  'Childhood dental caries is a serious dental public health problem that warrants the immediate attention of the government and the dental profession officials in Saudi Arabia .',
  'The view that periodontal diseases are a much more prevalent and a severe problem in the developing countries seems to be true only in terms of poorer oral hygiene and considerably greater calculus retention , already at a young age , but not so clear for periodontal destruction in adults .'],
 'fatigue': ['Many cancer patients suffer from symptoms of anxiety, depression, and fatigue.',
  'Approximately 70% of the patients who receive chemotherapy suffer from fatigue, which lowers their quality of life and also has a negative influence on therapeutic efficacy.',
  'Cancer-related fatigue (CRF) is one of the most common and disabling outcomes in patients with breast cancer (BC)',
  'A high prevalence of depression exists among individuals with cancer, which negatively affects their health outcomes, quality of life, and adherence to cancer treatment',
  'Fatigue in patients with sarcoidosis in clinical remission is a frequent symptom and can be characterized as a severe and long-lasting problem , symptomatically similar to CFS .',
  'Fatigue is a distressing and pervasive problem for people with cancer .',
  'Fatigue remains a severe problem in breast cancer patients , especially in younger women .',
  'Fatigue is a serious problem for individuals experiencing chronic illness that can cause difficulties managing self-care activities and achieving quality of life .',
  'Chronic fatigue syndrome ( CFS ) is a serious health concern affecting over 800000 Americans of all ages , races , socioeconomic groups and genders .',
  'Cancer-related fatigue is a serious problem that impairs patients physically , mentally , and socially .',
  'Having a life-threatening or terminal illness directly challenges normal AYA developmental tasks and identity formation .',
  "It is concluded that fatigue does not constitute a serious problem for most patients and that discussion of fatigue with the GP tends to depend on the occurrence of other psychological or physical problems and the patient 's social context .",
  'As fatigue is becoming a serious problem in the modern society affecting human health , work efficiency , and quality of life , effective antifatigue remedies other than pharmacological drugs or therapies are highly needed .',
  'Findings revealed that fatigue is a serious problem for some young adult survivors of childhood cancer and affects many aspects of quality of life .',
  'Women who have been treated for breast cancer may identify vasomotor symptoms , such as hot flushes and night sweats ( HFNS ) , as a serious problem .',
  'Emergence of LRSA is a serious concern for CF patients who undergo prolonged courses of LZD therapy .',
  'Cancer as a life-threatening disease develops a range of existential challenges in persons .',
  'Adolescents and young adults ( AYAs ; 16 - 25 years old ) with cancer may be particularly affected by social interactions , as they can be grappling with a serious illness and normal developmental challenges .',
  "Because cancer is a life-threatening illness , its impact on the patient 's emotional well-being , such as suicidal thoughts , has become a significant problem in public health as well as in clinical oncology .",
  'Cancer-related fatigue ( CRF ) is a serious clinical problem and is one of the most common symptoms experienced by cancer patients .',
  "Fatigue is a severe problem in FSHD and has a huge impact on patients ' lives .",
  'Chronic fatigue syndrome ( CFS ) is a serious health concern affecting over 800000 Americans of all ages , races and socioeconomic groups and both genders .',
  'Sweating can be a distressing and difficult problem to manage in patients with advanced cancer .',
  'In conclusion , for one fifth of a group of disease-free cancer patients fatigue is a severe problem long after treatment .',
  'Fatigue in cancer survivors is a serious problem in pediatric oncology , but reports on this issue are limited , especially in Asian countries .',
  'Healthcare professionals must recognise fatigue as a severe problem for RA patients and start the conversation on fatigue instead of waiting for the patient to mention fatigue spontaneously .',
  'CFS is a serious health-care problem with a prevalence of up to 3 % .',
  'Chronic fatigue syndrome ( CFS ) is a serious health concern affecting over 800,000 Americans of all ages , races , socioeconomic groups and genders .',
  'Fatigue is a severe problem in a large proportion of long-term surviving LGG patients .',
  'Cancer is a serious public health problem worldwide , and its relationship with affective disorders is not clear .',
  'Baseline results indicated that fatigue is a severe problem for 28 % of the investigated patients .',
  'In the balancing of pros and cons according to Wilson and Jungner criteria , the advantages for the CF patient were considered clear , even though CF remains a severe health problem with treatment .',
  'Fatigue is a serious problem for the majority of patients with cancer .',
  'Holistic suffering is a debilitating problem for cancer patients .'],
 'cfs': ['Many cancer patients suffer from symptoms of anxiety, depression, and fatigue.',
  'Approximately 70% of the patients who receive chemotherapy suffer from fatigue, which lowers their quality of life and also has a negative influence on therapeutic efficacy.',
  'Cancer-related fatigue (CRF) is one of the most common and disabling outcomes in patients with breast cancer (BC)',
  'A high prevalence of depression exists among individuals with cancer, which negatively affects their health outcomes, quality of life, and adherence to cancer treatment',
  'Fatigue in patients with sarcoidosis in clinical remission is a frequent symptom and can be characterized as a severe and long-lasting problem , symptomatically similar to CFS .',
  'Fatigue is a distressing and pervasive problem for people with cancer .',
  'Fatigue remains a severe problem in breast cancer patients , especially in younger women .',
  'Fatigue is a serious problem for individuals experiencing chronic illness that can cause difficulties managing self-care activities and achieving quality of life .',
  'Chronic fatigue syndrome ( CFS ) is a serious health concern affecting over 800000 Americans of all ages , races , socioeconomic groups and genders .',
  'Cancer-related fatigue is a serious problem that impairs patients physically , mentally , and socially .',
  'Having a life-threatening or terminal illness directly challenges normal AYA developmental tasks and identity formation .',
  "It is concluded that fatigue does not constitute a serious problem for most patients and that discussion of fatigue with the GP tends to depend on the occurrence of other psychological or physical problems and the patient 's social context .",
  'As fatigue is becoming a serious problem in the modern society affecting human health , work efficiency , and quality of life , effective antifatigue remedies other than pharmacological drugs or therapies are highly needed .',
  'Findings revealed that fatigue is a serious problem for some young adult survivors of childhood cancer and affects many aspects of quality of life .',
  'Women who have been treated for breast cancer may identify vasomotor symptoms , such as hot flushes and night sweats ( HFNS ) , as a serious problem .',
  'Emergence of LRSA is a serious concern for CF patients who undergo prolonged courses of LZD therapy .',
  'Cancer as a life-threatening disease develops a range of existential challenges in persons .',
  'Adolescents and young adults ( AYAs ; 16 - 25 years old ) with cancer may be particularly affected by social interactions , as they can be grappling with a serious illness and normal developmental challenges .',
  "Because cancer is a life-threatening illness , its impact on the patient 's emotional well-being , such as suicidal thoughts , has become a significant problem in public health as well as in clinical oncology .",
  'Cancer-related fatigue ( CRF ) is a serious clinical problem and is one of the most common symptoms experienced by cancer patients .',
  "Fatigue is a severe problem in FSHD and has a huge impact on patients ' lives .",
  'Chronic fatigue syndrome ( CFS ) is a serious health concern affecting over 800000 Americans of all ages , races and socioeconomic groups and both genders .',
  'Sweating can be a distressing and difficult problem to manage in patients with advanced cancer .',
  'In conclusion , for one fifth of a group of disease-free cancer patients fatigue is a severe problem long after treatment .',
  'Fatigue in cancer survivors is a serious problem in pediatric oncology , but reports on this issue are limited , especially in Asian countries .',
  'Healthcare professionals must recognise fatigue as a severe problem for RA patients and start the conversation on fatigue instead of waiting for the patient to mention fatigue spontaneously .',
  'CFS is a serious health-care problem with a prevalence of up to 3 % .',
  'Chronic fatigue syndrome ( CFS ) is a serious health concern affecting over 800,000 Americans of all ages , races , socioeconomic groups and genders .',
  'Fatigue is a severe problem in a large proportion of long-term surviving LGG patients .',
  'Cancer is a serious public health problem worldwide , and its relationship with affective disorders is not clear .',
  'Baseline results indicated that fatigue is a severe problem for 28 % of the investigated patients .',
  'In the balancing of pros and cons according to Wilson and Jungner criteria , the advantages for the CF patient were considered clear , even though CF remains a severe health problem with treatment .',
  'Fatigue is a serious problem for the majority of patients with cancer .',
  'Holistic suffering is a debilitating problem for cancer patients .'],
 'incontinence': ['The train toilet can form a barrier for those wishing to travel by train as it is perceived as being dirty, and therefore its use as being unpleasant.',
  "A drawback of free supply may be that , as in 24 % of the present series , women primarily use the pads as a solution to the problem of incontinence , without a doctor 's intervention and before a trial of continence-promoting or curative measures .",
  'Desmopressin plays a major role in the treatment of monosymptomatic enuresis but has the drawback of a high relapse rate after medical treatment .',
  'However , a major drawback of LRPE is the transperitoneal route of access to the extraperitoneal prostate .',
  'Prolonged postoperative incontinence is a major drawback of RRP .',
  'However , a major drawback of LRPE is the transperitoneal route of access to the extraperitoneal organ of the prostate .',
  'Urinary incontinence after prostatectomy or radiation is a devastating problem in men and remains the most feared complication following the treatment of localized prostate cancer .',
  'Stress urinary incontinence ( SUI ) , defined as the involuntary loss of considerable amounts of urine during increased abdominal pressure ( exertion , effort , sneezing , coughing , etc . ) , is a severe problem to the individuals affected and a significant medical , social and economic challenge .',
  'Nocturnal enuresis is a serious health problem affecting a significant portion of the population .',
  'Treatment of anal incontinence in children with a pathology of the distal portion of the spine is a serious problem .',
  'Urinary incontinence , although not life threatening , can be a distressing problem with a profound impact on quality of life .',
  'Fecal incontinence represents a devastating problem that often prevents a patient from becoming socially accepted and may cause serious psychological sequelae .',
  'Nocturia -- waking up during the night due to the urge to urinate and empty the bladder -- is a serious problem for affected patients .',
  'Anal incontinence is a devastating affliction with several considerations that make it difficult to define in terms of epidemiology with good precision .',
  "Fecal incontinence is a debilitating and common problem with a profound effect on a patient 's well being medically , socially , and economically .",
  'Fecal incontinence is a serious problem that may lead to social segregation and psychological problems .',
  "It was seen that urinary incontinence is a serious health problem in the postpartum period , that it disrupts a woman 's daily activities , affects her sex life but that despite this , women do not receive needed medical assistance .",
  'Fecal incontinence is a debilitating and highly prevalent problem among multiple sclerosis patients .',
  'Faecal incontinence is a distressing and socially debilitating problem .',
  'Incontinence can be a devastating problem to many individuals .',
  'Urinary complications resulting from benign prostatic hyperplasia and bladder outlet obstruction continue to be a serious health problem .',
  'Fecal incontinence is a debilitating problem for many children , especially those with anorectal malformations .',
  'Fecal incontinence is a debilitating problem facing ~2.2 % of the U.S. general population over 65 years of age .',
  'Urinary incontinence is a debilitating problem that requires careful evaluation .',
  'The students who had experienced urinary loss rated the problem with a 2.3 average score ( ranging form 0 to 6 ) , with 0 being no problem and 10 being a serious problem .',
  'Nocturnal enuresis after the fifth year of life is a distressing problem .',
  'Accidental urine leakage is a distressing problem that affects around one in three women .',
  'Faecal incontinence is a debilitating problem with significant medical , social and economic implications .',
  'Preview Involuntary loss of urine is a troublesome , embarrassing problem among women .',
  'Faecal incontinence is a distressing and embarrassing problem that can have a profound affect upon quality of life .',
  'Overactive bladder ( OAB ) is a distressing problem that affects many women in the UK .',
  'Urinary incontinence is a debilitating problem that affects over 20 million people in the United States .',
  'Fecal incontinence is a devastating disability , and although this condition is widely accepted as a problem in the elderly , it is now becoming apparent that much younger age groups are also frequently affected .',
  'Recurrent stress urinary incontinence is a distressing problem .',
  'However , only 24 % of the stress incontinent and 28 % of the urge incontinent patients found their incontinence to be " quite a problem " or " a serious problem . " Patients leaking urine only " occasionally , " " once a week , " leaking " drops , " and finding the leakage to be " a bit of a problem " had median leakage 0 g during ST and 24hPT .',
  'Anastomotic strictures ( AS ) are uncommon but a vexing problem after radical prostatectomy .',
  'Faecal incontinence is a debilitating problem with significant medical , social and economic implications .',
  'Faecal incontinence is a debilitating problem with significant medical , social and economic implications .',
  'Sixty-five percent of patients using pads considered urinary leakage to be a problem , but only 1 considered it a serious problem .',
  'Urge urinary incontinence is a debilitating chronic condition that poses challenges for affected women and the clinicians who care for them .',
  'Urinary incontinence is a serious problem for many women .',
  'In contrast to urinary continence , erectile dysfunction is still a serious concern for patients who undergo radical prostatectomy .',
  'Fecal incontinence is a serious problem especially for the elderly .',
  'While severe urinary dysfunction is rare , sexual impairment remains a serious concern after rectal resection with TME .',
  'Urinary retention is a serious urological problem associated with spinal cord injuries ( SCIs ) and other pelvic disorders .',
  'Urinary incontinence post retropubic " anatomical " radical prostatectomy remains a distressing problem for the patient and the physician rating from 6 to 20 % even in the hands of experienced surgeons from high volume Academic Centers .',
  'Fecal incontinence is a debilitating problem that has many different causes .',
  'Chronic diarrhea with fecal incontinence ( FI ) is a severe , underreported , and intractable problem in many patients for which limited pharmaceutical options exist .',
  'Anorectal incontinence is a symptom of a complex multifactorial disorder involving the pelvic floor and anorectum , which is a severe disability and a major social problem .',
  'However , continence is not perfect , and fecal soilage is a troublesome problem for a small number of patients .',
  'Urinary incontinence ( UI ) is a distressing problem for older people .',
  'Overall , 32 % ( 43/135 ) report difficulty with fecal soiling , and 12.6 % ( 17/135 ) identify this as a severe problem .',
  'Urinary incontinence is a severe and common health problem .',
  'Fecal incontinence is a serious psychological and social problem for the patient , frequently leading to social isolation , loss of working potential and depression .',
  'Fecal incontinence is a devastating underestimated problem , affecting a large number of individuals all over the world .',
  'Urination impairments in children with neurological disorders are a serious clinical problem .',
  'Urinary incontinence results in substantial morbidity within society and presents a serious public health problem .',
  'Women were more often incontinent than men and experienced it as a serious problem , and more women than men had changed their dietary habits .',
  'Fecal incontinence is a devastating problem for those afflicted .',
  'Urinary incontinence ( UI ) or involuntary leakage of urine is a distressing and serious health problem .',
  'Faecal incontinence is a distressing problem that is often not amenable to surgical correction .',
  'Urinary incontinence is a serious and costly problem that affects many patients , especially the elderly .',
  'For a limited group of people , urinary incontinence is a severe problem .',
  'Fecal incontinence is a severe problem that affects more than one third of women with spinal cord injury and is associated with decreased quality of life .',
  'Fecal incontinence ( FI ) is a devastating problem for children .',
  'Stress urinary incontinence ( SUI ) is a serious problem in women who have delivered vaginally , and causes some sexual dysfunction .',
  'Urinary incontinence in children is a distressing problem that often is magnified during puberty , since the children then realize the full significance of the disorder .',
  'Fecal incontinence is a serious problem that may lead to social segregation and psychological problems .',
  'Incontinence is a distressing , complex health problem which disproportionately affects older people .',
  'Faecal incontinence is a debilitating problem with significant medical , social and economic implications .',
  'Since the surgical technique does not seem to be the factor responsible for such a serious problem , more accentuated by the fact that this operation is becoming increasingly frequent with the increase in life expectancy , an assessment of 15 patients before and after prostatectomy is presented .',
  'Faecal incontinence is a devastating social and hygiene problem , impacting heavily on quality of life and ability to work and socialise .',
  'Bladder hyperactivity is a debilitating problem that affects many individuals .',
  'Urinary incontinence after radical prostatectomy continues to be a distressing problem , even with preservation of the neurovascular bundles and meticulous apical dissection .'],
 'fecal': ['The train toilet can form a barrier for those wishing to travel by train as it is perceived as being dirty, and therefore its use as being unpleasant.',
  'Treatment of anal incontinence in children with a pathology of the distal portion of the spine is a serious problem .',
  'Fecal incontinence represents a devastating problem that often prevents a patient from becoming socially accepted and may cause serious psychological sequelae .',
  'Anal incontinence is a devastating affliction with several considerations that make it difficult to define in terms of epidemiology with good precision .',
  "Fecal incontinence is a debilitating and common problem with a profound effect on a patient 's well being medically , socially , and economically .",
  'Fecal incontinence is a serious problem that may lead to social segregation and psychological problems .',
  'Fecal incontinence is a debilitating and highly prevalent problem among multiple sclerosis patients .',
  'Faecal incontinence is a distressing and socially debilitating problem .',
  'Fecal incontinence is a debilitating problem for many children , especially those with anorectal malformations .',
  'Fecal incontinence is a debilitating problem facing ~2.2 % of the U.S. general population over 65 years of age .',
  'Faecal incontinence is a debilitating problem with significant medical , social and economic implications .',
  'Faecal incontinence is a distressing and embarrassing problem that can have a profound affect upon quality of life .',
  'Fecal incontinence is a devastating disability , and although this condition is widely accepted as a problem in the elderly , it is now becoming apparent that much younger age groups are also frequently affected .',
  'Faecal incontinence is a debilitating problem with significant medical , social and economic implications .',
  'Faecal incontinence is a debilitating problem with significant medical , social and economic implications .',
  'Fecal incontinence is a serious problem especially for the elderly .',
  'Fecal incontinence is a debilitating problem that has many different causes .',
  'Chronic diarrhea with fecal incontinence ( FI ) is a severe , underreported , and intractable problem in many patients for which limited pharmaceutical options exist .',
  'Anorectal incontinence is a symptom of a complex multifactorial disorder involving the pelvic floor and anorectum , which is a severe disability and a major social problem .',
  'However , continence is not perfect , and fecal soilage is a troublesome problem for a small number of patients .',
  'Overall , 32 % ( 43/135 ) report difficulty with fecal soiling , and 12.6 % ( 17/135 ) identify this as a severe problem .',
  'Fecal incontinence is a serious psychological and social problem for the patient , frequently leading to social isolation , loss of working potential and depression .',
  'Fecal incontinence is a devastating underestimated problem , affecting a large number of individuals all over the world .',
  'Fecal incontinence is a devastating problem for those afflicted .',
  'Faecal incontinence is a distressing problem that is often not amenable to surgical correction .',
  'Fecal incontinence is a severe problem that affects more than one third of women with spinal cord injury and is associated with decreased quality of life .',
  'Fecal incontinence ( FI ) is a devastating problem for children .',
  'Fecal incontinence is a serious problem that may lead to social segregation and psychological problems .',
  'Faecal incontinence is a debilitating problem with significant medical , social and economic implications .',
  'Faecal incontinence is a devastating social and hygiene problem , impacting heavily on quality of life and ability to work and socialise .'],
 'faecal': ['The train toilet can form a barrier for those wishing to travel by train as it is perceived as being dirty, and therefore its use as being unpleasant.',
  'Treatment of anal incontinence in children with a pathology of the distal portion of the spine is a serious problem .',
  'Fecal incontinence represents a devastating problem that often prevents a patient from becoming socially accepted and may cause serious psychological sequelae .',
  'Anal incontinence is a devastating affliction with several considerations that make it difficult to define in terms of epidemiology with good precision .',
  "Fecal incontinence is a debilitating and common problem with a profound effect on a patient 's well being medically , socially , and economically .",
  'Fecal incontinence is a serious problem that may lead to social segregation and psychological problems .',
  'Fecal incontinence is a debilitating and highly prevalent problem among multiple sclerosis patients .',
  'Faecal incontinence is a distressing and socially debilitating problem .',
  'Fecal incontinence is a debilitating problem for many children , especially those with anorectal malformations .',
  'Fecal incontinence is a debilitating problem facing ~2.2 % of the U.S. general population over 65 years of age .',
  'Faecal incontinence is a debilitating problem with significant medical , social and economic implications .',
  'Faecal incontinence is a distressing and embarrassing problem that can have a profound affect upon quality of life .',
  'Fecal incontinence is a devastating disability , and although this condition is widely accepted as a problem in the elderly , it is now becoming apparent that much younger age groups are also frequently affected .',
  'Faecal incontinence is a debilitating problem with significant medical , social and economic implications .',
  'Faecal incontinence is a debilitating problem with significant medical , social and economic implications .',
  'Fecal incontinence is a serious problem especially for the elderly .',
  'Fecal incontinence is a debilitating problem that has many different causes .',
  'Chronic diarrhea with fecal incontinence ( FI ) is a severe , underreported , and intractable problem in many patients for which limited pharmaceutical options exist .',
  'Anorectal incontinence is a symptom of a complex multifactorial disorder involving the pelvic floor and anorectum , which is a severe disability and a major social problem .',
  'However , continence is not perfect , and fecal soilage is a troublesome problem for a small number of patients .',
  'Overall , 32 % ( 43/135 ) report difficulty with fecal soiling , and 12.6 % ( 17/135 ) identify this as a severe problem .',
  'Fecal incontinence is a serious psychological and social problem for the patient , frequently leading to social isolation , loss of working potential and depression .',
  'Fecal incontinence is a devastating underestimated problem , affecting a large number of individuals all over the world .',
  'Fecal incontinence is a devastating problem for those afflicted .',
  'Faecal incontinence is a distressing problem that is often not amenable to surgical correction .',
  'Fecal incontinence is a severe problem that affects more than one third of women with spinal cord injury and is associated with decreased quality of life .',
  'Fecal incontinence ( FI ) is a devastating problem for children .',
  'Fecal incontinence is a serious problem that may lead to social segregation and psychological problems .',
  'Faecal incontinence is a debilitating problem with significant medical , social and economic implications .',
  'Faecal incontinence is a devastating social and hygiene problem , impacting heavily on quality of life and ability to work and socialise .'],
 'cytomegalovirus': ['Infection with CMV remains a major cause of morbidity and mortality after allogeneic stem cell transplantation (aSCT).',
  'Human cytomegalovirus ( HCMV ) resistance to antiviral drugs is a major drawback of repeated or long-duration treatment in immunocompromised patients .',
  'Human cytomegalovirus ( HCMV ) is the major viral cause of birth defects and a serious problem in immunocompromised individuals and has been associated with atherosclerosis .',
  'The antiviral resistance of cytomegalovirus ( CMV ) infections is associated with mutations in the CMV UL54 and UL97 gene regions and is a serious problem in immunocompromised patients .',
  'The development of infections with ganciclovir (GCV)-resistant human cytomegalovirus ( HCMV ) remains a serious problem in recipients of stem cell or organ transplants .',
  'Congenital cytomegalovirus ( CMV ) infection is a serious health problem .',
  'Our findings provide one possible explanation for the tumorigenicity of KSHV , which poses a severe problem in immunocompromised patients .',
  'Cytomegalovirus ( CMV ) infection remains a serious problem after lung transplantation .',
  'However , late-onset CMV disease is now emerging as a serious problem .',
  'Reactivation of human cytomegalovirus ( HCMV ) remains a serious problem in immunosuppressed individuals .',
  'Although human cytomegalovirus ( HCMV ) rarely causes overt disease in healthy individuals , the virus can be a serious , even life-threatening problem in immunosuppressed or immune-deficient patients and in the setting of maternofetal primary infection .',
  'Human cytomegalovirus ( HCMV ) infections are a major cause of mortality and morbidity in human transplant recipients and a serious problem in patients with AIDS .',
  'HZ is a debilitating illness , and while mortality is low , morbidity remains a significant cause for concern with prevention efforts aimed at reducing VZV reactivation and its complications .',
  'While resistance is not a serious issue for immunocompetent individuals , it is a real concern for immunocompromised patients , especially those with AIDS and the ones that have undergone organ transplantation .',
  'Cytomegalovirus infection is a serious problem in immunocompromised patients particularly in acquired immunodeficiency syndrome .',
  'In transplant recipients , drug-resistant human cytomegalovirus ( HCMV ) infections remain a serious problem .',
  'Infection of immunocompromised patients with cytomegalovirus ( CMV ) , such as that occurring in patients undergoing hematopoietic stem cell transplantation , is a serious clinical problem .',
  'Human cytomegalovirus ( HCMV ) poses a serious public health problem causing morbidity and mortality in transplant recipients , immunocompromised patients , and congenitally infected newborns .',
  'While resistance is not a serious issue for immunocompetent individuals , it is a real concern for immunocompromised patients , especially those with AIDS and the ones that have undergone organ transplantation .',
  'Human cytomegalovirus ( HCMV ) is the major viral cause of birth defects and a serious problem for immunocompromised individuals .',
  'Cytomegalovirus ( CMV ) infection remains a serious problem in lung transplant recipients .',
  'Ad infections are a serious problem for solid-organ transplant recipients and AIDS patients as well .',
  'Cytomegalovirus ( CMV ) infection remains a serious problem after heart transplantation .',
  'Polyomavirus BK ( BKV ) is a serious problem for immunocompromised patients , where latent virus can enter into the lytic cycle causing cytolytic destruction of host cells .',
  'In contrast , cytomegalovirus has become of increased importance in view of the large number of patients immunosuppressed for transplantation and cancer therapy ; bacterial growth in blood components appears to be increasingly common ; and Chagas disease is likely to become a serious transfusion problem in this country .',
  'Primary or recurrent viral infections , especially by herpetoviridae , with viraemias -- after organ transplants , for example -- are a serious medical problem which can affect the prognosis for survival .',
  'Infection with human cytomegalovirus ( HCMV ) is a serious medical problem , particularly in immunocompromised individuals and neonates .',
  'For immunocompromised hosts , human cytomegalovirus ( CMV ) can be a serious problem .',
  'While resistance is not a serious issue for immunocompetent individuals , it is a real concern for immunocompromised patients , especially those with AIDS and the ones that have undergone organ transplantation .',
  'We consider VZV reactivation a serious concern in the autologous transplant setting , requiring extended prophylaxis .',
  'Infection with human cytomegalovirus ( HCMV ) is a serious medical problem , particularly in immunocompromised individuals and neonates .',
  'Notably , HCMV infection is a serious , sometimes life-threatening medical problem for newborns and immunosuppressed individuals , including transplant recipients and patients under antitumoral chemotherapy .',
  'Cytomegalovirus retinitis remains a serious problem in AIDS patients , and the species specificity of human cytomegalovirus ( HCMV ) has hindered the development of animal models suitable for testing new therapeutic agents .',
  'Polyomavirus BK-associated nephropathy ( BKVN ) has been a serious problem after kidney transplantation .',
  'Resistance to antiviral drugs can be a severe problem in transplant recipients .',
  'Viral infections are still a serious diagnostic and therapeutic problem in patients undergoing alternative donor transplants .',
  'In recent years , BK virus ( BKV ) nephritis after renal transplantation has become a severe problem .'],
 'hcmv': ['Infection with CMV remains a major cause of morbidity and mortality after allogeneic stem cell transplantation (aSCT).',
  'Human cytomegalovirus ( HCMV ) resistance to antiviral drugs is a major drawback of repeated or long-duration treatment in immunocompromised patients .',
  'Human cytomegalovirus ( HCMV ) is the major viral cause of birth defects and a serious problem in immunocompromised individuals and has been associated with atherosclerosis .',
  'The antiviral resistance of cytomegalovirus ( CMV ) infections is associated with mutations in the CMV UL54 and UL97 gene regions and is a serious problem in immunocompromised patients .',
  'The development of infections with ganciclovir (GCV)-resistant human cytomegalovirus ( HCMV ) remains a serious problem in recipients of stem cell or organ transplants .',
  'Congenital cytomegalovirus ( CMV ) infection is a serious health problem .',
  'Our findings provide one possible explanation for the tumorigenicity of KSHV , which poses a severe problem in immunocompromised patients .',
  'Cytomegalovirus ( CMV ) infection remains a serious problem after lung transplantation .',
  'However , late-onset CMV disease is now emerging as a serious problem .',
  'Reactivation of human cytomegalovirus ( HCMV ) remains a serious problem in immunosuppressed individuals .',
  'Although human cytomegalovirus ( HCMV ) rarely causes overt disease in healthy individuals , the virus can be a serious , even life-threatening problem in immunosuppressed or immune-deficient patients and in the setting of maternofetal primary infection .',
  'Human cytomegalovirus ( HCMV ) infections are a major cause of mortality and morbidity in human transplant recipients and a serious problem in patients with AIDS .',
  'HZ is a debilitating illness , and while mortality is low , morbidity remains a significant cause for concern with prevention efforts aimed at reducing VZV reactivation and its complications .',
  'While resistance is not a serious issue for immunocompetent individuals , it is a real concern for immunocompromised patients , especially those with AIDS and the ones that have undergone organ transplantation .',
  'Cytomegalovirus infection is a serious problem in immunocompromised patients particularly in acquired immunodeficiency syndrome .',
  'In transplant recipients , drug-resistant human cytomegalovirus ( HCMV ) infections remain a serious problem .',
  'Infection of immunocompromised patients with cytomegalovirus ( CMV ) , such as that occurring in patients undergoing hematopoietic stem cell transplantation , is a serious clinical problem .',
  'Human cytomegalovirus ( HCMV ) poses a serious public health problem causing morbidity and mortality in transplant recipients , immunocompromised patients , and congenitally infected newborns .',
  'While resistance is not a serious issue for immunocompetent individuals , it is a real concern for immunocompromised patients , especially those with AIDS and the ones that have undergone organ transplantation .',
  'Human cytomegalovirus ( HCMV ) is the major viral cause of birth defects and a serious problem for immunocompromised individuals .',
  'Cytomegalovirus ( CMV ) infection remains a serious problem in lung transplant recipients .',
  'Ad infections are a serious problem for solid-organ transplant recipients and AIDS patients as well .',
  'Cytomegalovirus ( CMV ) infection remains a serious problem after heart transplantation .',
  'Polyomavirus BK ( BKV ) is a serious problem for immunocompromised patients , where latent virus can enter into the lytic cycle causing cytolytic destruction of host cells .',
  'In contrast , cytomegalovirus has become of increased importance in view of the large number of patients immunosuppressed for transplantation and cancer therapy ; bacterial growth in blood components appears to be increasingly common ; and Chagas disease is likely to become a serious transfusion problem in this country .',
  'Primary or recurrent viral infections , especially by herpetoviridae , with viraemias -- after organ transplants , for example -- are a serious medical problem which can affect the prognosis for survival .',
  'Infection with human cytomegalovirus ( HCMV ) is a serious medical problem , particularly in immunocompromised individuals and neonates .',
  'For immunocompromised hosts , human cytomegalovirus ( CMV ) can be a serious problem .',
  'While resistance is not a serious issue for immunocompetent individuals , it is a real concern for immunocompromised patients , especially those with AIDS and the ones that have undergone organ transplantation .',
  'We consider VZV reactivation a serious concern in the autologous transplant setting , requiring extended prophylaxis .',
  'Infection with human cytomegalovirus ( HCMV ) is a serious medical problem , particularly in immunocompromised individuals and neonates .',
  'Notably , HCMV infection is a serious , sometimes life-threatening medical problem for newborns and immunosuppressed individuals , including transplant recipients and patients under antitumoral chemotherapy .',
  'Cytomegalovirus retinitis remains a serious problem in AIDS patients , and the species specificity of human cytomegalovirus ( HCMV ) has hindered the development of animal models suitable for testing new therapeutic agents .',
  'Polyomavirus BK-associated nephropathy ( BKVN ) has been a serious problem after kidney transplantation .',
  'Resistance to antiviral drugs can be a severe problem in transplant recipients .',
  'Viral infections are still a serious diagnostic and therapeutic problem in patients undergoing alternative donor transplants .',
  'In recent years , BK virus ( BKV ) nephritis after renal transplantation has become a severe problem .'],
 'immunocompromised': ['Infection with CMV remains a major cause of morbidity and mortality after allogeneic stem cell transplantation (aSCT).',
  'Human cytomegalovirus ( HCMV ) resistance to antiviral drugs is a major drawback of repeated or long-duration treatment in immunocompromised patients .',
  'Human cytomegalovirus ( HCMV ) is the major viral cause of birth defects and a serious problem in immunocompromised individuals and has been associated with atherosclerosis .',
  'The antiviral resistance of cytomegalovirus ( CMV ) infections is associated with mutations in the CMV UL54 and UL97 gene regions and is a serious problem in immunocompromised patients .',
  'The development of infections with ganciclovir (GCV)-resistant human cytomegalovirus ( HCMV ) remains a serious problem in recipients of stem cell or organ transplants .',
  'Congenital cytomegalovirus ( CMV ) infection is a serious health problem .',
  'Our findings provide one possible explanation for the tumorigenicity of KSHV , which poses a severe problem in immunocompromised patients .',
  'Cytomegalovirus ( CMV ) infection remains a serious problem after lung transplantation .',
  'However , late-onset CMV disease is now emerging as a serious problem .',
  'Reactivation of human cytomegalovirus ( HCMV ) remains a serious problem in immunosuppressed individuals .',
  'Although human cytomegalovirus ( HCMV ) rarely causes overt disease in healthy individuals , the virus can be a serious , even life-threatening problem in immunosuppressed or immune-deficient patients and in the setting of maternofetal primary infection .',
  'Human cytomegalovirus ( HCMV ) infections are a major cause of mortality and morbidity in human transplant recipients and a serious problem in patients with AIDS .',
  'HZ is a debilitating illness , and while mortality is low , morbidity remains a significant cause for concern with prevention efforts aimed at reducing VZV reactivation and its complications .',
  'While resistance is not a serious issue for immunocompetent individuals , it is a real concern for immunocompromised patients , especially those with AIDS and the ones that have undergone organ transplantation .',
  'Cytomegalovirus infection is a serious problem in immunocompromised patients particularly in acquired immunodeficiency syndrome .',
  'In transplant recipients , drug-resistant human cytomegalovirus ( HCMV ) infections remain a serious problem .',
  'Infection of immunocompromised patients with cytomegalovirus ( CMV ) , such as that occurring in patients undergoing hematopoietic stem cell transplantation , is a serious clinical problem .',
  'Human cytomegalovirus ( HCMV ) poses a serious public health problem causing morbidity and mortality in transplant recipients , immunocompromised patients , and congenitally infected newborns .',
  'While resistance is not a serious issue for immunocompetent individuals , it is a real concern for immunocompromised patients , especially those with AIDS and the ones that have undergone organ transplantation .',
  'Human cytomegalovirus ( HCMV ) is the major viral cause of birth defects and a serious problem for immunocompromised individuals .',
  'Cytomegalovirus ( CMV ) infection remains a serious problem in lung transplant recipients .',
  'Ad infections are a serious problem for solid-organ transplant recipients and AIDS patients as well .',
  'Cytomegalovirus ( CMV ) infection remains a serious problem after heart transplantation .',
  'Polyomavirus BK ( BKV ) is a serious problem for immunocompromised patients , where latent virus can enter into the lytic cycle causing cytolytic destruction of host cells .',
  'In contrast , cytomegalovirus has become of increased importance in view of the large number of patients immunosuppressed for transplantation and cancer therapy ; bacterial growth in blood components appears to be increasingly common ; and Chagas disease is likely to become a serious transfusion problem in this country .',
  'Primary or recurrent viral infections , especially by herpetoviridae , with viraemias -- after organ transplants , for example -- are a serious medical problem which can affect the prognosis for survival .',
  'Infection with human cytomegalovirus ( HCMV ) is a serious medical problem , particularly in immunocompromised individuals and neonates .',
  'For immunocompromised hosts , human cytomegalovirus ( CMV ) can be a serious problem .',
  'While resistance is not a serious issue for immunocompetent individuals , it is a real concern for immunocompromised patients , especially those with AIDS and the ones that have undergone organ transplantation .',
  'We consider VZV reactivation a serious concern in the autologous transplant setting , requiring extended prophylaxis .',
  'Infection with human cytomegalovirus ( HCMV ) is a serious medical problem , particularly in immunocompromised individuals and neonates .',
  'Notably , HCMV infection is a serious , sometimes life-threatening medical problem for newborns and immunosuppressed individuals , including transplant recipients and patients under antitumoral chemotherapy .',
  'Cytomegalovirus retinitis remains a serious problem in AIDS patients , and the species specificity of human cytomegalovirus ( HCMV ) has hindered the development of animal models suitable for testing new therapeutic agents .',
  'Polyomavirus BK-associated nephropathy ( BKVN ) has been a serious problem after kidney transplantation .',
  'Resistance to antiviral drugs can be a severe problem in transplant recipients .',
  'Viral infections are still a serious diagnostic and therapeutic problem in patients undergoing alternative donor transplants .',
  'In recent years , BK virus ( BKV ) nephritis after renal transplantation has become a severe problem .'],
 'hypertension': ['High blood pressure is related to cardiovascular diseases.',
  'Hypertension is one of the most common diseases around the world, which is the most risk factor related to cardiovascular disease',
  'Pulmonary arterial hypertension (PAH) was previously considered an illness that affects mostly the young, but now it is also increasingly recognized in the elderly',
  'In our point of view , the problem with using blood pressure as a measurement is that it can be affected by many other factors unrelated to cardiac denervation .',
  'However , the problem with clinical use of baPWV is that the index itself is closely dependent on blood pressure .',
  'The problem with understanding primary ( genetic ) hypertension in man is that several genes are involved in the cardiovascular control mechanisms and that the genetics are complex .',
  'Arterial hypertension remains to be a serious problem with considerable morbidity and mortality worldwide in the present age .',
  'Failure to intensify therapy when indicated is a serious problem in the management of hypertension .',
  "In China , hypertension is a serious public health problem , but few studies have evaluated the effectiveness of hypertension management in China 's primary healthcare system .",
  'Racial health disparities related to hypertension in African Americans are a serious public health concern that warrants greater attention .',
  'Hypertension is a serious public health problem .',
  'Hypertension is a serious worldwide public health problem .',
  'Hypertension is a serious health problem in Western society , in particular for the African-American population .',
  'The increased application of VEGFR-TKIs means that the probability of hypertension is a serious concern .',
  'High blood pressure ( BP ) is a serious , common and growing global public health problem .',
  'Lack of convincing data on prognosis of patients whose antihypertensive treatment has been guided by 24-hour BP monitoring also presents a serious problem .',
  'Hypertension is a serious public health problem worldwide .',
  'Arterial hypertension represents a serious medical , social and economic problem in Poland .',
  'Hypertension is a serious global health problem .',
  'Hypertension is a serious public health problem in many societies due to its high prevalence and the associated increases in the risks of cardiovascular and renal disease .',
  'Despite multidrug antihypertensive therapy severe hypertension is still a serious problem in patients on RRT .',
  'Resistant hypertension defined as failure to reach blood pressure targets despite treatment with three antihypertensive drugs including a diuretic represents a serious clinical problem .',
  'Essential hypertension is considered a serious health problem and diet can play an important role in its prevention and treatment .',
  'Hypertension is a serious problem in Brazil that is associated with chronic illness controlled , in part , by consistent adherence to medications .',
  'Although high blood pressure and related risk factors were formerly a serious problem in Japan , blood pressure levels have decreased in schoolchildren from Iwata over the past 15 years .',
  'Hypertension is also a serious public health problem worldwide , one that , along with type 2 diabetes , is growing due to increases in both life expectancy and obesity .',
  'Hypertension among Asian-Americans is a serious public health concern , requiring culturally sensitive best practices , and evidence-based approaches to improve prevention and control among Asians .',
  'Hypertension , with a prevalence of 25.6 % is a serious public health concern in Iran .',
  'Hypertension is a serious public health problem in China and in other developing countries .',
  'In Venezuela , hypertension is a serious public health problem exacerbated by age and overweight .',
  'Hypertension seems to be a serious public health problem in Greece .',
  'Raised blood pressure in Vietnam is a serious problem due to its magnitude and the unacceptably high unawareness rate in the population .',
  'Inadequate blood pressure ( BP ) control remains a serious concern worldwide .',
  'Pulmonary hypertension continues to be a serious clinical problem with high mortality .',
  'African Americans shoulder significant disparities related to hypertension ( HTN ) , which is a serious public health problem in the city of Detroit , Michigan , where more than 80 % of the population is African American .',
  'Comorbidity of essential hypertension and type 2 diabetes is a serious problem connected with early affection of target organs and further cardiovascular complications .',
  'Arterial hypertension ( AH ) is a serious social and medical problem of our time .',
  'Arterial hypertension is a serious health problem .',
  'Hypertension is one of the most important causes of cardiovascular and renal morbidity and mortality , and it represents a serious health problem in Western countries .',
  'Systemic arterial hypertension ( SAH ) or high blood pressure a serious global public health problem marked by social inequalities .',
  'Thirty percent ( 30 % ) of participants believed hypertension was not a serious problem .',
  'Severe hypertension in childhood is a life-threatening clinical problem that carries with it not only serious sequelae of inadequate treatment but equally serious complications of over enthusiastic therapy .',
  'Hypertension is a serious world-wide health problem as it increases cardiovascular atherosclerotic risk , stroke and attending morbidity and mortality .',
  'Hypertension has not proved to be a serious general problem in the EPO treated patient .',
  'Hypertension is a serious medical problem affecting millions of people worldwide .',
  'Hypertension is a major risk factor for cardiovascular disease , which is a serious health problem in the highly industrialized countries .',
  '4 . Errors in indirect measurement of blood pressure are a serious problem , particularly in the elderly .',
  'Arterial hypertension represents a serious public health problem , being a major cause of morbidity and mortality worldwide .',
  'Hypertension ( HTN ) is a serious and often unrecognized health problem among batey residents .',
  'Elevated blood pressure is a serious problem in the United States .',
  'Arterial Hypertension remains a serious public health problem in Spain , given its high degree of prevalence ( 20 % to 30 % of individuals suffer from hypertension , the figure increasing with age ) and contributes to the main cause of death in the country , that being cardiovascular disease .',
  'Arterial hypertension is a serious health problem affecting mainly the elderly population .',
  'Hypertension is a clinical disease with a prevalence sufficiently high in acculturated societies to warrant it being designated a serious public health problem .',
  'Hypertension is a serious public health problem in Singapore and is associated with significant morbidity and mortality from cardiovascular disease ( CVD ) with considerable implications for health-care resources .',
  'A severe problem in patients with SCD and PNH is pulmonary and systemic hypertension .',
  'Hypertension ( HTN ) and its cardiovascular complications such as stroke and heart failure are a serious public health problem around the world .',
  'Furthermore , 73 % of hypertensives believed hypertension was not a serious problem , and required no regular medication .',
  'Hypertension ( HTN ) is a serious health problem that threatens one fourth of the adult population in some countries .',
  'Hypertension ( HTN ) continues to be a serious public health problem in the United States and is a major risk factor for stroke , heart failure , myocardial infarction , and other serious cardiovascular and renal diseases .',
  'Noncompliance with follow-up is a serious problem in the management of hypertension .',
  'Hypertension is a serious public health concern with inadequate control of blood pressure ( BP ) worldwide .',
  'Hypertension is considered a serious health problem worldwide .',
  'Hypertension is a serious public health concern as it contributes to a significant burden of disease , leading to millions of deaths globally .',
  'The high prevalence of hypertension among Mongolian people can be a serious health problem in this country .',
  'Hypertension is a serious public health problem worldwide .',
  'Hypertension is a serious health problem particularly for African-Americans .',
  'Pharmacotherapy of resistant arterial hypertension represents a serious problem , because today there are no clear algorithms of action in this clinical situation .',
  'Due to its frequent occurrence in diabetics , hypertension is a serious problem from the aspect of its effect on cardiovascular morbidity and mortality .',
  'Hypertension is a serious medical , social and economical problem .',
  'If the expense or side effects of antihypertensive drug therapy become a serious problem , dietary therapy can be a worthwhile option .',
  'Arterial hypertension is a serious public health problem because of its frequency and poor management .',
  'Hypertension , a chronic medical condition of increased blood pressure , is a serious public health problem .',
  'Hypertension is a serious health problem due to high frequency and concomitant other diseases including cardiovascular and renal dysfunction .',
  'Hypertension represents a serious public health problem and is one of the most frequent causes of morbidity around the world .',
  'Under- treatment and under diagnosis of hypertension : a serious problem in the United Arab Emirates .',
  'Hypertension represents a serious problem in Romania , as there are over 3 million hypertensive people in our country .',
  'Hypertension is a serious global public health problem , affecting approximately 600 million people worldwide .',
  'Hypertension is a serious global public health problem that affects a large part of the Brazilian adult population and can cause limitations and losses of quality of life .',
  'Hypertension is the primary risk factor for cardiovascular disease that constitutes a serious worldwide health concern and a significant healthcare burden .'],
 'ibd': ['Gastrointestinal symptoms seem to affect more women, due to hormonal and emotional issues, impacting the quality of life.',
  'Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food',
  'Gastroenterological and rheumatological diseases often have a systemic character, with disease manifestations beyond the area affected by the disease',
  'Inflammatory bowel disease is a\xa0complex and challenging disease',
  'Diverticular disease is becoming increasingly more common in the western world',
  'IgG4-related disease (IgG4-RD) is a tumefactive fibro-inflammatory lesion that can affect any organ system in the body',
  'Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders with chronic abdominal pain and altered bowel habit without any organic reason',
  'A major drawback of oral treatment of inflammatory bowel disease ( IBD ) is the non-specific distribution of drugs during long-term treatment .',
  "Stricturing Crohn 's disease ( CD ) is a severe phenotype that presents unique challenges to therapeutic management .",
  'Inflammatory bowel disease ( IBD ) is a serious public health problem worldwide .',
  'Inflammatory bowel disease ( IBD ) is a serious health concern among western societies .',
  'Inaccessibility to medications is a serious problem for IBD patients after city shutdown .',
  "A severe clinical phenotype along with concern for ensuring normal growth and development has a major impact on treatment choices for children newly diagnosed with Crohn 's disease ( CD ) .",
  "Inflammatory bowel disease ( IBD ) , including Crohn 's disease and ulcerative colitis , is a serious , costly , and persistent health problem with an estimated prevalence in Western countries around 0.5 % of the general population ; its socioeconomic impact is comparable with that for chronic diseases such as diabetes .",
  'In particular , chronic visceral pain , the central symptom of functional gastrointestinal disorders such as irritable bowel syndrome , is a serious clinical problem that affects a high percentage of the world population .',
  'A global increase in the prevalence of metabolic syndromes and digestive tract disorders , like food allergy or inflammatory bowel disease ( IBD ) , has become a severe problem in the modern world .',
  'Thus irritable bowel syndrome has become a serious socio-economic problem that affects the family and the workplace .',
  'Currently , inflammatory bowel disease ( IBD ) is a serious public health problem on the rise worldwide .',
  'Reactivation of latent tuberculosis ( TB ) in inflammatory bowel disease ( IBD ) patients treated with antitumor necrosis factor-alpha medication is a serious problem .',
  'We now know that significant numbers of patients with SpA have associated clinical IBD and almost half of them show subclinical gut inflammation , yet the connection between the gut and the musculoskeletal system has remained a vexing problem .',
  "Treatment refractoriness is a severe problem in the management of patients with ulcerative colitis and Crohn 's disease .",
  'Irritable bowel syndrome ( IBS ) is a serious health problem that affects an estimated 10 - 15 % of people worldwide and has economic consequences in the United States of over $ 30 billion annually .',
  "Our results show that malnutrition is a serious problem also in outpatients with Crohn 's disease .",
  'Non-adherence to anti-tumour necrosis factor [ TNF ] agents in patients with inflammatory bowel disease [ IBD ] is a serious problem .',
  'Inflammatory bowel disease is a serious health problem .'],
 'crohn': ['Gastrointestinal symptoms seem to affect more women, due to hormonal and emotional issues, impacting the quality of life.',
  'Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food',
  'Gastroenterological and rheumatological diseases often have a systemic character, with disease manifestations beyond the area affected by the disease',
  'Inflammatory bowel disease is a\xa0complex and challenging disease',
  'Diverticular disease is becoming increasingly more common in the western world',
  'IgG4-related disease (IgG4-RD) is a tumefactive fibro-inflammatory lesion that can affect any organ system in the body',
  'Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders with chronic abdominal pain and altered bowel habit without any organic reason',
  'A major drawback of oral treatment of inflammatory bowel disease ( IBD ) is the non-specific distribution of drugs during long-term treatment .',
  "Stricturing Crohn 's disease ( CD ) is a severe phenotype that presents unique challenges to therapeutic management .",
  'Inflammatory bowel disease ( IBD ) is a serious public health problem worldwide .',
  'Inflammatory bowel disease ( IBD ) is a serious health concern among western societies .',
  'Inaccessibility to medications is a serious problem for IBD patients after city shutdown .',
  "A severe clinical phenotype along with concern for ensuring normal growth and development has a major impact on treatment choices for children newly diagnosed with Crohn 's disease ( CD ) .",
  "Inflammatory bowel disease ( IBD ) , including Crohn 's disease and ulcerative colitis , is a serious , costly , and persistent health problem with an estimated prevalence in Western countries around 0.5 % of the general population ; its socioeconomic impact is comparable with that for chronic diseases such as diabetes .",
  'In particular , chronic visceral pain , the central symptom of functional gastrointestinal disorders such as irritable bowel syndrome , is a serious clinical problem that affects a high percentage of the world population .',
  'A global increase in the prevalence of metabolic syndromes and digestive tract disorders , like food allergy or inflammatory bowel disease ( IBD ) , has become a severe problem in the modern world .',
  'Thus irritable bowel syndrome has become a serious socio-economic problem that affects the family and the workplace .',
  'Currently , inflammatory bowel disease ( IBD ) is a serious public health problem on the rise worldwide .',
  'Reactivation of latent tuberculosis ( TB ) in inflammatory bowel disease ( IBD ) patients treated with antitumor necrosis factor-alpha medication is a serious problem .',
  'We now know that significant numbers of patients with SpA have associated clinical IBD and almost half of them show subclinical gut inflammation , yet the connection between the gut and the musculoskeletal system has remained a vexing problem .',
  "Treatment refractoriness is a severe problem in the management of patients with ulcerative colitis and Crohn 's disease .",
  'Irritable bowel syndrome ( IBS ) is a serious health problem that affects an estimated 10 - 15 % of people worldwide and has economic consequences in the United States of over $ 30 billion annually .',
  "Our results show that malnutrition is a serious problem also in outpatients with Crohn 's disease .",
  'Non-adherence to anti-tumour necrosis factor [ TNF ] agents in patients with inflammatory bowel disease [ IBD ] is a serious problem .',
  'Inflammatory bowel disease is a serious health problem .'],
 'fungal': ['Topical onychomycosis therapies are usually inadequate, and patient compliance to systemic therapies is poor.',
  'Onychomycosis is a common but difficult to treat nail disorder.',
  'Immunoprecipitin detection ( IPD ) is the current reference confirmatory technique for anti-Aspergillus antibody detection ; however , the lack of standardization is a critical drawback of this assay .',
  'These results are important for infection control committee in the hospital because invasive fungal diseases can make a serious problem for patients that hospitalized in ICU .',
  'Invasive fungal infections , a serious problem among cancer patients , are increasing in incidence , and can cause morbidity and mortality .',
  'In addition , this analysis suggests that antineoplastic agents and derivatives might find novel indications in the treatment of fungal infections , for which few agents are presently available , toxicity remains a serious concern , and drug resistance is emerging .',
  'Recently , with increasing medical practices , including organ transplantation and tumor chemotherapy , fungal infections , particularly the occurrence of drug-resistant fungal strains , remain a severe problem for the public health , which cause worse complications in the immunocompromised patients .',
  'The diagnosis of mycotic infections still remains a serious problem .',
  'Our results seem to confirm that fungal air spores , because of its quantity and variety , can represent a serious problem for human health in Sardinia .',
  'A respiratory fungal infection is a severe clinical problem caused by endemic or opportunistic fungi .',
  'Fungal infections constitute a serious clinical problem in the group of patients receiving total parenteral nutrition .',
  'Fungal infections represent a serious problem for patients with immune systems compromized either by HIV infection , or administration of immunosuppressive drugs during cancer therapy and organ transplantation .',
  'Invasive aspergillosis has become a serious problem in clinical practice , but the actual factor that confers virulence on the fungus has not been thoroughly elucidated .',
  'The incidence of fungal infections is considered a serious public health problem worldwide .',
  'Fungal infections have become a serious medical problem due to the high infection rate and the frequent emergence of drug resistance .',
  'Ophthalmic mycoses caused by infectious fungi are being recognized as a serious concern since they lead to total blindness .',
  'Respiratory fungal infection is a severe clinical problem , especially in patients with compromised immune functions .',
  'Enteric cryptosporidiosis is a severe problem in advanced stages of HIV infection .',
  'Infections caused by filamentous fungi are rising in incidence and became a serious health concern .',
  'Invasive fungal infections raise a serious concern related to their morbidity and mortality .',
  'Suppurative corneal ulcers due to filamentous fungi are a serious and intractable problem in many tropical developing countries .',
  'Since 1980s , however , the incidence of tinea capitis has increased to become a serious medical problem both in America and in some parts of Europe .',
  'Paracoccidioidomycosis ( PCM ) , a human mycosis caused by the dimorphic fungus Paracoccidioides brasiliensis , is a serious public health problem in several countries of Latin America .',
  'Invasive aspergillosis is a serious problem for immunocompromised patients , especially if neutropenic .',
  'Cryptosporidiosis continues to be a serious problem in immunocompromised patients and on a worldwide scale in undernourished infants and children .',
  'Invasive fungal infections have become a serious problem in the critically ill .',
  'Invasive aspergillosis ( IA ) is a severe life-threatening infection with challenges in therapy .',
  'Nowadays , infections caused by fungi and protists constitute a serious problem for public health services .',
  'Cryptosporidium is a serious problem among patients with acquired immuno-deficiency syndrome ( AIDS ) .',
  'The unpleasant smell of infected fungating tumors and benign cutaneous ulcers is a distressing clinical problem , known to be associated with anaerobic infection .',
  'The number of fungal infections has increased dramatically , and those involving the eye pose a serious problem and treatment challenge to practicing physicians .',
  'Fungal keratitis is a serious problem affecting the agrarian poor and hence requires attention from public health specialists .',
  'Pulmonary fungal infection of community-acquired origins is becoming a serious problem .',
  'While relatively uncommon , fungal infections present a serious concern given a high association with adverse events including death .',
  'Fungal infections have become a serious medical problem due to the high infection rate and the frequent emergence of drug resistance .',
  'Invasive pulmonary aspergillosis is a serious problem in the treatment of patients with acute leukemia .',
  'Invasive fungal infections ( IFIs ) are a life-threatening problem in immunocompromised patients .',
  'Fungal infections are a serious health problem .',
  'Rare and emerging opportunistic fungal pathogens are a serious and growing concern for immunosuppressed patients .',
  "Toenail onychomycosis is still a serious medical problem , which can significantly reduce the patient 's quality of life .",
  'During the last three decades systemic fungal infections associated to immunosuppressive therapies have become a serious healthcare problem .',
  'The cytologic diagnosis of ASCUS is a serious dilemma both clinical and considerable economic problem .',
  'Among fungal infections , dermatophytoses constitute a serious public health problem , affecting 20 - 25 \xa0 % of the world population .',
  'Fungal infections are a serious health problem in clinics , especially in the immune-compromised patient .',
  'Fungal infections are still underappreciated and their prevalence is underestimated , which renders them a serious public health problem .',
  'Fungal nosocomial infections continue to be a serious problem among hospitalized patients , decreasing quality of life and adding millions of euros to healthcare costs .',
  'Fungal infection is a severe problem in children suffering from cancer .',
  'Over the last few years , fungal infections have emerged as a worrisome global public health problem .',
  'Cryptosporidium is a worldwide waterborne parasite and the treatment is a severe problem in immunocompromised patients .',
  'Fungal infections represent a serious health problem especially in immunocompromised individuals .',
  'Invasive Aspergillosis ( IA ) is a serious problem among hematological patients and it is associated with high mortality .',
  "A severe problem is provided by the so-called opportunistic fungi which become parasitic only after the host 's immunological protection has been impaired by predisposing factors .",
  'Fungal infections present a serious concern given the high association with major adverse events including death in this group of patients .',
  'Fungal infections are an important cause of morbidity and pose a serious health concern especially in immunocompromised patients .',
  'Fungal infections remain a serious problem worldwide that require effective therapeutic strategies .',
  'Systemic fungal infections pose a serious clinical problem .',
  'Fungal infections caused by yeasts have increased during the last decades and invasive forms represent a serious problem for human health .',
  "Fungus infection in hematologic cancer patients was a serious problem in the two periods , but it became more important in the late 1980 's .",
  'Cryptosporidium , an important cause of diarrhoea , has been reported worldwide both in immunocompetent and immunocompromised individuals and has emerged as a serious public health problem .',
  'Fungal infections have became a serious medical problem due to their high incidence and mortality .',
  'Fungal infections represent a serious health problem in industrialized countries .',
  'Infections by opportunistic pathogenic fungi , especially Candida species , Cryptococcus neoformans , and Aspergillus fumigatus , are a serious medical problem in immunocompromised patients .',
  'In recent years , fungal infections have become a serious health problem .',
  'Invasive fungal sinonasal disease is a life-threatening problem in immunocompromised children , especially with relapsed leukemia .',
  'Cryptococcosis is still a life-threatening mycosis that continues to be of serious concern in Latin American countries , especially among HIV+positive population .',
  'Fungal infection with opportunistic fungi can cause a serious problem for immunocompromised persons such as organ-transplant recipients , cancer , and HIV/AIDS patients .',
  'Invasive aspergillosis ( IA ) is a serious problem in patients suffering from hematological malignancies .',
  'Microsporum canis infection of the scalp remains a serious epidemiological problem in R. Macedonia .',
  'Among infectious diseases , fungal infections , in particular aspergillosis , remain a serious problem in CGD patients .',
  'Fungal contamination of materials is a serious human health problem because the fungal cells scatter from the materials in the air or HD .',
  'Fungal contamination of dialysis fluids may be a serious problem in therapy , particularly due to the debilitated immune system of haemodialysis patients .',
  'Emerging fungal infections represent a serious problem in an immunocompromised host .',
  'Aspergillus fumigatus is the leading cause of invasive mold infection and is a serious problem in immunocompromised populations worldwide .',
  'Fungal infection in severely burned patients is a serious problem due to various factors , such as the extensive application of antibiotics .',
  'Fungal infections are a serious problem among haemodialysis patients .',
  'In the late 1960s , the management of fungal keratitis was a serious unresolved problem .',
  'Invasive fungal infection ( IFI ) is a serious problem due to difficulties in early diagnosis and high mortality .',
  'Fungal infections , especially invasive types , have become a serious healthcare problem as the immunocompromised population increases .',
  'A retrospective review of a five year period ( 1994 - 1998 ) revealed that opportunistic mycoses caused by ubiquitous fungal pathogens are a serious problem in the immunocompromised patient population of Kuwait .',
  'Fungal infections , especially those caused by antibiotic resistant pathogens , have become a serious public health problem due to the growing number of immunocompromised patients , including those subjected to anticancer treatment or suffering from HIV infection .',
  'Is Microsporum canis infection about to become a serious dermatological problem ?'],
 'burnout': ['Palliative care health professionals have reported high levels of burnout.',
  'Burnout, depression, and suicide among health care professionals and learners have reached a rampant level',
  'As the responsibilities of nurse leaders become increasingly complex, there is concern that job satisfaction is becoming more difficult, and burnout and attrition more common',
  'Workload pressures were a drawback of participation for both GPs and specialists .',
  'Nurse fatigue is a serious problem with negative consequences on patient safety and nurse well-being .',
  'Burnout is a severe problem among nurses .',
  'Burnout has been recognized as a serious health problem .',
  'Workplace stress among nurses providing care for people living with human immunodeficiency virus is a serious problem in China that may increase rates of job burnout and affect quality of care .',
  'Burnout among hospital-based nurses appears to be a serious problem affecting the delivery of health care .',
  'Burnout is a serious problem for psychiatrists that has implications for clinical practice and personal health .',
  'Burnout is a serious problem among nursing staff internationally with negative impacts on the quality of care and patient safety .',
  'Burnout is a serious health problem and the cause of career disruption in 15 % of women and 9 % of men who quit their job .',
  'Nurses burnout is a serious problem which can affect their health , the quality of patient care , and health institutions .',
  'Visual fatigue of VDT ( visual display terminal ) operators poses a serious problem for corporations where VDT work is a major part of operations .',
  'Behavioral Health and Burnout Among Physician Mothers Who Care for a Person With a Serious Health Problem , Long-term Illness , or Disability .',
  'Burnout is a serious concern in graduate medical education . While enhancing resilience in trainees is considered beneficial , there are few studies showing successful interventions .',
  'Burnout is a serious concern because it can lead to psychosomatic complaints , work-associated withdrawal behaviors , and a decreased quality of care .',
  'Despite the implementation of working hour restrictions in the U.S. in 2013 , the high rate of burnout remains a serious problem .',
  'They are primarily middle-aged , family- and community-oriented , satisfied with their careers , and find that work stress is not a serious problem .',
  'Burnout among physicians , nurses , and students is a serious problem in U.S. healthcare that reflects inattentive management practices , outmoded images of the " good " provider as selflessly ignoring the care of the self , and an overarching rubric of Patient Centered Care ( PCC ) that leaves professional self-care out of the equation .',
  "The survey included 2 items from the Maslach Burnout Inventory , an item from the National Comorbidity Survey Replication about likelihood of seeking professional help for a serious emotional problem , and items developed to explore residents ' help-seeking behaviors and concerns .",
  'Nowadays , the professional burnout of paramedical personnel becomes a serious health care problem , resulting in productivity loss and medical care costs increase .',
  'Burnout is a serious problem for health care providers that has implications for clinical practice and personal health .',
  'Physician burnout : a serious concern for the medical profession .',
  'Teacher burnout is regarded as a serious problem in school settings .',
  'Burnout is a serious problem among nurses .',
  'Burnout is a serious problem that anesthesiologists face during training and in practice .',
  'Occupational burnout is both a serious health concern at both public and individual levels .',
  'Purpose Physician stress and burnout is a serious and common concern in healthcare , with over half of physicians in the USA meeting at least one criterion for burnout .',
  'Exposure to mobbing and burnout could be a serious problem for head nurses who are responsible for both the performance of the nurses and organization .',
  'Mental fatigue at work is a serious problem and can raise safety concerns especially in the transportation system .',
  'Burnout is a serious problem facing the majority of oncologists .',
  'Burnout is a serious problem in the formation of health care professionals .',
  'Psychological and emotional impairment among physicians represents a serious , widespread , and difficult problem .',
  'Occupational burnout is both a serious public and individual health concern .',
  'Burnout not only is a serious problem for physicians , but it also adversely affects the quality and safety of health care for the patients they care for .',
  'Awareness is growing that worker burnout is a serious problem in the child welfare field .',
  'Burnout is a serious problem in the profession of teaching .',
  'Moreover , the results show that high work-family conflict should not represent a serious problem when nurses have high affective commitment .',
  'Physician burnout is a serious concern for hospital leaders .',
  'Burnout is a serious problem for critical care unit workers because they are exposed to chronic psychosocial stressors , including high responsibility , advanced technology and high patient acuity .',
  'The stressors inherent to the prehospital setting may increase the likelihood of experiencing burnout and lead providers to exit the profession , representing a serious workforce and public health concern .',
  'Stress and burnout among general practitioners ( GPs ) is a serious problem .'],
 'atrial': ['Distinction of paroxysmal atrial fibrillation (PAF) from non-PAF is important in clinical practice, but this is often difficult at the time of first documented AF.',
  'In our population , permanent atrial fibrillation ( pAF ) is a serious concomitant problem in patients scheduled for open heart surgery .',
  'Atrial fibrillation constitutes a serious public health problem because it can lead to complications .',
  'The management of synchronous long-standing persistent atrial fibrillation and pulmonary lesions remains a serious surgical dilemma due to the lack of clinical data and surgical guidelines .',
  'Atrial fibrillation after inhalational lung injury : a troubling complication of a rare problem .',
  'Atrial flutter is a serious problem after surgery for congenital heart disease .',
  'Atrial fibrillation is a serious public health problem posing a considerable burden to not only patients , but the healthcare environment due to high rates of morbidity , mortality , and medical resource utilization .',
  'With more than a third of patients expected to endure the arrhythmia at any given time point , atrial fibrillation after cardiac surgery becomes a vexing problem in the postoperative care of cardiac surgery patients .',
  'Postoperative atrial fibrillation ( AF ) is a vexing problem in cardiac surgery .',
  'Atrial fibrillation is a serious problem , especially in patients on dialysis .',
  'Atrial fibrillation ( AF ) is the most common arrhythmia and has become a serious public health problem .',
  'Supraventricular tachyarrhythmia ( SVT ) such as sinus tachycardia and atrial dysrhythmia is a life-threatening problem in the period immediately following an open-heart operation .',
  'Atrial and ventricular dysrhythmias developing after cardiac operation further reduce cardiac output , posing a serious problem for postoperative management .',
  'A device has also been developed for the automatic or semiautomatic treatment of atrial fibrillation , an arrhythmia less life-threatening than ventricular fibrillation , but still a serious health problem .',
  'Permanent atrial fibrillation ( pAF ) is a serious problem in cardiac surgery : An incidence of 3.5 % among all patients scheduled for open heart surgery , 9.8 % in heart valve cases and 45.6 % among patients with severe rheumatic mitral valve ( MV ) disease was observed in our institution .',
  'During childhood in patients after surgical correction late arrhythmias mostly do not represent a severe problem , but with time , when reaching adulthood , this may be an issue .'],
 'fibrillation': ['Distinction of paroxysmal atrial fibrillation (PAF) from non-PAF is important in clinical practice, but this is often difficult at the time of first documented AF.',
  'In our population , permanent atrial fibrillation ( pAF ) is a serious concomitant problem in patients scheduled for open heart surgery .',
  'Atrial fibrillation constitutes a serious public health problem because it can lead to complications .',
  'The management of synchronous long-standing persistent atrial fibrillation and pulmonary lesions remains a serious surgical dilemma due to the lack of clinical data and surgical guidelines .',
  'Atrial fibrillation after inhalational lung injury : a troubling complication of a rare problem .',
  'Atrial flutter is a serious problem after surgery for congenital heart disease .',
  'Atrial fibrillation is a serious public health problem posing a considerable burden to not only patients , but the healthcare environment due to high rates of morbidity , mortality , and medical resource utilization .',
  'With more than a third of patients expected to endure the arrhythmia at any given time point , atrial fibrillation after cardiac surgery becomes a vexing problem in the postoperative care of cardiac surgery patients .',
  'Postoperative atrial fibrillation ( AF ) is a vexing problem in cardiac surgery .',
  'Atrial fibrillation is a serious problem , especially in patients on dialysis .',
  'Atrial fibrillation ( AF ) is the most common arrhythmia and has become a serious public health problem .',
  'Supraventricular tachyarrhythmia ( SVT ) such as sinus tachycardia and atrial dysrhythmia is a life-threatening problem in the period immediately following an open-heart operation .',
  'Atrial and ventricular dysrhythmias developing after cardiac operation further reduce cardiac output , posing a serious problem for postoperative management .',
  'A device has also been developed for the automatic or semiautomatic treatment of atrial fibrillation , an arrhythmia less life-threatening than ventricular fibrillation , but still a serious health problem .',
  'Permanent atrial fibrillation ( pAF ) is a serious problem in cardiac surgery : An incidence of 3.5 % among all patients scheduled for open heart surgery , 9.8 % in heart valve cases and 45.6 % among patients with severe rheumatic mitral valve ( MV ) disease was observed in our institution .',
  'During childhood in patients after surgical correction late arrhythmias mostly do not represent a severe problem , but with time , when reaching adulthood , this may be an issue .'],
 'arrhythmia': ['Distinction of paroxysmal atrial fibrillation (PAF) from non-PAF is important in clinical practice, but this is often difficult at the time of first documented AF.',
  'In our population , permanent atrial fibrillation ( pAF ) is a serious concomitant problem in patients scheduled for open heart surgery .',
  'Atrial fibrillation constitutes a serious public health problem because it can lead to complications .',
  'The management of synchronous long-standing persistent atrial fibrillation and pulmonary lesions remains a serious surgical dilemma due to the lack of clinical data and surgical guidelines .',
  'Atrial fibrillation after inhalational lung injury : a troubling complication of a rare problem .',
  'Atrial flutter is a serious problem after surgery for congenital heart disease .',
  'Atrial fibrillation is a serious public health problem posing a considerable burden to not only patients , but the healthcare environment due to high rates of morbidity , mortality , and medical resource utilization .',
  'With more than a third of patients expected to endure the arrhythmia at any given time point , atrial fibrillation after cardiac surgery becomes a vexing problem in the postoperative care of cardiac surgery patients .',
  'Postoperative atrial fibrillation ( AF ) is a vexing problem in cardiac surgery .',
  'Atrial fibrillation is a serious problem , especially in patients on dialysis .',
  'Atrial fibrillation ( AF ) is the most common arrhythmia and has become a serious public health problem .',
  'Supraventricular tachyarrhythmia ( SVT ) such as sinus tachycardia and atrial dysrhythmia is a life-threatening problem in the period immediately following an open-heart operation .',
  'Atrial and ventricular dysrhythmias developing after cardiac operation further reduce cardiac output , posing a serious problem for postoperative management .',
  'A device has also been developed for the automatic or semiautomatic treatment of atrial fibrillation , an arrhythmia less life-threatening than ventricular fibrillation , but still a serious health problem .',
  'Permanent atrial fibrillation ( pAF ) is a serious problem in cardiac surgery : An incidence of 3.5 % among all patients scheduled for open heart surgery , 9.8 % in heart valve cases and 45.6 % among patients with severe rheumatic mitral valve ( MV ) disease was observed in our institution .',
  'During childhood in patients after surgical correction late arrhythmias mostly do not represent a severe problem , but with time , when reaching adulthood , this may be an issue .'],
 'hiv': ['HIV negative members of serostatus discordant couples are at high risk for HIV acquisition, but few interventions are in place to target them in sub-Saharan Africa.',
  'The problem with the emergence of HIV-associated tuberculosis ( which usually occurs in young adults ) is that attention has been diverted away from the fact that , in the developed world , the elderly represent the biggest pool of tubercular disease and therefore the greatest pool of infection within the community .',
  'The qualitative research found that the intervention was thoroughly enjoyed by patients and clinicians , but a fundamental problem with it was that patients received confused messages about the relation between HIV/AIDS and other STDs .',
  'A major problem with previously utilized activating agents is that at the concentrations required for efficient HIV-1 reactivation , these stimuli trigger high-level cytokine gene expression ( hypercytokinemia ) .',
  'A major drawback of highly active antiretroviral therapy ( HAART ) is the selection of resistant mutants under suboptimal dosage , in advanced stages of disease or after pretreatment with mono- or double-combination regimens .',
  'The treatment regimen of HIV-TB coinfection is associated with a major drawback of low therapeutic concentration of drugs in lungs .',
  'A major drawback of highly active antiretroviral therapy is the selection of resistant mutants under suboptimal dosage , in advanced stages of disease or after pre-treatment with mono- or double-combination regimens .',
  'Skin and soft tissue infections among the non-human immunodeficiency virus infected immunosuppressed population are a serious and growing concern .',
  'Co-infection of tuberculosis ( TB ) and HIV is a serious problem in most developing countries and in industrialized countries , co-infection of TB and HIV is seen mainly among migrant population .',
  'AIDS is a serious public health problem .',
  'Although protease inhibitors ( PIs ) are a potent class of antiretrovirals , resistance can still develop rapidly , and multiple-PI resistance has become a serious , growing clinical problem .',
  'HIV infection rates in the developing world remain a serious problem .',
  'In only a few years , HIV/AIDS became a severe public health problem worldwide .',
  'Mother-to-child transmission ( MTCT ) of the Human Immunodeficiency -Virus ( HIV ) is a serious public health problem , contributing up to 90 % of childhood HIV infections .',
  'The countries of the Caribbean have a serious problem with HIV infection and AIDS .',
  'HIV continues to be a serious public health problem for men who have sex with women ( MSW ) , especially homeless MSW .',
  'The findings indicate that HIV/AIDS is a serious health concern facing the transgender community .',
  'HIV is a serious problem for many countries , especially where injection drug use occurs .',
  'The increase in human immunodeficiency virus ( HIV ) transmission cases poses a serious public health concern .',
  'HIV epidemic continues to be a severe public health problem and concern within USA and across the globe with about 33 million people infected with HIV .',
  'Data from 1429 men and women aged 50 years or older living in two slum areas of Nairobi are used to compare AIDS-caregivers with other caregivers and non-caregivers based on self-reported health using the World Health Organization disability assessment ( WHODAS ) score and the presence of a severe health problem .',
  'HIV infection is still a serious medical problem in CF .',
  'Acquired immunodeficiency syndrome ( AIDS ) is a serious illness and a public health crisis that merits the concern of everyone .',
  'Human immunodeficiency virus ( HIV ) and its clinical state , acquired immunodeficiency syndrome ( AIDS ) , is a serious public health problem due to its health , economic , psychologic and social consequences .',
  'Human immunodeficiency virus ( HIV ) infection continues to be a vexing problem in the pediatric population .',
  'HIV-1 protease inhibitors are effective in HIV/AIDS therapy , although drug resistance is a severe problem .',
  'The survey also found that : ( a ) although most Canadians know a lot about HIV/AIDS , there are some significant gaps in their knowledge ; and ( b ) although most Canadians think HIV/AIDS is a serious problem , the vast majority do not consider themselves to be at risk for HIV infection .',
  'Among non-HIV-infected patients , about half have a serious underlying medical problem , most commonly diabetes mellitus , malignancy , or a rheumatologic condition .',
  'AIDS is a serious , progressive problem of the Public Health Department in the province of Cadiz and predominantly affects parenteral drug addicts with a percentage higher than other Spanish series in socially unaccepted people .',
  'A vaccine could substantially impact the HIV epidemic , but inadequate uptake is a serious concern .',
  'Failure to achieve reduction in the incidence of human immunodeficiency virus among men who have sex with men : A worrisome global concern .',
  'HIV/AIDS is a serious problem in sub-Saharan Africa .',
  'Introduction HIV infection continues to be a serious health concern globally .',
  'HIV infection and the AIDS epidemic in Cambodia have become a serious problem and patients urgently need adequate diagnosis and antiretroviral therapies .',
  'Currently this disease no longer represents a serious problem , it has a minimal morbidity and no mortality ; only the group of high risk immunosupressed patients ( AIDS , HIV ( + ) , ADVEP ) shows an increase in the number of cases and management in these patients continues to be problematic .',
  "Facial Kaposi 's sarcoma is a severe psychological problem for HIV-infected patients if systemic chemotherapy or interferon therapy is not possible .",
  'With the realization that individuals with human immunodeficiency virus ( HIV ) infection often have elevated CVD risk factors , the evaluation of CVD risk for these individuals becomes a serious concern .',
  'Washington , DC , is a metropolitan city with a severe HIV epidemic and faces challenges in retaining people living with HIV ( PLWH ) in quality care .',
  'Despite its importance in HIV/AIDS prevention and treatment , HIV/AIDS Counseling and Testing ( HCT ) is low in sub-Saharan Africa , where the disease continues to be a serious public health problem .',
  'HIV is a serious public health problem for homeless populations .',
  'The pandemic spread of tuberculosis ( TB ) and human immunodeficiency virus ( HIV ) represents a serious world problem .',
  'Despite the weak prevalence of HIV infection in Benin , the increase of the number of cases with AIDS remains a serious social problem .',
  'Human immunodeficiency virus ( HIV ) infection remains a serious problem in northern Thailand .',
  'For people living with HIV , lack of adherence to antiretroviral therapy ( ART ) is a serious problem and frequently results in HIV disease progression .',
  'PCP is not a serious clinical problem in immunodeficient patients taking pentamidine prophylaxis by either route compared to the progression of clinical HIV disease and death .',
  'Despite declines in HIV prevalence among all U.S. women , HIV remains a serious concern for Black women .',
  'Mother-to-infant transmission ( MTIT ) of HIV is a serious global health concern , with over 300,000 children newly infected in 2011 .',
  'Highly active antiretroviral therapy has greatly reduced the morbidity and mortality from human immunodeficiency virus ( HIV ) infection , but AIDS continues to be a serious health problem worldwide .',
  'Emergence of multi-drug resistant HIV-1 is a serious problem for AIDS treatment .',
  'The Malawi Government recognizes HIV/AIDS as a serious public health and socioeconomic problem requiring multisectoral involvement .',
  'Drug-resistance is a serious problem for treatment of the HIV/AIDS pandemic .',
  'To this end , reactivation of latent tuberculosis infection represents a serious concern of anti-TNFalpha antibody therapy .',
  'The HIV ( human immunodeficiency virus ) epidemic in the United States remains a serious public health concern .',
  'Acquired immunodeficiency syndrome is a serious problem worldwide .',
  'Adherence appears to be a serious problem among HIV-positive adolescents .',
  'This report utilizes a case study of a young woman with advanced AIDS who presented with a severe TMA , characterized by coma and renal failure , to highlight the diagnostic and therapeutic challenges raised by complex hematologic conditions occurring in the setting of HIV .',
  'Since an undetermined number of Saudi patients have received blood imported from the United States , an outbreak of AIDS in Saudi Arabia might prove to be a serious problem in the near future .',
  'Human immunodeficiency virus ( HIV ) protease inhibitor (PI)-induced adverse effects have become a serious clinical problem .',
  'Human immunodeficiency virus ( HIV ) infection is a serious public health problem costing the lives of many people including healthcare workers worldwide .',
  'HIV is a serious problem in the USA , particularly for men who have sex with men ( MSM ) .',
  'Results showed that AIDS was perceived as a serious social problem in the township , but was perceived as less serious than crime and not different from violence and unemployment .',
  'Gastrointestinal dysfunction is a serious problem in many children infected with human immunodeficiency virus ( HIV ) , the etiology of which has not been clearly defined .',
  'Opportunistic infections represent a serious health problem for HIV-infected people .',
  'Drug resistance is a severe problem in HIV treatment .',
  'Without specifically targeted interventions , the heterosexual spread of HIV in urban areas will continue to be a serious problem .',
  'Antiretroviral resistance has long been a serious problem in Thailand .',
  'Acquired immunodeficiency syndrome ( AIDS ) is a serious disease that has special concern for the health care provider .',
  'HIV infection is common and a severe problem in Thailand .',
  'The risk for occupational exposure to HIV is a serious public health problem that is well characterized in the developed world , but less so in the developing countries such as Ghana .',
  'The transmission of drug-resistant HIV is a serious problem that merits further attention by public health officials as well as virologists and clinicians .',
  'The present paper provides an account of the results of ongoing comprehensive studies conducted in the north-eastern states of India on drug-related HIV infection , already a serious problem , but possibly still restricted to that region of the country .',
  'Emergence of human immunodeficiency virus ( HIV ) drug resistance mutations prior to highly active antiretroviral therapy is a serious problem in clinical management of HIV/AIDS .',
  'Potential bridging of HIV transmission from IDU to non-IDU populations is a serious concern .',
  'Contamination by HIV present at undetectable levels at the time of testing is a serious problem .',
  'Human immunodeficiency virus type 2 ( HIV-2 ) infection is a serious problem in West Africa and Asia .',
  'Reactivation tuberculosis ( TB ) is a serious problem in immunocompromised individuals , especially those with human immunodeficiency virus ( HIV ) coinfection .',
  'HIV-seroconversion during pregnancy is a serious concern throughout South Africa , where an estimated 35 to 40 % of pregnant women have HIV/AIDS and drop-out is high at all stages of the prevention-of-mother-to-child-transmission ( PMTCT ) process .',
  'The human immunodeficiency virus ( HIV-1 ) is a retrovirus causing acquired immunodeficiency syndrome ( AIDS ) , which has become a serious problem across the world and',
  'The multiple sexual contacts in the society , especially , among non migrant females of this region are indicating the distortion of traditions and cultures which are a serious concern and may lead to HIV infection on the rise .',
  'The interaction between HIV and M. tuberculosis infection poses a serious health problem which will result in a major increase in disease , death and health care service needs in many countries .',
  'AIDS is a serious public health problem for IVDAs in the United States and Europe .',
  'In many developing countries , because the prevalence of maternal HIV infection is high ( more than 30 % in some sub-Saharan African countries ) and the resources commonly used to prevent transmission in developed countries are generally not available , transmission of HIV from mother to infant is a devastating problem .',
  'The HIV/AIDS epidemic is a serious public health problem in Mozambique .',
  'Mental health of HIV-infected patients : A severe , but Overlooked Problem .',
  'Given the importance of procreation and the lack of assisted reproduction to avoid partner transmission , members of these couples are faced with a serious dilemma even after the challenge of disclosing their HIV status to their spouses .',
  'Human immunodeficiency virus ( HIV ) infection has become a serious health problem for low-income African American women in their childbearing years .',
  'Since HIV has evolved from being a fatal illness to a chronic condition , this brings new challenges relating to long-term health , as increasing numbers of people living with HIV ( PLHIV ) navigate their lives beyond viral suppression .',
  'AIDS is a serious threat to human health and has become a global public health problem .',
  'AIDs are a serious public health problem worldwide .',
  'Acquired immunodeficiency syndrome ( AIDS ) has emerged as a serious health problem in India .',
  'Treatment failure due to the rise of drug-resistant viral strains remains a serious problem confronting HIV treaters and patients alike .',
  'The transmission of drug-resistant HIV genotypic variants is a serious problem that merits further attention by public health officials , virologists , and clinicians .',
  'As a kind of widely distributed disease in China , acquired immune deficiency syndrome ( AIDS ) has been quickly growing each year , become a serious problem and caused serious damage to the life and health of people and the social events of China and the world because of its high fatality rate .',
  'The HIV infection remains a serious public health concern in France and around the world .',
  'The HIV-1 epidemic in India is still growing with introduction of new strains/subtypes and this creates a serious problem for the clinician and basic science researchers to find the effective measures .',
  'HIV/AIDS is a serious public health problem in Swaziland , a small land-locked Southern African country .',
  'Drug-resistant HIV is becoming a serious problem , even in treatment-naive patients .',
  'A serious problem in the treatment of HIV infection is the emergence of drug-resistant forms of the virus .',
  'Although the incidence of HAD has markedly decreased since it has become possible to effectively control viral replication in the blood by administering highly active antiretroviral therapy , a less severe form of HAD , comprising a milder cognitive and motor disorder , is now potentially a serious problem .',
  'Acquired immunodeficiency syndrome ( AIDS ) is a serious health problem worldwide .',
  'Acquired Immunodeficiency Syndrome ( AIDS ) , caused by the Human Immunodeficiency Virus ( HIV ) , is a life-threatening disorder that persists worldwide as a severe health problem .',
  'Despite advances in treatment and prevention , HIV/AIDS remains a serious health and social problem .',
  'Body image disturbance is a distressing and interfering problem among many sexual minority men living with HIV , and is associated with elevated depressive symptoms and poor HIV self-care ( e.g. , antiretroviral therapy [ ART ] nonadherence ) .',
  'This study demonstrates that HIV infection remains a serious public health problem in rural zone .',
  'This situation poses a serious problem for low income countries , especially those with a high prevalence of human immunodeficiency virus type 1 ( HIV-1 ) infection .',
  "The acquired immunodeficiency syndrome ( AIDS ) , caused by the human immunodeficiency virus ( HIV ) , has become a serious world-wide problem because of this disease 's rapid propagation and incurability .",
  'It is argued that these findings appear to represent a serious a serious failure of clinical management requiring an urgent remedy , particularly in the light of the growing problem of HIV transmission in this group .',
  'Their lack of HIV knowledge is a serious concern because they are a vulnerable group for infection and their sexual behaviors are spreading HIV to other members of the population and across geographic areas .',
  '91.2 % considered HIV/AIDS a serious health problem .',
  'HIV infection is a serious concern in the Canadian Aboriginal population , particularly among youth ; however , there is limited attention to this issue in research literature .',
  'Injecting Drug Users ( IDUs ) have become a serious concern in public health due to their potential in HIV transmission .',
  'The approach described may be suitable for in vivo development of antiviral drugs against latent infection in macrophage-like cells which represent a serious problem in therapy of AIDS in humans .',
  "Human immunodeficiency virus causes the acquired immunodeficiency syndrome ( AIDS ) and becomes a serious world-wide problem because of this disease 's rapid propagation and incurability .",
  'Human immunodeficiency virus type 1 ( HIV-1 ) infection remains a severe public health problem worldwide .',
  'Acquired immunodeficiency syndrome ( AIDS ) , caused by human immunodeficiency virus ( HIV ) , has become , because of the rapid spread of the disease , a serious global problem and can not be treated .',
  'Increasing HIV/AIDS cases reported each year has become a serious health problem for our country .',
  'In China , migrants with acquired immunodeficiency syndrome ( AIDS ) have become a serious problem in the field of AIDS prevention .',
  'Children suffering from HIV-infection is a serious and increasing problem all over the world .',
  'Late diagnosis of human immunodeficiency virus ( HIV ) is associated with increased morbidity and mortality , and represents a serious public health concern .',
  'Infection with Human Immunodeficiency Virus is a serious public health problem costing the lives of many people including health workers .',
  'Infection with the human immunodeficiency virus ( HIV ) in the adolescent/young adult population of the United States is a serious , growing problem .',
  'Till now , AIDS , caused by the human immunodeficiency virus ( HIV ) is still a severe health problem worldwide .',
  'HIV in prisons is a serious public health concern .',
  'The human immunodeficiency virus ( HIV ) and the acquired immune deficiency syndrome ( AIDS ) represent a serious public health problem in Equatorial Guinea , with a prevalence of 6.2 % among adults .',
  'The interpretation of dual seroreactivity with human immunodeficiency virus type 1 ( HIV-1 ) and HIV-2 in blood samples is a serious problem facing AIDS researchers worldwide .',
  'HIV-associated TB is a serious public health problem in Myanmar .',
  'Despite advances in anti-retroviral therapy which has transformed HIV/AIDS from a fatal to a manageable chronic disease , increasing viral drug resistance , side effects and uneven access to anti-retroviral drugs remain considerable therapeutic challenges .',
  'Although antibiotics to inhibit bacterial growth and small compounds to interfere with the productive life cycle of human immunodeficiency virus ( HIV ) have successfully been used to control HIV infection , the recent emergence of the drug-resistant bacteria and viruses poses a serious concern for worldwide public health .',
  'Tuberculosis associated with human immunodeficiency virus ( HIV ) infection continues to represent a serious medical and public health problem .',
  'The rapid emergence of cross-resistance to the integrase strand transfer inhibitors ( INSTIs ) has become a serious problem in the therapy of human immunodeficiency virus type 1 ( HIV-1 ) infection .',
  'The co-infection of tuberculosis ( TB ) and human immunodeficiency virus ( HIV ) continue to be a severe problem in the European region .',
  'Coinfection with Mycobacterium tuberculosis and human immunodeficiency virus ( HIV ) is a serious problem , particularly in developing countries .',
  'The authors conclude that STD/HIV constitute a serious health problem in the prison system , requiring urgent preventive measures .',
  'The situation of tuberculosis ( TB ) is being modified by the human immunodeficiency virus ( HIV ) , which is increasing the occurrence of new cases and the generation of drug resistant strains , affecting not only the people infected with HIV , but also their close contacts and the general population , conforming a serious public health concern .',
  'PCP is a serious problem in non-HIV immunocompromised patients in whom survival outcomes are worse than those in HIV patients .',
  'Human immunodeficiency virus ( HIV ) is still a serious global health concern responsible for more than 25 million deaths in last three decades .',
  'AIDS was identified as a serious health problem for the world but not yet for Nigeria .',
  'In spite of all the efforts that has been made in prevention and the success of   antiretroviral therapy ( ART ) , AIDS remains a serious public health problem .',
  'Human immunodeficiency virus ( HIV ) is a serious health problem in the Russian Federation .',
  'This represents a serious public health concern given the young age of this sample and the potential need for long-term antiretroviral therapy .',
  'Even with the provision of antiretroviral therapy , undernutrition among HIV-positive children remains a serious problem .'],
 'aids': ['HIV negative members of serostatus discordant couples are at high risk for HIV acquisition, but few interventions are in place to target them in sub-Saharan Africa.',
  'The qualitative research found that the intervention was thoroughly enjoyed by patients and clinicians , but a fundamental problem with it was that patients received confused messages about the relation between HIV/AIDS and other STDs .',
  'A major problem with previously utilized activating agents is that at the concentrations required for efficient HIV-1 reactivation , these stimuli trigger high-level cytokine gene expression ( hypercytokinemia ) .',
  'A major drawback of highly active antiretroviral therapy ( HAART ) is the selection of resistant mutants under suboptimal dosage , in advanced stages of disease or after pretreatment with mono- or double-combination regimens .',
  'A major drawback of highly active antiretroviral therapy is the selection of resistant mutants under suboptimal dosage , in advanced stages of disease or after pre-treatment with mono- or double-combination regimens .',
  'Skin and soft tissue infections among the non-human immunodeficiency virus infected immunosuppressed population are a serious and growing concern .',
  'AIDS is a serious public health problem .',
  'Although protease inhibitors ( PIs ) are a potent class of antiretrovirals , resistance can still develop rapidly , and multiple-PI resistance has become a serious , growing clinical problem .',
  'HIV infection rates in the developing world remain a serious problem .',
  'In only a few years , HIV/AIDS became a severe public health problem worldwide .',
  'Mother-to-child transmission ( MTCT ) of the Human Immunodeficiency -Virus ( HIV ) is a serious public health problem , contributing up to 90 % of childhood HIV infections .',
  'The countries of the Caribbean have a serious problem with HIV infection and AIDS .',
  'HIV continues to be a serious public health problem for men who have sex with women ( MSW ) , especially homeless MSW .',
  'The findings indicate that HIV/AIDS is a serious health concern facing the transgender community .',
  'HIV is a serious problem for many countries , especially where injection drug use occurs .',
  'The increase in human immunodeficiency virus ( HIV ) transmission cases poses a serious public health concern .',
  'HIV epidemic continues to be a severe public health problem and concern within USA and across the globe with about 33 million people infected with HIV .',
  'Data from 1429 men and women aged 50 years or older living in two slum areas of Nairobi are used to compare AIDS-caregivers with other caregivers and non-caregivers based on self-reported health using the World Health Organization disability assessment ( WHODAS ) score and the presence of a severe health problem .',
  'HIV infection is still a serious medical problem in CF .',
  'Acquired immunodeficiency syndrome ( AIDS ) is a serious illness and a public health crisis that merits the concern of everyone .',
  'Human immunodeficiency virus ( HIV ) and its clinical state , acquired immunodeficiency syndrome ( AIDS ) , is a serious public health problem due to its health , economic , psychologic and social consequences .',
  'Human immunodeficiency virus ( HIV ) infection continues to be a vexing problem in the pediatric population .',
  'HIV-1 protease inhibitors are effective in HIV/AIDS therapy , although drug resistance is a severe problem .',
  'The survey also found that : ( a ) although most Canadians know a lot about HIV/AIDS , there are some significant gaps in their knowledge ; and ( b ) although most Canadians think HIV/AIDS is a serious problem , the vast majority do not consider themselves to be at risk for HIV infection .',
  'Among non-HIV-infected patients , about half have a serious underlying medical problem , most commonly diabetes mellitus , malignancy , or a rheumatologic condition .',
  'AIDS is a serious , progressive problem of the Public Health Department in the province of Cadiz and predominantly affects parenteral drug addicts with a percentage higher than other Spanish series in socially unaccepted people .',
  'A vaccine could substantially impact the HIV epidemic , but inadequate uptake is a serious concern .',
  'Failure to achieve reduction in the incidence of human immunodeficiency virus among men who have sex with men : A worrisome global concern .',
  'HIV/AIDS is a serious problem in sub-Saharan Africa .',
  'Introduction HIV infection continues to be a serious health concern globally .',
  'HIV infection and the AIDS epidemic in Cambodia have become a serious problem and patients urgently need adequate diagnosis and antiretroviral therapies .',
  'Currently this disease no longer represents a serious problem , it has a minimal morbidity and no mortality ; only the group of high risk immunosupressed patients ( AIDS , HIV ( + ) , ADVEP ) shows an increase in the number of cases and management in these patients continues to be problematic .',
  "Facial Kaposi 's sarcoma is a severe psychological problem for HIV-infected patients if systemic chemotherapy or interferon therapy is not possible .",
  'With the realization that individuals with human immunodeficiency virus ( HIV ) infection often have elevated CVD risk factors , the evaluation of CVD risk for these individuals becomes a serious concern .',
  'Washington , DC , is a metropolitan city with a severe HIV epidemic and faces challenges in retaining people living with HIV ( PLWH ) in quality care .',
  'Despite its importance in HIV/AIDS prevention and treatment , HIV/AIDS Counseling and Testing ( HCT ) is low in sub-Saharan Africa , where the disease continues to be a serious public health problem .',
  'HIV is a serious public health problem for homeless populations .',
  'Despite the weak prevalence of HIV infection in Benin , the increase of the number of cases with AIDS remains a serious social problem .',
  'Human immunodeficiency virus ( HIV ) infection remains a serious problem in northern Thailand .',
  'For people living with HIV , lack of adherence to antiretroviral therapy ( ART ) is a serious problem and frequently results in HIV disease progression .',
  'PCP is not a serious clinical problem in immunodeficient patients taking pentamidine prophylaxis by either route compared to the progression of clinical HIV disease and death .',
  'Despite declines in HIV prevalence among all U.S. women , HIV remains a serious concern for Black women .',
  'Mother-to-infant transmission ( MTIT ) of HIV is a serious global health concern , with over 300,000 children newly infected in 2011 .',
  'Highly active antiretroviral therapy has greatly reduced the morbidity and mortality from human immunodeficiency virus ( HIV ) infection , but AIDS continues to be a serious health problem worldwide .',
  'Emergence of multi-drug resistant HIV-1 is a serious problem for AIDS treatment .',
  'The Malawi Government recognizes HIV/AIDS as a serious public health and socioeconomic problem requiring multisectoral involvement .',
  'Drug-resistance is a serious problem for treatment of the HIV/AIDS pandemic .',
  'The HIV ( human immunodeficiency virus ) epidemic in the United States remains a serious public health concern .',
  'Acquired immunodeficiency syndrome is a serious problem worldwide .',
  'Adherence appears to be a serious problem among HIV-positive adolescents .',
  'This report utilizes a case study of a young woman with advanced AIDS who presented with a severe TMA , characterized by coma and renal failure , to highlight the diagnostic and therapeutic challenges raised by complex hematologic conditions occurring in the setting of HIV .',
  'Since an undetermined number of Saudi patients have received blood imported from the United States , an outbreak of AIDS in Saudi Arabia might prove to be a serious problem in the near future .',
  'Human immunodeficiency virus ( HIV ) protease inhibitor (PI)-induced adverse effects have become a serious clinical problem .',
  'Human immunodeficiency virus ( HIV ) infection is a serious public health problem costing the lives of many people including healthcare workers worldwide .',
  'HIV is a serious problem in the USA , particularly for men who have sex with men ( MSM ) .',
  'Results showed that AIDS was perceived as a serious social problem in the township , but was perceived as less serious than crime and not different from violence and unemployment .',
  'Gastrointestinal dysfunction is a serious problem in many children infected with human immunodeficiency virus ( HIV ) , the etiology of which has not been clearly defined .',
  'Opportunistic infections represent a serious health problem for HIV-infected people .',
  'Drug resistance is a severe problem in HIV treatment .',
  'Without specifically targeted interventions , the heterosexual spread of HIV in urban areas will continue to be a serious problem .',
  'Antiretroviral resistance has long been a serious problem in Thailand .',
  'Acquired immunodeficiency syndrome ( AIDS ) is a serious disease that has special concern for the health care provider .',
  'HIV infection is common and a severe problem in Thailand .',
  'The risk for occupational exposure to HIV is a serious public health problem that is well characterized in the developed world , but less so in the developing countries such as Ghana .',
  'The transmission of drug-resistant HIV is a serious problem that merits further attention by public health officials as well as virologists and clinicians .',
  'The present paper provides an account of the results of ongoing comprehensive studies conducted in the north-eastern states of India on drug-related HIV infection , already a serious problem , but possibly still restricted to that region of the country .',
  'Emergence of human immunodeficiency virus ( HIV ) drug resistance mutations prior to highly active antiretroviral therapy is a serious problem in clinical management of HIV/AIDS .',
  'Potential bridging of HIV transmission from IDU to non-IDU populations is a serious concern .',
  'Contamination by HIV present at undetectable levels at the time of testing is a serious problem .',
  'Human immunodeficiency virus type 2 ( HIV-2 ) infection is a serious problem in West Africa and Asia .',
  'HIV-seroconversion during pregnancy is a serious concern throughout South Africa , where an estimated 35 to 40 % of pregnant women have HIV/AIDS and drop-out is high at all stages of the prevention-of-mother-to-child-transmission ( PMTCT ) process .',
  'The human immunodeficiency virus ( HIV-1 ) is a retrovirus causing acquired immunodeficiency syndrome ( AIDS ) , which has become a serious problem across the world and',
  'The multiple sexual contacts in the society , especially , among non migrant females of this region are indicating the distortion of traditions and cultures which are a serious concern and may lead to HIV infection on the rise .',
  'AIDS is a serious public health problem for IVDAs in the United States and Europe .',
  'In many developing countries , because the prevalence of maternal HIV infection is high ( more than 30 % in some sub-Saharan African countries ) and the resources commonly used to prevent transmission in developed countries are generally not available , transmission of HIV from mother to infant is a devastating problem .',
  'The HIV/AIDS epidemic is a serious public health problem in Mozambique .',
  'Mental health of HIV-infected patients : A severe , but Overlooked Problem .',
  'Given the importance of procreation and the lack of assisted reproduction to avoid partner transmission , members of these couples are faced with a serious dilemma even after the challenge of disclosing their HIV status to their spouses .',
  'Human immunodeficiency virus ( HIV ) infection has become a serious health problem for low-income African American women in their childbearing years .',
  'Since HIV has evolved from being a fatal illness to a chronic condition , this brings new challenges relating to long-term health , as increasing numbers of people living with HIV ( PLHIV ) navigate their lives beyond viral suppression .',
  'AIDS is a serious threat to human health and has become a global public health problem .',
  'AIDs are a serious public health problem worldwide .',
  'Acquired immunodeficiency syndrome ( AIDS ) has emerged as a serious health problem in India .',
  'Treatment failure due to the rise of drug-resistant viral strains remains a serious problem confronting HIV treaters and patients alike .',
  'The transmission of drug-resistant HIV genotypic variants is a serious problem that merits further attention by public health officials , virologists , and clinicians .',
  'As a kind of widely distributed disease in China , acquired immune deficiency syndrome ( AIDS ) has been quickly growing each year , become a serious problem and caused serious damage to the life and health of people and the social events of China and the world because of its high fatality rate .',
  'The HIV infection remains a serious public health concern in France and around the world .',
  'The HIV-1 epidemic in India is still growing with introduction of new strains/subtypes and this creates a serious problem for the clinician and basic science researchers to find the effective measures .',
  'HIV/AIDS is a serious public health problem in Swaziland , a small land-locked Southern African country .',
  'Drug-resistant HIV is becoming a serious problem , even in treatment-naive patients .',
  'A serious problem in the treatment of HIV infection is the emergence of drug-resistant forms of the virus .',
  'Although the incidence of HAD has markedly decreased since it has become possible to effectively control viral replication in the blood by administering highly active antiretroviral therapy , a less severe form of HAD , comprising a milder cognitive and motor disorder , is now potentially a serious problem .',
  'Acquired immunodeficiency syndrome ( AIDS ) is a serious health problem worldwide .',
  'Acquired Immunodeficiency Syndrome ( AIDS ) , caused by the Human Immunodeficiency Virus ( HIV ) , is a life-threatening disorder that persists worldwide as a severe health problem .',
  'Despite advances in treatment and prevention , HIV/AIDS remains a serious health and social problem .',
  'Body image disturbance is a distressing and interfering problem among many sexual minority men living with HIV , and is associated with elevated depressive symptoms and poor HIV self-care ( e.g. , antiretroviral therapy [ ART ] nonadherence ) .',
  'This study demonstrates that HIV infection remains a serious public health problem in rural zone .',
  'This situation poses a serious problem for low income countries , especially those with a high prevalence of human immunodeficiency virus type 1 ( HIV-1 ) infection .',
  "The acquired immunodeficiency syndrome ( AIDS ) , caused by the human immunodeficiency virus ( HIV ) , has become a serious world-wide problem because of this disease 's rapid propagation and incurability .",
  'It is argued that these findings appear to represent a serious a serious failure of clinical management requiring an urgent remedy , particularly in the light of the growing problem of HIV transmission in this group .',
  'Their lack of HIV knowledge is a serious concern because they are a vulnerable group for infection and their sexual behaviors are spreading HIV to other members of the population and across geographic areas .',
  '91.2 % considered HIV/AIDS a serious health problem .',
  'HIV infection is a serious concern in the Canadian Aboriginal population , particularly among youth ; however , there is limited attention to this issue in research literature .',
  'Injecting Drug Users ( IDUs ) have become a serious concern in public health due to their potential in HIV transmission .',
  'The approach described may be suitable for in vivo development of antiviral drugs against latent infection in macrophage-like cells which represent a serious problem in therapy of AIDS in humans .',
  "Human immunodeficiency virus causes the acquired immunodeficiency syndrome ( AIDS ) and becomes a serious world-wide problem because of this disease 's rapid propagation and incurability .",
  'Human immunodeficiency virus type 1 ( HIV-1 ) infection remains a severe public health problem worldwide .',
  'Acquired immunodeficiency syndrome ( AIDS ) , caused by human immunodeficiency virus ( HIV ) , has become , because of the rapid spread of the disease , a serious global problem and can not be treated .',
  'Increasing HIV/AIDS cases reported each year has become a serious health problem for our country .',
  'In China , migrants with acquired immunodeficiency syndrome ( AIDS ) have become a serious problem in the field of AIDS prevention .',
  'Children suffering from HIV-infection is a serious and increasing problem all over the world .',
  'Late diagnosis of human immunodeficiency virus ( HIV ) is associated with increased morbidity and mortality , and represents a serious public health concern .',
  'Infection with Human Immunodeficiency Virus is a serious public health problem costing the lives of many people including health workers .',
  'Infection with the human immunodeficiency virus ( HIV ) in the adolescent/young adult population of the United States is a serious , growing problem .',
  'Till now , AIDS , caused by the human immunodeficiency virus ( HIV ) is still a severe health problem worldwide .',
  'HIV in prisons is a serious public health concern .',
  'The human immunodeficiency virus ( HIV ) and the acquired immune deficiency syndrome ( AIDS ) represent a serious public health problem in Equatorial Guinea , with a prevalence of 6.2 % among adults .',
  'The interpretation of dual seroreactivity with human immunodeficiency virus type 1 ( HIV-1 ) and HIV-2 in blood samples is a serious problem facing AIDS researchers worldwide .',
  'Despite advances in anti-retroviral therapy which has transformed HIV/AIDS from a fatal to a manageable chronic disease , increasing viral drug resistance , side effects and uneven access to anti-retroviral drugs remain considerable therapeutic challenges .',
  'Although antibiotics to inhibit bacterial growth and small compounds to interfere with the productive life cycle of human immunodeficiency virus ( HIV ) have successfully been used to control HIV infection , the recent emergence of the drug-resistant bacteria and viruses poses a serious concern for worldwide public health .',
  'The rapid emergence of cross-resistance to the integrase strand transfer inhibitors ( INSTIs ) has become a serious problem in the therapy of human immunodeficiency virus type 1 ( HIV-1 ) infection .',
  'The authors conclude that STD/HIV constitute a serious health problem in the prison system , requiring urgent preventive measures .',
  'PCP is a serious problem in non-HIV immunocompromised patients in whom survival outcomes are worse than those in HIV patients .',
  'Human immunodeficiency virus ( HIV ) is still a serious global health concern responsible for more than 25 million deaths in last three decades .',
  'AIDS was identified as a serious health problem for the world but not yet for Nigeria .',
  'In spite of all the efforts that has been made in prevention and the success of   antiretroviral therapy ( ART ) , AIDS remains a serious public health problem .',
  'Human immunodeficiency virus ( HIV ) is a serious health problem in the Russian Federation .',
  'This represents a serious public health concern given the young age of this sample and the potential need for long-term antiretroviral therapy .',
  'Even with the provision of antiretroviral therapy , undernutrition among HIV-positive children remains a serious problem .'],
 'immunodeficiency': ['HIV negative members of serostatus discordant couples are at high risk for HIV acquisition, but few interventions are in place to target them in sub-Saharan Africa.',
  'The problem with the emergence of HIV-associated tuberculosis ( which usually occurs in young adults ) is that attention has been diverted away from the fact that , in the developed world , the elderly represent the biggest pool of tubercular disease and therefore the greatest pool of infection within the community .',
  'The qualitative research found that the intervention was thoroughly enjoyed by patients and clinicians , but a fundamental problem with it was that patients received confused messages about the relation between HIV/AIDS and other STDs .',
  'The treatment regimen of HIV-TB coinfection is associated with a major drawback of low therapeutic concentration of drugs in lungs .',
  'Skin and soft tissue infections among the non-human immunodeficiency virus infected immunosuppressed population are a serious and growing concern .',
  'Co-infection of tuberculosis ( TB ) and HIV is a serious problem in most developing countries and in industrialized countries , co-infection of TB and HIV is seen mainly among migrant population .',
  'AIDS is a serious public health problem .',
  'HIV infection rates in the developing world remain a serious problem .',
  'In only a few years , HIV/AIDS became a severe public health problem worldwide .',
  'Mother-to-child transmission ( MTCT ) of the Human Immunodeficiency -Virus ( HIV ) is a serious public health problem , contributing up to 90 % of childhood HIV infections .',
  'The countries of the Caribbean have a serious problem with HIV infection and AIDS .',
  'HIV continues to be a serious public health problem for men who have sex with women ( MSW ) , especially homeless MSW .',
  'The findings indicate that HIV/AIDS is a serious health concern facing the transgender community .',
  'HIV is a serious problem for many countries , especially where injection drug use occurs .',
  'The increase in human immunodeficiency virus ( HIV ) transmission cases poses a serious public health concern .',
  'HIV epidemic continues to be a severe public health problem and concern within USA and across the globe with about 33 million people infected with HIV .',
  'Data from 1429 men and women aged 50 years or older living in two slum areas of Nairobi are used to compare AIDS-caregivers with other caregivers and non-caregivers based on self-reported health using the World Health Organization disability assessment ( WHODAS ) score and the presence of a severe health problem .',
  'HIV infection is still a serious medical problem in CF .',
  'Acquired immunodeficiency syndrome ( AIDS ) is a serious illness and a public health crisis that merits the concern of everyone .',
  'Human immunodeficiency virus ( HIV ) and its clinical state , acquired immunodeficiency syndrome ( AIDS ) , is a serious public health problem due to its health , economic , psychologic and social consequences .',
  'Human immunodeficiency virus ( HIV ) infection continues to be a vexing problem in the pediatric population .',
  'The survey also found that : ( a ) although most Canadians know a lot about HIV/AIDS , there are some significant gaps in their knowledge ; and ( b ) although most Canadians think HIV/AIDS is a serious problem , the vast majority do not consider themselves to be at risk for HIV infection .',
  'Among non-HIV-infected patients , about half have a serious underlying medical problem , most commonly diabetes mellitus , malignancy , or a rheumatologic condition .',
  'AIDS is a serious , progressive problem of the Public Health Department in the province of Cadiz and predominantly affects parenteral drug addicts with a percentage higher than other Spanish series in socially unaccepted people .',
  'A vaccine could substantially impact the HIV epidemic , but inadequate uptake is a serious concern .',
  'Failure to achieve reduction in the incidence of human immunodeficiency virus among men who have sex with men : A worrisome global concern .',
  'HIV/AIDS is a serious problem in sub-Saharan Africa .',
  'Introduction HIV infection continues to be a serious health concern globally .',
  'HIV infection and the AIDS epidemic in Cambodia have become a serious problem and patients urgently need adequate diagnosis and antiretroviral therapies .',
  'Currently this disease no longer represents a serious problem , it has a minimal morbidity and no mortality ; only the group of high risk immunosupressed patients ( AIDS , HIV ( + ) , ADVEP ) shows an increase in the number of cases and management in these patients continues to be problematic .',
  "Facial Kaposi 's sarcoma is a severe psychological problem for HIV-infected patients if systemic chemotherapy or interferon therapy is not possible .",
  'With the realization that individuals with human immunodeficiency virus ( HIV ) infection often have elevated CVD risk factors , the evaluation of CVD risk for these individuals becomes a serious concern .',
  'Washington , DC , is a metropolitan city with a severe HIV epidemic and faces challenges in retaining people living with HIV ( PLWH ) in quality care .',
  'Despite its importance in HIV/AIDS prevention and treatment , HIV/AIDS Counseling and Testing ( HCT ) is low in sub-Saharan Africa , where the disease continues to be a serious public health problem .',
  'HIV is a serious public health problem for homeless populations .',
  'The pandemic spread of tuberculosis ( TB ) and human immunodeficiency virus ( HIV ) represents a serious world problem .',
  'Despite the weak prevalence of HIV infection in Benin , the increase of the number of cases with AIDS remains a serious social problem .',
  'Human immunodeficiency virus ( HIV ) infection remains a serious problem in northern Thailand .',
  'For people living with HIV , lack of adherence to antiretroviral therapy ( ART ) is a serious problem and frequently results in HIV disease progression .',
  'PCP is not a serious clinical problem in immunodeficient patients taking pentamidine prophylaxis by either route compared to the progression of clinical HIV disease and death .',
  'Despite declines in HIV prevalence among all U.S. women , HIV remains a serious concern for Black women .',
  'Mother-to-infant transmission ( MTIT ) of HIV is a serious global health concern , with over 300,000 children newly infected in 2011 .',
  'Highly active antiretroviral therapy has greatly reduced the morbidity and mortality from human immunodeficiency virus ( HIV ) infection , but AIDS continues to be a serious health problem worldwide .',
  'The Malawi Government recognizes HIV/AIDS as a serious public health and socioeconomic problem requiring multisectoral involvement .',
  'To this end , reactivation of latent tuberculosis infection represents a serious concern of anti-TNFalpha antibody therapy .',
  'The HIV ( human immunodeficiency virus ) epidemic in the United States remains a serious public health concern .',
  'Acquired immunodeficiency syndrome is a serious problem worldwide .',
  'Adherence appears to be a serious problem among HIV-positive adolescents .',
  'This report utilizes a case study of a young woman with advanced AIDS who presented with a severe TMA , characterized by coma and renal failure , to highlight the diagnostic and therapeutic challenges raised by complex hematologic conditions occurring in the setting of HIV .',
  'Since an undetermined number of Saudi patients have received blood imported from the United States , an outbreak of AIDS in Saudi Arabia might prove to be a serious problem in the near future .',
  'Human immunodeficiency virus ( HIV ) infection is a serious public health problem costing the lives of many people including healthcare workers worldwide .',
  'HIV is a serious problem in the USA , particularly for men who have sex with men ( MSM ) .',
  'Results showed that AIDS was perceived as a serious social problem in the township , but was perceived as less serious than crime and not different from violence and unemployment .',
  'Gastrointestinal dysfunction is a serious problem in many children infected with human immunodeficiency virus ( HIV ) , the etiology of which has not been clearly defined .',
  'Opportunistic infections represent a serious health problem for HIV-infected people .',
  'Without specifically targeted interventions , the heterosexual spread of HIV in urban areas will continue to be a serious problem .',
  'Antiretroviral resistance has long been a serious problem in Thailand .',
  'Acquired immunodeficiency syndrome ( AIDS ) is a serious disease that has special concern for the health care provider .',
  'HIV infection is common and a severe problem in Thailand .',
  'The risk for occupational exposure to HIV is a serious public health problem that is well characterized in the developed world , but less so in the developing countries such as Ghana .',
  'The present paper provides an account of the results of ongoing comprehensive studies conducted in the north-eastern states of India on drug-related HIV infection , already a serious problem , but possibly still restricted to that region of the country .',
  'Potential bridging of HIV transmission from IDU to non-IDU populations is a serious concern .',
  'Contamination by HIV present at undetectable levels at the time of testing is a serious problem .',
  'Human immunodeficiency virus type 2 ( HIV-2 ) infection is a serious problem in West Africa and Asia .',
  'Reactivation tuberculosis ( TB ) is a serious problem in immunocompromised individuals , especially those with human immunodeficiency virus ( HIV ) coinfection .',
  'HIV-seroconversion during pregnancy is a serious concern throughout South Africa , where an estimated 35 to 40 % of pregnant women have HIV/AIDS and drop-out is high at all stages of the prevention-of-mother-to-child-transmission ( PMTCT ) process .',
  'The human immunodeficiency virus ( HIV-1 ) is a retrovirus causing acquired immunodeficiency syndrome ( AIDS ) , which has become a serious problem across the world and',
  'The multiple sexual contacts in the society , especially , among non migrant females of this region are indicating the distortion of traditions and cultures which are a serious concern and may lead to HIV infection on the rise .',
  'The interaction between HIV and M. tuberculosis infection poses a serious health problem which will result in a major increase in disease , death and health care service needs in many countries .',
  'AIDS is a serious public health problem for IVDAs in the United States and Europe .',
  'In many developing countries , because the prevalence of maternal HIV infection is high ( more than 30 % in some sub-Saharan African countries ) and the resources commonly used to prevent transmission in developed countries are generally not available , transmission of HIV from mother to infant is a devastating problem .',
  'The HIV/AIDS epidemic is a serious public health problem in Mozambique .',
  'Mental health of HIV-infected patients : A severe , but Overlooked Problem .',
  'Given the importance of procreation and the lack of assisted reproduction to avoid partner transmission , members of these couples are faced with a serious dilemma even after the challenge of disclosing their HIV status to their spouses .',
  'Human immunodeficiency virus ( HIV ) infection has become a serious health problem for low-income African American women in their childbearing years .',
  'Since HIV has evolved from being a fatal illness to a chronic condition , this brings new challenges relating to long-term health , as increasing numbers of people living with HIV ( PLHIV ) navigate their lives beyond viral suppression .',
  'AIDS is a serious threat to human health and has become a global public health problem .',
  'AIDs are a serious public health problem worldwide .',
  'Acquired immunodeficiency syndrome ( AIDS ) has emerged as a serious health problem in India .',
  'As a kind of widely distributed disease in China , acquired immune deficiency syndrome ( AIDS ) has been quickly growing each year , become a serious problem and caused serious damage to the life and health of people and the social events of China and the world because of its high fatality rate .',
  'The HIV infection remains a serious public health concern in France and around the world .',
  'The HIV-1 epidemic in India is still growing with introduction of new strains/subtypes and this creates a serious problem for the clinician and basic science researchers to find the effective measures .',
  'HIV/AIDS is a serious public health problem in Swaziland , a small land-locked Southern African country .',
  'Although the incidence of HAD has markedly decreased since it has become possible to effectively control viral replication in the blood by administering highly active antiretroviral therapy , a less severe form of HAD , comprising a milder cognitive and motor disorder , is now potentially a serious problem .',
  'Acquired immunodeficiency syndrome ( AIDS ) is a serious health problem worldwide .',
  'Acquired Immunodeficiency Syndrome ( AIDS ) , caused by the Human Immunodeficiency Virus ( HIV ) , is a life-threatening disorder that persists worldwide as a severe health problem .',
  'Despite advances in treatment and prevention , HIV/AIDS remains a serious health and social problem .',
  'Body image disturbance is a distressing and interfering problem among many sexual minority men living with HIV , and is associated with elevated depressive symptoms and poor HIV self-care ( e.g. , antiretroviral therapy [ ART ] nonadherence ) .',
  'This study demonstrates that HIV infection remains a serious public health problem in rural zone .',
  'This situation poses a serious problem for low income countries , especially those with a high prevalence of human immunodeficiency virus type 1 ( HIV-1 ) infection .',
  "The acquired immunodeficiency syndrome ( AIDS ) , caused by the human immunodeficiency virus ( HIV ) , has become a serious world-wide problem because of this disease 's rapid propagation and incurability .",
  'It is argued that these findings appear to represent a serious a serious failure of clinical management requiring an urgent remedy , particularly in the light of the growing problem of HIV transmission in this group .',
  'Their lack of HIV knowledge is a serious concern because they are a vulnerable group for infection and their sexual behaviors are spreading HIV to other members of the population and across geographic areas .',
  '91.2 % considered HIV/AIDS a serious health problem .',
  'HIV infection is a serious concern in the Canadian Aboriginal population , particularly among youth ; however , there is limited attention to this issue in research literature .',
  'Injecting Drug Users ( IDUs ) have become a serious concern in public health due to their potential in HIV transmission .',
  "Human immunodeficiency virus causes the acquired immunodeficiency syndrome ( AIDS ) and becomes a serious world-wide problem because of this disease 's rapid propagation and incurability .",
  'Human immunodeficiency virus type 1 ( HIV-1 ) infection remains a severe public health problem worldwide .',
  'Acquired immunodeficiency syndrome ( AIDS ) , caused by human immunodeficiency virus ( HIV ) , has become , because of the rapid spread of the disease , a serious global problem and can not be treated .',
  'Increasing HIV/AIDS cases reported each year has become a serious health problem for our country .',
  'In China , migrants with acquired immunodeficiency syndrome ( AIDS ) have become a serious problem in the field of AIDS prevention .',
  'Children suffering from HIV-infection is a serious and increasing problem all over the world .',
  'Late diagnosis of human immunodeficiency virus ( HIV ) is associated with increased morbidity and mortality , and represents a serious public health concern .',
  'Infection with Human Immunodeficiency Virus is a serious public health problem costing the lives of many people including health workers .',
  'Infection with the human immunodeficiency virus ( HIV ) in the adolescent/young adult population of the United States is a serious , growing problem .',
  'Till now , AIDS , caused by the human immunodeficiency virus ( HIV ) is still a severe health problem worldwide .',
  'HIV in prisons is a serious public health concern .',
  'The human immunodeficiency virus ( HIV ) and the acquired immune deficiency syndrome ( AIDS ) represent a serious public health problem in Equatorial Guinea , with a prevalence of 6.2 % among adults .',
  'The interpretation of dual seroreactivity with human immunodeficiency virus type 1 ( HIV-1 ) and HIV-2 in blood samples is a serious problem facing AIDS researchers worldwide .',
  'HIV-associated TB is a serious public health problem in Myanmar .',
  'Tuberculosis associated with human immunodeficiency virus ( HIV ) infection continues to represent a serious medical and public health problem .',
  'The co-infection of tuberculosis ( TB ) and human immunodeficiency virus ( HIV ) continue to be a severe problem in the European region .',
  'Coinfection with Mycobacterium tuberculosis and human immunodeficiency virus ( HIV ) is a serious problem , particularly in developing countries .',
  'The authors conclude that STD/HIV constitute a serious health problem in the prison system , requiring urgent preventive measures .',
  'The situation of tuberculosis ( TB ) is being modified by the human immunodeficiency virus ( HIV ) , which is increasing the occurrence of new cases and the generation of drug resistant strains , affecting not only the people infected with HIV , but also their close contacts and the general population , conforming a serious public health concern .',
  'PCP is a serious problem in non-HIV immunocompromised patients in whom survival outcomes are worse than those in HIV patients .',
  'Human immunodeficiency virus ( HIV ) is still a serious global health concern responsible for more than 25 million deaths in last three decades .',
  'AIDS was identified as a serious health problem for the world but not yet for Nigeria .',
  'In spite of all the efforts that has been made in prevention and the success of   antiretroviral therapy ( ART ) , AIDS remains a serious public health problem .',
  'Human immunodeficiency virus ( HIV ) is a serious health problem in the Russian Federation .',
  'This represents a serious public health concern given the young age of this sample and the potential need for long-term antiretroviral therapy .',
  'Even with the provision of antiretroviral therapy , undernutrition among HIV-positive children remains a serious problem .'],
 'melanoma': ['Shave skin biopsies are essential procedures wherein physicians diagnose dermatologic lesions.',
  'Melasma is an acquired refractory pigmentary disorder, which is a skin disease that predominantly affects females.',
  'Although the lifetime risk of melanoma is disproportionately higher in whites, blacks have a poorer overall survival with an absolute survival difference of 25%',
  'The incidence rate of melanoma in the Caucasian population is rising worldwide',
  'Uveal melanoma (UM), a rare malignant tumor of the eye, is predominantly observed in populations of European ancestry',
  'One genuine problem with using immunohistochemistry as the initial diagnostic technique is that the results may show staining patterns that can be regarded as consistent with the diagnosis of melanoma even when the diagnosis is incorrect , and the need for performing ultrastructural evaluation is never appreciated .',
  'The pigment melanin in human skin is a major defense mechanism against ultraviolet light of the sun , but darkened skin color , which is the result of increased and redistributed epidermal melanin , could be a serious aesthetic problem .',
  'Skin cancer is a serious societal problem , and public awareness outreach , including to youth , is crucial .',
  'Melanoma is the most aggressive skin cancer and a serious health problem worldwide because of its increasing incidence and the lack of satisfactory chemotherapy for late stages of the disease .',
  'Advanced and metastatic basal cell carcinomas ( BCCs ) are rare but still present a severe medical problem .',
  'Hyperpigmentations are a serious concern addressed by both the medical community and the cosmetic industry through the development of agents that block melanin biosynthesis .',
  'The notorious unresponsiveness of metastatic cutaneous melanoma to current treatment strategies coupled with its increasing incidence constitutes a serious worldwide clinical problem .',
  'Eighty-nine percent of the nurses reported that skin cancer was a serious problem , and 97 % believed that many people were at risk .',
  'Pigmentation is one of the essential defense mechanisms against oxidative stress or UV irradiation ; however , abnormal hyperpigmentation in human skin may pose a serious aesthetic problem .',
  'Melanoma will affect an estimated 73,000 new cases this year and result in 9,000 deaths , yet precise diagnosis remains a serious problem .',
  'Skin cancer represents a serious public health problem and melanoma is considered the most significant due to its high metastasis capacity .',
  'Although clinical management of melanoma has changed considerably in recent years , intrinsic treatment resistance remains a severe problem and strategies to design personal treatment regimens are highly warranted .',
  'Nonpigmented metastatic melanoma in a two-year-old girl : a serious diagnostic dilemma .',
  'Skin cancer , the most commonly diagnosed cancer in the United States , is a serious health care concern .',
  'One of the diseases that represents a serious health problem is skin cancer .',
  'Skin melanoma is by far the most lethal skin cancer , it is unpredictable by nature and presents a severe diagnostic problem .',
  'Malignant skin melanoma is a serious public health problem , especially among the elderly population .',
  'Melanin uncontrollable accumulation is a serious social problem to not only women , but also men , and causes pigment over-expression disorders such as freckles , melasma or pigmented acne scars .',
  'The stability and photochemical transformations of cosmetic preservatives in topical applications exposed to UV-light is a serious but poorly understood problem .',
  'Skin cancers including malignant melanoma which are due to UV radiation constitute a serious public health problem .',
  'Malignant melanoma remains a serious medical problem despite the extensive knowledge of the disease .',
  'Malignant melanoma represents a serious public health problem and is a deadly disease when it is diagnosed at late stage .',
  'Skin cancer is a serious concern whose incidence is increasing at an alarming rate .',
  'Skin cancer is a serious public health problem .',
  'Common skin tumors like basal- and squamous-cell carcinoma present a serious problem in modern medicine .',
  'Skin cancers are a serious health problem in the United States .',
  'Melanoma is the most common symptom of \xa0 aggressive skin cancer , and it has become a serious health concern worldwide in recent years .',
  'Melasma remains a troubling problem for physicans and patients alike .',
  'The exact skin cancer risk deriving from UVB-NB is a serious concern to be determined .',
  'However , increasing the risk of skin cancer by phototherapy is a serious concern .',
  'Melanosis observed in association with prolonged chlorpromazine therapy has become a serious problem in mental institutions .',
  'Nowadays , abnormal hyperpigmentation in human skin such as melasma , freckles , and chloasma has become a serious esthetic problem .',
  'Basal cell carcinoma ( BCC ) is the most prevalent malignancy in white individuals and continues to be a serious health problem .',
  'The severity of the skin lesions posed a serious welfare problem .',
  'Skin cancer is a serious public health problem worldwide , being incident over all five continents and affecting an increasing number of people .',
  'The UV-related skin cancers are by far the most common form of cancer among white Caucasians in the USA and Australia , and this poses a serious public health problem .'],
 'ssi': ['Superficial surgical site infections are a common post-operative complication.',
  'Postoperative immuno-suppression caused by TAH has become a serious clinical problem , due to the high incidence of infectious complications after this operation .',
  'Peripheral vascular graft infections , a serious concern after open lower extremity interventions , are treated using multiple strategies .',
  'Microbial infections from post-surgery or other medical-related procedure is a serious health problem .',
  'Laparoscopic port hole infections is a preventable problem and can also be treated by nonsurgical method .',
  'Superficial incisional surgical site infection ( SSI ) following gynecologic surgery is a serious problem for both patient and surgeon in terms of increased morbidity , length of hospital stay , anxiety , and costs .',
  'Surgical site infection ( SSI ) following caesarean section is a serious but underreported problem with an estimated incidence of 5 - 9 % .',
  'Surgical site infection ( SSI ) in colorectal cancer ( CRC ) has been a serious health care problem due to the delay of postoperative recovery .',
  'Surgical site infections ( ICHM ) remain a serious problem in the proximal GIT surgery , with incidence rates from 5 % to 26 % in planned procedures , and up to 40 % in urgent procedures .',
  'Sacral bed sores still present a serious problem in most surgery departments .',
  'Surgical site infection ( SSI ) following gynecologic oncology surgery is a severe problem for both patient and surgeon in terms of increasing morbidity , length of hospital stay , anxiety , and costs .',
  'Deep infections in the groin complicating vascular surgical procedures pose a serious problem , in the treatment of which two alternative methods are available : ( 1 ) Removal of the graft and the construction of an extra anatomic bypass ( obturator canal bypass , BYP ) , or ( 2 ) retaining the graft and achieving healing of the infected wound by various biological materials , such as omentum or an inferior rectus abdominis muscle flap ( TRP ) .',
  'Infection of surgical wounds is a severe problem .',
  'Independent of the method of stabilization , post-operative wound infection was a serious problem ( 24 % ) .',
  'Postoperative infections remain a serious concern after cesarean delivery , the most common major surgical procedure in the United States .',
  'Surgical site infection ( SSI ) remains so far a serious problem and major challenge , particularly in contaminated tissue-deficient repairing .',
  'The bacterial infections constitute a serious problem for the surgeon : the choice of antibiotic drugs is really important and , as often as possible , should be guided by antibiotic sensitivity tests .',
  'R esults ( selected corner points ): 1 ) Biological protection procedures in vascular surgery by flap coverage after meticulous debridement with or without autogenic vascular reconstruction are used to overcome infection of a vascular prosthesis , a serious problem , associated with the risk of anastomotic rupture and bleeding by transfer of immunological competence due to tissue coverage and finally to induce healing in the area of an infected vascular prosthesis .',
  'Postoperative infection is a serious problem in New Zealand and internationally with considerable human and financial costs .',
  'Infections remain a serious problem following injury .',
  'The data reported in this article support the findings of Dr. Altemeier ; that is , infections among surgical patients remain a serious problem today .',
  'Surgical site infections ( SSIs ) are a serious concern in health care , and wound contamination by endogenous skin flora is a major factor in the development of SSIs .',
  'Surgical site infection ( SSI ) is a serious public health problem due to its impacts on maternal morbidity and mortality and it can have a significant effect on quality of life for the patient .',
  'Postoperative central nervous system infection ( PCNSI ) in patients undergoing neurosurgical procedures represents a serious problem that requires immediate attention .',
  'Although surgical site infections after a craniotomy ( SSI-CRAN ) are a serious problem involving significant morbidity and costs , information on their prevention is scarce .'],
 'surgical': ['Superficial surgical site infections are a common post-operative complication.',
  'Postoperative immuno-suppression caused by TAH has become a serious clinical problem , due to the high incidence of infectious complications after this operation .',
  'Peripheral vascular graft infections , a serious concern after open lower extremity interventions , are treated using multiple strategies .',
  'Microbial infections from post-surgery or other medical-related procedure is a serious health problem .',
  'Laparoscopic port hole infections is a preventable problem and can also be treated by nonsurgical method .',
  'Superficial incisional surgical site infection ( SSI ) following gynecologic surgery is a serious problem for both patient and surgeon in terms of increased morbidity , length of hospital stay , anxiety , and costs .',
  'Surgical site infection ( SSI ) following caesarean section is a serious but underreported problem with an estimated incidence of 5 - 9 % .',
  'Surgical site infection ( SSI ) in colorectal cancer ( CRC ) has been a serious health care problem due to the delay of postoperative recovery .',
  'Surgical site infections ( ICHM ) remain a serious problem in the proximal GIT surgery , with incidence rates from 5 % to 26 % in planned procedures , and up to 40 % in urgent procedures .',
  'Sacral bed sores still present a serious problem in most surgery departments .',
  'Surgical site infection ( SSI ) following gynecologic oncology surgery is a severe problem for both patient and surgeon in terms of increasing morbidity , length of hospital stay , anxiety , and costs .',
  'Deep infections in the groin complicating vascular surgical procedures pose a serious problem , in the treatment of which two alternative methods are available : ( 1 ) Removal of the graft and the construction of an extra anatomic bypass ( obturator canal bypass , BYP ) , or ( 2 ) retaining the graft and achieving healing of the infected wound by various biological materials , such as omentum or an inferior rectus abdominis muscle flap ( TRP ) .',
  'Infection of surgical wounds is a severe problem .',
  'Independent of the method of stabilization , post-operative wound infection was a serious problem ( 24 % ) .',
  'Postoperative infections remain a serious concern after cesarean delivery , the most common major surgical procedure in the United States .',
  'Surgical site infection ( SSI ) remains so far a serious problem and major challenge , particularly in contaminated tissue-deficient repairing .',
  'The bacterial infections constitute a serious problem for the surgeon : the choice of antibiotic drugs is really important and , as often as possible , should be guided by antibiotic sensitivity tests .',
  'R esults ( selected corner points ): 1 ) Biological protection procedures in vascular surgery by flap coverage after meticulous debridement with or without autogenic vascular reconstruction are used to overcome infection of a vascular prosthesis , a serious problem , associated with the risk of anastomotic rupture and bleeding by transfer of immunological competence due to tissue coverage and finally to induce healing in the area of an infected vascular prosthesis .',
  'Postoperative infection is a serious problem in New Zealand and internationally with considerable human and financial costs .',
  'Infections remain a serious problem following injury .',
  'The data reported in this article support the findings of Dr. Altemeier ; that is , infections among surgical patients remain a serious problem today .',
  'Surgical site infections ( SSIs ) are a serious concern in health care , and wound contamination by endogenous skin flora is a major factor in the development of SSIs .',
  'Surgical site infection ( SSI ) is a serious public health problem due to its impacts on maternal morbidity and mortality and it can have a significant effect on quality of life for the patient .',
  'Postoperative central nervous system infection ( PCNSI ) in patients undergoing neurosurgical procedures represents a serious problem that requires immediate attention .',
  'Although surgical site infections after a craniotomy ( SSI-CRAN ) are a serious problem involving significant morbidity and costs , information on their prevention is scarce .'],
 'urolithiasis': ['Urolithiasis has high recurrent rate after surgical removal within 3\u2009years.',
  'In children with a history of traveling at least one episode of UTI is the most common drawback of vesicoureteral reflux .',
  'Urolithiasis is a severe problem in Turkey and more detailed epidemiological studies are needed to enlighten the pathogenetic factors of stone formation and its geographical variations .',
  'In addition , persistent residual stone fragments and possibility of infection after ESWL represent a serious problem in the treatment of stones .',
  "This meta-analysis demonstrates that in Turkey Pott 's disease remains a serious problem , causing paraplegia .",
  'We think that urolithiasis remains a serious problem in children in our country .',
  'Childhood urolithiasis is a serious problem in Turkey .',
  'During ESWL monotherapy for staghorn calculi , the formation of a stone street in the ureter is often encountered , and can be a troublesome problem .',
  'We concluded that urolithiasis is a serious problem among Iraqi children , with early onset of presentation .',
  'Nephrolithiasis is a serious problem for both patients and the health system .',
  'Lithiasis during pregnancy can be a serious problem representing a danger to both the mother and the fetus .',
  'Infectious urinary stones make a serious medical problem concerning up to 20 % of population .',
  'Urolithiasis during pregnancy is an uncommon , but a serious medical problem .',
  'The high incidence and recurrence rate contribute to making the urolithiasis a serious social problem .',
  'Uroliths are a vexing clinical problem because the recurrence rate is high .',
  'BACKGROUND : Vesicoureteral reflux ( VUR ) is a serious health problem leading to renal scarring in children .',
  'Ureterolithiasis is a serious clinical problem in small animal veterinary medicine , and management can be challenging and frustrating .',
  'Indeed , although urinary lithiasis has also been recorded for patients in Japan , the aetiology , incidence and spontaneous regression of this condition suggest that it is not a serious problem for this patient population .',
  'Urinary stone disease is a severe problem in Turkey , with high prevalence and incidence rates , which differ significantly between ethnic groups .',
  'Formation of urinary stone is a serious and debilitating problem throughout the world .',
  'Urolithiasis in pediatric population is a serious problem with the incidence increased these years .',
  'Paediatric urolithiasis remains a devastating health problem in low resource settings .'],
 'stone': ['Urolithiasis has high recurrent rate after surgical removal within 3\u2009years.',
  'In children with a history of traveling at least one episode of UTI is the most common drawback of vesicoureteral reflux .',
  'Urolithiasis is a severe problem in Turkey and more detailed epidemiological studies are needed to enlighten the pathogenetic factors of stone formation and its geographical variations .',
  'In addition , persistent residual stone fragments and possibility of infection after ESWL represent a serious problem in the treatment of stones .',
  "This meta-analysis demonstrates that in Turkey Pott 's disease remains a serious problem , causing paraplegia .",
  'We think that urolithiasis remains a serious problem in children in our country .',
  'Childhood urolithiasis is a serious problem in Turkey .',
  'During ESWL monotherapy for staghorn calculi , the formation of a stone street in the ureter is often encountered , and can be a troublesome problem .',
  'We concluded that urolithiasis is a serious problem among Iraqi children , with early onset of presentation .',
  'Nephrolithiasis is a serious problem for both patients and the health system .',
  'Lithiasis during pregnancy can be a serious problem representing a danger to both the mother and the fetus .',
  'Infectious urinary stones make a serious medical problem concerning up to 20 % of population .',
  'Urolithiasis during pregnancy is an uncommon , but a serious medical problem .',
  'The high incidence and recurrence rate contribute to making the urolithiasis a serious social problem .',
  'Uroliths are a vexing clinical problem because the recurrence rate is high .',
  'BACKGROUND : Vesicoureteral reflux ( VUR ) is a serious health problem leading to renal scarring in children .',
  'Ureterolithiasis is a serious clinical problem in small animal veterinary medicine , and management can be challenging and frustrating .',
  'Indeed , although urinary lithiasis has also been recorded for patients in Japan , the aetiology , incidence and spontaneous regression of this condition suggest that it is not a serious problem for this patient population .',
  'Urinary stone disease is a severe problem in Turkey , with high prevalence and incidence rates , which differ significantly between ethnic groups .',
  'Formation of urinary stone is a serious and debilitating problem throughout the world .',
  'Urolithiasis in pediatric population is a serious problem with the incidence increased these years .',
  'Paediatric urolithiasis remains a devastating health problem in low resource settings .'],
 'lithiasis': ['Urolithiasis has high recurrent rate after surgical removal within 3\u2009years.',
  'In children with a history of traveling at least one episode of UTI is the most common drawback of vesicoureteral reflux .',
  'Urolithiasis is a severe problem in Turkey and more detailed epidemiological studies are needed to enlighten the pathogenetic factors of stone formation and its geographical variations .',
  'In addition , persistent residual stone fragments and possibility of infection after ESWL represent a serious problem in the treatment of stones .',
  "This meta-analysis demonstrates that in Turkey Pott 's disease remains a serious problem , causing paraplegia .",
  'We think that urolithiasis remains a serious problem in children in our country .',
  'Childhood urolithiasis is a serious problem in Turkey .',
  'During ESWL monotherapy for staghorn calculi , the formation of a stone street in the ureter is often encountered , and can be a troublesome problem .',
  'We concluded that urolithiasis is a serious problem among Iraqi children , with early onset of presentation .',
  'Nephrolithiasis is a serious problem for both patients and the health system .',
  'Lithiasis during pregnancy can be a serious problem representing a danger to both the mother and the fetus .',
  'Infectious urinary stones make a serious medical problem concerning up to 20 % of population .',
  'Urolithiasis during pregnancy is an uncommon , but a serious medical problem .',
  'The high incidence and recurrence rate contribute to making the urolithiasis a serious social problem .',
  'Uroliths are a vexing clinical problem because the recurrence rate is high .',
  'BACKGROUND : Vesicoureteral reflux ( VUR ) is a serious health problem leading to renal scarring in children .',
  'Ureterolithiasis is a serious clinical problem in small animal veterinary medicine , and management can be challenging and frustrating .',
  'Indeed , although urinary lithiasis has also been recorded for patients in Japan , the aetiology , incidence and spontaneous regression of this condition suggest that it is not a serious problem for this patient population .',
  'Urinary stone disease is a severe problem in Turkey , with high prevalence and incidence rates , which differ significantly between ethnic groups .',
  'Formation of urinary stone is a serious and debilitating problem throughout the world .',
  'Urolithiasis in pediatric population is a serious problem with the incidence increased these years .',
  'Paediatric urolithiasis remains a devastating health problem in low resource settings .'],
 'liver': ['people with alcohol-related liver disease require complex treatment plans that often include the need for medication for the rest of their lives.',
  'Non-alcoholic fatty liver disease (NAFLD) is currently one of the most common chronic liver diseases especially in developed countries',
  'Another important problem associated with NASH is that presently the liver biopsy is still the gold standard in diagnosis and for disease staging and grading .',
  'However , the problem with BALs is that it is difficult to find a source of healthy hepatic cells with good liver function .',
  'A major drawback of these nonsteroidal compounds was a strong inhibition of the hepatic drug-metabolizing enzyme CYP1A2 .',
  'A rapid decline of cytochrome P450 ( CYP450 ) enzyme activities remains a drawback of rat hepatocyte-based in vitro cultures .',
  'The β-carboline alkaloid harmine is a high affinity inhibitor of DYRK1A but suffers from the drawback of inhibiting monoamine oxidase A ( MAO-A ) with even higher potency .',
  'Infection remains a drawback of parenteral nutrition ( PN ) , probably related , among other factors , to immunosuppressive effects of its lipid component .',
  'The lack of sensitivity to detect fibrosis , because of its heterogeneity is a drawback of liver biopsy ( LB ) .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a chronic liver disease and is a serious global health problem .',
  'Drug-induced hepatotoxicity is a serious problem and has repeatedly led to the withdrawal of a drug after successful launching .',
  'Drug-induced liver injury ( DILI ) due to the use of prescription and non-prescription medication by HIV-positive and HIV-negative patients is one of the main causes of acute liver failure and transplantation in Western countries and , although rare , has to be considered a serious problem because of its unforeseeable nature and possibly fatal course .',
  'Recurrent hepatocellular carcinoma after living donor liver transplantation : a preventable problem or an acceptable risk ?',
  'Liver fibrosis is a serious health problem worldwide , which can be induced by a wide spectrum of chronic liver injuries .',
  'Despite growing research , drug-induced liver injury ( DILI ) remains a serious issue of increasing importance to the medical community that challenges health systems , pharmaceutical industries and drug regulatory agencies .',
  'Hepatic encephalopathy is a serious problem in patients with liver cirrhosis and precise pathophysiological mechanisms responsible for encephalopathy are not fully understood .',
  'Therefore , protection from the injury of hepatocytes and liver is a serious concern in various clinical settings .',
  'Liver disease is a serious problem .',
  'Graft loss because of hepatitis C virus recurrence is a serious problem after liver transplantation ( LT ) , and the response to pegylated interferon ( PEG-IFN ) and ribavirin ( RBV ) is poor .',
  'This case illustrates how a severe metabolic alkalosis can result from a significant ingestion of Gaviscon , and that such presentations can give rise to diagnostic dilemma .',
  'Drug-induced toxicity , which impairs human organ function , is a serious problem during drug development that hinders the clinical use of many marketed drugs , and the underlying mechanisms are complicated .',
  'Liver fibrosis is a severe health problem , threatening the life quality and causing death , raising great concerns worldwide .',
  'Hepatic abscess is a serious surgical problem with a high mortality rate .',
  'Acute liver failure ( ALF ) remains a serious problem in critical care with a high rate of mortality .',
  'Liver fibrosis is a severe health problem worldwide , and it is characterized by the activation of hepatic stellate cells ( HSCs ) and excessive deposition of collagen .',
  'The pathways of chronic inflammation are well illustrated by nonalcoholic steatohepatitis ( NASH ) , which is of a serious concern due to its increasing prevalence in the westernized world and its direct correlation with lifestyle factors , particularly diet .',
  'Chronic liver disorders represent a serious health problem .',
  'Drug-induced liver injury ( DILI ) is a serious problem in pre-clinical stages of drug development and clinical pharmacotherapy , but the pathogenesis of DILI has not been elucidated .',
  'Liver injuries have been a serious public health problem worldwide .',
  'Graft loss due to hepatitis C ( HCV ) recurrence is a serious problem after LT .',
  'However , Fas mediated liver and chondrocyte damage is a serious problem in its clinical application .',
  'Hepatitis C virus ( HCV ) recurrence after orthotopic liver transplantation ( OLT ) remains a serious problem in the clinical management of post-oLT patients .',
  'Consequently , obesity and associated disorders such as nonalcoholic fatty liver disease constitute a serious problem .',
  'The not well known parenteral nutrition-related liver disease is a serious problem associated to short bowel and long-term parenteral nutrition ( PN ) use , and BT is also frequent in those patients .',
  'Idiosyncratic drug-induced liver injury ( iDILI ) is a serious concern in drug development .',
  'Liver disease is a serious problem affecting millions of people with continually increasing prevalence .',
  'Approximately 25 % of the adult general population is suffering from nonalcoholic fatty liver disease ( NAFLD ) , which has become a serious health problem .',
  'Liver diseases are on rise and remain a serious health problem .',
  'Nonalcoholic fatty liver disease ( NAFLD ) has become a serious public health problem worldwide ; however , the availability of information on the prevalence of NAFLD in the general pediatric population is still limited .',
  'One form of liver steatosis , namely Non-Alcoholic Fatty Liver Disease ( NAFLD ) , is a worrisome health problem worldwide characterized by intrahepatic triacylglycerol ( TG ) overaccumulation .',
  'We conclude that HCV infection is a serious health problem among kidney transplant recipients and it significantly affects the graft outcome .',
  'In current scenario of human health and diseases , drug-induced hepatic injury has been recognized as a serious and unresolved problem .',
  'Fatty liver disease ( FLD ) , associated with chronic alcohol consumption or obesity , is a serious medical problem .',
  'Cirrhosis of the liver is a serious public health problem worldwide , with regional variations determined by cultural factors and economic development .',
  'Hepatic sickness is a serious problem for human health .',
  'Drug-induced liver injury has become a serious health problem in contemporary society .',
  'Drug-induced liver injury has become a serious public health problem that can not be ignored .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious health problem affecting ~25 % of the global population .',
  'Fulminant liver failure ( FHF ) is a serious clinical problem and liver transplantation is the major intervention .',
  'Nonalcoholic steatohepatitis ( NASH ) is a serious and rapidly growing problem affecting a population that was not previously recognized as high risk .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is now the most frequent chronic liver disease that occurs across all age groups and is recognized to occur in 14%-30 % of the general population , representing a serious and growing clinical problem due to the growing prevalence of obesity and overweight .',
  'Drug-induced liver injury ( DILI ) is considered gradually as a serious public health issue , and hepatotoxicity has been regarded as the main clinical problem caused by it .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious public health concern that affects almost one third of the US population .',
  'Liver cirrhosis , which is caused by the accumulation of extracellular matrix materials , is a serious clinical problem that can progress to hepatic failure .',
  'Hepatic adverse drug reactions remain a serious concern for several drugs widely used in clinical practice .',
  'Liver fibrosis is a serious health problem which may lead to advanced liver cirrhosis and hepatocellular carcinoma .',
  'Acetaminophen (APAP)-induced acute liver failure ( ALF ) is a serious health problem in developed countries .',
  'Non-alcoholic steatohepatitis ( NASH ) is the most severe form of non-alcoholic fatty liver disease and is a serious public health problem around the world .',
  'Liver disease , involving a wide range of liver pathologies from fatty liver , hepatitis , and fibrosis to cirrhosis and hepatocellular carcinoma , is a serious health problem worldwide .',
  'In the liver transplant ( LT ) setting , these regimens are expected to have an important effect , because graft loss due to HCV recurrence is a serious problem after LT .',
  'Despite the treatment availability and monitoring , drug-induced hepatotoxicity ( DIH ) is a serious concern and can lead to discontinuation of treatment .',
  'Hepatic cirrhosis is a serious clinical problem caused by the accumulation of extracellular matrix , which can ultimately progress into hepatic failure .',
  'Idiosyncratic drug-induced liver injury ( iDILI ) is a frequent cause of acute liver injury and a serious problem in late stage drug-development .',
  'Drug-induced liver injury ( DILI ) is a severe adverse drug reaction which is of major concern to patients , clinicians and the pharmaceutical industry .',
  'Fibrosis remains a serious health concern in patients with chronic liver disease .',
  'Hepatotoxicity to isoniazid is a serious problem .',
  'Drug-induced liver injury ( DILI ) is considered a serious problem related to public health , due to its unpredictability and acute response .',
  'Liver failure is a serious problem that affects thousands of people in the United States each year .',
  'Acetaminophen ( APAP ) hepatotoxicity is a serious public health problem in western countries .',
  'Fatty liver disease associated with chronic alcohol consumption or obesity/type 2 diabetes has emerged as a serious public health problem .',
  'Recurrent hepatitis C infection in the posttransplant setting is a serious problem .',
  'The development of hepatic encephalopathy and coma hepaticum in patients with acute gastrointestinal bleeding and hepatic cirrhosis is a serious problem .',
  'Chemical liver and kidney injury have become a serious concern to human .',
  'Non-alcoholic fatty liver disease is a serious health problem linked to obesity and type 2 diabetes .',
  'Drug-induced liver injury has become a serious public health problem .',
  '[ Apropos of a fatal and delirious acute hepatitis . Current physiopathological therapeutic considerations ] .',
  'Liver toxicity is a severe problem associated with Traditional Chinese Medicine ( TCM ) .',
  'Alcoholic liver disease ( ALD ) is a serious health problem with significant morbidity and mortality .',
  'To date , no approved drugs are available for the treatment of NAFLD , despite the fact that it represents a serious and growing clinical problem in the Western world .',
  'Liver injury or dysfunction is considered as a serious health problem .',
  'Based on the experimental findings , it was indicated that the ethanol evaporation from culture plates was a severe problem reducing its toxicity in hepatocyte .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious health concern in China .',
  'Fatty liver disease is a serious health problem worldwide and is the most common cause for chronic liver disease and metabolic disorders .',
  'Liver failure ( LF ) continues to be a serious problem due to different underlying disorders .',
  'Acute liver failure is a severe liver disorder that poses considerable global challenges .',
  'Hepatitis C virus ( HCV ) recurrence is a serious problem after orthotopic liver transplantation ( OLT ) .',
  'Acute fulminant liver failure is a serious worldwide health problem .',
  'The liver performs a variety of essential functions ; hence drug-induced liver injury ( DILI ) is a serious concern that can ultimately lead to the withdrawal of a drug from the market or discontinuation of drug development .',
  'Drug-induced liver injury ( DILI ) , which is caused by drugs and herbal or dietary supplements , remains a serious concern for drug developers , regulators , and clinicians ; however , serum biomarkers utilized to detect and monitor DILI have not changed in decades and have limitations .',
  'Hepatitis C virus ( HCV ) recurrence after liver transplantation ( LT ) used to be a serious problem in the era of interferon-based treatment .',
  'Liver fibrosis is a serious health problem which is a critical cause of morbidity and mortality worldwide .',
  'The non-alcoholic fatty liver disease ( NAFLD ) has become a serious medical problem and an increasing threat to public health .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious public health problem .',
  'Liver damage through prolonged intake of high amounts of alcohol is a serious problem that affects many members of the population .',
  'Non-alcoholic fatty liver disease is a serious and growing clinical problem .',
  'Alcoholic hepatitis is a serious clinical problem ; opportune detection is transcendental for treatment and survival improvement .',
  'Chronic liver disorders represent a serious health problem , considering that 300 million people worldwide are hepatitis B virus carriers , and 8,000 - 10,000 patients per year , in the U.S. alone , die as a result of liver failure caused by hepatitis C infection .',
  'Pyogenic liver abscess , having experienced an evolving pathogenesis over the years , still remains a serious problem with significant morbidity .',
  'However , the recurrence of HCC after transplantation remains a serious problem that affects about 20 % of post-transplant cases .',
  'Chronic liver diseases are a serious health problem worldwide .',
  'However , liver fibrosis remains a serious medical concern , potentially progressing to end-stage liver cirrhosis and even death .',
  'Subclinical hepatic encephalopathy ( SHE ) is a serious clinical problem in patiens with liver damage and precise pathophisiological mechanisms resonsible for encephalopathy are not fully understood .',
  'Pyogenic liver abscess is a serious clinical problem associated with severe complications in 10 - 20 % of cases .',
  'Currently , fatty liver represents a serious public health problem in the Western world .',
  'Acetaminophen-associated liver toxicity remains a serious concern , but guidance regarding dose selection is ambiguous , and the literature describing acetaminophen efficacy and toxicity in pediatrics is limited .',
  'Chronic liver disease has gradually become a serious health problem worldwide .',
  'End-stage organ failure is a devastating problem with limited therapeutic options .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious global public health concern .',
  'Drug-induced liver injury ( DILI ) is a serious concern during drug development and the treatment of human disease .',
  'Hepatotoxicity is a serious problem during drug development and for the use of many established drugs .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is one of the most frequent causes of liver disease and its prevalence is a serious and growing clinical problem .',
  'Hepatotoxicity and acute liver failure caused by an acetaminophen overdose is a serious clinical problem in western countries .',
  'Hepatic foci are a serious economic problem for most turkey-producing areas in the United States .',
  'Hepatitis C recurrence after liver transplantation is a serious problem , leading to increased graft loss and morbidity in some individuals .',
  'The induction of human cytochrome P450 enzymes ( CYPs ) often poses a serious problem in clinical practice .',
  'Chronic hepatitis is a serious problem because the disease seems to be progressive despite prednisone therapy .',
  'The prevalence of various hepatic diseases increases dramatically worldwide and regarded as a serious health problem .',
  'Drug-induced liver injury ( DILI ) is a serious worldwide health problem that accounts for more than 50 % of acute liver failure .',
  'Chronic liver disease is a serious global health problem , and an increasing number of patients are seeking alternative medicines or complementary treatment .',
  '[ Apropos of a fatal and deliriant form of acute hepatitis . Physiopathological considerations . Current therapy ] .',
  'Alcoholic liver disease ( ALD ) is a serious liver problem in western countries .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious health problem in developed countries .',
  'Acute liver failure is a serious clinical problem of which the underlying pathogenesis remains unclear and for which effective therapies are lacking .',
  'Non-alcoholic steatohepatitis ( NASH ) has become a serious public health problem associated with metabolic syndrome .',
  'Alcoholic and non-alcoholic fatty liver diseases have become a serious concern whole over the world .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious health problem .',
  'Liver damage is a serious medical problem worldwide and is caused by primary or secondary metabolic , microbiological , toxicological , immunological and circulatory etiological factors .',
  'Acute hepatic failure is a serious problem .',
  'Intestinal failure-associated liver disease ( IFALD ) remains a serious problem in the treatment of infants with nutritional problems and short bowel syndrome .',
  "Resveratrol ( 3,5,4'-trihydroxy-trans-stilbene ) is an unfulfilled promise for health care : its exploitation is hindered by rapid conjugative metabolism in enterocytes and hepatocytes ; low water solubility is a serious practical problem .",
  'Chronic liver dysfunction or injury is a serious health problem worldwide .',
  'Human liver cancer has emerged as a serious health concern in the world , associated with poorly available therapies .',
  'Parenteral nutrition-associated liver disease remains a vexing problem .',
  'As a serious public health concern , alcohol-related liver disease is associated with dysregulations in the intestinal barrier function and the gut microbiota .',
  'Hepatic abscess ( HA ) remains a serious and often difficult to diagnose problem .',
  'The progression in nonalcoholic fatty liver disease ( NAFLD ) to nonalcoholic steatohepatitis is a serious health concern , but the underlying mechanisms remain unclear .',
  'Recurrent hepatitis C after liver transplantation is a serious problem faced by liver transplant recipients .',
  'Recurrent hepatitis C virus ( HCV ) has been a serious problem after liver transplantation ( LT ) .',
  'Evidence that progressive liver injury develops in some patients requiring lifelong total parenteral nutrition raises a serious dilemma for both patients and physicians .',
  'Amoebic liver abscess is a serious problem in Pakistan .',
  'Protein and energy malnutrition is a severe problem for patients with liver cirrhosis ( LC ) and fasting often induces starvation which is a vitally important outcome .'],
 'sickness': ['Musculoskeletal injuries and attrition incurred during basic military training are a significant socioeconomic burden across many Defence Forces.',
  'Motion sickness occurs worldwide in healthy individuals regardless of age, ethnicity, or gender',
  'Decompression sickness affecting the nervous system is still a serious problem in diving , but the mechanisms involved are in dispute .',
  'Space motion sickness ( SMS ) remains a troublesome problem during spaceflight .',
  'With over 750 service members living with amputations from recent combat , PLP will continue to be a troubling problem that requires effective interventions .',
  'Severe seasickness could pose a serious problem in diving , and anti-seasickness medication should therefore be prescribed for the seasickness-susceptible diver .',
  "ACL insufficiency remains a serious problem , with implications for a soldier 's fitness and career .",
  'Since bone and joint injuries rank high among the war injuries with a share of over 70 % including more than 30 % of fractures , they pose not only a serious medical and surgical but also a major public health problem .',
  'Our present understanding of G protection suggests that the elimination of LOC as a serious problem for USAF high-performance aircraft operations must include the supination of aircrew to a minimum seat back angle of 60 degrees to 65 degrees .',
  'High-acceleration loss of consciousness is a serious problem for military pilots .',
  'Motion sickness is a serious issue for many individuals , but the problem is particularly important among military personnel who may regularly experience unusual or extreme motion profiles as a part of their duties .',
  'Overtraining is a serious problem in sports , assessed by comprehensive multi-index evaluation , but so far there is still no sensitive , specific monitoring indicator or simple evaluation method to evaluate it .',
  'Musculoskeletal overuse injuries are a serious problem in the military , particularly in basic combat training , resulting in hundreds of millions of dollars lost because of limited duty days , medical treatment , and high rates of reinjury .',
  "Overtraining syndrome is a serious problem marked by decreased performance , increased fatigue , persistent muscle soreness , mood disturbances , and feeling ' burnt out ' or ' stale . ' The diagnosis of overtraining is usually complicated , there are no exact diagnostic criteria , and physicians must rule out other diseases before the diagnosis can be made .",
  'Neck and back pain in fighter pilots remains a serious occupational problem .',
  'Overuse injury including stress fracture is a serious problem for athletes .',
  'Fear of flying ( FOF ) can be a serious problem for individuals who develop this condition and for military and civilian organizations that operate aircraft .'],
 'military': ['Musculoskeletal injuries and attrition incurred during basic military training are a significant socioeconomic burden across many Defence Forces.',
  'Motion sickness occurs worldwide in healthy individuals regardless of age, ethnicity, or gender',
  'Decompression sickness affecting the nervous system is still a serious problem in diving , but the mechanisms involved are in dispute .',
  'Space motion sickness ( SMS ) remains a troublesome problem during spaceflight .',
  'With over 750 service members living with amputations from recent combat , PLP will continue to be a troubling problem that requires effective interventions .',
  'Severe seasickness could pose a serious problem in diving , and anti-seasickness medication should therefore be prescribed for the seasickness-susceptible diver .',
  "ACL insufficiency remains a serious problem , with implications for a soldier 's fitness and career .",
  'Since bone and joint injuries rank high among the war injuries with a share of over 70 % including more than 30 % of fractures , they pose not only a serious medical and surgical but also a major public health problem .',
  'Our present understanding of G protection suggests that the elimination of LOC as a serious problem for USAF high-performance aircraft operations must include the supination of aircrew to a minimum seat back angle of 60 degrees to 65 degrees .',
  'High-acceleration loss of consciousness is a serious problem for military pilots .',
  'Motion sickness is a serious issue for many individuals , but the problem is particularly important among military personnel who may regularly experience unusual or extreme motion profiles as a part of their duties .',
  'Overtraining is a serious problem in sports , assessed by comprehensive multi-index evaluation , but so far there is still no sensitive , specific monitoring indicator or simple evaluation method to evaluate it .',
  'Musculoskeletal overuse injuries are a serious problem in the military , particularly in basic combat training , resulting in hundreds of millions of dollars lost because of limited duty days , medical treatment , and high rates of reinjury .',
  "Overtraining syndrome is a serious problem marked by decreased performance , increased fatigue , persistent muscle soreness , mood disturbances , and feeling ' burnt out ' or ' stale . ' The diagnosis of overtraining is usually complicated , there are no exact diagnostic criteria , and physicians must rule out other diseases before the diagnosis can be made .",
  'Neck and back pain in fighter pilots remains a serious occupational problem .',
  'Overuse injury including stress fracture is a serious problem for athletes .',
  'Fear of flying ( FOF ) can be a serious problem for individuals who develop this condition and for military and civilian organizations that operate aircraft .'],
 'overtraining': ['Musculoskeletal injuries and attrition incurred during basic military training are a significant socioeconomic burden across many Defence Forces.',
  'Motion sickness occurs worldwide in healthy individuals regardless of age, ethnicity, or gender',
  'Decompression sickness affecting the nervous system is still a serious problem in diving , but the mechanisms involved are in dispute .',
  'Space motion sickness ( SMS ) remains a troublesome problem during spaceflight .',
  'With over 750 service members living with amputations from recent combat , PLP will continue to be a troubling problem that requires effective interventions .',
  'Severe seasickness could pose a serious problem in diving , and anti-seasickness medication should therefore be prescribed for the seasickness-susceptible diver .',
  "ACL insufficiency remains a serious problem , with implications for a soldier 's fitness and career .",
  'Since bone and joint injuries rank high among the war injuries with a share of over 70 % including more than 30 % of fractures , they pose not only a serious medical and surgical but also a major public health problem .',
  'Our present understanding of G protection suggests that the elimination of LOC as a serious problem for USAF high-performance aircraft operations must include the supination of aircrew to a minimum seat back angle of 60 degrees to 65 degrees .',
  'High-acceleration loss of consciousness is a serious problem for military pilots .',
  'Motion sickness is a serious issue for many individuals , but the problem is particularly important among military personnel who may regularly experience unusual or extreme motion profiles as a part of their duties .',
  'Overtraining is a serious problem in sports , assessed by comprehensive multi-index evaluation , but so far there is still no sensitive , specific monitoring indicator or simple evaluation method to evaluate it .',
  'Musculoskeletal overuse injuries are a serious problem in the military , particularly in basic combat training , resulting in hundreds of millions of dollars lost because of limited duty days , medical treatment , and high rates of reinjury .',
  "Overtraining syndrome is a serious problem marked by decreased performance , increased fatigue , persistent muscle soreness , mood disturbances , and feeling ' burnt out ' or ' stale . ' The diagnosis of overtraining is usually complicated , there are no exact diagnostic criteria , and physicians must rule out other diseases before the diagnosis can be made .",
  'Neck and back pain in fighter pilots remains a serious occupational problem .',
  'Overuse injury including stress fracture is a serious problem for athletes .',
  'Fear of flying ( FOF ) can be a serious problem for individuals who develop this condition and for military and civilian organizations that operate aircraft .'],
 'epidural': ['Continuous bilateral thoracic paravertebral blockade has been used for analgesia after cardiac surgery, but its efficacy has never been formally tested.',
  'Use of i.v. paracetamol for postoperative pain is well documented, but it is unclear if it can reduce the consumption of opioids during patient-controlled epidural analgesia (PCEA) in labouring parturients.',
  'Labor epidural failure : a serious concern !',
  'Chronic post-surgical pain ( CPSP ) is a serious problem .',
  'Chronic post-thoracotomy pain ( CPP ) is a vexing clinical problem whose management has received scant attention .',
  'Postoperative pain was a serious problem and thoracic epidural provided satisfactory analgesia .',
  'Postamputation pain ( PAP ) is a serious problem , and thus far , there is no perfect treatment strategy .',
  'In the context of the much-heralded advantages of laparoscopic surgery , it can be easy to overlook postlaparoscopy pain as a serious problem , yet as many as 80 % of patients will require opioid analgesia .',
  'However , several surveys in the last few years demonstrated that postoperative pain in children is still a serious problem , mainly because opioids are avoided .',
  'Postoperative persistent chronic pain ( POCP ) is a serious health problem , disabling , undermining the quality of life of affected patients .',
  'Pain management after arthroplasties has become a serious problem .',
  'Post thoracotomy ipsilateral shoulder pain ( PTISP ) is a distressing and highly prevalent problem after thoracic surgery and has not received much attention despite the incidence as high as 85 % .',
  'Nine patients complained of mild memory impairment postoperatively and one had a severe amnestic problem .',
  'A distressing problem of persistent postoperative frontal pain is discussed in detail .',
  'Postoperative pain still poses a serious problem for 80 % of patients undergoing surgery .',
  'Post-dural puncture headache ( PDPHA ) has been a vexing problem for patients undergoing dural puncture for spinal anaesthesia , as a complication of epidural anaesthesia , and after diagnostic lumbar puncture since Bier reported the first case in 1898 .',
  'Post-dural puncture headache ( PDPH ) is a vexing problem of the patients following spinal anesthesia or a complication relative to inadvertent dural puncture in epidural anesthesia .',
  'Neurological injuries after epidural/spinal analgesia are a serious but uncommon problem .',
  'Post thoracotomy chronic pain is a severe problem that affects the majority of patients and decreases the quality of life .',
  'However , the intense intraoperative pain remains a serious problem .',
  'Postoperative pain is a serious problem , requiring an appropriate response from the medical doctor .',
  'Postoperative persistent chronic pain ( POCP ) is a serious health problem , disabling , undermining the quality of life of affected patients .'],
 'analgesia': ['Continuous bilateral thoracic paravertebral blockade has been used for analgesia after cardiac surgery, but its efficacy has never been formally tested.',
  'Use of i.v. paracetamol for postoperative pain is well documented, but it is unclear if it can reduce the consumption of opioids during patient-controlled epidural analgesia (PCEA) in labouring parturients.',
  'Labor epidural failure : a serious concern !',
  'Chronic post-surgical pain ( CPSP ) is a serious problem .',
  'Chronic post-thoracotomy pain ( CPP ) is a vexing clinical problem whose management has received scant attention .',
  'Postoperative pain was a serious problem and thoracic epidural provided satisfactory analgesia .',
  'Postamputation pain ( PAP ) is a serious problem , and thus far , there is no perfect treatment strategy .',
  'In the context of the much-heralded advantages of laparoscopic surgery , it can be easy to overlook postlaparoscopy pain as a serious problem , yet as many as 80 % of patients will require opioid analgesia .',
  'However , several surveys in the last few years demonstrated that postoperative pain in children is still a serious problem , mainly because opioids are avoided .',
  'Postoperative persistent chronic pain ( POCP ) is a serious health problem , disabling , undermining the quality of life of affected patients .',
  'Pain management after arthroplasties has become a serious problem .',
  'Post thoracotomy ipsilateral shoulder pain ( PTISP ) is a distressing and highly prevalent problem after thoracic surgery and has not received much attention despite the incidence as high as 85 % .',
  'Nine patients complained of mild memory impairment postoperatively and one had a severe amnestic problem .',
  'A distressing problem of persistent postoperative frontal pain is discussed in detail .',
  'Postoperative pain still poses a serious problem for 80 % of patients undergoing surgery .',
  'Post-dural puncture headache ( PDPHA ) has been a vexing problem for patients undergoing dural puncture for spinal anaesthesia , as a complication of epidural anaesthesia , and after diagnostic lumbar puncture since Bier reported the first case in 1898 .',
  'Post-dural puncture headache ( PDPH ) is a vexing problem of the patients following spinal anesthesia or a complication relative to inadvertent dural puncture in epidural anesthesia .',
  'Neurological injuries after epidural/spinal analgesia are a serious but uncommon problem .',
  'Post thoracotomy chronic pain is a severe problem that affects the majority of patients and decreases the quality of life .',
  'However , the intense intraoperative pain remains a serious problem .',
  'Postoperative pain is a serious problem , requiring an appropriate response from the medical doctor .',
  'Postoperative persistent chronic pain ( POCP ) is a serious health problem , disabling , undermining the quality of life of affected patients .'],
 'thoracotomy': ['Continuous bilateral thoracic paravertebral blockade has been used for analgesia after cardiac surgery, but its efficacy has never been formally tested.',
  'Use of i.v. paracetamol for postoperative pain is well documented, but it is unclear if it can reduce the consumption of opioids during patient-controlled epidural analgesia (PCEA) in labouring parturients.',
  'Labor epidural failure : a serious concern !',
  'Chronic post-surgical pain ( CPSP ) is a serious problem .',
  'Chronic post-thoracotomy pain ( CPP ) is a vexing clinical problem whose management has received scant attention .',
  'Postoperative pain was a serious problem and thoracic epidural provided satisfactory analgesia .',
  'Postamputation pain ( PAP ) is a serious problem , and thus far , there is no perfect treatment strategy .',
  'In the context of the much-heralded advantages of laparoscopic surgery , it can be easy to overlook postlaparoscopy pain as a serious problem , yet as many as 80 % of patients will require opioid analgesia .',
  'However , several surveys in the last few years demonstrated that postoperative pain in children is still a serious problem , mainly because opioids are avoided .',
  'Postoperative persistent chronic pain ( POCP ) is a serious health problem , disabling , undermining the quality of life of affected patients .',
  'Pain management after arthroplasties has become a serious problem .',
  'Post thoracotomy ipsilateral shoulder pain ( PTISP ) is a distressing and highly prevalent problem after thoracic surgery and has not received much attention despite the incidence as high as 85 % .',
  'Nine patients complained of mild memory impairment postoperatively and one had a severe amnestic problem .',
  'A distressing problem of persistent postoperative frontal pain is discussed in detail .',
  'Postoperative pain still poses a serious problem for 80 % of patients undergoing surgery .',
  'Post-dural puncture headache ( PDPHA ) has been a vexing problem for patients undergoing dural puncture for spinal anaesthesia , as a complication of epidural anaesthesia , and after diagnostic lumbar puncture since Bier reported the first case in 1898 .',
  'Post-dural puncture headache ( PDPH ) is a vexing problem of the patients following spinal anesthesia or a complication relative to inadvertent dural puncture in epidural anesthesia .',
  'Neurological injuries after epidural/spinal analgesia are a serious but uncommon problem .',
  'Post thoracotomy chronic pain is a severe problem that affects the majority of patients and decreases the quality of life .',
  'However , the intense intraoperative pain remains a serious problem .',
  'Postoperative pain is a serious problem , requiring an appropriate response from the medical doctor .',
  'Postoperative persistent chronic pain ( POCP ) is a serious health problem , disabling , undermining the quality of life of affected patients .'],
 'surfactant': ['The ability to monitor tissue oxygenation in neonates remains a challenge due to limited blood supply and the reliance on invasive procedures.',
  'With neonatal respiratory support using a heated humidifier , condensation following decreases in temperature within the unheated part of the inspiratory circuit represents a serious problem , due to the resulting drop in absolute humidity .',
  'Even though artificial surfactant is now available , respiratory distress syndrome still remains a serious problem in neonatology .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a serious neonatal problem which has a high mortality rate even with advanced modes of mechanical ventilation .',
  'Because of this , lung immaturity is a serious problem in premature infants .',
  'Despite advances in neonatal care in the past 50 years , bronchopulmonary dysplasia , with all its adverse short-term and long-term consequences , is still a serious problem in neonatal care .',
  'Neonatal respiratory failure ( RF ) is a serious clinical problem associated with high mortality .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Although ROP incidence did not increase during this review period , it remains a serious problem in high-risk premature infants in our Newborn Intensive Care Unit .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight ( VLBW ) infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Bronchopulmonary dysplasia ( BPD ) is a serious and common problem among very low birth weight infants , despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Ventilator-associated pneumonia is a serious problem which needs to be addressed for a better outcome of the ventilated babies .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a severe clinical problem among neonatal intensive care unit ( NICU ) patients .'],
 'antenatal': ['The ability to monitor tissue oxygenation in neonates remains a challenge due to limited blood supply and the reliance on invasive procedures.',
  'With neonatal respiratory support using a heated humidifier , condensation following decreases in temperature within the unheated part of the inspiratory circuit represents a serious problem , due to the resulting drop in absolute humidity .',
  'Even though artificial surfactant is now available , respiratory distress syndrome still remains a serious problem in neonatology .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a serious neonatal problem which has a high mortality rate even with advanced modes of mechanical ventilation .',
  'Because of this , lung immaturity is a serious problem in premature infants .',
  'Despite advances in neonatal care in the past 50 years , bronchopulmonary dysplasia , with all its adverse short-term and long-term consequences , is still a serious problem in neonatal care .',
  'Neonatal respiratory failure ( RF ) is a serious clinical problem associated with high mortality .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Although ROP incidence did not increase during this review period , it remains a serious problem in high-risk premature infants in our Newborn Intensive Care Unit .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight ( VLBW ) infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Bronchopulmonary dysplasia ( BPD ) is a serious and common problem among very low birth weight infants , despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Ventilator-associated pneumonia is a serious problem which needs to be addressed for a better outcome of the ventilated babies .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a severe clinical problem among neonatal intensive care unit ( NICU ) patients .'],
 'neonatal': ['The ability to monitor tissue oxygenation in neonates remains a challenge due to limited blood supply and the reliance on invasive procedures.',
  'Trying to differentiate serious bacterial infection (SBI) from a self-limiting illness in febrile infants seen in the pediatric emergency department (PED) is a significant challenge.',
  'Infectious disease and sepsis represent a serious problem for all , but especially in early life .',
  'A serious problem during intensive care and nursing of premature infants is the invasiveness of many examination methods .',
  'Severe local swelling has been regarded as a serious safety problem for the booster immunisations of diphtheria tetanus acellular pertussis combined ( DTaP ) vaccine and DT combined toxoids ( DT-td ) .',
  'With neonatal respiratory support using a heated humidifier , condensation following decreases in temperature within the unheated part of the inspiratory circuit represents a serious problem , due to the resulting drop in absolute humidity .',
  'Pertussis remains a serious problem in many countries .',
  'Even though artificial surfactant is now available , respiratory distress syndrome still remains a serious problem in neonatology .',
  'Nosocomial sepsis is a serious problem for neonates who are admitted for intensive care .',
  'Tetanus remains a serious problem in public health , particularly in developing countries , despite efficient prevention programs .',
  'Delayed diagnosis of congenital tuberculosis ( TB ) in the neonatal intensive care unit ( NICU ) is a serious problem in terms of infection control .',
  'Although neonatal tetanus in China has been eliminated since 2012 , non-neonatal tetanus remains a serious public health problem .',
  'With pertussis continuing to pose a serious threat to infants , and greatly affecting adolescents and adults , there remains a need to : ( a ) increase the awareness of physicians as to the growing pertussis problem , ( b ) standardize diagnostic techniques , and ( c ) implement various new vaccine strategies to enhance its control .',
  'These findings resemble those seen in necrotizing enterocolitis of premature babies , a serious intestinal problem in the neonate .',
  'Perinatal infections are the leading cause of severe congenital pathology , a serious worldwide medical and social problem that needs to be addressed .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a serious neonatal problem which has a high mortality rate even with advanced modes of mechanical ventilation .',
  'Because of this , lung immaturity is a serious problem in premature infants .',
  'Neonatal sepsis remains a serious problem in any neonatal intensive care unit ( NICU ) .',
  'Despite advances in neonatal care in the past 50 years , bronchopulmonary dysplasia , with all its adverse short-term and long-term consequences , is still a serious problem in neonatal care .',
  'Nosocomial sepsis is a serious problem for neonates who are admitted for intensive care .',
  'Neonatal respiratory failure ( RF ) is a serious clinical problem associated with high mortality .',
  'Pediatric disease is atypical in developed regions but remains a serious concern in resource-limited areas where infection occurs commonly at birth and through breast feeding .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Introduction In developing countries , sepsis and associated mortality rates in neonatal patients is a serious concern .',
  'However , most infections are asymptomatic , indicating that CMV infection in preterm infants within such a population is a serious problem infrequently .',
  'Gram-negative sepsis/septic shock in the human newborn continues to be a severe medical problem because of significant mortality and morbidity .',
  'Although ROP incidence did not increase during this review period , it remains a serious problem in high-risk premature infants in our Newborn Intensive Care Unit .',
  'Neonatal infection is a serious public health problem .',
  'Nosocomial infections are a serious problem among very low birth weight ( VLBW ) infants .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight ( VLBW ) infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Candidal infections are a serious problem in neonatal intensive care units , increasing morbidity and mortality in low birth weight infants in addition to escalating health-care costs .',
  'Bordetella pertussis infection is endemic and continues to be a serious problem among unvaccinated or incompletely vaccinated infants .',
  'Tetanus is an acute specific infection caused by obligate anaerobes , which is still a serious public health problem .',
  'Newborns with gastroschisis despite progress in prenatal diagnostics , neonatal intensive care and surgical methods remains a serious therapeutic problem requiring multidisciplinary care and long-standing hospital stay .',
  'VKDB , a preventable cause of life-threatening hemorrhage , is still a major health problem in Egyptian infants , where persistent diarrhea and misuse of antibiotics are prevalent , necessitate a booster dose of VK in those high risk infants .',
  'Once introduced , RV appears to become a troublesome problem of HA infections in neonatal care settings .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Pertussis ( whooping cough ) remains an epidemic disease responsible for infant and child morbidity and mortality , and is perceived as a serious public health problem .',
  'Advances in neonatal care have led to the increasing survival of smaller and sicker infants , but nosocomial infections continue to be a serious problem , associated with increased mortality rates , immediate and long-term morbidity , prolonged hospital stay , and increased cost of care .',
  'Background Nosocomial infections are a serious problem in the treatment of extremely low birth weight infants ( ELBW , < 1 \u2009',
  'Neonatal late-onset sepsis ( LOS ) is a serious problem in neonatal intensive care .',
  'Early diagnosis of neonatal septicemia is a vexing problem because of its non-specific clinical picture .',
  'Bronchopulmonary dysplasia ( BPD ) is a serious and common problem among very low birth weight infants , despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Ventilator-associated pneumonia is a serious problem which needs to be addressed for a better outcome of the ventilated babies .',
  'Tetanus represented a serious health problem in the Czech Republic until 1974 with a substantial number of deaths .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a severe clinical problem among neonatal intensive care unit ( NICU ) patients .',
  'Non-neonatal tetanus remains a serious public health problem , although neonatal tetanus has been eliminated in China since 2012 .',
  'Recurrent infection that can progress to life-threatening renal failure has remained as a serious global health concern in infants .',
  'Necrotizing enterocolitis ( NEC ) is a serious problem in nurseries for premature infants and neonatal intensive care units , with a high incidence of morbidity and mortality .',
  'Sepsis occurring in the first week of life can be a devastating neonatal problem .',
  'Gastrointestinal tract perforation in neonates is a serious problem associated with high morbidity and mortality .',
  'Selective primary health care : strategies for control of disease in the developing world . XXII . Tetanus : a preventable problem .',
  'Bacterial infection remains a serious problem in neonatal intensive care .',
  'Fungemia is a serious problem within neonatal intensive care units around the world .',
  'Notwithstanding its substantial decline over the last two decades , acquired tetanus is still a serious health problem in most developing countries .',
  'Infections represent a serious health problem in neonates .',
  'In Utah , the lack of pertussis immunization among young children is a serious problem : greater than 30 % of 1-year-old children were not adequately protected .',
  'Early onset sepsis ( EOS ) is a severe problem affecting very low birth weight ( VLBW ) infants and is associated with a threefold increased risk of mortality .',
  'Neonatal early-onset sepsis is a serious health concern for term and late preterm infants .',
  'Worldwide , pertussis remains a serious health concern , especially for infants , who bear the greatest disease burden .',
  'Health care-associated infection ( HCAI ) is a serious problem of neonatal intensive care units ( NICUs ) which is related to morbidity , mortality and increased cost of medical care .',
  'Invasiveness of examination and therapy methods is a serious problem for intensive care and nursing of premature infants .',
  'Gastro-intestinal tract ( GIT ) perforation in neonates is a serious problem associated with high mortality due to resulting sepsis .'],
 'infants': ['The ability to monitor tissue oxygenation in neonates remains a challenge due to limited blood supply and the reliance on invasive procedures.',
  'Trying to differentiate serious bacterial infection (SBI) from a self-limiting illness in febrile infants seen in the pediatric emergency department (PED) is a significant challenge.',
  'Preterm infants generally spend weeks in the neonatal intensive care unit where light intensity can fluctuate as well as be high, leading to physiological instability and increased motor activity in these infants.',
  'Infectious disease and sepsis represent a serious problem for all , but especially in early life .',
  'Kernicterus , a preventable injury to the brain from severe neonatal jaundice , has re-emerged in the United States as a public and societal health concern .',
  'Birth asphyxia is a serious clinical problem worldwide .',
  'Hypoxic-ischemic brain injury and hypoxic-ischemic encephalopathy ( HIE ) remain a serious problem for both preterm and term neonates with the spectrum of injury ranging from neuronal injury to encephalopathy and death .',
  'A serious problem during intensive care and nursing of premature infants is the invasiveness of many examination methods .',
  'With neonatal respiratory support using a heated humidifier , condensation following decreases in temperature within the unheated part of the inspiratory circuit represents a serious problem , due to the resulting drop in absolute humidity .',
  'Neonatal brain hypoxic-ischemic injury represents a serious health care and socio-economical problem since it is one of the most common causes of mortality and morbidity of newborns .',
  'Extrauterine growth restriction ( EUGR ) remains a serious problem among very low birth weight ( VLBW ) infants and is a marker of severe nutritional deficit during the first weeks of life .',
  'Postnatal growth restriction remains a serious problem in very low-birth-weight infants .',
  'Even though artificial surfactant is now available , respiratory distress syndrome still remains a serious problem in neonatology .',
  'Nosocomial sepsis is a serious problem for neonates who are admitted for intensive care .',
  'Periventricular-intraventricular hemorrhage is a serious problem in the premature infant , and is often associated with poor neurological outcome .',
  'Neonatal stroke , including perinatal arterial ischaemic stroke and cerebral sinovenous thrombosis , remains a serious problem in the neonate .',
  'The purpose of this article is to define autoerotic asphyxia and present the enigma as a preventable problem .',
  'Although it has been possible to reduce the percentage of premature infants suffering intraventricular hemorrhage , posthemorrhagic hydrocephalus remains a serious problem without a good treatment .',
  'Delayed diagnosis of congenital tuberculosis ( TB ) in the neonatal intensive care unit ( NICU ) is a serious problem in terms of infection control .',
  'Birth asphyxia is a serious problem worldwide , resulting in 1 million deaths and an equal number of neurologic sequelae annually .',
  'Although the percentage of preterm infants developing IVH has been greatly reduced in the last three decades , increased survival of these very immature infants has meant that large IVH with subsequent PHH is still a serious unsolved problem .',
  'These findings resemble those seen in necrotizing enterocolitis of premature babies , a serious intestinal problem in the neonate .',
  'Perinatal infections are the leading cause of severe congenital pathology , a serious worldwide medical and social problem that needs to be addressed .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a serious neonatal problem which has a high mortality rate even with advanced modes of mechanical ventilation .',
  'Low birth weight ( LBW ) infants with reduced nephron numbers have significantly increased risk for hypertension later in life , which is a devastating health problem .',
  'Because of this , lung immaturity is a serious problem in premature infants .',
  'Neonatal sepsis remains a serious problem in any neonatal intensive care unit ( NICU ) .',
  'Despite advances in neonatal care in the past 50 years , bronchopulmonary dysplasia , with all its adverse short-term and long-term consequences , is still a serious problem in neonatal care .',
  'Occurring in five of 1000 live-born infants globally and even more in developing countries , HIE is a serious problem that causes death in 25%-50 % of affected neonates and neurological disability to at least 25 % of survivors .',
  'Bleeding and thrombosis in critically ill infants and children is a vexing clinical problem .',
  'Acute bleeding of different genesis can be a severe , life-threatening problem in neonatology .',
  'Prenatal hypoxia induced by transient intrauterine ischemia is a serious clinical problem , and at present , effective treatments are lacking .',
  'Nosocomial sepsis is a serious problem for neonates who are admitted for intensive care .',
  'Neonatal respiratory failure ( RF ) is a serious clinical problem associated with high mortality .',
  'Although in recent years the percentage of preterm infants who suffer intraventricular haemorrhage ( IVH ) has reduced , posthaemorrhagic hydrocephalus ( PHH ) remains a serious problem with a high rate of cerebral palsy and no evidence-based treatment .',
  'Pediatric disease is atypical in developed regions but remains a serious concern in resource-limited areas where infection occurs commonly at birth and through breast feeding .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Birth asphyxia is a preventable problem and long term neurological sequelae almost untreatable .',
  'Introduction In developing countries , sepsis and associated mortality rates in neonatal patients is a serious concern .',
  'However , most infections are asymptomatic , indicating that CMV infection in preterm infants within such a population is a serious problem infrequently .',
  'Gram-negative sepsis/septic shock in the human newborn continues to be a severe medical problem because of significant mortality and morbidity .',
  'Although ROP incidence did not increase during this review period , it remains a serious problem in high-risk premature infants in our Newborn Intensive Care Unit .',
  'Neonatal infection is a serious public health problem .',
  'Nosocomial infections are a serious problem among very low birth weight ( VLBW ) infants .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight ( VLBW ) infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Candidal infections are a serious problem in neonatal intensive care units , increasing morbidity and mortality in low birth weight infants in addition to escalating health-care costs .',
  'Neonatal disorders related to perinatal asphyxia remain a serious clinical problem , which calls for sustained education of advanced neonatal resuscitation and improvement in the quality of perinatal-neonatal care .',
  'Thromboembolic events in preterm infants constitute a serious problem in neonatal intensive care .',
  'Birth asphyxia represents a serious problem worldwide , resulting in approximately 1 million deaths and an equal number of serious sequelae annually .',
  'Bleeding in the newborn is often a serious problem because of cardiovascular effects associated with a loss of blood and/or the damaging effects of bleeding on neonatal tissues , especially the brain .',
  'Thromboembolic disease in newborn infants is a serious problem .',
  'Newborns with gastroschisis despite progress in prenatal diagnostics , neonatal intensive care and surgical methods remains a serious therapeutic problem requiring multidisciplinary care and long-standing hospital stay .',
  'VKDB , a preventable cause of life-threatening hemorrhage , is still a major health problem in Egyptian infants , where persistent diarrhea and misuse of antibiotics are prevalent , necessitate a booster dose of VK in those high risk infants .',
  'Once introduced , RV appears to become a troublesome problem of HA infections in neonatal care settings .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Birth asphyxia represents a serious problem worldwide , resulting in 1 million deaths and an equal number of neurologic sequelae annually .',
  'Despite advances in neonatal care , hypoxic-ischemic brain injury is still a serious clinical problem , which is responsible for many cases of perinatal mortality , cerebral palsy , motor impairment and cognitive deficits .',
  'Hydrocephalus is a serious problem in sub-Saharan Africa , whose effects can be minimized by a better organization of the health system in hydrocephalus prevention , referral , and follow-up .',
  'Advances in neonatal care have led to the increasing survival of smaller and sicker infants , but nosocomial infections continue to be a serious problem , associated with increased mortality rates , immediate and long-term morbidity , prolonged hospital stay , and increased cost of care .',
  'Background Nosocomial infections are a serious problem in the treatment of extremely low birth weight infants ( ELBW , < 1 \u2009',
  'Amniotic fluid embolism : A catastrophic problem in need of a prepared team with a plan .',
  'Birth asphyxia is a serious clinical problem worldwide .',
  'Neonatal late-onset sepsis ( LOS ) is a serious problem in neonatal intensive care .',
  'Although the percentage of small preterm infants developing intraventricular haemorrhage ( IVH ) has been greatly reduced in the last three decades , increased survival of very immature infants has meant that large IVH with subsequent posthaemorrhagic ventricular dilatation is still a serious unsolved problem .',
  'Early diagnosis of neonatal septicemia is a vexing problem because of its non-specific clinical picture .',
  'Bronchopulmonary dysplasia ( BPD ) is a serious and common problem among very low birth weight infants , despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Ventilator-associated pneumonia is a serious problem which needs to be addressed for a better outcome of the ventilated babies .',
  'Perinatal asphyxia is a severe problem which causes serious problem in neonates in developing countries .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a severe clinical problem among neonatal intensive care unit ( NICU ) patients .',
  'Recurrent infection that can progress to life-threatening renal failure has remained as a serious global health concern in infants .',
  'Necrotizing enterocolitis ( NEC ) is a serious problem in nurseries for premature infants and neonatal intensive care units , with a high incidence of morbidity and mortality .',
  'Sepsis occurring in the first week of life can be a devastating neonatal problem .',
  'Gastrointestinal tract perforation in neonates is a serious problem associated with high morbidity and mortality .',
  'Bacterial infection remains a serious problem in neonatal intensive care .',
  'Fungemia is a serious problem within neonatal intensive care units around the world .',
  'Infections represent a serious health problem in neonates .',
  'Early onset sepsis ( EOS ) is a severe problem affecting very low birth weight ( VLBW ) infants and is associated with a threefold increased risk of mortality .',
  'Neonatal early-onset sepsis is a serious health concern for term and late preterm infants .',
  'CNCLUSIONS : This preliminary study concludes that the rate of Pacific SIDS increased in 1995 and remains a serious problem .',
  'Posthaemorrhagic ventricular dilation following intraventricular haemorrhage is a serious problem with high morbidity in preterm babies .',
  'Health care-associated infection ( HCAI ) is a serious problem of neonatal intensive care units ( NICUs ) which is related to morbidity , mortality and increased cost of medical care .',
  'Invasiveness of examination and therapy methods is a serious problem for intensive care and nursing of premature infants .',
  'Gastro-intestinal tract ( GIT ) perforation in neonates is a serious problem associated with high mortality due to resulting sepsis .',
  'His work has led to the acceptance of caffeine as a standard treatment of apnea in premature infants , and his current studies of ibuprofen as a possible treatment of cerebral intraventricular hemorrhage , a serious problem in some premature babies , have yielded promising results .',
  'Germinal matrix-intraventricular haemorrhage ( GMH-IVH ) remains a serious problem in the very and extremely preterm infant .'],
 'newborn': ['The ability to monitor tissue oxygenation in neonates remains a challenge due to limited blood supply and the reliance on invasive procedures.',
  'With neonatal respiratory support using a heated humidifier , condensation following decreases in temperature within the unheated part of the inspiratory circuit represents a serious problem , due to the resulting drop in absolute humidity .',
  'Even though artificial surfactant is now available , respiratory distress syndrome still remains a serious problem in neonatology .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a serious neonatal problem which has a high mortality rate even with advanced modes of mechanical ventilation .',
  'Because of this , lung immaturity is a serious problem in premature infants .',
  'Despite advances in neonatal care in the past 50 years , bronchopulmonary dysplasia , with all its adverse short-term and long-term consequences , is still a serious problem in neonatal care .',
  'Neonatal respiratory failure ( RF ) is a serious clinical problem associated with high mortality .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Although ROP incidence did not increase during this review period , it remains a serious problem in high-risk premature infants in our Newborn Intensive Care Unit .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight ( VLBW ) infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Bronchopulmonary dysplasia ( BPD ) is a serious and common problem among very low birth weight infants , despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Ventilator-associated pneumonia is a serious problem which needs to be addressed for a better outcome of the ventilated babies .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a severe clinical problem among neonatal intensive care unit ( NICU ) patients .'],
 'bronchopulmonary': ['The ability to monitor tissue oxygenation in neonates remains a challenge due to limited blood supply and the reliance on invasive procedures.',
  'With neonatal respiratory support using a heated humidifier , condensation following decreases in temperature within the unheated part of the inspiratory circuit represents a serious problem , due to the resulting drop in absolute humidity .',
  'Even though artificial surfactant is now available , respiratory distress syndrome still remains a serious problem in neonatology .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a serious neonatal problem which has a high mortality rate even with advanced modes of mechanical ventilation .',
  'Because of this , lung immaturity is a serious problem in premature infants .',
  'Despite advances in neonatal care in the past 50 years , bronchopulmonary dysplasia , with all its adverse short-term and long-term consequences , is still a serious problem in neonatal care .',
  'Neonatal respiratory failure ( RF ) is a serious clinical problem associated with high mortality .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Although ROP incidence did not increase during this review period , it remains a serious problem in high-risk premature infants in our Newborn Intensive Care Unit .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight ( VLBW ) infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Chronic lung disease ( CLD ) remains a serious and common problem among very low birth weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Bronchopulmonary dysplasia ( BPD ) is a serious and common problem among very low birth weight infants , despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome .',
  'Ventilator-associated pneumonia is a serious problem which needs to be addressed for a better outcome of the ventilated babies .',
  'Persistent pulmonary hypertension of the newborn ( PPHN ) is a severe clinical problem among neonatal intensive care unit ( NICU ) patients .'],
 'tbi': ['Latinas/os with traumatic brain injuries (TBIs) and their caregivers experience worse outcomes than others.',
  'Traumatic Brain Injury (TBI) is a major health problem for adults aged 50-65 years',
  'Civilian penetrating traumatic brain injury ( pTBI ) is a serious public health problem in the United States , but predictors of outcome remain largely understudied .',
  'Mild traumatic brain injury ( MTBI ) is a serious health problem that has been difficult to study because of the relative insensitivity of established anatomical imaging techniques for detecting the associated neural damage and dysfunction .',
  'Despite advances in medicine in head trauma management , traumatic brain injury ( TBI ) still remains a serious health concern , affecting people regardless of age .',
  'Traumatic brain injury ( TBI ) is a serious medical and social problem worldwide .',
  'Traumatic brain injury ( TBI ) is a serious public health problem .',
  'Despite intensive research and clinical trials with numerous therapeutic treatments , traumatic brain injury ( TBI ) is a serious public health problem in the United States .',
  'Traumatic brain injury ( TBI ) remains a serious health concern , and TBI is one of the leading causes of death and disability , especially among young adults .',
  'Traumatic brain injury ( TBI ) is a serious public health and medical problem worldwide .',
  'Traumatic brain injury ( TBI ) still remains a serious health problem and is called a " silent epidemic " .',
  'Traumatic brain injury ( TBI ) is a serious global health problem , many individuals live with TBI-related neurological dysfunction .',
  'Traumatic brain injury is a serious clinical problem connected with high mortality rate and long-term neurobehavioral and socioeconomic consequences .',
  'With the increased frequency of military operations , terror attacks , sports activities , and road mishaps , TBIs are increasingly becoming a serious public health concern .',
  'The incidence of brain injuries on mortality and morbidity constitutes a serious problem in front of the Health Administration .',
  "Traumatic brain injury ( TBI ) is a serious public health issue that challenges professionals to develop effective health promotion strategies to meet individual 's diverse and unique needs .",
  'Traumatic Brain Injury ( TBI ) has been considered as a serious public health problem .',
  'Mild traumatic brain injury ( mTBI ) is a serious health concern in the adolescent population .',
  'Traumatic brain injury ( TBI ) is a serious public health concern which strikes someone every 15 s on average in the US .',
  'Mild traumatic brain injury ( mTBI ) is a common complication of minor head injury and a serious problem in the Iraq war returnees .',
  'Traumatic brain injury ( TBI ) is a devastating public health problem that may result in hypopituitarism .',
  'Mild traumatic brain injury ( mTBI ) represents a serious public health concern .',
  'Traumatic brain injury ( TBI ) is a serious health problem in the world .',
  'Fall-related traumatic brain injuries ( TBIs ) are a serious health concern for adults over the age of 75 \xa0 years , yet there is limited knowledge on possible modifiable risk factors .',
  'Traumatic brain injury ( TBI ) is a severe public health problem that impacts more than four million individuals in the United States alone and is increasing in incidence on a global scale .',
  'Traumatic brain injury ( TBI ) is a serious public health concern , especially injuries from repetitive insults .',
  'Traumatic brain injury remains a serious public health problem , causing death and disability for millions .',
  'Traumatic brain injury ( TBI ) is a serious healthcare problem , and this report is a selective review of recent findings on the epidemiology , pathophysiology and neuropsychological impairments following TBI .',
  'Traumatic brain injury ( TBI ) , a major cause of morbidity and mortality , is a serious public health concern .',
  'Traumatic brain injury ( TBI ) is a devastating public health problem which may result in hypopituitarism .',
  'The increased risk of hemorrhage associated with anticoagulant therapy following traumatic brain injury creates a serious dilemma for medical management of older patients : Should anticoagulant therapy be resumed after traumatic brain injury , and if so , when ?',
  'The increased survival after a severe acquired brain injury ( sABI ) raise the problem of making most effective the treatments in Intensive Care Unit (ICU)/Neurointensive Care Unit ( NICU ) , also integrating rehabilitation care .',
  'Traumatic brain injury ( TBI ) is a debilitating health problem and one of the most common post-TBI symptoms is pain , which can contribute to psychological issues such as Post-traumatic stress disorder ( PTSD ) and depression .',
  'Traumatic brain injury ( TBI ) is a serious health care problem on both individual and public health levels .',
  'Traumatic brain injuries ( TBIs ) continue to be a devastating problem with limited treatment options .',
  'Traumatic brain injury ( TBI ) is a serious problem that affects millions of people in the United States alone .',
  'Traumatic brain injury ( TBI ) is a serious public health concern and a major cause of death and disability worldwide .',
  'Traumatic brain injury is a devastating public health problem , the eighth leading cause of death across the world .',
  'With nearly half a million children affected each year , TBI is a serious public health problem .',
  'Even if only a small proportion of children with mild TBI suffer negative outcomes , then mild TBI is a serious public health problem .',
  'Despite this increased focus on identifying biomarkers for outcome prognostication after a severe TBI , several challenges still exist in effectively modeling the significant heterogeneity observed in TBI-related pathology , as well as the biomarker-outcome relationships .',
  'Traumatic brain injury in the United States is a serious health problem : it is a significant factor in approximately half of all trauma-related deaths , and , leads to persistent , long-term neurologic dysfunction in survivors .',
  'Meningitis is a serious concern after traumatic brain injury ( TBI ) or neurosurgery .',
  'In the United States , traumatic brain injury ( TBI ) remains a serious health problem contributing to lifelong disability .',
  'Traumatic brain injury ( TBI ) is a serious public health problem , often with devastating consequences for patients and their families .',
  'Traumatic brain injury ( TBI ) is a serious health concern for civilians and military populations , and blast-induced TBI ( bTBI ) has become an increasing problem for military personnel over the past 10 years .',
  'Traumatic brain injury ( TBI ) is a serious problem that causes high morbidity and mortality around the world .',
  'Traumatic brain injury ( TBI ) is a serious public health problem .',
  'Traumatic brain injury ( TBI ) is a serious public health problem in the United States .',
  'Traumatic brain injury ( TBI ) is a serious public health problem as well as a leading cause of severe posttraumatic disability .',
  'Traumatic brain injury ( TBI ) is a serious global public health problem .',
  'Mild traumatic brain injury ( TBI ) is a serious public health concern affecting more than 1.7 million people in the United States annually .',
  'Traumatic brain injury ( TBI ) is a debilitating medical and emerging public health problem that is affecting people worldwide due to a multitude of factors including both domestic and war-related acts .',
  'Traumatic brain injury ( TBI ) is a serious public health problem accounting for 1.4 million emergency room visits by US citizens each year .',
  'Traumatic brain injury ( TBI ) is a serious public health problem in the United States , yet no treatment is currently available to improve outcome after TBI .',
  'Traumatic Brain Injury ( TBI ) is a serious global public health problem .',
  'Pediatric traumatic brain injury ( TBI ) represents a serious public health concern .',
  'Traumatic brain injury ( TBI ) is a serious public health problem in the United States .'],
 'traumatic': ['Latinas/os with traumatic brain injuries (TBIs) and their caregivers experience worse outcomes than others.',
  'Traumatic Brain Injury (TBI) is a major health problem for adults aged 50-65 years',
  'Civilian penetrating traumatic brain injury ( pTBI ) is a serious public health problem in the United States , but predictors of outcome remain largely understudied .',
  'Mild traumatic brain injury ( MTBI ) is a serious health problem that has been difficult to study because of the relative insensitivity of established anatomical imaging techniques for detecting the associated neural damage and dysfunction .',
  'Despite advances in medicine in head trauma management , traumatic brain injury ( TBI ) still remains a serious health concern , affecting people regardless of age .',
  'Traumatic brain injury ( TBI ) is a serious medical and social problem worldwide .',
  'Traumatic brain injury ( TBI ) is a serious public health problem .',
  'Despite intensive research and clinical trials with numerous therapeutic treatments , traumatic brain injury ( TBI ) is a serious public health problem in the United States .',
  'Traumatic brain injury ( TBI ) remains a serious health concern , and TBI is one of the leading causes of death and disability , especially among young adults .',
  'Traumatic brain injury ( TBI ) is a serious public health and medical problem worldwide .',
  'Traumatic brain injury ( TBI ) still remains a serious health problem and is called a " silent epidemic " .',
  'Traumatic brain injury ( TBI ) is a serious global health problem , many individuals live with TBI-related neurological dysfunction .',
  'Traumatic brain injury is a serious clinical problem connected with high mortality rate and long-term neurobehavioral and socioeconomic consequences .',
  'With the increased frequency of military operations , terror attacks , sports activities , and road mishaps , TBIs are increasingly becoming a serious public health concern .',
  'The incidence of brain injuries on mortality and morbidity constitutes a serious problem in front of the Health Administration .',
  "Traumatic brain injury ( TBI ) is a serious public health issue that challenges professionals to develop effective health promotion strategies to meet individual 's diverse and unique needs .",
  'Traumatic Brain Injury ( TBI ) has been considered as a serious public health problem .',
  'Mild traumatic brain injury ( mTBI ) is a serious health concern in the adolescent population .',
  'Traumatic brain injury ( TBI ) is a serious public health concern which strikes someone every 15 s on average in the US .',
  'Mild traumatic brain injury ( mTBI ) is a common complication of minor head injury and a serious problem in the Iraq war returnees .',
  'Traumatic brain injury ( TBI ) is a devastating public health problem that may result in hypopituitarism .',
  'Mild traumatic brain injury ( mTBI ) represents a serious public health concern .',
  'Traumatic brain injury ( TBI ) is a serious health problem in the world .',
  'Fall-related traumatic brain injuries ( TBIs ) are a serious health concern for adults over the age of 75 \xa0 years , yet there is limited knowledge on possible modifiable risk factors .',
  'Traumatic brain injury ( TBI ) is a severe public health problem that impacts more than four million individuals in the United States alone and is increasing in incidence on a global scale .',
  'Traumatic brain injury ( TBI ) is a serious public health concern , especially injuries from repetitive insults .',
  'Traumatic brain injury remains a serious public health problem , causing death and disability for millions .',
  'Traumatic brain injury ( TBI ) is a serious healthcare problem , and this report is a selective review of recent findings on the epidemiology , pathophysiology and neuropsychological impairments following TBI .',
  'Traumatic brain injury ( TBI ) , a major cause of morbidity and mortality , is a serious public health concern .',
  'Traumatic brain injury ( TBI ) is a devastating public health problem which may result in hypopituitarism .',
  'The increased risk of hemorrhage associated with anticoagulant therapy following traumatic brain injury creates a serious dilemma for medical management of older patients : Should anticoagulant therapy be resumed after traumatic brain injury , and if so , when ?',
  'The increased survival after a severe acquired brain injury ( sABI ) raise the problem of making most effective the treatments in Intensive Care Unit (ICU)/Neurointensive Care Unit ( NICU ) , also integrating rehabilitation care .',
  'Traumatic brain injury ( TBI ) is a debilitating health problem and one of the most common post-TBI symptoms is pain , which can contribute to psychological issues such as Post-traumatic stress disorder ( PTSD ) and depression .',
  'Traumatic brain injury ( TBI ) is a serious health care problem on both individual and public health levels .',
  'Traumatic brain injuries ( TBIs ) continue to be a devastating problem with limited treatment options .',
  'Traumatic brain injury ( TBI ) is a serious problem that affects millions of people in the United States alone .',
  'Traumatic brain injury ( TBI ) is a serious public health concern and a major cause of death and disability worldwide .',
  'Traumatic brain injury is a devastating public health problem , the eighth leading cause of death across the world .',
  'With nearly half a million children affected each year , TBI is a serious public health problem .',
  'Even if only a small proportion of children with mild TBI suffer negative outcomes , then mild TBI is a serious public health problem .',
  'Despite this increased focus on identifying biomarkers for outcome prognostication after a severe TBI , several challenges still exist in effectively modeling the significant heterogeneity observed in TBI-related pathology , as well as the biomarker-outcome relationships .',
  'Traumatic brain injury in the United States is a serious health problem : it is a significant factor in approximately half of all trauma-related deaths , and , leads to persistent , long-term neurologic dysfunction in survivors .',
  'Meningitis is a serious concern after traumatic brain injury ( TBI ) or neurosurgery .',
  'In the United States , traumatic brain injury ( TBI ) remains a serious health problem contributing to lifelong disability .',
  'Traumatic brain injury ( TBI ) is a serious public health problem , often with devastating consequences for patients and their families .',
  'Traumatic brain injury ( TBI ) is a serious health concern for civilians and military populations , and blast-induced TBI ( bTBI ) has become an increasing problem for military personnel over the past 10 years .',
  'Traumatic brain injury ( TBI ) is a serious problem that causes high morbidity and mortality around the world .',
  'Traumatic brain injury ( TBI ) is a serious public health problem .',
  'Traumatic brain injury ( TBI ) is a serious public health problem in the United States .',
  'Traumatic brain injury ( TBI ) is a serious public health problem as well as a leading cause of severe posttraumatic disability .',
  'Traumatic brain injury ( TBI ) is a serious global public health problem .',
  'Mild traumatic brain injury ( TBI ) is a serious public health concern affecting more than 1.7 million people in the United States annually .',
  'Traumatic brain injury ( TBI ) is a debilitating medical and emerging public health problem that is affecting people worldwide due to a multitude of factors including both domestic and war-related acts .',
  'Traumatic brain injury ( TBI ) is a serious public health problem accounting for 1.4 million emergency room visits by US citizens each year .',
  'Traumatic brain injury ( TBI ) is a serious public health problem in the United States , yet no treatment is currently available to improve outcome after TBI .',
  'Traumatic Brain Injury ( TBI ) is a serious global public health problem .',
  'Pediatric traumatic brain injury ( TBI ) represents a serious public health concern .',
  'Traumatic brain injury ( TBI ) is a serious public health problem in the United States .'],
 'brain': ['Latinas/os with traumatic brain injuries (TBIs) and their caregivers experience worse outcomes than others.',
  'Traumatic Brain Injury (TBI) is a major health problem for adults aged 50-65 years',
  'A drawback of pre-existing in vitro models is that since susceptibility to ischemic injury is age-dependent ; neuroprotection is being studied in neurons that have intrinsic resistance to oxygen-glucose deprivation ( OGD ) .',
  'Limited coverage of the brain in the z-axis has been a drawback of perfusion CT .',
  'Civilian penetrating traumatic brain injury ( pTBI ) is a serious public health problem in the United States , but predictors of outcome remain largely understudied .',
  'Reperfusion injury is a serious problem in ischemic stroke therapy , which leads to neuronal damage and intracranial hemorrhage ( ICH ) .',
  'Mild traumatic brain injury ( MTBI ) is a serious health problem that has been difficult to study because of the relative insensitivity of established anatomical imaging techniques for detecting the associated neural damage and dysfunction .',
  'Despite advances in medicine in head trauma management , traumatic brain injury ( TBI ) still remains a serious health concern , affecting people regardless of age .',
  'Traumatic brain injury ( TBI ) is a serious medical and social problem worldwide .',
  'Traumatic brain injury ( TBI ) is a serious public health problem .',
  'Despite intensive research and clinical trials with numerous therapeutic treatments , traumatic brain injury ( TBI ) is a serious public health problem in the United States .',
  'Traumatic brain injury ( TBI ) remains a serious health concern , and TBI is one of the leading causes of death and disability , especially among young adults .',
  'Traumatic brain injury ( TBI ) is a serious public health and medical problem worldwide .',
  'Traumatic brain injury ( TBI ) still remains a serious health problem and is called a " silent epidemic " .',
  'Traumatic brain injury ( TBI ) is a serious global health problem , many individuals live with TBI-related neurological dysfunction .',
  'Traumatic brain injury is a serious clinical problem connected with high mortality rate and long-term neurobehavioral and socioeconomic consequences .',
  'With the increased frequency of military operations , terror attacks , sports activities , and road mishaps , TBIs are increasingly becoming a serious public health concern .',
  'The incidence of brain injuries on mortality and morbidity constitutes a serious problem in front of the Health Administration .',
  "Traumatic brain injury ( TBI ) is a serious public health issue that challenges professionals to develop effective health promotion strategies to meet individual 's diverse and unique needs .",
  'Traumatic Brain Injury ( TBI ) has been considered as a serious public health problem .',
  'Mild traumatic brain injury ( mTBI ) is a serious health concern in the adolescent population .',
  'Unfortunately , the cerebral re-perfusion syndrome is still a serious and not completely solved problem .',
  'Traumatic brain injury ( TBI ) is a serious public health concern which strikes someone every 15 s on average in the US .',
  'Mild traumatic brain injury ( mTBI ) is a common complication of minor head injury and a serious problem in the Iraq war returnees .',
  'Traumatic brain injury ( TBI ) is a devastating public health problem that may result in hypopituitarism .',
  'Mild traumatic brain injury ( mTBI ) represents a serious public health concern .',
  'Traumatic brain injury ( TBI ) is a serious health problem in the world .',
  'Fall-related traumatic brain injuries ( TBIs ) are a serious health concern for adults over the age of 75 \xa0 years , yet there is limited knowledge on possible modifiable risk factors .',
  'Traumatic brain injury ( TBI ) is a severe public health problem that impacts more than four million individuals in the United States alone and is increasing in incidence on a global scale .',
  'Traumatic brain injury ( TBI ) is a serious public health concern , especially injuries from repetitive insults .',
  'Traumatic brain injury remains a serious public health problem , causing death and disability for millions .',
  'Traumatic brain injury ( TBI ) is a serious healthcare problem , and this report is a selective review of recent findings on the epidemiology , pathophysiology and neuropsychological impairments following TBI .',
  'Traumatic brain injury ( TBI ) , a major cause of morbidity and mortality , is a serious public health concern .',
  'Traumatic brain injury ( TBI ) is a devastating public health problem which may result in hypopituitarism .',
  'The increased risk of hemorrhage associated with anticoagulant therapy following traumatic brain injury creates a serious dilemma for medical management of older patients : Should anticoagulant therapy be resumed after traumatic brain injury , and if so , when ?',
  'Because it is a severe and complex problem , several studies have been done aiming to elucidate the mechanisms of the ischemic phenomenon and aiming to abolish or to diminish its effects , using drugs that protect the neurons from ischaemia-induced damage .',
  'The increased survival after a severe acquired brain injury ( sABI ) raise the problem of making most effective the treatments in Intensive Care Unit (ICU)/Neurointensive Care Unit ( NICU ) , also integrating rehabilitation care .',
  'Traumatic brain injury ( TBI ) is a debilitating health problem and one of the most common post-TBI symptoms is pain , which can contribute to psychological issues such as Post-traumatic stress disorder ( PTSD ) and depression .',
  'Traumatic brain injury ( TBI ) is a serious health care problem on both individual and public health levels .',
  'Traumatic brain injuries ( TBIs ) continue to be a devastating problem with limited treatment options .',
  'Cell therapy is a potential therapeutic method for cerebral ischemia , which remains a serious problem .',
  'Traumatic brain injury ( TBI ) is a serious problem that affects millions of people in the United States alone .',
  'Traumatic brain injury ( TBI ) is a serious public health concern and a major cause of death and disability worldwide .',
  'Cerebral ischemia/reperfusion injury is a severe problem in patients with brain ischemia .',
  'Traumatic brain injury is a devastating public health problem , the eighth leading cause of death across the world .',
  'BACKGROUND Cerebral ischemia-reperfusion injury ( CIRI ) remains a serious health problem .',
  'With nearly half a million children affected each year , TBI is a serious public health problem .',
  'Even if only a small proportion of children with mild TBI suffer negative outcomes , then mild TBI is a serious public health problem .',
  'Despite this increased focus on identifying biomarkers for outcome prognostication after a severe TBI , several challenges still exist in effectively modeling the significant heterogeneity observed in TBI-related pathology , as well as the biomarker-outcome relationships .',
  'Traumatic brain injury in the United States is a serious health problem : it is a significant factor in approximately half of all trauma-related deaths , and , leads to persistent , long-term neurologic dysfunction in survivors .',
  'Meningitis is a serious concern after traumatic brain injury ( TBI ) or neurosurgery .',
  'In the United States , traumatic brain injury ( TBI ) remains a serious health problem contributing to lifelong disability .',
  "Vascular insufficiency of the child 's brain is a serious problem because perfusion can be disturbed sufficiently enough to cause permanent brain changes with extensive neurological deficit resulting in some .",
  'Traumatic brain injury ( TBI ) is a serious public health problem , often with devastating consequences for patients and their families .',
  'Traumatic brain injury ( TBI ) is a serious health concern for civilians and military populations , and blast-induced TBI ( bTBI ) has become an increasing problem for military personnel over the past 10 years .',
  'Traumatic brain injury ( TBI ) is a serious problem that causes high morbidity and mortality around the world .',
  'Traumatic brain injury ( TBI ) is a serious public health problem .',
  'Traumatic brain injury ( TBI ) is a serious public health problem in the United States .',
  'Cerebral ischemia-reperfusion ( IR ) has attracted wide attention as a serious clinical problem .',
  'Traumatic brain injury ( TBI ) is a serious public health problem as well as a leading cause of severe posttraumatic disability .',
  "Cerebral ischemia-reperfusion ( I/R ) injury is also a serious problem for patients ' outcomes .",
  'Traumatic brain injury ( TBI ) is a serious global public health problem .',
  'Mild traumatic brain injury ( TBI ) is a serious public health concern affecting more than 1.7 million people in the United States annually .',
  'Traumatic brain injury ( TBI ) is a debilitating medical and emerging public health problem that is affecting people worldwide due to a multitude of factors including both domestic and war-related acts .',
  'Traumatic brain injury ( TBI ) is a serious public health problem accounting for 1.4 million emergency room visits by US citizens each year .',
  'Traumatic brain injury ( TBI ) is a serious public health problem in the United States , yet no treatment is currently available to improve outcome after TBI .',
  'In particularly , hippocampal injury after ischemia-reperfusion is a serious problem as it contributes to vascular dementia .',
  'Ischemia is a serious problem in clinical medicine , and effective methods are needed to detect ischemia before the injury becomes irreversible .',
  'Unfortunately , cerebral re-perfusion syndrome is a serious unresolved problem .',
  'Traumatic Brain Injury ( TBI ) is a serious global public health problem .',
  'Pediatric traumatic brain injury ( TBI ) represents a serious public health concern .',
  'Traumatic brain injury ( TBI ) is a serious public health problem in the United States .',
  'Inflammatory response that occur post-ischemia is a serious problem in the treatment of ischemic brain disease .'],
 'radiation': ['Survivors of childhood with haematopoietic stem cell transplantation and total body irradiation (HSCT/TBI) have an increased cardiometabolic risk without overt obesity.',
  'The main problem with these hypotheses is that recently performed assays show no cell loss during the first days after irradiation , while saliva flow is dramatically diminished .',
  'The problem with the current ICRP system of radiation protection , particularly for regulators , is that it fails to differentiate between the application of justification and optimisation to people in the circumstances of medical care or as part of a workforce , compared with their application to members of the general public in an environmental setting ; plus the fact that it also fails to address the issue of potential impacts on the rest of the environment in any meaningful way .',
  'An interesting problem associated with studying the effects of low doses of high atomic number and energy ( HZE ) particles , as found in space , is that not all cells will necessarily be similarly traversed during exposure , a scenario that greatly complicates the measurement of end points that require time to develop , gene-locus mutation being a perfect example .',
  'The central problem with such data is that the cell-killing component of radiation damage may mask the effects associated with repair of precancerous lesions .',
  'A major problem with risk estimation is that data are available only for substantial doses and must be extrapolated down to the low-dose region of interest in radiation protection .',
  'A major drawback of MDCT is the use of ionising radiation with the risk of inducing secondary cancer .',
  'Yet , the combination of IF-RT and IMRT leads to a significantly better sparing of normal tissues and higher total doses whereas the potential therapeutic drawback of decreased incidental irradiation of elective lymph nodes is moderate .',
  'Ionizing radiation exposure is a recognized drawback of computed tomography ( CT ) , the primary imaging technique .',
  'A common drawback of semiconductor dosimeters with effective atomic numbers higher than soft tissues is that their responses depend on the presence of low energy photons for which the photoelectric cross section varies strongly with atomic number , which may affect the accuracy of dosimetric measurements .',
  'High radiation doses remain a drawback of current triple-rule-out computed tomography ( CT ) protocols .',
  'Meanwhile , a major drawback of PCT imaging is the high radiation dose due to its dynamic scan protocol .',
  'A major drawback of radiotherapy is the accelerated growth of the surviving tumor cells .',
  'An alternative radionuclide for brachytherapy is 170Tm ( Z=69 ) because it has three physical properties adequate for clinical practice : ( a ) 128.6 day half-life , ( b ) high specific activity , and ( c ) mean photon energy of 66.39 keV. The main drawback of this radionuclide is the low photon yield ( six photons per 100 electrons emitted ) .',
  'A major drawback of the new method is the relatively high radiation dose given to the patient .',
  'This dose rate is two to five times lower than those provided by existing reactor beams and can be viewed as a drawback of using 252Cf as a neutron source .',
  'Gut bacteria-associated sepsis is a serious concern in patients with gastrointestinal acute radiation syndrome ( GIARS ) .',
  'As people may be exposed to IR during cancer radiotherapy or as a result of a radiological/nuclear incident or act of terrorism , the danger of irradiation represents a serious public health problem .',
  'The toxic effects of radiation and cytostatics are a serious clinical problem connected with the physiologically or pathologically reduced antioxidant defense of normal tissues involved in the therapy .',
  'Currently , ionizing radiation ( IR ) plays a key role in the agricultural and medical industry , while accidental exposure resulting from leakage of radioactive sources or radiological terrorism is a serious concern .',
  'Radiation-induced dermatitis is a debilitating clinical problem in cancer patients undergoing cancer radiation therapy .',
  'Radiation therapy is widely used for the treatment of various types of cancers ; however , radiation-induced skin injury remains a serious concern .',
  'Recently , the late adverse events associated with radiotherapy ( especially extended field radiation therapy ) , such as cardiovascular disease and secondary cancers , become a serious problem for long-term lymphoma survivors .',
  'It is difficult to precisely locate the locking path , and intraoperative radiation exposure is also a serious problem .',
  'Radiation-induced enteritis is a serious clinical problem for which there is currently no recommended standard management .',
  'Radiation necrosis ( RN ) after intensive radiation therapy is a serious problem .',
  'The acute radiation morbidity may be a serious problem for the patient and may be decreased by pharmacological approaches .',
  'Skin injuries caused by burns or radiation remain a serious concern in terms of clinical therapy .',
  'Nevertheless , radiation exposure remains a serious safety concern .',
  'Radiotherapy‑induced lacrimal gland injury is a serious clinical problem currently lacking satisfactory therapeutic strategies .',
  'Damage to intestine is a serious problem after accidental radiation exposure .',
  'The late side effects of external beam irradiation in patients with retinoblastoma such as orbital bony growth retardation , are a serious problem in adolescence .',
  'Despite manifestation of rates of a fatal lung bleeding comparable to those seen with conventional radiotherapy for endobronchial tumors , the overall rate of G5 toxicity is of potential concern .',
  'Risks associated with exposure to ionizing radiation in patients undergoing electrophysiology procedures and interventional cardiac electrophysiologists performing these procedures are a serious concern .',
  'Excessive radiation exposure in pediatric computed tomography ( CT ) scanning has become a serious problem , and it is difficult to select scan parameters for the scanning of small patients such as children .',
  'Residential radon exposure is a serious public health concern , and as such appears in the recommendations of European Code Against Cancer .',
  'Radiation-induced skin injury remains a serious concern for radiation therapy .',
  'Radiation induced hemorrhage proctitis : a vexing problem .',
  'The Great East Japan Earthquake of 11 March 2011 , caused the Fukushima Daiichi Nuclear Power Plant Accident , which resulted in the release of a large amount of radioactive materials into the environment , and there is a serious concern about the radiation effects on the health of residents living in the affected areas .',
  'It is concluded that the heavy cosmic ray particles do not pose a serious problem for manned space flight .',
  'Of the late complications in Group B a serious problem was the development of severe radiation-induced fibrosis leading to microcystis and a cystectomy was indispensable in one of the patients .',
  'Particularly , when accurate patient-specific dose estimation is a serious concern in RAI treatment ( RAIT ) for nuclear medicine practitioners .',
  'The augmentation of radiation damage by cancer chemotherapeutic agents is a serious problem in a wide range of tissues , but a problem which can be dealt with by accurate knowledge as to the dose-effect factor and appropriate modification of the radiation treatment .',
  'X-ray imaging dose from computed tomography ( CT ) or cone beam CT ( CBCT ) scans has become a serious concern .',
  'The hazard of exposure to ionizing radiation is a serious public and military health concern that has justified substantial efforts to develop medically effective radiation countermeasure approaches , including radiation protectors , mitigators , and therapeutics .',
  'Radiation enteritis is a severe problem in patients receiving irradiation of the abdomen or pelvis in the course of cancer treatment .',
  'Radiation-induced skin injury remains a serious concern for cancer radiotherapy , radiation accidents and occupational exposure , and the damage mainly occurs due to apoptosis and reactive oxygen species ( ROS ) generation .',
  'Radiation-induced skin injury is a serious concern during radiotherapy .',
  'Gantry-couch collision is a serious concern for treatment planning of the linear accelerator ( linac ) based stereotactic radiosurgery ( SRS ) .',
  'The absence of appropriate radiological protection ( i.e. preventive measures like shortening working day , dosimetric measurements in the workplace ) is a serious problem in the Kletno adit .',
  'Despite the good general patient acceptance , high patient comfort , safety and precision in the needle placement , exposure to radiation in computed tomography (CT)-guided spinal interventions remains a serious concern , and is often used to argue against its use .',
  'Lung toxicity is a serious concern during total body irradiation ( TBI ) .',
  'This is of critical importance to space radiation , which remains a serious concern for long-term manned space exploration .',
  'Persistent disease after radiotherapy was a serious problem in advanced stages , especially in view of nonacceptance of salvage surgery by a significant proportion of patients .',
  'Namely , it tests whether survey respondents can recognize pictograms related to radiation safety according to their purpose , as their inability to do so poses a serious safety problem .',
  'Radiation-induced skin injury is a serious concern during radiotherapy and radiation accidents .',
  'Radiation exposure of aircrew is a serious concern which has been given special emphasis in the European Council directive 96/29/Euratom .',
  'These electrons cause a serious problem in the determination of a radiation weighting factor for (99m)Tc due to their extremely short range in tissue .',
  'Environmental contamination with radioactive materials caused by the Fukushima Dai-ichi Nuclear Power Plant ( NPP ) accident in 2011 raised a serious health concern among residents in Japan , and the demand for radiation experts who can handle the radiation-associated problems has increased .',
  'Recently , the influence of radiation on human body has been recognized as a serious problem .',
  'Accidental exposure to ionizing radiation is a serious concern to human life .',
  'Ionizing radiation from intraoperative fluoroscopy presents a serious occupational health and safety concern to orthopaedic surgeons .',
  'The lack of active participation in radiation protection is a serious problem in Radiologic Technology today .',
  'After the 2011 nuclear power plant accident at Fukushima , radiocesium contamination in food became a serious concern in Japan .',
  'Testers were more likely to view radon as a serious problem ( p = 0.00 ) , to consider radon testing efficacious ( p = 0.00 ) , and to consider themselves susceptible to exposure ( p = 0.00 ) .',
  'Radiation exposure is a serious concern with usage of serial multigated acquisition ( MUGA ) scans ( 7.8mSv/study ) for chemotherapy-related cardiotoxicity ( CRC ) screening .',
  'Radiation-induced reactive oxygen species ( ROS ) can damage DNA and most other biological macromolecules in skin and radiation-induced skin injury is a serious concern for radiation therapy .',
  'The effect of atomic bomb radiation exposure on the survivors and their children has been a worrisome problem since soon after the 1945 Hiroshima and Nagasaki bombings .',
  'Radiation damage to normal tissues is a serious concern in radiation therapy .',
  'The main benefit of CT-guided injections is the safe , fast and precise needle placement , but the radiation exposure remains a serious concern .',
  'The late health effects of low-dose rate radiation exposure are still a serious public concern in the Fukushima area even four years after the accident at Fukushima Daiichi Nuclear Power Plant ( FNPP ) .',
  'Serious late toxicities remain a serious concern demanding further improvement in radiotherapy technique and optimization of dose fractionation .',
  'We found a serious complication rate of 3 % for all patients treated , the major problem being radiation ileitis .',
  'Radiation-induced skin injury remains a serious concern during radiotherapy .',
  'Radiotherapy is one of the most important modalities in cancer treatment ; however , normal tissue damage is a serious concern .',
  'Radiation-induced gastric injury is a serious concern that may limit the duration and the delivered dose of radiation .',
  'Progressive radiation-induced cystitis can become a serious clinical problem the therapeutic solution of which is limited and almost invariably aggressive .',
  'Radiation-induced vascular injury can be a serious problem for cancer survivors .'],
 'radiotherapy': ['Survivors of childhood with haematopoietic stem cell transplantation and total body irradiation (HSCT/TBI) have an increased cardiometabolic risk without overt obesity.',
  'The main problem with these hypotheses is that recently performed assays show no cell loss during the first days after irradiation , while saliva flow is dramatically diminished .',
  'The central problem with such data is that the cell-killing component of radiation damage may mask the effects associated with repair of precancerous lesions .',
  'A major drawback of radiotherapy is the accelerated growth of the surviving tumor cells .',
  'Gut bacteria-associated sepsis is a serious concern in patients with gastrointestinal acute radiation syndrome ( GIARS ) .',
  'The toxic effects of radiation and cytostatics are a serious clinical problem connected with the physiologically or pathologically reduced antioxidant defense of normal tissues involved in the therapy .',
  'Radiation-induced dermatitis is a debilitating clinical problem in cancer patients undergoing cancer radiation therapy .',
  'Radiation therapy is widely used for the treatment of various types of cancers ; however , radiation-induced skin injury remains a serious concern .',
  'Recently , the late adverse events associated with radiotherapy ( especially extended field radiation therapy ) , such as cardiovascular disease and secondary cancers , become a serious problem for long-term lymphoma survivors .',
  'Radiation-induced enteritis is a serious clinical problem for which there is currently no recommended standard management .',
  'Radiation necrosis ( RN ) after intensive radiation therapy is a serious problem .',
  'The acute radiation morbidity may be a serious problem for the patient and may be decreased by pharmacological approaches .',
  'Skin injuries caused by burns or radiation remain a serious concern in terms of clinical therapy .',
  'Radiotherapy‑induced lacrimal gland injury is a serious clinical problem currently lacking satisfactory therapeutic strategies .',
  'Damage to intestine is a serious problem after accidental radiation exposure .',
  'The late side effects of external beam irradiation in patients with retinoblastoma such as orbital bony growth retardation , are a serious problem in adolescence .',
  'Despite manifestation of rates of a fatal lung bleeding comparable to those seen with conventional radiotherapy for endobronchial tumors , the overall rate of G5 toxicity is of potential concern .',
  'Radiation-induced skin injury remains a serious concern for radiation therapy .',
  'Radiation induced hemorrhage proctitis : a vexing problem .',
  'Of the late complications in Group B a serious problem was the development of severe radiation-induced fibrosis leading to microcystis and a cystectomy was indispensable in one of the patients .',
  'The augmentation of radiation damage by cancer chemotherapeutic agents is a serious problem in a wide range of tissues , but a problem which can be dealt with by accurate knowledge as to the dose-effect factor and appropriate modification of the radiation treatment .',
  'Radiation enteritis is a severe problem in patients receiving irradiation of the abdomen or pelvis in the course of cancer treatment .',
  'Radiation-induced skin injury remains a serious concern for cancer radiotherapy , radiation accidents and occupational exposure , and the damage mainly occurs due to apoptosis and reactive oxygen species ( ROS ) generation .',
  'Radiation-induced skin injury is a serious concern during radiotherapy .',
  'Lung toxicity is a serious concern during total body irradiation ( TBI ) .',
  'Persistent disease after radiotherapy was a serious problem in advanced stages , especially in view of nonacceptance of salvage surgery by a significant proportion of patients .',
  'Radiation-induced skin injury is a serious concern during radiotherapy and radiation accidents .',
  'Radiation-induced reactive oxygen species ( ROS ) can damage DNA and most other biological macromolecules in skin and radiation-induced skin injury is a serious concern for radiation therapy .',
  'Radiation damage to normal tissues is a serious concern in radiation therapy .',
  'We found a serious complication rate of 3 % for all patients treated , the major problem being radiation ileitis .',
  'Radiation-induced skin injury remains a serious concern during radiotherapy .',
  'Radiotherapy is one of the most important modalities in cancer treatment ; however , normal tissue damage is a serious concern .',
  'Radiation-induced gastric injury is a serious concern that may limit the duration and the delivered dose of radiation .',
  'Progressive radiation-induced cystitis can become a serious clinical problem the therapeutic solution of which is limited and almost invariably aggressive .',
  'Radiation-induced vascular injury can be a serious problem for cancer survivors .'],
 'carcinoma': ['Although not rare, vascular lesions occurring in the lips sometimes poses a difficult in properly diagnosing and handling them.',
  'Liver hepatocellular carcinoma (HCC) is one of the most malignant tumors, of which prognosis is unsatisfactory in most cases and metastatic of HCC often results in poor prognosis',
  'Oral Squamous Cell Carcinoma (OSCC) is the most common malignancy of the oral cavity',
  'Hepatocellular carcinoma (HCC) is an epithelial cancer that originates from hepatocytes and it is the most common primary malignant tumor of the liver',
  'Oral squamous cell carcinoma (OSCC) is among the most frequent oral cancers in individuals under 40',
  'Primary Hepatic Epithelioid Hemangioendothelioma is an extremely rare tumor of vascular origin',
  'Radiofrequency ablation ( RFA ) for the treatment of small hepatocellular carcinoma ( HCC ) has a drawback of high recurrence rate .',
  'Head and neck squamous cell carcinoma ( HNSCC ) is considered a serious public health problem in many countries .',
  'Oral cancer presents a serious public health problem in south-east Asian countries .',
  'Oral cancer is considered as a serious health problem resulting in high morbidity and mortality .',
  'Hepatocellular carcinoma ( HCC ) is a serious health problem worldwide because of its association with hepatitis B and C viruses .',
  'Oral cancer is a serious public health problem , with over 200,000 new cases reported annually worldwide , two-thirds of which occur in developing countries .',
  'Hepatocellular carcinoma ( HCC ) is a severe global health problem .',
  'Hepatocellular carcinoma is a serious health problem worldwide and is endemic in some areas because of its association with hepatitis B and C viruses ( in 20 % of cases ) .',
  'Oral carcinoma is the sixth most common cancer and is a serious public health problem , and tongue squamous cell carcinoma ( TSCC ) is the most common type of oral carcinoma .',
  'Trismus is a serious problem for some patients after oral and oropharyngeal cancer , and it has a detrimental impact on quality of life and function .',
  'Oral Squamous Cell Carcinoma ( OSCC ) remains a serious health problem worldwide .',
  'Reducing the incidence of hepatocellular carcinoma ( HCC ) in HIV-infected patients has become a serious problem when managing these patients .',
  'Oral squamous cell carcinoma ( OSCC ) is a serious public health problem , due to its high mortality rate and worldwide rising incidence .',
  'Treatment of liver malignancies , in particular hepatocellular carcinoma , remains a serious problem because of the difficulty of delivering adequate therapeutic agents to the lesions while sparing the surrounding normal tissue .',
  "Oral cancer is a serious problem owing to its poor prognosis and destruction of patients ' eating ability as well as facial appearance .",
  'Oral cancer : a serious and growing problem .',
  'Oral and pharynx cancer represent a serious global problem , reaching an incidence of half a million cases annually .',
  'Oral Cancer ( OC ) is a serious and growing problem which constitutes a huge burden on people in more and less economically developed countries alike .',
  'Oral cancer is a serious problem for public health causing great morbidity and mortality , a situation that has not improved in decades .',
  'It is also an important cause of hepatocellular carcinoma and is likely to remain a serious health problem resulting in substantial morbidity and mortality for several decades to come .',
  'Oral squamous cell carcinoma ( OSCC ) , the most common head and neck malignancy , represents a serious public health problem .',
  'A lack of effective prognostic biomarkers and molecular targets is a serious problem in hepatocellular carcinoma .',
  'Oral squamous cell carcinoma ( OSCC ) is a serious public health problem caused primarily by smoking and alcohol consumption or human papillomavirus .',
  'Advanced hepatocellular carcinoma ( HCC ) is a serious public health problem , with no effective cure at present .',
  'The prevalence of head and neck tumors has continually increased over the past decades , which is a serious medical and social problem .',
  'Oral cancer is the sixth most common cancer in the world , and it continues to represent a serious public health problem .',
  'OSCC remains a serious oral health problem in northern Thailand , and it has not been resolved among young adults .',
  'While the prevalence of dental caries and periodontal conditions was low , oral cancer and OPMDs is a serious concern .',
  'Oral mucositis is a serious problem that affects a significant number of hematopoietic cell transplant ( HCT ) patients .',
  'Hepatocellular carcinoma ( HCC ) is increasingly known as a serious , worldwide public health concern .',
  'HCC is one of the main types of liver cancer , and has become a serious public health problem , due to its high incidence mainly in Southeast Asia and Africa .',
  'Oral cancer is a serious problem growing in incidence in many parts of the world ; it is considered the sixth most common cancer and despite sophisticated surgical and radiotherapeutic modalities , oral squamous cell carcinoma , which represents 90 % of oral cancers , is characterized by poor prognosis and a low survival rate .',
  'Hepatocellular carcinoma , ( HCC ) is a serious health problem .',
  'Hepatocellular carcinoma ( HCC ) is a primary malignant tumor of the liver that represents a serious public health problem all over the world , corresponding to the third cause of cancer death worldwide .',
  'Through-and-through oral cancer ( T4 + ) involving contiguous mucosa , mandible , and skin is a devastating disease with poor prognosis and represents one of the most difficult reconstructive challenges in head and neck surgery .',
  'Hepatocellular carcinoma ( HCC ) is a common cancer that affects people worldwide with high morbidity and mortality , and its resistance to current chemotherapeutic drugs is a serious concern .',
  'Head and neck cancer ( HNC ) is a serious health problem worldwide and tobacco smoke is a main causative factor for this malignancy .',
  'Oral squamous cell carcinoma ( OSCC ) is a serious global health problem .',
  'Oral carcinoma is a serious public health problem and the leading cause of head and neck cancer mortality worldwide .',
  'Betel quid chewing plays a significant role in the development of oral cancer , yet the high prevalence of betel quid use remains a serious health problem in Taiwan , especially among indigenous Taiwanese .',
  'Oral cancer represents a serious public health problem worldwide .',
  'Cancer is considered as a serious health problem in public with an increasing number of cancer patients reported every year hence public health awareness/knowledge on oral cancers oral potentially malignant disorders ( OPMDs ) and their risk factors is crucial for prevention and early detection of OPMD and it is important to prevent transformation of oral cancer .',
  'Oral cancer is a serious and growing problem in many developing and developed countries .',
  'Increasing immigration from South Asia , where oral cancer is one of the most common cancers in adults , suggests that this disease will probably pose a serious public health problem in the United States .',
  'Hepatocellular carcinoma is a serious health problem worldwide , especially in Asian countries , such as China .',
  'Head and neck squamous cell carcinoma ( HNSCC ) and especially oral squamous cell carcinoma ( OSCC ) have been a serious and ongoing concern .',
  'Oral and pharyngeal cancer is still a serious health problem with an annual incidence of about 13,000 in Germany .',
  'The risk of such a serious side effect , likely related to a direct toxic effect of acetic acid , should be of concern when considering percutaneous treatment of hepatocellular carcinoma .',
  'Cancer of the lip , mouth and pharynx is a serious health problem .',
  'Mouth cancer remains a serious health problem in many parts of the world with many regions reporting increasing incidence rates particularly in males .',
  'Tongue cancer remains a serious health problem in many countries including India ( male incidence rates up to 6.5 per 100,000 per annum ) and parts of Europe ( male incidence rates in France up to 8.0 per 100,000 per annum ) .',
  'Initial presentation of hepatocellular carcinoma ( HCC ) at an advanced stage in patients under a regular surveillance program is a devastating problem .',
  'Oral cancer ( OC ) is a serious health problem .',
  'Detection of hepatocellular carcinoma ( HCC ) in cirrhotic patients remains a serious , unsolved problem , and the risk factors for acute variceal bleeding ( AVB ) in HCC patients remain unclear .',
  'Local recurrence of hepatocellular carcinoma ( HCC ) after local ablation therapy ( LAT ) is a serious problem ; however , the optimal treatment strategy remains unclear .',
  'Oral and pharyngeal cancer is still a serious public health problem with more than 10,000 new cases every year in Germany , more than 4,000 patients die of this tumour each year .',
  'As compared with the rates from India and the general Taiwanese population , the study community encountered a serious problem of oral lesions .',
  'Radiofrequency ablation ( RFA ) and transarterial chemoembolization ( TACE ) have been applied for treating hepatocellular carcinoma ( HCC ) , but procedure-related complications can be a serious problem .',
  'Lymph node metastasis is a serious problem for oral cancer ; we therefore evaluated the impact of D90 on the migration and invasion of OSCC cells .',
  'Oral cancer continues to be a serious problem in the UK and it is well known that prevention and early recognition of potentially malignant lesions will provide the best prognosis .'],
 'reflux': ['Laryngopharyngeal reflux symptoms assessed with the reflux symptom index can overlap with non-allergic rhinitis symptoms.',
  'Despite the fact that researchers have made significant progress in elucidating pathophysiology of esophageal diseases, the understanding of esophageal motility alterations in patients with eosinophilic esophagitis is in its infancy and current published medical literature remains rather scarce on this topic',
  'Thus the problem with reflux is that gastric juice appears in the oesophagus , an area without any natural protection from proteolytic damage .',
  'Gastroesophageal reflux disease has become a serious problem not only for general practitioners but for other specialists as well .',
  'In this study , we considered that microscopic esophagitis does not always accompany reflux , and the lack of reliable diagnostic histologic criteria is still a serious problem for pathologists .',
  'Gastroesophageal reflux disorder ( GERD ) is a serious health problem in the Western world , with prevalence rates between 9 and 42 % .',
  'Gastroesophageal reflux disease is a serious clinical problem , which can significantly impair health-related quality of life , thus having global implications for patients .',
  'Gastro-esophageal reflux disease ( GERD ) is a serious health and social problem leading to a considerable decrease in the quality of life of patients .',
  'The presence of severe complications from gastroesophageal reflux disease in " asymptomatic " infants and children is a troublesome and not yet fully defined problem .',
  'Abnormal gastroesophageal reflux after percutaneous endoscopic gastrostomy is a serious problem in neurologically impaired children .',
  'Gastroesophageal reflux disease ( GERD ) has been a serious health and social problem .',
  'Gastroesophageal reflux disease is a serious clinical problem .',
  'The extraesophageal manifestations of GERD in elderly patients are a serious clinical problem calling for considerable attention .',
  'Although the causative mechanism of NAB is unclear , this phenomenon is a serious problem for patients with high grade reflux esophagitis .',
  'Recurrent gastroesophageal reflux disease ( GERD ) after gastroesophageal surgery is a troublesome problem .',
  'Refractory GERD is a serious clinical problem .',
  'Patients with severe reflux esophagitis unresponsive to standard medical therapy constitute a vexing clinical problem .',
  'This phenomenon is a serious problem for patients who require strict control of their gastric acid secretions .'],
 'gastroesophageal': ['Laryngopharyngeal reflux symptoms assessed with the reflux symptom index can overlap with non-allergic rhinitis symptoms.',
  'Despite the fact that researchers have made significant progress in elucidating pathophysiology of esophageal diseases, the understanding of esophageal motility alterations in patients with eosinophilic esophagitis is in its infancy and current published medical literature remains rather scarce on this topic',
  'Thus the problem with reflux is that gastric juice appears in the oesophagus , an area without any natural protection from proteolytic damage .',
  'Gastroesophageal reflux disease has become a serious problem not only for general practitioners but for other specialists as well .',
  'In this study , we considered that microscopic esophagitis does not always accompany reflux , and the lack of reliable diagnostic histologic criteria is still a serious problem for pathologists .',
  'Gastroesophageal reflux disorder ( GERD ) is a serious health problem in the Western world , with prevalence rates between 9 and 42 % .',
  'Gastroesophageal reflux disease is a serious clinical problem , which can significantly impair health-related quality of life , thus having global implications for patients .',
  'Gastro-esophageal reflux disease ( GERD ) is a serious health and social problem leading to a considerable decrease in the quality of life of patients .',
  'The presence of severe complications from gastroesophageal reflux disease in " asymptomatic " infants and children is a troublesome and not yet fully defined problem .',
  'Abnormal gastroesophageal reflux after percutaneous endoscopic gastrostomy is a serious problem in neurologically impaired children .',
  'Gastroesophageal reflux disease ( GERD ) has been a serious health and social problem .',
  'Gastroesophageal reflux disease is a serious clinical problem .',
  'The extraesophageal manifestations of GERD in elderly patients are a serious clinical problem calling for considerable attention .',
  'Although the causative mechanism of NAB is unclear , this phenomenon is a serious problem for patients with high grade reflux esophagitis .',
  'Recurrent gastroesophageal reflux disease ( GERD ) after gastroesophageal surgery is a troublesome problem .',
  'Refractory GERD is a serious clinical problem .',
  'Patients with severe reflux esophagitis unresponsive to standard medical therapy constitute a vexing clinical problem .',
  'This phenomenon is a serious problem for patients who require strict control of their gastric acid secretions .'],
 'esophagitis': ['Laryngopharyngeal reflux symptoms assessed with the reflux symptom index can overlap with non-allergic rhinitis symptoms.',
  'Despite the fact that researchers have made significant progress in elucidating pathophysiology of esophageal diseases, the understanding of esophageal motility alterations in patients with eosinophilic esophagitis is in its infancy and current published medical literature remains rather scarce on this topic',
  'Thus the problem with reflux is that gastric juice appears in the oesophagus , an area without any natural protection from proteolytic damage .',
  'Gastroesophageal reflux disease has become a serious problem not only for general practitioners but for other specialists as well .',
  'In this study , we considered that microscopic esophagitis does not always accompany reflux , and the lack of reliable diagnostic histologic criteria is still a serious problem for pathologists .',
  'Gastroesophageal reflux disorder ( GERD ) is a serious health problem in the Western world , with prevalence rates between 9 and 42 % .',
  'Gastroesophageal reflux disease is a serious clinical problem , which can significantly impair health-related quality of life , thus having global implications for patients .',
  'Gastro-esophageal reflux disease ( GERD ) is a serious health and social problem leading to a considerable decrease in the quality of life of patients .',
  'The presence of severe complications from gastroesophageal reflux disease in " asymptomatic " infants and children is a troublesome and not yet fully defined problem .',
  'Abnormal gastroesophageal reflux after percutaneous endoscopic gastrostomy is a serious problem in neurologically impaired children .',
  'Gastroesophageal reflux disease ( GERD ) has been a serious health and social problem .',
  'Gastroesophageal reflux disease is a serious clinical problem .',
  'The extraesophageal manifestations of GERD in elderly patients are a serious clinical problem calling for considerable attention .',
  'Although the causative mechanism of NAB is unclear , this phenomenon is a serious problem for patients with high grade reflux esophagitis .',
  'Recurrent gastroesophageal reflux disease ( GERD ) after gastroesophageal surgery is a troublesome problem .',
  'Refractory GERD is a serious clinical problem .',
  'Patients with severe reflux esophagitis unresponsive to standard medical therapy constitute a vexing clinical problem .',
  'This phenomenon is a serious problem for patients who require strict control of their gastric acid secretions .'],
 'flap': ['Silicone sheet is commonly used for scar management but hard to apply to irregular surfaces or mobile areas, and difficult to conceal.',
  'Patients, particularly those who are young, often develop noticeable orthopaedic scars',
  'The Brunelli flap is a good technique to cover small and moderate defects of the thumb , although the drawback of this procedure is the lack of sensory recovery .',
  'A major drawback of the DIEP flap is the compromised venous drainage in the distal area , which is the rationale behind the creation of additional venous anastomoses for better flap survival .',
  'Unpredictability in graft retention remains a significant drawback of fat grafting .',
  'A drawback of an open RAM harvest is donor site morbidity , and minimally invasive techniques for flap harvesting have been previously proposed but involve vertical division of the rectus fascia .',
  'Autologous fat is a good option in many patients with the major drawback of unpredictable longevity , which may require a secondary procedure .',
  'Clinical use of autologous fat grafts for facial soft-tissue augmentation has grown in popularity in the plastic surgery community , despite a perceived drawback of unpredictable results .',
  'Donor site morbidity is a significant drawback of the radial forearm flap .',
  'Autologous fat grafting is a prevalent technique used for soft-tissue augmentation ; however , the poor survival rate of the grafted tissue remains a drawback of this method .',
  'A serious drawback of the deep inferior epigastric perforator ( DIEP ) flap is an abdominal scar that is too high .',
  'To overcome a major drawback of the inferior rectus abdominis free flap , unpleasant thickness in a obese patient , a method of extreme thinning of the flap has been introduced .',
  'A major drawback of the current soft-tissue fillers is their inability to induce cell infiltration and new tissue formation .',
  'Random-pattern skin flaps are used widely in plastic surgery , but necrosis resulting from ischaemia in the distal sections of the flap is a serious problem .',
  'The management of skin graft donor area has been a troublesome problem in reconstructive surgery .',
  'Reduced skin flap survival due to ischemia is a serious concern during reconstructive cosmetic surgery .',
  'In Group 3 , there was a severe reduction of blood flow in the flap and no flaps survived ; however , all the flaps in Group 2 survived totally with no problem .',
  'Flap necrosis due to blood circulation disorders is a serious problem in reconstructive surgery .',
  'Skin flap necrosis is a serious problem in reconstructive head and neck surgery .',
  'However , flap necrosis remains a serious problem .',
  'Venous insufficiency after microsurgical replantation/revascularization remained to be a vexing problem for finger failure , despite the level of amputation .',
  'Necrosis of surgically transferred flaps due to ischemia is a serious wound problem .'],
 'reconstructive': ['Silicone sheet is commonly used for scar management but hard to apply to irregular surfaces or mobile areas, and difficult to conceal.',
  'Patients, particularly those who are young, often develop noticeable orthopaedic scars',
  'The Brunelli flap is a good technique to cover small and moderate defects of the thumb , although the drawback of this procedure is the lack of sensory recovery .',
  'A major drawback of the DIEP flap is the compromised venous drainage in the distal area , which is the rationale behind the creation of additional venous anastomoses for better flap survival .',
  'Unpredictability in graft retention remains a significant drawback of fat grafting .',
  'A drawback of an open RAM harvest is donor site morbidity , and minimally invasive techniques for flap harvesting have been previously proposed but involve vertical division of the rectus fascia .',
  'Autologous fat is a good option in many patients with the major drawback of unpredictable longevity , which may require a secondary procedure .',
  'Clinical use of autologous fat grafts for facial soft-tissue augmentation has grown in popularity in the plastic surgery community , despite a perceived drawback of unpredictable results .',
  'Donor site morbidity is a significant drawback of the radial forearm flap .',
  'Autologous fat grafting is a prevalent technique used for soft-tissue augmentation ; however , the poor survival rate of the grafted tissue remains a drawback of this method .',
  'A serious drawback of the deep inferior epigastric perforator ( DIEP ) flap is an abdominal scar that is too high .',
  'To overcome a major drawback of the inferior rectus abdominis free flap , unpleasant thickness in a obese patient , a method of extreme thinning of the flap has been introduced .',
  'A major drawback of the current soft-tissue fillers is their inability to induce cell infiltration and new tissue formation .',
  'Random-pattern skin flaps are used widely in plastic surgery , but necrosis resulting from ischaemia in the distal sections of the flap is a serious problem .',
  'The management of skin graft donor area has been a troublesome problem in reconstructive surgery .',
  'Reduced skin flap survival due to ischemia is a serious concern during reconstructive cosmetic surgery .',
  'In Group 3 , there was a severe reduction of blood flow in the flap and no flaps survived ; however , all the flaps in Group 2 survived totally with no problem .',
  'Flap necrosis due to blood circulation disorders is a serious problem in reconstructive surgery .',
  'Skin flap necrosis is a serious problem in reconstructive head and neck surgery .',
  'However , flap necrosis remains a serious problem .',
  'Venous insufficiency after microsurgical replantation/revascularization remained to be a vexing problem for finger failure , despite the level of amputation .',
  'Necrosis of surgically transferred flaps due to ischemia is a serious wound problem .'],
 'dermatitis': ['Ponesimod is currently the only S1P receptor modulator studied in psoriasis.',
  'Psoriasis is one of the most prevalent immune mediated skin diseases.',
  'Psoriasis is associated with dyslipidemia and metabolic syndrome, and has been linked to an increased cardiovascular risk.',
  'Eczema is a common childhood condition, causing dry and itchy skin which can be difficult to manage',
  'Atopic dermatitis (AD) is a common inflammatory skin disease in both adults and children',
  'Allergic contact dermatitis is a common occupational skin disease among healthcare workers (HCWs)',
  'Atopic dermatitis is a chronically relapsing inflammatory skin condition that is burdensome for individuals with the disease, their families, and for society as a whole',
  'While the pathogenesis of contact allergy in recent years has increasingly focused on the mechanisms of the innate immune response, valid therapeutic options are still lacking',
  'The problem in the treatment of bullous autoimmune dermatoses with long-term corticosteroids is that the high doses cause side-effects .',
  'Conclusion The lack of atrophogenic properties of SDZ ASM 981 1 % cream in this short-term study demonstrates its potential as long-term treatment for inflammatory skin diseases , thus overcoming a major drawback of topical steroids .',
  'Ingenol mebutate ( IM ) , a novel agent for field therapy of actinic keratosis ( AK ) , has a drawback of inducing local skin reactions ( LSRs ) , which may cause discomfort in patients .',
  'Hand dermatitis can be a serious health problem in healthcare workers .',
  'Atopic Dermatitis affects both children and adults and is a serious health concern in many countries .',
  'Gastrointestinal complications are more common in children than in adults and present a serious problem with dermatomyositis .',
  'In relation to the incidence and nature of this disease , as well as to health care costs , it can be concluded that psoriasis represents not only a serious medicosocial but also an economic and public problem .',
  'Patients with chronic atopic dermatitis can become unresponsive to standard immunosuppressive therapy and thus pose a serious therapeutic problem .',
  'Contact dermatitis is a serious public health and dermatologic concern .',
  'Atopic dermatitis is a serious health problem in Poland .',
  'Atopic diseases are a serious problem of current medicine due to epidemiological range .',
  'Allergic contact dermatitis ( ACD ) represents a severe health problem with increasing worldwide prevalence .',
  'Allergic contact dermatitis is a serious health problem .',
  'Skin sensitivity is a serious problem for many people , and it can be induced by various factors such as UV irradiation , physical and mental stresses , air pollution , dry air and so on .',
  'Chronic itch is a severe problem that diminishes quality of life .',
  'Parthenium dermatitis is a serious problem in India .',
  'Allergic contact dermatitis ( ACD ) represents a severe health problem with increasing worldwide prevalence .',
  'Contact allergy to corticosteroids becomes a serious problem in the treatment of chronic inflammatory dermatoses such as AD .',
  'With an estimated prevalence of 12 % for preschool children and 3 % for adults , atopic eczema is a serious public health problem .',
  'Air-borne contact dermatitis caused by Parthenium hysterophorus is a serious problem in India .',
  'Dermatological complications can be a serious problem in treating pediatric and adolescent patients of all ages with CSII and/or CGM .',
  'Allergic contact dermatitis is a serious health problem .',
  'A study , in which 81 dental workers referred to dermatologists for a variety of adverse reactions were patch tested , showed work-related dermatoses to represent a serious problem for dental staff , sometimes entailing occupational disability and re-schooling .',
  'As psoriasis increasingly gains recognition as a serious chronic autoimmune skin disease with long-term impairment on the life course , and not mainly a cosmetic problem , nurses are highly challenged to develop efficient education to support patient self-management .',
  'Calcinosis is a devastating complication of juvenile dermatomyositis and a challenging therapeutic problem .',
  'Methylchloroisothiazolinone ( MCI ) and methylisothiazolinone ( MI ) contact dermatitis is a severe problem .'],
 'atopic': ['Ponesimod is currently the only S1P receptor modulator studied in psoriasis.',
  'Psoriasis is one of the most prevalent immune mediated skin diseases.',
  'Psoriasis is associated with dyslipidemia and metabolic syndrome, and has been linked to an increased cardiovascular risk.',
  'Eczema is a common childhood condition, causing dry and itchy skin which can be difficult to manage',
  'Atopic dermatitis (AD) is a common inflammatory skin disease in both adults and children',
  'Allergic contact dermatitis is a common occupational skin disease among healthcare workers (HCWs)',
  'Atopic dermatitis is a chronically relapsing inflammatory skin condition that is burdensome for individuals with the disease, their families, and for society as a whole',
  'While the pathogenesis of contact allergy in recent years has increasingly focused on the mechanisms of the innate immune response, valid therapeutic options are still lacking',
  'The problem in the treatment of bullous autoimmune dermatoses with long-term corticosteroids is that the high doses cause side-effects .',
  'Conclusion The lack of atrophogenic properties of SDZ ASM 981 1 % cream in this short-term study demonstrates its potential as long-term treatment for inflammatory skin diseases , thus overcoming a major drawback of topical steroids .',
  'Ingenol mebutate ( IM ) , a novel agent for field therapy of actinic keratosis ( AK ) , has a drawback of inducing local skin reactions ( LSRs ) , which may cause discomfort in patients .',
  'Hand dermatitis can be a serious health problem in healthcare workers .',
  'Atopic Dermatitis affects both children and adults and is a serious health concern in many countries .',
  'Gastrointestinal complications are more common in children than in adults and present a serious problem with dermatomyositis .',
  'In relation to the incidence and nature of this disease , as well as to health care costs , it can be concluded that psoriasis represents not only a serious medicosocial but also an economic and public problem .',
  'Patients with chronic atopic dermatitis can become unresponsive to standard immunosuppressive therapy and thus pose a serious therapeutic problem .',
  'Contact dermatitis is a serious public health and dermatologic concern .',
  'Atopic dermatitis is a serious health problem in Poland .',
  'Atopic diseases are a serious problem of current medicine due to epidemiological range .',
  'Allergic contact dermatitis ( ACD ) represents a severe health problem with increasing worldwide prevalence .',
  'Allergic contact dermatitis is a serious health problem .',
  'Skin sensitivity is a serious problem for many people , and it can be induced by various factors such as UV irradiation , physical and mental stresses , air pollution , dry air and so on .',
  'Chronic itch is a severe problem that diminishes quality of life .',
  'Parthenium dermatitis is a serious problem in India .',
  'Allergic contact dermatitis ( ACD ) represents a severe health problem with increasing worldwide prevalence .',
  'Contact allergy to corticosteroids becomes a serious problem in the treatment of chronic inflammatory dermatoses such as AD .',
  'With an estimated prevalence of 12 % for preschool children and 3 % for adults , atopic eczema is a serious public health problem .',
  'Air-borne contact dermatitis caused by Parthenium hysterophorus is a serious problem in India .',
  'Dermatological complications can be a serious problem in treating pediatric and adolescent patients of all ages with CSII and/or CGM .',
  'Allergic contact dermatitis is a serious health problem .',
  'A study , in which 81 dental workers referred to dermatologists for a variety of adverse reactions were patch tested , showed work-related dermatoses to represent a serious problem for dental staff , sometimes entailing occupational disability and re-schooling .',
  'As psoriasis increasingly gains recognition as a serious chronic autoimmune skin disease with long-term impairment on the life course , and not mainly a cosmetic problem , nurses are highly challenged to develop efficient education to support patient self-management .',
  'Calcinosis is a devastating complication of juvenile dermatomyositis and a challenging therapeutic problem .',
  'Methylchloroisothiazolinone ( MCI ) and methylisothiazolinone ( MI ) contact dermatitis is a severe problem .'],
 'psoriasis': ['Ponesimod is currently the only S1P receptor modulator studied in psoriasis.',
  'Psoriasis is one of the most prevalent immune mediated skin diseases.',
  'Psoriasis is associated with dyslipidemia and metabolic syndrome, and has been linked to an increased cardiovascular risk.',
  'Eczema is a common childhood condition, causing dry and itchy skin which can be difficult to manage',
  'Atopic dermatitis (AD) is a common inflammatory skin disease in both adults and children',
  'Allergic contact dermatitis is a common occupational skin disease among healthcare workers (HCWs)',
  'Atopic dermatitis is a chronically relapsing inflammatory skin condition that is burdensome for individuals with the disease, their families, and for society as a whole',
  'While the pathogenesis of contact allergy in recent years has increasingly focused on the mechanisms of the innate immune response, valid therapeutic options are still lacking',
  'The problem in the treatment of bullous autoimmune dermatoses with long-term corticosteroids is that the high doses cause side-effects .',
  'Conclusion The lack of atrophogenic properties of SDZ ASM 981 1 % cream in this short-term study demonstrates its potential as long-term treatment for inflammatory skin diseases , thus overcoming a major drawback of topical steroids .',
  'Ingenol mebutate ( IM ) , a novel agent for field therapy of actinic keratosis ( AK ) , has a drawback of inducing local skin reactions ( LSRs ) , which may cause discomfort in patients .',
  'Hand dermatitis can be a serious health problem in healthcare workers .',
  'Atopic Dermatitis affects both children and adults and is a serious health concern in many countries .',
  'Gastrointestinal complications are more common in children than in adults and present a serious problem with dermatomyositis .',
  'In relation to the incidence and nature of this disease , as well as to health care costs , it can be concluded that psoriasis represents not only a serious medicosocial but also an economic and public problem .',
  'Patients with chronic atopic dermatitis can become unresponsive to standard immunosuppressive therapy and thus pose a serious therapeutic problem .',
  'Contact dermatitis is a serious public health and dermatologic concern .',
  'Atopic dermatitis is a serious health problem in Poland .',
  'Atopic diseases are a serious problem of current medicine due to epidemiological range .',
  'Allergic contact dermatitis ( ACD ) represents a severe health problem with increasing worldwide prevalence .',
  'Allergic contact dermatitis is a serious health problem .',
  'Skin sensitivity is a serious problem for many people , and it can be induced by various factors such as UV irradiation , physical and mental stresses , air pollution , dry air and so on .',
  'Chronic itch is a severe problem that diminishes quality of life .',
  'Parthenium dermatitis is a serious problem in India .',
  'Allergic contact dermatitis ( ACD ) represents a severe health problem with increasing worldwide prevalence .',
  'Contact allergy to corticosteroids becomes a serious problem in the treatment of chronic inflammatory dermatoses such as AD .',
  'With an estimated prevalence of 12 % for preschool children and 3 % for adults , atopic eczema is a serious public health problem .',
  'Air-borne contact dermatitis caused by Parthenium hysterophorus is a serious problem in India .',
  'Dermatological complications can be a serious problem in treating pediatric and adolescent patients of all ages with CSII and/or CGM .',
  'Allergic contact dermatitis is a serious health problem .',
  'A study , in which 81 dental workers referred to dermatologists for a variety of adverse reactions were patch tested , showed work-related dermatoses to represent a serious problem for dental staff , sometimes entailing occupational disability and re-schooling .',
  'As psoriasis increasingly gains recognition as a serious chronic autoimmune skin disease with long-term impairment on the life course , and not mainly a cosmetic problem , nurses are highly challenged to develop efficient education to support patient self-management .',
  'Calcinosis is a devastating complication of juvenile dermatomyositis and a challenging therapeutic problem .',
  'Methylchloroisothiazolinone ( MCI ) and methylisothiazolinone ( MI ) contact dermatitis is a severe problem .'],
 'sleep': ['Sleep disturbances and pain are assumed to be reciprocally linked.',
  'Abnormalities within the insular cortex of the salience and thalamus of the hyperarousal network have been increasingly reported in healthy participants with insomnia symptoms by recent resting-state functional magnetic resonance imaging (rsfMRI) studies.',
  'Restless legs syndrome (RLS) affects 10% of the general population.',
  'A drawback of this approach is that the child is still awakened by wet sheets .',
  'This leads to an underappreciation and undertreatment of sleep disorders , making this group of illnesses a serious health concern .',
  'Excessive daytime sleepiness is a serious medical problem .',
  'Sleep loss or sleep deprivation ( SD ) refers to shorter sleep than average baseline need , and SD has been a serious problem of modern societies which affects health and well-being .',
  'They had a range of neurological and developmental disorders and a severe sleep problem that had not responded to a standardised sleep behaviour advice booklet provided to parents four to six weeks before randomisation .',
  'Sleep deprivation is a serious public health concern in the United States that often goes unnoticed , particularly among college students and young adults .',
  '43 % had no clinical sleep problem , 41 % had a mild clinical sleep problem , 16 % had a moderate clinical sleep problem , none had a severe clinical sleep problem .',
  'Sleeping problems are a serious public health problem , imposing a substantial burden on individuals and society .',
  'Sleep deprivation in women resulting from their modern lifestyle , especially during pregnancy , is a serious concern as it can affect the health of the newborn .',
  'Short sleep duration is a serious problem that not only enhances the risk of various mental and physical disorders , but also affects the productivity in the workplace .',
  'Insomnia is a serious problem with various facets .',
  'Insufficient sleep is a serious problem in adolescents and school start time is thought to be a key contributor .',
  'Although sleep problems are a serious public concern , it is not clear if the presence of depression or multiple comorbid conditions has an additive or multiplicative effect on sleep quality .',
  'Given the well-documented deleterious health effects , poor sleep has become a serious public health concern and increasing efforts are directed toward understanding underlying pathways .',
  'Sleeping sickness has re-emerged as a serious problem in sub-Saharan Africa , with an estimated 100000 deaths each year .',
  'A subgroup of DSPD patients may have a severe problem waking up from REM sleep .',
  'Depression has become a severe global health problem , and sleeping difficulties are typically associated with depression .',
  'The lack of adequate sleep in preschool children is a serious public problem in Japan .',
  'Sleep deprivation is a serious problem facing individuals in many critical societal roles .',
  'The increasing prevalence and the social inequality in difficulties falling asleep among adolescents is a serious public health concern that calls for more attention and efforts .',
  'Sleeping sickness still remains a serious public health problem .',
  'Frequent nightmares can pose a serious clinical problem and in 2001 , Tanskanen et al. found that nightmares increase the risk of suicide .',
  'Moreover , sleep disorders represent a serious problem as they can increase the mortality .',
  'Insomnia is becoming a serious social problem ; so much so that alarm bells are ringing with insomnia listed as one of the refractory diseases of the 21st century .',
  'Sleep difficulties are a serious health problem in children , and interest in using complementary and alternative medicine ( CAM ) therapies to treat sleep is growing .',
  "No statistically significant associations were found between presence of a severe sleep problem and other variables ( e.g. , epilepsy , age , living environment , cause of genetic disorder , parents ' and caregivers ' coping strategies ) .",
  'Insomnia is a serious worldwide health problem that is often comorbid with anxiety .',
  'If sleeplessness has a serious impact on health , it represents a notable public health problem .',
  'Sleep deprivation ( SD ) has become a serious concern worldwide .',
  'Frequent nightmares can pose a serious clinical problem , especially in association with sleep and psychological disturbances , in the general population .',
  '[ Sleep disorders in children -- a serious problem in the modern family . Old-fashioned observations on a current topic ] .',
  'Long and repeated periods of sustained wakefulness constitute a serious problem for shift workers in general and for medical interns in particular .',
  'Sleep problems are highly prevalent among the young and middle-aged adults in our representative sample of young and middle-aged adults and as such represent a serious public mental health problem .',
  'Insomnia is usual , and a serious problem in children with neurological disorders .',
  'Our results suggest that lack of sleep is indeed a severe problem in ICU patients and is accompanied by impairment of normal melatonin secretion .',
  'Personal experience suggests that sleep pattern disturbance ( SPD ) is a serious problem for the patients we serve .',
  'Psychiatric patients often have residual intractable insomnia as a serious problem .',
  'In modern societies , sleep deprivation is a serious health problem .',
  'Insomnia is a very frequent complaint /periodically or permanently it affects about 35 % of the population/ and is a serious sociological problem .',
  'Insufficient sleep is a serious public health problem in college students .',
  'If the true cause of sleeplessness is not recognized and properly treated , insomnia may develop into a severe sleep problem .',
  'Insomnia is therefore under-appreciated and almost certainly under-treated , thus making it a serious health concern .',
  'Insomnia affects 5 - 45 % of non-shift workers , making it a serious public health concern .',
  'Sleep deprivation during pregnancy is a serious public health problem as it can affect the health of pregnant women and newborns .',
  'Sleep disorders are common and a serious problem for millions of older adults .',
  '[ Insomnia . A severe health care problem ] .',
  'Sleep disturbances were very frequent and was a serious problem for 16 % of patients .',
  'Insomnia is a serious medical and social problem , its prevalence in the general population ranges from 9 to 35 %'],
 'insomnia': ['Sleep disturbances and pain are assumed to be reciprocally linked.',
  'Abnormalities within the insular cortex of the salience and thalamus of the hyperarousal network have been increasingly reported in healthy participants with insomnia symptoms by recent resting-state functional magnetic resonance imaging (rsfMRI) studies.',
  'Restless legs syndrome (RLS) affects 10% of the general population.',
  'A drawback of this approach is that the child is still awakened by wet sheets .',
  'This leads to an underappreciation and undertreatment of sleep disorders , making this group of illnesses a serious health concern .',
  'Excessive daytime sleepiness is a serious medical problem .',
  'Sleep loss or sleep deprivation ( SD ) refers to shorter sleep than average baseline need , and SD has been a serious problem of modern societies which affects health and well-being .',
  'They had a range of neurological and developmental disorders and a severe sleep problem that had not responded to a standardised sleep behaviour advice booklet provided to parents four to six weeks before randomisation .',
  'Sleep deprivation is a serious public health concern in the United States that often goes unnoticed , particularly among college students and young adults .',
  '43 % had no clinical sleep problem , 41 % had a mild clinical sleep problem , 16 % had a moderate clinical sleep problem , none had a severe clinical sleep problem .',
  'Sleeping problems are a serious public health problem , imposing a substantial burden on individuals and society .',
  'Sleep deprivation in women resulting from their modern lifestyle , especially during pregnancy , is a serious concern as it can affect the health of the newborn .',
  'Short sleep duration is a serious problem that not only enhances the risk of various mental and physical disorders , but also affects the productivity in the workplace .',
  'Insomnia is a serious problem with various facets .',
  'Insufficient sleep is a serious problem in adolescents and school start time is thought to be a key contributor .',
  'Although sleep problems are a serious public concern , it is not clear if the presence of depression or multiple comorbid conditions has an additive or multiplicative effect on sleep quality .',
  'Given the well-documented deleterious health effects , poor sleep has become a serious public health concern and increasing efforts are directed toward understanding underlying pathways .',
  'Sleeping sickness has re-emerged as a serious problem in sub-Saharan Africa , with an estimated 100000 deaths each year .',
  'A subgroup of DSPD patients may have a severe problem waking up from REM sleep .',
  'Depression has become a severe global health problem , and sleeping difficulties are typically associated with depression .',
  'The lack of adequate sleep in preschool children is a serious public problem in Japan .',
  'Sleep deprivation is a serious problem facing individuals in many critical societal roles .',
  'The increasing prevalence and the social inequality in difficulties falling asleep among adolescents is a serious public health concern that calls for more attention and efforts .',
  'Sleeping sickness still remains a serious public health problem .',
  'Frequent nightmares can pose a serious clinical problem and in 2001 , Tanskanen et al. found that nightmares increase the risk of suicide .',
  'Moreover , sleep disorders represent a serious problem as they can increase the mortality .',
  'Insomnia is becoming a serious social problem ; so much so that alarm bells are ringing with insomnia listed as one of the refractory diseases of the 21st century .',
  'Sleep difficulties are a serious health problem in children , and interest in using complementary and alternative medicine ( CAM ) therapies to treat sleep is growing .',
  "No statistically significant associations were found between presence of a severe sleep problem and other variables ( e.g. , epilepsy , age , living environment , cause of genetic disorder , parents ' and caregivers ' coping strategies ) .",
  'Insomnia is a serious worldwide health problem that is often comorbid with anxiety .',
  'If sleeplessness has a serious impact on health , it represents a notable public health problem .',
  'Sleep deprivation ( SD ) has become a serious concern worldwide .',
  'Frequent nightmares can pose a serious clinical problem , especially in association with sleep and psychological disturbances , in the general population .',
  '[ Sleep disorders in children -- a serious problem in the modern family . Old-fashioned observations on a current topic ] .',
  'Long and repeated periods of sustained wakefulness constitute a serious problem for shift workers in general and for medical interns in particular .',
  'Sleep problems are highly prevalent among the young and middle-aged adults in our representative sample of young and middle-aged adults and as such represent a serious public mental health problem .',
  'Insomnia is usual , and a serious problem in children with neurological disorders .',
  'Our results suggest that lack of sleep is indeed a severe problem in ICU patients and is accompanied by impairment of normal melatonin secretion .',
  'Personal experience suggests that sleep pattern disturbance ( SPD ) is a serious problem for the patients we serve .',
  'Psychiatric patients often have residual intractable insomnia as a serious problem .',
  'In modern societies , sleep deprivation is a serious health problem .',
  'Insomnia is a very frequent complaint /periodically or permanently it affects about 35 % of the population/ and is a serious sociological problem .',
  'Insufficient sleep is a serious public health problem in college students .',
  'If the true cause of sleeplessness is not recognized and properly treated , insomnia may develop into a severe sleep problem .',
  'Insomnia is therefore under-appreciated and almost certainly under-treated , thus making it a serious health concern .',
  'Insomnia affects 5 - 45 % of non-shift workers , making it a serious public health concern .',
  'Sleep deprivation during pregnancy is a serious public health problem as it can affect the health of pregnant women and newborns .',
  'Sleep disorders are common and a serious problem for millions of older adults .',
  '[ Insomnia . A severe health care problem ] .',
  'Sleep disturbances were very frequent and was a serious problem for 16 % of patients .',
  'Insomnia is a serious medical and social problem , its prevalence in the general population ranges from 9 to 35 %'],
 'diarrhea': ['Diarrhea is the most frequent morbidity affecting kenneled dogs in animal shelters.',
  "Traveller's diarrhoea (TD) is the most common infectious problem for travellers, and we lack effective ways of preventing it, apart from antibiotic prophylaxis",
  'The diarrheal syndrome is considered a serious public health problem all over the world and is considered a major cause of morbidity and mortality in developing countries .',
  'Diarrhoea among children under-five is a serious public health problem in many developing countries , including Nepal .',
  'Persistent diarrhea : still a serious public health problem in developing countries .',
  'The poor nutritional status of Aboriginal Australians is a serious and complex public health concern .',
  'The use of marine seaweeds as a source of natural compounds with medicinal purposes is increasing in Western countries in the last decades , becoming an important alternative in the traditional medicine of many developing countries , where diarrhea still remains a severe public health problem , with high rates of mortality and morbidity .',
  'High percentage of infants and children dying with acute infectious diarrhea presents a serious socio-economic and medical problem in Tuzla region of Bosnia and Herzegovina .',
  'Acute gastroenteritis ( AGE ) is a serious global health problem and has been known to cause millions of infant deaths every year .',
  'Diarrheal disease continues to be a serious health problem , especially in developing countries .',
  'Postweaning diarrhea had been a severe problem in this herd for years .',
  'Gastroenteritis is a serious problem among young children in Shiraz Iran and often requires antibiotic therapy as it is commonly superimposed on other debilitating clinical conditions .',
  'Diarrhea is a serious problem affecting 3 - 5 billion people per year around the world , especially children of below 5 years .',
  'Prolonged diarrhea in an adult is a serious problem ; in an infant it is life threatening .',
  'The three California state hospitals for mentally retarded persons have been having a severe problem with amebic and bacillary dysentery and with other infectious diseases of the gastrointestinal tract .',
  'Persistent diarrhoea still a serious and difficult problem .',
  'Gastroenteritis remains a serious problem in Aboriginal children .',
  'Diarrhea is a serious problem in sheep and goat farming , causing great economic losses .',
  'This situation represents a serious problem for the control of diarrheal diseases and children malnutrition .',
  "Traveler 's diarrhea can be a debilitating problem for individuals on international trips .",
  'Primary amenorrhea is a distressing problem for patients as well for parents .',
  'Awareness of a serious Indigenous health problem in Australia did not emerge until the 1960s and 1970s .',
  'Over the past 20 years , gastrointestinal infections in developing countries have been a serious health problem and are the second leading cause of morbidity among all age groups .',
  'Diarrhea is a serious concern worldwide , especially in developing countries .',
  'Diarrhea is a serious public health problem in Ethiopia .',
  "Traveller 's diarrhea , though not life-threatening . is often a vexing problem , which impacts overall function of the traveller",
  'Inappropriate prescribing for ARI and diarrhoea is a serious health problem in many developing countries including Bangladesh .',
  'Diarrheal diseases are a serious public health problem in the Gaza Strip , being the most important cause of hospitalization in infants and responsible for about half of postneonatal deaths , Oral rehydration therapy using oral rehydration solution ( ORS ) , a formula recommended by WHO , has been proven effective in the treatment of dehydration in acute childhood diarrhea .',
  'The findings demonstrate that VAD is a severe public health problem among diarrheic patients in Gondar , Ethiopia .',
  'Infectious diarrheal diseases can be a serious problem in long-term care institutions .',
  'Infectious diarrhoea has been recognised as a serious public health problem for Aboriginal Australians , particularly infants and young children , for more than two decades .',
  'Inappropriate drug use is a serious problem in the control of diarrhoeal diseases .',
  'Diarrhea is a serious public health problem in Mexico and other countries .',
  'Gastroenteritis with dehydration is a serious continuing pediatric problem in Jakarta , constituting 30 % of admissions to Sumber Waras hospital .',
  'As soon as the Institute of Nutrition of Central America and Panama ( INCAP ) began to study the poor nutritional status and stunting of children in the rural villages of Central America , it was apparent that infections , particularly diarrheas , were also a serious problem .',
  'Persistent diarrhoea , a serious health problem , is closely related to malnutrition .',
  'Lack of sanitation affecting billions of people worldwide is a serious public health problem of Ethiopia .',
  'Diarrheal illnesses are a severe public health problem and a major cause of morbidity and mortality in infants and young children , especially in developing countries .'],
 'diarrheal': ['Diarrhea is the most frequent morbidity affecting kenneled dogs in animal shelters.',
  "Traveller's diarrhoea (TD) is the most common infectious problem for travellers, and we lack effective ways of preventing it, apart from antibiotic prophylaxis",
  'The diarrheal syndrome is considered a serious public health problem all over the world and is considered a major cause of morbidity and mortality in developing countries .',
  'Diarrhoea among children under-five is a serious public health problem in many developing countries , including Nepal .',
  'Persistent diarrhea : still a serious public health problem in developing countries .',
  'The poor nutritional status of Aboriginal Australians is a serious and complex public health concern .',
  'The use of marine seaweeds as a source of natural compounds with medicinal purposes is increasing in Western countries in the last decades , becoming an important alternative in the traditional medicine of many developing countries , where diarrhea still remains a severe public health problem , with high rates of mortality and morbidity .',
  'High percentage of infants and children dying with acute infectious diarrhea presents a serious socio-economic and medical problem in Tuzla region of Bosnia and Herzegovina .',
  'Acute gastroenteritis ( AGE ) is a serious global health problem and has been known to cause millions of infant deaths every year .',
  'Diarrheal disease continues to be a serious health problem , especially in developing countries .',
  'Postweaning diarrhea had been a severe problem in this herd for years .',
  'Gastroenteritis is a serious problem among young children in Shiraz Iran and often requires antibiotic therapy as it is commonly superimposed on other debilitating clinical conditions .',
  'Diarrhea is a serious problem affecting 3 - 5 billion people per year around the world , especially children of below 5 years .',
  'Prolonged diarrhea in an adult is a serious problem ; in an infant it is life threatening .',
  'The three California state hospitals for mentally retarded persons have been having a severe problem with amebic and bacillary dysentery and with other infectious diseases of the gastrointestinal tract .',
  'Persistent diarrhoea still a serious and difficult problem .',
  'Gastroenteritis remains a serious problem in Aboriginal children .',
  'Diarrhea is a serious problem in sheep and goat farming , causing great economic losses .',
  'This situation represents a serious problem for the control of diarrheal diseases and children malnutrition .',
  "Traveler 's diarrhea can be a debilitating problem for individuals on international trips .",
  'Primary amenorrhea is a distressing problem for patients as well for parents .',
  'Awareness of a serious Indigenous health problem in Australia did not emerge until the 1960s and 1970s .',
  'Over the past 20 years , gastrointestinal infections in developing countries have been a serious health problem and are the second leading cause of morbidity among all age groups .',
  'Diarrhea is a serious concern worldwide , especially in developing countries .',
  'Diarrhea is a serious public health problem in Ethiopia .',
  "Traveller 's diarrhea , though not life-threatening . is often a vexing problem , which impacts overall function of the traveller",
  'Inappropriate prescribing for ARI and diarrhoea is a serious health problem in many developing countries including Bangladesh .',
  'Diarrheal diseases are a serious public health problem in the Gaza Strip , being the most important cause of hospitalization in infants and responsible for about half of postneonatal deaths , Oral rehydration therapy using oral rehydration solution ( ORS ) , a formula recommended by WHO , has been proven effective in the treatment of dehydration in acute childhood diarrhea .',
  'The findings demonstrate that VAD is a severe public health problem among diarrheic patients in Gondar , Ethiopia .',
  'Infectious diarrheal diseases can be a serious problem in long-term care institutions .',
  'Infectious diarrhoea has been recognised as a serious public health problem for Aboriginal Australians , particularly infants and young children , for more than two decades .',
  'Inappropriate drug use is a serious problem in the control of diarrhoeal diseases .',
  'Diarrhea is a serious public health problem in Mexico and other countries .',
  'Gastroenteritis with dehydration is a serious continuing pediatric problem in Jakarta , constituting 30 % of admissions to Sumber Waras hospital .',
  'As soon as the Institute of Nutrition of Central America and Panama ( INCAP ) began to study the poor nutritional status and stunting of children in the rural villages of Central America , it was apparent that infections , particularly diarrheas , were also a serious problem .',
  'Persistent diarrhoea , a serious health problem , is closely related to malnutrition .',
  'Lack of sanitation affecting billions of people worldwide is a serious public health problem of Ethiopia .',
  'Diarrheal illnesses are a severe public health problem and a major cause of morbidity and mortality in infants and young children , especially in developing countries .'],
 'diarrhoea': ['Diarrhea is the most frequent morbidity affecting kenneled dogs in animal shelters.',
  "Traveller's diarrhoea (TD) is the most common infectious problem for travellers, and we lack effective ways of preventing it, apart from antibiotic prophylaxis",
  'The diarrheal syndrome is considered a serious public health problem all over the world and is considered a major cause of morbidity and mortality in developing countries .',
  'Diarrhoea among children under-five is a serious public health problem in many developing countries , including Nepal .',
  'Persistent diarrhea : still a serious public health problem in developing countries .',
  'The poor nutritional status of Aboriginal Australians is a serious and complex public health concern .',
  'The use of marine seaweeds as a source of natural compounds with medicinal purposes is increasing in Western countries in the last decades , becoming an important alternative in the traditional medicine of many developing countries , where diarrhea still remains a severe public health problem , with high rates of mortality and morbidity .',
  'High percentage of infants and children dying with acute infectious diarrhea presents a serious socio-economic and medical problem in Tuzla region of Bosnia and Herzegovina .',
  'Acute gastroenteritis ( AGE ) is a serious global health problem and has been known to cause millions of infant deaths every year .',
  'Diarrheal disease continues to be a serious health problem , especially in developing countries .',
  'Postweaning diarrhea had been a severe problem in this herd for years .',
  'Gastroenteritis is a serious problem among young children in Shiraz Iran and often requires antibiotic therapy as it is commonly superimposed on other debilitating clinical conditions .',
  'Diarrhea is a serious problem affecting 3 - 5 billion people per year around the world , especially children of below 5 years .',
  'A serious epidemiological problem is the high incidence of infection caused by Clostridium difficile .',
  '[ Colitis precipitated by Clostridium difficile - \u200a  a serious current problem ] .',
  'Accelerating rates of health care-associated infections caused by Clostridium difficile , with increasing recurrence and rising antibiotic resistance rates , have become a serious problem in recent years .',
  'Prolonged diarrhea in an adult is a serious problem ; in an infant it is life threatening .',
  'The three California state hospitals for mentally retarded persons have been having a severe problem with amebic and bacillary dysentery and with other infectious diseases of the gastrointestinal tract .',
  'Persistent diarrhoea still a serious and difficult problem .',
  'A serious epidemiological problem is a strong upward trend in nosocomial infections including infections caused \n by Clostridium difficile .',
  'Gastroenteritis remains a serious problem in Aboriginal children .',
  'The disease caused by the bacterium Clostridium difficile/Clostridium difficile associated disease/diarrhoea ( CDAD ) is becoming a serious problem especially in geriatric patients , who are now relatively often treated by broad-spectrum antibiotics .',
  'Over recent years C. difficile diarrhea has become a serious problem in geriatric units .',
  'C. difficile infection is low in Greek intensive care units , but remains a serious problem among the critically-ill .',
  'Intestinal infections caused by the Clostridium difficile ( CDI ) bacterium currently represent a serious medical problem .',
  'Clostridium difficile is a serious epidemiological problem and particularly dangerous microorganism causing hospital infections .',
  'Diarrhea is a serious problem in sheep and goat farming , causing great economic losses .',
  'This situation represents a serious problem for the control of diarrheal diseases and children malnutrition .',
  "Traveler 's diarrhea can be a debilitating problem for individuals on international trips .",
  'Primary amenorrhea is a distressing problem for patients as well for parents .',
  'Awareness of a serious Indigenous health problem in Australia did not emerge until the 1960s and 1970s .',
  '[i]Clostridium difficile[/i ] infections become a serious problem in terms of nosocomial infections , as well as a consequence of common use of antibiotics .',
  'Over the past 20 years , gastrointestinal infections in developing countries have been a serious health problem and are the second leading cause of morbidity among all age groups .',
  'Recurrence of Clostridium difficile-associated diarrhea ( CDAD ) is a serious and still unsolved problem .',
  'Diarrhea is a serious concern worldwide , especially in developing countries .',
  'Diarrhea is a serious public health problem in Ethiopia .',
  "Traveller 's diarrhea , though not life-threatening . is often a vexing problem , which impacts overall function of the traveller",
  'Inappropriate prescribing for ARI and diarrhoea is a serious health problem in many developing countries including Bangladesh .',
  'Diarrheal diseases are a serious public health problem in the Gaza Strip , being the most important cause of hospitalization in infants and responsible for about half of postneonatal deaths , Oral rehydration therapy using oral rehydration solution ( ORS ) , a formula recommended by WHO , has been proven effective in the treatment of dehydration in acute childhood diarrhea .',
  'The findings demonstrate that VAD is a severe public health problem among diarrheic patients in Gondar , Ethiopia .',
  'Infectious diarrheal diseases can be a serious problem in long-term care institutions .',
  'Infectious diarrhoea has been recognised as a serious public health problem for Aboriginal Australians , particularly infants and young children , for more than two decades .',
  'Inappropriate drug use is a serious problem in the control of diarrhoeal diseases .',
  "Clostridium difficile ( C. difficile ) infection ( CDI ) is a serious problem mostly studied during patients ' index infections .",
  'Among the various infectious diseases , Clostridium difficile infection is associated with a high rate of mortality in elderly individuals and is a serious health problem worldwide , owing to the increasing infection rates .',
  'As the major cause of antibiotic-associated diarrhea , Clostridium difficile is a serious problem in health care facilities worldwide .',
  'Diarrhea is a serious public health problem in Mexico and other countries .',
  'Gastroenteritis with dehydration is a serious continuing pediatric problem in Jakarta , constituting 30 % of admissions to Sumber Waras hospital .',
  'Clostridium difficile infection ( CDI ) is a serious problem in hospitalized patients .',
  'As soon as the Institute of Nutrition of Central America and Panama ( INCAP ) began to study the poor nutritional status and stunting of children in the rural villages of Central America , it was apparent that infections , particularly diarrheas , were also a serious problem .',
  'Persistent diarrhoea , a serious health problem , is closely related to malnutrition .',
  'Lack of sanitation affecting billions of people worldwide is a serious public health problem of Ethiopia .',
  'Diarrheal illnesses are a severe public health problem and a major cause of morbidity and mortality in infants and young children , especially in developing countries .',
  'Clostridium difficile infection ( CDI ) is a serious problem within the healthcare environment where the bacterium causes symptoms ranging from mild diarrhoea to life-threatening colitis .',
  'Clostridium difficile-associated diarrhoea ( CDAD ) is caused by C. difficile toxins A and B and represents a serious emerging health problem .'],
 'aortic': ['Stanford type A acute aortic dissection (A-AAD) extends to the brachiocephalic branches in some patients.',
  'Retrograde type A dissection ( RTAD ) after thoracic endovascular aortic repair ( TEVAR ) has been a major drawback of endovascular treatment .',
  'Recurrent stenosis is a drawback of carotid endarterectomy ( CEA ) , and may lead to recurrent symptoms and reintervention .',
  'Acute aortic dissection is no longer a catastrophic event because this problem can be rapidly diagnosed with current medical technology , and therefore promptly treated with medication and surgery .',
  'Aortic enlargement after hemiarch replacement ( HAR ) for acute type A aortic dissection ( AAAD ) is a serious problem .',
  'Acceptable early results of its management have been reported in recent years , but aortic stump disruption remains a dreaded problem in the remote period .',
  'The combination of coarctation of the aorta in the presence of severe aortic insufficiency poses a serious clinical problem .',
  'Maintaining an adequate cerebral oxygen supply is a serious problem in aortic arch surgery .',
  'Severe postoperative hypertension following carotid endarterectomy is a serious and poorly understood clinical problem associated with an increased mortality rate and increased incidence of neurologic deficit .',
  'Postoperative stroke constitutes a serious problem in cardiac surgery , and atherosclerosis of the ascending aorta is an important risk factor .',
  'Risk in balloon angioplasty of arteries irrigating the brain is a serious problem .',
  'Systolic hypertension after carotid endarterectomy is frequently a serious problem associated with increased mortality and increased incidence of neurologic deficit .',
  'The involvement of internal or common carotid artery by neoplasmatic process usually indicates advanced stage of a disease and is always a serious problem for surgical treatment .',
  'Embolic stroke during arch replacement is a serious concern in patients with shaggy aorta .',
  'Abdominal organ ischemia associated with aortic dissection is a serious problem , although its incidence is not so high .',
  'It is generally known that Stanford type A aortic dissection has up to now been a serious problem of cardiothoracic surgery .',
  'Distal anastomosis during total arch replacement for thoracic aortic aneurysm is at times difficult , and bleeding from it is a serious problem because of its limited surgical exposure .',
  'Acute aortic dissection is a life-threatening condition associated with high morbidity and mortality rates and a long history of challenges to both diagnose and manage this condition successfully .',
  'Bleeding is a serious concern during surgery for acute aortic dissections .',
  'Despite the advances in reconstructive vascular surgery anastomotic pseudoaneurysms have remained a serious problem .',
  'Traumatic carotid artery dissection , if not diagnosed and treated early , is a serious problem with permanent neurological deficit and a high mortality rate of up to 40 % .',
  "Aortic aneurysm is a serious problem in Behçet 's disease , but open surgical therapy carries the risk of recurrent pseudoaneurysm .",
  'This data suggests that an increasing level of aorta-left ventricle pressure difference should raise little problem in the mid-term late stage after surgery but possibly cause a serious problem in the long term .'],
 'carotid': ['Stanford type A acute aortic dissection (A-AAD) extends to the brachiocephalic branches in some patients.',
  'Retrograde type A dissection ( RTAD ) after thoracic endovascular aortic repair ( TEVAR ) has been a major drawback of endovascular treatment .',
  'Recurrent stenosis is a drawback of carotid endarterectomy ( CEA ) , and may lead to recurrent symptoms and reintervention .',
  'Acute aortic dissection is no longer a catastrophic event because this problem can be rapidly diagnosed with current medical technology , and therefore promptly treated with medication and surgery .',
  'Aortic enlargement after hemiarch replacement ( HAR ) for acute type A aortic dissection ( AAAD ) is a serious problem .',
  'Acceptable early results of its management have been reported in recent years , but aortic stump disruption remains a dreaded problem in the remote period .',
  'The combination of coarctation of the aorta in the presence of severe aortic insufficiency poses a serious clinical problem .',
  'Maintaining an adequate cerebral oxygen supply is a serious problem in aortic arch surgery .',
  'Severe postoperative hypertension following carotid endarterectomy is a serious and poorly understood clinical problem associated with an increased mortality rate and increased incidence of neurologic deficit .',
  'Postoperative stroke constitutes a serious problem in cardiac surgery , and atherosclerosis of the ascending aorta is an important risk factor .',
  'Risk in balloon angioplasty of arteries irrigating the brain is a serious problem .',
  'Systolic hypertension after carotid endarterectomy is frequently a serious problem associated with increased mortality and increased incidence of neurologic deficit .',
  'The involvement of internal or common carotid artery by neoplasmatic process usually indicates advanced stage of a disease and is always a serious problem for surgical treatment .',
  'Embolic stroke during arch replacement is a serious concern in patients with shaggy aorta .',
  'Abdominal organ ischemia associated with aortic dissection is a serious problem , although its incidence is not so high .',
  'It is generally known that Stanford type A aortic dissection has up to now been a serious problem of cardiothoracic surgery .',
  'Distal anastomosis during total arch replacement for thoracic aortic aneurysm is at times difficult , and bleeding from it is a serious problem because of its limited surgical exposure .',
  'Acute aortic dissection is a life-threatening condition associated with high morbidity and mortality rates and a long history of challenges to both diagnose and manage this condition successfully .',
  'Bleeding is a serious concern during surgery for acute aortic dissections .',
  'Despite the advances in reconstructive vascular surgery anastomotic pseudoaneurysms have remained a serious problem .',
  'Traumatic carotid artery dissection , if not diagnosed and treated early , is a serious problem with permanent neurological deficit and a high mortality rate of up to 40 % .',
  "Aortic aneurysm is a serious problem in Behçet 's disease , but open surgical therapy carries the risk of recurrent pseudoaneurysm .",
  'This data suggests that an increasing level of aorta-left ventricle pressure difference should raise little problem in the mid-term late stage after surgery but possibly cause a serious problem in the long term .'],
 'aorta': ['Stanford type A acute aortic dissection (A-AAD) extends to the brachiocephalic branches in some patients.',
  'Retrograde type A dissection ( RTAD ) after thoracic endovascular aortic repair ( TEVAR ) has been a major drawback of endovascular treatment .',
  'Recurrent stenosis is a drawback of carotid endarterectomy ( CEA ) , and may lead to recurrent symptoms and reintervention .',
  'Acute aortic dissection is no longer a catastrophic event because this problem can be rapidly diagnosed with current medical technology , and therefore promptly treated with medication and surgery .',
  'Aortic enlargement after hemiarch replacement ( HAR ) for acute type A aortic dissection ( AAAD ) is a serious problem .',
  'Acceptable early results of its management have been reported in recent years , but aortic stump disruption remains a dreaded problem in the remote period .',
  'The combination of coarctation of the aorta in the presence of severe aortic insufficiency poses a serious clinical problem .',
  'Maintaining an adequate cerebral oxygen supply is a serious problem in aortic arch surgery .',
  'Severe postoperative hypertension following carotid endarterectomy is a serious and poorly understood clinical problem associated with an increased mortality rate and increased incidence of neurologic deficit .',
  'Postoperative stroke constitutes a serious problem in cardiac surgery , and atherosclerosis of the ascending aorta is an important risk factor .',
  'Risk in balloon angioplasty of arteries irrigating the brain is a serious problem .',
  'Systolic hypertension after carotid endarterectomy is frequently a serious problem associated with increased mortality and increased incidence of neurologic deficit .',
  'The involvement of internal or common carotid artery by neoplasmatic process usually indicates advanced stage of a disease and is always a serious problem for surgical treatment .',
  'Embolic stroke during arch replacement is a serious concern in patients with shaggy aorta .',
  'Abdominal organ ischemia associated with aortic dissection is a serious problem , although its incidence is not so high .',
  'It is generally known that Stanford type A aortic dissection has up to now been a serious problem of cardiothoracic surgery .',
  'Distal anastomosis during total arch replacement for thoracic aortic aneurysm is at times difficult , and bleeding from it is a serious problem because of its limited surgical exposure .',
  'Acute aortic dissection is a life-threatening condition associated with high morbidity and mortality rates and a long history of challenges to both diagnose and manage this condition successfully .',
  'Bleeding is a serious concern during surgery for acute aortic dissections .',
  'Despite the advances in reconstructive vascular surgery anastomotic pseudoaneurysms have remained a serious problem .',
  'Traumatic carotid artery dissection , if not diagnosed and treated early , is a serious problem with permanent neurological deficit and a high mortality rate of up to 40 % .',
  "Aortic aneurysm is a serious problem in Behçet 's disease , but open surgical therapy carries the risk of recurrent pseudoaneurysm .",
  'This data suggests that an increasing level of aorta-left ventricle pressure difference should raise little problem in the mid-term late stage after surgery but possibly cause a serious problem in the long term .'],
 'allergy': ["Prevalence and severity of cow's milk protein allergy (CMA) in infants are increasing.",
  'Cow milk allergy (CMA) is the most common food allergy in breastfed infants.',
  'Food allergy (FA) is a prevalent condition in the United States, but little is known about its phenotypes in racial minority groups',
  'The basic problem with diagnostic tests such as skin prick test ( SPT ) , measurement of specific IgE ( RAST ) or histamine release from basophils ( HR ) is that in contrast to inhalant allergens , no standardized extracts are commercially available .',
  'A major drawback of oral immunotherapy for food allergy is the possibility of severe side-effects .',
  'A major drawback of oral tolerance ( OT ) induction protocols , however , is the possibility of severe side effects ; thus , we have formulated a hypoallergenic egg product and demonstrate its in vivo capacity to modulate the immune system in the current study .',
  'Food allergy is a serious and growing problem .',
  'The presence of species-specific proteins , different from those declared in label , may be a serious problem for people with allergies .',
  'Anyone who suffers from hayfever will know what a serious problem allergies can be .',
  'Latex allergy is a serious occupational health problem among medical workers , but there are few data regarding its incidence and clinical characteristics in Taiwan .',
  'This has lead to recognition of latex allergy as a serious medical concern .',
  'Food allergies represent a serious problem affecting human health and soy proteins rank among the most allergenic proteins from food origin .',
  'Allergy is a serious and apparently increasing public health problem yet relatively little is known about the types of allergy seen in routine tertiary practice , including their spatial distribution , co-occurrence or referral patterns .',
  'Type I allergy represents a severe health problem in industrialized countries where up to 20 % of the population suffer from allergic rhinitis , conjunctivitis and allergic asthma bronchiale and in severe cases from anaphylaxis , leading to death .',
  'Immediate hypersensitivity to latex protein is a serious and potentially life-threatening problem .',
  'The increase in allergic reactions compels the anaesthetist to exercise great care when administering anaesthetics exclusively intravenously , because anaphylactic or anaphylactoid reactions can become a life-threatening problem for the patient within a very short time .',
  'Latex allergy is a serious problem for health care providers and the general public .',
  'Drug allergic reactions frequently represent a serious diagnostic problem .',
  'Antihistamine use does not appear to be a serious problem .',
  'Many tree nuts are considered to be a serious problem in food safety , because of the presence of causative factors in IgE-mediated food allergies .',
  'Natural rubber latex allergy is a serious medical problem for a growing number of patients and a disabling occupational disease among health care workers .',
  'Allergic conditions present a serious problem for the Polish population .',
  'However , its allergenic reactions , being the main adverse effects ( AEs ) of SHLPI , have been a serious problem of its clinical safety .',
  'The allergic potential of diverse preservatives is a serious problem for the cosmetic industry , since truly hypoallergenic preservatives are not available but products such as moist sanitary wipes in large packages definitely require some form of protection .',
  'Food allergy is a serious food safety problem worldwide , and the investigation of food allergens is the foundation of preventing and treating them , but relevant knowledge is far from sufficient .',
  'Food allergies are a serious and rising public health concern .',
  'Food allergy is a serious problem for infants and young children .',
  'Latex allergy confounded by IV infiltration presents a serious problem for pediatric patients .',
  'However , having a chronic disease like a severe allergy may add stress and challenges beyond normal development and involves a struggle between adapting socially , feeling healthy , and managing the disease .',
  'Allergic disease is a serious problem in practical healthcare .',
  'Although food allergy is a serious health problem in westernized countries , factors influencing the development of food allergy are largely unknown .',
  'Given that during OIT an allergic patient ingests an allergen that could potentially cause a serious reaction , the safety of OIT is of particular concern .',
  'However , peanuts is among the " big eight food allergens " , and allergies induced by peanuts are a significant public health problem and a life-threatening concern .',
  'Allergy to short ragweed ( Ambrosia artemisiifolia ) pollen is a serious and expanding health problem in North America and Europe .',
  'Allergic reactions to drugs are a serious public health concern .',
  'Pediatric food allergy is a serious health problem in the United States .',
  'Although latex products have been in use for over a century , allergic responses to latex proteins have only been recognized as a serious health problem for the past 15 years .',
  'Over the last ten years allergy to latex has become a serious , life-threatening medical problem .',
  'Latex allergy is a serious problem for health care providers and the general public .',
  'Medical devices manufactured from latex pose a serious problem because of the risk of induction of allergy both against the latex proteins inherently present ( type I or immediate type allergy ) and against chemicals added during processing ( type IV or delayed type hypersensitivity ) present as residues in the latex products .',
  'Changes in complement and coagulation factors in a patient suffering a severe anaphylactoid reaction to injected contrast material : some considerations of pathogenesis .',
  'Allergy to latex has become a serious and increasingly common health problem , particularly for healthcare workers and patients who undergo frequent surgical procedures .',
  'Type I allergy represents a severe health problem in industrialized countries where up to 20 % of the population suffers from allergic rhinitis , conjunctivitis and allergic asthma bronchiale and in severe cases from anaphylaxis , leading to death .',
  'Food allergy is a serious public health problem in Canada and other high-income countries , as it is potentially life threatening and severely impacts the quality of life for individuals and their families .',
  'Childhood allergies are a serious problem , as they may lead to lifetime chronic disease .',
  'In conclusion , the present study shows that anaphylaxis represents a serious and relevant medical problem in the pediatric population and should be ever carefully managed .',
  'Food allergy is a serious health problem for which a validated outbred large animal model would be useful in comparative investigations of immunopathogenesis and treatment and in testing hypotheses relevant to complex host-environmental interactions in predisposition to and expression of food allergy .',
  'Mouse allergy in both laboratory workers and in inner-city children is associated with allergic rhinitis and asthma , posing a serious public health concern .',
  'In the past decade , immediate hypersensitivity to latex has been accepted as a serious problem .',
  'Allergic reactions to peanuts are a serious health problem because of their high prevalence , associated with potential severity , and chronicity .',
  'Childhood food allergy is a serious health problem .',
  'The prevalence of self-reported doctor-diagnosed food allergy among US adults is 5.3 % , and a large portion of adults with food allergy found certain label issues a serious problem for managing their food allergy .',
  'Although anaphylaxis continues to be recognized as a life-threatening clinical problem , efforts to develop in-vitro methods for diagnosis and verification continue .',
  'Food allergy is a serious health concern among infants and young children .',
  'Latex allergy is recognized as a serious health problem among health care workers and children with spina bifida .',
  'Fruit allergies have become more common in recent years , and are now a serious health problem .',
  'Food allergy ( FA ) is a serious health problem , and its incidence has been increasing especially in children .',
  'Allergies to various inhalative allergens are a serious problem in the bakery and confectionery industry .',
  'Food allergy has become a serious health concern especially in developed countries in the past two decades .',
  'One patient with a fatal outcome was initially diagnosed as allergic alveolitis rather than infection and received steroid treatment illustrating the obvious challenges in the differential diagnosis between these disease entities .',
  'This study demonstrated that artisanal cashew nut roasting is a serious occupational problem , with harmful effects on workers׳ health .',
  ': Allergy is a serious problem affecting approximately 1 of 4 individuals .',
  "Baker 's asthma , a typical occupational allergic disease , is a serious problem in the food industries .",
  'Although relatively infrequent , meat allergy represents a serious problem for children both because it is generally associated with intolerance to other protein sources and because of the suggested role of meat in stimulating the gastrointestinal development during weaning .',
  'Cereal-associated allergy is particularly considered a serious problem , because cereals are essential in our daily diet .',
  'Occupational dermatoses represent a serious problem , especially the development of an allergy to constituents of the resin-based filling materials and adhesives .',
  'In conclusion , the present study shows that anaphylaxis represents a serious and relevant medical problem in the general population at any age , and should always be carefully managed .',
  'Natural rubber latex allergy is a serious medical problem for a growing number of patients and a disabling occupational disease among health care workers .',
  'Cashew and pistachio allergies are considered a serious health problem .',
  'Since wheat allergy is considered a serious problem globally , it is significant to examine the allergenicity of soy sauce .',
  'From our experience we conclude that dextran-induced anaphylactoid reactions are still a serious problem despite immunoprophylaxis .',
  'IgE-mediated allergic reactions to egg white are a serious health problem and ovomucoid being the dominant egg white allergen has been on focus in the past decade .',
  'Allergic diseases represent a serious public health problem all over the world , and they use to be associated with environmental factors as well as with each patient genetic predisposition .',
  'Natural latex gloves are the cause of a severe health problem to an increasing number of healthcare workers or patients due to the presence of protein allergens as Hevein or Rubber Elongation Factor ( REF ) .',
  'Latex allergy currently constitutes a serious problem because of the severity of its symptoms and the at-risk groups it affects .',
  'As for the methodologies for the detection of allergens in foods , this issue is a serious problem for both the food industry and control laboratories .',
  'Food allergy ( FA ) is a serious , costly and growing health problem worldwide .',
  'Food allergy is a serious problem affecting a growing number of children worldwide .',
  'However , IgE-mediated immediate reactions to latex have become a serious concern for health care workers ( HCWs ) .',
  'Food allergy ( FA ) is a serious health problem , and severe FA such as food-induced anaphylaxis can often be life threatening .',
  "Latex allergy may not be as prevalent as we think , but it 's still a serious problem that affects patients and healthcare workers alike . You can minimize its effects by knowing who 's at risk , how it 's diagnosed , and how to reduce the amount of latex in your workplace .",
  'Latex allergy is a serious medical problem for an increasing number of patients and health care workers .',
  'Increasing frequencies of sensitization to the fragrance mix ( FM ) have been acknowledged as a serious problem for many years .',
  'Wrong concepts related to anaphylaxis treatment are frequently observed and this is a serious problem since GPs are the front-line doctors in the management of out-patient anaphylactic reactions and therefore it is absolutely mandatory that they can be able not only to accurately diagnose and treat an acute anaphylactic episode but also to make a correct retrospective diagnosis and to advise on the use of epinephrine auto-injectors .',
  'Anaphylaxis is a life-threatening , systemic allergic reaction that presents unique challenges for emergency care practitioners .',
  'Heparin-induced IgE-mediated hypersensitivity and anaphylactoid reactions , although rare , can pose a serious clinical problem for patients requiring cardiopulmonary bypass ( CPB ) .',
  'Food allergy is a serious and potentially life-threatening problem for an estimated 6 % of children and 3.7 % of adults .',
  'The prevalence of atopic allergy to Poaceae grasses poses a serious health problem .',
  'Laboratory animal allergy is a serious health problem .',
  'Anaphylaxis is a severe life-threatening systemic reaction that offers many challenges to the clinician .',
  'Perioperative anaphylactic shock is a serious problem due to the difficulty of judgment and potentially disastrous outcome .',
  'Hidden allergens in food products are , especially for peanut-allergic consumers , a serious problem because even low amounts ( approximately 200 microg ) of peanut can elicit allergic reactions .',
  'Food allergy is a serious public health problem with an increasing prevalence .',
  'Regarding attitudes , most ( 94 % ) felt food allergy is a serious health problem , for which schools should have guidelines ( 94 % ) .',
  'Allergy prevention remains a vexing problem .'],
 'allergies': ["Prevalence and severity of cow's milk protein allergy (CMA) in infants are increasing.",
  'Cow milk allergy (CMA) is the most common food allergy in breastfed infants.',
  'Food allergy (FA) is a prevalent condition in the United States, but little is known about its phenotypes in racial minority groups',
  'A major drawback of oral immunotherapy for food allergy is the possibility of severe side-effects .',
  'A major drawback of oral tolerance ( OT ) induction protocols , however , is the possibility of severe side effects ; thus , we have formulated a hypoallergenic egg product and demonstrate its in vivo capacity to modulate the immune system in the current study .',
  'Food allergy is a serious and growing problem .',
  'The presence of species-specific proteins , different from those declared in label , may be a serious problem for people with allergies .',
  'Food allergies represent a serious problem affecting human health and soy proteins rank among the most allergenic proteins from food origin .',
  'Many tree nuts are considered to be a serious problem in food safety , because of the presence of causative factors in IgE-mediated food allergies .',
  'Food allergy is a serious food safety problem worldwide , and the investigation of food allergens is the foundation of preventing and treating them , but relevant knowledge is far from sufficient .',
  'Food allergies are a serious and rising public health concern .',
  'Food allergy is a serious problem for infants and young children .',
  'Although food allergy is a serious health problem in westernized countries , factors influencing the development of food allergy are largely unknown .',
  'However , peanuts is among the " big eight food allergens " , and allergies induced by peanuts are a significant public health problem and a life-threatening concern .',
  'Pediatric food allergy is a serious health problem in the United States .',
  'Food allergy is a serious public health problem in Canada and other high-income countries , as it is potentially life threatening and severely impacts the quality of life for individuals and their families .',
  'Food allergy is a serious health problem for which a validated outbred large animal model would be useful in comparative investigations of immunopathogenesis and treatment and in testing hypotheses relevant to complex host-environmental interactions in predisposition to and expression of food allergy .',
  'Allergic reactions to peanuts are a serious health problem because of their high prevalence , associated with potential severity , and chronicity .',
  'Childhood food allergy is a serious health problem .',
  'The prevalence of self-reported doctor-diagnosed food allergy among US adults is 5.3 % , and a large portion of adults with food allergy found certain label issues a serious problem for managing their food allergy .',
  'Food allergy is a serious health concern among infants and young children .',
  'Fruit allergies have become more common in recent years , and are now a serious health problem .',
  'Food allergy ( FA ) is a serious health problem , and its incidence has been increasing especially in children .',
  'Allergies to various inhalative allergens are a serious problem in the bakery and confectionery industry .',
  'Food allergy has become a serious health concern especially in developed countries in the past two decades .',
  'This study demonstrated that artisanal cashew nut roasting is a serious occupational problem , with harmful effects on workers׳ health .',
  "Baker 's asthma , a typical occupational allergic disease , is a serious problem in the food industries .",
  'Although relatively infrequent , meat allergy represents a serious problem for children both because it is generally associated with intolerance to other protein sources and because of the suggested role of meat in stimulating the gastrointestinal development during weaning .',
  'Cereal-associated allergy is particularly considered a serious problem , because cereals are essential in our daily diet .',
  'Cashew and pistachio allergies are considered a serious health problem .',
  'Since wheat allergy is considered a serious problem globally , it is significant to examine the allergenicity of soy sauce .',
  'IgE-mediated allergic reactions to egg white are a serious health problem and ovomucoid being the dominant egg white allergen has been on focus in the past decade .',
  'As for the methodologies for the detection of allergens in foods , this issue is a serious problem for both the food industry and control laboratories .',
  'Food allergy ( FA ) is a serious , costly and growing health problem worldwide .',
  'Food allergy is a serious problem affecting a growing number of children worldwide .',
  'Food allergy ( FA ) is a serious health problem , and severe FA such as food-induced anaphylaxis can often be life threatening .',
  'Food allergy is a serious and potentially life-threatening problem for an estimated 6 % of children and 3.7 % of adults .',
  'The prevalence of atopic allergy to Poaceae grasses poses a serious health problem .',
  'Laboratory animal allergy is a serious health problem .',
  'Hidden allergens in food products are , especially for peanut-allergic consumers , a serious problem because even low amounts ( approximately 200 microg ) of peanut can elicit allergic reactions .',
  'Food allergy is a serious public health problem with an increasing prevalence .',
  'Regarding attitudes , most ( 94 % ) felt food allergy is a serious health problem , for which schools should have guidelines ( 94 % ) .'],
 'tracheal': ['During cervical spine immobilization using Manual In Line Axial Stabilization (MILS), it is difficult to visualize the larynx by aligning the oropharyngeolaryngeal axes using Macintosh laryngoscope.',
  'Intraoperative contralateral pneumothorax during one-lung ventilation is a rare but life-threatening complication',
  'Pectus excavatum and carinatum are two of the most commonly observed chest wall deformities in pediatrics',
  'Acquired anterior glottic web poses a significant challenge to laryngologists given its propensity to recur following treatment, and there are a wide variety of described techniques',
  'Postoperative pulmonary complications (PPC) in patients with pulmonary diseases remain to be resolved clinical issue',
  'The pleating technique is widely used in plication but is difficult to perform with thoracoscopy because of its complex procedure and the limited surgical space',
  'A drawback of robotic lobectomy is the inability of the operating surgeon to perform stapler division of the pulmonary vessels and bronchi .',
  'Dilatation of the pulmonary autograft is a major drawback of the Ross procedure and it is the leading cause for reoperation in these patients .',
  'Increased TGF-β : a drawback of tracheal occlusion in human and experimental congenital diaphragmatic hernia ?',
  "HATS overcomes a major drawback of thoracoscopic surgery in allowing full manual palpation of the lungs via a subcostal ( mini-Kocher 's ) incision under videoscopic guidance , avoiding a thoracotomy , when the indication is pulmonary metastasectomy with curative intent or resection of undiagnosed lung nodules .",
  'In this study , the incidence of remnant lung lesions ( a drawback of segmentectomy ) was low .',
  'Recurrent inspiratory stridor , for which there appears to be no organic basis , can present a serious medical problem .',
  'Long-segment tracheal stenosis with complete tracheal rings is a severe and life-threatening problem in small children .',
  'Aspiration caused by unilateral combined laryngeal and pharyngeal paralysis is a serious clinical problem .',
  'Patients with Treacher Collins syndrome pose a serious problem to anaesthetists in maintaining their airway because of retrognathia .',
  'Nasopharyngeal stenosis in children is a serious problem .',
  'Lymphovenous Anastomosis for the Treatment of Chylothorax in Infants : A Novel Microsurgical Approach to a Devastating Problem : Correction .',
  'Insufficient intraopertive aerostasis is a serious , actual , and yet unsolved problem of pulmonary surgery .',
  'Tuberculous tracheobronchial stenosis is a serious clinical problem because it can cause obstructive pneumonia , dyspnea on exertion even pulmonary atelectasis of the whole lung .',
  'Bronchial stump insufficiency after pneumonectomy is a severe problem and there is still debate about the appropriate method ( transthoracic or transsternal ) for reclosure .',
  'Central airway obstruction ( CAO ) is a dangerous and increasingly common problem .',
  'Stenosis of the tracheobronchial tree can be a life-threatening problem .',
  'Florid and widespread respiratory papillomatosis is a devastating disorder in a subset of patients with recurrent respiratory papillomatosis , and it poses a major dilemma for the patient and the surgeon .',
  'Intractable aspiration is a life-threatening problem and often requires a procedure for blocking or separating the larynx from the bronchial tree .',
  'Elevation of right ventricular afterload associated with the decrease of pulmonary vascular bed is a serious problem immediately after pneumonectomy .',
  'Intractable aspiration is a life-threatening medical problem .',
  'Tracheal stenosis following prolonged intubation is a relatively rare but a serious problem .',
  'Poor secretion clearance is a serious problem for intubated patients leading to lung complications and delayed weaning .',
  'Pulmonary edema secondary to adenotonsillectomy is a serious surgical problem occurring in association with previous chronic , long-lasting obstructive complaints of the upper airway .',
  'Stenosis of the left main bronchus caused by inflammatory diseases and neoplasms is a serious clinical problem because it can cause obstructive pneumonia and may require pneumonectomy .',
  'Aspiration pneumonia is a life-threatening problem among patients with swallowing problems .',
  'Cricoid fracture is a serious concern for balloon dilatation in airway stenosis .',
  'The control of aerostasis after performing non-anatomical pulmonary resections constitutes a serious problem .',
  'Despite modern therapeutic procedures and the use of perfect materials tracheal stenosis is still a serious therapeutic problem .',
  'Lymphovenous Anastomosis for the Treatment of Chylothorax in Infants : A Novel Microsurgical Approach to a Devastating Problem .',
  'In 2 cases the malformation caused a severe functional restriction of lung volumes and surgery was performed to improve respiratory symptoms ; in other cases the symptoms were mild or absent and the malformation was a matter of concern only for cosmesis .',
  'Postoperative aspiration was the most frequent complication , but was a serious problem in only one patient .',
  'Alveolar air leakage remains a serious problem in lung surgery , being associated with increased postoperative morbidity , prolonged hospital stay and greater health-care costs .',
  'Management of the difficult pediatric airway is a serious problem that anesthesiologists face in their practice .',
  'Tracheal stenosis can be a life-threatening problem in children .',
  'Recurrent primary spontaneous pneumothorax ( PSP ) is a troublesome problem and a major concern for the patients .',
  'Intraoperative bronchospasm can be a life-threatening problem .',
  'It became a severe problem that the rate of recurrence after video-assisted thoracoscopic surgery ( VATS ) for spontaneous pneumothorax was higher than open surgery .',
  'Posttraumatic pneumothorax still remains to be a serious clinical problem and requires a comprehensive diagnostic and monitoring during treatment .',
  'Temporomandibular joint ankylosis presents a serious problem for airway management .',
  'Iatrogenic airway injury after tracheotomy and endotracheal intubation continues to be a serious clinical problem .',
  'Congenital tracheal stenosis was usually a serious problem often associated with other major anomalies of the respiratory tract , esophagus , or skeleton .',
  'Tracheobronchial stenosis , a serious problem in adults and children , has multiple causes and has been treated in many ways .',
  'Operative morbidity in patients with lung cancer associated with perioperative interstitial pneumonia ( IP ) has emerged as a serious problem .',
  'Although a rare complication , and despite technological improvements and better patient care in intensive care units , tracheal stenosis still constitutes a serious clinical problem which can also develop after a short period of mechanical ventilation .',
  'Post intubation long segment tracheal stenosis is a serious problem which usually requires multiple methods of treatment .',
  'Aspiration pneumonitis : a serious problem .',
  'Intractable aspiration may be a life-threatening problem for patients with altered laryngeal function secondary to neurologic disorders or abnormal laryngeal anatomy .',
  'Acute blunt laryngeal trauma can be a life-threatening event and often poses a difficult airway management problem .',
  'Primary spontaneous pneumothorax could be a serious therapeutic problem in case of recurrence .',
  'Pulmonary problems have been eliminated as primary cause of difficulties after reoperation , but infection remains a serious problem .',
  'Intractable aspiration is a life-threatening medical problem in patients with severe motor and intellectual disabilities ( SMID ) .',
  'BPF as well as residual intro-thoracic cavities after lobectomies pose a serious problem .',
  'Anesthetic management of a patient with deletion 8p syndrome may pose a serious problem mainly from difficult tracheal intubation , aspiration complication and cardiac malformation .',
  'Extensive tracheal defects may pose a life-threatening dilemma .',
  'Aspiration is a serious clinical concern in patients with long-term artificial airways .',
  'Aspiration ( the entry of foreign contents into the upper airway ) is a serious concern for individuals with dysphagia and can lead to pneumonia .',
  'Overall complication rates were similar , but there were two significant differences : ( 1 ) wound infection or dehiscence was a major problem in the traction intubation group , occurring in 23 % of the patients ; and ( 2 ) tube obstruction or displacement occurred more frequently in the pulsion intubation group ( 18.3 % versus 5.1 % ) but did not constitute a serious problem .',
  'Cricothyrotomy is the ultimate option for a patient with a life-threatening airway problem .',
  'Until tracheal replacement or better tolerated prosthetic or biologic supports are devised , tracheomalacia will remain a vexing problem complicating thyroidectomy for long-standing or recurrent airway-compressing goiter .',
  'Laryngeal dysfunction leading to incompetence and intractable aspiration can be a life-threatening problem .',
  'However , if airway resistance in the nose is high , large adenoids would present a serious airway problem and cause predominantly mouth breathing .',
  'Persistent air leak is a serious problem that may cause empyema , hypoxia , respiratory insufficiency , and other life-threatening complications .'],
 'sexual': ['Elevated prolactin levels were found to be associated with impaired sexuality.',
  'A recurring problem with the study of sexual fantasy is that of social desirability bias .',
  "The problem with the term is that it is not specific enough and does not allow for proper discussion of the very important problem of pain with sexual intercourse , a problem that can be very disturbing to a couple 's relationship .",
  'One problem with most physician and patient surveys is that they have been performed retrospectively , and pretreatment impotence and incontinence prevalent in older men can not be assessed accurately in retrospective studies .',
  'It is important to realize that over half the patients presenting with unilateral cryptorchidism and the majority of those presenting with bilateral cryptorchidism have abnormal spermiogram which indicates that unilateral cryptorchidism is in fact a bilateral disease and therefore a serious andrological problem .',
  'Odds of reporting a distressing sexual problem decreased over time for female but not male adolescents .',
  'Over half of patients with unilateral cryptorchidism and the majority of patients with bilateral cryptorchidism display an abnormal spermiogram , which indicates that unilateral cryptorchidism is a bilateral disease ; therefore , it represents a serious andrological problem .',
  'Erectile dysfunction ( ED ) is a serious public health problem that has a high prevalence and negatively affects the quality of life in elderly men .',
  'Erectile dysfunction and quality of life in type 2 diabetic patients : a serious problem too often overlooked .',
  'Thus , sexual frigidity coupled with dyspareunia was usually a serious problem faced by postoperative patients .',
  'Erectile dysfunction ( ED ) is often perceived by both patients and sexual partners as a serious problem that can jeopardize quality of life , psychosocial or emotional well-being , and the partnership in the long term .',
  'One in 10 young people experiences a distressing sexual problem .',
  "Sexual dysfunction is currently considered a serious quality-of-life-related health problem , exerting a major impact on patients ' and their sexual partners ' life .",
  'Inability to have a satisfactory sexual intercourse is a serious problem affecting many people .',
  'Just less than one third of participants ( n \xa0 = 61 , 30.3 % ) reported that sex had changed for the worse since their cardiac event or diagnosis , with approximately half of these stating that this was a serious problem for them .',
  'Twenty-three per cent reported that sex had deteriorated for them since their cardiac event , and for half of these this was considered a serious problem .',
  'Sexual dysfunction is a serious problem worldwide .',
  "Sexual dysfunction is a serious public health problem that affects women 's quality of life .",
  'Absence of the vagina is a distressing problem .',
  "Finally , my doctor gave me a prescription for Desyrel , and he seems to have hit the bull's-eye . I 've been sleeping much better and have n't noticed any side effects . But my pharmacist warned me about abnormal erections . Is it a serious concern ?",
  'For males , erectile dysfunction and retrograde ejaculation are well known complications of the disease In addition , the risk of transferring a fatal disease to their offspring is a matter of concern for the patients .',
  'This case report illustrates how a serious identity problem is crucial in dynamically understanding this rare sexual dysfunction .',
  'Cryptorchidism is a serious problem , which affects 2 - 5 % of the male population .',
  'Impotence is a distressing problem with a number of causes .',
  'Neovaginal atresia especially following male-to-female transgender vaginoplasty is a distressing concern .',
  'Persistent sexual dysfunction and depression in finasteride users for male pattern hair loss : a serious concern or red herring ?',
  'Up to half of sexually active older women report a distressing sexual problem , with low desire and problems related to genitourinary syndrome ( vulvovaginal atrophy ) being most common .',
  'As erectile dysfunction is a serious matter of concern and there are no data explaining this observation sufficiently , the purpose of this study was to revaluate the erectile function in patients after TJA .',
  'Erectile dysfunction ( ED ) is a distressing problem in hemodialysis patients .',
  'Severe hypertension during electro-ejaculation is a serious problem in patients with high lesions and is probably part of the syndrome of autonomic dysreflexia .',
  'Among sexually active 16- to 21-year-old participants , 9.1 % of men and 13.4 % of women reported a distressing sexual problem lasting 3 months or more in the last year .',
  'ED was perceived as a serious problem associated with loss of manhood and it had a significant impact on relationships with their partners .',
  'First , we present the context in which hypoactive sexual desire disorder is defined as a serious medical condition , showing how non-medical and non-scientific influences shaped the understanding of the problem .',
  'Until 50 years ago , sexual dysfunction was not regarded as a serious medical problem which is directly responsible for scarce or limited clinical data available on the topic nowadays .',
  'Loss of length in men with PD remains a serious concern .',
  'Globally , female sexual dysfunction is a serious concern based on negative family and social consequences , high side effects of medications and lack of effective treatment .',
  "Vaginismus is a severe dysfunction and a problem which can interfere with woman 's and couple 's sex life .",
  'Social isolation was a serious problem , with lack of opportunity for sexual contacts only partly related to restricted mobility .',
  "We defined ' ED ' as a report of erections with ' reduced rigidity ' or worse ; ' Significant_ED ' as ' severely reduced rigidity ' or ' no erections ' ; and ' Clinically_Relevant_ED ' as either ' ED ' reported as ' quite a problem ' or ' a serious problem ' , or ' Significant_ED ' reported as at least ' a bit of a problem ' .",
  'The findings from this study suggest that a lack of public health information about dyspareunia and the reluctance of health care providers to inquire about sexual problems may contribute to many young women delaying treatment for a serious sexual health problem with potentially negative biopsychosocial outcomes .',
  'Sexual morbidity is a distressing and undertreated problem in gynecological cancer survivorship known to occur early and persist well beyond the period of physical recovery .',
  'Approximately half of participants agreed or strongly agreed that BED is a serious problem ( male : 52.0 % ; female : 63.2 % ) requiring professional treatment ( male : 48.2 % ; female : 54.5 % ) .',
  'Erectile dysfunction ( ED ) associated with type 2 diabetes is a severe problem that requires effective treatment .',
  'Male sexual dysfunction is a serious problem which has an impact on the quality of life .',
  "I have an embarrassing problem . Over the past year or so , my erections seem to have become crooked . My sex life is fine , but I want to know if it 's a serious problem and if I should see a doctor .",
  'Men in general did not recognize DVAW as a serious social problem ; noticeably , they saw it as a personal and family issue .',
  'It is secondary to several organic , psychogenic , and combined causes , and represents a serious health dilemma affecting both men and their partners .'],
 'spinal': ['Thoracolumbar fractures are among the most common types of damages caused to the spinal cord .',
  'Lumbar spinal stenosis is a common diagnosis in elderly individuals, and the rates of surgery have risen all over the world.',
  'Pediatric spinal trauma is rare and challenging entity',
  'A major drawback of currently available spinal cord stimulation ( SCS ) systems for the management of chronic intractable pain , especially of widespread pain patterns as in reflex sympathetic dystrophy , is the generally limited paresthesia coverage .',
  'Spinal cord injury ( SCI ) is a serious medical problem with high mortality and disability rates .',
  'Spinal cord injury ( SCI ) is a serious clinical problem that suddenly deprives patients of neurologic function and drastically diminishes their quality of life .',
  'Spinal cord injury ( SCI ) is a severe health problem and the mechanism involved remains elusive .',
  'Spinal cord injury is a serious problem with a high rate of morbidity and mortality for all persons , especially young people ( 15 - 25 \xa0 years old ) .',
  'Traumatic spinal cord injury remains a serious public health and social problem .',
  'Lumbar disc degeneration ( LDD ) is a serious social and medical problem which has been shown to be highly heritable .',
  'Spinal cord injury ( SCI ) is a severe health problem worldwide , and efficacious strategies to properly repair SCI have not yet been developed .',
  'Spinal cord injury ( SCI ) is a serious problem that primarily affects younger and middle-aged adults at its onset .',
  'Scoliosis is a serious clinical problem which requires a systematic physical therapy and control of body balance -- treatment from the moment of achieving skeletal maturity by a child .',
  'Spinal cord injury is a devastating health problem that affects thousands of individuals each year .',
  'Successful treatment of lumbar disc herniation constitutes a serious interdisciplinary problem .',
  'A spinal cord injury is a devastating , life-changing neurologic event that challenges patients , families , and caregivers .',
  'Low back pain after either post lumbar surgery syndrome or spinal stenosis in the absence of surgery is a vexing problem .',
  'Acute spinal cord injury is a serious concern in football , particularly the rugby codes .',
  'Spinal cord injuries are still a serious problem for regenerative medicine .',
  'Intervertebral disc degeneration ( IDD ) is thought to be the primary cause of low back pain , a severe public health problem worldwide .',
  'Spinal Cord Injury ( SCI ) is a devastating health problem both for the patient and the clinician .',
  'Spinal cord damage caused by ischemia is a serious , underappreciated , and relatively refractory problem in clinical practice .',
  'Degenerative disc disease in the lumbar spine is a serious health problem .',
  'Spinal cord injury represents a serious medical problem , and leads to chronic conditions that can not be reversed at present .',
  'Spinal cord injury ( SCI ) is a devastating problem of health .',
  'Spinal deformity is frequently progressive and can add a serious problem to the complicated disease with its already high morbidity and mortality .',
  'Spinal cord injury ( SCI ) is a severe medical problem leading to crucial life change .',
  'Scoliosis is a serious clinical problem which requires a systematic physical therapy and control of body balance - treatment from the moment of achieving skeletal maturity by a child .',
  'Autonomic dysreflexia is a serious problem in patients with spinal cord lesions above the fifth thoracic level .',
  "Spinal cord injury is a serious problem that affects many facets of an individual 's life .",
  'Spinal cord injury ( SCI ) is a serious medical problem , leading to lifelong disability and increasing the health burden worldwide .',
  'Spinal cord injuries ( SCI ) have been reckoned for many years a serious clinical problem .',
  'Spinal cord injury is a severe clinical problem , and research searching activity molecular that can promote spinal cord injury repairing is very prevalent .',
  'Spinal cord injury ( SCI ) is a serious global problem that leads to permanent motor and sensory deficits .',
  'To our knowledge , this is the first time a severe heart conduction problem was induced in a spinal cord injury patient after a single therapeutic dose of Baclofen .',
  'Affecting young people during the most productive period of their lives , spinal cord injury ( SCI ) is a devastating problem for modern society .',
  'A plea is made for those involved in the management of spinal cord injury patients ( irrespective of specialty ) to be aware that autonomic dysreflexia can be a life-threatening problem if not promptly recognized and appropriately treated .',
  'Spinal disease due to intervertebral disc degeneration represents a serious medical problem which affects many people worldwide .',
  'Spinal cord injury ( SCI ) represents a severe health problem worldwide usually associated with severe disability and reduced quality of life .',
  'Traumatic spinal cord injury ( TSCI ) is a devastating problem typically associated with multi-organ disorders .',
  'Spinal trauma is a serious problem of modern medicine .',
  'Spinal cord injury ( SCI ) is a severe clinical problem worldwide .',
  'Spinal cord injury is a serious global public health problem that often leaves patients with devastating permanent disabilities .',
  'Acute spinal cord injury ( SCI ) is a devastating problem , with over 10,000 new cases annually .',
  'Spine pain is a serious clinical problem of physically active people and sportplayers .',
  'By affecting young people during the most productive period of their lives , spinal cord injury is a devastating problem for modern society .',
  'Spinal cord injury ( SCI ) , a severe health problem in worldwide , was commonly associated with functional disability and reduced quality of life .',
  'Spinal cord injury ( SCI ) is a severe health problem worldwide .',
  'Spinal cord injury ( SCI ) is a serious clinical problem for which no suitable therapeutic strategies have been worked out so far .',
  'Classic degenerative disc disease is a serious health problem worldwide , whose etiological basis-mechanical stimulus , biochemical changes , or natural aging-is poorly understood .',
  'Spinal cord injury is a serious disabling disease caused by a series of internal and external factors in the field of orthopaedics and neuroscience , which is a big problem for doctors all over the world .',
  'Spinal cord injury ( SCI ) is a serious clinical problem that causes lifetime disabilities to victims and inflicting huge social burden on our society .',
  'As KBD may be linked with chronic pain and a decrease in mobility , it is a serious welfare problem .',
  'Intervertebral disc degeneration ( IDD ) is a serious health problem worldwide .',
  'Degenerative spine disease is a serious social problem .',
  'Spinal cord injuries continue to be a devastating medical problem .',
  'Spinal cord ischemia after treatment of thoracic pathologies remains a devastating problem .',
  'Pain management is a serious problem for individuals with spinal cord injury ( SCI ) .',
  'SUMMARY \xa0 Persistent neuropathic pain after spinal cord injury ( SCI ) is a serious problem that significantly affects general health and wellbeing over and above what is caused by other medical consequences after SCI .'],
 'injury': ['Thoracolumbar fractures are among the most common types of damages caused to the spinal cord .',
  'Pediatric spinal trauma is rare and challenging entity',
  'A major drawback of currently available spinal cord stimulation ( SCS ) systems for the management of chronic intractable pain , especially of widespread pain patterns as in reflex sympathetic dystrophy , is the generally limited paresthesia coverage .',
  'Acute kidney injury ( AKI ) is a serious problem in critically ill patients of intensive care units .',
  'Spinal cord injury ( SCI ) is a serious medical problem with high mortality and disability rates .',
  'Spinal cord injury ( SCI ) is a serious clinical problem that suddenly deprives patients of neurologic function and drastically diminishes their quality of life .',
  'Acute kidney injury ( AKI ) remains a serious clinical problem in the intensive care unit ( ICU ) .',
  'Spinal cord injury ( SCI ) is a severe health problem and the mechanism involved remains elusive .',
  'Spinal cord injury is a serious problem with a high rate of morbidity and mortality for all persons , especially young people ( 15 - 25 \xa0 years old ) .',
  'Traumatic spinal cord injury remains a serious public health and social problem .',
  'Spinal cord injury ( SCI ) is a severe health problem worldwide , and efficacious strategies to properly repair SCI have not yet been developed .',
  'DIN accounts for 18 - 27 % of community- and hospital-acquired episodes of acute kidney injury ( AKI ) and is a serious concern during development of novel therapeutic drugs .',
  'Acute kidney injury is a serious global health problem and determinant of morbidity and mortality .',
  'Spinal cord injury ( SCI ) is a serious problem that primarily affects younger and middle-aged adults at its onset .',
  'Scoliosis is a serious clinical problem which requires a systematic physical therapy and control of body balance -- treatment from the moment of achieving skeletal maturity by a child .',
  'Acute kidney injury ( AKI ) is a serious clinical problem with high morbidity and mortality .',
  'Ischemic acute kidney injury ( AKI ) is a serious clinical problem and no efficient therapeutics is available in clinic now .',
  'Acute kidney injury ( AKI ) is a serious clinical problem with high rate of mortality and morbidity .',
  'Spinal cord injury is a devastating health problem that affects thousands of individuals each year .',
  'Acute kidney injury ( AKI ) is a severe and preventable problem of crushed earthquake victims .',
  'A spinal cord injury is a devastating , life-changing neurologic event that challenges patients , families , and caregivers .',
  'Acute spinal cord injury is a serious concern in football , particularly the rugby codes .',
  'Spinal cord injuries are still a serious problem for regenerative medicine .',
  'Acute kidney injury is a serious public health problem , especially in intensive care units , where patients may require dialysis support , resulting in 50 % mortality .',
  'Spinal Cord Injury ( SCI ) is a devastating health problem both for the patient and the clinician .',
  'Renal involvement can be a serious problem for patients with antiphospholipid syndrome ( APS ) .',
  'Spinal cord damage caused by ischemia is a serious , underappreciated , and relatively refractory problem in clinical practice .',
  'Acute kidney injury following cardiac surgery depicts a severe clinical problem that is strongly associated with adverse short- and long-term outcome .',
  'Acute kidney injury ( AKI ) is a serious global public health problem .',
  'Spinal cord injury represents a serious medical problem , and leads to chronic conditions that can not be reversed at present .',
  'Spinal cord injury ( SCI ) is a devastating problem of health .',
  'Spinal deformity is frequently progressive and can add a serious problem to the complicated disease with its already high morbidity and mortality .',
  'Spinal cord injury ( SCI ) is a severe medical problem leading to crucial life change .',
  'The occurrence of non-function in one half of a horseshoe kidney resulting from hydronephrosis can , if unrecognized , create a serious surgical as well as medical problem .',
  'Acute kidney injury ( AKI ) is a serious and common problem that is associated with high mortality .',
  'Acute renal failure ( ARF ) remains a serious medical problem with a high mortality rate .',
  'Acute kidney injury ( AKI ) constitutes a serious public health problem because of its very high cost and mortality rate , with an increasing incidence , phenomenon which is explained by the increasingly number of older patients suffering from several comorbidities admitted in the intensive care units .',
  'Renal failure after bypass is still a threatening problem prolonging hospital care and reducing overall survival .',
  'In fact , drug-induced kidney injury is a serious problem in clinical practice and accounts for roughly 20 % of cases of acute kidney injury ( AKI ) among hospitalized patients .',
  'Autonomic dysreflexia is a serious problem in patients with spinal cord lesions above the fifth thoracic level .',
  'Acute kidney injury ( AKI ) is a serious problem .',
  "Spinal cord injury is a serious problem that affects many facets of an individual 's life .",
  'Spinal cord injury ( SCI ) is a serious medical problem , leading to lifelong disability and increasing the health burden worldwide .',
  'Spinal cord injuries ( SCI ) have been reckoned for many years a serious clinical problem .',
  'Spinal cord injury is a severe clinical problem , and research searching activity molecular that can promote spinal cord injury repairing is very prevalent .',
  'Acute kidney injury ( AKI ) is a devastating clinical problem that affects a growing number of patients , especially elderly ones , and is associated with high morbidity and mortality .',
  'Spinal cord injury ( SCI ) is a serious global problem that leads to permanent motor and sensory deficits .',
  'To our knowledge , this is the first time a severe heart conduction problem was induced in a spinal cord injury patient after a single therapeutic dose of Baclofen .',
  'In critically ill patients , acute kidney injury ( AKI ) is a devastating problem often associated with adverse outcomes .',
  'Affecting young people during the most productive period of their lives , spinal cord injury ( SCI ) is a devastating problem for modern society .',
  'Acute Renal Failure ( ARF ) is the most costly kidney disease in hospitalized patients and remains as a serious problem in clinical medicine .',
  'A plea is made for those involved in the management of spinal cord injury patients ( irrespective of specialty ) to be aware that autonomic dysreflexia can be a life-threatening problem if not promptly recognized and appropriately treated .',
  'Acute kidney injury following cardiac surgery is a serious problem among patients in eastern Saudi Arabia .',
  'Spinal cord injury ( SCI ) represents a severe health problem worldwide usually associated with severe disability and reduced quality of life .',
  'Traumatic spinal cord injury ( TSCI ) is a devastating problem typically associated with multi-organ disorders .',
  'Spinal trauma is a serious problem of modern medicine .',
  'Acute renal failure presents a serious and life-threatening problem in hospitalized patients .',
  'Spinal cord injury ( SCI ) is a severe clinical problem worldwide .',
  'Spinal cord injury is a serious global public health problem that often leaves patients with devastating permanent disabilities .',
  'Acute spinal cord injury ( SCI ) is a devastating problem , with over 10,000 new cases annually .',
  'Acute kidney injury remains a serious clinical problem for intensive care unit patients , and its incidence is rising .',
  'Acute kidney injury ( AKI ) remains a vexing clinical problem that results in unacceptably high patient mortality , development of chronic kidney disease , and accelerated progression to end-stage kidney disease .',
  'By affecting young people during the most productive period of their lives , spinal cord injury is a devastating problem for modern society .',
  'Spinal cord injury ( SCI ) , a severe health problem in worldwide , was commonly associated with functional disability and reduced quality of life .',
  'Spinal cord injury ( SCI ) is a severe health problem worldwide .',
  'Spinal cord injury ( SCI ) is a serious clinical problem for which no suitable therapeutic strategies have been worked out so far .',
  'Spinal cord injury is a serious disabling disease caused by a series of internal and external factors in the field of orthopaedics and neuroscience , which is a big problem for doctors all over the world .',
  'Spinal cord injury ( SCI ) is a serious clinical problem that causes lifetime disabilities to victims and inflicting huge social burden on our society .',
  'Acute kidney injury ( AKI ) can be a devastating problem for hospitalized patients .',
  'Acute kidney injury in the context of nephrotic syndrome is a serious and alarming clinical problem .',
  'Spinal cord injuries continue to be a devastating medical problem .',
  'Acute kidney injury ( AKI ) is a serious problem occurring in anywhere between 8 and 30 % of children in the intensive care unit .',
  'Spinal cord ischemia after treatment of thoracic pathologies remains a devastating problem .',
  'Pain management is a serious problem for individuals with spinal cord injury ( SCI ) .',
  'SUMMARY \xa0 Persistent neuropathic pain after spinal cord injury ( SCI ) is a serious problem that significantly affects general health and wellbeing over and above what is caused by other medical consequences after SCI .'],
 'meningitis': ['Meningitis is a life threatening central nervous system infection that is prevalent worldwide.',
  'Given its epidemic potential and development of severe forms of disease , viral meningitis ( VM ) is a serious public health problem .',
  'Meningitis remains a serious clinical problem in developing as well as developed countries .',
  'Bacterial meningitis is a life-threatening infection that remains a public health concern .',
  'Unusual presentation of primary amoebic meningoencephalitis -- a serious diagnostic and therapeutic problem .',
  'Post-traumatic meningitis is a dreadful condition that presents additional challenges , in terms of both diagnosis and management , when compared with community-acquired cases .',
  "In particular in the ' meningitis belt ' of sub-Saharan Africa , epidemic meningococcal meningitis is a severe public health problem .",
  'Despite the favourable clinical outcome in most cases , viral meningitis can cause a serious public health problem especially when several cases occur during outbreaks .',
  'Meningitis and/or encephalitis can pose a serious public health problem especially during outbreaks .',
  'Bacterial meningitis ( BM ) is a severe disease and still represents a serious public health problem with high rates of morbidity and mortality .',
  'Bacterial meningitis is a serious problem especially in preschool children .',
  'Drug-induced aseptic meningitis is a diagnosis of exclusion and presents a serious diagnostic dilemma .',
  'Even though usually associated with non-specific febrile illness , they are the most common cause of viral meningitis and pose a serious public-health problem , especially during outbreaks .',
  'Bacterial meningitis is a serious problem in pediatric clinics and , therefore , needs urgent and empirical chemotherapy .',
  'Neonatal meningitis is a serious problem with a high mortality and frequent neurological sequelae .',
  'Bacterial meningitis is a serious health concern worldwide .',
  'Meningitis is a serious problem in newborn infants and has high mortality and frequent neurological sequelae .',
  'Bacterial meningitis in children is a life-threatening problem resulting in severe morbidity and mortality .',
  'Although infection is usually asymptomatic , infections of the central nervous system manifested as meningitis or encephalitis can pose a serious public health problem , especially during outbreaks .',
  'Bacterial meningitis in the newborn and infant remains a serious problem , with a mortality rate of 24 % and a morbidity rate ranging from 30 to 50 % .'],
 'outbreaks': ['Meningitis is a life threatening central nervous system infection that is prevalent worldwide.',
  'Given its epidemic potential and development of severe forms of disease , viral meningitis ( VM ) is a serious public health problem .',
  'Meningitis remains a serious clinical problem in developing as well as developed countries .',
  'Bacterial meningitis is a life-threatening infection that remains a public health concern .',
  'Unusual presentation of primary amoebic meningoencephalitis -- a serious diagnostic and therapeutic problem .',
  'Post-traumatic meningitis is a dreadful condition that presents additional challenges , in terms of both diagnosis and management , when compared with community-acquired cases .',
  "In particular in the ' meningitis belt ' of sub-Saharan Africa , epidemic meningococcal meningitis is a severe public health problem .",
  'Despite the favourable clinical outcome in most cases , viral meningitis can cause a serious public health problem especially when several cases occur during outbreaks .',
  'Meningitis and/or encephalitis can pose a serious public health problem especially during outbreaks .',
  'Bacterial meningitis ( BM ) is a severe disease and still represents a serious public health problem with high rates of morbidity and mortality .',
  'Bacterial meningitis is a serious problem especially in preschool children .',
  'Drug-induced aseptic meningitis is a diagnosis of exclusion and presents a serious diagnostic dilemma .',
  'Even though usually associated with non-specific febrile illness , they are the most common cause of viral meningitis and pose a serious public-health problem , especially during outbreaks .',
  'Bacterial meningitis is a serious problem in pediatric clinics and , therefore , needs urgent and empirical chemotherapy .',
  'Neonatal meningitis is a serious problem with a high mortality and frequent neurological sequelae .',
  'Bacterial meningitis is a serious health concern worldwide .',
  'Meningitis is a serious problem in newborn infants and has high mortality and frequent neurological sequelae .',
  'Bacterial meningitis in children is a life-threatening problem resulting in severe morbidity and mortality .',
  'Although infection is usually asymptomatic , infections of the central nervous system manifested as meningitis or encephalitis can pose a serious public health problem , especially during outbreaks .',
  'Bacterial meningitis in the newborn and infant remains a serious problem , with a mortality rate of 24 % and a morbidity rate ranging from 30 to 50 % .'],
 'laparoscopic': ['Laparoscopy is difficult to master, in part because surgeons operate in a three-dimensional (3D) space guided by two-dimensional (2D) images.',
  'Laparoscopic incisional and ventral hernia repair (LIVHR) has been associated with a high incidence acute and chronic pain due to use of nonabsorbable tackers.',
  'The main problem with clinical introduction of laparoscopic techniques in urology is that despite experience with endoscopy no significant endoscopic training is given .',
  'One problem with this operation is that it leaves the bypassed segment of the gastrointestinal tract not readily available for either mechanical , radiological or endoscopic evaluation .',
  'Chronic postoperative pain is a major drawback of inguinal hernia repair .',
  'Though previous major abdominal surgery and pelvic irradiation may be a significant drawback of subsequent laparoscopic procedure , technological advances such as better visualization and more controlled finer movementsof robotic arms allowing better dissection in robotic-assisted laparoscopic surgery may reduce some of these challenges .',
  'Is There a Drawback of Converting a Laparoscopic Colectomy in Colon Cancer ?',
  'Standard bowel cleansing for colon capsule endoscopy ( CCE ) requires a liquid diet and bowel laxatives for at least 2 days , which is a major drawback of this procedure and affects tolerance and acceptability .',
  'On the other hand , the appearance of tumor implants in the port sites after laparoscopic resection for cancer is a significant drawback of this procedure .',
  'Conversion from laparoscopic to open appendicectomy : a possible drawback of the laparoscopic technique ?',
  'The need for stapling is a relative drawback of laparoscopic hernia repairs because it adds to the complications and costs .',
  'Prolonged operative time ( ORT ) is a drawback of laparoscopic bariatric surgery due to concerns for increased morbidity .',
  'A possible drawback of this operation is the difficult access to the excluded proximal intestinal tract and , consequently , to the biliary tract .',
  'Management of anastomotic leakage has become a serious concern for surgeons .',
  'The reported incidence of chronic pain in patients who underwent laparoscopic hernia repair is a serious problem .',
  'Large upper abdominal incisional hernias have always been a vexing problem to surgeons because of the rigidity of the costal arches .',
  'The surgical repair of giant hernias is a serious problem .',
  'A serious concern in applying laparoscopic surgery to malignancies is the possibility of tumor spillage and seeding .',
  'The retention of a capsule endoscope ( CE ) in the stomach and the duodenal bulb during the examination is a troublesome problem , which can make the medical staff spend several hours observing whether the CE enters the descending segment of the duodenum ( DSD ) .',
  'Parastomal hernia , particularly when recurrent , presents a troublesome problem to the surgeon .',
  'Reconstruction of massive abdominal wall defects has long been a vexing clinical problem .',
  'These two cases suggest that dehydration and electrolyte disturbance from high stomal output could be a serious problem following chemoradiation therapy in patients with an ileostomy .',
  'In the present situation , specially in a country like Ethiopia where long time care of internal drains is a worrisome problem , and a major point for concern , the author believes choledocho-enteric anastomosis to be a good solution .',
  'Major incisional hernias of the abdominal wall often pose a serious surgical problem .',
  'Internal hernias ( IH ) after Roux-en-Y gastric bypass ( RYGB ) are a serious concern among surgeons and are often under-diagnosed due to heterogeneity of clinical manifestations .',
  "Recurrence after laparoscopic ventral hernioplasty is a severe problem despite surgeons ' increased experience in recent years .",
  'Ventral/incisional abdominal hernias following celiotomies continue to be a vexing problem for both patients and general and plastic and reconstructive surgeons , since no universally applicable preventive or reconstructive techniques have evolved .',
  'Para-oesophageal hernia may be a serious problem with major complications .',
  'Despite refinements in the field of gastrointestinal surgical stapling , anastomotic leakage and bleeding still remain a serious problem associated with substantial morbidity and mortality .',
  'A common surgical procedure , ventral hernia repair has long been a vexing problem , with no clear standard for repair and significant postoperative morbidity .',
  'A serious problem may be leakage from bowel anastomoses .',
  'Anastomotic leakage remains a devastating problem for the patient , and a continuing challenge to the surgeon operating on high-risk areas of the gastrointestinal tract such as the esophagus and rectum .',
  'Incarcerated inguinal hernia in elderly patients is a serious problem .',
  'Postoperative hernia following bariatric procedures is more common than in other groups of surgical patients , and remains a serious problem .',
  'Considering its frequency , postoperative ventral hernia is a serious health problem .',
  'Chronic groin pain after inguinal hernia repair , a serious problem , is caused by entrapment of the ilioinguinal nerve either by mesh or development of fibrosis .',
  'Reactive hydrocele formation following laparoscopic varicocelectomy is a worrisome problem particularly in cases with longer follow-up .',
  'Buried BE may be a serious clinical problem since it can go unnoticed during surveillance endoscopies .',
  'Treatment of incarcerated abdominal hernia is a serious surgical problem .',
  'Anastomotic leaks developed in four patients , but only one of the leaks was considered a serious problem .',
  'The morbidity/mortality associated with ventral hernias continues to be a serious medical problem due to high rates of recurrence .',
  'Chronic groin pain after inguinal hernia repair ( IHR ) is a vexing problem .',
  'Incisional hernias still continue to be a serious problem for surgeons .',
  'Anastomotic leakage is a serious complication after colorectal surgery , and many risk factors for this problem have so far been identified .',
  'Anastomotic leakage is a serious problem in the laparoscopic resection of rectal cancer .',
  'Anastomotic leak after colorectal surgery , which remains a serious clinical problem that causes augmented morbidity and mortality , is usually favored by ischemia .',
  'Anastomotic leakage is a serious clinical problem after colorectal resections and is associated with a significantly increased length of stay , morbidity and mortality .',
  'Awareness of complications of colonic irrigation may be crucial for health care providers and parents to rapidly recognize a serious underlying problem .'],
 'opioid': ['The opioid crisis has led to increasing numbers of overdose fatalities in teens and young adults.',
  'One problem with the desensitization hypothesis is that acute morphine does not readily desensitize mu-opioid receptors in many cell types .',
  'A drawback of the immediate-release formulation of tramadol ( four-times-a-day dosing ) might be addressed by an extended-release formulation .',
  'The tensions surrounding methadone maintenance therapy ( MMT ) are outlined , as well as the sociohistorical context in which a serious heroin addiction problem in Ireland developed .',
  'Abuse , misuse , addiction , overdose , and death associated with non-medical use of prescription opioids have become a serious public health concern .',
  'Frequent use of opioid analgesics with other DIMs is a serious problem for drivers and increases the risk of accidents .',
  'Prescription opioid misuse and abuse is a serious public health concern that can lead to overdose , addiction , and death .',
  'Opioid addiction is a serious public health concern with severe health and social implications ; therefore , extensive therapeutic efforts are required to keep users drug free .',
  'A serious problem related to surgical care is persistent postoperative opioid use among previously opioid-naïve patients .',
  "Prescription opioid misuse in Canada has become a serious public health concern and has contributed to Canada 's opioid crisis .",
  'The combination of these proinflammatory factors reflects a devastating problem as opioids have high abuse liability and continue to be prescribed for certain patients experiencing HIV-1-related pain .',
  'Prescription opioid and heroin abuse have been increasing steadily year after year , and continue to be a serious national problem .',
  'Abuse of prescription opioid pain relievers continues to be a serious public health concern .',
  'Opioid dependence , a severe addictive disorder and major societal problem , has been demonstrated to be moderately heritable .',
  'Opioid use disorders are considered a serious public health problem among young adults .',
  'Misuse of opioid analgesics and other psychoactive medicines is a serious and increasing problem in Australia .',
  'Increased drug overdose deaths have become a serious public health problem .',
  'Prescription opioid abuse has become a serious national problem .',
  'The opioid epidemic is a severe problem in the world , especially in the United States , where prescription opioid overdose accounts for a quarter of drug overdose deaths .',
  'Opioid-related adverse events are a serious problem in hospitalized patients .',
  'Even originally introduced as efficient anesthetic drugs to relieve moderate-to-severe pain in clinic , the overdose of new synthetic opioids is currently a serious public health problem in numerous countries worldwide .',
  'The opioid epidemic has become a severe public health problem , with approximately 130 opioid-induced deaths occurring each day in the United States .',
  'The opioid epidemic continues to be a serious public health concern .',
  'Nonmedical use may lead to opioid abuse/dependence , a serious public health concern .',
  "Considering fentanyl 's high potency and abuse liability , the recent rise in fentanyl-related deaths is a serious public health concern and signifies the urgent need to establish prevention and treatment efforts .",
  'The high rates of HIV and Hepatitis C ( HCV ) infection among opioid abusers is a serious public health problem , and efforts to enhance knowledge regarding risks for HIV/hepatitis infection in this population are important .',
  'Nonmedical sedative use is emerging as a serious problem in India .',
  'The abuse of opioids is a serious and prevalent problem and research is needed on factors that may place individuals at risk for misusing opioids .',
  'Prescription opioid abuse and addiction , along with consequences such as overdose death and increasing transition to heroin use , constitute a devastating public health problem in the United States .',
  'Opioid use is a severe problem in Iran .',
  'Over the last two decades , opioid-related mortality rates have increased dramatically to become a serious public health concern in the United States .',
  'Opioid abuse is a serious public health concern .',
  'Oxycodone use disorder ( OUD ) is a serious health problem that has prompted a need to develop animal models of OUD that have both face and predictive validity .',
  'Morphine addiction is known as a serious social problem .',
  'Heroin dependence remains a serious and costly public health problem , even in patients receiving methadone maintenance treatment .',
  'Opioid use disorder is a serious public health problem .',
  'Opioid addiction to prescription and illicit drugs is a serious and growing problem .',
  'Prescription opioid misuse is a serious public health concern , yet antecedent factors are poorly described .',
  'Opioid use disorder is a serious international concern with limited treatment success .',
  'Misuse of opioid analgesics , in combination with diversion , dependence , and fatal overdoses , presents a serious problem for public health , which affects many countries worldwide .',
  'Opioid dependence is a serious worldwide health problem .',
  'Severe withdrawal signs which accompany the detoxification of narcotic addicts from opiate drugs are also a serious problem for chronic pain patients taking high levels of analgesic medications .',
  'Nonmedical prescription opioid use ( NMPOU ) is a serious public health problem in North America .',
  'With thousands of people in the United States dying of opioid overdose each month , the opioid epidemic has become a serious public health concern .',
  'However , several recent studies suggested that morphine induces apoptosis in human peripheral blood lymphocytes ( PBLs ) , raising a serious concern about the use of opioid-based analgesic strategies .',
  'Opioid-related respiratory depression ( RD ) is a serious clinical problem as it causes multiple deaths and anoxic brain injuries .',
  'Concomitant opioid abuse is a serious problem among patients receiving methadone maintenance treatment ( MMT ) for opioid use disorder .',
  'Opioid addiction , also referred to as opioid use disorder , continues to be a devastating problem throughout the world .',
  'The high level of prescribed sedative drug use reported by people receiving AOD treatment is a serious public health concern given the increasing incidence of drug overdose deaths in Australia .',
  'The current opioid crisis has created a tragic problem in medicine and society .',
  'Prescription opioid abuse and misuse are a serious problem in the U.S. today .',
  'Opioid addiction and overdose is a serious problem worldwide .',
  'Therefore , given the prevalence of opioid use and abuse , opioid-mediated immune suppression presents a serious concern in our society today .',
  'Opioid abuse is a devastating , costly , and growing problem in the United States , and one for which treatment can be complicated by barriers such as access to care and legal issues .',
  'Overdose is a serious problem as for people addicted to opioid drug injections ( ODI ) as well as for the community in general .',
  'Black participants and those who believed that illegal drug use was a serious problem had greater odds of locking opioids ; participants with higher levels of education or who knew someone who used heroin or misused prescription opioids had lesser odds of locking opioids .',
  'Prescription opioid abuse poses a serious problem in the United States , representing',
  'Continued illicit drug use by opioid-dependent patients maintained on methadone is a serious problem , undermining the goal of methadone maintenance treatment and increasing the risk for HIV .',
  'Opioid overdose was identified as a serious problem in the Richmond area and the United States by 71.9 % and 81.3 % of respondents , respectively .',
  'The comorbidity of chronic pain and opioid addiction is a serious problem that has been growing with the practice of prescribing opioids for chronic pain .',
  'Overdose from opioids is a serious public health and clinical concern . Veterans are at increased risk for opioid overdose compared with the civilian population , suggesting the need for enhanced efforts to address overdose prevention in Department of Veterans Affairs ( VA ) health care settings , such as primary care clinics .',
  'Although tramadol is thought to have low abuse and dependence potentials worldwide , its abuse has become a serious problem in many countries , particularly in the Middle East , Africa , and West Asia .',
  'Among opioid-dependent patients on maintenance therapy , concomitant drug abuse is a serious problem .',
  'Opioid abuse remains a serious public health problem .',
  'Opioid Use disorders are emerging as a serious public health concern in India .',
  'Opiate addiction is a serious problem that has now spread worldwide to all levels of society .'],
 'overdose': ['The opioid crisis has led to increasing numbers of overdose fatalities in teens and young adults.',
  'One problem with the desensitization hypothesis is that acute morphine does not readily desensitize mu-opioid receptors in many cell types .',
  'A drawback of the immediate-release formulation of tramadol ( four-times-a-day dosing ) might be addressed by an extended-release formulation .',
  'The tensions surrounding methadone maintenance therapy ( MMT ) are outlined , as well as the sociohistorical context in which a serious heroin addiction problem in Ireland developed .',
  'Abuse , misuse , addiction , overdose , and death associated with non-medical use of prescription opioids have become a serious public health concern .',
  'Frequent use of opioid analgesics with other DIMs is a serious problem for drivers and increases the risk of accidents .',
  'Prescription opioid misuse and abuse is a serious public health concern that can lead to overdose , addiction , and death .',
  'Opioid addiction is a serious public health concern with severe health and social implications ; therefore , extensive therapeutic efforts are required to keep users drug free .',
  'A serious problem related to surgical care is persistent postoperative opioid use among previously opioid-naïve patients .',
  "Prescription opioid misuse in Canada has become a serious public health concern and has contributed to Canada 's opioid crisis .",
  'The combination of these proinflammatory factors reflects a devastating problem as opioids have high abuse liability and continue to be prescribed for certain patients experiencing HIV-1-related pain .',
  'Prescription opioid and heroin abuse have been increasing steadily year after year , and continue to be a serious national problem .',
  'Abuse of prescription opioid pain relievers continues to be a serious public health concern .',
  'Opioid dependence , a severe addictive disorder and major societal problem , has been demonstrated to be moderately heritable .',
  'Opioid use disorders are considered a serious public health problem among young adults .',
  'Misuse of opioid analgesics and other psychoactive medicines is a serious and increasing problem in Australia .',
  'Increased drug overdose deaths have become a serious public health problem .',
  'Prescription opioid abuse has become a serious national problem .',
  'The opioid epidemic is a severe problem in the world , especially in the United States , where prescription opioid overdose accounts for a quarter of drug overdose deaths .',
  'Opioid-related adverse events are a serious problem in hospitalized patients .',
  'Even originally introduced as efficient anesthetic drugs to relieve moderate-to-severe pain in clinic , the overdose of new synthetic opioids is currently a serious public health problem in numerous countries worldwide .',
  'The opioid epidemic has become a severe public health problem , with approximately 130 opioid-induced deaths occurring each day in the United States .',
  'The opioid epidemic continues to be a serious public health concern .',
  'Nonmedical use may lead to opioid abuse/dependence , a serious public health concern .',
  "Considering fentanyl 's high potency and abuse liability , the recent rise in fentanyl-related deaths is a serious public health concern and signifies the urgent need to establish prevention and treatment efforts .",
  'The high rates of HIV and Hepatitis C ( HCV ) infection among opioid abusers is a serious public health problem , and efforts to enhance knowledge regarding risks for HIV/hepatitis infection in this population are important .',
  'Nonmedical sedative use is emerging as a serious problem in India .',
  'The abuse of opioids is a serious and prevalent problem and research is needed on factors that may place individuals at risk for misusing opioids .',
  'Prescription opioid abuse and addiction , along with consequences such as overdose death and increasing transition to heroin use , constitute a devastating public health problem in the United States .',
  'Opioid use is a severe problem in Iran .',
  'Over the last two decades , opioid-related mortality rates have increased dramatically to become a serious public health concern in the United States .',
  'Opioid abuse is a serious public health concern .',
  'Oxycodone use disorder ( OUD ) is a serious health problem that has prompted a need to develop animal models of OUD that have both face and predictive validity .',
  'Morphine addiction is known as a serious social problem .',
  'Heroin dependence remains a serious and costly public health problem , even in patients receiving methadone maintenance treatment .',
  'Opioid use disorder is a serious public health problem .',
  'Opioid addiction to prescription and illicit drugs is a serious and growing problem .',
  'Prescription opioid misuse is a serious public health concern , yet antecedent factors are poorly described .',
  'Opioid use disorder is a serious international concern with limited treatment success .',
  'Misuse of opioid analgesics , in combination with diversion , dependence , and fatal overdoses , presents a serious problem for public health , which affects many countries worldwide .',
  'Opioid dependence is a serious worldwide health problem .',
  'Severe withdrawal signs which accompany the detoxification of narcotic addicts from opiate drugs are also a serious problem for chronic pain patients taking high levels of analgesic medications .',
  'Nonmedical prescription opioid use ( NMPOU ) is a serious public health problem in North America .',
  'With thousands of people in the United States dying of opioid overdose each month , the opioid epidemic has become a serious public health concern .',
  'However , several recent studies suggested that morphine induces apoptosis in human peripheral blood lymphocytes ( PBLs ) , raising a serious concern about the use of opioid-based analgesic strategies .',
  'Opioid-related respiratory depression ( RD ) is a serious clinical problem as it causes multiple deaths and anoxic brain injuries .',
  'Concomitant opioid abuse is a serious problem among patients receiving methadone maintenance treatment ( MMT ) for opioid use disorder .',
  'Opioid addiction , also referred to as opioid use disorder , continues to be a devastating problem throughout the world .',
  'The high level of prescribed sedative drug use reported by people receiving AOD treatment is a serious public health concern given the increasing incidence of drug overdose deaths in Australia .',
  'The current opioid crisis has created a tragic problem in medicine and society .',
  'Prescription opioid abuse and misuse are a serious problem in the U.S. today .',
  'Opioid addiction and overdose is a serious problem worldwide .',
  'Therefore , given the prevalence of opioid use and abuse , opioid-mediated immune suppression presents a serious concern in our society today .',
  'Opioid abuse is a devastating , costly , and growing problem in the United States , and one for which treatment can be complicated by barriers such as access to care and legal issues .',
  'Overdose is a serious problem as for people addicted to opioid drug injections ( ODI ) as well as for the community in general .',
  'Black participants and those who believed that illegal drug use was a serious problem had greater odds of locking opioids ; participants with higher levels of education or who knew someone who used heroin or misused prescription opioids had lesser odds of locking opioids .',
  'Prescription opioid abuse poses a serious problem in the United States , representing',
  'Continued illicit drug use by opioid-dependent patients maintained on methadone is a serious problem , undermining the goal of methadone maintenance treatment and increasing the risk for HIV .',
  'Opioid overdose was identified as a serious problem in the Richmond area and the United States by 71.9 % and 81.3 % of respondents , respectively .',
  'The comorbidity of chronic pain and opioid addiction is a serious problem that has been growing with the practice of prescribing opioids for chronic pain .',
  'Overdose from opioids is a serious public health and clinical concern . Veterans are at increased risk for opioid overdose compared with the civilian population , suggesting the need for enhanced efforts to address overdose prevention in Department of Veterans Affairs ( VA ) health care settings , such as primary care clinics .',
  'Although tramadol is thought to have low abuse and dependence potentials worldwide , its abuse has become a serious problem in many countries , particularly in the Middle East , Africa , and West Asia .',
  'Among opioid-dependent patients on maintenance therapy , concomitant drug abuse is a serious problem .',
  'Opioid abuse remains a serious public health problem .',
  'Opioid Use disorders are emerging as a serious public health concern in India .',
  'Opiate addiction is a serious problem that has now spread worldwide to all levels of society .'],
 'thalassemia': ['Patients with thalassaemia who received regular transfusions had increased iron accumulation, leading to iron overload, which was associated with oxidative stress.',
  'Thalassemias and hemoglobinopathies are a serious health problem in Turkey .',
  'Iron deposition in the anterior pituitary continues to pose a serious problem in older patients with homozygous beta-thalassemia particularly in terms of gonadal function .',
  'Rasburicase-induced methemoglobinemia is a serious concern , especially in African- American patients .',
  'Since haemoglobin D and S are indistinguishable by most common conventional methods , the geographical coincidence of the two haemoglobin poses a serious screening problem which was investigated in the propositus who is heterozygous for S and D , his wife who is heterozygous for A and S , and their six children .',
  'Hemoglobinopathies are the most common monogenic disorders in humans ; among them , thalassemia constitutes a serious medical and public health problem in high prevalence regions , in a geographical zone ranging from the Mediterranean Basin to China .',
  'Thalassemia was a serious health problem in Cyprus .',
  'Thalassemias represent a serious health problem in areas where their incidence is high .',
  'A serious problem in thalassemia major is growth impairment for which several possible etiologies have been proposed .',
  'Hemolysis due to ineffective erythropoiesis is a serious problem β-thalassemia major ( β-TM ) patients .',
  'The thalassemias and other inherited disorders of hemoglobin are likely to remain a serious global health problem for the foreseeable future .',
  'Thalassemias are the most frequent monogenic disorders around the world and are a serious health problem in areas with a high incidence .',
  'Despite recent progress in iron chelation therapy , sudden cardiac death due to malignant ventricular arrhythmias remains a vexing , clinical problem in patients with beta-thalassemia major ( TM ) .',
  'Hemoglobinopathies are common inherited monogenic diseases that are likely to remain a serious regional health problem where thalassemias and sickle cell disease are prevalent .',
  'beta-Thalassemia is a serious health problem in the United States , especially in California , due to increased Asian immigration .',
  'Our study suggests that genetic discrimination is already a serious problem and that any proposed screening program for hemochromatosis or other genetic condition must consider and attempt to mitigate its effects .',
  'Homozygosity for the alpha(0)-thalassemia deletion ( --/-- ) is a serious health problem in Southeast Asia and the Philippines and is responsible for the majority of hydrops fetalis in this region .'],
 'thalassemias': ['Patients with thalassaemia who received regular transfusions had increased iron accumulation, leading to iron overload, which was associated with oxidative stress.',
  'Thalassemias and hemoglobinopathies are a serious health problem in Turkey .',
  'Iron deposition in the anterior pituitary continues to pose a serious problem in older patients with homozygous beta-thalassemia particularly in terms of gonadal function .',
  'Rasburicase-induced methemoglobinemia is a serious concern , especially in African- American patients .',
  'Since haemoglobin D and S are indistinguishable by most common conventional methods , the geographical coincidence of the two haemoglobin poses a serious screening problem which was investigated in the propositus who is heterozygous for S and D , his wife who is heterozygous for A and S , and their six children .',
  'Hemoglobinopathies are the most common monogenic disorders in humans ; among them , thalassemia constitutes a serious medical and public health problem in high prevalence regions , in a geographical zone ranging from the Mediterranean Basin to China .',
  'Thalassemia was a serious health problem in Cyprus .',
  'Thalassemias represent a serious health problem in areas where their incidence is high .',
  'A serious problem in thalassemia major is growth impairment for which several possible etiologies have been proposed .',
  'Hemolysis due to ineffective erythropoiesis is a serious problem β-thalassemia major ( β-TM ) patients .',
  'The thalassemias and other inherited disorders of hemoglobin are likely to remain a serious global health problem for the foreseeable future .',
  'Thalassemias are the most frequent monogenic disorders around the world and are a serious health problem in areas with a high incidence .',
  'Despite recent progress in iron chelation therapy , sudden cardiac death due to malignant ventricular arrhythmias remains a vexing , clinical problem in patients with beta-thalassemia major ( TM ) .',
  'Hemoglobinopathies are common inherited monogenic diseases that are likely to remain a serious regional health problem where thalassemias and sickle cell disease are prevalent .',
  'beta-Thalassemia is a serious health problem in the United States , especially in California , due to increased Asian immigration .',
  'Our study suggests that genetic discrimination is already a serious problem and that any proposed screening program for hemochromatosis or other genetic condition must consider and attempt to mitigate its effects .',
  'Homozygosity for the alpha(0)-thalassemia deletion ( --/-- ) is a serious health problem in Southeast Asia and the Philippines and is responsible for the majority of hydrops fetalis in this region .'],
 'hemoglobinopathies': ['Patients with thalassaemia who received regular transfusions had increased iron accumulation, leading to iron overload, which was associated with oxidative stress.',
  'Thalassemias and hemoglobinopathies are a serious health problem in Turkey .',
  'Iron deposition in the anterior pituitary continues to pose a serious problem in older patients with homozygous beta-thalassemia particularly in terms of gonadal function .',
  'Rasburicase-induced methemoglobinemia is a serious concern , especially in African- American patients .',
  'Since haemoglobin D and S are indistinguishable by most common conventional methods , the geographical coincidence of the two haemoglobin poses a serious screening problem which was investigated in the propositus who is heterozygous for S and D , his wife who is heterozygous for A and S , and their six children .',
  'Hemoglobinopathies are the most common monogenic disorders in humans ; among them , thalassemia constitutes a serious medical and public health problem in high prevalence regions , in a geographical zone ranging from the Mediterranean Basin to China .',
  'Thalassemia was a serious health problem in Cyprus .',
  'Thalassemias represent a serious health problem in areas where their incidence is high .',
  'A serious problem in thalassemia major is growth impairment for which several possible etiologies have been proposed .',
  'Hemolysis due to ineffective erythropoiesis is a serious problem β-thalassemia major ( β-TM ) patients .',
  'The thalassemias and other inherited disorders of hemoglobin are likely to remain a serious global health problem for the foreseeable future .',
  'Thalassemias are the most frequent monogenic disorders around the world and are a serious health problem in areas with a high incidence .',
  'Despite recent progress in iron chelation therapy , sudden cardiac death due to malignant ventricular arrhythmias remains a vexing , clinical problem in patients with beta-thalassemia major ( TM ) .',
  'Hemoglobinopathies are common inherited monogenic diseases that are likely to remain a serious regional health problem where thalassemias and sickle cell disease are prevalent .',
  'beta-Thalassemia is a serious health problem in the United States , especially in California , due to increased Asian immigration .',
  'Our study suggests that genetic discrimination is already a serious problem and that any proposed screening program for hemochromatosis or other genetic condition must consider and attempt to mitigate its effects .',
  'Homozygosity for the alpha(0)-thalassemia deletion ( --/-- ) is a serious health problem in Southeast Asia and the Philippines and is responsible for the majority of hydrops fetalis in this region .'],
 'appendicitis': ['Appendicitis is the most common gastrointestinal pediatric surgical emergency.',
  'Peristomal pyoderma gangrenosum (PPG) is a rare complication mainly associated with inflammatory bowel disease',
  "Postoperative intra-abdominal septic complications are a serious concern with regard to postoperative morbidity and mortality in Crohn 's disease .",
  'Abdominal infection complicating abdominal operation is a serious clinical problem that is subject to diagnostic delay , which is a risk factor for adverse outcomes .',
  'Intra-abdominal infections are a serious problem for surgeons .',
  'Major disruption of abdominal wounds continues to be a serious problem , despite the infrequency of its occurrence .',
  "Fournier 's syndrome or necrotizing fasceitis of the abdominal-perineal region is a severe acute problem which may lead to a systemic impairment and eventually to death .",
  'Intra-abdominal actinomycosis may present a serious diagnostic problem both pre- and peroperatively and can lead to extensive surgical intervention due to the anticipation of malignancy .',
  'Intra-abdominal abscess , resulting either from primary intraperitoneal disease or as a complication of surgery , remains a serious problem with high patient mortality if not treated early and adequately .',
  'Following continent ileostomy or restorative proctocolectomy ileitis can become a serious clinical problem and is then known as pouchitis although this condition is yet to be clearly defined .',
  'Intra-abdominal infections ( IAI ) continue to be a serious clinical problem .',
  'Free air of unknown origin within the abdominal cavity is a serious problem , which in the majority of cases indicates the perforation of a hollow organ .',
  'Small bowel perforations with peritonitis pose a serious problem to an emergency surgeon because of the lack of any uniformity of opinion regarding the optimum surgical treatment to be performed .',
  'A surgical compress retained in the abdominal cavity following surgery is a serious problem .',
  'Acute appendicitis due to a foreign body , without an anamnestic of either surgery or injury may cause a severe diagnostic dilemma .',
  'A serious conundrum for surgeons : Stump appendicitis .',
  'Deaths and complications related to proctocolectomy in inflammatory bowel disease remain a serious problem for the general surgeon .',
  'In contrast , pneumoperitoneum due to visceral perforation represents a serious clinical problem and usually needs an urgent surgical intervention .',
  'The spontaneous cystoplasty perforation is a serious and potentially fatal problem if a delay in diagnosis and treatment occurs .',
  "Retroperitoneal perforation of the duodenum , caused by abdominal trauma , endoscopic examination or diverticulitis , is a serious clinical problem , because of it 's lack of specific symptoms .",
  'The management of a septic peritonitis open abdomen is a serious problem for clinicians .',
  'Abdominal abscesses arising postoperatively constitute a serious problem , particularly in the field of oncological surgery .'],
 'perforation': ['Appendicitis is the most common gastrointestinal pediatric surgical emergency.',
  'Peristomal pyoderma gangrenosum (PPG) is a rare complication mainly associated with inflammatory bowel disease',
  "Postoperative intra-abdominal septic complications are a serious concern with regard to postoperative morbidity and mortality in Crohn 's disease .",
  'Abdominal infection complicating abdominal operation is a serious clinical problem that is subject to diagnostic delay , which is a risk factor for adverse outcomes .',
  'Intra-abdominal infections are a serious problem for surgeons .',
  'Major disruption of abdominal wounds continues to be a serious problem , despite the infrequency of its occurrence .',
  "Fournier 's syndrome or necrotizing fasceitis of the abdominal-perineal region is a severe acute problem which may lead to a systemic impairment and eventually to death .",
  'Intra-abdominal actinomycosis may present a serious diagnostic problem both pre- and peroperatively and can lead to extensive surgical intervention due to the anticipation of malignancy .',
  'Intra-abdominal abscess , resulting either from primary intraperitoneal disease or as a complication of surgery , remains a serious problem with high patient mortality if not treated early and adequately .',
  'Following continent ileostomy or restorative proctocolectomy ileitis can become a serious clinical problem and is then known as pouchitis although this condition is yet to be clearly defined .',
  'Intra-abdominal infections ( IAI ) continue to be a serious clinical problem .',
  'Free air of unknown origin within the abdominal cavity is a serious problem , which in the majority of cases indicates the perforation of a hollow organ .',
  'Small bowel perforations with peritonitis pose a serious problem to an emergency surgeon because of the lack of any uniformity of opinion regarding the optimum surgical treatment to be performed .',
  'A surgical compress retained in the abdominal cavity following surgery is a serious problem .',
  'Acute appendicitis due to a foreign body , without an anamnestic of either surgery or injury may cause a severe diagnostic dilemma .',
  'A serious conundrum for surgeons : Stump appendicitis .',
  'Deaths and complications related to proctocolectomy in inflammatory bowel disease remain a serious problem for the general surgeon .',
  'In contrast , pneumoperitoneum due to visceral perforation represents a serious clinical problem and usually needs an urgent surgical intervention .',
  'The spontaneous cystoplasty perforation is a serious and potentially fatal problem if a delay in diagnosis and treatment occurs .',
  "Retroperitoneal perforation of the duodenum , caused by abdominal trauma , endoscopic examination or diverticulitis , is a serious clinical problem , because of it 's lack of specific symptoms .",
  'The management of a septic peritonitis open abdomen is a serious problem for clinicians .',
  'Abdominal abscesses arising postoperatively constitute a serious problem , particularly in the field of oncological surgery .'],
 'hpv': ['Uptake of human papillomavirus (HPV) vaccination is suboptimal among some groups.',
  'Vulvar cancer and vaginal cancer are relatively rare tumors, and there had been no established treatment principles or guidelines to treat these rare tumors in Japan',
  'Cervical cancer continues to be a serious public health problem in the developing world , including China .',
  'Cervical cancer ( CC ) is a malignant tumor which for many years has been a serious epidemiological problem in Poland .',
  'Cervical cancer represents a severe public health problem and has been associated to the presence of human papillomavirus .',
  'Cervical cancer is a serious public health problem in Thailand .',
  'This is a first study showing significantly a very high prevalence of HPV infection in adolescent and young adult tribal girls possibly due to different socio-sexual behavior , indicating a serious health concern for Indian tribal women .',
  'Cervical HPV infection is a serious and gradually growing problem for Turkish women according to hospital-based data .',
  'Cervical cancer is a serious public health problem in women in developing countries because of absence or ineffectiveness of screening programs .',
  'Cervical cancer is a serious health problem , with nearly 500000 women developing the disease each year worldwide .',
  'For patients with cervical cancer , despite the incidence and mortality rates have been declining in recent years , due to its huge population base , cervical cancer has always been a serious public health problem .',
  'Cervical cancer remains a serious public health problem in the world ; that is why the Mexican Federation of Schools of Obstetrics and Gynecology convened the elaboration of a consensus that is devoted this number of Ginecologia y Obstetricia de Mexico .',
  'of participants considered cervical cancer as a severe health problem , the only statistically significant relationships',
  'Cervical cancer is a serious public health problem in South Africa .',
  'Human papillomaviruses ( HPVs ) remain a serious world health problem due to their association with anogenital/oral cancers and warts .',
  'Cervical cancer is one of the most common gynecological malignant tumors and is the cause of a serious health problem worldwide .',
  'Human papillomaviruses ( HPVs ) remain a serious world health problem due to their association with cervical and head and neck cancers .',
  'Cervical cancer is a serious global health problem .',
  'The Pap smear has an important value in the early diagnosis of cervical cancer , a serious problem in womens health .',
  'Cervical cancer is a serious worldwide health problem .',
  'Human papillomavirus is one of the most frequent sexually transmitted infections among women and constitutes a serious health problem among youth .',
  'Human papillomavirus ( HPV ) associated head and neck squamous cell carcinomas ( HNSCCs ) , have become a serious global health problem .',
  'HPV infections did not affect the discrepancy between smear-biopsy ( p = 0.533 ) , smear-LEEP ( p = 1.000 ) and biopsy-LEEP ( p = 0.529 ) CONCLUSIONS : Smear technique has a serious discrepancy and under-diagnosis problem when its results are compared with biopsy and LEEP .',
  'Cervical cancer : a preventable problem .',
  'In conclusion , anal cancer remains a serious problem in predominantly HIV+ MSM .',
  'Cervical cancer is a serious public health problem with high geographical variations in incidence , mainly due to historical patterns of risk factors and the influence of screening activities .',
  'Cervical cancer ( CC ) is a serious public health concern in Serbia , due to opportunistic screening still being in force , which led to twice higher than the average incidence rate of cervical cancer in Europe .',
  'Gynecologic malignant neoplasms are a severe health problem among female patients , of which cervical cancer ( CC ) , in particular , is a common disease leading to high mortality rates .',
  'Though cervical cancer is a preventable and treatable cancer , the challenges to cervical control in SSA are great and will require a broadly integrated and sustained effort by multiple stakeholders before meaningful progress can be achieved .',
  'Anal melanoma remains a deadly problem .',
  'Early detection of CIN is of utmost importance for preventing cervical cancer , a serious and frequent health problem in Romania .',
  'The infection with human papillomavirus ( HPV ) represents a serious health problem in the world .',
  'Cervical cancer is a serious public health problem and is associated with high cancer-related mortality in females worldwide .',
  'Cervical cancer ( CC ) is classified as the fourth most common type of cancer in women worldwide and remains a serious public health problem in many underdeveloped countries .',
  'Cervical cancer in women during pregnancy and puerperium is a serious diagnostic and therapeutic problem .',
  'Despite screening , cervical cancer ( CC ) remains a serious health care problem .',
  'Infection with HPV , particularly HPV16 , remains a serious health problem due to its major risk factor contributing to cervical cancer .',
  'Cervical carcinoma represents a serious medical and social problem .',
  'Anal cancer is a serious health problem in HIV-positive men who have sex with men , and precursor lesions , anal intraepithelial neoplasia , are well defined .',
  'Cervical cancer is a serious problem in developing countries because early detection is difficult , and thus proper early treatment is many times missing .',
  'Cervical cancer is a preventable public health problem .',
  'Uterine cervical cancer in Latin American women is a serious health problem .',
  'Cervical cancer constitutes a serious public health problem in Poland as well as worldwide .',
  'Cervical cancer remains a serious health problem till now , with nearly 500,000 women cases diagnosed each year around the world .',
  'Cervical cancer is a serious public-health problem in Asian countries .',
  "These very high figures show that on the one hand precancerous cervical lesions represent a serious public health concern in Senegal , on the other hand regular detection has become an urgent need in Dakar and in the other regions of Senegal where it 's not carried out at all at the present time .",
  'Cervical cancer is a preventable health problem , yet is the second most common cancer of women worldwide .',
  'The results of this study indicate that genital tract and breast cancers constitute a serious public health problem pointing out the importance of screening activities in the Somme area .',
  'Although effective strategies for preventing cancer of the uterine cervix exist , this disease continues to be a serious health problem worldwide , especially in developing countries .',
  'Cervical cancer is one of the most common gynecologic malignancies and poses a serious health problem worldwide .',
  'Vulvar malignancies represent a serious gynecologic health concern , especially given the increasing incidence over the past several decades .',
  'Cervical cancer is a serious public health problem in developing countries .',
  'Cervical cancer is a serious problem in developing countries because it is usually not detected at an early stage .',
  'Most recently published guidelines do not recommend routine anal cytology , but anal cancer is undoubtedly a serious and growing problem for HIV-positive patients .',
  'The respondents in this study showed good knowledge of cervical cancer as all ( 388 ) were aware that cervical cancer is a preventable disease of public health concern .',
  'Human Papillomavirus ( HPV ) infection is a serious problem for human immunodeficiency virus (HIV)-infected women , increases their risk of cervical lesions and cancer .',
  'Cervical cancer is a serious health problem in Taiwan , with nearly 2700 women developing the disease each year .',
  'Cervical cancer is one of the most common gynecological malignancies that causes a serious health problem worldwide .',
  'Cervical cancer has posed a serious problem in Thailand for decades .',
  'Although in developed countries the incidence of cervical cancer seems to be declining , it remains a serious health problem .',
  'Cervical is a troublesome clinical problem .',
  'Cervical cancer is a serious public health problem in Brazil .',
  'HPV-related pathologies in HIV-infected men are a serious concern .',
  'Carcinoma of the cervix remains a serious problem worldwide .',
  'Although oral HPV infection is a serious concern , the authors found that periodontitis was not shown to be related to the presence of HPV in oral rinse specimens in adjusted analyses in this study .'],
 'alzheimer': ["Alzheimer's disease (AD) is a neurodegenerative disease, which is associated with malnutrition and hyperhomocysteine.",
  'Amyloidosis is particularly difficult to diagnose because the signs and symptoms are subtle',
  'A problem with equating studies from different groups is that different criteria have been used to define AD , so that establishing the relevance of cortical Lewy bodies themselves to cognitive decline and separating this from the contribution which may be related to the AD pathology is problematic .',
  'A major problem with most active and passive immunization approaches for AD is that both the normal sAβ and pathogenic forms are equally targeted with the potential of autoimmune inflammation .',
  "Alzheimer 's disease ( AD ) is a severe neurodegenerative disorder and has become a global public health problem .",
  "Alzheimer 's disease ( AD ) is a devastating public health problem that affects over 5.4 million Americans .",
  'AD presents a serious global health concern with no cure to date , reflecting the complexity of its pathogenesis .',
  "Alzheimer 's disease ( AD ) is widely recognized as a serious public health problem and heavy financial burden .",
  "Associated with the aging of our world population is a sharp increase in the incidence of Alzheimer 's disease , which not only poses a significant health issue but also presents a serious social problem .",
  "Alzheimer 's disease ( AD ) is a serious health concern , affecting millions of people globally , which leads to cognitive impairment , dementia , and inevitable death .",
  "Alzheimer 's disease ( AD ) is a devastating neurodegenerative disorder and a major medical problem .",
  'Brain diseases affect millions of people worldwide , and this number will grow as the size of elderly population increases , thus making brain disease a serious public health problem .',
  'Alzheimer disease ( AD ) is a devastating disease and a global health problem , and current treatments are only symptomatic .',
  "But the very success of this widespread acceptance and popularization has produced a troubling dilemma regarding the subjectivity of the person diagnosed with Alzheimer 's disease .",
  'Tangles , Toxicity , and Tau Secretion in AD - New Approaches to a Vexing Problem .',
  "Alzheimer 's disease ( AD ) is a severe age dependent and chronic problem with no cure so far .",
  "Nowadays , neurodegenerative disorders such as Alzheimer 's disease have become a serious public health problem .",
  'In addition , the advanced age and frail nature of patients with AD mean that poor tolerability is a serious concern .',
  "Elucidating the molecular mechanisms in the development of such a devastating neurodegenerative disorder as Alzheimer 's disease ( AD ) is currently one of the major challenges of molecular medicine .",
  "Alzheimer 's disease ( AD ) , an age-related neurodegenerative disorder and a serious public health concern , is mainly caused by β-amyloid (Aβ)-induced toxicity .",
  "Alzheimer 's disease ( AD ) has high a prevalence rate , high medical costs , and care difficulties , and has become a serious social and economic problem in our aging society .",
  "Alzheimer 's disease is the most common form of dementia and is a serious health problem .",
  "Alzheimer 's disease ( AD ) is a debilitating neurodegenerative disease that causes a progressive decline in memory , language and problem solving ."],
 'neurodegenerative': ["Alzheimer's disease (AD) is a neurodegenerative disease, which is associated with malnutrition and hyperhomocysteine.",
  'Amyloidosis is particularly difficult to diagnose because the signs and symptoms are subtle',
  'A problem with equating studies from different groups is that different criteria have been used to define AD , so that establishing the relevance of cortical Lewy bodies themselves to cognitive decline and separating this from the contribution which may be related to the AD pathology is problematic .',
  'A major problem with most active and passive immunization approaches for AD is that both the normal sAβ and pathogenic forms are equally targeted with the potential of autoimmune inflammation .',
  "Alzheimer 's disease ( AD ) is a severe neurodegenerative disorder and has become a global public health problem .",
  "Alzheimer 's disease ( AD ) is a devastating public health problem that affects over 5.4 million Americans .",
  'AD presents a serious global health concern with no cure to date , reflecting the complexity of its pathogenesis .',
  "Alzheimer 's disease ( AD ) is widely recognized as a serious public health problem and heavy financial burden .",
  "Associated with the aging of our world population is a sharp increase in the incidence of Alzheimer 's disease , which not only poses a significant health issue but also presents a serious social problem .",
  "Alzheimer 's disease ( AD ) is a serious health concern , affecting millions of people globally , which leads to cognitive impairment , dementia , and inevitable death .",
  "Alzheimer 's disease ( AD ) is a devastating neurodegenerative disorder and a major medical problem .",
  'Brain diseases affect millions of people worldwide , and this number will grow as the size of elderly population increases , thus making brain disease a serious public health problem .',
  'Alzheimer disease ( AD ) is a devastating disease and a global health problem , and current treatments are only symptomatic .',
  "But the very success of this widespread acceptance and popularization has produced a troubling dilemma regarding the subjectivity of the person diagnosed with Alzheimer 's disease .",
  'Tangles , Toxicity , and Tau Secretion in AD - New Approaches to a Vexing Problem .',
  "Alzheimer 's disease ( AD ) is a severe age dependent and chronic problem with no cure so far .",
  "Nowadays , neurodegenerative disorders such as Alzheimer 's disease have become a serious public health problem .",
  'In addition , the advanced age and frail nature of patients with AD mean that poor tolerability is a serious concern .',
  "Elucidating the molecular mechanisms in the development of such a devastating neurodegenerative disorder as Alzheimer 's disease ( AD ) is currently one of the major challenges of molecular medicine .",
  "Alzheimer 's disease ( AD ) , an age-related neurodegenerative disorder and a serious public health concern , is mainly caused by β-amyloid (Aβ)-induced toxicity .",
  "Alzheimer 's disease ( AD ) has high a prevalence rate , high medical costs , and care difficulties , and has become a serious social and economic problem in our aging society .",
  "Alzheimer 's disease is the most common form of dementia and is a serious health problem .",
  "Alzheimer 's disease ( AD ) is a debilitating neurodegenerative disease that causes a progressive decline in memory , language and problem solving ."],
 'epilepsy': ['Epilepsy in the cat is a serious medical condition.',
  'Epilepsy is a serious neurological disorder associated with a high level of psychiatric comorbidity',
  'The selection of optimal target areas in the surgical treatment of epilepsy is always a difficult problem in medicine',
  'The problem with this approach is that some antiepileptic drugs ( AEDs ) are mitochondrial toxic and care is , therefore , needed when administering these AEDs to patients with MIDs .',
  'A problem with the inspection of IEDs from the scalp electroencephalogram ( sEEG ) is that for a subset of epileptic patients , there are no visually discernible IEDs on the scalp , rendering the above procedures ineffective , both for detection purposes and algorithm evaluation .',
  'A drawback of carbamazepine ( CBZ ) , a major antiepileptic drug ( AED ) with clinical efficacy against partial and generalized convulsive seizures , is its isolubility in aqueous vehicles , which is generally considered a contraindication to parenteral administration in epileptic patients .',
  'Interactions between analgesics and anti-epileptic drugs may sometimes present a serious clinical problem .',
  'Our data indicate that hyperhomocysteinemia may not be a serious clinical problem among patients with epilepsy , who receive either LTG or VPA .',
  'Dissociative seizures ( DSs ) , also called psychogenic non-epileptic seizures , are a distressing and disabling problem for many patients in neurological settings with high and often unnecessary economic costs .',
  'Epilepsy is a serious health problem associated with an increased risk of premature mortality .',
  'Tolerance to drug treatment is a serious problem in the treatment of epilepsy .',
  'Epilepsy is a serious health concern which often associates with other neurobehavioral comorbidities that further worsen disease conditions .',
  'Medically intractable temporal lobe epilepsy ( TLE ) remains a serious health problem .',
  'Dropout from epilepsy programmes is a serious problem in developing countries and has not been systematically studied before .',
  'Epileptic seizure is a serious health problem in the world and there is a huge population suffering from it every year .',
  'Although study findings can not be generalized , we conclude that lack of attention to factors impacting on management of epilepsy is a serious concern and may lead to violations of health rights .',
  'Drug-induced exacerbation of seizures is a serious and common clinical problem that is often unrecognized or overlooked by the treating physician .',
  'Adverse cutaneous drug reactions associated with antiepileptic drugs ( AEDs ) are a serious problem in the clinical setting .',
  'With the ever-increasing popularity of computers , electronic screen game-induced seizure ( ESGS ) is beginning to pose a serious social problem .',
  'Moreover , multidrug resistance is a serious problem in epilepsy treatment .',
  'While convulsions associated with fever represent a serious problem in pediatric medicine , conventional animal models of febrile convulsions suffer numerous technical limitations .',
  'Injuries from seizures are a serious , persistent problem in childhood onset epilepsy : a population-based study .',
  'Uncontrolled seizures are a serious problem and a source of much anxiety to physicians , parents and others concerned with the care of children with epilepsy .',
  'Intractable epilepsy is a serious neurologic problem with different etiologies .',
  'The Byzantine physicians considered epilepsy to be a serious medical problem and followed the Hippocratic tradition as far as the etiology of this disease is concerned .',
  'Epilepsy , one of the most common neurological diseases with spontaneous recurrent seizures , is a severe health problem globally .',
  'The syndrome of malignant migrating partial seizures in infancy is a devastating , age-specific , epileptic encephalopathy , which still presents an aetiological , pathophysiological and therapeutic problem .',
  'Sudden unexpected death in epilepsy ( SUDEP ) is a serious concern for epilepsy patients .',
  'Photosensitivity can represent a serious problem in epilepsy patients , also because pharmacologic treatment is often ineffective .',
  'Our data suggest that hyperhomocysteinemia is not a serious clinical concern in epileptic patients when folate nutriture is adequate .',
  'The estimation of Michaelis-Menten pharmacokinetic parameters in patients with epilepsy receiving phenytoin continues to be a vexing problem .',
  'Epilepsy is a neurological disorder characterized by an enduring predisposition to generate and aggravate epileptic seizures affecting around 1 % of global population making it a serious health concern .',
  'Epileptic spasms during infancy ( infantile spasms ) represent a serious treatment and social problem despite their rare occurrence .',
  'Due to their widely differentiated etiology , seizures and related conditions pose a serious diagnostic and certification problem .',
  'Aggravation of idiopathic generalized epilepsy ( IGE ) syndromes by inappropriate antiepileptic drugs ( AEDs ) is increasingly recognized as a serious and common problem .',
  'Sudden Unexpected Death in Epilepsy ( SUDEP ) has increased in awareness considerably over the last two decades and is acknowledged as a serious problem in epilepsy .',
  'Managing anti-epileptic drug treatment in adult patients with intellectual disability : a serious conundrum .',
  'Purpose . Psychiatric disorders emerging after temporal lobe resections are a serious problem threatening the surgical success of patients with epilepsy .',
  'Epilepsy was referred to as a serious medical problem with poor outcome by the Byzantine physicians .',
  'Once the diagnosis has been established , severe convulsions , often unpredictable and long-lasting , are still a major worry , but developmental and behavioural problems also rapidly become a serious concern .',
  'Generalized convulsions in the afebrile infant represent a serious and etiopathogenically very heterogeneous problem .',
  'Pharmacoresistance of AEDs in the treatment of epilepsy and psychiatric disorders is a serious problem .',
  'Childhood epilepsies are a serious and sizeable problem , and children with epilepsy have many needs .',
  'Depression in patients with epilepsy is a serious medical and social problem since it afflicts almost one half of all patients treated in epilepsy referral centers .',
  'Conditions , in which neurodevelopmental disorders are associated with the marked epileptiform EEG activity , while clinical epileptic seizures are absent , represent a serious problem .',
  'Accurate and consistent classification of cause of death among individuals with epilepsy remains a dire public health concern .',
  'Although most FS may not represent a serious health problem , those that are more prolonged and recurrent may cause hippocampal damage which is the most important pathological basis of temporal lobe epilepsy .',
  'Epilepsy represents a serious medical and social problem .'],
 'seizures': ['Epilepsy in the cat is a serious medical condition.',
  'Epilepsy is a serious neurological disorder associated with a high level of psychiatric comorbidity',
  'The selection of optimal target areas in the surgical treatment of epilepsy is always a difficult problem in medicine',
  'The problem with this approach is that some antiepileptic drugs ( AEDs ) are mitochondrial toxic and care is , therefore , needed when administering these AEDs to patients with MIDs .',
  'A problem with the inspection of IEDs from the scalp electroencephalogram ( sEEG ) is that for a subset of epileptic patients , there are no visually discernible IEDs on the scalp , rendering the above procedures ineffective , both for detection purposes and algorithm evaluation .',
  'A drawback of carbamazepine ( CBZ ) , a major antiepileptic drug ( AED ) with clinical efficacy against partial and generalized convulsive seizures , is its isolubility in aqueous vehicles , which is generally considered a contraindication to parenteral administration in epileptic patients .',
  'Interactions between analgesics and anti-epileptic drugs may sometimes present a serious clinical problem .',
  'Our data indicate that hyperhomocysteinemia may not be a serious clinical problem among patients with epilepsy , who receive either LTG or VPA .',
  'Dissociative seizures ( DSs ) , also called psychogenic non-epileptic seizures , are a distressing and disabling problem for many patients in neurological settings with high and often unnecessary economic costs .',
  'Epilepsy is a serious health problem associated with an increased risk of premature mortality .',
  'Tolerance to drug treatment is a serious problem in the treatment of epilepsy .',
  'Epilepsy is a serious health concern which often associates with other neurobehavioral comorbidities that further worsen disease conditions .',
  'Medically intractable temporal lobe epilepsy ( TLE ) remains a serious health problem .',
  'Dropout from epilepsy programmes is a serious problem in developing countries and has not been systematically studied before .',
  'Epileptic seizure is a serious health problem in the world and there is a huge population suffering from it every year .',
  'Although study findings can not be generalized , we conclude that lack of attention to factors impacting on management of epilepsy is a serious concern and may lead to violations of health rights .',
  'Drug-induced exacerbation of seizures is a serious and common clinical problem that is often unrecognized or overlooked by the treating physician .',
  'Adverse cutaneous drug reactions associated with antiepileptic drugs ( AEDs ) are a serious problem in the clinical setting .',
  'With the ever-increasing popularity of computers , electronic screen game-induced seizure ( ESGS ) is beginning to pose a serious social problem .',
  'Moreover , multidrug resistance is a serious problem in epilepsy treatment .',
  'While convulsions associated with fever represent a serious problem in pediatric medicine , conventional animal models of febrile convulsions suffer numerous technical limitations .',
  'Injuries from seizures are a serious , persistent problem in childhood onset epilepsy : a population-based study .',
  'Uncontrolled seizures are a serious problem and a source of much anxiety to physicians , parents and others concerned with the care of children with epilepsy .',
  'Intractable epilepsy is a serious neurologic problem with different etiologies .',
  'The Byzantine physicians considered epilepsy to be a serious medical problem and followed the Hippocratic tradition as far as the etiology of this disease is concerned .',
  'Epilepsy , one of the most common neurological diseases with spontaneous recurrent seizures , is a severe health problem globally .',
  'The syndrome of malignant migrating partial seizures in infancy is a devastating , age-specific , epileptic encephalopathy , which still presents an aetiological , pathophysiological and therapeutic problem .',
  'Sudden unexpected death in epilepsy ( SUDEP ) is a serious concern for epilepsy patients .',
  'Photosensitivity can represent a serious problem in epilepsy patients , also because pharmacologic treatment is often ineffective .',
  'Our data suggest that hyperhomocysteinemia is not a serious clinical concern in epileptic patients when folate nutriture is adequate .',
  'The estimation of Michaelis-Menten pharmacokinetic parameters in patients with epilepsy receiving phenytoin continues to be a vexing problem .',
  'Epilepsy is a neurological disorder characterized by an enduring predisposition to generate and aggravate epileptic seizures affecting around 1 % of global population making it a serious health concern .',
  'Epileptic spasms during infancy ( infantile spasms ) represent a serious treatment and social problem despite their rare occurrence .',
  'Due to their widely differentiated etiology , seizures and related conditions pose a serious diagnostic and certification problem .',
  'Aggravation of idiopathic generalized epilepsy ( IGE ) syndromes by inappropriate antiepileptic drugs ( AEDs ) is increasingly recognized as a serious and common problem .',
  'Sudden Unexpected Death in Epilepsy ( SUDEP ) has increased in awareness considerably over the last two decades and is acknowledged as a serious problem in epilepsy .',
  'Managing anti-epileptic drug treatment in adult patients with intellectual disability : a serious conundrum .',
  'Purpose . Psychiatric disorders emerging after temporal lobe resections are a serious problem threatening the surgical success of patients with epilepsy .',
  'Epilepsy was referred to as a serious medical problem with poor outcome by the Byzantine physicians .',
  'Once the diagnosis has been established , severe convulsions , often unpredictable and long-lasting , are still a major worry , but developmental and behavioural problems also rapidly become a serious concern .',
  'Generalized convulsions in the afebrile infant represent a serious and etiopathogenically very heterogeneous problem .',
  'Pharmacoresistance of AEDs in the treatment of epilepsy and psychiatric disorders is a serious problem .',
  'Childhood epilepsies are a serious and sizeable problem , and children with epilepsy have many needs .',
  'Depression in patients with epilepsy is a serious medical and social problem since it afflicts almost one half of all patients treated in epilepsy referral centers .',
  'Conditions , in which neurodevelopmental disorders are associated with the marked epileptiform EEG activity , while clinical epileptic seizures are absent , represent a serious problem .',
  'Accurate and consistent classification of cause of death among individuals with epilepsy remains a dire public health concern .',
  'Although most FS may not represent a serious health problem , those that are more prolonged and recurrent may cause hippocampal damage which is the most important pathological basis of temporal lobe epilepsy .',
  'Epilepsy represents a serious medical and social problem .'],
 'epileptic': ['Epilepsy in the cat is a serious medical condition.',
  'Epilepsy is a serious neurological disorder associated with a high level of psychiatric comorbidity',
  'The selection of optimal target areas in the surgical treatment of epilepsy is always a difficult problem in medicine',
  'The problem with this approach is that some antiepileptic drugs ( AEDs ) are mitochondrial toxic and care is , therefore , needed when administering these AEDs to patients with MIDs .',
  'A problem with the inspection of IEDs from the scalp electroencephalogram ( sEEG ) is that for a subset of epileptic patients , there are no visually discernible IEDs on the scalp , rendering the above procedures ineffective , both for detection purposes and algorithm evaluation .',
  'A drawback of carbamazepine ( CBZ ) , a major antiepileptic drug ( AED ) with clinical efficacy against partial and generalized convulsive seizures , is its isolubility in aqueous vehicles , which is generally considered a contraindication to parenteral administration in epileptic patients .',
  'Interactions between analgesics and anti-epileptic drugs may sometimes present a serious clinical problem .',
  'Our data indicate that hyperhomocysteinemia may not be a serious clinical problem among patients with epilepsy , who receive either LTG or VPA .',
  'Dissociative seizures ( DSs ) , also called psychogenic non-epileptic seizures , are a distressing and disabling problem for many patients in neurological settings with high and often unnecessary economic costs .',
  'Epilepsy is a serious health problem associated with an increased risk of premature mortality .',
  'Tolerance to drug treatment is a serious problem in the treatment of epilepsy .',
  'Epilepsy is a serious health concern which often associates with other neurobehavioral comorbidities that further worsen disease conditions .',
  'Medically intractable temporal lobe epilepsy ( TLE ) remains a serious health problem .',
  'Dropout from epilepsy programmes is a serious problem in developing countries and has not been systematically studied before .',
  'Epileptic seizure is a serious health problem in the world and there is a huge population suffering from it every year .',
  'Although study findings can not be generalized , we conclude that lack of attention to factors impacting on management of epilepsy is a serious concern and may lead to violations of health rights .',
  'Drug-induced exacerbation of seizures is a serious and common clinical problem that is often unrecognized or overlooked by the treating physician .',
  'Adverse cutaneous drug reactions associated with antiepileptic drugs ( AEDs ) are a serious problem in the clinical setting .',
  'With the ever-increasing popularity of computers , electronic screen game-induced seizure ( ESGS ) is beginning to pose a serious social problem .',
  'Moreover , multidrug resistance is a serious problem in epilepsy treatment .',
  'While convulsions associated with fever represent a serious problem in pediatric medicine , conventional animal models of febrile convulsions suffer numerous technical limitations .',
  'Injuries from seizures are a serious , persistent problem in childhood onset epilepsy : a population-based study .',
  'Uncontrolled seizures are a serious problem and a source of much anxiety to physicians , parents and others concerned with the care of children with epilepsy .',
  'Intractable epilepsy is a serious neurologic problem with different etiologies .',
  'The Byzantine physicians considered epilepsy to be a serious medical problem and followed the Hippocratic tradition as far as the etiology of this disease is concerned .',
  'Epilepsy , one of the most common neurological diseases with spontaneous recurrent seizures , is a severe health problem globally .',
  'The syndrome of malignant migrating partial seizures in infancy is a devastating , age-specific , epileptic encephalopathy , which still presents an aetiological , pathophysiological and therapeutic problem .',
  'Sudden unexpected death in epilepsy ( SUDEP ) is a serious concern for epilepsy patients .',
  'Photosensitivity can represent a serious problem in epilepsy patients , also because pharmacologic treatment is often ineffective .',
  'Our data suggest that hyperhomocysteinemia is not a serious clinical concern in epileptic patients when folate nutriture is adequate .',
  'The estimation of Michaelis-Menten pharmacokinetic parameters in patients with epilepsy receiving phenytoin continues to be a vexing problem .',
  'Epilepsy is a neurological disorder characterized by an enduring predisposition to generate and aggravate epileptic seizures affecting around 1 % of global population making it a serious health concern .',
  'Epileptic spasms during infancy ( infantile spasms ) represent a serious treatment and social problem despite their rare occurrence .',
  'Due to their widely differentiated etiology , seizures and related conditions pose a serious diagnostic and certification problem .',
  'Aggravation of idiopathic generalized epilepsy ( IGE ) syndromes by inappropriate antiepileptic drugs ( AEDs ) is increasingly recognized as a serious and common problem .',
  'Sudden Unexpected Death in Epilepsy ( SUDEP ) has increased in awareness considerably over the last two decades and is acknowledged as a serious problem in epilepsy .',
  'Managing anti-epileptic drug treatment in adult patients with intellectual disability : a serious conundrum .',
  'Purpose . Psychiatric disorders emerging after temporal lobe resections are a serious problem threatening the surgical success of patients with epilepsy .',
  'Epilepsy was referred to as a serious medical problem with poor outcome by the Byzantine physicians .',
  'Once the diagnosis has been established , severe convulsions , often unpredictable and long-lasting , are still a major worry , but developmental and behavioural problems also rapidly become a serious concern .',
  'Generalized convulsions in the afebrile infant represent a serious and etiopathogenically very heterogeneous problem .',
  'Pharmacoresistance of AEDs in the treatment of epilepsy and psychiatric disorders is a serious problem .',
  'Childhood epilepsies are a serious and sizeable problem , and children with epilepsy have many needs .',
  'Depression in patients with epilepsy is a serious medical and social problem since it afflicts almost one half of all patients treated in epilepsy referral centers .',
  'Conditions , in which neurodevelopmental disorders are associated with the marked epileptiform EEG activity , while clinical epileptic seizures are absent , represent a serious problem .',
  'Accurate and consistent classification of cause of death among individuals with epilepsy remains a dire public health concern .',
  'Although most FS may not represent a serious health problem , those that are more prolonged and recurrent may cause hippocampal damage which is the most important pathological basis of temporal lobe epilepsy .',
  'Epilepsy represents a serious medical and social problem .'],
 'prostate': ['Prostate cancer is the most prevalent cancer in males and its incidence is steadily increasing.',
  'The etiology of benign prostatic hyperplasia and prostate cancer are unknown, with ageing being the greatness risk factor',
  'Testicular cancer is the most common malignancy in young men',
  'Prostate cancer (PCa) is a complex disease that disproportionately impacts Black men in the USA',
  'A further limitation with BPH models is that prostatic hyperplasia similar to the human condition does not occur spontaneously or can not be induced in any suitable animal species .',
  'Overdiagnosis of clinically insignificant prostate cancer is considered a major potential drawback of prostate-specific antigen ( PSA ) screening .',
  'However , a major drawback of LRPE is the transperitoneal route of access to the extraperitoneal prostate .',
  'Prolonged postoperative incontinence is a major drawback of RRP .',
  'In contemporary screening populations a major drawback of prostate specific antigen ( PSA ) is its relative lack of specificity , especially in the range of 4 to 10 ng/ml , where prostate cancer is found 25 % of the time .',
  'However , a major drawback of LRPE is the transperitoneal route of access to the extraperitoneal organ of the prostate .',
  'A major drawback of cryoablation is its lack of reliable and complete ablation of all prostate cells .',
  'Urinary incontinence after prostatectomy or radiation is a devastating problem in men and remains the most feared complication following the treatment of localized prostate cancer .',
  'Prostate cancer ( PCa ) is a serious public health concern for men worldwide .',
  'Bilateral testicular cancer : a preventable problem ? Experience from a large cancer centre .',
  'Over the past few decades it has become clear that prostate cancer is a serious health problem in elderly men .',
  'High-risk localized prostate cancer remains a vexing problem for clinicians .',
  'Chemoresistance is a serious problem for the treatment of androgen-independent prostate cancer ( PC ) .',
  'Prostate cancer is a serious public health problem that affects quality of life and has a significant mortality rate .',
  'To examine estrogen receptor-beta ( ERbeta ) expression in prostate cancer ( CaP ) metastases , thereby providing a basis for conducting estrogen therapy studies in patients with metastatic CaP. Advanced androgen-independent CaP is a serious health problem with no effective treatment at present .',
  'Patients with negative prostate biopsy and persistent suspicion of prostate cancer ( PCa ) can pose a serious diagnostic problem .',
  "Lack of efficient noninvasive biomarkers for differentiating prostate cancer ( PCa ) and benign prostate hyperplasia ( BPH ) is a serious concern for men 's health worldwide .",
  'Urinary complications resulting from benign prostatic hyperplasia and bladder outlet obstruction continue to be a serious health problem .',
  'Management of prostate cancer that either is detectable by prostate specific antigen ( PSA ) measurements after curative intent or has spread outside of its capsule is a serious problem .',
  'Currently , a drug-induced metabolic syndrome related with androgen deprivation therapy in patients with prostate cancer represents a serious medical problem .',
  'Prostate cancer is a serious health care problem in the United States .',
  'As a serious health problem that is increasing in severity , cancer in black men deserves close attention and definitive action .',
  'Prostate carcinoma ( PCa ) is the most common male cancer in industrialized societies and represents a serious public health problem .',
  'Prostate cancer is a serious health problem in the Caribbean with high incidence and mortality rates affecting a predominantly Black population .',
  'Prostate cancer represents a serious health problem worldwide .',
  'Anastomotic strictures ( AS ) are uncommon but a vexing problem after radical prostatectomy .',
  'Prostate cancer ( PC ) is a serious health problem all over the world .',
  'Local recurrence ( LR ) of prostate cancer after external beam radiotherapy ( EBRT ) is a serious problem .',
  'Metastatic prostate cancer is a life-threatening disease and an important public health concern with prevalence rates varying drastically between high- and low-income countries .',
  'In contrast to urinary continence , erectile dysfunction is still a serious concern for patients who undergo radical prostatectomy .',
  'The need for an early and accurate detection is thus a great challenge in common clinical practice , but the lack of specificity of the serum marker PSA ( Prostate Specific Antigen ) is a serious problem since its increased concentration can be related to several abnormalities .',
  'While severe urinary dysfunction is rare , sexual impairment remains a serious concern after rectal resection with TME .',
  'The high incidence and subsequent mortality from prostate cancer in progressively older US males is a serious health concern .',
  'Decreased participation in prostate cancer screening by African American men is a serious problem , as decreased survival rates occur when the diagnosis of prostate cancer is delayed .',
  'Prostate cancer ( PC ) is a serious public health problem in the United States , especially in African-American men ( AAs ) .',
  'Prostate cancer is a serious public health problem in many industrialized countries .',
  'Castration resistance is a serious problem facing clinical treatment of prostate cancer ( PCa ) .',
  'Urinary incontinence post retropubic " anatomical " radical prostatectomy remains a distressing problem for the patient and the physician rating from 6 to 20 % even in the hands of experienced surgeons from high volume Academic Centers .',
  'Bilateral testicular cancer : a preventable problem ? Experience from a large cancer centre .',
  'Accurate and consistent discrimination of prostatic carcinomas from benign lesions and vice versa continues to be a vexing problem in diagnostic pathology .',
  'Insensitivity of advanced-stage prostate cancer to androgen ablation therapy is a serious problem in clinical practice because it is associated with aggressive progression and poor prognosis .',
  'Aging of population in Macau has become a serious problem and we are diagnosing more and more patients with prostate cancer .',
  'Metastatic castration-resistant prostate cancer poses a serious clinical problem with poor outcomes and remains a deadly disease .',
  'Due to its prevalence , prostate cancer represents a serious health problem .',
  'The progression of prostate cancer during androgen deprivation therapy is a serious clinical problem .',
  'Hormonal therapy is the mainstay of therapy , however castration-resistant prostate cancer ( CRPC ) becomes a serious problem and needs further clinical trials with novel agents .',
  'Since the surgical technique does not seem to be the factor responsible for such a serious problem , more accentuated by the fact that this operation is becoming increasingly frequent with the increase in life expectancy , an assessment of 15 patients before and after prostatectomy is presented .',
  'Urinary incontinence after radical prostatectomy continues to be a distressing problem , even with preservation of the neurovascular bundles and meticulous apical dissection .'],
 'pca': ['Prostate cancer is the most prevalent cancer in males and its incidence is steadily increasing.',
  'The etiology of benign prostatic hyperplasia and prostate cancer are unknown, with ageing being the greatness risk factor',
  'Testicular cancer is the most common malignancy in young men',
  'Prostate cancer (PCa) is a complex disease that disproportionately impacts Black men in the USA',
  'A further limitation with BPH models is that prostatic hyperplasia similar to the human condition does not occur spontaneously or can not be induced in any suitable animal species .',
  'Overdiagnosis of clinically insignificant prostate cancer is considered a major potential drawback of prostate-specific antigen ( PSA ) screening .',
  'In contemporary screening populations a major drawback of prostate specific antigen ( PSA ) is its relative lack of specificity , especially in the range of 4 to 10 ng/ml , where prostate cancer is found 25 % of the time .',
  'A major drawback of cryoablation is its lack of reliable and complete ablation of all prostate cells .',
  'Prostate cancer ( PCa ) is a serious public health concern for men worldwide .',
  'Bilateral testicular cancer : a preventable problem ? Experience from a large cancer centre .',
  'Over the past few decades it has become clear that prostate cancer is a serious health problem in elderly men .',
  'High-risk localized prostate cancer remains a vexing problem for clinicians .',
  'Chemoresistance is a serious problem for the treatment of androgen-independent prostate cancer ( PC ) .',
  'Prostate cancer is a serious public health problem that affects quality of life and has a significant mortality rate .',
  'To examine estrogen receptor-beta ( ERbeta ) expression in prostate cancer ( CaP ) metastases , thereby providing a basis for conducting estrogen therapy studies in patients with metastatic CaP. Advanced androgen-independent CaP is a serious health problem with no effective treatment at present .',
  'Patients with negative prostate biopsy and persistent suspicion of prostate cancer ( PCa ) can pose a serious diagnostic problem .',
  "Lack of efficient noninvasive biomarkers for differentiating prostate cancer ( PCa ) and benign prostate hyperplasia ( BPH ) is a serious concern for men 's health worldwide .",
  'Management of prostate cancer that either is detectable by prostate specific antigen ( PSA ) measurements after curative intent or has spread outside of its capsule is a serious problem .',
  'Currently , a drug-induced metabolic syndrome related with androgen deprivation therapy in patients with prostate cancer represents a serious medical problem .',
  'Prostate cancer is a serious health care problem in the United States .',
  'As a serious health problem that is increasing in severity , cancer in black men deserves close attention and definitive action .',
  'Prostate carcinoma ( PCa ) is the most common male cancer in industrialized societies and represents a serious public health problem .',
  'Prostate cancer is a serious health problem in the Caribbean with high incidence and mortality rates affecting a predominantly Black population .',
  'Prostate cancer represents a serious health problem worldwide .',
  'Prostate cancer ( PC ) is a serious health problem all over the world .',
  'Local recurrence ( LR ) of prostate cancer after external beam radiotherapy ( EBRT ) is a serious problem .',
  'Metastatic prostate cancer is a life-threatening disease and an important public health concern with prevalence rates varying drastically between high- and low-income countries .',
  'The need for an early and accurate detection is thus a great challenge in common clinical practice , but the lack of specificity of the serum marker PSA ( Prostate Specific Antigen ) is a serious problem since its increased concentration can be related to several abnormalities .',
  'The high incidence and subsequent mortality from prostate cancer in progressively older US males is a serious health concern .',
  'Decreased participation in prostate cancer screening by African American men is a serious problem , as decreased survival rates occur when the diagnosis of prostate cancer is delayed .',
  'Prostate cancer ( PC ) is a serious public health problem in the United States , especially in African-American men ( AAs ) .',
  'Prostate cancer is a serious public health problem in many industrialized countries .',
  'Castration resistance is a serious problem facing clinical treatment of prostate cancer ( PCa ) .',
  'Bilateral testicular cancer : a preventable problem ? Experience from a large cancer centre .',
  'Accurate and consistent discrimination of prostatic carcinomas from benign lesions and vice versa continues to be a vexing problem in diagnostic pathology .',
  'Insensitivity of advanced-stage prostate cancer to androgen ablation therapy is a serious problem in clinical practice because it is associated with aggressive progression and poor prognosis .',
  'Aging of population in Macau has become a serious problem and we are diagnosing more and more patients with prostate cancer .',
  'Metastatic castration-resistant prostate cancer poses a serious clinical problem with poor outcomes and remains a deadly disease .',
  'Due to its prevalence , prostate cancer represents a serious health problem .',
  'The progression of prostate cancer during androgen deprivation therapy is a serious clinical problem .',
  'Hormonal therapy is the mainstay of therapy , however castration-resistant prostate cancer ( CRPC ) becomes a serious problem and needs further clinical trials with novel agents .'],
 'androgen': ['Prostate cancer is the most prevalent cancer in males and its incidence is steadily increasing.',
  'The etiology of benign prostatic hyperplasia and prostate cancer are unknown, with ageing being the greatness risk factor',
  'Testicular cancer is the most common malignancy in young men',
  'Prostate cancer (PCa) is a complex disease that disproportionately impacts Black men in the USA',
  'A further limitation with BPH models is that prostatic hyperplasia similar to the human condition does not occur spontaneously or can not be induced in any suitable animal species .',
  'Overdiagnosis of clinically insignificant prostate cancer is considered a major potential drawback of prostate-specific antigen ( PSA ) screening .',
  'In contemporary screening populations a major drawback of prostate specific antigen ( PSA ) is its relative lack of specificity , especially in the range of 4 to 10 ng/ml , where prostate cancer is found 25 % of the time .',
  'A major drawback of cryoablation is its lack of reliable and complete ablation of all prostate cells .',
  'Prostate cancer ( PCa ) is a serious public health concern for men worldwide .',
  'Bilateral testicular cancer : a preventable problem ? Experience from a large cancer centre .',
  'Over the past few decades it has become clear that prostate cancer is a serious health problem in elderly men .',
  'High-risk localized prostate cancer remains a vexing problem for clinicians .',
  'Chemoresistance is a serious problem for the treatment of androgen-independent prostate cancer ( PC ) .',
  'Prostate cancer is a serious public health problem that affects quality of life and has a significant mortality rate .',
  'To examine estrogen receptor-beta ( ERbeta ) expression in prostate cancer ( CaP ) metastases , thereby providing a basis for conducting estrogen therapy studies in patients with metastatic CaP. Advanced androgen-independent CaP is a serious health problem with no effective treatment at present .',
  'Patients with negative prostate biopsy and persistent suspicion of prostate cancer ( PCa ) can pose a serious diagnostic problem .',
  "Lack of efficient noninvasive biomarkers for differentiating prostate cancer ( PCa ) and benign prostate hyperplasia ( BPH ) is a serious concern for men 's health worldwide .",
  'Management of prostate cancer that either is detectable by prostate specific antigen ( PSA ) measurements after curative intent or has spread outside of its capsule is a serious problem .',
  'Currently , a drug-induced metabolic syndrome related with androgen deprivation therapy in patients with prostate cancer represents a serious medical problem .',
  'Prostate cancer is a serious health care problem in the United States .',
  'As a serious health problem that is increasing in severity , cancer in black men deserves close attention and definitive action .',
  'Prostate carcinoma ( PCa ) is the most common male cancer in industrialized societies and represents a serious public health problem .',
  'Prostate cancer is a serious health problem in the Caribbean with high incidence and mortality rates affecting a predominantly Black population .',
  'Prostate cancer represents a serious health problem worldwide .',
  'Prostate cancer ( PC ) is a serious health problem all over the world .',
  'Local recurrence ( LR ) of prostate cancer after external beam radiotherapy ( EBRT ) is a serious problem .',
  'Metastatic prostate cancer is a life-threatening disease and an important public health concern with prevalence rates varying drastically between high- and low-income countries .',
  'The need for an early and accurate detection is thus a great challenge in common clinical practice , but the lack of specificity of the serum marker PSA ( Prostate Specific Antigen ) is a serious problem since its increased concentration can be related to several abnormalities .',
  'The high incidence and subsequent mortality from prostate cancer in progressively older US males is a serious health concern .',
  'Decreased participation in prostate cancer screening by African American men is a serious problem , as decreased survival rates occur when the diagnosis of prostate cancer is delayed .',
  'Prostate cancer ( PC ) is a serious public health problem in the United States , especially in African-American men ( AAs ) .',
  'Prostate cancer is a serious public health problem in many industrialized countries .',
  'Castration resistance is a serious problem facing clinical treatment of prostate cancer ( PCa ) .',
  'Bilateral testicular cancer : a preventable problem ? Experience from a large cancer centre .',
  'Accurate and consistent discrimination of prostatic carcinomas from benign lesions and vice versa continues to be a vexing problem in diagnostic pathology .',
  'Insensitivity of advanced-stage prostate cancer to androgen ablation therapy is a serious problem in clinical practice because it is associated with aggressive progression and poor prognosis .',
  'Aging of population in Macau has become a serious problem and we are diagnosing more and more patients with prostate cancer .',
  'Metastatic castration-resistant prostate cancer poses a serious clinical problem with poor outcomes and remains a deadly disease .',
  'Due to its prevalence , prostate cancer represents a serious health problem .',
  'The progression of prostate cancer during androgen deprivation therapy is a serious clinical problem .',
  'Hormonal therapy is the mainstay of therapy , however castration-resistant prostate cancer ( CRPC ) becomes a serious problem and needs further clinical trials with novel agents .'],
 'sepsis': ['Trying to differentiate serious bacterial infection (SBI) from a self-limiting illness in febrile infants seen in the pediatric emergency department (PED) is a significant challenge.',
  'Sepsis is a syndrome of life-threatening organ dysfunction caused by a dysregulated host response to infection',
  'A potential drawback of neutrophils is their high intrinsic serine protease activity , which necessitates the use of very potent protease inhibitors such as the organophosphorus neurotoxin diisopropylfluorophosphate ( DIFP ) as part of the lysis buffer .',
  'Accordingly , the infiltration of different tissues by macrophages and the inflammatory local and systemic effects observed in ECD likely represent a drawback of OIS .',
  'Infectious disease and sepsis represent a serious problem for all , but especially in early life .',
  'Septic shock is often associated with acute respiratory distress syndrome , a serious clinical problem exacerbated by improper mechanical ventilation .',
  'Sepsis is not only a threat to the health of individual patients but also presents a serious epidemiological problem .',
  'The high rate of community-acquired resistant sepsis-especially that caused by Klebsiella spp . and S aureus-is a serious global public health concern .',
  'A serious problem during intensive care and nursing of premature infants is the invasiveness of many examination methods .',
  'Septic shock is a serious problem in critically ill and surgical patients throughout the world .',
  'Sepsis is a devastating problem that has eluded a solution , despite the introduction of highly effective antimicrobial agents .',
  'Nosocomial sepsis is a serious problem for neonates who are admitted for intensive care .',
  'Sepsis is a serious clinical problem .',
  'Sepsis , a serious clinical problem , is characterized by a systemic inflammatory response to infection and leads to organ failure .',
  'Sepsis is a serious clinical problem which arises due to the excessive host inflammatory response to infection .',
  'Delayed diagnosis of congenital tuberculosis ( TB ) in the neonatal intensive care unit ( NICU ) is a serious problem in terms of infection control .',
  'Polymicrobial infections remain a serious clinical problem , and in the hospital , sepsis is the number-one noncardiac killer .',
  'Sepsis remains a serious clinical problem despite intense efforts to improve survival .',
  'Sepsis is a serious problem in intensive care units all over the world .',
  "Sepsis is the body 's systemic response to infection and is a serious health care concern that affects neonatal , pediatric , and adult populations worldwide .",
  'Catabolism is a serious problem in patients with active inflammation .',
  'Sepsis , severe sepsis , and septic shock represent a serious medicinal and general social problem and still maintain an important position among the present issues in the basic and clinical research .',
  'Systemic inflammation resulting from bacterial infection can lead to sepsis , which remains a serious problem with high mortality rates .',
  'These findings resemble those seen in necrotizing enterocolitis of premature babies , a serious intestinal problem in the neonate .',
  'Perinatal infections are the leading cause of severe congenital pathology , a serious worldwide medical and social problem that needs to be addressed .',
  'Sepsis is a serious clinical problem involving complex mechanisms which requires better understanding and insight .',
  'BACKGROUND Sepsis is a serious clinical problem that results from the systemic response of the body to infection .',
  'Bacterial sepsis is a life-threatening disease and a significant clinical problem caused by host responses to a microbial infection .',
  'Neonatal sepsis remains a serious problem in any neonatal intensive care unit ( NICU ) .',
  'Sepsis , a life-threatening organ dysfunction caused by infection , is a major public health concern with limited therapeutic options .',
  'Sepsis remains a serious clinical problem despite continuous efforts to increase survival .',
  'Hypotension is a serious problem in septic patients .',
  'Sepsis is a serious global health problem .',
  'Nosocomial sepsis is a serious problem for neonates who are admitted for intensive care .',
  'Sepsis is still a severe health problem worldwide with high morbidity and mortality .',
  'Sepsis is a serious and growing health problem among patients admitted to intensive care units .',
  'Sepsis , a life-threatening organ dysfunction caused by a dysregulated response to infection is a major public health concern , as it is a leading cause of mortality and critical illness worldwide .',
  'Despite its existence since the time of Hippocrates ( 470 \xa0 BC ) , sepsis is still a serious medical problem for physicians working in both pediatric and adult intensive care units .',
  'Pediatric disease is atypical in developed regions but remains a serious concern in resource-limited areas where infection occurs commonly at birth and through breast feeding .',
  'The heart is one of the target organs susceptible to attack by sepsis , and protection of the cardiac function in sepsis or alleviation dysfunction caused by sepsis appears a serious and urgent problem .',
  'Sepsis has always been a severe clinical problem in critical care medicine due to its rather high mortality and poor prognosis .',
  'Nevertheless , objective parameters to establish a pathological correlate of a fatal outcome are lacking ; then a cause of death due to sepsis can remain an unsolved problem .',
  'Serratia marcescens septicemia represents a serious problem in high risk critical care patients .',
  'Sepsis remains a serious clinical problem because of high patient morbidity and mortality .',
  'Despite this success , severe sepsis remains a serious health care problem .',
  'Sepsis remains a serious clinical problem despite intense efforts to improve survival .',
  'Introduction In developing countries , sepsis and associated mortality rates in neonatal patients is a serious concern .',
  'However , most infections are asymptomatic , indicating that CMV infection in preterm infants within such a population is a serious problem infrequently .',
  'Gram-negative sepsis/septic shock in the human newborn continues to be a severe medical problem because of significant mortality and morbidity .',
  'In these patients , Gramnegative sepsis , the symptoms of which are predominantly caused by LPS-induced release of monokines , represents a serious problem .',
  'Sepsis is a serious and increasing worldwide intensive care problem .',
  'Sepsis , otherwise referred to as " blood poisoning " is a serious clinical problem , the incidence of which continues to rise in the US and worldwide despite advances in antimicrobial chemotherapy .',
  'Sepsis is a serious health problem in the elderly with a high degree of mortality .',
  'Neonatal infection is a serious public health problem .',
  'Nosocomial infections are a serious problem among very low birth weight ( VLBW ) infants .',
  'Candidal infections are a serious problem in neonatal intensive care units , increasing morbidity and mortality in low birth weight infants in addition to escalating health-care costs .',
  'Because relevant models must mimic a severe and chronic syndrome , animal well-being is often a concern in sepsis research .',
  'Sepsis remains a serious clinical problem despite intensive research efforts and numerous attempts to improve outcome by modifying the inflammatory response .',
  'Septicemia is a serious problem in hemodialysis patients because it can lead to life-threatening complications and a persistently elevated risk of death .',
  'Sepsis remains a serious problem in critically ill patients with the mortality increasing to over half when there is attendant acute kidney injury .',
  'Newborns with gastroschisis despite progress in prenatal diagnostics , neonatal intensive care and surgical methods remains a serious therapeutic problem requiring multidisciplinary care and long-standing hospital stay .',
  'VKDB , a preventable cause of life-threatening hemorrhage , is still a major health problem in Egyptian infants , where persistent diarrhea and misuse of antibiotics are prevalent , necessitate a booster dose of VK in those high risk infants .',
  'Septic shock continues to be a serious problem with a mortality ranging from 11 % to 82 % , depending upon the cause , the time of diagnosis , and the type of treatment .',
  'Sepsis-induced cardiac dysfunction is a severe clinical problem .',
  'Catabolism is a serious clinical problem in patients with active inflammation .',
  'Sepsis is a preventable public health problem .',
  'Once introduced , RV appears to become a troublesome problem of HA infections in neonatal care settings .',
  'Sepsis and septic shock are a serious problem , particularly in the geriatric population .',
  'To solve such a serious problem , a dual magnetoimmunosensor is proposed for simultaneous assessment of two of the most important sepsis biomarkers : procalcitonin ( PCT for early phase ) and C-reactive protein ( CRP for late phase ) .',
  'Sepsis has been become a serious problem waiting to be solved urgently no matter in the fields of trauma , or in intensive care and infection , etc .',
  'Sepsis is a threatening health problem and characterized by microvascular dysfunction .',
  'Septic shock can be a devastating management problem during pregnancy .',
  'Sepsis is a serious clinical problem and estimated to be responsible for 18 million annual deaths worldwide .',
  'Sepsis resulting from microbial colonization of the bloodstream is a serious health concern associated with high mortality rates .',
  'Advances in neonatal care have led to the increasing survival of smaller and sicker infants , but nosocomial infections continue to be a serious problem , associated with increased mortality rates , immediate and long-term morbidity , prolonged hospital stay , and increased cost of care .',
  'Background Nosocomial infections are a serious problem in the treatment of extremely low birth weight infants ( ELBW , < 1 \u2009',
  'Sepsis-induced myocardial dysfunction is a severe clinical problem .',
  'Neonatal late-onset sepsis ( LOS ) is a serious problem in neonatal intensive care .',
  'Sepsis is a syndrome caused by uncontrolled systemic inflammatory response of the individual , which represents a serious epidemiological problem worldwide .',
  'Sepsis remains a serious clinical problem , and multiple attempts at blocking inflammation have failed to decrease mortality rate .',
  'Early diagnosis of neonatal septicemia is a vexing problem because of its non-specific clinical picture .',
  'Recurrent infection that can progress to life-threatening renal failure has remained as a serious global health concern in infants .',
  'Necrotizing enterocolitis ( NEC ) is a serious problem in nurseries for premature infants and neonatal intensive care units , with a high incidence of morbidity and mortality .',
  'We are interested in how and why anaesthetics increase infections in intensive care patients ; a serious problem as more than 50 % of patients with severe sepsis will die .',
  'Sepsis , a life-threatening organ dysfunction caused by a dysregulated host response to infection , is a major public health concern with high mortality and morbidity .',
  'Sepsis occurring in the first week of life can be a devastating neonatal problem .',
  'Gastrointestinal tract perforation in neonates is a serious problem associated with high morbidity and mortality .',
  'Bacterial infection remains a serious problem in neonatal intensive care .',
  'Fungemia is a serious problem within neonatal intensive care units around the world .',
  'Infections represent a serious health problem in neonates .',
  'Sepsis is a systemic inflammatory response to infection eliciting high mortality rate which is a serious health problem .',
  'Early onset sepsis ( EOS ) is a severe problem affecting very low birth weight ( VLBW ) infants and is associated with a threefold increased risk of mortality .',
  'Sepsis is a serious problem among the geriatric population as its incidence and mortality rates dramatically increase with advanced age .',
  'Neonatal early-onset sepsis is a serious health concern for term and late preterm infants .',
  'Endothelial barrier dysfunction , which is a serious problem that occurs in various inflammatory conditions , permits extravasation of serum components into the surrounding tissues , leading to edema formation and organ failure .',
  'Health care-associated infection ( HCAI ) is a serious problem of neonatal intensive care units ( NICUs ) which is related to morbidity , mortality and increased cost of medical care .',
  'Microvascular barrier dysfunction is a serious problem that occurs in many inflammatory conditions , including sepsis , trauma , ischemia-reperfusion injury , cardiovascular disease , and diabetes .',
  'Although neutropenia is manageable in most situations , it remains a serious problem that , at its worst , can progress to life-threatening septicemia .',
  'Invasiveness of examination and therapy methods is a serious problem for intensive care and nursing of premature infants .',
  'Sepsis , as a severe systemic inflammatory response to bacterial infection , represents a major clinical problem .',
  'Sepsis is the leading cause of death in medical intensive care units , and thus represents a serious healthcare problem worldwide .',
  'Muscle weakness in septic patients is a serious problem as it complicates and lengthens hospital stays , prolongs rehabilitation and increases costs .',
  'Biliary tract infection (BTI)-derived sepsis remains a serious problem with significant morbidity and mortality in the modern era of critical care management .',
  'Sepsis remains a serious clinical problem despite intense efforts to improve survival .',
  'Sepsis is a serious health problem associated with a range of infectious diseases in animals and humans .',
  'Gastro-intestinal tract ( GIT ) perforation in neonates is a serious problem associated with high mortality due to resulting sepsis .',
  'Sepsis is a severe public health problem affecting millions of individuals , with global mortality rates caused by lower respiratory tract infections are approximately 2.38 million people a year die from respiratory failure caused by infection .',
  'Sepsis remains a serious clinical problem because of high morbidity and mortality .',
  'Sepsis poses a serious global health problem with an overall mortality rate of 30 % , in which the vascular injury is a major contributor .',
  'Sepsis is a serious , life-threatening condition that presents a growing problem in medicine , but there is still no satisfying solution for treating it .',
  'Despite recent progress in critical care , sepsis remains a serious problem with high rate of mortality .',
  'Catheter sepsis has become a serious problem due to increased use of parenteral nutrition .',
  'Sepsis is a serious medical problem and is one of the main causes of high mortality in intensive care units .',
  "Serious infection and the patient 's response ( sepsis ) is a serious health problem that , even today , is associated with a mortality rate of 30 \xa0 % -50 \xa0 % .",
  'Inflammatory shock as a consequence of LPS release remains a serious clinical concern .'],
 'colorectal': ['In metastatic colorectal cancer, no upfront or on-treatment markers are available to determine the prognosis or efficacy for chemotherapy in combination with bevacizumab.',
  'Colon cancer is the third most deadly and one of the most diagnosed diseases in the world',
  'Colorectal cancer is one leading cause of cancer-related morbidity and mortality',
  'Refusal of colonoscopy is a drawback of colorectal cancer screening programmes based on faecal occult blood test .',
  'Polyp miss-rate is a drawback of colonoscopy that increases significantly for small polyps .',
  'The high frequency of local recurrence occurring after endoscopic piecemeal resection ( EPMR ) for large colorectal tumors is a serious problem .',
  'However , CD-DST is often a culture method , and contamination is a serious problem , especially in the case of colorectal cancer , which is contaminated by enteric bacteria .',
  'Nevertheless recurrent rectal carcinoma remains a severe problem .',
  'Colon cancer ( CRC ) is a serious health problem through worldwide .',
  'Colorectal cancer is one of the most common cancer types worldwide and it continues to be a serious public health problem .',
  'Colorectal cancer ( CRC ) represents a serious and growing health problem in Canada .',
  'Despite that colorectal cancer ( CRC ) is a severe global health problem , effective chemopreventive strategies against CRC are still lacking .',
  'Colorectal cancer remains a serious public health problem due to the poor prognosis .',
  'The spread of intra-abdominal cancers is a vexing clinical problem for which there is no widely effective treatment .',
  'Colorectal cancer ( CRC ) is a severe health problem worldwide .',
  'Colorectal cancer is a serious medical problem in Taiwan .',
  'The high prevalence of type 2 diabetes mellitus ( DM ) among patients with colorectal cancer ( CRC ) is becoming a serious public health concern worldwide .',
  'Life quality of the patients operated from rectal cancer is a serious problem .',
  'Because of its frequency , colorectal cancer represents a serious problem for public health .',
  'Colorectal cancer ( CRC ) is a serious public health problem and non-invasive biomarkers improving diagnosis or therapy are strongly required .',
  'As colorectal cancer and colorectal liver metastases become a serious public health problem , new treatment modalities are needed in order to achieve better results .',
  'When SEMS are used for patients in the terminal stage with obstruction due to colorectal cancer , re-obstruction is a severe problem .',
  'Colorectal cancer ( CRC ) is a serious health problem , and various screening programs to reduce CRC have been introduced worldwide .',
  'Colorectal cancer constitutes a serious health care problem in the Western world due to its frequency and mortality .',
  'Colon cancer has a high prevalence worldwide and is a serious public health problem .',
  'Colorectal cancer is a serious medical problem .',
  'Colorectal cancer is a serious health problem in which screening is capable of reducing both the mortality and the incidence of the disorder .',
  'Pelvic recurrence occurs in 4 - 33 % of patients who have undergone a curative resection of primary rectal cancer and is thus a serious problem .',
  'The incidence of colorectal cancer has increased in Iran in the past three decades and is now considered as a serious problem for our society .',
  'Colorectal cancer ( CRC ) is a serious public health problem that results due to changes of diet and various environmental stress factors in the world .',
  'Colorectal cancer ( CRC ) is a serious medical and economical problem of our times .',
  'Colorectal cancer ( CRC ) is a serious health problem throughout the world .',
  'Colorectal cancer is a serious medical and economic problem in Poland , as the detection and results of its treatment are very low .',
  'Disseminated colon carcinoma metastases in the liver are associated with low cure rates and constitute a serious therapeutic problem .',
  'Colorectal cancer ( CRC ) remains a serious health problem worldwide .',
  'Colorectal carcinoma presents a serious problem in the Czech Republic : its incidence is on the increase and -- according to some statistics takes first place among developed countries worldwide .',
  "Colorectal cancer that develops as a complication of ulcerative colitis ( UC ) is a serious problem that affects the patient 's prognosis .",
  'Colon cancer ( CRC ) is a serious health problem throughout the world .',
  'Malignant bowel obstruction ( MBO ) , a serious problem in stage IV colorectal cancer ( CRC ) patients , remains poorly understood .',
  'However , distant metastasis is still a serious problem after seemingly curative resection in patients with rectal cancer .',
  'Metastatic colorectal cancer remains a serious health concern with poor patient survival .',
  'Enteric stoma is a serious health , as well as life problem .',
  'Colorectal cancer represents a serious public-health problem in the United States , with important geographic differences and disparities of care evident in its detection and treatment .',
  'The colorectal cancer is a serious health problem .',
  'Colorectal cancer ( CRC ) remains a serious health concern worldwide .',
  'Colon cancer is a serious health problem , and novel preventive and therapeutical avenues are urgently called for .',
  'Colonic neoplasms are quite a serious problem today .',
  'Abnormal and rapid proliferation of colon cancer cells is a severe problem that can be regulated by non-coding RNAs .',
  'Colorectal neoplasms present a serious diagnostic and therapeutic problem .',
  'Colorectal cancer ( CRC ) is a serious public health problem due to its high frequency and the mortality it provokes .',
  'Colorectal cancer ( CRC ) poses a serious health problem worldwide .',
  'Colorectal cancer is a serious health problem .',
  'Colon cancer remains as a serious health problem around the world despite advances in diagnosis and treatment .',
  'Colorectal cancer has become a serious problem , especially in highly developed countries .',
  'In the Medimurje County , colorectal cancer ( CRC ) poses a serious health problem .',
  'Liver metastases present a serious problem in the therapy of advanced colorectal cancer ( CRC ) , as more than 20 % of patients have distant metastases at the time of diagnosis with less than 5 % being cured .',
  'Colorectal cancer ( CRC ) represents a serious health care problem in the Czech Republic , introducing a need for a prospective modelling of the incidence and prevalence rates .',
  'Colorectal cancer is a serious health problem , a challenge for research , and a model for studying the molecular mechanisms involved in its development .',
  'Colorectal cancer ( CRC ) is still a fatal health problem around the world .'],
 'colon': ['In metastatic colorectal cancer, no upfront or on-treatment markers are available to determine the prognosis or efficacy for chemotherapy in combination with bevacizumab.',
  'Colon cancer is the third most deadly and one of the most diagnosed diseases in the world',
  'Colorectal cancer is one leading cause of cancer-related morbidity and mortality',
  'Refusal of colonoscopy is a drawback of colorectal cancer screening programmes based on faecal occult blood test .',
  'Polyp miss-rate is a drawback of colonoscopy that increases significantly for small polyps .',
  'The high frequency of local recurrence occurring after endoscopic piecemeal resection ( EPMR ) for large colorectal tumors is a serious problem .',
  'However , CD-DST is often a culture method , and contamination is a serious problem , especially in the case of colorectal cancer , which is contaminated by enteric bacteria .',
  'Nevertheless recurrent rectal carcinoma remains a severe problem .',
  'Colon cancer ( CRC ) is a serious health problem through worldwide .',
  'Colorectal cancer is one of the most common cancer types worldwide and it continues to be a serious public health problem .',
  'Colorectal cancer ( CRC ) represents a serious and growing health problem in Canada .',
  'Despite that colorectal cancer ( CRC ) is a severe global health problem , effective chemopreventive strategies against CRC are still lacking .',
  'Colorectal cancer remains a serious public health problem due to the poor prognosis .',
  'The spread of intra-abdominal cancers is a vexing clinical problem for which there is no widely effective treatment .',
  'Colorectal cancer ( CRC ) is a severe health problem worldwide .',
  'Colorectal cancer is a serious medical problem in Taiwan .',
  'The high prevalence of type 2 diabetes mellitus ( DM ) among patients with colorectal cancer ( CRC ) is becoming a serious public health concern worldwide .',
  'Life quality of the patients operated from rectal cancer is a serious problem .',
  'Because of its frequency , colorectal cancer represents a serious problem for public health .',
  'Colorectal cancer ( CRC ) is a serious public health problem and non-invasive biomarkers improving diagnosis or therapy are strongly required .',
  'As colorectal cancer and colorectal liver metastases become a serious public health problem , new treatment modalities are needed in order to achieve better results .',
  'When SEMS are used for patients in the terminal stage with obstruction due to colorectal cancer , re-obstruction is a severe problem .',
  'Colorectal cancer ( CRC ) is a serious health problem , and various screening programs to reduce CRC have been introduced worldwide .',
  'Colorectal cancer constitutes a serious health care problem in the Western world due to its frequency and mortality .',
  'Colon cancer has a high prevalence worldwide and is a serious public health problem .',
  'Colorectal cancer is a serious medical problem .',
  'Colorectal cancer is a serious health problem in which screening is capable of reducing both the mortality and the incidence of the disorder .',
  'Pelvic recurrence occurs in 4 - 33 % of patients who have undergone a curative resection of primary rectal cancer and is thus a serious problem .',
  'The incidence of colorectal cancer has increased in Iran in the past three decades and is now considered as a serious problem for our society .',
  'Colorectal cancer ( CRC ) is a serious public health problem that results due to changes of diet and various environmental stress factors in the world .',
  'Colorectal cancer ( CRC ) is a serious medical and economical problem of our times .',
  'Colorectal cancer ( CRC ) is a serious health problem throughout the world .',
  'Colorectal cancer is a serious medical and economic problem in Poland , as the detection and results of its treatment are very low .',
  'Disseminated colon carcinoma metastases in the liver are associated with low cure rates and constitute a serious therapeutic problem .',
  'Colorectal cancer ( CRC ) remains a serious health problem worldwide .',
  'Colorectal carcinoma presents a serious problem in the Czech Republic : its incidence is on the increase and -- according to some statistics takes first place among developed countries worldwide .',
  "Colorectal cancer that develops as a complication of ulcerative colitis ( UC ) is a serious problem that affects the patient 's prognosis .",
  'Colon cancer ( CRC ) is a serious health problem throughout the world .',
  'Malignant bowel obstruction ( MBO ) , a serious problem in stage IV colorectal cancer ( CRC ) patients , remains poorly understood .',
  'However , distant metastasis is still a serious problem after seemingly curative resection in patients with rectal cancer .',
  'Metastatic colorectal cancer remains a serious health concern with poor patient survival .',
  'Enteric stoma is a serious health , as well as life problem .',
  'Colorectal cancer represents a serious public-health problem in the United States , with important geographic differences and disparities of care evident in its detection and treatment .',
  'The colorectal cancer is a serious health problem .',
  'Colorectal cancer ( CRC ) remains a serious health concern worldwide .',
  'Colon cancer is a serious health problem , and novel preventive and therapeutical avenues are urgently called for .',
  'Colonic neoplasms are quite a serious problem today .',
  'Abnormal and rapid proliferation of colon cancer cells is a severe problem that can be regulated by non-coding RNAs .',
  'Colorectal neoplasms present a serious diagnostic and therapeutic problem .',
  'Colorectal cancer ( CRC ) is a serious public health problem due to its high frequency and the mortality it provokes .',
  'Colorectal cancer ( CRC ) poses a serious health problem worldwide .',
  'Colorectal cancer is a serious health problem .',
  'Colon cancer remains as a serious health problem around the world despite advances in diagnosis and treatment .',
  'Colorectal cancer has become a serious problem , especially in highly developed countries .',
  'In the Medimurje County , colorectal cancer ( CRC ) poses a serious health problem .',
  'Liver metastases present a serious problem in the therapy of advanced colorectal cancer ( CRC ) , as more than 20 % of patients have distant metastases at the time of diagnosis with less than 5 % being cured .',
  'Colorectal cancer ( CRC ) represents a serious health care problem in the Czech Republic , introducing a need for a prospective modelling of the incidence and prevalence rates .',
  'Colorectal cancer is a serious health problem , a challenge for research , and a model for studying the molecular mechanisms involved in its development .',
  'Colorectal cancer ( CRC ) is still a fatal health problem around the world .'],
 'maltreatment': ['Orphans and other vulnerable children (OVC) who grow up in institutional care often show communication and language problems.',
  'The problem with boarding out is that it was a measure in response to widely varying situations , not only in respect of the illegitimate as well as the legitimate children concerned , but also with regard to the reasons which led to boarding out . Orphans after the First World War with no relatives who could take them in formed a minority , and in several Swiss cantons the legitimate children outnumbered the illegitimate ones by far .',
  'Child maltreatment is a serious and preventable public health problem .',
  'The findings confirm that child abuse perpetuated by parents is a serious problem in Mainland China , especially among migrant families , and implications for policy and practice are discussed .',
  'Child abduction is a serious problem ; therefore , it is essential that researchers evaluate the efficacy of commercially available abduction-prevention programs .',
  'Child maltreatment ( CM ) constitutes a serious public health problem in the United States with parents implicated in a majority of physical abuse and neglect cases .',
  'Physical abuse of children is a severe social problem and is usually identified by the presence of bruises of various ages .',
  'Child abuse and neglect is a serious social problem with global dimensions .',
  'Placement instability remains a vexing problem for child welfare agencies across the country .',
  'Parental kidnapping has become a serious concern in the United States .',
  'Child maltreatment is a serious public health concern in the United States .',
  'Child abuse is a serious problem , and its physical manifestations can be mimicked by certain diseases and conditions .',
  'Child abuse is a serious health problem , which threatens children and has a wide reaching effect on family and society .',
  'The morbidity and mortality that are associated with child abuse is a serious concern for the practicing pediatrician .',
  'However , children separated from their families demonstrated increased emotional vulnerability , and foster placement of children without families presented a serious problem .',
  'Child abuse and neglect is a serious clinical and socioeconomic problem that is sometimes underestimated .',
  'Child maltreatment is a serious problem in US society , affecting approximately three million children .',
  'Child abuse has been recognized as a serious problem , of which the awareness in medical discipline but also in the general public has been increased since many years .',
  'The neglect of children is a serious global problem .',
  'A serious deficiency in any one affects other dimensions and interferes with the ability to experience " a minimally decent life . " The model is applied to the problem of child abuse and the effects of its aftermath on well-being as an example of its potential for structuring nursing knowledge development , practice , and policy initiatives .',
  'Although child abuse has become a serious social problem in most countries , the neural mechanisms by which it induces adulthood mental disorders is not yet fully understood .',
  'Child abuse is a serious problem in many cultures .',
  'Child abuse and neglect ( CNS ) increasingly have become a serious problem in modern society all over the world .',
  'Among marginalized children , that is , children working in the streets but living at home or children living in the street , the problem of inhalant abuse is a serious problem .',
  'Conclusion The phenomenon of street children is a growing problem in the world and it has turned into a serious concern in many countries including Iran .',
  "Child abuse and neglect , or maltreatment , is a serious public health problem , which may cause long-term effects on children 's health and wellbeing and expose them to further adulthood vulnerabilities .",
  'Detecting and responding to child-maltreatment is a serious challenge and public health concern .',
  'Child abuse continues to be a serious problem that is likely to be encountered in all medical specialties , with orthopaedic surgeons commonly evaluating children having sustained musculoskeletal injuries .',
  'Neglect is a frequent type of child maltreatment and a serious problem worldwide , but it has received limited research attention .',
  'Child abuse is still a severe social and psychological problem , and child neglect is more common than child abuse .',
  'Child maltreatment is a severe worldwide public health problem because of its negative consequences and should therefore be prevented through parenting programs to improve parental behavior and practices .',
  'This study provides strong indications that child abuse is a serious public health problem based on the clear links seen between abuse and poor health and behavioral problems .',
  'Because the information children provide during interviews is sometimes the only evidence in forensic situations , its quality is a serious concern .',
  'The author discusses the ways to protect against an infant or child abduction , which is a devastating problem for a healthcare facility .',
  'Child abuse remains a serious and expensive social problem in the United States .',
  'Exposure to traumatic experiences among youth is a serious public health concern .',
  'Childhood trauma due to physical abuse , neglect , or sexual abuse is a serious problem in the United States .',
  'Emotional maltreatment , however , has been slow to achieve recognition as a serious social problem for a variety of reasons .',
  'Childhood abuse is a serious problem that has been linked to harmful alcohol and drug use in non-offender samples .',
  'Child maltreatment is a serious and pervasive problem .',
  'Child maltreatment is a serious public health concern , and its detrimental effects can be compounded by traumatic experiences associated with the child welfare ( CW ) system .',
  'Child maltreatment is a preventable public health problem .',
  "Awareness of child abuse as a serious social problem has risen sharply in recent years , yet there has been only limited and inadequate research on the abused child 's growth and development .",
  'Child abuse is presenting a serious social problem with global dimensions , which is increasing at an alarming rate in all socioeconomic strata and all ethnic or racial communities .',
  'Exposure to adversity and toxic stress in childhood is a serious public health problem .',
  'Child abuse and neglect ( CAN ) is a serious problem that has major implications for the welfare of the child involved .',
  'Child neglect is a serious and prevalent problem .',
  'Child maltreatment ( CM ) is a serious and prevalent public health problem in the United States ( U.S. ) yet programming to combat the issue often overlooks high school aged youth ( those aged 14 - 17 ) .',
  'Child maltreatment is a serious public health problem that disproportionately affects infants and toddlers .',
  'Child abuse is a serious problem in the United States .',
  'Child maltreatment remains a serious but potentially preventable public health concern in the United States .',
  'Child neglect is the most prevalent form of child maltreatment in the United States , and poses a serious public health concern .',
  'Neglect can be a serious and consequential problem for children with chronic illness .',
  'Child maltreatment of all types is a serious concern for society , and it is important to monitor trends in incidence in order to inform child welfare agencies and policy-makers about emerging issues .',
  'Child abuse is a serious problem worldwide and can be difficult to detect .',
  "Child abuse is a serious public health problem and affects the victims ' physical and mental health and development .",
  'Child abuse is a serious problem affecting the pediatric population , which has tremendous medical and social implications .',
  'Child abuse is a serious social health problem all over the world with important adverse effects .',
  'While childhood non-accidental trauma is certainly a serious problem , the wide exposure of this information may have the potential to exonerate some innocent care-givers who have been convicted , or may be accused , of child abuse .',
  'The persistent street children differed greatly from those who entered the orphanage , most markedly in their higher risk of police abuse ( 95 % versus 38 % ) , absence from school ( 84 % versus 19 % ) , engagement in robbery ( 26 % versus 4 % ) , paint thinner use ( 88 % versus 41 % ) , alcohol use ( 58 % versus 12 % ) , and a serious medical problem ( 53 % versus 20 % ) .',
  "Children 's invalidism is a serious social , moral and financial problem in Russia .",
  'Moreover , given that NSSI is a severe health concern that should be prevented , the protective role of parent-child cohesion was also examined .',
  'Childhood maltreatment is a serious public health problem and represents a significant challenge to pediatricians .',
  'Child maltreatment is a serious and prevalent public health problem , which has been shown to be associated with numerous short- and long-term effects on mental and physical health .',
  "Child abuse in rural areas in Ningxia was a serious problem , Children 's cognitive to child abuse was very low .",
  'Childhood abuse is a serious and prevalent public health concern , both in the United States and around the world .'],
 'asphyxia': ['Preterm infants generally spend weeks in the neonatal intensive care unit where light intensity can fluctuate as well as be high, leading to physiological instability and increased motor activity in these infants.',
  'Kernicterus , a preventable injury to the brain from severe neonatal jaundice , has re-emerged in the United States as a public and societal health concern .',
  'Birth asphyxia is a serious clinical problem worldwide .',
  'Hypoxic-ischemic brain injury and hypoxic-ischemic encephalopathy ( HIE ) remain a serious problem for both preterm and term neonates with the spectrum of injury ranging from neuronal injury to encephalopathy and death .',
  'Neonatal brain hypoxic-ischemic injury represents a serious health care and socio-economical problem since it is one of the most common causes of mortality and morbidity of newborns .',
  'Extrauterine growth restriction ( EUGR ) remains a serious problem among very low birth weight ( VLBW ) infants and is a marker of severe nutritional deficit during the first weeks of life .',
  'Postnatal growth restriction remains a serious problem in very low-birth-weight infants .',
  'Periventricular-intraventricular hemorrhage is a serious problem in the premature infant , and is often associated with poor neurological outcome .',
  'Neonatal stroke , including perinatal arterial ischaemic stroke and cerebral sinovenous thrombosis , remains a serious problem in the neonate .',
  'The purpose of this article is to define autoerotic asphyxia and present the enigma as a preventable problem .',
  'Although it has been possible to reduce the percentage of premature infants suffering intraventricular hemorrhage , posthemorrhagic hydrocephalus remains a serious problem without a good treatment .',
  'Birth asphyxia is a serious problem worldwide , resulting in 1 million deaths and an equal number of neurologic sequelae annually .',
  'Although the percentage of preterm infants developing IVH has been greatly reduced in the last three decades , increased survival of these very immature infants has meant that large IVH with subsequent PHH is still a serious unsolved problem .',
  'Low birth weight ( LBW ) infants with reduced nephron numbers have significantly increased risk for hypertension later in life , which is a devastating health problem .',
  'Occurring in five of 1000 live-born infants globally and even more in developing countries , HIE is a serious problem that causes death in 25%-50 % of affected neonates and neurological disability to at least 25 % of survivors .',
  'Bleeding and thrombosis in critically ill infants and children is a vexing clinical problem .',
  'Acute bleeding of different genesis can be a severe , life-threatening problem in neonatology .',
  'Prenatal hypoxia induced by transient intrauterine ischemia is a serious clinical problem , and at present , effective treatments are lacking .',
  'Although in recent years the percentage of preterm infants who suffer intraventricular haemorrhage ( IVH ) has reduced , posthaemorrhagic hydrocephalus ( PHH ) remains a serious problem with a high rate of cerebral palsy and no evidence-based treatment .',
  'Birth asphyxia is a preventable problem and long term neurological sequelae almost untreatable .',
  'Neonatal disorders related to perinatal asphyxia remain a serious clinical problem , which calls for sustained education of advanced neonatal resuscitation and improvement in the quality of perinatal-neonatal care .',
  'Thromboembolic events in preterm infants constitute a serious problem in neonatal intensive care .',
  'Birth asphyxia represents a serious problem worldwide , resulting in approximately 1 million deaths and an equal number of serious sequelae annually .',
  'Bleeding in the newborn is often a serious problem because of cardiovascular effects associated with a loss of blood and/or the damaging effects of bleeding on neonatal tissues , especially the brain .',
  'Thromboembolic disease in newborn infants is a serious problem .',
  'Birth asphyxia represents a serious problem worldwide , resulting in 1 million deaths and an equal number of neurologic sequelae annually .',
  'Despite advances in neonatal care , hypoxic-ischemic brain injury is still a serious clinical problem , which is responsible for many cases of perinatal mortality , cerebral palsy , motor impairment and cognitive deficits .',
  'Hydrocephalus is a serious problem in sub-Saharan Africa , whose effects can be minimized by a better organization of the health system in hydrocephalus prevention , referral , and follow-up .',
  'Amniotic fluid embolism : A catastrophic problem in need of a prepared team with a plan .',
  'Birth asphyxia is a serious clinical problem worldwide .',
  'Although the percentage of small preterm infants developing intraventricular haemorrhage ( IVH ) has been greatly reduced in the last three decades , increased survival of very immature infants has meant that large IVH with subsequent posthaemorrhagic ventricular dilatation is still a serious unsolved problem .',
  'Perinatal asphyxia is a severe problem which causes serious problem in neonates in developing countries .',
  'CNCLUSIONS : This preliminary study concludes that the rate of Pacific SIDS increased in 1995 and remains a serious problem .',
  'Posthaemorrhagic ventricular dilation following intraventricular haemorrhage is a serious problem with high morbidity in preterm babies .',
  'His work has led to the acceptance of caffeine as a standard treatment of apnea in premature infants , and his current studies of ibuprofen as a possible treatment of cerebral intraventricular hemorrhage , a serious problem in some premature babies , have yielded promising results .',
  'Germinal matrix-intraventricular haemorrhage ( GMH-IVH ) remains a serious problem in the very and extremely preterm infant .'],
 'preterm': ['Preterm infants generally spend weeks in the neonatal intensive care unit where light intensity can fluctuate as well as be high, leading to physiological instability and increased motor activity in these infants.',
  'Kernicterus , a preventable injury to the brain from severe neonatal jaundice , has re-emerged in the United States as a public and societal health concern .',
  'Birth asphyxia is a serious clinical problem worldwide .',
  'Hypoxic-ischemic brain injury and hypoxic-ischemic encephalopathy ( HIE ) remain a serious problem for both preterm and term neonates with the spectrum of injury ranging from neuronal injury to encephalopathy and death .',
  'Neonatal brain hypoxic-ischemic injury represents a serious health care and socio-economical problem since it is one of the most common causes of mortality and morbidity of newborns .',
  'Extrauterine growth restriction ( EUGR ) remains a serious problem among very low birth weight ( VLBW ) infants and is a marker of severe nutritional deficit during the first weeks of life .',
  'Postnatal growth restriction remains a serious problem in very low-birth-weight infants .',
  'Periventricular-intraventricular hemorrhage is a serious problem in the premature infant , and is often associated with poor neurological outcome .',
  'Neonatal stroke , including perinatal arterial ischaemic stroke and cerebral sinovenous thrombosis , remains a serious problem in the neonate .',
  'The purpose of this article is to define autoerotic asphyxia and present the enigma as a preventable problem .',
  'Although it has been possible to reduce the percentage of premature infants suffering intraventricular hemorrhage , posthemorrhagic hydrocephalus remains a serious problem without a good treatment .',
  'Birth asphyxia is a serious problem worldwide , resulting in 1 million deaths and an equal number of neurologic sequelae annually .',
  'Although the percentage of preterm infants developing IVH has been greatly reduced in the last three decades , increased survival of these very immature infants has meant that large IVH with subsequent PHH is still a serious unsolved problem .',
  'Low birth weight ( LBW ) infants with reduced nephron numbers have significantly increased risk for hypertension later in life , which is a devastating health problem .',
  'Occurring in five of 1000 live-born infants globally and even more in developing countries , HIE is a serious problem that causes death in 25%-50 % of affected neonates and neurological disability to at least 25 % of survivors .',
  'Bleeding and thrombosis in critically ill infants and children is a vexing clinical problem .',
  'Acute bleeding of different genesis can be a severe , life-threatening problem in neonatology .',
  'Prenatal hypoxia induced by transient intrauterine ischemia is a serious clinical problem , and at present , effective treatments are lacking .',
  'Although in recent years the percentage of preterm infants who suffer intraventricular haemorrhage ( IVH ) has reduced , posthaemorrhagic hydrocephalus ( PHH ) remains a serious problem with a high rate of cerebral palsy and no evidence-based treatment .',
  'Birth asphyxia is a preventable problem and long term neurological sequelae almost untreatable .',
  'Neonatal disorders related to perinatal asphyxia remain a serious clinical problem , which calls for sustained education of advanced neonatal resuscitation and improvement in the quality of perinatal-neonatal care .',
  'Thromboembolic events in preterm infants constitute a serious problem in neonatal intensive care .',
  'Birth asphyxia represents a serious problem worldwide , resulting in approximately 1 million deaths and an equal number of serious sequelae annually .',
  'Bleeding in the newborn is often a serious problem because of cardiovascular effects associated with a loss of blood and/or the damaging effects of bleeding on neonatal tissues , especially the brain .',
  'Thromboembolic disease in newborn infants is a serious problem .',
  'Birth asphyxia represents a serious problem worldwide , resulting in 1 million deaths and an equal number of neurologic sequelae annually .',
  'Despite advances in neonatal care , hypoxic-ischemic brain injury is still a serious clinical problem , which is responsible for many cases of perinatal mortality , cerebral palsy , motor impairment and cognitive deficits .',
  'Hydrocephalus is a serious problem in sub-Saharan Africa , whose effects can be minimized by a better organization of the health system in hydrocephalus prevention , referral , and follow-up .',
  'Amniotic fluid embolism : A catastrophic problem in need of a prepared team with a plan .',
  'Birth asphyxia is a serious clinical problem worldwide .',
  'Although the percentage of small preterm infants developing intraventricular haemorrhage ( IVH ) has been greatly reduced in the last three decades , increased survival of very immature infants has meant that large IVH with subsequent posthaemorrhagic ventricular dilatation is still a serious unsolved problem .',
  'Perinatal asphyxia is a severe problem which causes serious problem in neonates in developing countries .',
  'CNCLUSIONS : This preliminary study concludes that the rate of Pacific SIDS increased in 1995 and remains a serious problem .',
  'Posthaemorrhagic ventricular dilation following intraventricular haemorrhage is a serious problem with high morbidity in preterm babies .',
  'His work has led to the acceptance of caffeine as a standard treatment of apnea in premature infants , and his current studies of ibuprofen as a possible treatment of cerebral intraventricular hemorrhage , a serious problem in some premature babies , have yielded promising results .',
  'Germinal matrix-intraventricular haemorrhage ( GMH-IVH ) remains a serious problem in the very and extremely preterm infant .'],
 'hernia': ['Laparoscopic incisional and ventral hernia repair (LIVHR) has been associated with a high incidence acute and chronic pain due to use of nonabsorbable tackers.',
  'Chronic postoperative pain is a major drawback of inguinal hernia repair .',
  'The need for stapling is a relative drawback of laparoscopic hernia repairs because it adds to the complications and costs .',
  'Prolonged operative time ( ORT ) is a drawback of laparoscopic bariatric surgery due to concerns for increased morbidity .',
  'The reported incidence of chronic pain in patients who underwent laparoscopic hernia repair is a serious problem .',
  'Large upper abdominal incisional hernias have always been a vexing problem to surgeons because of the rigidity of the costal arches .',
  'The surgical repair of giant hernias is a serious problem .',
  'Parastomal hernia , particularly when recurrent , presents a troublesome problem to the surgeon .',
  'Reconstruction of massive abdominal wall defects has long been a vexing clinical problem .',
  'Major incisional hernias of the abdominal wall often pose a serious surgical problem .',
  'Internal hernias ( IH ) after Roux-en-Y gastric bypass ( RYGB ) are a serious concern among surgeons and are often under-diagnosed due to heterogeneity of clinical manifestations .',
  "Recurrence after laparoscopic ventral hernioplasty is a severe problem despite surgeons ' increased experience in recent years .",
  'Ventral/incisional abdominal hernias following celiotomies continue to be a vexing problem for both patients and general and plastic and reconstructive surgeons , since no universally applicable preventive or reconstructive techniques have evolved .',
  'Para-oesophageal hernia may be a serious problem with major complications .',
  'A common surgical procedure , ventral hernia repair has long been a vexing problem , with no clear standard for repair and significant postoperative morbidity .',
  'Incarcerated inguinal hernia in elderly patients is a serious problem .',
  'Postoperative hernia following bariatric procedures is more common than in other groups of surgical patients , and remains a serious problem .',
  'Considering its frequency , postoperative ventral hernia is a serious health problem .',
  'Chronic groin pain after inguinal hernia repair , a serious problem , is caused by entrapment of the ilioinguinal nerve either by mesh or development of fibrosis .',
  'Treatment of incarcerated abdominal hernia is a serious surgical problem .',
  'The morbidity/mortality associated with ventral hernias continues to be a serious medical problem due to high rates of recurrence .',
  'Chronic groin pain after inguinal hernia repair ( IHR ) is a vexing problem .',
  'Incisional hernias still continue to be a serious problem for surgeons .'],
 'hernias': ['Laparoscopic incisional and ventral hernia repair (LIVHR) has been associated with a high incidence acute and chronic pain due to use of nonabsorbable tackers.',
  'Chronic postoperative pain is a major drawback of inguinal hernia repair .',
  'The need for stapling is a relative drawback of laparoscopic hernia repairs because it adds to the complications and costs .',
  'Prolonged operative time ( ORT ) is a drawback of laparoscopic bariatric surgery due to concerns for increased morbidity .',
  'The reported incidence of chronic pain in patients who underwent laparoscopic hernia repair is a serious problem .',
  'Large upper abdominal incisional hernias have always been a vexing problem to surgeons because of the rigidity of the costal arches .',
  'The surgical repair of giant hernias is a serious problem .',
  'Parastomal hernia , particularly when recurrent , presents a troublesome problem to the surgeon .',
  'Reconstruction of massive abdominal wall defects has long been a vexing clinical problem .',
  'Major incisional hernias of the abdominal wall often pose a serious surgical problem .',
  'Internal hernias ( IH ) after Roux-en-Y gastric bypass ( RYGB ) are a serious concern among surgeons and are often under-diagnosed due to heterogeneity of clinical manifestations .',
  "Recurrence after laparoscopic ventral hernioplasty is a severe problem despite surgeons ' increased experience in recent years .",
  'Ventral/incisional abdominal hernias following celiotomies continue to be a vexing problem for both patients and general and plastic and reconstructive surgeons , since no universally applicable preventive or reconstructive techniques have evolved .',
  'Para-oesophageal hernia may be a serious problem with major complications .',
  'A common surgical procedure , ventral hernia repair has long been a vexing problem , with no clear standard for repair and significant postoperative morbidity .',
  'Incarcerated inguinal hernia in elderly patients is a serious problem .',
  'Postoperative hernia following bariatric procedures is more common than in other groups of surgical patients , and remains a serious problem .',
  'Considering its frequency , postoperative ventral hernia is a serious health problem .',
  'Chronic groin pain after inguinal hernia repair , a serious problem , is caused by entrapment of the ilioinguinal nerve either by mesh or development of fibrosis .',
  'Treatment of incarcerated abdominal hernia is a serious surgical problem .',
  'The morbidity/mortality associated with ventral hernias continues to be a serious medical problem due to high rates of recurrence .',
  'Chronic groin pain after inguinal hernia repair ( IHR ) is a vexing problem .',
  'Incisional hernias still continue to be a serious problem for surgeons .'],
 'incisional': ['Laparoscopic incisional and ventral hernia repair (LIVHR) has been associated with a high incidence acute and chronic pain due to use of nonabsorbable tackers.',
  'Chronic postoperative pain is a major drawback of inguinal hernia repair .',
  'The need for stapling is a relative drawback of laparoscopic hernia repairs because it adds to the complications and costs .',
  'Prolonged operative time ( ORT ) is a drawback of laparoscopic bariatric surgery due to concerns for increased morbidity .',
  'The reported incidence of chronic pain in patients who underwent laparoscopic hernia repair is a serious problem .',
  'Large upper abdominal incisional hernias have always been a vexing problem to surgeons because of the rigidity of the costal arches .',
  'The surgical repair of giant hernias is a serious problem .',
  'Parastomal hernia , particularly when recurrent , presents a troublesome problem to the surgeon .',
  'Reconstruction of massive abdominal wall defects has long been a vexing clinical problem .',
  'Major incisional hernias of the abdominal wall often pose a serious surgical problem .',
  'Internal hernias ( IH ) after Roux-en-Y gastric bypass ( RYGB ) are a serious concern among surgeons and are often under-diagnosed due to heterogeneity of clinical manifestations .',
  "Recurrence after laparoscopic ventral hernioplasty is a severe problem despite surgeons ' increased experience in recent years .",
  'Ventral/incisional abdominal hernias following celiotomies continue to be a vexing problem for both patients and general and plastic and reconstructive surgeons , since no universally applicable preventive or reconstructive techniques have evolved .',
  'Para-oesophageal hernia may be a serious problem with major complications .',
  'A common surgical procedure , ventral hernia repair has long been a vexing problem , with no clear standard for repair and significant postoperative morbidity .',
  'Incarcerated inguinal hernia in elderly patients is a serious problem .',
  'Postoperative hernia following bariatric procedures is more common than in other groups of surgical patients , and remains a serious problem .',
  'Considering its frequency , postoperative ventral hernia is a serious health problem .',
  'Chronic groin pain after inguinal hernia repair , a serious problem , is caused by entrapment of the ilioinguinal nerve either by mesh or development of fibrosis .',
  'Treatment of incarcerated abdominal hernia is a serious surgical problem .',
  'The morbidity/mortality associated with ventral hernias continues to be a serious medical problem due to high rates of recurrence .',
  'Chronic groin pain after inguinal hernia repair ( IHR ) is a vexing problem .',
  'Incisional hernias still continue to be a serious problem for surgeons .'],
 'abdominal': ['Laparoscopic incisional and ventral hernia repair (LIVHR) has been associated with a high incidence acute and chronic pain due to use of nonabsorbable tackers.',
  'Chronic postoperative pain is a major drawback of inguinal hernia repair .',
  'The need for stapling is a relative drawback of laparoscopic hernia repairs because it adds to the complications and costs .',
  'Prolonged operative time ( ORT ) is a drawback of laparoscopic bariatric surgery due to concerns for increased morbidity .',
  'The reported incidence of chronic pain in patients who underwent laparoscopic hernia repair is a serious problem .',
  'Large upper abdominal incisional hernias have always been a vexing problem to surgeons because of the rigidity of the costal arches .',
  'The surgical repair of giant hernias is a serious problem .',
  'Parastomal hernia , particularly when recurrent , presents a troublesome problem to the surgeon .',
  'Reconstruction of massive abdominal wall defects has long been a vexing clinical problem .',
  'Major incisional hernias of the abdominal wall often pose a serious surgical problem .',
  'Internal hernias ( IH ) after Roux-en-Y gastric bypass ( RYGB ) are a serious concern among surgeons and are often under-diagnosed due to heterogeneity of clinical manifestations .',
  "Recurrence after laparoscopic ventral hernioplasty is a severe problem despite surgeons ' increased experience in recent years .",
  'Ventral/incisional abdominal hernias following celiotomies continue to be a vexing problem for both patients and general and plastic and reconstructive surgeons , since no universally applicable preventive or reconstructive techniques have evolved .',
  'Para-oesophageal hernia may be a serious problem with major complications .',
  'A common surgical procedure , ventral hernia repair has long been a vexing problem , with no clear standard for repair and significant postoperative morbidity .',
  'Incarcerated inguinal hernia in elderly patients is a serious problem .',
  'Postoperative hernia following bariatric procedures is more common than in other groups of surgical patients , and remains a serious problem .',
  'Considering its frequency , postoperative ventral hernia is a serious health problem .',
  'Chronic groin pain after inguinal hernia repair , a serious problem , is caused by entrapment of the ilioinguinal nerve either by mesh or development of fibrosis .',
  'Treatment of incarcerated abdominal hernia is a serious surgical problem .',
  'The morbidity/mortality associated with ventral hernias continues to be a serious medical problem due to high rates of recurrence .',
  'Chronic groin pain after inguinal hernia repair ( IHR ) is a vexing problem .',
  'Incisional hernias still continue to be a serious problem for surgeons .'],
 'adherence': ['Low levels of adherence to medication prescribed to treat and manage chronic disease may lead to maladaptive health outcomes.',
  'Medication non-adherence is a major contributor to poor outcomes in diabetes',
  "Medication nonadherence is a vexing problem in health care necessitating patients and health professionals ' efforts to prevent , minimize , or reverse it .",
  'Prescription medication nonadherence among the elderly is a serious medical problem .',
  'Poor adherence with prescription medications is a serious problem in health care , especially true for patients with chronic diseases .',
  'Suboptimal medication adherence is a serious problem in the treatment of chronic inflammatory diseases .',
  'Nonadherence to HIV medications is a serious unsolved problem and is a major cause of morbidity and mortality in the HIV-positive population .',
  'Compliance with taking the vitamin K1 , which required ingestion of 60 - 160 tablets/day , was a serious problem , requiring numerous follow-up calls and visits to the patient at home and work .',
  'Poor medication adherence is a serious medical problem , particularly in older adults .',
  'Non-adherence in seniors with dementia - a serious problem of routine clinical practice .',
  'Non-adherence to prescribed medications is a serious health problem in the United States , costing an estimated $ 100 billion per year .',
  'Poor therapeutic adherence in homebound elderly patients receiving polypharmacy is a serious problem affecting one of every three individuals concerned , and is directly related to caregiver burden , regardless of age , sex , cognitive status or number of drugs administered .',
  'Nonadherence in children who use long-term medication is a serious problem and assessing adherence is an important step to provide solutions to this problem .',
  'Insufficient adherence of patients to treatment is a serious problem and it is monitored most frequently in hypertensive patients .',
  'Medication non-adherence is a serious problem for medical research and clinical practice .',
  'Non-adherence to cardiovascular medications is a serious problem in the aging Australian setting with an overall prevalence of between 14 and 43 \xa0 % .',
  'Depending on definitions , reported non-adherence rates in cancer patients ranges between 16 and 100 % , which illustrates a serious problem .',
  "Based on assessment of the patient 's inventory , 40 % of the patients studied were noncompliant with their prescribed exchanges , indicating this is a serious and common problem in PD patients .",
  'Polypharmacy is often prescribed for bipolar disorder , yet medication non-adherence remains a serious problem .',
  'Medication nonadherence is a serious public health concern .',
  'Despite the importance of adherence , medication nonadherence is a serious problem , with the World Health Organization noting that the average nonadherence rate is 50 % among those with chronic illnesses .',
  'Prescription noncompliance due to cost is a serious problem for many adults with chronic disease or disability . Most would not be helped by any of the current proposals to expand Medicare drug coverage .',
  'Patient adherence to medication or lifestyle interventions is a serious concern .'],
 'prescribed': ['Low levels of adherence to medication prescribed to treat and manage chronic disease may lead to maladaptive health outcomes.',
  'Medication non-adherence is a major contributor to poor outcomes in diabetes',
  "Medication nonadherence is a vexing problem in health care necessitating patients and health professionals ' efforts to prevent , minimize , or reverse it .",
  'Prescription medication nonadherence among the elderly is a serious medical problem .',
  'Poor adherence with prescription medications is a serious problem in health care , especially true for patients with chronic diseases .',
  'Suboptimal medication adherence is a serious problem in the treatment of chronic inflammatory diseases .',
  'Nonadherence to HIV medications is a serious unsolved problem and is a major cause of morbidity and mortality in the HIV-positive population .',
  'Compliance with taking the vitamin K1 , which required ingestion of 60 - 160 tablets/day , was a serious problem , requiring numerous follow-up calls and visits to the patient at home and work .',
  'Poor medication adherence is a serious medical problem , particularly in older adults .',
  'Non-adherence in seniors with dementia - a serious problem of routine clinical practice .',
  'Non-adherence to prescribed medications is a serious health problem in the United States , costing an estimated $ 100 billion per year .',
  'Poor therapeutic adherence in homebound elderly patients receiving polypharmacy is a serious problem affecting one of every three individuals concerned , and is directly related to caregiver burden , regardless of age , sex , cognitive status or number of drugs administered .',
  'Nonadherence in children who use long-term medication is a serious problem and assessing adherence is an important step to provide solutions to this problem .',
  'Insufficient adherence of patients to treatment is a serious problem and it is monitored most frequently in hypertensive patients .',
  'Medication non-adherence is a serious problem for medical research and clinical practice .',
  'Non-adherence to cardiovascular medications is a serious problem in the aging Australian setting with an overall prevalence of between 14 and 43 \xa0 % .',
  'Depending on definitions , reported non-adherence rates in cancer patients ranges between 16 and 100 % , which illustrates a serious problem .',
  "Based on assessment of the patient 's inventory , 40 % of the patients studied were noncompliant with their prescribed exchanges , indicating this is a serious and common problem in PD patients .",
  'Polypharmacy is often prescribed for bipolar disorder , yet medication non-adherence remains a serious problem .',
  'Medication nonadherence is a serious public health concern .',
  'Despite the importance of adherence , medication nonadherence is a serious problem , with the World Health Organization noting that the average nonadherence rate is 50 % among those with chronic illnesses .',
  'Prescription noncompliance due to cost is a serious problem for many adults with chronic disease or disability . Most would not be helped by any of the current proposals to expand Medicare drug coverage .',
  'Patient adherence to medication or lifestyle interventions is a serious concern .'],
 'lumbar': ['Lumbar spinal stenosis is a common diagnosis in elderly individuals, and the rates of surgery have risen all over the world.',
  'Lumbar disc degeneration ( LDD ) is a serious social and medical problem which has been shown to be highly heritable .',
  'Successful treatment of lumbar disc herniation constitutes a serious interdisciplinary problem .',
  'Low back pain after either post lumbar surgery syndrome or spinal stenosis in the absence of surgery is a vexing problem .',
  'Intervertebral disc degeneration ( IDD ) is thought to be the primary cause of low back pain , a severe public health problem worldwide .',
  'Degenerative disc disease in the lumbar spine is a serious health problem .',
  'Scoliosis is a serious clinical problem which requires a systematic physical therapy and control of body balance - treatment from the moment of achieving skeletal maturity by a child .',
  'Spinal disease due to intervertebral disc degeneration represents a serious medical problem which affects many people worldwide .',
  'Spine pain is a serious clinical problem of physically active people and sportplayers .',
  'Classic degenerative disc disease is a serious health problem worldwide , whose etiological basis-mechanical stimulus , biochemical changes , or natural aging-is poorly understood .',
  'As KBD may be linked with chronic pain and a decrease in mobility , it is a serious welfare problem .',
  'Intervertebral disc degeneration ( IDD ) is a serious health problem worldwide .',
  'Degenerative spine disease is a serious social problem .'],
 'degenerative': ['Lumbar spinal stenosis is a common diagnosis in elderly individuals, and the rates of surgery have risen all over the world.',
  'Lumbar disc degeneration ( LDD ) is a serious social and medical problem which has been shown to be highly heritable .',
  'Successful treatment of lumbar disc herniation constitutes a serious interdisciplinary problem .',
  'Low back pain after either post lumbar surgery syndrome or spinal stenosis in the absence of surgery is a vexing problem .',
  'Intervertebral disc degeneration ( IDD ) is thought to be the primary cause of low back pain , a severe public health problem worldwide .',
  'Degenerative disc disease in the lumbar spine is a serious health problem .',
  'Scoliosis is a serious clinical problem which requires a systematic physical therapy and control of body balance - treatment from the moment of achieving skeletal maturity by a child .',
  'Spinal disease due to intervertebral disc degeneration represents a serious medical problem which affects many people worldwide .',
  'Spine pain is a serious clinical problem of physically active people and sportplayers .',
  'Classic degenerative disc disease is a serious health problem worldwide , whose etiological basis-mechanical stimulus , biochemical changes , or natural aging-is poorly understood .',
  'As KBD may be linked with chronic pain and a decrease in mobility , it is a serious welfare problem .',
  'Intervertebral disc degeneration ( IDD ) is a serious health problem worldwide .',
  'Degenerative spine disease is a serious social problem .'],
 'spine': ['Lumbar spinal stenosis is a common diagnosis in elderly individuals, and the rates of surgery have risen all over the world.',
  'Lumbar disc degeneration ( LDD ) is a serious social and medical problem which has been shown to be highly heritable .',
  'Successful treatment of lumbar disc herniation constitutes a serious interdisciplinary problem .',
  'Low back pain after either post lumbar surgery syndrome or spinal stenosis in the absence of surgery is a vexing problem .',
  'Intervertebral disc degeneration ( IDD ) is thought to be the primary cause of low back pain , a severe public health problem worldwide .',
  'Degenerative disc disease in the lumbar spine is a serious health problem .',
  'Scoliosis is a serious clinical problem which requires a systematic physical therapy and control of body balance - treatment from the moment of achieving skeletal maturity by a child .',
  'Spinal disease due to intervertebral disc degeneration represents a serious medical problem which affects many people worldwide .',
  'Spine pain is a serious clinical problem of physically active people and sportplayers .',
  'Classic degenerative disc disease is a serious health problem worldwide , whose etiological basis-mechanical stimulus , biochemical changes , or natural aging-is poorly understood .',
  'As KBD may be linked with chronic pain and a decrease in mobility , it is a serious welfare problem .',
  'Intervertebral disc degeneration ( IDD ) is a serious health problem worldwide .',
  'Degenerative spine disease is a serious social problem .'],
 'pneumonia': ['In non-pregnant adults, the incidence of invasive Group B Streptococcus (GBS) disease is continuously increasing.',
  'Pneumococcal conjugate vaccines have reduced the incidence of invasive pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a concern',
  'Antimicrobial resistance of Streptococcus pneumoniae, especially against β-lactam antibiotics, is a global concern',
  'An inherent problem with the new pneumococcal conjugate vaccines is that , while more than 20 pneumococcal serotypes may cause invasive disease , only a more limited number of polysaccharides , 11 or so , can in practice be conjugated to carrier protein as part of a single vaccine formulation .',
  'The investigations detailed in the present paper have dealt chiefly with the first problem and incidentally with the second , and lead to the following conclusions : ( a ) That organisms , not to be distinguished by morphological characters or by any physiological peculiarities from true pneumococci derived from pathologic sources , occur with frequency in the mouths of healthy persons and those suffering from slight inflammations of the naso pharynx , and that the only permissible and legitimate conclusion is that these organisms are true pneumococci .',
  'Infections caused by Streptococcus pneumoniae ( pneumococcus ) are still meaning a serious health problem , about 40 % of community acquired pneumonia ( CAP ) is due to pneumococcal bacteria in adults requiring hospitalization .',
  'Invasive pneumococcal diseases ( IPD ) have become a severe problem of public health worldwide .',
  'Ventilator-associated pneumonia ( VAP ) is a serious and costly clinical problem affecting pediatrics today .',
  'Thus , outbreaks of pneumocystosis are a serious problem among colonies of immunodeficient mice , with important implications for the use of these animals in biomedical research .',
  'Increasing pneumococcal resistance to commonly used antibiotics and multidrug resistance is a serious public health concern .',
  'Pneumonia is a serious global health problem and the leading cause of mortality in children .',
  'Ventilator-associated pneumonia ( VAP ) occurs in a patient treated with mechanical ventilation , and it is neither present nor developing at the time of intubation ; it is a serious problem -- with significant morbidity and mortality rates .',
  'Community-acquired pneumonia in adults is a serious health problem in the ambulatory care setting .',
  'A serious therapeutic problem is posed by the infections caused by streptococci mainly due to their ability to recur .',
  'The diagnosis and the treatment of community-acquired severe pneumonia is still a serious child health problem in developing countries .',
  'Since this time the increasing emergence of penicillin- resistant strains of Streptococcus pneumoniae have been a serious therapeutic problem .',
  'Invasive pneumococcal infections among children are a serious public health problem in many countries , including Turkey .',
  'Ventilator-associated pneumonia ( VAP ) is a serious and costly clinical problem .',
  'Streptococcus pneumoniae infection is a serious problem worldwide and the case fatality rate remains high .',
  'Pneumococcal infections continue to pose a serious medical problem .',
  'Streptococcal toxic shock syndrome is a serious health problem in developed and developing countries .',
  'C. pneumoniae infection is associated with respiratory tract infection and chronic respiratory disease , which is a serious public health concern .',
  'The multiresistance of S. pneumoniae poses a serious therapeutic problem and should make myringotomy and bacteriological sampling obligatory in cases of antibiotic treatment failure .',
  'Pneumococcal disease is a serious global public health problem and a leading cause of morbidity and mortality of children and adults in China .',
  'However , ventilator-associated pneumonia still remains a serious controversy-generating problem in intensive care unit .',
  'Macrolide resistance of the B. pertussis population has been a serious problem in the northern part of China .',
  'Unfortunately , protection is raised against a limited number of pneumococcal serotypes , and serotype replacement and subsequent vaccine failure have become a serious concern .',
  'Invasive pneumococcal disease ( IPD ) is a serious problem in some risk groups : patients with stage 4 and 5 chronic kidney disease , stage 3 CKD undergoing immunosuppressive treatment , nephrotic syndrome or diabetes .',
  'Although pneumococcal infection is a serious problem worldwide and has a high mortality rate , the molecular mechanisms underlying the lethality caused by pneumococcus remain elusive .',
  'In Morocco , pediatric pneumonia remains a serious public health problem , as it constitutes the first cause of mortality due to infectious diseases .',
  'Acute pneumonia is a serious problem in the elderly and various risk factors have already been reported , but the involvement of QTc interval prolongation remains uncertain .',
  'Pneumococcal meningitis , which represents the third in frequency among the purulent forms of meningitis , continues to be , in spite of antibiotic therapy , a serious problem due to its high mortality rate , which reaches 50 per cent in patients of advanced age .',
  'Antimicrobial resistant S. pneumoniae has already become a serious problem in China .',
  'Accelerating prevalence of coal workers pneumoconiosis is considered as a serious occupational health problem .',
  'Penicillin prophylaxis against infection by Streptococcus pneumoniae is now routine in young children with homozygous sickle-cell ( SS ) disease and the emergence of penicillin-resistant strains is a serious clinical concern .',
  'Repeated aspiration pneumonia is a serious problem in the elderly .',
  'Community-acquired pneumonia ( CAP ) is a serious health problem in Chile .',
  'IAV pneumonia remains a serious global health problem , and preventative and therapeutic strategies remain limited .',
  '[ Penicillin resistant pneumococcus . A serious problem of public health ] .',
  'The increasing emergence of penicillin-resistant and multidrug-resistant strains of Streptococcus pneumoniae will create a serious therapeutic problem in coming years .',
  'Recurrent group A beta-hemolytic streptococcus ( GABHS ) pharyngotonsillitis related to penicillin failure presents a serious clinical problem .',
  'The contamination of C. pneumoniae stock cultures , frequently used in the microimmunofluorescence test , with human pathogens , could pose a serious problem in C. pneumoniae serology .',
  'Along with other multidrug-resistant pathogens previously identified , Streptococcus pneumoniae is becoming a serious concern in hospital and ambulatory care settings .',
  'Streptococcus pneumoniae strains with decreased susceptibility to penicillin have become increasingly prevalent over the past 30 years and are now a serious problem worldwide .',
  'Despite the decreased number of cases among HIV-infected patients over the past decade , Pneumocystis pneumonia continues to be a serious problem in immunodeficient patients with other immunosuppressive conditions .',
  'Aspiration pneumonia is a serious health concern in older patients with schizophrenia .',
  'Community-acquired pneumonia ( CAP ) is a serious clinical problem , causing hospitalization in about 20 % of cases and death in up to 16 % of hospitalized patients .',
  'Pneumococcal infections result in substantial morbidity and mortality among children under 5 years of age ; it is estimated that 1,600,000 deaths occur per year in that age range alone , mostly in developing countries , thus representing a serious public health problem around the globe .',
  'Globally , pneumonia is a serious public health concern and a major cause of mortality and morbidity .',
  'Because Streptococcus pneumoniae is a major pathogen that causes community-acquired lower respiratory tract infections and meningitis in adults and children , antibiotic-resistance in this organism is a serious problem .',
  'Aspiration pneumonia is a serious problem for the elderly institutionalized person , often requiring transfer to a hospital and a lengthy stay there .',
  'Pneumonia continues to be a severe health problem in the United States , responsible for close to 1 million hospital admissions and nearly 140,000 hospital readmissions per year .',
  'Multidrug resistance became a serious concern in the treatment of invasive pneumococcal diseases , especially in Asian countries .',
  'Ventilator-associated pneumonia ( VAP ) is a serious concern for patients in the Neuroscience Intensive Care Unit ( NSICU ) .',
  'An abrupt antimicrobial resistance increase among Streptococcus pneumoniae strains has become a serious therapeutic problem in the recent years .',
  'Our findings indicated that IPDs caused by mucoid-type S. \xa0 pneumoniae are still a serious concern and mucoid-type S. \xa0 pneumoniae with novel phenotype could emerge via capsular switching in response to environmental changes such as introduction of vaccines and improper use of antimicrobial agents .',
  'Community-acquired pneumonia ( CAP ) is a serious social and medical problem in the elderly .',
  'Penicillin resistant pneumococcal infection -- a serious concern for India .',
  'Pneumococcal infection being one of the dominant causes of acute respiratory diseases and exacerbation of chronic ones is a serious problem for human health and society .',
  'The increasing incidence of macrolide- and tetracycline-resistant pneumococci among children has been a serious problem in China for many years .',
  'Penicillin-resistant Streptococcus pneumoniae is a serious concern worldwide .',
  'Whether patients who had AF would be susceptible to the development of hospital-acquired pneumonia ( HAP ) is a serious concern but this has not been investigated .',
  'Data confirm that macrolide resistance in pneumococci is a serious problem in many Asian countries .',
  'Antimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide , particularly in Asian countries , despite the introduction of heptavalent pneumococcal conjugate vaccine ( PCV7 ) .',
  'In spite of the availability of potent antibiotics and sophisticated diagnostic techniques , pneumonia continues to be a serious problem among elders .',
  'Pneumonia is a serious problem worldwide .',
  'S. pneumoniae infection remains a serious public health concern despite the availability of vaccines covering up to 23 of more than 94 known serotypes .',
  'Aspiration pneumonia is a serious problem among elderly patients ; it is caused by many risk factors including dysphagia , poor oral hygiene , malnutrition , and sedative medications .',
  'Streptococcal A infections are reemerging as a dangerous clinical problem .',
  'Despite modern antibiotic therapies , pneumococcal pneumonia still remains a serious epidemiologic problem .',
  'The recent emergence of strains of drug-resistant Streptococcus pneumoniae ( DRSP ) is a serious clinical and public health problem .',
  'Streptococcus pneumoniae is a serious public health problem , especially in developing countries , where available vaccines are not part of the vaccination calendar .',
  'The antibiotic resistance of pneumococcus is not currently a severe problem .',
  'In addition , pneumonia in the elderly is a life-threatening problem .',
  'VAP is a serious problem in ICU carrying many risks for the patient live .',
  'Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine , but the immunophysiological processes that confer either protection or morbidity are not completely understood .',
  'Macrolide resistance in Bordetella pertussis is a serious problem in Zhejiang Province , China .',
  'Emergent resistance to antibiotics among Streptococcus pneumoniae isolates is a severe problem worldwide .',
  'Bacterial infections caused by Group A Streptococcus ( GAS ) are a serious health care concern that currently can not be prevented by vaccination .',
  'Pneumococcal disease is a serious global public health problem and a leading cause of morbidity and mortality of children and adults in China .',
  'Pneumocystis pneumonia complicating immunosuppressive therapy in Crohns disease : A preventable problem ?',
  'Environmental streptococci are a severe problem .',
  'PSGN continues to be a serious public health concern in third world countries , but the incidence of streptococcal infections has steadily declined in industrialized nations .'],
 'pneumococcal': ['In non-pregnant adults, the incidence of invasive Group B Streptococcus (GBS) disease is continuously increasing.',
  'Pneumococcal conjugate vaccines have reduced the incidence of invasive pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a concern',
  'Antimicrobial resistance of Streptococcus pneumoniae, especially against β-lactam antibiotics, is a global concern',
  'An inherent problem with the new pneumococcal conjugate vaccines is that , while more than 20 pneumococcal serotypes may cause invasive disease , only a more limited number of polysaccharides , 11 or so , can in practice be conjugated to carrier protein as part of a single vaccine formulation .',
  'The investigations detailed in the present paper have dealt chiefly with the first problem and incidentally with the second , and lead to the following conclusions : ( a ) That organisms , not to be distinguished by morphological characters or by any physiological peculiarities from true pneumococci derived from pathologic sources , occur with frequency in the mouths of healthy persons and those suffering from slight inflammations of the naso pharynx , and that the only permissible and legitimate conclusion is that these organisms are true pneumococci .',
  'Infections caused by Streptococcus pneumoniae ( pneumococcus ) are still meaning a serious health problem , about 40 % of community acquired pneumonia ( CAP ) is due to pneumococcal bacteria in adults requiring hospitalization .',
  'Invasive pneumococcal diseases ( IPD ) have become a severe problem of public health worldwide .',
  'Ventilator-associated pneumonia ( VAP ) is a serious and costly clinical problem affecting pediatrics today .',
  'Thus , outbreaks of pneumocystosis are a serious problem among colonies of immunodeficient mice , with important implications for the use of these animals in biomedical research .',
  'Increasing pneumococcal resistance to commonly used antibiotics and multidrug resistance is a serious public health concern .',
  'Pneumonia is a serious global health problem and the leading cause of mortality in children .',
  'Ventilator-associated pneumonia ( VAP ) occurs in a patient treated with mechanical ventilation , and it is neither present nor developing at the time of intubation ; it is a serious problem -- with significant morbidity and mortality rates .',
  'Community-acquired pneumonia in adults is a serious health problem in the ambulatory care setting .',
  'A serious therapeutic problem is posed by the infections caused by streptococci mainly due to their ability to recur .',
  'The diagnosis and the treatment of community-acquired severe pneumonia is still a serious child health problem in developing countries .',
  'Since this time the increasing emergence of penicillin- resistant strains of Streptococcus pneumoniae have been a serious therapeutic problem .',
  'Invasive pneumococcal infections among children are a serious public health problem in many countries , including Turkey .',
  'Ventilator-associated pneumonia ( VAP ) is a serious and costly clinical problem .',
  'Streptococcus pneumoniae infection is a serious problem worldwide and the case fatality rate remains high .',
  'Pneumococcal infections continue to pose a serious medical problem .',
  'Streptococcal toxic shock syndrome is a serious health problem in developed and developing countries .',
  'C. pneumoniae infection is associated with respiratory tract infection and chronic respiratory disease , which is a serious public health concern .',
  'The multiresistance of S. pneumoniae poses a serious therapeutic problem and should make myringotomy and bacteriological sampling obligatory in cases of antibiotic treatment failure .',
  'Pneumococcal disease is a serious global public health problem and a leading cause of morbidity and mortality of children and adults in China .',
  'However , ventilator-associated pneumonia still remains a serious controversy-generating problem in intensive care unit .',
  'Macrolide resistance of the B. pertussis population has been a serious problem in the northern part of China .',
  'Unfortunately , protection is raised against a limited number of pneumococcal serotypes , and serotype replacement and subsequent vaccine failure have become a serious concern .',
  'Invasive pneumococcal disease ( IPD ) is a serious problem in some risk groups : patients with stage 4 and 5 chronic kidney disease , stage 3 CKD undergoing immunosuppressive treatment , nephrotic syndrome or diabetes .',
  'Although pneumococcal infection is a serious problem worldwide and has a high mortality rate , the molecular mechanisms underlying the lethality caused by pneumococcus remain elusive .',
  'In Morocco , pediatric pneumonia remains a serious public health problem , as it constitutes the first cause of mortality due to infectious diseases .',
  'Acute pneumonia is a serious problem in the elderly and various risk factors have already been reported , but the involvement of QTc interval prolongation remains uncertain .',
  'Pneumococcal meningitis , which represents the third in frequency among the purulent forms of meningitis , continues to be , in spite of antibiotic therapy , a serious problem due to its high mortality rate , which reaches 50 per cent in patients of advanced age .',
  'Antimicrobial resistant S. pneumoniae has already become a serious problem in China .',
  'Accelerating prevalence of coal workers pneumoconiosis is considered as a serious occupational health problem .',
  'Penicillin prophylaxis against infection by Streptococcus pneumoniae is now routine in young children with homozygous sickle-cell ( SS ) disease and the emergence of penicillin-resistant strains is a serious clinical concern .',
  'Repeated aspiration pneumonia is a serious problem in the elderly .',
  'Community-acquired pneumonia ( CAP ) is a serious health problem in Chile .',
  'IAV pneumonia remains a serious global health problem , and preventative and therapeutic strategies remain limited .',
  '[ Penicillin resistant pneumococcus . A serious problem of public health ] .',
  'The increasing emergence of penicillin-resistant and multidrug-resistant strains of Streptococcus pneumoniae will create a serious therapeutic problem in coming years .',
  'Recurrent group A beta-hemolytic streptococcus ( GABHS ) pharyngotonsillitis related to penicillin failure presents a serious clinical problem .',
  'The contamination of C. pneumoniae stock cultures , frequently used in the microimmunofluorescence test , with human pathogens , could pose a serious problem in C. pneumoniae serology .',
  'Along with other multidrug-resistant pathogens previously identified , Streptococcus pneumoniae is becoming a serious concern in hospital and ambulatory care settings .',
  'Streptococcus pneumoniae strains with decreased susceptibility to penicillin have become increasingly prevalent over the past 30 years and are now a serious problem worldwide .',
  'Despite the decreased number of cases among HIV-infected patients over the past decade , Pneumocystis pneumonia continues to be a serious problem in immunodeficient patients with other immunosuppressive conditions .',
  'Aspiration pneumonia is a serious health concern in older patients with schizophrenia .',
  'Community-acquired pneumonia ( CAP ) is a serious clinical problem , causing hospitalization in about 20 % of cases and death in up to 16 % of hospitalized patients .',
  'Pneumococcal infections result in substantial morbidity and mortality among children under 5 years of age ; it is estimated that 1,600,000 deaths occur per year in that age range alone , mostly in developing countries , thus representing a serious public health problem around the globe .',
  'Globally , pneumonia is a serious public health concern and a major cause of mortality and morbidity .',
  'Because Streptococcus pneumoniae is a major pathogen that causes community-acquired lower respiratory tract infections and meningitis in adults and children , antibiotic-resistance in this organism is a serious problem .',
  'Aspiration pneumonia is a serious problem for the elderly institutionalized person , often requiring transfer to a hospital and a lengthy stay there .',
  'Pneumonia continues to be a severe health problem in the United States , responsible for close to 1 million hospital admissions and nearly 140,000 hospital readmissions per year .',
  'Multidrug resistance became a serious concern in the treatment of invasive pneumococcal diseases , especially in Asian countries .',
  'Ventilator-associated pneumonia ( VAP ) is a serious concern for patients in the Neuroscience Intensive Care Unit ( NSICU ) .',
  'An abrupt antimicrobial resistance increase among Streptococcus pneumoniae strains has become a serious therapeutic problem in the recent years .',
  'Our findings indicated that IPDs caused by mucoid-type S. \xa0 pneumoniae are still a serious concern and mucoid-type S. \xa0 pneumoniae with novel phenotype could emerge via capsular switching in response to environmental changes such as introduction of vaccines and improper use of antimicrobial agents .',
  'Community-acquired pneumonia ( CAP ) is a serious social and medical problem in the elderly .',
  'Penicillin resistant pneumococcal infection -- a serious concern for India .',
  'Pneumococcal infection being one of the dominant causes of acute respiratory diseases and exacerbation of chronic ones is a serious problem for human health and society .',
  'The increasing incidence of macrolide- and tetracycline-resistant pneumococci among children has been a serious problem in China for many years .',
  'Penicillin-resistant Streptococcus pneumoniae is a serious concern worldwide .',
  'Whether patients who had AF would be susceptible to the development of hospital-acquired pneumonia ( HAP ) is a serious concern but this has not been investigated .',
  'Data confirm that macrolide resistance in pneumococci is a serious problem in many Asian countries .',
  'Antimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide , particularly in Asian countries , despite the introduction of heptavalent pneumococcal conjugate vaccine ( PCV7 ) .',
  'In spite of the availability of potent antibiotics and sophisticated diagnostic techniques , pneumonia continues to be a serious problem among elders .',
  'Pneumonia is a serious problem worldwide .',
  'S. pneumoniae infection remains a serious public health concern despite the availability of vaccines covering up to 23 of more than 94 known serotypes .',
  'Aspiration pneumonia is a serious problem among elderly patients ; it is caused by many risk factors including dysphagia , poor oral hygiene , malnutrition , and sedative medications .',
  'Streptococcal A infections are reemerging as a dangerous clinical problem .',
  'Despite modern antibiotic therapies , pneumococcal pneumonia still remains a serious epidemiologic problem .',
  'The recent emergence of strains of drug-resistant Streptococcus pneumoniae ( DRSP ) is a serious clinical and public health problem .',
  'Streptococcus pneumoniae is a serious public health problem , especially in developing countries , where available vaccines are not part of the vaccination calendar .',
  'The antibiotic resistance of pneumococcus is not currently a severe problem .',
  'In addition , pneumonia in the elderly is a life-threatening problem .',
  'VAP is a serious problem in ICU carrying many risks for the patient live .',
  'Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine , but the immunophysiological processes that confer either protection or morbidity are not completely understood .',
  'Macrolide resistance in Bordetella pertussis is a serious problem in Zhejiang Province , China .',
  'Emergent resistance to antibiotics among Streptococcus pneumoniae isolates is a severe problem worldwide .',
  'Bacterial infections caused by Group A Streptococcus ( GAS ) are a serious health care concern that currently can not be prevented by vaccination .',
  'Pneumococcal disease is a serious global public health problem and a leading cause of morbidity and mortality of children and adults in China .',
  'Pneumocystis pneumonia complicating immunosuppressive therapy in Crohns disease : A preventable problem ?',
  'Environmental streptococci are a severe problem .',
  'PSGN continues to be a serious public health concern in third world countries , but the incidence of streptococcal infections has steadily declined in industrialized nations .'],
 'pneumoniae': ['In non-pregnant adults, the incidence of invasive Group B Streptococcus (GBS) disease is continuously increasing.',
  'Pneumococcal conjugate vaccines have reduced the incidence of invasive pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a concern',
  'Antimicrobial resistance of Streptococcus pneumoniae, especially against β-lactam antibiotics, is a global concern',
  'An inherent problem with the new pneumococcal conjugate vaccines is that , while more than 20 pneumococcal serotypes may cause invasive disease , only a more limited number of polysaccharides , 11 or so , can in practice be conjugated to carrier protein as part of a single vaccine formulation .',
  'The investigations detailed in the present paper have dealt chiefly with the first problem and incidentally with the second , and lead to the following conclusions : ( a ) That organisms , not to be distinguished by morphological characters or by any physiological peculiarities from true pneumococci derived from pathologic sources , occur with frequency in the mouths of healthy persons and those suffering from slight inflammations of the naso pharynx , and that the only permissible and legitimate conclusion is that these organisms are true pneumococci .',
  'Infections caused by Streptococcus pneumoniae ( pneumococcus ) are still meaning a serious health problem , about 40 % of community acquired pneumonia ( CAP ) is due to pneumococcal bacteria in adults requiring hospitalization .',
  'Invasive pneumococcal diseases ( IPD ) have become a severe problem of public health worldwide .',
  'Ventilator-associated pneumonia ( VAP ) is a serious and costly clinical problem affecting pediatrics today .',
  'Thus , outbreaks of pneumocystosis are a serious problem among colonies of immunodeficient mice , with important implications for the use of these animals in biomedical research .',
  'Increasing pneumococcal resistance to commonly used antibiotics and multidrug resistance is a serious public health concern .',
  'Pneumonia is a serious global health problem and the leading cause of mortality in children .',
  'We detected and reported the first Japanese case of KPC-2 carbapenemase-producing Klebsiella pneumoniae , of which infection will be a serious problem in the near future in Japan .',
  'Ventilator-associated pneumonia ( VAP ) occurs in a patient treated with mechanical ventilation , and it is neither present nor developing at the time of intubation ; it is a serious problem -- with significant morbidity and mortality rates .',
  'Community-acquired pneumonia in adults is a serious health problem in the ambulatory care setting .',
  'A serious therapeutic problem is posed by the infections caused by streptococci mainly due to their ability to recur .',
  'The diagnosis and the treatment of community-acquired severe pneumonia is still a serious child health problem in developing countries .',
  'Since this time the increasing emergence of penicillin- resistant strains of Streptococcus pneumoniae have been a serious therapeutic problem .',
  'Invasive pneumococcal infections among children are a serious public health problem in many countries , including Turkey .',
  'Ventilator-associated pneumonia ( VAP ) is a serious and costly clinical problem .',
  'The Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae has become a serious problem because the species is wide ranging and there are few treatment options .',
  'Streptococcus pneumoniae infection is a serious problem worldwide and the case fatality rate remains high .',
  'Pneumococcal infections continue to pose a serious medical problem .',
  'Streptococcal toxic shock syndrome is a serious health problem in developed and developing countries .',
  'C. pneumoniae infection is associated with respiratory tract infection and chronic respiratory disease , which is a serious public health concern .',
  'The multiresistance of S. pneumoniae poses a serious therapeutic problem and should make myringotomy and bacteriological sampling obligatory in cases of antibiotic treatment failure .',
  'Pneumococcal disease is a serious global public health problem and a leading cause of morbidity and mortality of children and adults in China .',
  'However , ventilator-associated pneumonia still remains a serious controversy-generating problem in intensive care unit .',
  'Macrolide resistance of the B. pertussis population has been a serious problem in the northern part of China .',
  'The increasing incidence of carbapenemase-producing K. pneumoniae strains ( CP-Kps ) in the last decade has become a serious global healthcare problem .',
  'Unfortunately , protection is raised against a limited number of pneumococcal serotypes , and serotype replacement and subsequent vaccine failure have become a serious concern .',
  'Invasive pneumococcal disease ( IPD ) is a serious problem in some risk groups : patients with stage 4 and 5 chronic kidney disease , stage 3 CKD undergoing immunosuppressive treatment , nephrotic syndrome or diabetes .',
  'Although pneumococcal infection is a serious problem worldwide and has a high mortality rate , the molecular mechanisms underlying the lethality caused by pneumococcus remain elusive .',
  'In Morocco , pediatric pneumonia remains a serious public health problem , as it constitutes the first cause of mortality due to infectious diseases .',
  'Acute pneumonia is a serious problem in the elderly and various risk factors have already been reported , but the involvement of QTc interval prolongation remains uncertain .',
  'Pneumococcal meningitis , which represents the third in frequency among the purulent forms of meningitis , continues to be , in spite of antibiotic therapy , a serious problem due to its high mortality rate , which reaches 50 per cent in patients of advanced age .',
  'Antimicrobial resistant S. pneumoniae has already become a serious problem in China .',
  'Accelerating prevalence of coal workers pneumoconiosis is considered as a serious occupational health problem .',
  'Penicillin prophylaxis against infection by Streptococcus pneumoniae is now routine in young children with homozygous sickle-cell ( SS ) disease and the emergence of penicillin-resistant strains is a serious clinical concern .',
  'Repeated aspiration pneumonia is a serious problem in the elderly .',
  'Community-acquired pneumonia ( CAP ) is a serious health problem in Chile .',
  'IAV pneumonia remains a serious global health problem , and preventative and therapeutic strategies remain limited .',
  '[ Penicillin resistant pneumococcus . A serious problem of public health ] .',
  'The increasing emergence of penicillin-resistant and multidrug-resistant strains of Streptococcus pneumoniae will create a serious therapeutic problem in coming years .',
  'Within the last decade , human infections caused by enterobacteria which produce the Klebsiella pneumoniae carbapenemase ( KPC ) became a serious therapeutic and epidemiological problem worldwide .',
  'Recurrent group A beta-hemolytic streptococcus ( GABHS ) pharyngotonsillitis related to penicillin failure presents a serious clinical problem .',
  'The contamination of C. pneumoniae stock cultures , frequently used in the microimmunofluorescence test , with human pathogens , could pose a serious problem in C. pneumoniae serology .',
  'Along with other multidrug-resistant pathogens previously identified , Streptococcus pneumoniae is becoming a serious concern in hospital and ambulatory care settings .',
  'Streptococcus pneumoniae strains with decreased susceptibility to penicillin have become increasingly prevalent over the past 30 years and are now a serious problem worldwide .',
  'Despite the decreased number of cases among HIV-infected patients over the past decade , Pneumocystis pneumonia continues to be a serious problem in immunodeficient patients with other immunosuppressive conditions .',
  'Aspiration pneumonia is a serious health concern in older patients with schizophrenia .',
  'Community-acquired pneumonia ( CAP ) is a serious clinical problem , causing hospitalization in about 20 % of cases and death in up to 16 % of hospitalized patients .',
  'Pneumococcal infections result in substantial morbidity and mortality among children under 5 years of age ; it is estimated that 1,600,000 deaths occur per year in that age range alone , mostly in developing countries , thus representing a serious public health problem around the globe .',
  'Globally , pneumonia is a serious public health concern and a major cause of mortality and morbidity .',
  'Because Streptococcus pneumoniae is a major pathogen that causes community-acquired lower respiratory tract infections and meningitis in adults and children , antibiotic-resistance in this organism is a serious problem .',
  'Aspiration pneumonia is a serious problem for the elderly institutionalized person , often requiring transfer to a hospital and a lengthy stay there .',
  'Pneumonia continues to be a severe health problem in the United States , responsible for close to 1 million hospital admissions and nearly 140,000 hospital readmissions per year .',
  'Multidrug resistance became a serious concern in the treatment of invasive pneumococcal diseases , especially in Asian countries .',
  'Ventilator-associated pneumonia ( VAP ) is a serious concern for patients in the Neuroscience Intensive Care Unit ( NSICU ) .',
  'An abrupt antimicrobial resistance increase among Streptococcus pneumoniae strains has become a serious therapeutic problem in the recent years .',
  'Our findings indicated that IPDs caused by mucoid-type S. \xa0 pneumoniae are still a serious concern and mucoid-type S. \xa0 pneumoniae with novel phenotype could emerge via capsular switching in response to environmental changes such as introduction of vaccines and improper use of antimicrobial agents .',
  'Carbapenem-resistant Klebsiella pneumoniae ( CRKP ) spread and infections in patients with haematological malignancies are a serious concern especially in endemic areas .',
  'Community-acquired pneumonia ( CAP ) is a serious social and medical problem in the elderly .',
  'Penicillin resistant pneumococcal infection -- a serious concern for India .',
  'Pneumococcal infection being one of the dominant causes of acute respiratory diseases and exacerbation of chronic ones is a serious problem for human health and society .',
  'The increasing incidence of macrolide- and tetracycline-resistant pneumococci among children has been a serious problem in China for many years .',
  'Penicillin-resistant Streptococcus pneumoniae is a serious concern worldwide .',
  'Whether patients who had AF would be susceptible to the development of hospital-acquired pneumonia ( HAP ) is a serious concern but this has not been investigated .',
  'KPC-producing Klebsiella pneumoniae ( KPC-Kp ) represent a serious problem worldwide .',
  'Data confirm that macrolide resistance in pneumococci is a serious problem in many Asian countries .',
  'Antimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide , particularly in Asian countries , despite the introduction of heptavalent pneumococcal conjugate vaccine ( PCV7 ) .',
  'In spite of the availability of potent antibiotics and sophisticated diagnostic techniques , pneumonia continues to be a serious problem among elders .',
  'Pneumonia is a serious problem worldwide .',
  'S. pneumoniae infection remains a serious public health concern despite the availability of vaccines covering up to 23 of more than 94 known serotypes .',
  'Aspiration pneumonia is a serious problem among elderly patients ; it is caused by many risk factors including dysphagia , poor oral hygiene , malnutrition , and sedative medications .',
  'Streptococcal A infections are reemerging as a dangerous clinical problem .',
  'The emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management .',
  'Despite modern antibiotic therapies , pneumococcal pneumonia still remains a serious epidemiologic problem .',
  'The recent emergence of strains of drug-resistant Streptococcus pneumoniae ( DRSP ) is a serious clinical and public health problem .',
  'Streptococcus pneumoniae is a serious public health problem , especially in developing countries , where available vaccines are not part of the vaccination calendar .',
  'Carbapenem-resistant Klebsiella pneumoniae ( CRKP ) infection is a serious problem in hospitals worldwide , posing a particular risk to immunocompromised patients .',
  'The antibiotic resistance of pneumococcus is not currently a severe problem .',
  'In addition , pneumonia in the elderly is a life-threatening problem .',
  'VAP is a serious problem in ICU carrying many risks for the patient live .',
  'Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine , but the immunophysiological processes that confer either protection or morbidity are not completely understood .',
  'The spread of carbapenemase-producing Klebsiella pneumoniae ( CPKP ) worldwide is a serious problem .',
  'Macrolide resistance in Bordetella pertussis is a serious problem in Zhejiang Province , China .',
  'The outbreak of carbapenem-resistant Klebsiella pneumoniae is a serious public health problem , especially in the neonatal intensive care unit (NICU).Fifteen K. pneumoniae strains were isolated from 7 neonates during June 3 to 28 , 2017 in an NICU .',
  'Emergent resistance to antibiotics among Streptococcus pneumoniae isolates is a severe problem worldwide .',
  'Bacterial infections caused by Group A Streptococcus ( GAS ) are a serious health care concern that currently can not be prevented by vaccination .',
  'Pneumococcal disease is a serious global public health problem and a leading cause of morbidity and mortality of children and adults in China .',
  'Pneumocystis pneumonia complicating immunosuppressive therapy in Crohns disease : A preventable problem ?',
  'Environmental streptococci are a severe problem .',
  'PSGN continues to be a serious public health concern in third world countries , but the incidence of streptococcal infections has steadily declined in industrialized nations .'],
 'streptococcus': ['In non-pregnant adults, the incidence of invasive Group B Streptococcus (GBS) disease is continuously increasing.',
  'Pneumococcal conjugate vaccines have reduced the incidence of invasive pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a concern',
  'Antimicrobial resistance of Streptococcus pneumoniae, especially against β-lactam antibiotics, is a global concern',
  'An inherent problem with the new pneumococcal conjugate vaccines is that , while more than 20 pneumococcal serotypes may cause invasive disease , only a more limited number of polysaccharides , 11 or so , can in practice be conjugated to carrier protein as part of a single vaccine formulation .',
  'The investigations detailed in the present paper have dealt chiefly with the first problem and incidentally with the second , and lead to the following conclusions : ( a ) That organisms , not to be distinguished by morphological characters or by any physiological peculiarities from true pneumococci derived from pathologic sources , occur with frequency in the mouths of healthy persons and those suffering from slight inflammations of the naso pharynx , and that the only permissible and legitimate conclusion is that these organisms are true pneumococci .',
  'Infections caused by Streptococcus pneumoniae ( pneumococcus ) are still meaning a serious health problem , about 40 % of community acquired pneumonia ( CAP ) is due to pneumococcal bacteria in adults requiring hospitalization .',
  'Invasive pneumococcal diseases ( IPD ) have become a severe problem of public health worldwide .',
  'Ventilator-associated pneumonia ( VAP ) is a serious and costly clinical problem affecting pediatrics today .',
  'Thus , outbreaks of pneumocystosis are a serious problem among colonies of immunodeficient mice , with important implications for the use of these animals in biomedical research .',
  'Increasing pneumococcal resistance to commonly used antibiotics and multidrug resistance is a serious public health concern .',
  'Pneumonia is a serious global health problem and the leading cause of mortality in children .',
  'Ventilator-associated pneumonia ( VAP ) occurs in a patient treated with mechanical ventilation , and it is neither present nor developing at the time of intubation ; it is a serious problem -- with significant morbidity and mortality rates .',
  'Community-acquired pneumonia in adults is a serious health problem in the ambulatory care setting .',
  'A serious therapeutic problem is posed by the infections caused by streptococci mainly due to their ability to recur .',
  'The diagnosis and the treatment of community-acquired severe pneumonia is still a serious child health problem in developing countries .',
  'Since this time the increasing emergence of penicillin- resistant strains of Streptococcus pneumoniae have been a serious therapeutic problem .',
  'Invasive pneumococcal infections among children are a serious public health problem in many countries , including Turkey .',
  'Ventilator-associated pneumonia ( VAP ) is a serious and costly clinical problem .',
  'Streptococcus pneumoniae infection is a serious problem worldwide and the case fatality rate remains high .',
  'Pneumococcal infections continue to pose a serious medical problem .',
  'Streptococcal toxic shock syndrome is a serious health problem in developed and developing countries .',
  'C. pneumoniae infection is associated with respiratory tract infection and chronic respiratory disease , which is a serious public health concern .',
  'The multiresistance of S. pneumoniae poses a serious therapeutic problem and should make myringotomy and bacteriological sampling obligatory in cases of antibiotic treatment failure .',
  'Pneumococcal disease is a serious global public health problem and a leading cause of morbidity and mortality of children and adults in China .',
  'However , ventilator-associated pneumonia still remains a serious controversy-generating problem in intensive care unit .',
  'Macrolide resistance of the B. pertussis population has been a serious problem in the northern part of China .',
  'Unfortunately , protection is raised against a limited number of pneumococcal serotypes , and serotype replacement and subsequent vaccine failure have become a serious concern .',
  'Invasive pneumococcal disease ( IPD ) is a serious problem in some risk groups : patients with stage 4 and 5 chronic kidney disease , stage 3 CKD undergoing immunosuppressive treatment , nephrotic syndrome or diabetes .',
  'Although pneumococcal infection is a serious problem worldwide and has a high mortality rate , the molecular mechanisms underlying the lethality caused by pneumococcus remain elusive .',
  'In Morocco , pediatric pneumonia remains a serious public health problem , as it constitutes the first cause of mortality due to infectious diseases .',
  'Acute pneumonia is a serious problem in the elderly and various risk factors have already been reported , but the involvement of QTc interval prolongation remains uncertain .',
  'Pneumococcal meningitis , which represents the third in frequency among the purulent forms of meningitis , continues to be , in spite of antibiotic therapy , a serious problem due to its high mortality rate , which reaches 50 per cent in patients of advanced age .',
  'Antimicrobial resistant S. pneumoniae has already become a serious problem in China .',
  'Accelerating prevalence of coal workers pneumoconiosis is considered as a serious occupational health problem .',
  'Penicillin prophylaxis against infection by Streptococcus pneumoniae is now routine in young children with homozygous sickle-cell ( SS ) disease and the emergence of penicillin-resistant strains is a serious clinical concern .',
  'Repeated aspiration pneumonia is a serious problem in the elderly .',
  'Community-acquired pneumonia ( CAP ) is a serious health problem in Chile .',
  'IAV pneumonia remains a serious global health problem , and preventative and therapeutic strategies remain limited .',
  '[ Penicillin resistant pneumococcus . A serious problem of public health ] .',
  'The increasing emergence of penicillin-resistant and multidrug-resistant strains of Streptococcus pneumoniae will create a serious therapeutic problem in coming years .',
  'Recurrent group A beta-hemolytic streptococcus ( GABHS ) pharyngotonsillitis related to penicillin failure presents a serious clinical problem .',
  'The contamination of C. pneumoniae stock cultures , frequently used in the microimmunofluorescence test , with human pathogens , could pose a serious problem in C. pneumoniae serology .',
  'Along with other multidrug-resistant pathogens previously identified , Streptococcus pneumoniae is becoming a serious concern in hospital and ambulatory care settings .',
  'Streptococcus pneumoniae strains with decreased susceptibility to penicillin have become increasingly prevalent over the past 30 years and are now a serious problem worldwide .',
  'Despite the decreased number of cases among HIV-infected patients over the past decade , Pneumocystis pneumonia continues to be a serious problem in immunodeficient patients with other immunosuppressive conditions .',
  'Aspiration pneumonia is a serious health concern in older patients with schizophrenia .',
  'Community-acquired pneumonia ( CAP ) is a serious clinical problem , causing hospitalization in about 20 % of cases and death in up to 16 % of hospitalized patients .',
  'Pneumococcal infections result in substantial morbidity and mortality among children under 5 years of age ; it is estimated that 1,600,000 deaths occur per year in that age range alone , mostly in developing countries , thus representing a serious public health problem around the globe .',
  'Globally , pneumonia is a serious public health concern and a major cause of mortality and morbidity .',
  'Because Streptococcus pneumoniae is a major pathogen that causes community-acquired lower respiratory tract infections and meningitis in adults and children , antibiotic-resistance in this organism is a serious problem .',
  'Aspiration pneumonia is a serious problem for the elderly institutionalized person , often requiring transfer to a hospital and a lengthy stay there .',
  'Pneumonia continues to be a severe health problem in the United States , responsible for close to 1 million hospital admissions and nearly 140,000 hospital readmissions per year .',
  'Multidrug resistance became a serious concern in the treatment of invasive pneumococcal diseases , especially in Asian countries .',
  'Ventilator-associated pneumonia ( VAP ) is a serious concern for patients in the Neuroscience Intensive Care Unit ( NSICU ) .',
  'An abrupt antimicrobial resistance increase among Streptococcus pneumoniae strains has become a serious therapeutic problem in the recent years .',
  'Our findings indicated that IPDs caused by mucoid-type S. \xa0 pneumoniae are still a serious concern and mucoid-type S. \xa0 pneumoniae with novel phenotype could emerge via capsular switching in response to environmental changes such as introduction of vaccines and improper use of antimicrobial agents .',
  'Community-acquired pneumonia ( CAP ) is a serious social and medical problem in the elderly .',
  'Penicillin resistant pneumococcal infection -- a serious concern for India .',
  'Pneumococcal infection being one of the dominant causes of acute respiratory diseases and exacerbation of chronic ones is a serious problem for human health and society .',
  'The increasing incidence of macrolide- and tetracycline-resistant pneumococci among children has been a serious problem in China for many years .',
  'Penicillin-resistant Streptococcus pneumoniae is a serious concern worldwide .',
  'Whether patients who had AF would be susceptible to the development of hospital-acquired pneumonia ( HAP ) is a serious concern but this has not been investigated .',
  'Data confirm that macrolide resistance in pneumococci is a serious problem in many Asian countries .',
  'Antimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide , particularly in Asian countries , despite the introduction of heptavalent pneumococcal conjugate vaccine ( PCV7 ) .',
  'In spite of the availability of potent antibiotics and sophisticated diagnostic techniques , pneumonia continues to be a serious problem among elders .',
  'Pneumonia is a serious problem worldwide .',
  'S. pneumoniae infection remains a serious public health concern despite the availability of vaccines covering up to 23 of more than 94 known serotypes .',
  'Aspiration pneumonia is a serious problem among elderly patients ; it is caused by many risk factors including dysphagia , poor oral hygiene , malnutrition , and sedative medications .',
  'Streptococcal A infections are reemerging as a dangerous clinical problem .',
  'Despite modern antibiotic therapies , pneumococcal pneumonia still remains a serious epidemiologic problem .',
  'The recent emergence of strains of drug-resistant Streptococcus pneumoniae ( DRSP ) is a serious clinical and public health problem .',
  'Streptococcus pneumoniae is a serious public health problem , especially in developing countries , where available vaccines are not part of the vaccination calendar .',
  'The antibiotic resistance of pneumococcus is not currently a severe problem .',
  'In addition , pneumonia in the elderly is a life-threatening problem .',
  'VAP is a serious problem in ICU carrying many risks for the patient live .',
  'Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine , but the immunophysiological processes that confer either protection or morbidity are not completely understood .',
  'Macrolide resistance in Bordetella pertussis is a serious problem in Zhejiang Province , China .',
  'Emergent resistance to antibiotics among Streptococcus pneumoniae isolates is a severe problem worldwide .',
  'Bacterial infections caused by Group A Streptococcus ( GAS ) are a serious health care concern that currently can not be prevented by vaccination .',
  'Pneumococcal disease is a serious global public health problem and a leading cause of morbidity and mortality of children and adults in China .',
  'Pneumocystis pneumonia complicating immunosuppressive therapy in Crohns disease : A preventable problem ?',
  'Environmental streptococci are a severe problem .',
  'PSGN continues to be a serious public health concern in third world countries , but the incidence of streptococcal infections has steadily declined in industrialized nations .'],
 'leprosy': ['Leprosy is an ancient infectious disease with a global annual incidence that has plateaued above 200,000 new cases since over a decade.',
  'due to late diagnosis and higher frequency of treatment abandonment leprosy is a serious public health problem among children and adolescents',
  'Leprosy is a serious public health problem in peripheral and developing countries .',
  'Leprosy is one of the oldest diseases of humanity and persists as a serious public health problem .',
  'Although the prevalence rate of leprosy in the Republic of Yemen has dropped below the WHO elimination level of less than one case per 10,000 of the population , it is still regarded as a serious public health problem calling for continued vigilance , notably in the detection and treatment of hidden and undiagnosed cases .',
  "Leprosy , also known as Hansen 's disease , is a long-term infection by the bacteria Mycobacterium leprae , and actually still persists as a serious public health problem .",
  'By the middle of the 19th century , leprosy was a serious public health problem in Norway .',
  'Leprosy is a chronic , degenerative and curable infectious illness that continues to be a serious public health problem , mainly in the poorest region of Brazil .',
  'This paper discusses the issue of defaulters with paucibacillary leprosy and the findings of the study suggest that defaulters with paucibacillary leprosy are not a serious problem in terms of leprosy control .',
  'During the 19th century leprosy was a serious health problem in Norway , especially in some western , rural districts .',
  'Plantar ulcers present a serious problem in the management of leprosy .',
  'Mycobacterium leprae is responsible for leprosy , a type of chronic inflammatory disease that existed from ancient times , still hearing the name of leprosy creates an awful imagination of cutting the organ , blindness and isolation and it has still remained as a serious social problem .',
  'Although Iran is currently an area in which leprosy is not a serious problem , new cases of leprosy are still diagnosed in Iran .',
  'This means that leprosy continues to represent a serious public and individual health problem in Africa .',
  'Leprosy , a chronic infectious disease , poses a serious public health concern due to its impact on the wellbeing of affected people .',
  'Leprosy in children under 15 years of age is a serious public health problem .',
  'Leprosy remains a serious public health problem due to its ability to cause disability .',
  'Leprosy was a serious public health problem in Zambia until recently , with over 16,000 cases in 1982 .',
  'Leprosy still represents a serious health problem in a number of countries , including Brazil .',
  'Leprosy is a chronic disease , caused by Mycobacterium leprae , which poses a serious public health problem worldwide .',
  'The infectious complications were concluded to present a serious problem in the treatment of leucosis , due to which their diagnosis is of essential importance for their early diagnosis , timely treatment and prophylaxis .',
  'The present results also show that relapse of leprosy is acceptably low and has not yet become a serious clinical or public health problem but , based upon the incubation of relapse in MDT patients , it is necessary to encourage annual follow up for at least 5 years for paucibacillary ( PB ) and 10 years for MB patients after being released from WHO/MDT .',
  'Lagophthalmos continues to be a serious problem in cured leprosy patients .',
  'Leprosy can not be considered to be a serious public health problem in the country .',
  'Despite achieving the goal of national elimination of leprosy , it remains a serious public health problem in the high prevalence states of Uttar Pradesh , Bihar and Orissa .'],
 'cleft': ['Craniofacial clefts are one of the rarest congenital malformations',
  'WRV flap aims to high light the importance of achieving a near normal look of the cleft patient with the only drawback of associated learning curve with this technique .',
  'In this paper , we present the case of a 24-year-old patient with a diagnosis of cerebral palsy and a severe problem of drooling , exacerbated by marked mandibular prognathism .',
  'Cleft palate patients with a severe maxillary hypoplasia can pose a very challenging problem for the surgeon .',
  'Besides conductive hearing loss hyper nasality remains a serious problem in 30 - 50 % of the children with cleft palate .',
  'Bilateral cleft lip and palate patients may present a vertical excess of the premaxilla , which is a severe aesthetic and functional problem .',
  'The scar that occurs after cleft lip surgery poses a serious cosmetic problem .',
  'Aesthetic changes in the aging upper lip constitute a troublesome problem for modern women .',
  'Correction of severe short nose is a distressing problem for plastic surgeons .',
  'Atypical facial clefts are rare congenital anomalies , however because of functional and aesthetic disturbances they constitute a serious medical and therapeutic problem .',
  'Cleft lip/palate is the second most observed congenital defect which constitutes a serious dental-medical-social problem .',
  'While esthetic and functional outcomes of treatment have improved for patients with cleft lip and palate ( CLP ) , a CLP remains a severe problem for patients and relatives .',
  'The repair of fronto-orbital nasal bone defects may be a troublesome problem to plastic surgeons .'],
 'palate': ['Craniofacial clefts are one of the rarest congenital malformations',
  'WRV flap aims to high light the importance of achieving a near normal look of the cleft patient with the only drawback of associated learning curve with this technique .',
  'In this paper , we present the case of a 24-year-old patient with a diagnosis of cerebral palsy and a severe problem of drooling , exacerbated by marked mandibular prognathism .',
  'Cleft palate patients with a severe maxillary hypoplasia can pose a very challenging problem for the surgeon .',
  'Besides conductive hearing loss hyper nasality remains a serious problem in 30 - 50 % of the children with cleft palate .',
  'Bilateral cleft lip and palate patients may present a vertical excess of the premaxilla , which is a severe aesthetic and functional problem .',
  'The scar that occurs after cleft lip surgery poses a serious cosmetic problem .',
  'Aesthetic changes in the aging upper lip constitute a troublesome problem for modern women .',
  'Correction of severe short nose is a distressing problem for plastic surgeons .',
  'Atypical facial clefts are rare congenital anomalies , however because of functional and aesthetic disturbances they constitute a serious medical and therapeutic problem .',
  'Cleft lip/palate is the second most observed congenital defect which constitutes a serious dental-medical-social problem .',
  'While esthetic and functional outcomes of treatment have improved for patients with cleft lip and palate ( CLP ) , a CLP remains a severe problem for patients and relatives .',
  'The repair of fronto-orbital nasal bone defects may be a troublesome problem to plastic surgeons .'],
 'lip': ['Craniofacial clefts are one of the rarest congenital malformations',
  'WRV flap aims to high light the importance of achieving a near normal look of the cleft patient with the only drawback of associated learning curve with this technique .',
  'In this paper , we present the case of a 24-year-old patient with a diagnosis of cerebral palsy and a severe problem of drooling , exacerbated by marked mandibular prognathism .',
  'Cleft palate patients with a severe maxillary hypoplasia can pose a very challenging problem for the surgeon .',
  'Besides conductive hearing loss hyper nasality remains a serious problem in 30 - 50 % of the children with cleft palate .',
  'Bilateral cleft lip and palate patients may present a vertical excess of the premaxilla , which is a severe aesthetic and functional problem .',
  'The scar that occurs after cleft lip surgery poses a serious cosmetic problem .',
  'Aesthetic changes in the aging upper lip constitute a troublesome problem for modern women .',
  'Correction of severe short nose is a distressing problem for plastic surgeons .',
  'Atypical facial clefts are rare congenital anomalies , however because of functional and aesthetic disturbances they constitute a serious medical and therapeutic problem .',
  'Cleft lip/palate is the second most observed congenital defect which constitutes a serious dental-medical-social problem .',
  'While esthetic and functional outcomes of treatment have improved for patients with cleft lip and palate ( CLP ) , a CLP remains a severe problem for patients and relatives .',
  'The repair of fronto-orbital nasal bone defects may be a troublesome problem to plastic surgeons .'],
 'clefts': ['Craniofacial clefts are one of the rarest congenital malformations',
  'WRV flap aims to high light the importance of achieving a near normal look of the cleft patient with the only drawback of associated learning curve with this technique .',
  'In this paper , we present the case of a 24-year-old patient with a diagnosis of cerebral palsy and a severe problem of drooling , exacerbated by marked mandibular prognathism .',
  'Cleft palate patients with a severe maxillary hypoplasia can pose a very challenging problem for the surgeon .',
  'Besides conductive hearing loss hyper nasality remains a serious problem in 30 - 50 % of the children with cleft palate .',
  'Bilateral cleft lip and palate patients may present a vertical excess of the premaxilla , which is a severe aesthetic and functional problem .',
  'The scar that occurs after cleft lip surgery poses a serious cosmetic problem .',
  'Aesthetic changes in the aging upper lip constitute a troublesome problem for modern women .',
  'Correction of severe short nose is a distressing problem for plastic surgeons .',
  'Atypical facial clefts are rare congenital anomalies , however because of functional and aesthetic disturbances they constitute a serious medical and therapeutic problem .',
  'Cleft lip/palate is the second most observed congenital defect which constitutes a serious dental-medical-social problem .',
  'While esthetic and functional outcomes of treatment have improved for patients with cleft lip and palate ( CLP ) , a CLP remains a severe problem for patients and relatives .',
  'The repair of fronto-orbital nasal bone defects may be a troublesome problem to plastic surgeons .'],
 'congenital': ['Craniofacial clefts are one of the rarest congenital malformations',
  'WRV flap aims to high light the importance of achieving a near normal look of the cleft patient with the only drawback of associated learning curve with this technique .',
  'Syphilis is a multistage sexually transmitted disease that remains a serious public health concern worldwide .',
  'Syphilis continues to be a serious public health problem worldwide , even if it is a controllable disease due to diagnostic tests and effective and accessible treatment .',
  'A serious problem of " gravidic syphilis " suggests the need for Public Health preventive action .',
  'In this paper , we present the case of a 24-year-old patient with a diagnosis of cerebral palsy and a severe problem of drooling , exacerbated by marked mandibular prognathism .',
  'Cleft palate patients with a severe maxillary hypoplasia can pose a very challenging problem for the surgeon .',
  'Besides conductive hearing loss hyper nasality remains a serious problem in 30 - 50 % of the children with cleft palate .',
  'Bilateral cleft lip and palate patients may present a vertical excess of the premaxilla , which is a severe aesthetic and functional problem .',
  'Congenital syphilis is the oldest recognized congenital infection and still represents a serious healthcare problem in the 21st century .',
  'Congenital syphilis is a preventable disease and treatable infection in the modern world , but we are still met with challenges in its eradication .',
  'The scar that occurs after cleft lip surgery poses a serious cosmetic problem .',
  'Persistent syphilis in this population of FSWs is a serious public health concern .',
  'Aesthetic changes in the aging upper lip constitute a troublesome problem for modern women .',
  'The infection rate of syphilis in China has increased dramatically in recent decades , becoming a serious public health concern .',
  'Correction of severe short nose is a distressing problem for plastic surgeons .',
  'Brazil has reported an increase in the incidence of both gestational and congenital syphilis , posing a serious public health problem in the country .',
  'Syphilis poses a serious health problem in many developing countries and in some areas of North America and Europe , especially Eastern Europe .',
  'This study illustrates that , despite being a preventable infection , syphilis remains a public health problem .',
  'Syphilis transmission among IDUs in Los Angeles County remains a serious public health concern , particularly among IDUs who engage in trading of sex for money or drugs .',
  'Atypical facial clefts are rare congenital anomalies , however because of functional and aesthetic disturbances they constitute a serious medical and therapeutic problem .',
  'Cleft lip/palate is the second most observed congenital defect which constitutes a serious dental-medical-social problem .',
  'While esthetic and functional outcomes of treatment have improved for patients with cleft lip and palate ( CLP ) , a CLP remains a severe problem for patients and relatives .',
  'In Morocco , neurosyphilis is a serious public health problem .',
  'The repair of fronto-orbital nasal bone defects may be a troublesome problem to plastic surgeons .',
  'Congenital syphilis is considered a severe public health problem because it accounts for approximately 40 % of the perinatal mortality rates , 25 % of stillbirths , and 14 % of neonatal deaths , in addition to causing severe consequences for the fetus .'],
 'tuberculosis': ['Health care workers (HCWs) are globally known to have high risk of tuberculosis (TB) infection while risk factors of TB infections among HCWs are still inconclusive',
  'Pulmonary tuberculosis (PTB) is a major health and economic burden',
  'The problem with the emergence of HIV-associated tuberculosis ( which usually occurs in young adults ) is that attention has been diverted away from the fact that , in the developed world , the elderly represent the biggest pool of tubercular disease and therefore the greatest pool of infection within the community .',
  'Importance : A major drawback of current TB chemotherapy is its long duration .',
  'The treatment regimen of HIV-TB coinfection is associated with a major drawback of low therapeutic concentration of drugs in lungs .',
  'Despite being a powerful frontline tuberculosis drug , INH has the potential drawback of inducing its own stable genetic resistance in INH-tolerant persisters .',
  'MDR and XDR tuberculosis are associated with high morbidity and substantial mortality , are a threat to health-care workers , prohibitively expensive to treat , and are therefore a serious public health problem .',
  'In recent years tuberculosis has reemerged as a serious public health problem , raising the possibility that tuberculous eye disease may also become more prevalent .',
  'Co-infection of tuberculosis ( TB ) and HIV is a serious problem in most developing countries and in industrialized countries , co-infection of TB and HIV is seen mainly among migrant population .',
  'The emergence of new strains of Mycobacterium tuberculosis resistant to some or all current antituberculosis drugs is a serious and crescent problem .',
  'Pulmonary tuberculosis ( TB ) remains a serious health problem worldwide .',
  'Tuberculosis ( TB ) remains a serious concern more than two decades on from when the World Health Organization declared it a global health emergency .',
  'Tuberculosis ( TB ) is a serious public health problem worldwide , particularly in developing countries .',
  'Tuberculosis continues to be a serious health problem worldwide .',
  'The rising occurrence of multidrug-resistant tuberculosis ( MDR-TB ) , defined as resistance to at least isoniazid and rifampicin , is a serious worldwide problem .',
  'Tuberculosis is an infectious disease , which is the leading cause of mortality and morbidity and is still a serious health concern .',
  'Intracranial tuberculosis continues to be a serious problem in both the developing and developed world , with significant morbidity and mortality .',
  'Tuberculosis ( TB ) is a severe problem in underdeveloped countries .',
  'Unemployment among TB patients is a serious problem .',
  'Multidrug-resistant tuberculosis continues to be a serious problem , particularly among some countries of eastern Europe .',
  'Multi-drug resistant tuberculosis is a serious clinical problem .',
  'The result of this study indicated that MDR-TB is a serious public health problem in Ethiopia .',
  'Tuberculosis in refugee centres is a serious problem that needs adequate attention .',
  'Tuberculosis ( TB ) is a serious public health problem worldwide .',
  'Tuberculosis ( TB ) is a serious public health problem in many parts of the world .',
  'Tuberculosis ( TB ) continues to be a serious global health problem .',
  'The MDR ( multidrug resistance ) tuberculosis is a serious public health concern .',
  'Tuberculosis ( TB ) is a serious public health problem in developing countries such as Pakistan .',
  'Although mammalian tuberculosis has been nearly controlled in many developed countries , it is still a serious problem in humans and domestic animals including pigs in developing countries .',
  'The startling increase in the occurrence of rifampicin ( Rif ) resistance in the clinical isolates of Mycobacterium tuberculosis worldwide is posing a serious concern to tuberculosis management .',
  'Multidrug-resistant tuberculosis ( MDR-TB ) is a serious health problem in Eastern European countries , including Latvia .',
  'The prevalence and distribution of drug-resistant TB remains a serious public health problem in Ethiopia .',
  'The incidence of tuberculosis has reduced in Japan , but the slowing down in the rate of decrease of the incidence was pointed , and this tendency is a severe problem in the tuberculosis control .',
  'Emergence of multi-drug resistance tuberculosis has become a serious health problem globally .',
  'The rate of new cases of multidrug resistant tuberculosis ( MDRTB ) continues to increase , and since these infections are very difficult to manage , they constitute a serious health problem .',
  'Tuberculosis ( TB ) is a serious problem for patients undergoing haematopoietic stem cell transplantation ( HSCT ) in TB-endemic areas ; however , data on these patients are limited .',
  'Multidrug-resistant tuberculosis ( MDR-TB ) is a serious problem in the former Soviet Union and may appear during TB treatment .',
  'The selection and soaring spread of Mycobacterium tuberculosis multidrug-resistant ( MDR-TB ) and extensively drug-resistant strains ( XDR-TB ) is a severe public health problem .',
  'We conclude that emergence of drug resistant tuberculosis has the potential to be a serious public health problem in Sudan and that strengthened tuberculosis control and improved monitoring of therapy is needed .',
  'Multidrug resistant tuberculosis ( MDR-TB ) still continues to be a serious health problem throughout the world .',
  'Drug-resistant tuberculosis ( TB ) is a serious global problem , and pathogen factors involved in the transmission of isoniazid (INH)-resistant TB have not been fully investigated .',
  'Tuberculosis remains a serious global health problem .',
  'The management of persons exposed to and infected by patients with MDR-TB has become a serious problem in the context of MDR-TB outbreaks .',
  'In recent years , however , tuberculosis has reemerged as a serious public health problem .',
  "In Côte d'Ivoire , multidrug-resistant tuberculosis ( MDR-TB ) is a serious public health problem with a prevalence estimated at 2.5 % in 2006 .",
  'In settings where TB continues being a serious health problem , cost-effectiveness evaluations would privilege TST under certain conditions : supply of quality-assured PPD reagent , standardized criteria for TST application , reading and interpretation , and regular availability in health centers countrywide .',
  'Hence , tuberculosis is once again a serious global problem not only in the developing countries of Africa or South East Asia , but also in highly-developed communities .',
  'The developing world is facing a serious problem of tuberculosis ( TB ) since ages .',
  'Central nervous system ( CNS ) tuberculosis is a serious clinical problem , the treatment of which is sometimes hampered by delayed diagnosis .',
  'Multi-drug resistant tuberculosis ( MDR-TB ) is emerging as a serious global health problem , which has been elevated through co-infection involving HIV and MDR-Mtb .',
  "The study concludes that ' system ' delay is a serious problem , which is influenced by the financing mechanisms for both TB control and general health services as well as poverty and disadvantage amongst patients .",
  'Even more alarming is the increasing incidence of multidrug-resistant tuberculosis which presents a serious public health problem , particularly for HIV-infected patients .',
  'Extensively drug-resistant ( XDR ) tuberculosis ( TB ) represents a serious and growing problem in both endemic and non-endemic countries .',
  'Multidrug-resistant tuberculosis in children is a severe form of tuberculosis , which remains a major health problem especially in developing countries .',
  'Tuberculosis ( TB ) is still a serious public health problem , continuing to be an important threat for confined populations .',
  'Recently , tuberculosis re-emerged as a serious public health problem , in industrialized countries , while remaining it remains a major cause of mortality and morbidity in third world countries .',
  'Although Galicia has a high incidence of TB ( 49.4 cases per 100 000 population in 2001 ) , the resistance levels detected by the study do not currently pose a serious problem for the region .',
  'According to the official domestic statistics pulmonary tuberculosis continues to be a serious problem for the Russian Federation .',
  'Multidrug-resistant tuberculosis ( MDRTB ) is a serious world health problem that limits public actions to control tuberculosis , because the most used anti-tuberculosis first-line drugs fail to stop mycobacterium spread .',
  'Tuberculosis continues to be a serious public health problem worldwide .',
  'Tuberculosis has re-emerged as a serious public health problem in recent years .',
  'Despite the use of bacille Calmette-Guérin ( BCG ) for almost a century , pulmonary tuberculosis ( TB ) continues to be a serious global health concern .',
  '< sec > < title > BACKGROUND</title > Tuberculosis ( TB ) remains a serious health problem worldwide .',
  'Tuberculosis is a serious problem of public health .',
  'Tuberculosis ( TB ) remains a serious public health problem despite the great scientific advances in the recent decades .',
  'At a time when reduction in Federal support for tuberculosis control is being considered , it is important to realize that the disease remains a serious medical problem and financial burden in the United States .',
  'Drug resistant tuberculosis is a serious problem in control of tuberculosis .',
  'Tuberculosis ( TB ) remains a serious global public health problem that results in up to 2 million deaths each year .',
  'Mycobacterial disease remains a serious global health problem .',
  'Tuberculosis remains a serious health problem worldwide , particularly affecting the poorest in both high-income and developing countries .',
  'The high prevalence of diabetes mellitus ( DM ) among multidrug resistant tuberculosis ( MDR-TB ) patients is a serious cause for concern .',
  'The emergence of drug resistant tuberculosis poses a serious concern globally and researchers are in rigorous search for new drugs to fight against these dreadful bacteria .',
  'Tuberculosis ( TB ) is a serious world-wide health problem , causing millions of deaths every year .',
  'Tuberculosis ( TB ) is a serious health problem in Papua New Guinea ( PNG ) with an estimated 30000 new cases and 3800 deaths each year .',
  "Tuberculosis ( TB ) presents a serious health problem with approximately one-third of the world 's population infected with",
  'The pandemic spread of tuberculosis ( TB ) and human immunodeficiency virus ( HIV ) represents a serious world problem .',
  'Tuberculosis ( TB ) remains a serious public health problem in spite of DOTS programme recommended by WHO .',
  'Extensively drug-resistant tuberculosis ( XDR-TB ) is a serious worldwide problem .',
  'Tuberculosis remains a severe public health problem , and is a major cause of infant disease in North Lebanon .',
  'This case reminds us that correct diagnosis of tuberculosis remains a serious problem despite the long experience and the development of diagnostics and treatment methods .',
  'Mycobacterial disease remains a serious international public health concern .',
  'Many researchers have done a lot of research and achieved remarkable results , but TB is still a severe problem for human beings .',
  'Tuberculosis ( TB ) , a dreadful disease known to mankind continues to be a problem in a developing country like India .',
  "Nigeria has the world 's fourth largest tuberculosis burden , and multidrug resistant tuberculosis ( MDR-TB ) represents a serious public health problem .",
  'The emergence of drug-resistant strains of Mycobacterium tuberculosis is a serious public health problem .',
  'Tuberculosis continues to be a serious problem in public health even thought eh causative bacillus was discovered over 100 years ago .',
  'Tuberculosis is a serious health problem in India , but because of inadequate facilities for diagnosis in many parts of the country clinical data are incomplete .',
  'The aim of this study was to evaluate the percentage and characteristics of extrapulmonary tuberculosis ( EPTB ) cases in a Turkish industrial city , Kocaeli ( population : 1,203,335 ) and to illustrate its extent as a serious health problem for this city and country .',
  'Worldwide , tuberculosis ( TB ) is still a serious and significant health concern , more so with the emergence of multidrug-resistant-TB .',
  "Tuberculosi remains a serious public health problem in the Americas , and it has not declined as rapidly or as much as experts projected it would in the 1940 's .",
  'The basic epidemiological parameters ( prevalence , incidence , mortality due to tuberculosis ) and inadequate efficiency of treatment of patients suggest that tuberculosis remains to be a serious problem in the North-West of Russia .',
  'Extrapulmonary tuberculosis : a debilitating and often neglected public health problem .',
  'Tuberculosis ( TB - Mycobacterium tuberculosis ) is an ancient infectious disease that has appeared once again as a serious worldwide health problem and now comprises the second leading cause of death resulting from a single infection .',
  'Poor performance of Mantoux test is a serious concern and requires the attention of TB programme managers and other relevant authorities .',
  'It has a severe tuberculosis ( TB ) problem , with a new tuberculosis case notification rate , all forms , of about 150 per 100000 population and a tuberculosis programme , established in the early 1980s , achieving cure rates of only 40 - 50 % in the last decade .',
  'Tuberculosis may be as old as mankind and continues to be a serious medical problem today .',
  'Tuberculosis historically was a major impetus for the development of thoracic surgery , and it remains a serious health problem of global proportion .',
  'Peritoneal tuberculosis ( PTB ) , although rarer than its pulmonary counterpart , is a serious health concern in regions of the world with high tuberculosis prevalence .',
  'The increasing number of sputum smear- and culture-negative TB patients is a serious concern because misdiagnosis and delayed treatment can lead to increased morbidity and mortality and increased infectious transmission .',
  "The incidence of tuberculosis has decreased in Japan , and , many doctors did not show concern on , thus , a doctor 's delay is a serious problem in Japan .",
  'Multidrug-resistant ( MDR ) tuberculosis , defined as tuberculosis resistant to the two first-line drugs isoniazid and rifampin , poses a serious problem for global tuberculosis control strategies .',
  'Tuberculosis currently remains a serious medical problem , therefore increased attention is being paid to this disease .',
  'To this end , reactivation of latent tuberculosis infection represents a serious concern of anti-TNFalpha antibody therapy .',
  'Tuberculosis ( TB ) remains a serious health problem responsible to cause millions of deaths annually .',
  'TB is a serious global public health problem .',
  'Multidrug-resistant strains of Mycobacterium tuberculosis are a serious and continuing human health problem .',
  'Multidrug resistant tuberculosis ( MDR-TB ) remains a serious public health problem with poor treatment outcomes .',
  'Patient delay appears to be a serious problem in this rural area with a high prevalence of tuberculosis .',
  'Bone and joint tuberculosis is a serious medical problem ; tuberculosis of sternoclavicular joint is rare .',
  'Tuberculosis involvement of the central nervous system continues to represent a serious problem , particularly in developing countries .',
  'Tuberculosis ( TB ) is still a severe public health problem ; the current diagnostic tests have limitations that delay treatment onset .',
  'Tuberculosis , caused by Mycobacterium tuberculosis , is a serious infectious disease and remains a global health problem .',
  'Tuberculosis ( TB ) continues to be a serious public health problem and establishing a definitive diagnosis among children is extremely challenging .',
  'Tuberculosis remains a serious social and public health problem , affecting millions of people annually .',
  'Tuberculosis ( TB ) is a serious re-emergent public health problem in the UK .',
  'Unsuccessful TB treatment outcome is a serious public health concern .',
  'Tuberculosis ( TB ) is an infectious , devastating and contagious disease , which infects third of the global population worldwide with high rates of incidence in the developing countries , where   the health care providers face   a serious problem and a real challenge during their clinical practice for controlling and preventing the transmission of this illness .',
  'Although TBE is a serious problem in Latvia , the knowledge concerning TBE virus ( TBEV ) strains circulating in the country is most limited .',
  '11(6 ) , 435 - 444 (2011).Tuberculosis ( TB ) is a serious public health problem in the UK , and detection and prophylactic treatment of latent infection offers improved control .',
  'MDR-TB are defined as strains which are resistant to at least isoniazid ( INH ) and rifampicin , the two most potent TB drugs , and their increasing incidence is a serious concern .',
  'The drug susceptibility profile developed in the present study indicates that drug-resistant tuberculosis is emerging as a serious public health concern in Sahariya tribe .',
  'Tuberculosis ( TB ) has reappeared as a serious public health problem .',
  'Multi-drug resistant ( MDR ) Mycobacterium tuberculosis is still a serious public health problem all over the world .',
  'The fact that a prior BCG scar is not associated with a positive response to the TT indicates the need to re-open discussion of the guidelines which exist in many poor countries where tuberculosis is still a serious public health problem .',
  'Tuberculosis ( TB ) has emerged as a serious public health problem in the country of Georgia .',
  'It is essential to highlight this alarming presentation in a child , as the presence of tuberculosis has re-emerged as a serious public health problem especially in developing countries .',
  'Tuberculosis ( TB ) has become a rare disease in the developed countries but it is still a serious problem in developing countries .',
  'Tuberculosis is still one of the most common infectious diseases along with HIV and malaria and therefore represents a serious problem in the health sector .',
  'There is existing still a serious problem of chronic tuberculosis .',
  'Tuberculosis ( TB ) is a serious public health problem in many regions of the world , especially in the poorest areas .',
  'Drug resistance is a serious problem in the treatment of tuberculosis and a threat to successful tuberculosis control programmes .',
  'Tuberculosis is a serious public health problem worldwide .',
  'However , death among younger patients with TB is also a serious concern , and although several socio-economic factors have been suggested in the past , these studies have varied in methods and results .',
  'This review indicated that MDR-TB in Ethiopia is a serious public health problem that needs to be addressed urgently .',
  'Intrinsic multidrug resistance of the Mycobacterium avium-intracellulare complex presents a serious problem in the treatment of the diseases caused by these bacteria .',
  'Tuberculosis ( TB ) has remained a devastating global public health problem .',
  'TBE is a serious problem in Latvia with up to a 1,000 patients confirmed serologically annually 1994 - 1995 .',
  'Drug-resistant tuberculosis is a serious problem throughout the world .',
  'The increasing rate of appearance of multidrug-resistant strains of Mycobacterium tuberculosis ( MDR-TB ) is a serious problem at the present time .',
  'It may be cautioned that , among infectious diseases , tuberculosis is still a serious health problem today and HIV infection has become a threatening health issue although the number of AIDS patients reported was still about 1,000 for the whole country in 1995 .',
  'Tuberculosis ( TB ) is a serious worldwide public health problem , and drug resistance , particularly multidrug resistance ( MDR ) , is a critical factor involved in TB control .',
  'Drug resistant tuberculosis y a serious problem in Chiapas that requires urgent attention if future control of the disease is to be maintained .',
  "Tuberculosis remains the world 's leading cause of death from an infectious agent , and is a serious health problem in Papua New Guinea ( PNG ) with an estimated 36,000 new cases each year .",
  'Despite decades of research many aspects of the biology of Mycobacterium tuberculosis remain unclear and this is reflected in the antiquated tools available to treat and prevent tuberculosis and consequently this disease remains a serious public health problem .',
  'Having a history as old as the history of humanity , Tuberculosis ( TB ) is a serious disease and it is regarded as an important a public health problem not only for its medical aspect but also for its social and ethical aspects .',
  'XDR-TB has become a serious problem for the health administrations in this region .',
  'Reactivation tuberculosis ( TB ) is a serious problem in immunocompromised individuals , especially those with human immunodeficiency virus ( HIV ) coinfection .',
  'In conclusion , posttransplantation TB is a serious problem worldwide , and a high index of suspicion is warranted to ensure early diagnosis and prompt initiation of treatment for TB among SOT patients .',
  'Tuberculosis poses a global public health threat , and individuals who fail to comply with treatment risk developing drug-resistant strains , which are a serious public health concern .',
  "One third of the world 's population is infected with TB , and in conjunction with HIV represents a serious problem that urgently needs addressing .",
  'TB remains , however , a serious health problem in the CR .',
  'Tuberculosis continues to be a devastating public health problem .',
  'The emergence of resistance in tuberculosis has become a serious problem for the control of this disease .',
  'Tuberculosis is a serious global health problem caused by the bacterium Mycobacterium tuberculosis .',
  'More re-treatment TB patients are notified in India than any other country in the world , and default among this group is a serious public health problem .',
  'The interaction between HIV and M. tuberculosis infection poses a serious health problem which will result in a major increase in disease , death and health care service needs in many countries .',
  'Tuberculosis and multidrug-resistant tuberculosis is a serious public health problem in Russia .',
  'Despite decreasing numbers of cases in the United States since 1992 , TB remains a serious public health problem among certain patient populations and is highly prevalent in many urban areas .',
  'Tuberculosis ( TB ) is a serious public health problem .',
  'Tuberculosis remains a serious human public health concern .',
  'Tuberculosis is a serious public health problem worldwide , particularly in developing countries .',
  'Tuberculosis ( TB ) remains a serious public-health problem worldwide .',
  'The high rate of MDR-TB illustrates a serious problem .',
  'Tuberculosis remains a severe public health problem worldwide .',
  'Tuberculosis ( TB ) remains a serious public health problem worldwide .',
  'Multiple drug resistance ( MDR ) among Mycobacterium tuberculosis poses a serious therapeutic problem .',
  'Despite all improvements in modern medicine , tuberculosis is still a serious public health problem .',
  'Tuberculosis remains a serious public health problem in South Africa .',
  'TB still represents a serious public health problem .',
  '( 5 ) The diagnosis and management of pulmonary tuberculosis in compromised host remain as a serious problem in recent years .',
  'Tuberculosis ( TB ) remains a serious public health problem in South Africa .',
  'Multi-drug resistant tuberculosis ( MDR-TB ) has become a serious concern for proper treatment of patients .',
  'The results show that drug resistance is indeed a serious problem and it may compliment the efforts of the National Tuberculosis Programme to improve strategies to control this disease .',
  'Tuberculosis remains a serious global public health problem .',
  'Tuberculosis is a major threat to global health and its increased incidence in adolescents as well as onset in the elderly presents a serious problem .',
  'Tuberculosis ( TB ) poses a serious public health problem in Angola .',
  'High incidence rates and increasing time trend of tuberculosis in the elderly in Central Serbia is a serious problem , especially among those aged 70 years and over , who might present a target group for active case-finding of the disease .',
  'Introduction : In the context of multidrug-resistant tuberculosis , abandonment of therapy represents a serious public health problem that affects the quality of life of patients , families , and communities .',
  'Tuberculosis continues to be a serious public health problem worldwide .',
  "Tuberculosis of the central nervous system possess a serious clinical and radiological problem , since early treatment of this condition is crucial for the patient 's life , and tuberculous process in the CNS may mimic many other pathologies .",
  'A serious problem remains epidemiological incidence of tuberculosis , which in Poland is almost twice higher than the average for Western Europe .',
  'Tuberculosis remains a serious health problem worldwide .',
  'Tuberculosis is a serious public health problem worldwide .',
  'On the occasion of the commemoration of the 100th anniversary of the discovery of the tubercle bacillus by Robert Koch , in 1982 , it could be stated that in GDR , like in other developed countries , tuberculosis is not any more a serious problem of public health but has changed to a much reduced endemic disease .',
  'Tuberculosis is still a serious public health problem , with 10.8 million new cases and 1.8 million deaths worldwide in 2015 .',
  'In spite of the implementations of several strategies , tuberculosis ( TB ) is overwhelmingly a serious global public health problem causing millions of infections and deaths every year .',
  'Mycobacterium ulcerans causes chronic nectotizing ulcers of the skin and subcutaneous tissue and is a serious health problem in some tropical countries .',
  'Pediatric TB remains a serious health problem , especially among minority children and adolescents .',
  'Multidrug-resistant tuberculosis ( MDR ) caused by strains resistant to both isoniazid and rifampin is now considered a serious sanitary problem worldwide .',
  'Multidrug-resistant tuberculosis ( MDR-TB , defined as resistance to at least both rifampicin and isoniazid ) has become a serious problem in the United Kingdom .',
  'TBE is a preventable disease , which is rapidly becoming a growing public health problem in Europe .',
  'Tuberculosis ( TB ) presents a serious problem in Mozambique .',
  'Tuberculosis represents a serious public health problem and a significant diagnostic and therapeutic challenge worldwide .',
  'On the other hand , tuberculosis , caused by tubercle bacilli which possess the ability to survive in phagosome and grow in cell , poses a serious problem as an intractable disease because the efficacy of drug delivery to the target bacilli is low .',
  'Tuberculosis ( TB ) is a serious public health problem ; however , the cutaneous form remains rare .',
  'Multidrug-resistant ( MDR ) tuberculosis ( TB ) is a serious public health problem .',
  'Multidrug-resistant tuberculosis ( MDR-TB ) is a serious public health problem , but the new drugs bedaquiline ( BDQ ) and delamanid offer hope to improve outcomes and minimise toxicity .',
  'Pulmonary tuberculosis is currently considered a serious health problem worldwide .',
  'Tuberculosis is a serious global health problem .',
  'Tuberculosis ( TB ) remains a serious public health problem aggravated by the emergence of M. tuberculosis ( Mtb ) strains resistant to multiple drugs ( MDR ) .',
  'Tuberculosis is an infectious bacterial disease with a high mortality rate worldwide constituting a serious public health problem .',
  'Tuberculosis , a global health problem and highly prevalent in India , has always been a serious problem with respect to definitive diagnosis .',
  'Multidrug-resistant tuberculosis ( MDR-TB , defined as resistance to at least isoniazid and rifampicin ) has emerged as a serious global public health problem , especially in the former Soviet republics .',
  'Tuberculosis is a serious , worldwide health problem that affects people in many developing countries .',
  'Northern Iran is a critical region in the TB world and multidrug-resistant TB is a serious problem in this region .',
  'Tuberculosis ( TB ) remains a serious human health problem that affects millions of people in the world .',
  'TB-DM comorbidity is expected to pose a serious future health problem due to the alarming rise in global DM incidence .',
  'Tuberculosis : still a serious problem .',
  'Tuberculosis ( TB ) is a serious global health problem , although it is easily preventable and curable .',
  'The high rates of resistance to ethionamide , capreomycin , and kanamycin show the real burden of drug resistance in the region and pose a serious problem for the treatment of patients with multidrug-resistant tuberculosis .',
  'Tuberculosis ( TB ) is one of the oldest diseases of our planet ; today , it still is a serious medicosocial problem in both developing and developed countries .',
  'The selection and soaring spread of Mycobacterium tuberculosis multidrug-resistant ( MDR-TB ) and extensively drug-resistant strains ( XDR-TB ) is a severe public health problem .',
  'Sub-standard deteriorated TB drugs are a serious problem for TB control .',
  'Nosocomial tuberculosis ( TB ) is a serious problem in sub-Saharan Africa due to the absence of protective measures for health care workers ( HCWs ) .',
  'Infection and transmission of multidrug-resistant Mycobacterium tuberculosis ( MDR-Mtb ) and extensively drug-resistant M. tuberculosis ( XDR-Mtb ) is a serious health problem .',
  'Post-Tx TB is a serious problem worldwide , and a high index of suspicion is warranted to ensure early diagnosis and prompt initiation of treatment for TB among renal transplant patients .',
  'Tuberculosis ( TB ) caused by Mycobacterium tuberculosis is a serious global health problem and is responsible for millions of deaths every year .',
  'Tuberculosis will be a serious problem of world health in the year 2000 .',
  'However , the global incidence and prevalence of M. tuberculosis infections is not under control yet , and it has been a serious public health problem .',
  'Tuberculosis ( TB ) is a serious public health concern , and Taiwan has implemented a pay-for-performance ( P4P ) program to incentivize healthcare professionals to provide comprehensive care to TB patients .',
  'Multidrug resistant tuberculosis ( MDR-TB ) is a serious public health problem in Nepal .',
  'TB should be considered in the differential diagnosis of CDI , especially in immunosupressed patients and in countries where this infection is a serious public health problem .',
  'Multidrug-resistant-TB and extensively resistant-TB are a serious problem for control programs .',
  'Resistance and tolerance to antituberculosis ( anti-TB ) drugs , especially the first-line drugs , has become a serious problem in anti-TB therapy .',
  'Drug resistant tuberculosis ( TB ) has lately emerged and it represents a serious public health problem .',
  'Despite the great progress in its diagnosis and treatment , tuberculosis is still a serious health and social problem .',
  'We conclude that TB among farm workers represents a serious public health problem with previously unrecognized risk factors .',
  'Tuberculosis has become a rare disease in the developed countries but it is still a serious problem in the developing countries .',
  'The study demonstrated a severe problem of drug resistance among recently detected TB patients , and two large clusters of genetically similar strains indicated ongoing transmission of drug-resistant TB .',
  'Tuberculosis remains a serious health problem worldwide .',
  'The outbreak of tuberculosis also has been increasing , and has become a serious social problem .',
  'The results of this analysis of drug resistance in MTB reflect the situation in a local hospital and indicate that the morbidity related to TB , especially MDR-TB , is still a serious health problem .',
  'Central nervous system tuberculosis is a serious clinical problem , the treatment of which is sometimes hampered by delayed diagnosis .',
  'Tuberculosis ( TB ) is a serious public health problem worldwide .',
  'Tuberculosis is a widespread infectious disease that still remains a deadly global health problem and a condition that is life-threatening if misdiagnosed .',
  'Drug-resistant Mycobacterium tuberculosis ( TB ) infection represents a serious and growing problem .',
  'Although tuberculosis ( TB ) is a severe health problem worldwide , the current diagnostic methods are far from optimal .',
  'Drug resistance has become a serious public health problem in mycobacterial infectious diseases .',
  'Tuberculosis remains a serious global health problem involving one-third of the world population .',
  'In Cuba , TB is not a serious health problem any more and we are striving to eliminate it in the near future .',
  'Infections caused by drug-resistant Mycobacterium tuberculosis strains represent a serious public health problem in recent years .',
  'Despite the availability of much higher levels of technology in health and medicine , tuberculosis still remains a serious global health problem .',
  'Tuberculosis has re-emerged as a serious health problem throughout the world .',
  'Tuberculosis is still a serious problem in both developing and developed countries .',
  'Rapid and accurate diagnosis of mycobacteria is very important in the prevention and effective treatment of tuberculosis which is still a serious public health problem .',
  'Drug-resistant tuberculosis ( TB ) is a serious emerging problem in many low-resource countries .',
  'Resurgence of strains of multiple-drug resistant tuberculosis is a serious concern .',
  'The low number of cases of tb diagnosed before death represents a serious problem .',
  'Resistance to anti-tuberculosis drugs is a serious public health problem .',
  'HIV-associated TB is a serious public health problem in Myanmar .',
  'Tuberculosis ( TB ) is a serious health concern , particularly in developing countries .',
  'On a world-wide basis , the tuberculosis ( TB ) represents a serious public health problem , existing great differences between developed and developing countries in terms of controlling the disease .',
  'Tuberculosis associated with human immunodeficiency virus ( HIV ) infection continues to represent a serious medical and public health problem .',
  'The co-infection of tuberculosis ( TB ) and human immunodeficiency virus ( HIV ) continue to be a severe problem in the European region .',
  'Tuberculosis ( TB ) is a chronic bacterial disease , which despite the presence of effective drug strategies , still remains a serious health problem worldwide .',
  'Tuberculosis remains a serious public health problem , with nine million cases being reported annually .',
  'Tuberculosis ( TB ) is still a serious public health problem in various countries .',
  'Tuberculosis poses a serious health problem in resource-poor settings such as India .',
  'In Africa , tuberculosis affects over 200 cases per 100,000 persons , and more than 22 million people live with HIV infection ; both diseases are a serious public health problem .',
  'Coinfection with Mycobacterium tuberculosis and human immunodeficiency virus ( HIV ) is a serious problem , particularly in developing countries .',
  'Drug-resistant tuberculosis ( DR-TB ) is a serious problem that impedes the success of the TB control program .',
  'Of the family physicians 21.3 % considered that TB is not a serious problem ; 29 % did not advise BCG vaccination as they considered that BCG vaccination has adverse side effects and limited usefulness .',
  'Tuberculosis has re-emerged as a serious public health concern .',
  "Hepatotoxic effects are a serious problem in patients who are undergoing treatment for tuberculosis , not only because of the morbidity and mortality they directly cause , but also because the liver symptoms can necessitate interruption of therapy or affect a patient 's adherence to it , which can limit the efficacy of the antitubercular regimen .",
  'The situation of tuberculosis ( TB ) is being modified by the human immunodeficiency virus ( HIV ) , which is increasing the occurrence of new cases and the generation of drug resistant strains , affecting not only the people infected with HIV , but also their close contacts and the general population , conforming a serious public health concern .',
  'Tuberculosis continues to be a serious problem of public health causing nearly three million deaths per year all over the world .',
  'The lengthy TB chemotherapeutic regimen , resulting in the emergence of drug resistance strains , poses a serious problem in the cure of the disease .',
  'Treatment default is a serious problem in tuberculosis control because it implies persistence of infection source , increased mortality , increased relapse rates and facilitates the development of resistant strains .',
  'Malnutrition is a serious problem among TB patients in peri-urban areas of Dhaka City .',
  'After years of decline , tuberculosis has reemerged as a serious public health problem worldwide .',
  'Female genital TB is very rare , but each case still remains a serious medical problem .',
  'Tuberculosis ( TB ) control in Georgia follows the World Health Organization-recommended DOTS strategy , and has reached global TB control targets in the treatment of susceptible TB ; however , the management of drug-resistant forms of TB still represents a serious problem .',
  'Tuberculosis still remains a serious health problem in many regions of the world , especially in developing nations .',
  'Nine months of isoniazid therapy is the recommended regimen for treatment of latent tuberculosis infection , but low completion rates are a serious problem .',
  'Tuberculosis is a serious public health concern especially in Africa and Asia .',
  'Tuberculosis continues to be a serious public health problem worldwide .',
  'Despite advances in the diagnostics and treatment of tuberculosis ( TB ) this diseases still poses a serious medical problem .',
  '[ Editorial : Tuberculosis as a serious problem of public health ] .',
  'The selection and spread of Mycobacterium tuberculosis multidrug-resistant ( MDR-TB ) and extensively drug-resistant strains ( XDR-TB ) is a severe public health problem .',
  'Tuberculosis ( TB ) continues to be a leading infectious cause of death worldwide , and it remains a serious public health problem in developing countries .'],
 'tb': ['Health care workers (HCWs) are globally known to have high risk of tuberculosis (TB) infection while risk factors of TB infections among HCWs are still inconclusive',
  'Pulmonary tuberculosis (PTB) is a major health and economic burden',
  'The problem with the emergence of HIV-associated tuberculosis ( which usually occurs in young adults ) is that attention has been diverted away from the fact that , in the developed world , the elderly represent the biggest pool of tubercular disease and therefore the greatest pool of infection within the community .',
  'Importance : A major drawback of current TB chemotherapy is its long duration .',
  'The treatment regimen of HIV-TB coinfection is associated with a major drawback of low therapeutic concentration of drugs in lungs .',
  'Despite being a powerful frontline tuberculosis drug , INH has the potential drawback of inducing its own stable genetic resistance in INH-tolerant persisters .',
  'MDR and XDR tuberculosis are associated with high morbidity and substantial mortality , are a threat to health-care workers , prohibitively expensive to treat , and are therefore a serious public health problem .',
  'In recent years tuberculosis has reemerged as a serious public health problem , raising the possibility that tuberculous eye disease may also become more prevalent .',
  'Co-infection of tuberculosis ( TB ) and HIV is a serious problem in most developing countries and in industrialized countries , co-infection of TB and HIV is seen mainly among migrant population .',
  'Pulmonary tuberculosis ( TB ) remains a serious health problem worldwide .',
  'Tuberculosis ( TB ) remains a serious concern more than two decades on from when the World Health Organization declared it a global health emergency .',
  'Tuberculosis ( TB ) is a serious public health problem worldwide , particularly in developing countries .',
  'Tuberculosis continues to be a serious health problem worldwide .',
  'The rising occurrence of multidrug-resistant tuberculosis ( MDR-TB ) , defined as resistance to at least isoniazid and rifampicin , is a serious worldwide problem .',
  'Tuberculosis is an infectious disease , which is the leading cause of mortality and morbidity and is still a serious health concern .',
  'Intracranial tuberculosis continues to be a serious problem in both the developing and developed world , with significant morbidity and mortality .',
  'Tuberculosis ( TB ) is a severe problem in underdeveloped countries .',
  'Unemployment among TB patients is a serious problem .',
  'Multidrug-resistant tuberculosis continues to be a serious problem , particularly among some countries of eastern Europe .',
  'Multi-drug resistant tuberculosis is a serious clinical problem .',
  'The result of this study indicated that MDR-TB is a serious public health problem in Ethiopia .',
  'Tuberculosis in refugee centres is a serious problem that needs adequate attention .',
  'Tuberculosis ( TB ) is a serious public health problem worldwide .',
  'Tuberculosis ( TB ) is a serious public health problem in many parts of the world .',
  'Tuberculosis ( TB ) continues to be a serious global health problem .',
  'The MDR ( multidrug resistance ) tuberculosis is a serious public health concern .',
  'Tuberculosis ( TB ) is a serious public health problem in developing countries such as Pakistan .',
  'Although mammalian tuberculosis has been nearly controlled in many developed countries , it is still a serious problem in humans and domestic animals including pigs in developing countries .',
  'Multidrug-resistant tuberculosis ( MDR-TB ) is a serious health problem in Eastern European countries , including Latvia .',
  'The prevalence and distribution of drug-resistant TB remains a serious public health problem in Ethiopia .',
  'The incidence of tuberculosis has reduced in Japan , but the slowing down in the rate of decrease of the incidence was pointed , and this tendency is a severe problem in the tuberculosis control .',
  'Emergence of multi-drug resistance tuberculosis has become a serious health problem globally .',
  'The rate of new cases of multidrug resistant tuberculosis ( MDRTB ) continues to increase , and since these infections are very difficult to manage , they constitute a serious health problem .',
  'Tuberculosis ( TB ) is a serious problem for patients undergoing haematopoietic stem cell transplantation ( HSCT ) in TB-endemic areas ; however , data on these patients are limited .',
  'Multidrug-resistant tuberculosis ( MDR-TB ) is a serious problem in the former Soviet Union and may appear during TB treatment .',
  'We conclude that emergence of drug resistant tuberculosis has the potential to be a serious public health problem in Sudan and that strengthened tuberculosis control and improved monitoring of therapy is needed .',
  'Multidrug resistant tuberculosis ( MDR-TB ) still continues to be a serious health problem throughout the world .',
  'Drug-resistant tuberculosis ( TB ) is a serious global problem , and pathogen factors involved in the transmission of isoniazid (INH)-resistant TB have not been fully investigated .',
  'Tuberculosis remains a serious global health problem .',
  'The management of persons exposed to and infected by patients with MDR-TB has become a serious problem in the context of MDR-TB outbreaks .',
  'In recent years , however , tuberculosis has reemerged as a serious public health problem .',
  "In Côte d'Ivoire , multidrug-resistant tuberculosis ( MDR-TB ) is a serious public health problem with a prevalence estimated at 2.5 % in 2006 .",
  'In settings where TB continues being a serious health problem , cost-effectiveness evaluations would privilege TST under certain conditions : supply of quality-assured PPD reagent , standardized criteria for TST application , reading and interpretation , and regular availability in health centers countrywide .',
  'Hence , tuberculosis is once again a serious global problem not only in the developing countries of Africa or South East Asia , but also in highly-developed communities .',
  'The developing world is facing a serious problem of tuberculosis ( TB ) since ages .',
  'Central nervous system ( CNS ) tuberculosis is a serious clinical problem , the treatment of which is sometimes hampered by delayed diagnosis .',
  'Multi-drug resistant tuberculosis ( MDR-TB ) is emerging as a serious global health problem , which has been elevated through co-infection involving HIV and MDR-Mtb .',
  "The study concludes that ' system ' delay is a serious problem , which is influenced by the financing mechanisms for both TB control and general health services as well as poverty and disadvantage amongst patients .",
  'Even more alarming is the increasing incidence of multidrug-resistant tuberculosis which presents a serious public health problem , particularly for HIV-infected patients .',
  'Extensively drug-resistant ( XDR ) tuberculosis ( TB ) represents a serious and growing problem in both endemic and non-endemic countries .',
  'Multidrug-resistant tuberculosis in children is a severe form of tuberculosis , which remains a major health problem especially in developing countries .',
  'Tuberculosis ( TB ) is still a serious public health problem , continuing to be an important threat for confined populations .',
  'Recently , tuberculosis re-emerged as a serious public health problem , in industrialized countries , while remaining it remains a major cause of mortality and morbidity in third world countries .',
  'Although Galicia has a high incidence of TB ( 49.4 cases per 100 000 population in 2001 ) , the resistance levels detected by the study do not currently pose a serious problem for the region .',
  'According to the official domestic statistics pulmonary tuberculosis continues to be a serious problem for the Russian Federation .',
  'Multidrug-resistant tuberculosis ( MDRTB ) is a serious world health problem that limits public actions to control tuberculosis , because the most used anti-tuberculosis first-line drugs fail to stop mycobacterium spread .',
  'Tuberculosis continues to be a serious public health problem worldwide .',
  'Tuberculosis has re-emerged as a serious public health problem in recent years .',
  'Despite the use of bacille Calmette-Guérin ( BCG ) for almost a century , pulmonary tuberculosis ( TB ) continues to be a serious global health concern .',
  '< sec > < title > BACKGROUND</title > Tuberculosis ( TB ) remains a serious health problem worldwide .',
  'Tuberculosis is a serious problem of public health .',
  'Tuberculosis ( TB ) remains a serious public health problem despite the great scientific advances in the recent decades .',
  'At a time when reduction in Federal support for tuberculosis control is being considered , it is important to realize that the disease remains a serious medical problem and financial burden in the United States .',
  'Drug resistant tuberculosis is a serious problem in control of tuberculosis .',
  'Tuberculosis ( TB ) remains a serious global public health problem that results in up to 2 million deaths each year .',
  'Tuberculosis remains a serious health problem worldwide , particularly affecting the poorest in both high-income and developing countries .',
  'The high prevalence of diabetes mellitus ( DM ) among multidrug resistant tuberculosis ( MDR-TB ) patients is a serious cause for concern .',
  'The emergence of drug resistant tuberculosis poses a serious concern globally and researchers are in rigorous search for new drugs to fight against these dreadful bacteria .',
  'Tuberculosis ( TB ) is a serious world-wide health problem , causing millions of deaths every year .',
  'Tuberculosis ( TB ) is a serious health problem in Papua New Guinea ( PNG ) with an estimated 30000 new cases and 3800 deaths each year .',
  "Tuberculosis ( TB ) presents a serious health problem with approximately one-third of the world 's population infected with",
  'The pandemic spread of tuberculosis ( TB ) and human immunodeficiency virus ( HIV ) represents a serious world problem .',
  'Tuberculosis ( TB ) remains a serious public health problem in spite of DOTS programme recommended by WHO .',
  'Extensively drug-resistant tuberculosis ( XDR-TB ) is a serious worldwide problem .',
  'Tuberculosis remains a severe public health problem , and is a major cause of infant disease in North Lebanon .',
  'This case reminds us that correct diagnosis of tuberculosis remains a serious problem despite the long experience and the development of diagnostics and treatment methods .',
  'Many researchers have done a lot of research and achieved remarkable results , but TB is still a severe problem for human beings .',
  'Tuberculosis ( TB ) , a dreadful disease known to mankind continues to be a problem in a developing country like India .',
  "Nigeria has the world 's fourth largest tuberculosis burden , and multidrug resistant tuberculosis ( MDR-TB ) represents a serious public health problem .",
  'Tuberculosis continues to be a serious problem in public health even thought eh causative bacillus was discovered over 100 years ago .',
  'Tuberculosis is a serious health problem in India , but because of inadequate facilities for diagnosis in many parts of the country clinical data are incomplete .',
  'The aim of this study was to evaluate the percentage and characteristics of extrapulmonary tuberculosis ( EPTB ) cases in a Turkish industrial city , Kocaeli ( population : 1,203,335 ) and to illustrate its extent as a serious health problem for this city and country .',
  'Worldwide , tuberculosis ( TB ) is still a serious and significant health concern , more so with the emergence of multidrug-resistant-TB .',
  "Tuberculosi remains a serious public health problem in the Americas , and it has not declined as rapidly or as much as experts projected it would in the 1940 's .",
  'The basic epidemiological parameters ( prevalence , incidence , mortality due to tuberculosis ) and inadequate efficiency of treatment of patients suggest that tuberculosis remains to be a serious problem in the North-West of Russia .',
  'Extrapulmonary tuberculosis : a debilitating and often neglected public health problem .',
  'Tuberculosis ( TB - Mycobacterium tuberculosis ) is an ancient infectious disease that has appeared once again as a serious worldwide health problem and now comprises the second leading cause of death resulting from a single infection .',
  'Poor performance of Mantoux test is a serious concern and requires the attention of TB programme managers and other relevant authorities .',
  'It has a severe tuberculosis ( TB ) problem , with a new tuberculosis case notification rate , all forms , of about 150 per 100000 population and a tuberculosis programme , established in the early 1980s , achieving cure rates of only 40 - 50 % in the last decade .',
  'Tuberculosis may be as old as mankind and continues to be a serious medical problem today .',
  'Tuberculosis historically was a major impetus for the development of thoracic surgery , and it remains a serious health problem of global proportion .',
  'Peritoneal tuberculosis ( PTB ) , although rarer than its pulmonary counterpart , is a serious health concern in regions of the world with high tuberculosis prevalence .',
  'The increasing number of sputum smear- and culture-negative TB patients is a serious concern because misdiagnosis and delayed treatment can lead to increased morbidity and mortality and increased infectious transmission .',
  "The incidence of tuberculosis has decreased in Japan , and , many doctors did not show concern on , thus , a doctor 's delay is a serious problem in Japan .",
  'Multidrug-resistant ( MDR ) tuberculosis , defined as tuberculosis resistant to the two first-line drugs isoniazid and rifampin , poses a serious problem for global tuberculosis control strategies .',
  'Tuberculosis currently remains a serious medical problem , therefore increased attention is being paid to this disease .',
  'To this end , reactivation of latent tuberculosis infection represents a serious concern of anti-TNFalpha antibody therapy .',
  'Tuberculosis ( TB ) remains a serious health problem responsible to cause millions of deaths annually .',
  'TB is a serious global public health problem .',
  'Multidrug resistant tuberculosis ( MDR-TB ) remains a serious public health problem with poor treatment outcomes .',
  'Patient delay appears to be a serious problem in this rural area with a high prevalence of tuberculosis .',
  'Bone and joint tuberculosis is a serious medical problem ; tuberculosis of sternoclavicular joint is rare .',
  'Tuberculosis involvement of the central nervous system continues to represent a serious problem , particularly in developing countries .',
  'Tuberculosis ( TB ) is still a severe public health problem ; the current diagnostic tests have limitations that delay treatment onset .',
  'Tuberculosis , caused by Mycobacterium tuberculosis , is a serious infectious disease and remains a global health problem .',
  'Tuberculosis ( TB ) continues to be a serious public health problem and establishing a definitive diagnosis among children is extremely challenging .',
  'Tuberculosis remains a serious social and public health problem , affecting millions of people annually .',
  'Tuberculosis ( TB ) is a serious re-emergent public health problem in the UK .',
  'Unsuccessful TB treatment outcome is a serious public health concern .',
  'Tuberculosis ( TB ) is an infectious , devastating and contagious disease , which infects third of the global population worldwide with high rates of incidence in the developing countries , where   the health care providers face   a serious problem and a real challenge during their clinical practice for controlling and preventing the transmission of this illness .',
  'Although TBE is a serious problem in Latvia , the knowledge concerning TBE virus ( TBEV ) strains circulating in the country is most limited .',
  '11(6 ) , 435 - 444 (2011).Tuberculosis ( TB ) is a serious public health problem in the UK , and detection and prophylactic treatment of latent infection offers improved control .',
  'MDR-TB are defined as strains which are resistant to at least isoniazid ( INH ) and rifampicin , the two most potent TB drugs , and their increasing incidence is a serious concern .',
  'The drug susceptibility profile developed in the present study indicates that drug-resistant tuberculosis is emerging as a serious public health concern in Sahariya tribe .',
  'Tuberculosis ( TB ) has reappeared as a serious public health problem .',
  'Multi-drug resistant ( MDR ) Mycobacterium tuberculosis is still a serious public health problem all over the world .',
  'The fact that a prior BCG scar is not associated with a positive response to the TT indicates the need to re-open discussion of the guidelines which exist in many poor countries where tuberculosis is still a serious public health problem .',
  'Tuberculosis ( TB ) has emerged as a serious public health problem in the country of Georgia .',
  'It is essential to highlight this alarming presentation in a child , as the presence of tuberculosis has re-emerged as a serious public health problem especially in developing countries .',
  'Tuberculosis ( TB ) has become a rare disease in the developed countries but it is still a serious problem in developing countries .',
  'Tuberculosis is still one of the most common infectious diseases along with HIV and malaria and therefore represents a serious problem in the health sector .',
  'There is existing still a serious problem of chronic tuberculosis .',
  'Tuberculosis ( TB ) is a serious public health problem in many regions of the world , especially in the poorest areas .',
  'Drug resistance is a serious problem in the treatment of tuberculosis and a threat to successful tuberculosis control programmes .',
  'Tuberculosis is a serious public health problem worldwide .',
  'However , death among younger patients with TB is also a serious concern , and although several socio-economic factors have been suggested in the past , these studies have varied in methods and results .',
  'This review indicated that MDR-TB in Ethiopia is a serious public health problem that needs to be addressed urgently .',
  'Tuberculosis ( TB ) has remained a devastating global public health problem .',
  'TBE is a serious problem in Latvia with up to a 1,000 patients confirmed serologically annually 1994 - 1995 .',
  'Drug-resistant tuberculosis is a serious problem throughout the world .',
  'It may be cautioned that , among infectious diseases , tuberculosis is still a serious health problem today and HIV infection has become a threatening health issue although the number of AIDS patients reported was still about 1,000 for the whole country in 1995 .',
  'Tuberculosis ( TB ) is a serious worldwide public health problem , and drug resistance , particularly multidrug resistance ( MDR ) , is a critical factor involved in TB control .',
  'Drug resistant tuberculosis y a serious problem in Chiapas that requires urgent attention if future control of the disease is to be maintained .',
  "Tuberculosis remains the world 's leading cause of death from an infectious agent , and is a serious health problem in Papua New Guinea ( PNG ) with an estimated 36,000 new cases each year .",
  'Having a history as old as the history of humanity , Tuberculosis ( TB ) is a serious disease and it is regarded as an important a public health problem not only for its medical aspect but also for its social and ethical aspects .',
  'XDR-TB has become a serious problem for the health administrations in this region .',
  'Reactivation tuberculosis ( TB ) is a serious problem in immunocompromised individuals , especially those with human immunodeficiency virus ( HIV ) coinfection .',
  'In conclusion , posttransplantation TB is a serious problem worldwide , and a high index of suspicion is warranted to ensure early diagnosis and prompt initiation of treatment for TB among SOT patients .',
  'Tuberculosis poses a global public health threat , and individuals who fail to comply with treatment risk developing drug-resistant strains , which are a serious public health concern .',
  "One third of the world 's population is infected with TB , and in conjunction with HIV represents a serious problem that urgently needs addressing .",
  'TB remains , however , a serious health problem in the CR .',
  'Tuberculosis continues to be a devastating public health problem .',
  'The emergence of resistance in tuberculosis has become a serious problem for the control of this disease .',
  'Tuberculosis is a serious global health problem caused by the bacterium Mycobacterium tuberculosis .',
  'More re-treatment TB patients are notified in India than any other country in the world , and default among this group is a serious public health problem .',
  'The interaction between HIV and M. tuberculosis infection poses a serious health problem which will result in a major increase in disease , death and health care service needs in many countries .',
  'Tuberculosis and multidrug-resistant tuberculosis is a serious public health problem in Russia .',
  'Despite decreasing numbers of cases in the United States since 1992 , TB remains a serious public health problem among certain patient populations and is highly prevalent in many urban areas .',
  'Tuberculosis ( TB ) is a serious public health problem .',
  'Tuberculosis remains a serious human public health concern .',
  'Tuberculosis is a serious public health problem worldwide , particularly in developing countries .',
  'Tuberculosis ( TB ) remains a serious public-health problem worldwide .',
  'The high rate of MDR-TB illustrates a serious problem .',
  'Tuberculosis remains a severe public health problem worldwide .',
  'Tuberculosis ( TB ) remains a serious public health problem worldwide .',
  'Despite all improvements in modern medicine , tuberculosis is still a serious public health problem .',
  'Tuberculosis remains a serious public health problem in South Africa .',
  'TB still represents a serious public health problem .',
  '( 5 ) The diagnosis and management of pulmonary tuberculosis in compromised host remain as a serious problem in recent years .',
  'Tuberculosis ( TB ) remains a serious public health problem in South Africa .',
  'Multi-drug resistant tuberculosis ( MDR-TB ) has become a serious concern for proper treatment of patients .',
  'The results show that drug resistance is indeed a serious problem and it may compliment the efforts of the National Tuberculosis Programme to improve strategies to control this disease .',
  'Tuberculosis remains a serious global public health problem .',
  'Tuberculosis is a major threat to global health and its increased incidence in adolescents as well as onset in the elderly presents a serious problem .',
  'Tuberculosis ( TB ) poses a serious public health problem in Angola .',
  'High incidence rates and increasing time trend of tuberculosis in the elderly in Central Serbia is a serious problem , especially among those aged 70 years and over , who might present a target group for active case-finding of the disease .',
  'Introduction : In the context of multidrug-resistant tuberculosis , abandonment of therapy represents a serious public health problem that affects the quality of life of patients , families , and communities .',
  'Tuberculosis continues to be a serious public health problem worldwide .',
  "Tuberculosis of the central nervous system possess a serious clinical and radiological problem , since early treatment of this condition is crucial for the patient 's life , and tuberculous process in the CNS may mimic many other pathologies .",
  'A serious problem remains epidemiological incidence of tuberculosis , which in Poland is almost twice higher than the average for Western Europe .',
  'Tuberculosis remains a serious health problem worldwide .',
  'Tuberculosis is a serious public health problem worldwide .',
  'On the occasion of the commemoration of the 100th anniversary of the discovery of the tubercle bacillus by Robert Koch , in 1982 , it could be stated that in GDR , like in other developed countries , tuberculosis is not any more a serious problem of public health but has changed to a much reduced endemic disease .',
  'Tuberculosis is still a serious public health problem , with 10.8 million new cases and 1.8 million deaths worldwide in 2015 .',
  'In spite of the implementations of several strategies , tuberculosis ( TB ) is overwhelmingly a serious global public health problem causing millions of infections and deaths every year .',
  'Pediatric TB remains a serious health problem , especially among minority children and adolescents .',
  'Multidrug-resistant tuberculosis ( MDR ) caused by strains resistant to both isoniazid and rifampin is now considered a serious sanitary problem worldwide .',
  'Multidrug-resistant tuberculosis ( MDR-TB , defined as resistance to at least both rifampicin and isoniazid ) has become a serious problem in the United Kingdom .',
  'TBE is a preventable disease , which is rapidly becoming a growing public health problem in Europe .',
  'Tuberculosis ( TB ) presents a serious problem in Mozambique .',
  'Tuberculosis represents a serious public health problem and a significant diagnostic and therapeutic challenge worldwide .',
  'On the other hand , tuberculosis , caused by tubercle bacilli which possess the ability to survive in phagosome and grow in cell , poses a serious problem as an intractable disease because the efficacy of drug delivery to the target bacilli is low .',
  'Tuberculosis ( TB ) is a serious public health problem ; however , the cutaneous form remains rare .',
  'Multidrug-resistant ( MDR ) tuberculosis ( TB ) is a serious public health problem .',
  'Multidrug-resistant tuberculosis ( MDR-TB ) is a serious public health problem , but the new drugs bedaquiline ( BDQ ) and delamanid offer hope to improve outcomes and minimise toxicity .',
  'Pulmonary tuberculosis is currently considered a serious health problem worldwide .',
  'Tuberculosis is a serious global health problem .',
  'Tuberculosis ( TB ) remains a serious public health problem aggravated by the emergence of M. tuberculosis ( Mtb ) strains resistant to multiple drugs ( MDR ) .',
  'Tuberculosis is an infectious bacterial disease with a high mortality rate worldwide constituting a serious public health problem .',
  'Tuberculosis , a global health problem and highly prevalent in India , has always been a serious problem with respect to definitive diagnosis .',
  'Multidrug-resistant tuberculosis ( MDR-TB , defined as resistance to at least isoniazid and rifampicin ) has emerged as a serious global public health problem , especially in the former Soviet republics .',
  'Tuberculosis is a serious , worldwide health problem that affects people in many developing countries .',
  'Northern Iran is a critical region in the TB world and multidrug-resistant TB is a serious problem in this region .',
  'Tuberculosis ( TB ) remains a serious human health problem that affects millions of people in the world .',
  'TB-DM comorbidity is expected to pose a serious future health problem due to the alarming rise in global DM incidence .',
  'Tuberculosis : still a serious problem .',
  'Tuberculosis ( TB ) is a serious global health problem , although it is easily preventable and curable .',
  'The high rates of resistance to ethionamide , capreomycin , and kanamycin show the real burden of drug resistance in the region and pose a serious problem for the treatment of patients with multidrug-resistant tuberculosis .',
  'Tuberculosis ( TB ) is one of the oldest diseases of our planet ; today , it still is a serious medicosocial problem in both developing and developed countries .',
  'Sub-standard deteriorated TB drugs are a serious problem for TB control .',
  'Nosocomial tuberculosis ( TB ) is a serious problem in sub-Saharan Africa due to the absence of protective measures for health care workers ( HCWs ) .',
  'Post-Tx TB is a serious problem worldwide , and a high index of suspicion is warranted to ensure early diagnosis and prompt initiation of treatment for TB among renal transplant patients .',
  'Tuberculosis ( TB ) caused by Mycobacterium tuberculosis is a serious global health problem and is responsible for millions of deaths every year .',
  'Tuberculosis will be a serious problem of world health in the year 2000 .',
  'However , the global incidence and prevalence of M. tuberculosis infections is not under control yet , and it has been a serious public health problem .',
  'Tuberculosis ( TB ) is a serious public health concern , and Taiwan has implemented a pay-for-performance ( P4P ) program to incentivize healthcare professionals to provide comprehensive care to TB patients .',
  'Multidrug resistant tuberculosis ( MDR-TB ) is a serious public health problem in Nepal .',
  'TB should be considered in the differential diagnosis of CDI , especially in immunosupressed patients and in countries where this infection is a serious public health problem .',
  'Multidrug-resistant-TB and extensively resistant-TB are a serious problem for control programs .',
  'Resistance and tolerance to antituberculosis ( anti-TB ) drugs , especially the first-line drugs , has become a serious problem in anti-TB therapy .',
  'Drug resistant tuberculosis ( TB ) has lately emerged and it represents a serious public health problem .',
  'Despite the great progress in its diagnosis and treatment , tuberculosis is still a serious health and social problem .',
  'We conclude that TB among farm workers represents a serious public health problem with previously unrecognized risk factors .',
  'Tuberculosis has become a rare disease in the developed countries but it is still a serious problem in the developing countries .',
  'The study demonstrated a severe problem of drug resistance among recently detected TB patients , and two large clusters of genetically similar strains indicated ongoing transmission of drug-resistant TB .',
  'Tuberculosis remains a serious health problem worldwide .',
  'The outbreak of tuberculosis also has been increasing , and has become a serious social problem .',
  'The results of this analysis of drug resistance in MTB reflect the situation in a local hospital and indicate that the morbidity related to TB , especially MDR-TB , is still a serious health problem .',
  'Central nervous system tuberculosis is a serious clinical problem , the treatment of which is sometimes hampered by delayed diagnosis .',
  'Tuberculosis ( TB ) is a serious public health problem worldwide .',
  'Tuberculosis is a widespread infectious disease that still remains a deadly global health problem and a condition that is life-threatening if misdiagnosed .',
  'Although tuberculosis ( TB ) is a severe health problem worldwide , the current diagnostic methods are far from optimal .',
  'Tuberculosis remains a serious global health problem involving one-third of the world population .',
  'In Cuba , TB is not a serious health problem any more and we are striving to eliminate it in the near future .',
  'Despite the availability of much higher levels of technology in health and medicine , tuberculosis still remains a serious global health problem .',
  'Tuberculosis has re-emerged as a serious health problem throughout the world .',
  'Tuberculosis is still a serious problem in both developing and developed countries .',
  'Drug-resistant tuberculosis ( TB ) is a serious emerging problem in many low-resource countries .',
  'Resurgence of strains of multiple-drug resistant tuberculosis is a serious concern .',
  'The low number of cases of tb diagnosed before death represents a serious problem .',
  'Resistance to anti-tuberculosis drugs is a serious public health problem .',
  'HIV-associated TB is a serious public health problem in Myanmar .',
  'Tuberculosis ( TB ) is a serious health concern , particularly in developing countries .',
  'On a world-wide basis , the tuberculosis ( TB ) represents a serious public health problem , existing great differences between developed and developing countries in terms of controlling the disease .',
  'Tuberculosis associated with human immunodeficiency virus ( HIV ) infection continues to represent a serious medical and public health problem .',
  'The co-infection of tuberculosis ( TB ) and human immunodeficiency virus ( HIV ) continue to be a severe problem in the European region .',
  'Tuberculosis ( TB ) is a chronic bacterial disease , which despite the presence of effective drug strategies , still remains a serious health problem worldwide .',
  'Tuberculosis remains a serious public health problem , with nine million cases being reported annually .',
  'Tuberculosis ( TB ) is still a serious public health problem in various countries .',
  'Tuberculosis poses a serious health problem in resource-poor settings such as India .',
  'In Africa , tuberculosis affects over 200 cases per 100,000 persons , and more than 22 million people live with HIV infection ; both diseases are a serious public health problem .',
  'Coinfection with Mycobacterium tuberculosis and human immunodeficiency virus ( HIV ) is a serious problem , particularly in developing countries .',
  'Drug-resistant tuberculosis ( DR-TB ) is a serious problem that impedes the success of the TB control program .',
  'Of the family physicians 21.3 % considered that TB is not a serious problem ; 29 % did not advise BCG vaccination as they considered that BCG vaccination has adverse side effects and limited usefulness .',
  'Tuberculosis has re-emerged as a serious public health concern .',
  "Hepatotoxic effects are a serious problem in patients who are undergoing treatment for tuberculosis , not only because of the morbidity and mortality they directly cause , but also because the liver symptoms can necessitate interruption of therapy or affect a patient 's adherence to it , which can limit the efficacy of the antitubercular regimen .",
  'The situation of tuberculosis ( TB ) is being modified by the human immunodeficiency virus ( HIV ) , which is increasing the occurrence of new cases and the generation of drug resistant strains , affecting not only the people infected with HIV , but also their close contacts and the general population , conforming a serious public health concern .',
  'Tuberculosis continues to be a serious problem of public health causing nearly three million deaths per year all over the world .',
  'The lengthy TB chemotherapeutic regimen , resulting in the emergence of drug resistance strains , poses a serious problem in the cure of the disease .',
  'Treatment default is a serious problem in tuberculosis control because it implies persistence of infection source , increased mortality , increased relapse rates and facilitates the development of resistant strains .',
  'Malnutrition is a serious problem among TB patients in peri-urban areas of Dhaka City .',
  'After years of decline , tuberculosis has reemerged as a serious public health problem worldwide .',
  'Female genital TB is very rare , but each case still remains a serious medical problem .',
  'Tuberculosis ( TB ) control in Georgia follows the World Health Organization-recommended DOTS strategy , and has reached global TB control targets in the treatment of susceptible TB ; however , the management of drug-resistant forms of TB still represents a serious problem .',
  'Tuberculosis still remains a serious health problem in many regions of the world , especially in developing nations .',
  'Nine months of isoniazid therapy is the recommended regimen for treatment of latent tuberculosis infection , but low completion rates are a serious problem .',
  'Tuberculosis is a serious public health concern especially in Africa and Asia .',
  'Tuberculosis continues to be a serious public health problem worldwide .',
  'Despite advances in the diagnostics and treatment of tuberculosis ( TB ) this diseases still poses a serious medical problem .',
  '[ Editorial : Tuberculosis as a serious problem of public health ] .',
  'Tuberculosis ( TB ) continues to be a leading infectious cause of death worldwide , and it remains a serious public health problem in developing countries .'],
 'malnutrition': ["Even though the nutritional assessment of chronically ill patients has a significant effect on outcomes, nurses' time constraints in clinical encounters may make the process impractical",
  'Disease-related malnutrition is a challenge among hospitalized patients',
  "The problem with poor ; QoL , nutritional care and academic performance ( AP ) of the OVC is that it sets the foundation for their adults ' life .",
  'The problem with any attempt to feed patients in multiple organ failure is that , because of an ongoing inflammatory process , the conventional techniques of supplying energy and protein do not maintain lean tissue mass .',
  'Malnutrition remains a serious public health problem , and thus , the development of novel treatment methods is highly essential .',
  'Childhood malnutrition is still a serious worldwide public health problem and its consequences are particularly severe when present during early life .',
  'Malnutrition remains a severe problem in the recovery of critically ill patients and leads to increased in-hospital morbidity and in-hospital stay .',
  'Malnutrition is a serious problem , and malabsorption of nutrients is believed to be partially responsible for its prevalence .',
  'Under-nutrition in older people : a serious and growing global problem !',
  'Malnutrition is a serious problem to frail elderly .',
  'Malnutrition is a serious problem among children in developing countries .',
  'Malnutrition is a severe problem among elderly residents living in long-term care facilities .',
  '[ Malnutrition in the hospital - a preventable problem ] .',
  'Though Ethiopia has implemented different nutritional interventions , childhood stunting on which literature is limited continues as a severe public health problem .',
  'Undernutrition is a serious global problem that contributes to increased child morbidity and mortality , impaired neurocognitive development , and decreased educational and economic attainment .',
  'However , the prevalence of undernutrition remains a serious problem .',
  'Malnutrition is a serious health concern for frail elderly people .',
  'Malnutrition is a serious public health problem in Cameroon .',
  'Under-nutrition in older individuals is a serious and growing problem , as a result , amongst other factors , of decreased intake .',
  'This study indicates that undernutrition is a serious problem among rural Malawians aged 45 - 75 years .',
  'Malnutrition is a serious public health problem that affects approximately one third of all children .',
  'Malnutrition is a serious concern in hospitals and is known to be associated with increased complications for patients , increased hospital costs and length of stay .',
  'Inadequate daily intake of energy and nutrients of most of the children , in combination with parasitic infections , still common in rural northeast Thailand , was shown to result in a serious public health problem .',
  'A low prevalence of children with a weight-for-age Z-score below -2 was found , indicating that at the time of the survey protein-energy malnutrition was not a serious problem for this age group .',
  'Severe acute malnutrition ( SAM ) remains a serious public health concern in low- and middle-income countries .',
  'Hospitalization of elderly people with dehydration is a serious and costly medical problem .',
  'Deficiency/disability in children is still a serious medical , social and human problem .',
  'The results indicate that malnutrition is a serious public health problem in the studied regions .',
  'Since malnutrition in the elderly is a serious problem , it should be treated promptly .',
  'Child undernutrition is a serious public health problem in many low- and middle-income countries .',
  'Malnutrition remains a serious concern in Rwanda , particularly among children under-5 years .',
  'Undernutrition presenting as malnutrition is a serious health concern for frail elderly people with many health problems .',
  'Introduction : Child malnutrition remains a serious public health problem in Honduras , with a national prevalence according to the World Health',
  'Child wasting is a severe public health problem in the predominantly rural population of Ethiopia : A community based cross-sectional study .',
  'The severity of hunger in mountain and hill districts of Mid- and Far-Western Development Regions is a serious concern .',
  'Malnutrition constitutes a serious and challenging problem in elderly care .',
  'Malnutrition remains a serious health problem in Cambodia with over 10 % of children less than five years of age suffering from acute malnutrition .',
  'In Ethiopia , child undernutrition continues to be a serious public health problem .',
  'Undernutrition in hospitalized older adults is increasingly being recognized as a serious problem with implications for both patient care and outcomes and health service utilization and costs .',
  'However malnutrition in poor areas is still a serious problem .',
  'However , malnutrition is a serious health problem among the elderly , particularly the elderly living in rural areas in many developing countries .',
  'Childhood malnutrition and growth faltering is a serious concern in Nepal .',
  'Malnutrition in the elderly is a serious problem , prevalent in both hospitals and care homes .',
  'Malnutrition among the elderly has become a serious problem as their population increases in Japan .',
  'Malnutrition continues to be a serious problem in older adults .',
  'Enteral nutrition ( EN ) misconnections have been identified as a serious and potential deadly problem .',
  'Malnutrition in hospitalized patients is a serious problem and is associated with a number of adverse outcomes .',
  'Malnutrition is a serious problem in the elderly while understanding flavour perception could be a tool for controlling appetite or food choices .',
  'These results show that malnutrition is still a serious public health problem in Kenya and requires urgent attention .',
  'Malnutrition among children is a serious public health problem in the aftermath of any natural disaster .',
  'Malnutrition is a serious problem in older adults , particularly for those at risk of hospital readmission .',
  'Food insecurity remains highly prevalent in developing countries and over the past two decades it has increasingly been recognized as a serious public health problem , including in Ethiopia .',
  'A body of evidences showed that adolescent undernutrition is a serious public health problem in developing countries including Ethiopia .',
  'Malnutrition is a severe problem of public health over all the world , particularly in Latin America .',
  'The results of this study confirm that a complete patient assessment must include evaluating patient nutritional status and that nutritional disorders are a serious problem among the elderly , especially those with venous ulcers .',
  'Malnutrition in institutionalized older people is a serious problem having negative impact on patient outcomes .',
  'Although globally the numbers of children diagnosed with failure to thrive ( FTT ) have decreased , FTT is still a serious pediatric problem .',
  'Maternal undernutrition persists as a serious problem in Ethiopia .',
  'A 54-year-old profoundly mentally retarded female patient with phenylketonuria and a severe behaviour problem was treated with a restricted protein and high energy diet .',
  'Poor nutritional status of women has been a serious problem in Ethiopia .',
  'Malnutrition is a serious public health problem , particularly in developing countries , linked to a substantial increase in the risk of mortality and morbidity .',
  'Overnutrition as well as undernutrition is a serious problem in hospitalized patients , especially in infants .',
  'Malnutrition is a serious and relatively common problem among hospitalized patients ; moreover , it is known that a good hydration state contributes to health and wellbeing .',
  'Mortality of children with severe acute malnutrition ( SAM ) is a devastating problem in Ethiopia .',
  'Protein-energy malnutrition ( PEM ) is a serious health problem among young children in Bangladesh .',
  'The burden of food insecurity and malnutrition is a severe problem experienced by many poor households and children under the age of five are at high risk .',
  'Nutritional deficiencies in children represents a serious public health problem in Bom Jesus , Angola .',
  'Malnutrition is a serious public health problem . The humanitarian community needs to adopt alternative strategies to improve food security and the nutrition status in Yemen .',
  'Malnutrition is a serious public health problem that has been linked to increase risk of morbidity and mortality in slums of Dhaka city and where the prevalence of malnutrition is very high .',
  'Malnutrition and bacterial gastrointestinal and respiratory infections represent a serious public health problem .',
  'It has been recognized that malnutrition in hospital is a serious problem that may go undetected .',
  'Undernutrition is a serious health problem and highly prevalent in developing countries .',
  'Micronutrient malnutrition is a serious public health problem in developing countries , including Sri Lanka .',
  'Despite the failures of numerous diagnostic methods-even the definition of malnutrition defied consensus-health authorities remained convinced that malnutrition was a serious and widespread problem .',
  'Childhood undernutrition is a serious public health problem in South Africa .',
  'Rehabilitating a child with a severe feeding problem .',
  'The ENAL 96 shows that malnutrition is still a severe national problem which has not improved in the last 22 years .',
  'Childhood overnutrition is a serious public health problem , with consequences that extend into adulthood .',
  'Protein-energy malnutrition ( PEM ) is a serious nutritional problem that causes immune dysfunction in elderly people .',
  'Malnutrition in children under 5 years of age ( U5s ) is a serious public health problem in low- and middle-income countries including Bangladesh .',
  'The improper relations between Fe and energy content in food rations of women at the reproductive age were found to deserve a serious concern .',
  'However , published estimates suggest that malnutrition continues to be a serious public health problem .',
  'The study concludes that maternal malnutrition is a serious problem in the study area and that there are contextual risk factors that could be addressed to partially tackle the problem .',
  'Insufficient intake of fresh fruits , vegetables , and dairy products among children is a serious nutrition-related concern .',
  'Childhood malnutrition is a serious public health problem in Yemen .',
  'Malnutrition among the indigenous early childhood population is still currently a serious public health problem , and given that no specific studies affording the possibility of knowing the nutritional condition of this population , the question was posed of identifying the prevalence of malnutrition among the indigenous population of Mexico by means of the 1999 National Nutrition Survey .',
  'The double burden of malnutrition also affects the poor , which is a serious problem in Asia , as it has the largest number of poor subsisting on less than $ 1/day .'],
 'elderly': ["Even though the nutritional assessment of chronically ill patients has a significant effect on outcomes, nurses' time constraints in clinical encounters may make the process impractical",
  'Disease-related malnutrition is a challenge among hospitalized patients',
  'The problem with any attempt to feed patients in multiple organ failure is that , because of an ongoing inflammatory process , the conventional techniques of supplying energy and protein do not maintain lean tissue mass .',
  'Malnutrition remains a severe problem in the recovery of critically ill patients and leads to increased in-hospital morbidity and in-hospital stay .',
  'Under-nutrition in older people : a serious and growing global problem !',
  'Malnutrition is a serious problem to frail elderly .',
  'Malnutrition is a severe problem among elderly residents living in long-term care facilities .',
  '[ Malnutrition in the hospital - a preventable problem ] .',
  'Malnutrition is a serious health concern for frail elderly people .',
  'Under-nutrition in older individuals is a serious and growing problem , as a result , amongst other factors , of decreased intake .',
  'Malnutrition is a serious concern in hospitals and is known to be associated with increased complications for patients , increased hospital costs and length of stay .',
  'Hospitalization of elderly people with dehydration is a serious and costly medical problem .',
  'Since malnutrition in the elderly is a serious problem , it should be treated promptly .',
  'Undernutrition presenting as malnutrition is a serious health concern for frail elderly people with many health problems .',
  'Malnutrition constitutes a serious and challenging problem in elderly care .',
  'Undernutrition in hospitalized older adults is increasingly being recognized as a serious problem with implications for both patient care and outcomes and health service utilization and costs .',
  'However , malnutrition is a serious health problem among the elderly , particularly the elderly living in rural areas in many developing countries .',
  'Malnutrition in the elderly is a serious problem , prevalent in both hospitals and care homes .',
  'Malnutrition among the elderly has become a serious problem as their population increases in Japan .',
  'Malnutrition continues to be a serious problem in older adults .',
  'Enteral nutrition ( EN ) misconnections have been identified as a serious and potential deadly problem .',
  'Malnutrition in hospitalized patients is a serious problem and is associated with a number of adverse outcomes .',
  'Malnutrition is a serious problem in the elderly while understanding flavour perception could be a tool for controlling appetite or food choices .',
  'Malnutrition is a serious problem in older adults , particularly for those at risk of hospital readmission .',
  'The results of this study confirm that a complete patient assessment must include evaluating patient nutritional status and that nutritional disorders are a serious problem among the elderly , especially those with venous ulcers .',
  'Malnutrition in institutionalized older people is a serious problem having negative impact on patient outcomes .',
  'A 54-year-old profoundly mentally retarded female patient with phenylketonuria and a severe behaviour problem was treated with a restricted protein and high energy diet .',
  'Overnutrition as well as undernutrition is a serious problem in hospitalized patients , especially in infants .',
  'Malnutrition is a serious and relatively common problem among hospitalized patients ; moreover , it is known that a good hydration state contributes to health and wellbeing .',
  'It has been recognized that malnutrition in hospital is a serious problem that may go undetected .',
  'Rehabilitating a child with a severe feeding problem .',
  'Protein-energy malnutrition ( PEM ) is a serious nutritional problem that causes immune dysfunction in elderly people .'],
 'pancreatic': ['Acute pancreatitis represents a significant number of hospital admissions',
  'Sclerosing mesenteritis (SM) and mesenteric panniculitis are rare processes of the mesentery which pose a\xa0major clinical and imaging challenge',
  'Due to difficulty in early diagnosis of chronic pancreatitis (CP), it is urgent to find novel biomarkers to detect CP',
  'Pancreatic cancer (PC) remains difficult to treat, despite the recent advances in various anticancer therapies',
  'The incidence of pancreatic adenocarcinoma (PDAC) in patients with chronic pancreatitis (CP) is as high as 5%',
  'The major problem with using radiation to approximate surgery in unresectable disease is that the radiation dose required to ablate pancreatic cancer exceeds the tolerance of the nearby duodenum .',
  'A high incidence of insulin-dependent diabetes remains the main drawback of pancreatic resection , a problem often difficult to manage in the alcoholic .',
  'The classically used nontargeted chemotherapeutic approach to pancreatic cancer has a dual drawback of suboptimal drug delivery at the target site and the systemic side effects produced by the unfettered exposure of the drug to healthy tissue .',
  'A drawback of islet transplantation is the life-long immunosuppressive medication , often associated with severe side effects .',
  'Pancreatic ductal adenocarcinoma ( PDAC ) is a devastating disease with few therapeutic options , representing one of the great challenges in oncology .',
  'This imposes a serious concern on the genotyping of pancreatitis by a widely used polymerase chain reaction-restriction fragment length polymorphism assay , which could only detect the commonest c.365G > A variant .',
  'Acute thrombosis in human pancreatic transplantation ( HPT ) remains a serious problem occurring in 10 % to 30 % of many reported series .',
  'Pancreatitis remains a serious clinical problem in which imaging plays an important role .',
  'Alcoholic pancreatitis is a serious medical concern worldwide and remains to be one of the common causes of pancreatic disease .',
  'Islet cell tumors make a serious therapeutic problem due to their specific clinical presentation and the necessity of applying a variety of multidisciplinary diagnostic and therapeutic methods .',
  'Pancreatitis caused by activation of digestive zymogens in the exocrine pancreas is a serious chronic health problem in alcoholic patients .',
  'Pancreatic ductal adenocarcinoma is a devastating disease that represents an important health problem .',
  'However , a serious shortage of donor pancreata is a critical problem .',
  'The adequate replacement therapy with pancreatic enzymes , especially in patients with severe exocrine pancreatic insufficiency , is still a serious problem -- requiring sufficient knowledge of the individual pathophysiological circumstances of the patient as well as the various pharmacological aspects of the different types of enzyme drugs .',
  'Acute pancreatitis is a serious clinical problem .',
  'Pancreatic cancer still represents a serious medical concern for which no adequate solution has thus far been found .',
  'Acute lung injury is a severe complication to acute pancreatitis and a significant health problem associated with a considerable mortality .',
  'Shortage of pancreas donor is a severe problem .',
  'Pancreatic leakage continues to occur after pancreaticoduodenectomy ( PD ) and it is a serious problem .',
  'Cystic lesions of the pancreas remain a vexing treatment dilemma , but as we learn more about their natural history , more thoughtful recommendations for management become possible .',
  'Rejection of pancreatic islet grafts is still a serious problem .',
  'The limited availability of human pancreas represents a serious problem in islet transplantation .',
  'However , gene transfer to the pancreas is difficult because of its anatomic location and structure , and pancreatitis is a serious concern .',
  'Necrotizing pancreatitis is a serious medical problem that often requires intervention to debride necrotic pancreatic and peripancreatic tissue .',
  'Marginal ulceration is a serious problem after both standard pancreaticoduodenectomy ( PD ) and pylorus-preserving pancreaticoduodenectomy ( PPPD ) .',
  'Differentiating between mucinous cystic tumors ( MCTs ) and serous cystic tumors ( SCTs ) can be a troubling diagnostic dilemma in pancreatology : when SCTs present in their macro-oligocystic form they must be resected because MCT can not be ruled out , and some tumors considered benign are actually MCTs , which delays diagnosis and places patients at increased risk .',
  'However , a decrease in quality of life becomes a serious problem after total pancreatectomy because of the abolition of endocrine and exocrine pancreatic function .',
  'Acute pancreatitis after delivery is a serious problem compared to other forms of acute pancreatitis .',
  'Despite numerous modifications of surgical technique , pancreatic fistula remains a serious problem and occurs in about 10 % of patients following pancreas resection .',
  'Acute pancreatitis ( AP ) is a serious , unpredictable clinical problem , the pathophysiology of which is poorly understood .',
  'The lack of transplantable pancreatic islets is a serious problem that affects the treatment of patients with type 1 diabetes mellitus .',
  'The islet primary nonfunction ( PNF ) is a serious problem in islet transplantation .',
  'Pancreatic cancer still represents a serious medical concern for which no adequate solution has thus far been found .',
  'Despite of the current achievements of medicine , the mortality of necrotizing pancreatitis ( NP ) is still too high -- up to 35 - 40 % and stands as a serious diagnostic and treatment problem .',
  'Pancreatic acinar cell cultivation poses a serious problem due to limitations in the in vitro survival time despite variations of dissociation protocols , culture media and nutrient supplements .',
  'A severe lack of early diagnosis coupled with resistance to most available therapeutic options renders pancreatic cancer as a major clinical concern .',
  'Biliary and pancreatic involvement , frequently encountered in endemic areas , is a serious public health problem .',
  'Pancreatic cancer remains a devastating problem with the majority of patients succumbing to death from this disease .',
  'Pancreatic fistula is still a serious problem after reconstruction .',
  'Pancreatic ductal adenocarcinoma ( PDAC ) is a deadly disease and a major health problem in the United States .',
  'Acute pancreatitis is a serious surgical problem with a high incidence of mortality .',
  'Consequently , pancreatic cancer represents a serious international problem and requires urgent resolution , especially with regard to its etiology , early diagnosis , prevention , and therapy .',
  'Pancreatic cancer is an aggressive cancer of the digestive system , which is becoming a serious health problem worldwide .',
  'Differentiation between neoplastic and inflammatory pancreatic tumors very often remains a serious clinical problem .',
  'However , the pancreas is difficult to manipulate and pancreatitis is a serious concern , which has made effective gene transfer to this organ elusive .',
  'Magnetic resonance cholangiopancreatography ( MRCP ) is useful for examining the pancreatic duct system in patients with acute pancreatitis instead of using endoscopic retrograde cholangiopancreatography ( ERCP ) , as ERCP-induced pancreatitis represents a serious problem .',
  'Pancreatic fistula ( PF ) after pancreaticoduodenectomy ( PD ) is still a severe complication and a challenging problem .',
  'Substantial decline in pancreas after kidney transplants remains a serious concern .',
  '3 . Carcinoma of the proximal pancreas is a serious medicosurgical problem , and radical pancreatoduodenectomy is the most effective form of therapy .'],
 'pancreatitis': ['Acute pancreatitis represents a significant number of hospital admissions',
  'Sclerosing mesenteritis (SM) and mesenteric panniculitis are rare processes of the mesentery which pose a\xa0major clinical and imaging challenge',
  'Due to difficulty in early diagnosis of chronic pancreatitis (CP), it is urgent to find novel biomarkers to detect CP',
  'Pancreatic cancer (PC) remains difficult to treat, despite the recent advances in various anticancer therapies',
  'The incidence of pancreatic adenocarcinoma (PDAC) in patients with chronic pancreatitis (CP) is as high as 5%',
  'The major problem with using radiation to approximate surgery in unresectable disease is that the radiation dose required to ablate pancreatic cancer exceeds the tolerance of the nearby duodenum .',
  'A high incidence of insulin-dependent diabetes remains the main drawback of pancreatic resection , a problem often difficult to manage in the alcoholic .',
  'The classically used nontargeted chemotherapeutic approach to pancreatic cancer has a dual drawback of suboptimal drug delivery at the target site and the systemic side effects produced by the unfettered exposure of the drug to healthy tissue .',
  'A drawback of islet transplantation is the life-long immunosuppressive medication , often associated with severe side effects .',
  'Pancreatic ductal adenocarcinoma ( PDAC ) is a devastating disease with few therapeutic options , representing one of the great challenges in oncology .',
  'This imposes a serious concern on the genotyping of pancreatitis by a widely used polymerase chain reaction-restriction fragment length polymorphism assay , which could only detect the commonest c.365G > A variant .',
  'Acute thrombosis in human pancreatic transplantation ( HPT ) remains a serious problem occurring in 10 % to 30 % of many reported series .',
  'Pancreatitis remains a serious clinical problem in which imaging plays an important role .',
  'Alcoholic pancreatitis is a serious medical concern worldwide and remains to be one of the common causes of pancreatic disease .',
  'Islet cell tumors make a serious therapeutic problem due to their specific clinical presentation and the necessity of applying a variety of multidisciplinary diagnostic and therapeutic methods .',
  'Pancreatitis caused by activation of digestive zymogens in the exocrine pancreas is a serious chronic health problem in alcoholic patients .',
  'Pancreatic ductal adenocarcinoma is a devastating disease that represents an important health problem .',
  'However , a serious shortage of donor pancreata is a critical problem .',
  'The adequate replacement therapy with pancreatic enzymes , especially in patients with severe exocrine pancreatic insufficiency , is still a serious problem -- requiring sufficient knowledge of the individual pathophysiological circumstances of the patient as well as the various pharmacological aspects of the different types of enzyme drugs .',
  'Acute pancreatitis is a serious clinical problem .',
  'Pancreatic cancer still represents a serious medical concern for which no adequate solution has thus far been found .',
  'Acute lung injury is a severe complication to acute pancreatitis and a significant health problem associated with a considerable mortality .',
  'Shortage of pancreas donor is a severe problem .',
  'Pancreatic leakage continues to occur after pancreaticoduodenectomy ( PD ) and it is a serious problem .',
  'Cystic lesions of the pancreas remain a vexing treatment dilemma , but as we learn more about their natural history , more thoughtful recommendations for management become possible .',
  'Rejection of pancreatic islet grafts is still a serious problem .',
  'The limited availability of human pancreas represents a serious problem in islet transplantation .',
  'However , gene transfer to the pancreas is difficult because of its anatomic location and structure , and pancreatitis is a serious concern .',
  'Necrotizing pancreatitis is a serious medical problem that often requires intervention to debride necrotic pancreatic and peripancreatic tissue .',
  'Marginal ulceration is a serious problem after both standard pancreaticoduodenectomy ( PD ) and pylorus-preserving pancreaticoduodenectomy ( PPPD ) .',
  'Differentiating between mucinous cystic tumors ( MCTs ) and serous cystic tumors ( SCTs ) can be a troubling diagnostic dilemma in pancreatology : when SCTs present in their macro-oligocystic form they must be resected because MCT can not be ruled out , and some tumors considered benign are actually MCTs , which delays diagnosis and places patients at increased risk .',
  'However , a decrease in quality of life becomes a serious problem after total pancreatectomy because of the abolition of endocrine and exocrine pancreatic function .',
  'Acute pancreatitis after delivery is a serious problem compared to other forms of acute pancreatitis .',
  'Despite numerous modifications of surgical technique , pancreatic fistula remains a serious problem and occurs in about 10 % of patients following pancreas resection .',
  'Acute pancreatitis ( AP ) is a serious , unpredictable clinical problem , the pathophysiology of which is poorly understood .',
  'The lack of transplantable pancreatic islets is a serious problem that affects the treatment of patients with type 1 diabetes mellitus .',
  'The islet primary nonfunction ( PNF ) is a serious problem in islet transplantation .',
  'Pancreatic cancer still represents a serious medical concern for which no adequate solution has thus far been found .',
  'Despite of the current achievements of medicine , the mortality of necrotizing pancreatitis ( NP ) is still too high -- up to 35 - 40 % and stands as a serious diagnostic and treatment problem .',
  'Pancreatic acinar cell cultivation poses a serious problem due to limitations in the in vitro survival time despite variations of dissociation protocols , culture media and nutrient supplements .',
  'A severe lack of early diagnosis coupled with resistance to most available therapeutic options renders pancreatic cancer as a major clinical concern .',
  'Biliary and pancreatic involvement , frequently encountered in endemic areas , is a serious public health problem .',
  'Pancreatic cancer remains a devastating problem with the majority of patients succumbing to death from this disease .',
  'Pancreatic fistula is still a serious problem after reconstruction .',
  'Pancreatic ductal adenocarcinoma ( PDAC ) is a deadly disease and a major health problem in the United States .',
  'Acute pancreatitis is a serious surgical problem with a high incidence of mortality .',
  'Consequently , pancreatic cancer represents a serious international problem and requires urgent resolution , especially with regard to its etiology , early diagnosis , prevention , and therapy .',
  'Pancreatic cancer is an aggressive cancer of the digestive system , which is becoming a serious health problem worldwide .',
  'Differentiation between neoplastic and inflammatory pancreatic tumors very often remains a serious clinical problem .',
  'However , the pancreas is difficult to manipulate and pancreatitis is a serious concern , which has made effective gene transfer to this organ elusive .',
  'Magnetic resonance cholangiopancreatography ( MRCP ) is useful for examining the pancreatic duct system in patients with acute pancreatitis instead of using endoscopic retrograde cholangiopancreatography ( ERCP ) , as ERCP-induced pancreatitis represents a serious problem .',
  'Pancreatic fistula ( PF ) after pancreaticoduodenectomy ( PD ) is still a severe complication and a challenging problem .',
  'Substantial decline in pancreas after kidney transplants remains a serious concern .',
  '3 . Carcinoma of the proximal pancreas is a serious medicosurgical problem , and radical pancreatoduodenectomy is the most effective form of therapy .'],
 'pancreas': ['Acute pancreatitis represents a significant number of hospital admissions',
  'Sclerosing mesenteritis (SM) and mesenteric panniculitis are rare processes of the mesentery which pose a\xa0major clinical and imaging challenge',
  'Due to difficulty in early diagnosis of chronic pancreatitis (CP), it is urgent to find novel biomarkers to detect CP',
  'Pancreatic cancer (PC) remains difficult to treat, despite the recent advances in various anticancer therapies',
  'The incidence of pancreatic adenocarcinoma (PDAC) in patients with chronic pancreatitis (CP) is as high as 5%',
  'The major problem with using radiation to approximate surgery in unresectable disease is that the radiation dose required to ablate pancreatic cancer exceeds the tolerance of the nearby duodenum .',
  'A high incidence of insulin-dependent diabetes remains the main drawback of pancreatic resection , a problem often difficult to manage in the alcoholic .',
  'The classically used nontargeted chemotherapeutic approach to pancreatic cancer has a dual drawback of suboptimal drug delivery at the target site and the systemic side effects produced by the unfettered exposure of the drug to healthy tissue .',
  'A drawback of islet transplantation is the life-long immunosuppressive medication , often associated with severe side effects .',
  'Pancreatic ductal adenocarcinoma ( PDAC ) is a devastating disease with few therapeutic options , representing one of the great challenges in oncology .',
  'This imposes a serious concern on the genotyping of pancreatitis by a widely used polymerase chain reaction-restriction fragment length polymorphism assay , which could only detect the commonest c.365G > A variant .',
  'Acute thrombosis in human pancreatic transplantation ( HPT ) remains a serious problem occurring in 10 % to 30 % of many reported series .',
  'Pancreatitis remains a serious clinical problem in which imaging plays an important role .',
  'Alcoholic pancreatitis is a serious medical concern worldwide and remains to be one of the common causes of pancreatic disease .',
  'Islet cell tumors make a serious therapeutic problem due to their specific clinical presentation and the necessity of applying a variety of multidisciplinary diagnostic and therapeutic methods .',
  'Pancreatitis caused by activation of digestive zymogens in the exocrine pancreas is a serious chronic health problem in alcoholic patients .',
  'Pancreatic ductal adenocarcinoma is a devastating disease that represents an important health problem .',
  'However , a serious shortage of donor pancreata is a critical problem .',
  'The adequate replacement therapy with pancreatic enzymes , especially in patients with severe exocrine pancreatic insufficiency , is still a serious problem -- requiring sufficient knowledge of the individual pathophysiological circumstances of the patient as well as the various pharmacological aspects of the different types of enzyme drugs .',
  'Acute pancreatitis is a serious clinical problem .',
  'Pancreatic cancer still represents a serious medical concern for which no adequate solution has thus far been found .',
  'Acute lung injury is a severe complication to acute pancreatitis and a significant health problem associated with a considerable mortality .',
  'Shortage of pancreas donor is a severe problem .',
  'Pancreatic leakage continues to occur after pancreaticoduodenectomy ( PD ) and it is a serious problem .',
  'Cystic lesions of the pancreas remain a vexing treatment dilemma , but as we learn more about their natural history , more thoughtful recommendations for management become possible .',
  'Rejection of pancreatic islet grafts is still a serious problem .',
  'The limited availability of human pancreas represents a serious problem in islet transplantation .',
  'However , gene transfer to the pancreas is difficult because of its anatomic location and structure , and pancreatitis is a serious concern .',
  'Necrotizing pancreatitis is a serious medical problem that often requires intervention to debride necrotic pancreatic and peripancreatic tissue .',
  'Marginal ulceration is a serious problem after both standard pancreaticoduodenectomy ( PD ) and pylorus-preserving pancreaticoduodenectomy ( PPPD ) .',
  'Differentiating between mucinous cystic tumors ( MCTs ) and serous cystic tumors ( SCTs ) can be a troubling diagnostic dilemma in pancreatology : when SCTs present in their macro-oligocystic form they must be resected because MCT can not be ruled out , and some tumors considered benign are actually MCTs , which delays diagnosis and places patients at increased risk .',
  'However , a decrease in quality of life becomes a serious problem after total pancreatectomy because of the abolition of endocrine and exocrine pancreatic function .',
  'Acute pancreatitis after delivery is a serious problem compared to other forms of acute pancreatitis .',
  'Despite numerous modifications of surgical technique , pancreatic fistula remains a serious problem and occurs in about 10 % of patients following pancreas resection .',
  'Acute pancreatitis ( AP ) is a serious , unpredictable clinical problem , the pathophysiology of which is poorly understood .',
  'The lack of transplantable pancreatic islets is a serious problem that affects the treatment of patients with type 1 diabetes mellitus .',
  'The islet primary nonfunction ( PNF ) is a serious problem in islet transplantation .',
  'Pancreatic cancer still represents a serious medical concern for which no adequate solution has thus far been found .',
  'Despite of the current achievements of medicine , the mortality of necrotizing pancreatitis ( NP ) is still too high -- up to 35 - 40 % and stands as a serious diagnostic and treatment problem .',
  'Pancreatic acinar cell cultivation poses a serious problem due to limitations in the in vitro survival time despite variations of dissociation protocols , culture media and nutrient supplements .',
  'A severe lack of early diagnosis coupled with resistance to most available therapeutic options renders pancreatic cancer as a major clinical concern .',
  'Biliary and pancreatic involvement , frequently encountered in endemic areas , is a serious public health problem .',
  'Pancreatic cancer remains a devastating problem with the majority of patients succumbing to death from this disease .',
  'Pancreatic fistula is still a serious problem after reconstruction .',
  'Pancreatic ductal adenocarcinoma ( PDAC ) is a deadly disease and a major health problem in the United States .',
  'Acute pancreatitis is a serious surgical problem with a high incidence of mortality .',
  'Consequently , pancreatic cancer represents a serious international problem and requires urgent resolution , especially with regard to its etiology , early diagnosis , prevention , and therapy .',
  'Pancreatic cancer is an aggressive cancer of the digestive system , which is becoming a serious health problem worldwide .',
  'Differentiation between neoplastic and inflammatory pancreatic tumors very often remains a serious clinical problem .',
  'However , the pancreas is difficult to manipulate and pancreatitis is a serious concern , which has made effective gene transfer to this organ elusive .',
  'Magnetic resonance cholangiopancreatography ( MRCP ) is useful for examining the pancreatic duct system in patients with acute pancreatitis instead of using endoscopic retrograde cholangiopancreatography ( ERCP ) , as ERCP-induced pancreatitis represents a serious problem .',
  'Pancreatic fistula ( PF ) after pancreaticoduodenectomy ( PD ) is still a severe complication and a challenging problem .',
  'Substantial decline in pancreas after kidney transplants remains a serious concern .',
  '3 . Carcinoma of the proximal pancreas is a serious medicosurgical problem , and radical pancreatoduodenectomy is the most effective form of therapy .'],
 'intracerebral': ['Intracerebral hemorrhage (ICH) is a major cause of death and disability globally',
  'Spontaneous supratentorial intracerebral hemorrhage is a vexing clinical problem .',
  'Increased intracranial pressure ( ICP ) is frequently seen , and it is considered a serious problem that needs a careful assessment and management , especially by easy and least invasive modalities .',
  'Intracerebral hemorrhage ( ICH ) is acknowledged as a serious clinical problem lacking effective treatments .',
  'Intracerebral hemorrhage ( ICH ) is a serious public health problem with high rates of death and disability .',
  'Intracerebral hemorrhage ( ICH ) is a serious public health problem which causes high rates of disability and mortality in adults .',
  'Intracerebral hemorrhage ( ICH ) remains a serious clinical problem lacking effective treatment .',
  'As one of the most lethal stroke subtypes , intracerebral hemorrhage ( ICH ) is acknowledged as a serious clinical problem lacking effective treatment .',
  'Spontaneous intracerebral hemorrhage is a serious public health problem and is fatal in 30%-50 % of all occurrences .',
  'Best evidence in anesthetic practice : recombinant activated factor VII for acute intracerebral hemorrhage : a promising therapy for a devastating problem ?',
  'Recurrent hemorrhage is a serious neurosurgical problem in adult moyamoya disease ( MMD ) patients .',
  'Intracerebral hemorrhage ( ICH ) has been becoming a serious public health problem .',
  'Brain edema induced by intracerebral hemorrhage ( ICH ) is a serious problem in the treatment of ICH .',
  'Intracerebral hemorrhage ( ICH ) is the common brain diseases in middle-aged and elderly people , with high disability and/or mortality rate , and is a serious public health concern .'],
 'ich': ['Intracerebral hemorrhage (ICH) is a major cause of death and disability globally',
  'Spontaneous supratentorial intracerebral hemorrhage is a vexing clinical problem .',
  'Increased intracranial pressure ( ICP ) is frequently seen , and it is considered a serious problem that needs a careful assessment and management , especially by easy and least invasive modalities .',
  'Intracerebral hemorrhage ( ICH ) is acknowledged as a serious clinical problem lacking effective treatments .',
  'Intracerebral hemorrhage ( ICH ) is a serious public health problem with high rates of death and disability .',
  'Intracerebral hemorrhage ( ICH ) is a serious public health problem which causes high rates of disability and mortality in adults .',
  'Intracerebral hemorrhage ( ICH ) remains a serious clinical problem lacking effective treatment .',
  'As one of the most lethal stroke subtypes , intracerebral hemorrhage ( ICH ) is acknowledged as a serious clinical problem lacking effective treatment .',
  'Spontaneous intracerebral hemorrhage is a serious public health problem and is fatal in 30%-50 % of all occurrences .',
  'Best evidence in anesthetic practice : recombinant activated factor VII for acute intracerebral hemorrhage : a promising therapy for a devastating problem ?',
  'Recurrent hemorrhage is a serious neurosurgical problem in adult moyamoya disease ( MMD ) patients .',
  'Intracerebral hemorrhage ( ICH ) has been becoming a serious public health problem .',
  'Brain edema induced by intracerebral hemorrhage ( ICH ) is a serious problem in the treatment of ICH .',
  'Intracerebral hemorrhage ( ICH ) is the common brain diseases in middle-aged and elderly people , with high disability and/or mortality rate , and is a serious public health concern .'],
 'hemorrhage': ['Intracerebral hemorrhage (ICH) is a major cause of death and disability globally',
  'Spontaneous supratentorial intracerebral hemorrhage is a vexing clinical problem .',
  'Increased intracranial pressure ( ICP ) is frequently seen , and it is considered a serious problem that needs a careful assessment and management , especially by easy and least invasive modalities .',
  'Subarachnoid hemorrhage ( SAH ) is a devastating form of stroke , which poses a series of intractable challenges to clinical practice .',
  'Aneurysmal subarachnoid hemorrhage ( aSAH ) is a devastating problem .',
  'Intracerebral hemorrhage ( ICH ) is acknowledged as a serious clinical problem lacking effective treatments .',
  'Intracerebral hemorrhage ( ICH ) is a serious public health problem with high rates of death and disability .',
  'Cerebral aneurysm re-rupture following subarachnoid hemorrhage(SAH)is a serious problem that is related with poor outcome .',
  'Intracerebral hemorrhage ( ICH ) is a serious public health problem which causes high rates of disability and mortality in adults .',
  'Intracerebral hemorrhage ( ICH ) remains a serious clinical problem lacking effective treatment .',
  'As one of the most lethal stroke subtypes , intracerebral hemorrhage ( ICH ) is acknowledged as a serious clinical problem lacking effective treatment .',
  'Aneurysmal subarachnoid hemorrhage is a serious medical and social problem .',
  'Spontaneous intracerebral hemorrhage is a serious public health problem and is fatal in 30%-50 % of all occurrences .',
  'Best evidence in anesthetic practice : recombinant activated factor VII for acute intracerebral hemorrhage : a promising therapy for a devastating problem ?',
  'Recurrent hemorrhage is a serious neurosurgical problem in adult moyamoya disease ( MMD ) patients .',
  'Subarachnoid hemorrhage ( SAH ) is a serious medical problem with few effective pharmacotherapies available , and neuroinflammation has been identified as an important pathological process in early brain injury ( EBI ) after SAH .',
  'Cerebral vasospasm secondary to subarachnoid hemorrhage ( SAH ) has been a serious clinical problem .',
  'The development of delayed cerebral ischaemia and hence neurological deficit remains a serious problem following subarachnoid haemorrhage .',
  'While the risk of aneurysmal rebleeding induced by catheter cerebral angiography is a serious concern and can delay angiography for a few hours after a subarachnoid hemorrhage ( SAH ) , current angiographic technology and techniques have been much improved .',
  'Delayed neurologic deficits secondary to vasospasm remain a vexing problem .',
  'Intracerebral hemorrhage ( ICH ) has been becoming a serious public health problem .',
  'Cerebral vasospasm remains a serious problem affecting morbidity and mortality in patients with subarachnoid hemorrhage ( SAH ) during neurosurgery .',
  'Brain edema induced by intracerebral hemorrhage ( ICH ) is a serious problem in the treatment of ICH .',
  'Intracerebral hemorrhage ( ICH ) is the common brain diseases in middle-aged and elderly people , with high disability and/or mortality rate , and is a serious public health concern .',
  'Despite decades of study , subarachnoid hemorrhage ( SAH ) continues to be a serious and significant health problem in the United States and worldwide .',
  'Poor outcome in patients with cerebral vasospasm following subarachnoid hemorrhage remains a serious clinical problem .'],
 'orthodontic': ['Segmental odontomaxillary dysplasia is an uncommon nonhereditary growth disorder that affects the maxilla, gums and ipsilateral dentition',
  'A significant problem with most field dental units is that their suction is too weak to effectively remove debris from the mouth .',
  'The problem with this limited mode of instruction is that dental students often fail to understand the various chairside procedures required to fabricate a complete denture .',
  'The interest in the psychological aspects of orthodontic treatment increases , but a drawback of many studies is that the psychological characteristics of the children themselves are often ignored .',
  'A serious drawback of veneering porcelains is a pronounced susceptibility to chipping .',
  'The treatment of an infected socket with a severe facial dehiscence/ fenestration defect presents a therapeutic dilemma to the dental team .',
  'Stabilization and retention of most of the mandibular full dentures constitute a serious problem for patients and dentists .',
  'Fractured porcelain poses a serious cosmetic and clinical problem .',
  'This has provided the patient , who has a severe dentofacial problem , with the option of having all components of their malocclusion and facial aesthetic concerns addressed .',
  'Hypomineralized second primary molars ( HSPM ) present a serious clinical dilemma for the current practitioners .',
  'Dents occurring in pipes are a severe problem which may lead to the possibility of pipe failure .',
  'Because orthodontic treatment can provide positive benefits , it should not be withheld solely because of the presence of a serious medical problem .',
  'Third molars owing to their most posterior location-limited access coupled with a severe curvature pose utmost clinical challenges require meticulous skill , advanced technology , and patience to achieve success .',
  'This clinical report presents a successful reconstruction of a severe anterior mandibular alveolar bony defect as a result of impacted teeth extraction and periodontal problem in a 50-year-old healthy female patient .',
  'Considering the fact that permanent first molars with severe defects demand complex treatment , they represent a serious problem for the patient as well as for the dentist .',
  'A patient had a serious esthetic problem : One maxillary central incisor was discolored and the other was malpositioned and fractured .',
  'Impacted maxillary canines are a serious problem in orthodontics and prosthodontics .',
  'Dentition discoloration due to intrinsic staining can be a severe esthetic problem .',
  'Successful results obtained in pulp revascularisation after autotransplantation or endodontic regeneration treatments have been reported and pulp tissue functionality after cyst enucleation or apicetomy is a serious concern .',
  'This has provided the patient , who has a severe dentofacial problem , with the option of having all components of their malocclusion and facial aesthetic concerns addressed .',
  'A severe esthetic problem and crowding in the maxillary arch were present clinically .',
  'The loss of anterior teeth is often a serious esthetic concern .',
  'An anterior tooth that is darkened due to intrinsic staining can be a severe esthetic problem .',
  'Upper cuspid impaction is a serious problem that occurs with sufficient frequency to justify diagnosis and intervention as early as a dental age of 8 years .',
  'A severe problem concerns the loss of dental materials ( enamel and dentine ) at the buccal cervical region of the tooth .',
  'Loss of alveolar bone from the edentulous jaws is a serious and common clinical problem , especially among the elderly .',
  'Apical root resorption is a serious iatrogenic problem sometimes associated with orthodontic treatment .',
  'Decalcification during orthodontic treatment is a serious problem .',
  'The ever increasing number of injuries to deciduous teeth in children constitutes a serious problem in paedodontics .',
  'Erosive tooth wear is a serious problem with very costly consequences .',
  'Food impaction after impacted mandibular third molar extraction is a serious problem that should not be ignored .',
  'TDI could be a serious dental public health problem among children .',
  'Cervical or furcal root perforation is a serious clinical problem and one of its treatment modalities is perforation repair with composite resin .',
  'A teamwork approach to correct a severe prosthodontic problem .',
  'A tooth extraction in this patient was complicated by a severe healing problem .',
  'Repairing porcelain restorations has become a serious cosmetic and clinical problem .',
  'Although hypodontia does not represent a serious public health problem , it may cause masticatory and speech dysfunctions and esthetic problems .',
  'Treatment of a skeletodental Class II vertical growth problem , combined with a severe arch length deficiency in both arches , presents a challenging orthodontic problem .',
  'This case report describes a patient in whom orthodontic treatment and poor oral hygiene resulted in a severe mucogingival problem associated with a mandibular incisor tooth .',
  'The resulting reduction of interarch space created a severe prosthetic problem that was resolved by orthodontic management .',
  'Dramatic progress in recent years has made it possible for combined surgical orthodontic treatment to be carried out successfully for patients with a severe dentofacial problem of any type .',
  'The decalcification of enamel is a serious clinical problem in orthodontic patients and is usually observed as white spot lesions surrounding brackets .',
  'Repairing porcelain restorations creates a serious dilemma for the restorative dentist .',
  'Root canal calcification represents a serious problem which often occurs in clinical practice .',
  'En masse retraction of the six anterior teeth by using zygomatic bone anchorage proved to be an efficient method for the correction of a severe overjet problem .',
  'Hypodontia does not represent a serious public health problem , but it may cause masticatory and speech dysfunctions , and esthetic problems .',
  'Although hypodontia does not represent a serious public health problem , it may cause masticatory and speech dysfunctions and esthetic problems .',
  '[ Is tetracycline induced discoloration of the teeth really a serious problem ? ] .',
  'Traumatic dental injuries seem to be a serious dental public health problem among children in deprived areas .',
  'Enamel hypoplasia is a common condition that may present a severe aesthetic problem .'],
 'cardiovascular': ['Atherosclerotic disease is a leading cause of morbidity and mortality in adults and is generally thought of as only affecting adults',
  'The problem with fibrinogen as a clinical tool for predicting coronary events is that laboratory measurement is not standardized , and specific clinical interventions to lower fibrinogen levels are not available .',
  'An additional problem with using absolute risk is that the risk of atherosclerotic disease accumulates over time .',
  'Atherosclerosis is a serious health problem in developed countries and the main cause of morbidity and mortality .',
  'Although , heart disease was recognised as a serious health problem and its occurrence among women recognised , it was predominantly conceived as a health problem affecting men and as being largely due to the relatively unhealthy lifestyles of men .',
  'One-half of the subjects from each cohort had a serious CVD problem and the remaining half were healthy controls .',
  'Cardiovascular disease is the most frequent cause of mortality in the developed countries and represents a serious social , economic and health problem .',
  'The reduction of physical fitness due to the increasing number of cardiovascular risk factors is a serious problem , particularly because it happens in absence of manifest chronic diseases .',
  'Cardiovascular disease is a serious public health problem ; it is the first " cause of death " in Brazil and in developed countries .',
  'Cardiometabolic health status of women is a serious public health concern .',
  'The growing momentum of several common life-style diseases such as myocardial infarction , cardiovascular disorders , stroke , hypertension , diabetes , and atherosclerosis has become a serious global concern .',
  'Ischemic heart disease is a serious health problem because it causes considerable mortality and morbidity .',
  'Cardiovascular disease and the UN millennium development goals : a serious concern .',
  'Cardiovascular disease is a serious problem increasingly affecting young people worldwide .',
  'Cardiovascular disease ( CVD ) is the leading cause of death , globally , and is a serious problem in developing countries .',
  'Despite major advances in the diagnosis and treatment of atherosclerotic cardiovascular disease ( CVD ) in the past century , it remains a serious clinical and public health problem .',
  'Cardiovascular disease is recognized as a serious public health problem .',
  'The cardiovascular system diseases constitute a serious problem for modern medicine .',
  'Cardiovascular diseases are a serious health problem for seafarers .',
  'Cardiovascular disease ( CVD ) has become a serious public health problem in recent years in China .',
  'Cardiovascular disease is a serious problem in the United States .',
  'As you know , atherosclerosis is a serious public problem and is the leading cause of morbidity and mortality not only in Western countries but also in Asia .',
  'In industrialized countries , coronary pathology occupied the first place in terms of morbidity and cardiovascular mortality , affecting more and more frequently younger people , thus constituting a serious problem of public health .',
  'Atherosclerosis is a serious public health concern .',
  'An alarmingly high prevalence of self-reported cardiovascular disease risk factors in 1994 to 1996 , particularly hypertension , leisure-time sedentary lifestyle , and obesity , is a serious public health concern , with implications for future trends in cardiovascular disease mortality .',
  'Coronary heart disease is recognized as a serious public health problem in Western industrialized countries .',
  'Cardiovascular disease remains to be a severe and yet unsolved health problem that has become a leading threat to human health .',
  'Ischemic heart diseases are a serious health problem worldwide .',
  'Cardiovascular disease is the leading cause of global mortality , yet its early detection remains a vexing problem of modern medicine .',
  'Cardiovascular disease is one of the major causes of early morbidity and death in the developed world , and is becoming a serious public health concern in many developing countries .',
  'Heart disease is the leading cause of death among Americans each year , yet the misperception still exists that cardiovascular disease is not a serious health problem for women .',
  'The biggest threat to life are cardiovascular diseases which are a serious problem in Poland , Europe , and worldwide .',
  'Coronary artery disease is a serious health problem worldwide caused by interactions between genetic and environmental risk factors .',
  'Diseases of the cardiovascular system , such as hypertension , myocardial infarction , ischaemia , etc . represent a serious medical problem and a frequent cause of the human death .',
  'Current literature indicates that women , and society in general , do not see coronary heart disease ( CHD ) as a serious concern for women .',
  'Despite impressive gains in diagnosis and treatment , cardiovascular disease ( CVD ) remains a serious clinical problem and threat to public health .',
  'Despite impressive gains in diagnosis and treatment , cardiovascular disease ( CVD ) remains a serious clinical problem and threat to public health .',
  'Coronary artery disease ( CAD ) remains an important cause of morbidity and mortality and is a serious public health problem .',
  'Atherosclerotic coronary artery disease is a serious clinical problem .',
  'Due to the high prevalence of cardiovascular disease in the population , even a modest causal association with ETS would , if valid , constitute a serious public health problem .',
  '[ Cardiology education at each level is still a serious problem ] .',
  'Valvular heart diseases should be regarded as a serious and growing public-health problem .',
  'Despite rapid progress in cardiology and cardiac surgery , cardiovascular disease still present a serious epidemiological problem in industrialized countries , including Poland .',
  'Contrary to popular perceptions , coronary heart disease ( CHD ) is a serious and widespread problem in US women .',
  'Cardiovascular disease ( CAD ) associated with death and disability remains a serious medical problem .',
  'Cardiovascular disease remains a serious medical problem , which can be associated with death and disability on one hand , and considerable resource utilization on the other .',
  'Cardiovascular diseases ( CVD ) remain a serious public health problem and are the primary cause of death worldwide .',
  'Atherosclerosis represents a serious global health problem that demands new therapeutic and prophylactic interventions .'],
 'gastric': ['Primary gastric cancer that presents with peritoneal metastases has few options for successful treatment',
  'Gastric cancer (GC) is general disease in human digestive system with malignancy',
  'Gastric cancer is one of the most common cancers with unsatisfied prognosis',
  'A major problem in treating patients with peritoneal spread from colorectal cancer is that at diagnosis wide peritoneal involvement often precludes all curative attempts .',
  'A drawback of endoscopic submucosal dissection ( ESD ) for early gastric cancer ( EGC ) is the development of metachronous gastric cancer ( MGC ) .',
  'Gastric cancer ( GC ) is still a serious health problem and remains the second most common type of fatal cancer worldwide .',
  'Peritoneal recurrence of gastric cancer patients is a serious problem .',
  'Gastric cancer is a serious public health problem in Northern Brazil and in the world due to its high incidence and mortality .',
  'High false-negative proportion of intraoperative histological examination as a serious problem for clinical application of sentinel node biopsy for early gastric cancer : final results of the Japan Clinical Oncology Group multicenter trial JCOG0302 .',
  'Gastric cancer is a serious health problem worldwide , with particularly high prevalence in eastern Asia .',
  'The gastroenterology specialty could benefit from the introduction of Computer Assisted Decision ( CAD ) systems , since gastric cancer is a serious concern in which an accurate and early diagnosis usually leads to a good prognosis .',
  'Gastric cancer represents a serious health problem on a global scale .',
  'Recently , the number of aged patients with gastric cancer have increased remarkably , indicating a serious diagnostic problem in the near future .',
  'Although peritoneal metastasis is a serious concern in patients with gastric cancer , no acceptable and specific biomarker is available .',
  'Gastric cancer remains a serious public health problem in many regions of the world .',
  '[ Cancer of the stomach -- a serious problem in geriatric surgery ] .',
  'Gastric cancer ( GC ) represents a serious health problem on a global scale .',
  'Although the overall incidence of gastric cancer has been declining in the United States , the disease continues to be a devastating problem worldwide .',
  'gastric cancer is a serious health concern with high morbidity and mortality .',
  'The incidence of gastric cancer is declining in western countries but continues to represent a serious health problem worldwide , especially in Asia and among Asian Americans .',
  'Gastric cancer is a serious problem for human health .',
  'Gastric cancer ( GC ) is a serious health problem worldwide .',
  'Liver metastasis remains a serious problem in the management of gastric cancer ( GC ) .',
  'Gastric cancer remains a serious health concern worldwide .',
  'In regions where screening programs are not widespread , the high number of patients with advanced gastric cancer remains a serious problem to the surgeon .',
  'Gastric cancer ( GC ) is a severe public health problem worldwide , particularly in China .',
  'However , there is a serious problem in patients with gastric cancer after CABG with RGEA graft .',
  'Incidental findings of high-grade dysplasia or gastric cancer at random biopsies with endoscopic diagnosis of chronic gastritis constitute a serious problem to clinical management of patients and sometimes requires blind gastrectomy .',
  'Gastric cancer , despite of its decreasing incidence , remains a serious medical problem .',
  'Gastric cancer remains a serious health problem 5 years survival remains low and early diagnosis anecdotical in France .',
  'Gastric cancer ( GC ) is one of the leading causes of cancer-related deaths worldwide , and its high mortality rate is a serious problem in many regions .',
  'Cancers of the gastrointestinal ( GI ) track are a serious global health problem .',
  'Gastric and colonic cancer , which affect alarmingly also younger age groups to a growing extent , are developing into a serious problem of public health .',
  'Gastric cancer ( GC ) is a highly lethal malignancy and a serious public health concern in East Asia especially in China .',
  'Stomach cancer is a serious public health problem in China .',
  'Gastric cancer can be a fatal tumor and therefore represents one of the primary challenges in modern oncology .',
  'Upper gastrointestinal tumors involving the esophagus and the stomach are a serious public health problem worldwide .',
  'Alimentary tract ( AT ) mucositis is a serious problem complicating cancer treatment , however , its pathobiology remains incompletely understood .',
  'Esophagogastric junction adenocarcinoma ( EGJA ) is a serious public health problem with high mortality in China .'],
 'defibrillator': ['Cardiotocograph (CTG) interpretation is a core skill for health care professionals working on the labour ward; however, training appears to be deficient in respect of the development of decision-making skills relating to CTG findings',
  'A major problem with the use of ambulatory electrocardiographic ( Holter ) monitoring in the diagnosis of arrhythmias is that symptomatic correlation with arrhythmias is rarely found ( only 4 % of patients ) .',
  'The problem with promoting trials that solely determine whether a broad-based population ( identified by one parameter such as ejection fraction that bears no direct relation to the pathogenesis of arrhythmias ) derives a survival benefit from a therapy such as the ICD , is that many patients that could benefit from the ICD are missed ( not covered by the guidelines ) , and many patients that will never benefit from the ICD are exposed to its risks and costs .',
  'However , a persistent problem with these preparations is that , unlike in situ adult ventricular fibres , the isolated fibres usually beat spontaneously .',
  'However , the main problem associated with this method is that the signals recorded from the maternal abdomen are affected by noise and interferences : the maternal electrocardiogram ( mECG ) being the dominant interference .',
  'The problem with these investigations is that they lack sensitivity as they are sometimes normal in patients with documented VT or lack specificity , ventricular arrhythmias being common and often without clinical significance .',
  'The negative inotropic effect of nearly all antiarrhythmic drugs , especially important in patients with impaired left ventricular function , represents a major drawback of medical therapy .',
  'BACKGROUND : The tendency for the electrophysiologic effect of class III antiarrhythmic agents ( action potential prolongation ) to be diminished at faster heart rates represents a major drawback of this class of drug and is usually referred to as " reverse use dependence . " A novel class III agent , MS-551 , has recently been reported to exhibit less reverse use dependence than E-4031 .',
  'A main drawback of the proposed algorithm is however that some arrhythmia types such as left bundle branch block and right bundle branch block beats can not be detected using only the features extracted from the HRV signal .',
  'T wave oversensing ( TWOS ) is a major drawback of the subcutaneous implantable cardioverter defibrillator ( S-ICD ) .',
  'A major drawback of therapy with an implantable defibrillator is the nonspecificity of detection .',
  'Electrical storm ( ES ) is a serious problem in patients with an implantable cardioverter defibrillator ( ICD ) .',
  'T-wave oversensing by an ICD can be a serious problem in some patients , causing overestimation of the heart rate , inappropriate tachyarrhythmia detection and therapy delivery .',
  'Despite advantages , the absence of restriction and regulation had a serious drawback -- there was no governmental agency to ensure that manufacturers would inform physicians of an unreliable pacemaker , and once a manufacturer recognized a problem , it could inform the physician at the most commercially opportune time rather than the earliest , safest time for the patient .',
  'Patients needing an implantable cardioverter defibrillator ( ICD ) system , but without suitable access from jugular or subclavian routes present a vexing problem .',
  'Cardiac abnormalities , often heralded by electrocardiographic alterations , at times may become a serious problem in patients with neuromuscular disorders and occasionally lead to death .',
  'A vexing rhythm problem ?',
  'However , despite these previous approaches , smart clothing for electrocardiography ( ECG ) monitoring has encountered a serious shortcoming relevant to motion artifacts caused by wearer movement .',
  'MRI-induced heating on endocardial leads is a serious concern for the safety of patients with implantable pacemakers or cardioverter-defibrillator .',
  'T-wave oversensing can be a serious problem that often results in inappropriate device therapy .',
  'A slow pulse , on the other hand , could be a sign of a serious electrical problem within the organ or suggest , to the contrary , that a heart is as strong as an ox .',
  'Even though the treatment of arrhythmias is constantly developing , the maintenance of the sinus rhythm ( SR ) is still a serious problem .',
  'This report describes a fatal outcome to this problem despite aggressive medical management , including pervenous cardiac pacing and draws attention to deficiencies in current treatment of a serious problem .',
  'The qualification of patients for ECT and the selection of a group of patients at the highest risk of cardiovascular complications remains a serious clinical problem .',
  'Lead-dependent infective endocarditis ( LDIE ) has emerged as a serious complication of electrotherapy in the era of advanced medical technology and is a growing problem due to greater patient longevity , limited electrode life-time , an increasing number of abandoned leads , and subclinical symptoms .',
  'The frequent occurrence of ventricular tachycardia can create a serious problem in patients with an implantable cardioverter defibrillator .',
  'Ventricular arrhythmias seem to be a serious problem in these patients .',
  'A preventable pacemaker problem .',
  'Lead failure poses a serious problem in pacemaker-dependent patients .',
  'Current physiologic pacemakers : a serious problem with a new device .',
  'High relapse rates after ECT remain a serious and common clinical dilemma .',
  'A panel of experts from Food and Drug Administration did not consider bradyarrhythmias a serious problem in clinical practice and , accordingly , current labeling of the drug does not give any precaution or contraindication regarding this issue .',
  'The frequent occurrence of ventricular tachycardia can be a serious problem for patients with an implantable defibrillator , and may necessitate adjuvant antiarrhythmic therapy or radiofrequency catheter ablation .',
  'Drug-induced proarrhythmia is a serious medical problem that causes relevant morbidity and mortality .',
  'Lead and implantable cardioverter defibrillator ( ICD ) device failure is a severe problem in ICD therapy and may occur without preceding signs of deterioration .',
  'Multiple defibrillator discharges in a short period of time represent a serious problem .',
  'Clinical description and the ECG are fundamental for its analysis , but a serious diagnostic problem arises when these do not provide typical data .',
  '  Heart palpitations may be benign , or they may signal a serious problem .',
  'Runaway pacemaker . A serious and unresolved problem .'],
 'suicide': ['Suicide is an under attended public health problem in Bangladesh as there is no central suicide database and no national suicide surveillance system in the country',
  'India is experiencing increasing suicides that have much economic impact',
  'Suicide is a significant public health issue',
  'The major problem with the use of a rating scale was that , as a one off scoring system , it did not reflect the dynamic nature of suicidal behaviour .',
  'One problem with using recorded rates of suicide is that suicide is a medico-legal verdict and its use by coroners is influenced by a number of factors .',
  'A problem with past research is that it has not adequately incorporated mediating and moderating variables into pathways that link psychosocial stressors and suicidal outcomes .',
  'Suicide is a serious and global health problem that has a strong association with major depressive disorder ( MDD ) .',
  'The program views suicide as a preventable public health problem , and emphasizes treatment of depression and de-stigmatization of mental health illnesses to prevent suicide .',
  'Suicidal behavior is a serious public health problem which is partly heritable .',
  'Suicide is a serious public health problem .',
  'The ability to predict which suicidal patient is at high risk for a serious attempt is an important clinical problem .',
  'This unexpectedly high rate suggests that suicidal behavior is a serious problem among college students and underlines the need for further retrospective studies of the prevalence of suicide attempters .',
  'Suicide is a serious public health concern .',
  'Suicide has been identified as a serious public health problem that is often accompanied by alcohol misuse and dependence .',
  'Despite its decreasing tendency , suicide risk is still a serious problem facing our health care system .',
  'Suicide is a serious and complex public health problem .',
  'Suicide is a serious public health problem around the world .',
  'Suicide attempts are a serious public health concern with devastating global impact , thereby necessitating the development of an adequate prevention strategy .',
  'To mitigate such a serious public health problem , identifying the risk or protective factors of suicide behaviors is crucial .',
  'Although communication is a key component of US strategies to prevent suicide and there are a number of marketing campaigns promoting messages that suicide is a preventable public health problem , there has been little evaluation of these campaigns .',
  'The crisis level in the worldwide suicide rate has revealed a severe suicide problem in Taiwan that is now well above the world average of 16 per 100,000 individuals .',
  'This time lag is a serious concern for the healthcare community when dealing with patients with suicidal thoughts .',
  'Suicidal behaviour still represents a serious public health problem .',
  'Suicide by means of charcoal-burning and jumping from heights has become a serious public health problem in Taiwan .',
  'Suicide is a serious public health problem , including among U.S. Army personnel .',
  'Suicide is 1 of the top 3 leading causes of death in the pediatric population and a serious public health concern .',
  'Suicide is such a serious public health problem that it has been proposed as an indicator of mental health of a society .',
  'Suicidal ideation and attempts are frequent among Tunisian adolescents and represent a serious public health problem .',
  'Suicide is a serious public health problem worldwide , affecting all population groups , regardless of age , gender , or area of residence .',
  'Suicidal behavior in schizoaffective disorder is a serious problem and suicide risk during lifetime ranges between 5%-10 % .',
  'Suicide is a serious mental health problem in old age .',
  'In consideration of the information already available and the findings reported in this study , attempted suicide attempts appear to be a < < symptom > > and not a pathology , at which basis different psychopathological profiles can be found : it is a symptom of a serious emotional and relational problem , which rarely reveals itself suddenly and even more rarely is resolved without help .',
  'Suicide is the second leading cause of death among youth and has become a serious public health problem .',
  'Adolescent depression with related suicidal behavior is a serious health problem .',
  'The cases of non-voluntary euthanasia are a serious problem in the Netherlands and they are only rarely justifiable .',
  'Attempted suicide is a serious problem requiring mental health interventions , but it continues to be treated as a criminal offence under the section 309 of Indian Penal Code .',
  'Suicide : a preventable public health problem .',
  'Suicide has become a serious and growing public health problem in many countries .',
  'Youth suicide is a serious public health problem in the United States .',
  'Suicide is a serious worldwide health problem , particularly among youths .',
  'Suicide is a serious public health problem in the US , yet its neurobiological underpinnings are poorly understood .',
  'Suicide is a serious social problem in many countries , including Japan .',
  'Suicide is the second leading cause of death among youths in many countries , and is a serious concern for public health .',
  'Suicide is a serious public health problem in many countries and has always been a source of apprehension and quest to human mankind , which can be resolved with due diligence .',
  'Suicide is a serious public health problem in Mato Grosso do Sul , and has had an alarming and disproportionate impact on the indigenous population for more than a decade .',
  'Death by suicide is a preventable public health concern worldwide .',
  'Suicidal behavior is a severe public health problem .',
  'These findings suggest that anxiety disorders are independent risk factors for suicide attempts , and underscore the importance of anxiety disorders as a serious public health problem .',
  'Regional disparity in suicide rates is a serious problem worldwide .',
  'Substance abuse is a serious and major public health problem in Iran and potentially increases the risk of suicidal behavior ; therefore , it is essential to increase our knowledge concerning the etiology of suicide among individuals with substance use disorders .',
  'Nonfatal suicidal behaviours ( NSB ) , including suicide ideation , suicide plan and suicide attempt , constitute a serious problem for public healthcare services .',
  'Suicide is a serious public health problem .',
  'Suicide is a serious public health problem worldwide .',
  'Adolescent suicidality is a serious problem among American youth .',
  'Suicide is a serious public health concern in Alberta , with , on average , over 400 Albertans taking their own lives annually .',
  'Suicide is a serious public health problem in low- and middle-income countries .',
  'Suicide is a serious public health concern , and it is partly genetic .',
  'Suicide risk in psychotic patients is a serious but poorly understood clinical and social problem .',
  'These figures indicate that suicidal behaviour among the young constitutes a serious problem for health and welfare services .',
  'Suicide is a serious health problem as it is currently the third leading cause of death for teenagers between the ages of 15 and 24 years .',
  'A change in media trend toward reporting suicide was noted post a celebrity suicide , and it is important that media follow guidelines stringently when reporting a serious problem like suicide .',
  'Suicide is a serious public health problem , being , according to WHO , a third leading cause of death among people aged 15 - 44 .',
  'Suicide is a serious public health concern in the US , especially for those served in outpatient behavioral health .',
  'The economic and human cost of suicidal behavior to individuals , families , communities , and society makes suicide a serious public health concern , both in the US and around the world .',
  'Suicide claims one million lives worldwide annually , making it a serious public health concern .',
  'Suicide is a serious public health problem , with more than 800,000 deaths taking place worldwide each year .',
  'Veteran suicide is a serious public health problem .',
  'Suicide is a serious problem globally , especially in Europe , with suicide rates varying between different countries .',
  'Death by suicide is a serious and growing public health concern in the United States .',
  'Suicide is a serious public health problem , being , according to WHO , a third leading cause of death among people aged 15 - 44 .',
  'Suicide attempts constitute a serious clinical problem .',
  'Suicidal behaviour ( fatal and non-fatal ) has become a serious public health problem in many countries .',
  'Suicide in adolescents and young adults is a serious medical and social problem .',
  'Author notes that inmate suicide continues to pose a serious public health problem within correctional facilities .',
  'Adolescent suicide behavior should be viewed as a serious problem .',
  'The analysis showed that suicide continues to be a serious problem in later life especially among the " oldest-old " ( those aged 85 and over ) and among nonwhite males .',
  "Suicidal behavior is a serious public health concern that has prompted the development of prevention strategies , which include increasing community members ' knowledge about suicide .",
  'Suicide is a serious social problem because over 30,000 people commit suicide every year since 1998 in Japan .',
  'Suicide is a serious public health concern for US youth .',
  'Suicidal behaviour constitutes a serious public as well as mental health problem all over the world .',
  'Suicide is not only a contradictory biological , psychological , sociocultural and spiritual phenomenon , but also a serious public health problem , which is manifold , therefore the fight against it is also complex .',
  'However , the findings did confirm that suicide exists as a serious problem in the society in Kurdistan , particularly among females .',
  'Suicide attempts ( SA ) constitute a serious clinical problem .',
  'Suicidal ideation is a serious mental health concern reported by adolescents .',
  'In adolescents , the prevalence of suicide has increased significantly in recent years , becoming a serious public health concern .',
  'With the population of the elderly increasing , suicides among elderly people present a serious problem for global societies .',
  'Although hospitalization rates for attempted suicide have declined in Brazil , it remains a serious public health problem .',
  'Suicide remains a serious health problem in the United States and worldwide .',
  'Our findings have unveiled that suicide comes forth as a serious public health issue in some municipalities in the state of Amazonas , further indicating that the event occurs within very specific contexts , and that the dimension and the magnitude of the problem can be even more serious among populations or in territories exclusively inhabited by indigenous people .',
  'Inadequate training of nurses in suicide assessment and prevention is a serious patient safety concern .',
  'Suicides and suicidal behaviors are very important causes of mortality and morbidity and have become a serious global problem .',
  'Suicide in the older people is a serious problem worldwide ; however the effect of psychiatric contact on the risk of suicide has not been fully explored .',
  'Suicidality is a serious concern in this country .',
  'Suicide is a serious and extensive problem in the clinical management of schizophrenic patients .',
  'Youth suicide is becoming a serious problem in Kazakhstan .',
  'Although suicide is a preventable public health problem , objective assays for suicide risk are limited .',
  'Introduction : Suicide is a serious social and public health problem that affects the population in most countries in the world .',
  'Suicide is a serious public health concern , but little is known about the relationship between access to mental health care and suicide deaths , and whether suicide rates differ by mental health provider Health Professional Shortage Areas ( HPSAs ) .',
  'Suicide is a serious public health problem worldwide , and many nations are committed to developing prevention programmes to reduce the incidence of suicide .',
  'Suicide is a serious public health problem but a problem that is preventable .',
  'However , the findings did confirm that suicide exists as a serious problem in the society in Kurdistan , particularly among females .',
  'The suicide rate in Minnesota has increased every year since 2000 , making suicide a serious public health problem .',
  'Suicide is a serious public health concern that is responsible for almost 1 million deaths each year worldwide .',
  'Suicide behavior is a serious clinical problem worldwide , and understanding ways of reducing it is a priority .',
  'Suicide is a preventable public health problem and a leading cause of death in the United States .',
  'Suicide is a serious public health problem worldwide .',
  'Suicide remains a serious health care problem and a sentinel event tracked by The Joint Commission .',
  "Healthcare workers ' failure to recognize suicide as a serious problem suggests that the formal health system is currently ill-equipped to respond to suicide-related needs .",
  'Suicide is a serious public health concern in the world .',
  'Depression and suicide present a serious health problem especially for teenagers as they are increasingly diagnosed with mood disorders of different severity , possibly leading to suicidal activity .',
  'Global suicide rates have increased in recent decades becoming a serious social and public health problem .',
  'Suicide is a serious public health concern all over the world including Bangladesh .',
  'Suicide is a serious public health problem in the United States , and suicide rates have been increasing for more than a decade .',
  'Suicide is a serious public health concern worldwide , and the fourth leading cause of death in Korea .',
  'Suicide is a serious problem in East Asia . Yet , there is a significant lack of research on the topic , particularly using qualitative methodology .',
  'Suicide and attempted suicide are identified as a serious mental health problem in Suriname , especially in the district of Nickerie .',
  'Earlier studies among the other main ethnic groups in the country showed suicidal behavior in those groups to be a serious problem .',
  'Suicide ideation is a serious concern for the health of LGBT Nebraskans .',
  'Suicide attempts constitute a serious clinical problem and have important implications for healthcare resources .',
  'Suicide and suicide attempts represent a severe problem for public health services .',
  'Suicide is a leading cause of death and represents a serious public health concern .',
  'Women and Suicide : Moving Forward on a Troubling Problem .',
  'Suicidal behaviours are internationally considered as a serious health problem and , consequently , considerable efforts are being made in the search for factors related with this behaviour .',
  'Suicide is a preventable public health problem .',
  'Suicide is a serious and growing public health concern , both for the United States ( U.S. ) and for the Department of Defense ( DoD ) .',
  'Studied mostly in developed countries , the increased prevalence of suicide among youth , worldwide , is a preventable public health concern .',
  'Suicide is a serious global public health problem and the third leading cause of death in those 15 - 35 years old .',
  'Suicide is a serious social and public health problem .',
  'Suicide and suicidal behavior in the pediatric population is a serious public health problem .',
  '[ Suicide a serious health and social problem with the possibility of prevention ] .',
  'Suicide is a serious and increasing problem worldwide .',
  'Suicide has been identified as a serious public health problem which is receiving increasing attention .',
  'Suicide is a devastating public health problem and very few biological treatments have been found to be effective for quickly reducing the intensity of suicidal ideation ( SI ) .',
  'Adolescent suicide has become a serious public health problem in China .',
  "Most participants agreed that the suicidal subject had a serious problem , with seriousness of the problem decreasing with participant 's age .",
  'Suicide is a serious public health problem .',
  'Consultant pharmacists need to be aware that suicide is a serious concern for elders .',
  'Suicide is a preventable health problem .',
  'Suicidal behavior is a severe problem among drug users .',
  'The high frequency of suicide attempts during adolescence is a serious public health concern .',
  'Though , suicide is a preventable public health problem but prediction is almost impossible .',
  'Suicide is a serious public health problem .',
  'Suicide is a serious public health problem , and training in suicide prevention has not kept pace with recent rapid growth of the field .',
  'Suicide is a devastating public health problem , and research indicates that people with prior attempts are at the greatest risk of completing suicide , followed by persons with depression and other major mental and substance use conditions .',
  'Suicide is a serious public health concern .',
  'The prevalence of Korean adolescents with depression was 25.1 % in 2017 , and the suicide rate among Korean teens increased from 4.2 deaths per 100,000 in 2015 to 4.9 deaths per 100,000 in 2016 , suggesting that a high prevalence of depression and suicide among adolescents is a serious social problem in South Korea .',
  'Although suicide-related outcomes among Asian American adolescents are a serious public health problem in the United States , research in this area has been relatively sparse .',
  'Suicide is a serious public health problem , and suicide rates are particularly high in South Korea .'],
 'suicidal': ['Suicide is an under attended public health problem in Bangladesh as there is no central suicide database and no national suicide surveillance system in the country',
  'India is experiencing increasing suicides that have much economic impact',
  'Suicide is a significant public health issue',
  'The major problem with the use of a rating scale was that , as a one off scoring system , it did not reflect the dynamic nature of suicidal behaviour .',
  'One problem with using recorded rates of suicide is that suicide is a medico-legal verdict and its use by coroners is influenced by a number of factors .',
  'A problem with past research is that it has not adequately incorporated mediating and moderating variables into pathways that link psychosocial stressors and suicidal outcomes .',
  'Suicide is a serious and global health problem that has a strong association with major depressive disorder ( MDD ) .',
  'Nonsuicidal self-injury ( NSSI ) is a serious public health concern among adolescents .',
  'The program views suicide as a preventable public health problem , and emphasizes treatment of depression and de-stigmatization of mental health illnesses to prevent suicide .',
  'Suicidal behavior is a serious public health problem which is partly heritable .',
  'Suicide is a serious public health problem .',
  'The ability to predict which suicidal patient is at high risk for a serious attempt is an important clinical problem .',
  'Self-harm thoughts and behaviours ( SHTBs ) are a serious public health concern in young people .',
  'This unexpectedly high rate suggests that suicidal behavior is a serious problem among college students and underlines the need for further retrospective studies of the prevalence of suicide attempters .',
  'Suicide is a serious public health concern .',
  'Suicide has been identified as a serious public health problem that is often accompanied by alcohol misuse and dependence .',
  'Despite its decreasing tendency , suicide risk is still a serious problem facing our health care system .',
  'Suicide is a serious and complex public health problem .',
  'Suicide is a serious public health problem around the world .',
  'Suicide attempts are a serious public health concern with devastating global impact , thereby necessitating the development of an adequate prevention strategy .',
  'To mitigate such a serious public health problem , identifying the risk or protective factors of suicide behaviors is crucial .',
  'Although communication is a key component of US strategies to prevent suicide and there are a number of marketing campaigns promoting messages that suicide is a preventable public health problem , there has been little evaluation of these campaigns .',
  'The crisis level in the worldwide suicide rate has revealed a severe suicide problem in Taiwan that is now well above the world average of 16 per 100,000 individuals .',
  'This time lag is a serious concern for the healthcare community when dealing with patients with suicidal thoughts .',
  'Suicidal behaviour still represents a serious public health problem .',
  'Suicide by means of charcoal-burning and jumping from heights has become a serious public health problem in Taiwan .',
  'Self-injurious behaviors in adolescence are a serious public health concern .',
  'Suicide is a serious public health problem , including among U.S. Army personnel .',
  'Suicide is 1 of the top 3 leading causes of death in the pediatric population and a serious public health concern .',
  'Suicide is such a serious public health problem that it has been proposed as an indicator of mental health of a society .',
  'Suicidal ideation and attempts are frequent among Tunisian adolescents and represent a serious public health problem .',
  'Suicide is a serious public health problem worldwide , affecting all population groups , regardless of age , gender , or area of residence .',
  'Suicidal behavior in schizoaffective disorder is a serious problem and suicide risk during lifetime ranges between 5%-10 % .',
  'Suicide is a serious mental health problem in old age .',
  'In consideration of the information already available and the findings reported in this study , attempted suicide attempts appear to be a < < symptom > > and not a pathology , at which basis different psychopathological profiles can be found : it is a symptom of a serious emotional and relational problem , which rarely reveals itself suddenly and even more rarely is resolved without help .',
  'Adolescent suicide is a serious public health problem , and non-suicidal self-injury ( NSSI ) is both highly comorbid with suicidality among adolescents and a significant predictor of suicide attempts ( SAs ) in adolescents .',
  'Suicide is the second leading cause of death among youth and has become a serious public health problem .',
  'Adolescent depression with related suicidal behavior is a serious health problem .',
  'The cases of non-voluntary euthanasia are a serious problem in the Netherlands and they are only rarely justifiable .',
  'Attempted suicide is a serious problem requiring mental health interventions , but it continues to be treated as a criminal offence under the section 309 of Indian Penal Code .',
  'Suicide : a preventable public health problem .',
  'Suicide has become a serious and growing public health problem in many countries .',
  'Youth suicide is a serious public health problem in the United States .',
  'Suicide is a serious worldwide health problem , particularly among youths .',
  'Suicide is a serious public health problem in the US , yet its neurobiological underpinnings are poorly understood .',
  'Self-injurious behavior ( e.g. , nonsuicidal self-injury , suicide attempts ) is a serious public health concern .',
  'Suicide is a serious social problem in many countries , including Japan .',
  'Suicide is the second leading cause of death among youths in many countries , and is a serious concern for public health .',
  'Suicide is a serious public health problem in many countries and has always been a source of apprehension and quest to human mankind , which can be resolved with due diligence .',
  'Suicide is a serious public health problem in Mato Grosso do Sul , and has had an alarming and disproportionate impact on the indigenous population for more than a decade .',
  'Death by suicide is a preventable public health concern worldwide .',
  'Suicidal behavior is a severe public health problem .',
  'These findings suggest that anxiety disorders are independent risk factors for suicide attempts , and underscore the importance of anxiety disorders as a serious public health problem .',
  'Regional disparity in suicide rates is a serious problem worldwide .',
  'Substance abuse is a serious and major public health problem in Iran and potentially increases the risk of suicidal behavior ; therefore , it is essential to increase our knowledge concerning the etiology of suicide among individuals with substance use disorders .',
  'Nonfatal suicidal behaviours ( NSB ) , including suicide ideation , suicide plan and suicide attempt , constitute a serious problem for public healthcare services .',
  'Suicide is a serious public health problem .',
  'Non-suicidal self-injury ( NSSI ) is a serious public health concern facing adolescents and young adults worldwide .',
  'Suicide is a serious public health problem worldwide .',
  'Adolescent suicidality is a serious problem among American youth .',
  'Suicide is a serious public health concern in Alberta , with , on average , over 400 Albertans taking their own lives annually .',
  'Suicide is a serious public health problem in low- and middle-income countries .',
  'Suicide is a serious public health concern , and it is partly genetic .',
  'Nonsuicidal self-injury in men : a serious problem that has been overlooked for too long .',
  'Suicide risk in psychotic patients is a serious but poorly understood clinical and social problem .',
  'These figures indicate that suicidal behaviour among the young constitutes a serious problem for health and welfare services .',
  'Suicide is a serious health problem as it is currently the third leading cause of death for teenagers between the ages of 15 and 24 years .',
  'A change in media trend toward reporting suicide was noted post a celebrity suicide , and it is important that media follow guidelines stringently when reporting a serious problem like suicide .',
  'Suicide is a serious public health problem , being , according to WHO , a third leading cause of death among people aged 15 - 44 .',
  'Suicide is a serious public health concern in the US , especially for those served in outpatient behavioral health .',
  'The economic and human cost of suicidal behavior to individuals , families , communities , and society makes suicide a serious public health concern , both in the US and around the world .',
  'Suicide claims one million lives worldwide annually , making it a serious public health concern .',
  'Suicide is a serious public health problem , with more than 800,000 deaths taking place worldwide each year .',
  'Veteran suicide is a serious public health problem .',
  'Suicide is a serious problem globally , especially in Europe , with suicide rates varying between different countries .',
  'Death by suicide is a serious and growing public health concern in the United States .',
  'Self-harm is a serious risk factor for suicide , a major public health concern , and a significant burden on the NHS .',
  'Suicide is a serious public health problem , being , according to WHO , a third leading cause of death among people aged 15 - 44 .',
  'Suicide attempts constitute a serious clinical problem .',
  'Adolescent self-harm is recognized as a serious public health problem ; however , there is little reliable comparative data on its prevalence or characteristics , or on the extent of help-seeking for self-harm .',
  'Suicidal behaviour ( fatal and non-fatal ) has become a serious public health problem in many countries .',
  'Suicide in adolescents and young adults is a serious medical and social problem .',
  'Author notes that inmate suicide continues to pose a serious public health problem within correctional facilities .',
  'Adolescent suicide behavior should be viewed as a serious problem .',
  'The analysis showed that suicide continues to be a serious problem in later life especially among the " oldest-old " ( those aged 85 and over ) and among nonwhite males .',
  "Suicidal behavior is a serious public health concern that has prompted the development of prevention strategies , which include increasing community members ' knowledge about suicide .",
  'Suicide is a serious social problem because over 30,000 people commit suicide every year since 1998 in Japan .',
  'Suicide is a serious public health concern for US youth .',
  'Despite recent advances in the understanding and treatment of self-harm , poor engagement with therapy remains a serious problem .',
  'Suicidal behaviour constitutes a serious public as well as mental health problem all over the world .',
  'Suicide is not only a contradictory biological , psychological , sociocultural and spiritual phenomenon , but also a serious public health problem , which is manifold , therefore the fight against it is also complex .',
  'However , the findings did confirm that suicide exists as a serious problem in the society in Kurdistan , particularly among females .',
  'Suicide attempts ( SA ) constitute a serious clinical problem .',
  'Suicidal ideation is a serious mental health concern reported by adolescents .',
  'In adolescents , the prevalence of suicide has increased significantly in recent years , becoming a serious public health concern .',
  'With the population of the elderly increasing , suicides among elderly people present a serious problem for global societies .',
  'Self harm is a serious public health problem worldwide .',
  'Self-harm represents a serious and pathological behavior that occurs most notably during adolescent years and currently seems to be a problem that is on the increase .',
  'Although hospitalization rates for attempted suicide have declined in Brazil , it remains a serious public health problem .',
  'Suicide remains a serious health problem in the United States and worldwide .',
  'Our findings have unveiled that suicide comes forth as a serious public health issue in some municipalities in the state of Amazonas , further indicating that the event occurs within very specific contexts , and that the dimension and the magnitude of the problem can be even more serious among populations or in territories exclusively inhabited by indigenous people .',
  'Inadequate training of nurses in suicide assessment and prevention is a serious patient safety concern .',
  'Suicides and suicidal behaviors are very important causes of mortality and morbidity and have become a serious global problem .',
  'Suicide in the older people is a serious problem worldwide ; however the effect of psychiatric contact on the risk of suicide has not been fully explored .',
  'Suicidality is a serious concern in this country .',
  'Suicide is a serious and extensive problem in the clinical management of schizophrenic patients .',
  'Self-harm remains a serious public health concern , not least because of its strong link with suicide .',
  'Youth suicide is becoming a serious problem in Kazakhstan .',
  'Although suicide is a preventable public health problem , objective assays for suicide risk are limited .',
  'Non-suicidal self-injury ( NSSI ) is a serious clinical problem that is common in adolescents .',
  'Introduction : Suicide is a serious social and public health problem that affects the population in most countries in the world .',
  'Suicide is a serious public health concern , but little is known about the relationship between access to mental health care and suicide deaths , and whether suicide rates differ by mental health provider Health Professional Shortage Areas ( HPSAs ) .',
  'Suicide is a serious public health problem worldwide , and many nations are committed to developing prevention programmes to reduce the incidence of suicide .',
  'Suicide is a serious public health problem but a problem that is preventable .',
  'However , the findings did confirm that suicide exists as a serious problem in the society in Kurdistan , particularly among females .',
  'The suicide rate in Minnesota has increased every year since 2000 , making suicide a serious public health problem .',
  'Suicide is a serious public health concern that is responsible for almost 1 million deaths each year worldwide .',
  'Suicide behavior is a serious clinical problem worldwide , and understanding ways of reducing it is a priority .',
  'Suicide is a preventable public health problem and a leading cause of death in the United States .',
  'Suicide is a serious public health problem worldwide .',
  'Although non-suicidal self-injury ( nssi ) is a serious health concern among prisoners worldwide , no empirical data on this issue are currently available specifically for Belgium.<br/ > AIM : To investigate the prevalence rates of , and risk factors for , nssi in Flemish prisons.<br/ > METHOD : A cross-sectional study based on a representative sample of 1326 prisoners ( 1203 men and 123 women ) , randomly selected from 15 Flemish prisons.<br/ > RESULTS : Overall , 17.3 % of prisoners self-reported a lifetime history of nssi .',
  'Suicide remains a serious health care problem and a sentinel event tracked by The Joint Commission .',
  "Healthcare workers ' failure to recognize suicide as a serious problem suggests that the formal health system is currently ill-equipped to respond to suicide-related needs .",
  'Self-inflicted injury ( SII ) in adolescence is a serious public health concern that portends prospective vulnerability to internalizing and externalizing psychopathology , borderline personality development , suicide attempts , and suicide .',
  'Non-suicidal self-injury ( NSSI ) is a serious public health concern in adolescents .',
  'Suicide is a serious public health concern in the world .',
  'Depression and suicide present a serious health problem especially for teenagers as they are increasingly diagnosed with mood disorders of different severity , possibly leading to suicidal activity .',
  'Global suicide rates have increased in recent decades becoming a serious social and public health problem .',
  'Suicide is a serious public health concern all over the world including Bangladesh .',
  'Suicide is a serious public health problem in the United States , and suicide rates have been increasing for more than a decade .',
  'Suicide is a serious public health concern worldwide , and the fourth leading cause of death in Korea .',
  'Nonsuicidal self-injury ( NSSI ) is a serious and prevalent problem within the adolescent population .',
  'Suicide is a serious problem in East Asia . Yet , there is a significant lack of research on the topic , particularly using qualitative methodology .',
  'Self-harm in young people continues to be a serious concern for health services globally .',
  'Suicide and attempted suicide are identified as a serious mental health problem in Suriname , especially in the district of Nickerie .',
  'Earlier studies among the other main ethnic groups in the country showed suicidal behavior in those groups to be a serious problem .',
  'Suicide ideation is a serious concern for the health of LGBT Nebraskans .',
  'Self-harm remains a serious public health concern ; however , identifying adolescents at risk is challenging .',
  'Non-suicidal self-injury ( NSSI ) is a serious public health concern and remains poorly understood .',
  'Suicide attempts constitute a serious clinical problem and have important implications for healthcare resources .',
  'Recently self-injurious behavior including wrist-cutting among youth has been a serious problem in Japan .',
  'Suicide and suicide attempts represent a severe problem for public health services .',
  'Suicide is a leading cause of death and represents a serious public health concern .',
  'Women and Suicide : Moving Forward on a Troubling Problem .',
  'Suicidal behaviours are internationally considered as a serious health problem and , consequently , considerable efforts are being made in the search for factors related with this behaviour .',
  'Suicide is a preventable public health problem .',
  'Suicide is a serious and growing public health concern , both for the United States ( U.S. ) and for the Department of Defense ( DoD ) .',
  'Studied mostly in developed countries , the increased prevalence of suicide among youth , worldwide , is a preventable public health concern .',
  'Suicide is a serious global public health problem and the third leading cause of death in those 15 - 35 years old .',
  'Self-injury is a dangerous and pervasive behavior problem among adolescents .',
  'Suicide is a serious social and public health problem .',
  'Suicide and suicidal behavior in the pediatric population is a serious public health problem .',
  '[ Suicide a serious health and social problem with the possibility of prevention ] .',
  'Suicide is a serious and increasing problem worldwide .',
  'Suicide has been identified as a serious public health problem which is receiving increasing attention .',
  'Suicide is a devastating public health problem and very few biological treatments have been found to be effective for quickly reducing the intensity of suicidal ideation ( SI ) .',
  'Adolescent suicide has become a serious public health problem in China .',
  "Most participants agreed that the suicidal subject had a serious problem , with seriousness of the problem decreasing with participant 's age .",
  'Suicide is a serious public health problem .',
  'Consultant pharmacists need to be aware that suicide is a serious concern for elders .',
  'Suicide is a preventable health problem .',
  'Suicidal behavior is a severe problem among drug users .',
  'The high frequency of suicide attempts during adolescence is a serious public health concern .',
  'Though , suicide is a preventable public health problem but prediction is almost impossible .',
  'Suicide is a serious public health problem .',
  'Suicide is a serious public health problem , and training in suicide prevention has not kept pace with recent rapid growth of the field .',
  'Suicide is a devastating public health problem , and research indicates that people with prior attempts are at the greatest risk of completing suicide , followed by persons with depression and other major mental and substance use conditions .',
  'Self-harm is a severe health problem worldwide and in particular in clinical settings .',
  'Suicide is a serious public health concern .',
  'The prevalence of Korean adolescents with depression was 25.1 % in 2017 , and the suicide rate among Korean teens increased from 4.2 deaths per 100,000 in 2015 to 4.9 deaths per 100,000 in 2016 , suggesting that a high prevalence of depression and suicide among adolescents is a serious social problem in South Korea .',
  'Nonsuicidal self-injury ( NSSI ) is a serious public health problem .',
  'Although suicide-related outcomes among Asian American adolescents are a serious public health problem in the United States , research in this area has been relatively sparse .',
  'Suicide is a serious public health problem , and suicide rates are particularly high in South Korea .'],
 'workplace': ['Although prior studies demonstrate that "soft skills" are necessary for workplace success, few consider the emphasis faculty place on teaching soft skills',
  'Incivility in academic workplaces can have detrimental effects on individuals, teams, departments, and the campus community at large',
  'Workplace incivility is a common problem in nursing, and novice nurses are particularly vulnerable to incivility',
  'Bullying in the workplace is a serious public health issue',
  'The collected data show that aggressive behaviors at work is a serious and challenging problem that may affect the performance and health of employees .',
  'Bullying is a serious problem in this group of workers and may lead to health consequences .',
  'Bullying is a serious problem in workplaces with consequences for the individual , the organisation and the quality of care .',
  'Clinician safety is a serious concern for health care professionals because of the great risk of violence in health care workplaces , especially emergency and mental health departments .',
  'Workplace violence is a serious public problem affecting millions of women employees each year throughout the world .',
  'Workplace violence is a serious occupational health problem .',
  "Workplace violence is a serious concern for workers ' mental health and well-being in high risk work sectors .",
  'Violence against health care workers is a serious and growing problem .',
  'Aggression in the workplace is increasingly recognized as a serious problem , but there are few studies about worker aggression toward outsiders in the workplace .',
  'Violence is a serious problem confronting primary care practitioners .',
  'Workplace violence is becoming increasingly recognized as a serious problem in health care settings .',
  'Workplace bullying is a serious problem faced by nurses nationally .',
  'Although bullying has been identified as a serious problem in the health care sector , little attention has been given to the possible effect of workplace bullying on long-term sickness absence and its implications .',
  'Workplace violence ( WPV ) is a serious problem in health care in Taiwan , as it is worldwide .',
  'Bullying in nursing workplaces has been considered a serious problem that increases nurse turnover .',
  'Exposure to workplace bullying has been argued to be a severe social stressor and a more crippling and devastating problem for affected individuals than the effects of all other work-related stressors put together .',
  'Workplace violence is a serious and multidimensional problem that adversely affects professional and personal lives of employees .',
  'Workplace violence is a serious , increasingly common problem in OHSN-participating hospitals .',
  'Violence against doctors in China is a serious problem that has attracted attention from both domestic and international media .',
  'Aggression is a serious problem in the Hungarian health care system , therefore employees have to be prepared for these acts .',
  'Workplace aggression constitutes a serious problem in individual , organizational and social cause-effect relations .',
  'However , workplace violence represents a serious threat to workplace safety and has become a global public health problem .',
  'Workplace bullying is a serious problem affecting nursing .',
  'Violence against nursing personnel in their place of work is a severe problem generating important consequences for these workers . Even though there is a large body of research on the subject , the emotional impact of aggression against healthcare workers continues to be debated .',
  'Lateral violence is a serious occupational health concern among nurses as evidenced by extensive research and literature available on the topic .',
  'Work-related violence is a major public health problem ; however , there is a serious deficiency in the knowledge of risk factors for this problem .',
  'Recent evidence describes workplace incivility as a serious concern in the healthcare setting worldwide .',
  'Workplace violence towards nurses is a serious problem internationally , and violence prevention strategies need to be implemented .',
  'Despite prevention and intervention measures , experts predict that assault in hospitals will continue to be a serious problem .',
  'Workplace bullying is increasingly being recognized as a serious problem within the work environment .',
  'Bullying is a serious and growing problem affecting a significant proportion of healthcare professionals , a professional category exposed to work-related stress .',
  'Workplace violence is a serious and growing problem that affects all healthcare professionals .',
  'Workplace bullying seems to be a serious problem in the French working life given the prevalence observed here ( around 10 % ) .',
  'Workplace violence against nurses is a serious problem .',
  'Emergency departments are considered high-risk areas , where violence against nurses is a serious and prevalent problem .',
  'Workplace violence , a dangerous and complex occupational hazard in the modern health care work environment , presents challenges for nurses , other health care employees , management , labor unions , and regulators .',
  'Workplace bullying among nurse educators is a serious problem impacting the profession .',
  'General impressions existed that violence appeared to be a serious problem in the hospital in Tel Aviv , whereas there are scarcely any reports of violence in general hospitals in the Netherlands .',
  'Workplace violence is a serious occupational problem among nurses in emergency departments .',
  'Violence in the workplace is a serious social and public health problem .',
  'Violence against humanitarian health care workers and facilities in situations of armed conflict is a serious humanitarian problem . Targeting health care workers and destroying or looting medical facilities directly or indirectly impacts the delivery of emergency and life-saving medical assistance , often at a time when it is most needed .',
  'Workplace bullying is a serious problem that hinders the provision of quality care services by seriously affecting their physical , psychological , and social health status .',
  'Violence in the workplace is a serious public health problem .',
  'Violence against nurses is a serious problem that can affect negatively the quality of nursing care .',
  'Bullying remains a troubling problem in the nursing profession .',
  'Workplace violence is a serious problem for clinical nurses , as it leads to a series of adverse consequences .',
  'Violence against doctors , a serious concern for healthcare organizations to ponder about .'],
 'employees': ['Although prior studies demonstrate that "soft skills" are necessary for workplace success, few consider the emphasis faculty place on teaching soft skills',
  'Incivility in academic workplaces can have detrimental effects on individuals, teams, departments, and the campus community at large',
  'Workplace incivility is a common problem in nursing, and novice nurses are particularly vulnerable to incivility',
  'The collected data show that aggressive behaviors at work is a serious and challenging problem that may affect the performance and health of employees .',
  'Clinician safety is a serious concern for health care professionals because of the great risk of violence in health care workplaces , especially emergency and mental health departments .',
  'Workplace violence is a serious public problem affecting millions of women employees each year throughout the world .',
  'Workplace violence is a serious occupational health problem .',
  "Workplace violence is a serious concern for workers ' mental health and well-being in high risk work sectors .",
  'Violence against health care workers is a serious and growing problem .',
  'Aggression in the workplace is increasingly recognized as a serious problem , but there are few studies about worker aggression toward outsiders in the workplace .',
  'Violence is a serious problem confronting primary care practitioners .',
  'Workplace violence is becoming increasingly recognized as a serious problem in health care settings .',
  'Workplace violence ( WPV ) is a serious problem in health care in Taiwan , as it is worldwide .',
  'Workplace violence is a serious and multidimensional problem that adversely affects professional and personal lives of employees .',
  'Workplace violence is a serious , increasingly common problem in OHSN-participating hospitals .',
  'Violence against doctors in China is a serious problem that has attracted attention from both domestic and international media .',
  'Aggression is a serious problem in the Hungarian health care system , therefore employees have to be prepared for these acts .',
  'Workplace aggression constitutes a serious problem in individual , organizational and social cause-effect relations .',
  'However , workplace violence represents a serious threat to workplace safety and has become a global public health problem .',
  'Violence against nursing personnel in their place of work is a severe problem generating important consequences for these workers . Even though there is a large body of research on the subject , the emotional impact of aggression against healthcare workers continues to be debated .',
  'Lateral violence is a serious occupational health concern among nurses as evidenced by extensive research and literature available on the topic .',
  'Work-related violence is a major public health problem ; however , there is a serious deficiency in the knowledge of risk factors for this problem .',
  'Recent evidence describes workplace incivility as a serious concern in the healthcare setting worldwide .',
  'Workplace violence towards nurses is a serious problem internationally , and violence prevention strategies need to be implemented .',
  'Despite prevention and intervention measures , experts predict that assault in hospitals will continue to be a serious problem .',
  'Workplace violence is a serious and growing problem that affects all healthcare professionals .',
  'Workplace violence against nurses is a serious problem .',
  'Emergency departments are considered high-risk areas , where violence against nurses is a serious and prevalent problem .',
  'Workplace violence , a dangerous and complex occupational hazard in the modern health care work environment , presents challenges for nurses , other health care employees , management , labor unions , and regulators .',
  'General impressions existed that violence appeared to be a serious problem in the hospital in Tel Aviv , whereas there are scarcely any reports of violence in general hospitals in the Netherlands .',
  'Workplace violence is a serious occupational problem among nurses in emergency departments .',
  'Violence in the workplace is a serious social and public health problem .',
  'Violence against humanitarian health care workers and facilities in situations of armed conflict is a serious humanitarian problem . Targeting health care workers and destroying or looting medical facilities directly or indirectly impacts the delivery of emergency and life-saving medical assistance , often at a time when it is most needed .',
  'Violence in the workplace is a serious public health problem .',
  'Violence against nurses is a serious problem that can affect negatively the quality of nursing care .',
  'Workplace violence is a serious problem for clinical nurses , as it leads to a series of adverse consequences .',
  'Violence against doctors , a serious concern for healthcare organizations to ponder about .'],
 'smoking': ['Addressing nicotine dependence is key to effective smoking cessation',
  'From among the global public health concerns, smoking remains one of the most crucial challenges',
  'A general problem with this type of investigation is that continuous nicotine application does not mimic the spike-wise application with cigarette smoking , and may lead to nicotine tolerance .',
  'A limitation of the cost-effectiveness analysis , shared with several previous cost-effectiveness analyses of smoking cessation interventions , is that intervention benefit is restricted to the first quit attempt .',
  'One problem with assessing effects of smoking cessation interventions on withdrawal symptoms is that symptoms are affected by whether participants abstain from smoking during trials .',
  'The rapid desensitization of alpha7 nicotinic acetylcholine receptors ( nAChR ) has presented a serious problem for the characterization of this receptor subtype , potentially confounding the interpretation of concentration-response relationships .',
  'In utero tobacco consumption is a serious public health problem in France ; it is very frequent and the long term consequences are not only numerous but also misinterpreted by our population .',
  'Menthol cigarette use remains a serious public health problem , prompting the consideration of tobacco regulatory efforts to ban menthol cigarettes .',
  '[ Traditional cigarette consumption among school-aged adolescents , a serious Public Health problem and effective prevention measures ] .',
  'Tobacco use among school children is becoming a serious problem in developing countries .',
  'The findings suggest that tobacco use is still a serious public health problem among Asian Americans , especially men .',
  'Smoking is a serious medical and social problem in Poland .',
  'Secondhand smoke exposure declined from 2010 to 2015 in China but remains a serious problem .',
  'Smoking is a serious public health problem around the world and causes many diseases such as chronic obstructive pulmonary disease , lung cancer , and some eye diseases .',
  'Smoking during pregnancy is a serious public health concern that poses risks for maternal and infant health .',
  'Smoking is a serious public health problem , and accurate real-time assessment of risk factors associated with smoking is critical to understanding smoking relapse .',
  "The smokers ' characteristics most commonly associated with misinformation when all six indices were combined into a summary index were as follows : those aged 45 years or older , smokers of ultralight cigarettes , smokers who believe they will stop smoking before they experience a serious health problem caused by smoking , smokers who have never used a stop-smoking medication , and smokers with a lower education level .",
  'Tobacco is the leading modifiable cause of cardiovascular disease , cancer , and respiratory diseases and is thus a serious global public health problem .',
  'The habit of smoking remains a severe public health problem .',
  'Tobacco use is a serious public health problem among Arab Americans with limited English proficiency .',
  'Use of tobacco is a serious public health problem in Indonesia that requires a multidisciplinary approach by healthcare providers to address it .',
  'Transnational tobacco companies ( TTCs ) have argued that tobacco-attributable deforestation is not a serious problem , and that the industry has addressed the issue through corporate social responsibility ( CSR ) initiatives .',
  'Cigarette smoking is a serious health problem in China , not only in adults but also in adolescents .',
  'Tobacco smoking among nursing students is a serious problem because of the public role model of these future healthcare professionals .',
  'Tobacco use remains a serious and persistent national problem .',
  'Tobacco addiction is a serious psychosocial and health problem .',
  'Smoking tobacco by soldiers is a serious health and social problem as its consequences may restrict their occupational efficiency .',
  'The effect of smoking is in our days a serious global public health problem of major concern .',
  'Although smoking behavior is a serious problem among Arab American immigrants in general and in the Arab world in particular , cultural factors that support healthy behavior during pregnancy in the Arab culture seem to limit the use of tobacco in pregnant women .',
  'Background Tobacco use is still a serious public health problem in the world and represents a major cause of morbidity and mortality in most parts of the world .',
  'Smoking prevalence remains high , particularly among adolescents and young adults with lower educational levels , posing a serious public health problem .',
  'Cigarette smoking is a serious health problem throughout the world , with a complicated and not totally clear bio-effect .',
  'Over the last decade notable progress has been made in developed countries on monitoring smoking although experimenting with cigarettes and smoking in young people remains a serious public health problem .',
  'Rising trend of female tobacco use is a serious concern in South East Asia Region .',
  'The use of nicotine through smoking remains a serious health problem .',
  'The use of spit tobacco ( ST ) products is a serious public health problem in the United States .',
  'The disposal and littering of cigarette butts ( CBs ) is a serious environmental problem .',
  'The prevalence of tobacco use among individuals with mental illness remains a serious public health concern .',
  'Exposure to secondhand smoke ( SHS ) is a serious global public health problem .',
  'Smoking is a serious problem in the South-eastern Anatolian Region .',
  'Smoking is widely recognized as a serious health problem .',
  'Tobacco use is a serious health concern in Albania .',
  'Electronic-cigarette ( e-cig ) vaping is a serious concern , as many pregnant women who vape consider it safe .',
  'Tobacco use among school children is becoming a serious problem in developing countries .',
  'An increase in hookah smoking is considered to be a serious health problem in societies withdifferent cigarette smoking patterns .',
  'Smoking -- a serious health problem in China .',
  'Smoking during pregnancy is a serious public health problem in need of better treatments .',
  'Particularly in groups of adolescents with lower educational level the smoking prevalence is still high and constitutes a serious public health problem .',
  'Tobacco smoking is a serious health problem worldwide and a leading cause of mortality .',
  'In Poland smoking poses a severe socioeconomic problem .',
  'Smoking is a serious global public health concern that has been related to many chronic diseases .',
  'Secondhand smoke ( SHS ) caused by smoking on apartment verandas is a severe social problem in Japan .',
  'Tobacco use by youth is a serious problem that can be handled by the combined attention of parents , youth advocates , health professional and youths themselves .',
  'Smoking is a serious public health problem and an important risk factor of many diseases .',
  'The results indicate that smoking is a serious problem in this population .',
  'Exposure to second-hand smoke ( SHS ) is a serious public health concern .',
  'However , despite the recent declines and intervention efforts , today smoking remains a serious problem among youth , with a quarter of adolescents being current smokers by the time they complete 12th grade .',
  'In conclusion , smoking is a serious problem after OLT and increases the risk for malignancy .',
  'Underage tobacco sales is considered a serious public health problem in Los Angeles .',
  'Despite decades of public education , cigarette smoking remains a serious health problem .',
  'Despite smoking cessation efforts , cigarette smoking remains a serious general and oral health problem .',
  'Tobacco addiction is a serious health and economic problem concerning the whole globe .',
  'Smoking , especially among adolescents , is considered a serious public health concern worldwide being associated with increased mortality .',
  'Cigarette smoking among low-income African Americans : a serious public health problem .',
  'Tobacco use is a serious public health problem among low-income Chinese Americans with limited English proficiency .',
  'Smoking is a serious problem in prisons .',
  'Because post-cessation weight gain may be a serious health threat for this population , but weight gain was not a concern for these smokers , smoking-cessation interventions for low-income African-American smokers may need to incorporate weight-gain education and prevention .',
  'Cigarette filters pose a serious litter and toxic waste disposal problem , because of their not biodegradability and to the leaching of toxins in the environment .',
  'Cigarette smoking is a serious health problem of our society .',
  'Smoking is still a serious economic , health , and social problem despite various efforts to curb its prevalence .',
  'Results suggest that smoking will continue as a serious problem among Thai males and demonstrate the addictive nature of cigarette smoking which persists in spite of the increasingly negative evaluative attitudes of users .',
  'Despite the increased awareness regarding the risks of cigarette smoking , this behavior continues to be a serious public health concern .',
  "Children 's exposure to secondhand smoke ( SHS ) is a severe public health problem .",
  'Nicotine addiction is a severe public health problem .',
  'Tobacco use is known as a serious global public health problem , and is also an important risk factor for oral diseases .',
  'Smoking is a serious worldwide public health problem .',
  'The smoking related respiratory diseases represent a serious medical , social , and economic problem .',
  'Nicotine addiction is a serious health problem resulting in millions of preventable deaths worldwide .',
  'Despite documented decreases in the prevalence of smoking in Canada , increases in flavoured tobacco use by its youth poses a serious public health concern .',
  'With almost one fifth of college-going youth smoking and a higher prevalence in older age groups within them , smoking is a serious concern for young people in Western Nepal .',
  'Second-hand smoke ( SHS ) in households remains a serious public health problem in Sri Lanka , partly due to a lack of voluntary prohibitions of tobacco smoking inside houses .',
  'Exposure to second-hand tobacco smoke is a serious public health concern and while all EU Member States have enacted some form of regulation aimed at limiting exposure , the scope of these regulations vary widely and many countries have failed to enact comprehensive legislation creating smoke-free workplaces and indoor public places .',
  "Smoking has been recognized as a serious medical problem since thefirst Surgeon General 's Report on Smoking and Health in 1964 .",
  'Tobacco consumption in Portugal remains a serious problem , particularly among young people .',
  'Our results clearly indicate that a large number of health care providers smoke which should be a serious concern . Hence our health agencies should take immediate action in order to curtail the heaving burden of smoking and its related health consequences .',
  'Nicotine addiction ( NA ) is a serious public health problem and helping patients to stop consumption is a major concern for general practitioners ( GP ) .',
  'Cigarette smoking is a serious problem among Greek youth .',
  'Among Arab citizens in Israel , cigarette and nargila ( hookah , waterpipe ) smoking is a serious public health problem , particularly among the young adult population .',
  'Adolescent tobacco use remains a serious problem , and adolescents may be particularly receptive to the glamorous images tobacco companies use in advertisements .',
  "Tobacco use , obesity , and physical inactivity among Louisiana 's youth pose a serious public health problem .",
  'Smoking in University of Chengdu , China is a severe problem .',
  'In the cohort , light-to-moderate smokers in the intervention communities came to have stronger beliefs about smoking as a serious public health problem .',
  'Nicotine Bound to Its Receptors : New Structures for a Vexing Pathopharmacological Problem .',
  'Active and passive tobacco exposure : a serious pediatric health problem .',
  'Tobacco use among school children is becoming a serious problem in developing countries .',
  'With the rapid increase in electronic cigarette ( e-cig ) users worldwide , secondhand exposure to e-cig aerosols has become a serious public health concern .',
  'Smoking is a serious public health problem worldwide .',
  'Tobacco smoking and its consequences are a serious public health problem in Romania .',
  'Smoking in Jordan is a serious problem as it affects almost all segments of society including children .',
  'Altogether this study emphasizes the importance of active smoking as a serious public health problem particularly for children and women .',
  'Tobacco use is a serious health problem in the USA , and this problem is potentiated in patients with schizophrenia .',
  'Nearly doubled average concentration of ExhCO among passive smoking mothers in comparison to the non-smoking ones arises a serious concern .',
  'The results of the study suggest that regular exposure to secondhand smoke becomes a serious problem .',
  'Smoking is a serious public health concern , particularly among young people .',
  'The use of contraband cigarettes is a serious public health problem .',
  'This study uses conversation analysis to explicate how patients and doctors manage issues of responsibility in smoking cessation discussions in the face of a serious medical problem that strongly correlates with smoking .',
  'China is facing a serious public health problem in active and passive smokers .',
  'Cigarette , alcohol and substance use is a worldwide threat which especially affects young people and a preventable public health problem .',
  'Active and passive tobacco exposure : a serious pediatric health problem .',
  'The smoking represents a serious problem of public health .',
  'The habit of tobacco use/smoking , which is a major concern of Primary Health Care ( PHC ) , is a serious public health problem and the main avoidable cause of death in the world .',
  'Over the last decade , there has been a major decline in the prevalence of smoking among Western populations whilst in most developing countries there is a serious health problem of increasing smoking prevalence , especially among young age groups .',
  'Tobacco use was rated as a serious problem for Guam by 73 % of the leaders surveyed , and a majority agreed that stricter tobacco control policies were needed on Guam .',
  'Nicotine addiction is a serious public health problem causing millions of deaths worldwide .',
  'During cigarette manufacturing large quantities of tobacco waste are produced annually and its disposal is a serious ecological problem .',
  'African Americans favored tobacco restrictions ( they were 1.8 times more likely than Whites to view smoking as a serious community problem , 1.7 times more likely to favor restrictions on cigarette vending machines , and 2.1 times more likely to prohibit smoking in their car ) .',
  'Smoking is a serious public health problem .',
  'Smoking is a serious public health problem .',
  "Thai adolescent 's access to tobacco continues to be a serious public health problem .",
  'Nicotine dependence is a serious public health concern .',
  'Background Electronic cigarette or vaping product use-associated lung injury ( EVALI ) is a serious public health concern with substantial morbidity and mortality , particularly in young individuals .',
  'Tobacco dependence is a serious public health concern .',
  'Smoking represents a serious worldwide public health problem because of its close association with the development of chronic disease and cancer .',
  'The Cigarette and the Sperm : A Fatal Liaison ? Eur Urol 2016;70:646 - 7 : The Cigarette and the Sperm : Causality Dilemma no more ?',
  'Waterpipe smoking is a global health problem and a serious public concern .',
  'Tobacco use is a serious public health problem in the South East Asia Region where use of both smoking and smokeless form of tobacco is widely prevalent .',
  'Results suggest that although the Chinese Ministry of Education ( MOE ) encourages smoke-free schools , experimentation with cigarettes remains a serious problem among primary school students in China .',
  'Tobacco use among school children is becoming a serious problem .',
  'Ex-smokers view smoking as a serious health problem , did not report having a physician recommend they stop , and feel personally susceptible to its adverse effects .',
  'Tobacco use is a serious public health concern as it causes various deleterious health problems .',
  'Nonsmokers also regarded smoking as a serious problem to the organizational climate of workplaces .',
  'A serious health problem was an appropriate reason to quit but older women continued to smoke despite serious health problems .',
  'Smoking is a serious problem for the health care system .',
  'Smoking tobacco by the public service workers is a serious health and social problem as its consequences may restrict their efficiency .',
  'Smoking is now a serious social problem in Poland and abroad .',
  'Tobacco smoking is a serious health and social problem .',
  'Smoking is known as a serious global public health problem , and is also an important risk factor for oral diseases and cause of oxidative stress and cellular damage .',
  'Second hand smoke ( SHS ) exposure is a severe public health problem , especially in low and middle countries , but no studies have examined both individual and city-level variables influencing exposure .',
  'Contributing factors : smoking is an important trigger and a serious problem in most Asian-Pacific countries .',
  'Cigarette smoking remains a serious public health problem .',
  'The effects of ETS on human health are well-known , passive smoking is harmful to those who breathe the toxins and it is a serious problem for public health .',
  'Tobacco non-users exposed to the campaign were 1.5 times more likely to help someone quit using tobacco than those not exposed , report that tobacco is a serious problem in Oklahoma , believe that tobacco companies should not be allowed to give away free samples or advertise at public events , and believe that smoking should be banned at public outdoor places .',
  'The study confirms a serious public health problem in both countries , and documents that environmental exposure persists in subgroups of women , even in those who quit smoking .',
  'Tobacco-attributable hospitalisations pose a serious but preventable problem for the health care system .',
  'On the basis of the evidence presented in this paper , there is a serious concern the tobacco industry may have been unduly influential on the content of the journal .',
  'A third cause of market failure , market power , is also a serious problem in many tobacco markets .',
  'Tobacco smoking prevalence continues to be high , particularly among adolescents and young adults with lower educational levels , and is therefore a serious public health problem .',
  'Shisha smoking is a serious problem among university students .',
  'Even though it is diminishing in Europe , smoking is still a serious health problem .',
  'Secondhand smoke ( SHS ) , a common environmental exposure factor , has become a serious public health problem .',
  'Craving remains a clinically relevant phenomenon , with most smokers describing craving as a troublesome problem when quitting .',
  'Smokeless tobacco is a serious problem in American colleges and universities .'],
 'tobacco': ['Addressing nicotine dependence is key to effective smoking cessation',
  'From among the global public health concerns, smoking remains one of the most crucial challenges',
  'A general problem with this type of investigation is that continuous nicotine application does not mimic the spike-wise application with cigarette smoking , and may lead to nicotine tolerance .',
  'A limitation of the cost-effectiveness analysis , shared with several previous cost-effectiveness analyses of smoking cessation interventions , is that intervention benefit is restricted to the first quit attempt .',
  'One problem with assessing effects of smoking cessation interventions on withdrawal symptoms is that symptoms are affected by whether participants abstain from smoking during trials .',
  'The rapid desensitization of alpha7 nicotinic acetylcholine receptors ( nAChR ) has presented a serious problem for the characterization of this receptor subtype , potentially confounding the interpretation of concentration-response relationships .',
  'In utero tobacco consumption is a serious public health problem in France ; it is very frequent and the long term consequences are not only numerous but also misinterpreted by our population .',
  'Menthol cigarette use remains a serious public health problem , prompting the consideration of tobacco regulatory efforts to ban menthol cigarettes .',
  '[ Traditional cigarette consumption among school-aged adolescents , a serious Public Health problem and effective prevention measures ] .',
  'Tobacco use among school children is becoming a serious problem in developing countries .',
  'The findings suggest that tobacco use is still a serious public health problem among Asian Americans , especially men .',
  'Smoking is a serious medical and social problem in Poland .',
  'Secondhand smoke exposure declined from 2010 to 2015 in China but remains a serious problem .',
  'Smoking is a serious public health problem around the world and causes many diseases such as chronic obstructive pulmonary disease , lung cancer , and some eye diseases .',
  'Smoking during pregnancy is a serious public health concern that poses risks for maternal and infant health .',
  'Smoking is a serious public health problem , and accurate real-time assessment of risk factors associated with smoking is critical to understanding smoking relapse .',
  "The smokers ' characteristics most commonly associated with misinformation when all six indices were combined into a summary index were as follows : those aged 45 years or older , smokers of ultralight cigarettes , smokers who believe they will stop smoking before they experience a serious health problem caused by smoking , smokers who have never used a stop-smoking medication , and smokers with a lower education level .",
  'Tobacco is the leading modifiable cause of cardiovascular disease , cancer , and respiratory diseases and is thus a serious global public health problem .',
  'The habit of smoking remains a severe public health problem .',
  'Tobacco use is a serious public health problem among Arab Americans with limited English proficiency .',
  'Use of tobacco is a serious public health problem in Indonesia that requires a multidisciplinary approach by healthcare providers to address it .',
  'Transnational tobacco companies ( TTCs ) have argued that tobacco-attributable deforestation is not a serious problem , and that the industry has addressed the issue through corporate social responsibility ( CSR ) initiatives .',
  'Cigarette smoking is a serious health problem in China , not only in adults but also in adolescents .',
  'Tobacco smoking among nursing students is a serious problem because of the public role model of these future healthcare professionals .',
  'Tobacco use remains a serious and persistent national problem .',
  'Tobacco addiction is a serious psychosocial and health problem .',
  'Smoking tobacco by soldiers is a serious health and social problem as its consequences may restrict their occupational efficiency .',
  'The effect of smoking is in our days a serious global public health problem of major concern .',
  'Although smoking behavior is a serious problem among Arab American immigrants in general and in the Arab world in particular , cultural factors that support healthy behavior during pregnancy in the Arab culture seem to limit the use of tobacco in pregnant women .',
  'Background Tobacco use is still a serious public health problem in the world and represents a major cause of morbidity and mortality in most parts of the world .',
  'Smoking prevalence remains high , particularly among adolescents and young adults with lower educational levels , posing a serious public health problem .',
  'Cigarette smoking is a serious health problem throughout the world , with a complicated and not totally clear bio-effect .',
  'Over the last decade notable progress has been made in developed countries on monitoring smoking although experimenting with cigarettes and smoking in young people remains a serious public health problem .',
  'Rising trend of female tobacco use is a serious concern in South East Asia Region .',
  'The use of nicotine through smoking remains a serious health problem .',
  'The use of spit tobacco ( ST ) products is a serious public health problem in the United States .',
  'The disposal and littering of cigarette butts ( CBs ) is a serious environmental problem .',
  'The prevalence of tobacco use among individuals with mental illness remains a serious public health concern .',
  'Exposure to secondhand smoke ( SHS ) is a serious global public health problem .',
  'Smoking is a serious problem in the South-eastern Anatolian Region .',
  'Smoking is widely recognized as a serious health problem .',
  'Tobacco use is a serious health concern in Albania .',
  'Electronic-cigarette ( e-cig ) vaping is a serious concern , as many pregnant women who vape consider it safe .',
  'Tobacco use among school children is becoming a serious problem in developing countries .',
  'An increase in hookah smoking is considered to be a serious health problem in societies withdifferent cigarette smoking patterns .',
  'Smoking -- a serious health problem in China .',
  'Smoking during pregnancy is a serious public health problem in need of better treatments .',
  'Particularly in groups of adolescents with lower educational level the smoking prevalence is still high and constitutes a serious public health problem .',
  'Tobacco smoking is a serious health problem worldwide and a leading cause of mortality .',
  'In Poland smoking poses a severe socioeconomic problem .',
  'Smoking is a serious global public health concern that has been related to many chronic diseases .',
  'Secondhand smoke ( SHS ) caused by smoking on apartment verandas is a severe social problem in Japan .',
  'Tobacco use by youth is a serious problem that can be handled by the combined attention of parents , youth advocates , health professional and youths themselves .',
  'Smoking is a serious public health problem and an important risk factor of many diseases .',
  'The results indicate that smoking is a serious problem in this population .',
  'Exposure to second-hand smoke ( SHS ) is a serious public health concern .',
  'However , despite the recent declines and intervention efforts , today smoking remains a serious problem among youth , with a quarter of adolescents being current smokers by the time they complete 12th grade .',
  'In conclusion , smoking is a serious problem after OLT and increases the risk for malignancy .',
  'Underage tobacco sales is considered a serious public health problem in Los Angeles .',
  'Despite decades of public education , cigarette smoking remains a serious health problem .',
  'Despite smoking cessation efforts , cigarette smoking remains a serious general and oral health problem .',
  'Tobacco addiction is a serious health and economic problem concerning the whole globe .',
  'Smoking , especially among adolescents , is considered a serious public health concern worldwide being associated with increased mortality .',
  'Cigarette smoking among low-income African Americans : a serious public health problem .',
  'Tobacco use is a serious public health problem among low-income Chinese Americans with limited English proficiency .',
  'Smoking is a serious problem in prisons .',
  'Because post-cessation weight gain may be a serious health threat for this population , but weight gain was not a concern for these smokers , smoking-cessation interventions for low-income African-American smokers may need to incorporate weight-gain education and prevention .',
  'Cigarette filters pose a serious litter and toxic waste disposal problem , because of their not biodegradability and to the leaching of toxins in the environment .',
  'Cigarette smoking is a serious health problem of our society .',
  'Smoking is still a serious economic , health , and social problem despite various efforts to curb its prevalence .',
  'Results suggest that smoking will continue as a serious problem among Thai males and demonstrate the addictive nature of cigarette smoking which persists in spite of the increasingly negative evaluative attitudes of users .',
  'Despite the increased awareness regarding the risks of cigarette smoking , this behavior continues to be a serious public health concern .',
  "Children 's exposure to secondhand smoke ( SHS ) is a severe public health problem .",
  'Nicotine addiction is a severe public health problem .',
  'Tobacco use is known as a serious global public health problem , and is also an important risk factor for oral diseases .',
  'Smoking is a serious worldwide public health problem .',
  'The smoking related respiratory diseases represent a serious medical , social , and economic problem .',
  'Nicotine addiction is a serious health problem resulting in millions of preventable deaths worldwide .',
  'Despite documented decreases in the prevalence of smoking in Canada , increases in flavoured tobacco use by its youth poses a serious public health concern .',
  'With almost one fifth of college-going youth smoking and a higher prevalence in older age groups within them , smoking is a serious concern for young people in Western Nepal .',
  'Second-hand smoke ( SHS ) in households remains a serious public health problem in Sri Lanka , partly due to a lack of voluntary prohibitions of tobacco smoking inside houses .',
  'Exposure to second-hand tobacco smoke is a serious public health concern and while all EU Member States have enacted some form of regulation aimed at limiting exposure , the scope of these regulations vary widely and many countries have failed to enact comprehensive legislation creating smoke-free workplaces and indoor public places .',
  "Smoking has been recognized as a serious medical problem since thefirst Surgeon General 's Report on Smoking and Health in 1964 .",
  'Tobacco consumption in Portugal remains a serious problem , particularly among young people .',
  'Our results clearly indicate that a large number of health care providers smoke which should be a serious concern . Hence our health agencies should take immediate action in order to curtail the heaving burden of smoking and its related health consequences .',
  'Nicotine addiction ( NA ) is a serious public health problem and helping patients to stop consumption is a major concern for general practitioners ( GP ) .',
  'Cigarette smoking is a serious problem among Greek youth .',
  'Among Arab citizens in Israel , cigarette and nargila ( hookah , waterpipe ) smoking is a serious public health problem , particularly among the young adult population .',
  'Adolescent tobacco use remains a serious problem , and adolescents may be particularly receptive to the glamorous images tobacco companies use in advertisements .',
  "Tobacco use , obesity , and physical inactivity among Louisiana 's youth pose a serious public health problem .",
  'Smoking in University of Chengdu , China is a severe problem .',
  'In the cohort , light-to-moderate smokers in the intervention communities came to have stronger beliefs about smoking as a serious public health problem .',
  'Nicotine Bound to Its Receptors : New Structures for a Vexing Pathopharmacological Problem .',
  'Active and passive tobacco exposure : a serious pediatric health problem .',
  'Tobacco use among school children is becoming a serious problem in developing countries .',
  'With the rapid increase in electronic cigarette ( e-cig ) users worldwide , secondhand exposure to e-cig aerosols has become a serious public health concern .',
  'Smoking is a serious public health problem worldwide .',
  'Tobacco smoking and its consequences are a serious public health problem in Romania .',
  'Smoking in Jordan is a serious problem as it affects almost all segments of society including children .',
  'Altogether this study emphasizes the importance of active smoking as a serious public health problem particularly for children and women .',
  'Tobacco use is a serious health problem in the USA , and this problem is potentiated in patients with schizophrenia .',
  'Nearly doubled average concentration of ExhCO among passive smoking mothers in comparison to the non-smoking ones arises a serious concern .',
  'The results of the study suggest that regular exposure to secondhand smoke becomes a serious problem .',
  'Smoking is a serious public health concern , particularly among young people .',
  'The use of contraband cigarettes is a serious public health problem .',
  'This study uses conversation analysis to explicate how patients and doctors manage issues of responsibility in smoking cessation discussions in the face of a serious medical problem that strongly correlates with smoking .',
  'China is facing a serious public health problem in active and passive smokers .',
  'Cigarette , alcohol and substance use is a worldwide threat which especially affects young people and a preventable public health problem .',
  'Active and passive tobacco exposure : a serious pediatric health problem .',
  'The smoking represents a serious problem of public health .',
  'The habit of tobacco use/smoking , which is a major concern of Primary Health Care ( PHC ) , is a serious public health problem and the main avoidable cause of death in the world .',
  'Over the last decade , there has been a major decline in the prevalence of smoking among Western populations whilst in most developing countries there is a serious health problem of increasing smoking prevalence , especially among young age groups .',
  'Tobacco use was rated as a serious problem for Guam by 73 % of the leaders surveyed , and a majority agreed that stricter tobacco control policies were needed on Guam .',
  'Nicotine addiction is a serious public health problem causing millions of deaths worldwide .',
  'During cigarette manufacturing large quantities of tobacco waste are produced annually and its disposal is a serious ecological problem .',
  'African Americans favored tobacco restrictions ( they were 1.8 times more likely than Whites to view smoking as a serious community problem , 1.7 times more likely to favor restrictions on cigarette vending machines , and 2.1 times more likely to prohibit smoking in their car ) .',
  'Smoking is a serious public health problem .',
  'Smoking is a serious public health problem .',
  "Thai adolescent 's access to tobacco continues to be a serious public health problem .",
  'Nicotine dependence is a serious public health concern .',
  'Background Electronic cigarette or vaping product use-associated lung injury ( EVALI ) is a serious public health concern with substantial morbidity and mortality , particularly in young individuals .',
  'Tobacco dependence is a serious public health concern .',
  'Smoking represents a serious worldwide public health problem because of its close association with the development of chronic disease and cancer .',
  'The Cigarette and the Sperm : A Fatal Liaison ? Eur Urol 2016;70:646 - 7 : The Cigarette and the Sperm : Causality Dilemma no more ?',
  'Waterpipe smoking is a global health problem and a serious public concern .',
  'Tobacco use is a serious public health problem in the South East Asia Region where use of both smoking and smokeless form of tobacco is widely prevalent .',
  'Results suggest that although the Chinese Ministry of Education ( MOE ) encourages smoke-free schools , experimentation with cigarettes remains a serious problem among primary school students in China .',
  'Tobacco use among school children is becoming a serious problem .',
  'Ex-smokers view smoking as a serious health problem , did not report having a physician recommend they stop , and feel personally susceptible to its adverse effects .',
  'Tobacco use is a serious public health concern as it causes various deleterious health problems .',
  'Nonsmokers also regarded smoking as a serious problem to the organizational climate of workplaces .',
  'A serious health problem was an appropriate reason to quit but older women continued to smoke despite serious health problems .',
  'Smoking is a serious problem for the health care system .',
  'Smoking tobacco by the public service workers is a serious health and social problem as its consequences may restrict their efficiency .',
  'Smoking is now a serious social problem in Poland and abroad .',
  'Tobacco smoking is a serious health and social problem .',
  'Smoking is known as a serious global public health problem , and is also an important risk factor for oral diseases and cause of oxidative stress and cellular damage .',
  'Second hand smoke ( SHS ) exposure is a severe public health problem , especially in low and middle countries , but no studies have examined both individual and city-level variables influencing exposure .',
  'Contributing factors : smoking is an important trigger and a serious problem in most Asian-Pacific countries .',
  'Cigarette smoking remains a serious public health problem .',
  'The effects of ETS on human health are well-known , passive smoking is harmful to those who breathe the toxins and it is a serious problem for public health .',
  'Tobacco non-users exposed to the campaign were 1.5 times more likely to help someone quit using tobacco than those not exposed , report that tobacco is a serious problem in Oklahoma , believe that tobacco companies should not be allowed to give away free samples or advertise at public events , and believe that smoking should be banned at public outdoor places .',
  'The study confirms a serious public health problem in both countries , and documents that environmental exposure persists in subgroups of women , even in those who quit smoking .',
  'Tobacco-attributable hospitalisations pose a serious but preventable problem for the health care system .',
  'On the basis of the evidence presented in this paper , there is a serious concern the tobacco industry may have been unduly influential on the content of the journal .',
  'A third cause of market failure , market power , is also a serious problem in many tobacco markets .',
  'Tobacco smoking prevalence continues to be high , particularly among adolescents and young adults with lower educational levels , and is therefore a serious public health problem .',
  'Shisha smoking is a serious problem among university students .',
  'Even though it is diminishing in Europe , smoking is still a serious health problem .',
  'Secondhand smoke ( SHS ) , a common environmental exposure factor , has become a serious public health problem .',
  'Craving remains a clinically relevant phenomenon , with most smokers describing craving as a troublesome problem when quitting .',
  'Smokeless tobacco is a serious problem in American colleges and universities .'],
 'fistula': ['Obstetric fistula is a maternal morbidity creating devastating health problems for the women',
  'Nontraumatic atrial-esophageal fistula is a catastrophic problem usually diagnosed postmortem and almost invariably fatal .',
  'Constant urinary leakage is a serious social and physical problem accompanying a vesicovaginal fistula in curable and incurable patients .',
  'Vesicovaginal fistula ( VVF ) is a devastating social problem .',
  'Duodenal fistula ( DF ) after gastrectomy continues to be a life-threatening problem .',
  'Tracheomediastinal fistulas are very rare but can be a serious problem .',
  'Rectovaginal fistulas present a distressing problem for the patient and a challenge for the treating physician .',
  "An ileosigmoid fistula complicating Crohn 's disease of the small bowel has been considered a perplexing entity , but in practice does not pose a serious operative problem .",
  'Postoperative salivary fistulas still remain a serious and potentially lethal problem in head and neck reconstruction particularly if the fistula is large and involving one half or more of the circumference of the pharyngo-oesophagus .',
  'CONCLUSIONS We suggest that cholecysto-hydatid fistula is a severe problem that requires close workup with both the radiology and surgery departments .',
  'Yet , digestive system fistula as a serious complication still poses a very difficult surgical problem .',
  'External duodenal fistula continues to be a life-threatening problem whether it is postoperative , posttraumatic , or secondary to a disease process .',
  'However , management of high fistulas has long been a serious problem because of the necessity of preserving at least some of the sphincter mechanism .',
  'Bronchopleural cutaneous fistulas are a serious problem that are difficult to treat with any assurance of success .',
  'BACKGROUND Abdominal bleeding is a severe complication of duodenal fistula , but few studies have focused on this problem .',
  'Although fistulae resulting from superficial parotidectomy represent a serious problem , there is still little consensus on the optimal treatment .',
  'Pulmonary arteriovenous fistulas are a serious concern , especially in young patients with heterotaxy syndrome .',
  'Obstetric fistula is a serious public health problem affecting women in low- and middle-income countries .',
  'Such fistulae may not be a life-threatening problem , but surely the women face demoralization , social boycott and even divorce and separation .',
  'Aortoenteric fistulas : a preventable problem ?',
  'Enterocutaneous fistula continues to be a serious surgical problem .',
  'Vesicovaginal fistula continues to be a distressing problem that results most commonly from urogynecologic surgery .',
  'Genitourinary fistulas are a debilitating problem in females but a comprehensive approach regarding diagnosis and treatment can cure these patients .',
  'Rectovaginal fistulae ( RVF ) are a serious and debilitating problem for patients and a challenge for the treating surgeons .',
  'Rectovaginal fistuale ( RVF ) are a serious and disabling problem for the patients and a surgical challenge for the treating physicians .'],
 'fistulas': ['Obstetric fistula is a maternal morbidity creating devastating health problems for the women',
  'Nontraumatic atrial-esophageal fistula is a catastrophic problem usually diagnosed postmortem and almost invariably fatal .',
  'Constant urinary leakage is a serious social and physical problem accompanying a vesicovaginal fistula in curable and incurable patients .',
  'Vesicovaginal fistula ( VVF ) is a devastating social problem .',
  'Duodenal fistula ( DF ) after gastrectomy continues to be a life-threatening problem .',
  'Tracheomediastinal fistulas are very rare but can be a serious problem .',
  'Rectovaginal fistulas present a distressing problem for the patient and a challenge for the treating physician .',
  "An ileosigmoid fistula complicating Crohn 's disease of the small bowel has been considered a perplexing entity , but in practice does not pose a serious operative problem .",
  'Postoperative salivary fistulas still remain a serious and potentially lethal problem in head and neck reconstruction particularly if the fistula is large and involving one half or more of the circumference of the pharyngo-oesophagus .',
  'CONCLUSIONS We suggest that cholecysto-hydatid fistula is a severe problem that requires close workup with both the radiology and surgery departments .',
  'Yet , digestive system fistula as a serious complication still poses a very difficult surgical problem .',
  'External duodenal fistula continues to be a life-threatening problem whether it is postoperative , posttraumatic , or secondary to a disease process .',
  'However , management of high fistulas has long been a serious problem because of the necessity of preserving at least some of the sphincter mechanism .',
  'Bronchopleural cutaneous fistulas are a serious problem that are difficult to treat with any assurance of success .',
  'BACKGROUND Abdominal bleeding is a severe complication of duodenal fistula , but few studies have focused on this problem .',
  'Although fistulae resulting from superficial parotidectomy represent a serious problem , there is still little consensus on the optimal treatment .',
  'Pulmonary arteriovenous fistulas are a serious concern , especially in young patients with heterotaxy syndrome .',
  'Obstetric fistula is a serious public health problem affecting women in low- and middle-income countries .',
  'Such fistulae may not be a life-threatening problem , but surely the women face demoralization , social boycott and even divorce and separation .',
  'Aortoenteric fistulas : a preventable problem ?',
  'Enterocutaneous fistula continues to be a serious surgical problem .',
  'Vesicovaginal fistula continues to be a distressing problem that results most commonly from urogynecologic surgery .',
  'Genitourinary fistulas are a debilitating problem in females but a comprehensive approach regarding diagnosis and treatment can cure these patients .',
  'Rectovaginal fistulae ( RVF ) are a serious and debilitating problem for patients and a challenge for the treating surgeons .',
  'Rectovaginal fistuale ( RVF ) are a serious and disabling problem for the patients and a surgical challenge for the treating physicians .'],
 'fistulae': ['Obstetric fistula is a maternal morbidity creating devastating health problems for the women',
  'Nontraumatic atrial-esophageal fistula is a catastrophic problem usually diagnosed postmortem and almost invariably fatal .',
  'Constant urinary leakage is a serious social and physical problem accompanying a vesicovaginal fistula in curable and incurable patients .',
  'Vesicovaginal fistula ( VVF ) is a devastating social problem .',
  'Duodenal fistula ( DF ) after gastrectomy continues to be a life-threatening problem .',
  'Tracheomediastinal fistulas are very rare but can be a serious problem .',
  'Rectovaginal fistulas present a distressing problem for the patient and a challenge for the treating physician .',
  "An ileosigmoid fistula complicating Crohn 's disease of the small bowel has been considered a perplexing entity , but in practice does not pose a serious operative problem .",
  'Postoperative salivary fistulas still remain a serious and potentially lethal problem in head and neck reconstruction particularly if the fistula is large and involving one half or more of the circumference of the pharyngo-oesophagus .',
  'CONCLUSIONS We suggest that cholecysto-hydatid fistula is a severe problem that requires close workup with both the radiology and surgery departments .',
  'Yet , digestive system fistula as a serious complication still poses a very difficult surgical problem .',
  'External duodenal fistula continues to be a life-threatening problem whether it is postoperative , posttraumatic , or secondary to a disease process .',
  'However , management of high fistulas has long been a serious problem because of the necessity of preserving at least some of the sphincter mechanism .',
  'Bronchopleural cutaneous fistulas are a serious problem that are difficult to treat with any assurance of success .',
  'BACKGROUND Abdominal bleeding is a severe complication of duodenal fistula , but few studies have focused on this problem .',
  'Although fistulae resulting from superficial parotidectomy represent a serious problem , there is still little consensus on the optimal treatment .',
  'Pulmonary arteriovenous fistulas are a serious concern , especially in young patients with heterotaxy syndrome .',
  'Obstetric fistula is a serious public health problem affecting women in low- and middle-income countries .',
  'Such fistulae may not be a life-threatening problem , but surely the women face demoralization , social boycott and even divorce and separation .',
  'Aortoenteric fistulas : a preventable problem ?',
  'Enterocutaneous fistula continues to be a serious surgical problem .',
  'Vesicovaginal fistula continues to be a distressing problem that results most commonly from urogynecologic surgery .',
  'Genitourinary fistulas are a debilitating problem in females but a comprehensive approach regarding diagnosis and treatment can cure these patients .',
  'Rectovaginal fistulae ( RVF ) are a serious and debilitating problem for patients and a challenge for the treating surgeons .',
  'Rectovaginal fistuale ( RVF ) are a serious and disabling problem for the patients and a surgical challenge for the treating physicians .'],
 'vesicovaginal': ['Obstetric fistula is a maternal morbidity creating devastating health problems for the women',
  'Nontraumatic atrial-esophageal fistula is a catastrophic problem usually diagnosed postmortem and almost invariably fatal .',
  'Constant urinary leakage is a serious social and physical problem accompanying a vesicovaginal fistula in curable and incurable patients .',
  'Vesicovaginal fistula ( VVF ) is a devastating social problem .',
  'Duodenal fistula ( DF ) after gastrectomy continues to be a life-threatening problem .',
  'Tracheomediastinal fistulas are very rare but can be a serious problem .',
  'Rectovaginal fistulas present a distressing problem for the patient and a challenge for the treating physician .',
  "An ileosigmoid fistula complicating Crohn 's disease of the small bowel has been considered a perplexing entity , but in practice does not pose a serious operative problem .",
  'Postoperative salivary fistulas still remain a serious and potentially lethal problem in head and neck reconstruction particularly if the fistula is large and involving one half or more of the circumference of the pharyngo-oesophagus .',
  'CONCLUSIONS We suggest that cholecysto-hydatid fistula is a severe problem that requires close workup with both the radiology and surgery departments .',
  'Yet , digestive system fistula as a serious complication still poses a very difficult surgical problem .',
  'External duodenal fistula continues to be a life-threatening problem whether it is postoperative , posttraumatic , or secondary to a disease process .',
  'However , management of high fistulas has long been a serious problem because of the necessity of preserving at least some of the sphincter mechanism .',
  'Bronchopleural cutaneous fistulas are a serious problem that are difficult to treat with any assurance of success .',
  'BACKGROUND Abdominal bleeding is a severe complication of duodenal fistula , but few studies have focused on this problem .',
  'Although fistulae resulting from superficial parotidectomy represent a serious problem , there is still little consensus on the optimal treatment .',
  'Pulmonary arteriovenous fistulas are a serious concern , especially in young patients with heterotaxy syndrome .',
  'Obstetric fistula is a serious public health problem affecting women in low- and middle-income countries .',
  'Such fistulae may not be a life-threatening problem , but surely the women face demoralization , social boycott and even divorce and separation .',
  'Aortoenteric fistulas : a preventable problem ?',
  'Enterocutaneous fistula continues to be a serious surgical problem .',
  'Vesicovaginal fistula continues to be a distressing problem that results most commonly from urogynecologic surgery .',
  'Genitourinary fistulas are a debilitating problem in females but a comprehensive approach regarding diagnosis and treatment can cure these patients .',
  'Rectovaginal fistulae ( RVF ) are a serious and debilitating problem for patients and a challenge for the treating surgeons .',
  'Rectovaginal fistuale ( RVF ) are a serious and disabling problem for the patients and a surgical challenge for the treating physicians .'],
 'duodenal': ['Obstetric fistula is a maternal morbidity creating devastating health problems for the women',
  'Nontraumatic atrial-esophageal fistula is a catastrophic problem usually diagnosed postmortem and almost invariably fatal .',
  'Constant urinary leakage is a serious social and physical problem accompanying a vesicovaginal fistula in curable and incurable patients .',
  'Vesicovaginal fistula ( VVF ) is a devastating social problem .',
  'Duodenal fistula ( DF ) after gastrectomy continues to be a life-threatening problem .',
  'Tracheomediastinal fistulas are very rare but can be a serious problem .',
  'Rectovaginal fistulas present a distressing problem for the patient and a challenge for the treating physician .',
  "An ileosigmoid fistula complicating Crohn 's disease of the small bowel has been considered a perplexing entity , but in practice does not pose a serious operative problem .",
  'Postoperative salivary fistulas still remain a serious and potentially lethal problem in head and neck reconstruction particularly if the fistula is large and involving one half or more of the circumference of the pharyngo-oesophagus .',
  'CONCLUSIONS We suggest that cholecysto-hydatid fistula is a severe problem that requires close workup with both the radiology and surgery departments .',
  'Yet , digestive system fistula as a serious complication still poses a very difficult surgical problem .',
  'External duodenal fistula continues to be a life-threatening problem whether it is postoperative , posttraumatic , or secondary to a disease process .',
  'However , management of high fistulas has long been a serious problem because of the necessity of preserving at least some of the sphincter mechanism .',
  'Bronchopleural cutaneous fistulas are a serious problem that are difficult to treat with any assurance of success .',
  'BACKGROUND Abdominal bleeding is a severe complication of duodenal fistula , but few studies have focused on this problem .',
  'Although fistulae resulting from superficial parotidectomy represent a serious problem , there is still little consensus on the optimal treatment .',
  'Pulmonary arteriovenous fistulas are a serious concern , especially in young patients with heterotaxy syndrome .',
  'Obstetric fistula is a serious public health problem affecting women in low- and middle-income countries .',
  'Such fistulae may not be a life-threatening problem , but surely the women face demoralization , social boycott and even divorce and separation .',
  'Aortoenteric fistulas : a preventable problem ?',
  'Enterocutaneous fistula continues to be a serious surgical problem .',
  'Vesicovaginal fistula continues to be a distressing problem that results most commonly from urogynecologic surgery .',
  'Genitourinary fistulas are a debilitating problem in females but a comprehensive approach regarding diagnosis and treatment can cure these patients .',
  'Rectovaginal fistulae ( RVF ) are a serious and debilitating problem for patients and a challenge for the treating surgeons .',
  'Rectovaginal fistuale ( RVF ) are a serious and disabling problem for the patients and a surgical challenge for the treating physicians .'],
 'arthroplasty': ['\u2002Chronic osteomyelitis is a major challenge in orthopaedic surgery; it is the result of open fracture, periprosthetic infection and septic arthritis',
  'Infections of proximal femora with prosthetic implants in situ have long been a major concern in orthopedic surgery',
  'Infection of an expanded polytetrafluoroethylene ( ePTFE ) prosthesis after implant is a major drawback of its use in current clinical practice .',
  'Prosthetic infection is a serious concern for all arthroplasty surgeons .',
  'Postoperative infections in prosthetic surgery still constitute a serious problem , and one that is difficult to treat , because of the occurrence of agglomerates of microbes that are resistant to immune defenses and antibiotics .',
  'Resistant staphylococcal organisms remain a serious problem in the treatment of periprosthetic joint infection ( PJI ) .',
  'Periprosthetic infections remain a devastating problem in the field of joint arthroplasty .',
  'Infection remains a serious medical problem in orthopaedic surgery .',
  'Although the incidence of deep sepsis following total joint arthroplasty is lower than initially feared , it remains a serious problem for both the patient and the surgeon .',
  'Osteomyelitis in patients undergoing surgery because of injuries and diseases of the musculoskeletal system is a serious clinical , economic and social problem .',
  'Post-arthroplasty infections are a devastating problem in orthopaedic surgery .',
  'Infection after artificial joint replacement is a serious problem , which requires the re-implantation of prosthesis .',
  'Bone related-bacterial diseases including wound infections and osteomyelitis ( OM ) remain a serious problem accompanied with amputation in most severe cases .',
  'Prosthetic joint infection ( PJI ) is a severe complication for patients and represents an increasing health problem .',
  'Prosthetic joints infection is a serious medical , social and financial problem .',
  'The incidence of early deep infection after arthroplasty of the knee is very low but could represent a serious future problem .',
  'Antimicrobial resistance is a serious problem in orthopedics .',
  'Periprosthetic joint infection ( PJI ) continues to be a devastating problem in the field of total joint arthroplasty , and recent literature can be used to make the preoperative diagnosis of PJI , guide nonsurgical and surgical treatment , and provide postoperative antimicrobial management of PJI patients .',
  'Acute prosthetic infection is a serious problem .',
  'Infections with multiresistant bacteria have become a serious problem in joint arthroplasty .',
  'Periprosthetic joint infection ( PJI ) as an insurmountable challenge has always represented a serious concern for orthopedic surgeons .',
  'Infection remains a serious devastating problem for shoulder arthroplasty with an important functional impact .',
  'Methicillin-resistant Staphylococcus remains a serious problem in the treatment of periprosthetic joint infection ( PJI ) .',
  'Infections of the musculoskeletal system present a serious problem in orthopaedic and trauma medicine because , typically , they are often recurrent and associated with the development of resistance to antibiotics .',
  'Prosthetic joint infection ( PJI ) is a devastating complication in total knee arthroplasty ( TKA ) and third most common cause of revision of TKA with significant morbidity and surgical challenges .',
  'Infected nonunions resulting in segmental bone loss are a devastating complication for patients and a difficult problem for surgeons .',
  'Infection after total joint arthroplasty is a devastating problem that expends patient , surgeon , and hospital resources , and it substantially decreases the chances of a successful patient outcome .',
  'Periprosthetic infection in TKA is a devastating and challenging problem for both patients and surgeons .',
  'Osteomyelitis , which often arises from a surgical-site infection , is a serious problem in orthopaedic surgery .',
  'Persistent osteomyelitis is a severe and challenging problem in bone surgery .',
  'Bacterial infection associated with prosthesis implantation , or even along the lifetime of the implanted prosthesis , entails a serious problem , emphasized with immunocompromised patients .',
  'Post-operative infection is still a serious problem in orthopaedic surgery .',
  'Low-grade bone infection represents a serious clinical problem .',
  'Infections after total hip replacement are still a severe problem .',
  'Despite advances in care , infection in total joint arthroplasty remains a serious problem that has yet to be solved .',
  'Osteomyelitis remains a serious problem in the orthopedic field .',
  'Ankle infection is a serious problem with limited published information on microbiology and associated morbidities .',
  'Bone infections of patients with joint replacement by endoprosthesis ( so called " periprosthetic joint infection " ) pose a severe problem in the field of orthopedic surgery .',
  'Infections of the musculoskeletal system present a serious problem with regard to the field of orthopedic and trauma medicine .',
  'The increasing load placed by joint replacement surgery on health care systems makes infection , even with the lowest rates , a serious concern that needs to be thoroughly studied and addressed using all possible measures .',
  'A spinal infection is a serious problem for a spine surgeon , and there is currently much debate regarding how best to treat pyogenic spondylodiscitis using antibiotics and the instrumentations that have been developed to date .',
  'Infection after orthopedic procedures is a devastating and serious complication associated with significant clinical and financial challenges to the health care system and unfortunate patient .'],
 'prosthetic': ['\u2002Chronic osteomyelitis is a major challenge in orthopaedic surgery; it is the result of open fracture, periprosthetic infection and septic arthritis',
  'Infections of proximal femora with prosthetic implants in situ have long been a major concern in orthopedic surgery',
  'Infection of an expanded polytetrafluoroethylene ( ePTFE ) prosthesis after implant is a major drawback of its use in current clinical practice .',
  'Prosthetic infection is a serious concern for all arthroplasty surgeons .',
  'Postoperative infections in prosthetic surgery still constitute a serious problem , and one that is difficult to treat , because of the occurrence of agglomerates of microbes that are resistant to immune defenses and antibiotics .',
  'Resistant staphylococcal organisms remain a serious problem in the treatment of periprosthetic joint infection ( PJI ) .',
  'Periprosthetic infections remain a devastating problem in the field of joint arthroplasty .',
  'Infection remains a serious medical problem in orthopaedic surgery .',
  'Although the incidence of deep sepsis following total joint arthroplasty is lower than initially feared , it remains a serious problem for both the patient and the surgeon .',
  'Osteomyelitis in patients undergoing surgery because of injuries and diseases of the musculoskeletal system is a serious clinical , economic and social problem .',
  'Post-arthroplasty infections are a devastating problem in orthopaedic surgery .',
  'Infection after artificial joint replacement is a serious problem , which requires the re-implantation of prosthesis .',
  'Bone related-bacterial diseases including wound infections and osteomyelitis ( OM ) remain a serious problem accompanied with amputation in most severe cases .',
  'Prosthetic joint infection ( PJI ) is a severe complication for patients and represents an increasing health problem .',
  'Prosthetic joints infection is a serious medical , social and financial problem .',
  'The incidence of early deep infection after arthroplasty of the knee is very low but could represent a serious future problem .',
  'Antimicrobial resistance is a serious problem in orthopedics .',
  'Periprosthetic joint infection ( PJI ) continues to be a devastating problem in the field of total joint arthroplasty , and recent literature can be used to make the preoperative diagnosis of PJI , guide nonsurgical and surgical treatment , and provide postoperative antimicrobial management of PJI patients .',
  'Acute prosthetic infection is a serious problem .',
  'Infections with multiresistant bacteria have become a serious problem in joint arthroplasty .',
  'Periprosthetic joint infection ( PJI ) as an insurmountable challenge has always represented a serious concern for orthopedic surgeons .',
  'Infection remains a serious devastating problem for shoulder arthroplasty with an important functional impact .',
  'Methicillin-resistant Staphylococcus remains a serious problem in the treatment of periprosthetic joint infection ( PJI ) .',
  'Infections of the musculoskeletal system present a serious problem in orthopaedic and trauma medicine because , typically , they are often recurrent and associated with the development of resistance to antibiotics .',
  'Prosthetic joint infection ( PJI ) is a devastating complication in total knee arthroplasty ( TKA ) and third most common cause of revision of TKA with significant morbidity and surgical challenges .',
  'Infected nonunions resulting in segmental bone loss are a devastating complication for patients and a difficult problem for surgeons .',
  'Infection after total joint arthroplasty is a devastating problem that expends patient , surgeon , and hospital resources , and it substantially decreases the chances of a successful patient outcome .',
  'Periprosthetic infection in TKA is a devastating and challenging problem for both patients and surgeons .',
  'Osteomyelitis , which often arises from a surgical-site infection , is a serious problem in orthopaedic surgery .',
  'Persistent osteomyelitis is a severe and challenging problem in bone surgery .',
  'Bacterial infection associated with prosthesis implantation , or even along the lifetime of the implanted prosthesis , entails a serious problem , emphasized with immunocompromised patients .',
  'Post-operative infection is still a serious problem in orthopaedic surgery .',
  'Low-grade bone infection represents a serious clinical problem .',
  'Infections after total hip replacement are still a severe problem .',
  'Despite advances in care , infection in total joint arthroplasty remains a serious problem that has yet to be solved .',
  'Osteomyelitis remains a serious problem in the orthopedic field .',
  'Ankle infection is a serious problem with limited published information on microbiology and associated morbidities .',
  'Bone infections of patients with joint replacement by endoprosthesis ( so called " periprosthetic joint infection " ) pose a severe problem in the field of orthopedic surgery .',
  'Infections of the musculoskeletal system present a serious problem with regard to the field of orthopedic and trauma medicine .',
  'The increasing load placed by joint replacement surgery on health care systems makes infection , even with the lowest rates , a serious concern that needs to be thoroughly studied and addressed using all possible measures .',
  'A spinal infection is a serious problem for a spine surgeon , and there is currently much debate regarding how best to treat pyogenic spondylodiscitis using antibiotics and the instrumentations that have been developed to date .',
  'Infection after orthopedic procedures is a devastating and serious complication associated with significant clinical and financial challenges to the health care system and unfortunate patient .'],
 'osteomyelitis': ['\u2002Chronic osteomyelitis is a major challenge in orthopaedic surgery; it is the result of open fracture, periprosthetic infection and septic arthritis',
  'Infections of proximal femora with prosthetic implants in situ have long been a major concern in orthopedic surgery',
  'Infection of an expanded polytetrafluoroethylene ( ePTFE ) prosthesis after implant is a major drawback of its use in current clinical practice .',
  'Prosthetic infection is a serious concern for all arthroplasty surgeons .',
  'Postoperative infections in prosthetic surgery still constitute a serious problem , and one that is difficult to treat , because of the occurrence of agglomerates of microbes that are resistant to immune defenses and antibiotics .',
  'Resistant staphylococcal organisms remain a serious problem in the treatment of periprosthetic joint infection ( PJI ) .',
  'Periprosthetic infections remain a devastating problem in the field of joint arthroplasty .',
  'Infection remains a serious medical problem in orthopaedic surgery .',
  'Although the incidence of deep sepsis following total joint arthroplasty is lower than initially feared , it remains a serious problem for both the patient and the surgeon .',
  'Osteomyelitis in patients undergoing surgery because of injuries and diseases of the musculoskeletal system is a serious clinical , economic and social problem .',
  'Post-arthroplasty infections are a devastating problem in orthopaedic surgery .',
  'Infection after artificial joint replacement is a serious problem , which requires the re-implantation of prosthesis .',
  'Bone related-bacterial diseases including wound infections and osteomyelitis ( OM ) remain a serious problem accompanied with amputation in most severe cases .',
  'Prosthetic joint infection ( PJI ) is a severe complication for patients and represents an increasing health problem .',
  'Prosthetic joints infection is a serious medical , social and financial problem .',
  'The incidence of early deep infection after arthroplasty of the knee is very low but could represent a serious future problem .',
  'Antimicrobial resistance is a serious problem in orthopedics .',
  'Periprosthetic joint infection ( PJI ) continues to be a devastating problem in the field of total joint arthroplasty , and recent literature can be used to make the preoperative diagnosis of PJI , guide nonsurgical and surgical treatment , and provide postoperative antimicrobial management of PJI patients .',
  'Acute prosthetic infection is a serious problem .',
  'Infections with multiresistant bacteria have become a serious problem in joint arthroplasty .',
  'Periprosthetic joint infection ( PJI ) as an insurmountable challenge has always represented a serious concern for orthopedic surgeons .',
  'Infection remains a serious devastating problem for shoulder arthroplasty with an important functional impact .',
  'Methicillin-resistant Staphylococcus remains a serious problem in the treatment of periprosthetic joint infection ( PJI ) .',
  'Infections of the musculoskeletal system present a serious problem in orthopaedic and trauma medicine because , typically , they are often recurrent and associated with the development of resistance to antibiotics .',
  'Prosthetic joint infection ( PJI ) is a devastating complication in total knee arthroplasty ( TKA ) and third most common cause of revision of TKA with significant morbidity and surgical challenges .',
  'Infected nonunions resulting in segmental bone loss are a devastating complication for patients and a difficult problem for surgeons .',
  'Infection after total joint arthroplasty is a devastating problem that expends patient , surgeon , and hospital resources , and it substantially decreases the chances of a successful patient outcome .',
  'Periprosthetic infection in TKA is a devastating and challenging problem for both patients and surgeons .',
  'Osteomyelitis , which often arises from a surgical-site infection , is a serious problem in orthopaedic surgery .',
  'Persistent osteomyelitis is a severe and challenging problem in bone surgery .',
  'Bacterial infection associated with prosthesis implantation , or even along the lifetime of the implanted prosthesis , entails a serious problem , emphasized with immunocompromised patients .',
  'Post-operative infection is still a serious problem in orthopaedic surgery .',
  'Low-grade bone infection represents a serious clinical problem .',
  'Infections after total hip replacement are still a severe problem .',
  'Despite advances in care , infection in total joint arthroplasty remains a serious problem that has yet to be solved .',
  'Osteomyelitis remains a serious problem in the orthopedic field .',
  'Ankle infection is a serious problem with limited published information on microbiology and associated morbidities .',
  'Bone infections of patients with joint replacement by endoprosthesis ( so called " periprosthetic joint infection " ) pose a severe problem in the field of orthopedic surgery .',
  'Infections of the musculoskeletal system present a serious problem with regard to the field of orthopedic and trauma medicine .',
  'The increasing load placed by joint replacement surgery on health care systems makes infection , even with the lowest rates , a serious concern that needs to be thoroughly studied and addressed using all possible measures .',
  'A spinal infection is a serious problem for a spine surgeon , and there is currently much debate regarding how best to treat pyogenic spondylodiscitis using antibiotics and the instrumentations that have been developed to date .',
  'Infection after orthopedic procedures is a devastating and serious complication associated with significant clinical and financial challenges to the health care system and unfortunate patient .'],
 'adolescents': ['High prevalence rates of psychiatric morbidity have been documented among adolescents within youth correctional institutions in Nigeria',
  'One barrier to effectively treating weight issues among adolescents is that they tend to use social comparison instead of objective measures to evaluate their own health status',
  'Adolescent obesity is a serious public health concern .',
  'Substance use ( SU ) problems are common among adolescents , a serious health risk for them and a major public health problem , but are inadequately addressed in most pediatric health care settings .',
  'Substance use among college students in Iran is a serious problem . Determining the pattern of substance use among University students is an important issue for implementing prevention and treatment programs .',
  'Drug or substance abuse by adolescents continues to have a major impact on the health and well-being of young people and poses a serious management problem for health workers .',
  'Drug addiction , particularly among teenagers and young adults , has become a serious public health problem globally .',
  'The author ascertains that there are several obstacles in the recognition , treatment and prevention of child-depression that causes a serious public health problem .',
  'Obesity is a serious health problem for all age groups , particularly adolescents ; therefore , it is important for adolescents to develop healthy nutrition habits and acquire exercise behaviours .',
  'Substance use in European adolescents remains a serious health concern .',
  'NMUPD is a serious concern among adolescents and emerging adults .',
  'Nonadherence in adolescents with chronic illness is a serious problem in need of greater recognition and intervention and further research .',
  'Adolescent substance use ( SU ) remains a serious problem .',
  'Treatment-resistant depression ( TRD ) is a serious problem in adolescents .',
  'Substance abuse by adolescents is a serious problem that will touch every orthodontic practice .',
  'Low participation rates constitute a serious problem faced by family drug abuse prevention programs .',
  'Anxiety in adolescence has been a serious problem nowadays . It is seen that anxiety among students cause many harms to their mental and physical health affecting their career .',
  'Depression in inner city adolescents represents a serious problem that may be best first detected in a medical setting .',
  'While drug abuse among adolescents and young adults has begun to decline from the epidemic levels of the late 1970s , it remains a serious national health problem .',
  'The average value of BMI has increased over time ; overweight and obesity among adolescents has become a serious public health problem .',
  'Adolescent substance abuse is a serious problem in Hong Kong .',
  'Emotional and behavioural are a serious mental health concern among adolescents .',
  'Substance abuse is a serious problem in the young adult population , yet there exists a lack of reliable screening measures for use in identifying problem users in this age group .',
  'The increasing prevalence of obesity in children and adolescents is a serious public health concern .',
  'Concurrent mental health and substance use issues are a serious problem for adolescents and transition-aged youth .',
  'Adolescent substance abuse is a serious public health concern , and in response to this problem , a number of effective treatment approaches have been developed .',
  'Adolescent substance use has become a serious concern nationwide .',
  'Substance use among adolescents is a serious problem worldwide .',
  'Even among a population of middle-class adolescents having follow-up in a suburban pediatric practice , use of marijuana and other drugs may constitute a serious health and psychologic problem .',
  'Organic solvent abuse in adolescents has become a serious social problem .',
  'Depression is a serious mental health concern among adolescents .',
  'Depression is a serious mental health problem , whose first onset is usually in adolescence .',
  'Consumption of junk food among adolescents has been recognized as a serious health problem in the world .',
  'The prevalence of adolescent obesity has increased dramatically , becoming a serious public health concern .',
  'Adolescent substance use disorder ( SUD ) is a serious public health concern .',
  'Substance use disorders are a serious public health concern that affect approximately one in 12 individuals 12 years and older .',
  'Adolescent substance abuse is a serious and growing problem worldwide .',
  'Adolescent drug and alcohol addiction is a serious problem in the United States .',
  'The prevalence of adolescent obesity has increased considerably over the past decade in Switzerland and has become a serious public health problem in Europe .',
  'The use of tobacco , alcohol and psychoactive substances in a society , also by very young consumers , currently poses a serious social problem .',
  'The use of alcohol and drugs amongst young people is a serious concern and the need for effective prevention is clear .',
  'Adolescent substance abuse is a serious social problem facing the United States .',
  'Substance use by adolescents and young adults continues to be a serious problem .',
  'Depression in children and adolescents has become a serious public health problem worldwide .',
  'To examine predictors of parental perception of hyperactivity as a serious problem and its role in determining the use of specialist mental health services .',
  'Substance abuse among young people has become a serious public health problem for years .',
  'Adolescent obesity is a serious health problem associated with many comorbidities .',
  'Extreme obesity among U.S. adolescents is a serious problem and has disproportionally affected ethnic minorities .',
  'Substance use among Mexican origin , low-income youths is a serious , but under-studied problem .',
  'Background Untreated mental illness among adolescents is a serious public health concern .',
  'The Code Blue report , recently issued by a distinguished panel formed by national medical and educational associations , paints a dire picture of the state of adolescent health and recommends far-reaching measures to reverse " dangerous trends . " However , analysis of the report \'s findings reveals serious flaws in its presentation of nearly every youth problem cited , and its recommendations are much less original and workable than portrayed .',
  'Depression in adolescents is a serious problem to society because of the high prevalence rate , the high subjective burden of illness and negative ( economic ) consequences .',
  'Unhealthy eating behavior is a serious health concern among secondary school students in Inner Mongolia .',
  'The prevalence of obesity , a serious public health problem , is increasing among teenagers and thus also increases cardiovascular morbidity and mortality in adulthood .',
  'Depression during adolescence is a serious mental health problem .',
  'The concurrent or sequential usage of multiple substances during adolescence is a serious public health problem .',
  'Adolescent depression is a severe mental health problem .',
  'The use of psychotropic substances in adolescents represents a serious public health problem .',
  'Psychoactive substances use among adolescents is a serious public health problem , as it exposes them to risks and health hazards and can ultimately lead to dependence .',
  'Student substance abuse is a serious concern for middle school personnel .',
  'Alcohol and other drug use among adolescents is a serious concern , and effective prevention is critical .',
  'In conclusion , mental health disorders in children and adolescents are a serious problem associated with several potentially modifiable factors .',
  'Rising youth obesity is a serious public health concern .',
  'Findings confirmed psychopathologic conditions as a serious health concern in obese and morbidly obese adolescents .',
  'Low rates of participation constitute a serious problem for family-based drug-use prevention programs .',
  'Adolescent obesity continues to be a serious concern around the world , placing young people at risk for chronic conditions and early death .',
  'The eating habits of adolescents are a serious current public health problem .',
  'Compared with other illicit substances , stimulants are not commonly used by adolescents ; however , they represent a serious concern regarding substance use among youths .',
  'Substance use ( smoking , drinking and illicit drug use ) remains , a serious problem for young people living in industrialised countries .',
  'The high prevalence of child and adolescent psychiatric disorders in general and of aggressive behaviors in particular presents a serious problem .',
  'Parental substance abuse is a serious problem affecting the well-being of children and families .',
  '( 1 ) Depression is a serious mental health problem particularly in children and adolescents that requires early identification and intervention .',
  'Unmet need for behavioral health care is a serious problem for crossover youth , or those simultaneously involved with the child welfare and juvenile justice systems .',
  'Drug use among adolescents is a serious problem in our society , as some individuals develop dependence and addiction .',
  'Unhealthy weight control behaviors are a serious concern , impairing the quality of life in adolescents .',
  'Adolescent substance abuse is a serious problem for which effective interventions are needed .',
  'Childhood and adolescent mental health problems are a serious and growing concern worldwide .',
  'Prevalence of obesity among adolescents constitutes a serious public health problem .',
  'Substance use disorders among youth remain a serious public health problem .',
  'Substance use disorder is a serious health problem that tends to manifest in late adolescence .',
  'We have become concerned about a group of people who have the potential to live largely independently ( or semi-independently ) , to work at meaningful jobs in the community , and to make full use of the same recreational and leisure opportunities as other members of society but who are prevented from doing so because of a life-threatening behavior problem .',
  'Youth depression is a debilitating condition that constitutes a major public health concern .',
  'Several studies have been demonstrated that the adolescent substance abuse is a serious and growing problem .',
  'The average value of BMI and SFT has increased over time ; overweight and obesity among adolescents has become a serious public health problem .',
  'Dissociative behavior is widespread among these youth and may pose a serious mental health concern .',
  'Obesity was found to be a serious health problem in the population of adolescents studied , especially given the high cardiovascular risk that is characteristic of this condition .',
  'Behavioral instability in children and adolescents is a vexing problem faced by many clinicians .',
  'Substance abuse in youth is a serious public health problem , with significant morbidity and mortality .',
  'An increase in the obese adolescent population is being recognized as a serious medical and social problem .',
  'Adolescent substance use is a serious problem often invoking negative reactions .',
  'Depression is a serious mental health problem and is common in children and adolescents .'],
 'trauma': ['Childhood injuries are a global epidemic',
  'FB injuries represent a severe public health problem in childhood .',
  'Nonfatal injuries among children aged 5 - 14 years are a serious public health concern in China .',
  'Accidental strangulation is a preventable problem with limited scientific understanding in children .',
  'Foreign body ( FB ) injuries represent a severe public health problem during childhood .',
  'Muscle tissue injuries would not only result in the physical and psychological pain and disability to the patient , but also become a severe social problem due to the heavy financial burden they laid on the governments .',
  'Undertriage Remains a Vexing Problem for Even the Most Highly Developed Trauma Systems : The Need for Innovations in Field Triage .',
  'At the same time , trauma has become a serious social problem in peace time .',
  'Mutilating hand injuries in children are a devastating problem .',
  'Trauma : the burden of a preventable problem .',
  'The patient in the case reported here required a quick solution to a severe problem of self-inflicted trauma .',
  'Traumatic injury , both unintentional and intentional , is a serious public health problem .',
  'Trauma in the elderly is a serious public health problem , with a tendency to progressive worsening with population aging .',
  'Unintentional injuries continue to be a serious public-health problem for children and are higher for boys than for girls , from infancy through adulthood .',
  'Childhood injuries are a preventable problem that continue to occur with alarming frequency .',
  'Injury is a serious problem for children in SW Ontario .',
  'Major trauma , specially abdominal and thoracic trauma due to child abuse is a serious , but fortunately infrequent problem which carries unacceptably high mortality .',
  'Polytrauma treatment ( 40 - 60,000,-[symbol : see text ] ) and trauma killed victims ( 750,000,-[symbol : see text ] ) are a severe economical problem .',
  'Treadmill injuries in young children are a serious but little documented problem .',
  'The initial management of trauma patients by puskesmas nurses has several obstacles that cause delays in the treatment process ; consequently , the safety of patients becomes a serious problem .',
  'Injuries caused by accidents or violent situations in pediatric patients are a serious social problem where prevention plays a key role .',
  "On the one hand , this problem can be explained by the population 's lack of awareness for distinguished experts for hand and microsurgery , on the other hand , the emergency network , or emergency doctors in particular are not well informed about where to take a patient with a severe hand trauma - clearly a problem of communication between the hospitals and the ambulance .",
  'School injuries are a serious public health problem , yet classroom injuries have received little attention .',
  'As encountered in other studies relating to trauma , adequate follow-up has been a serious shortcoming .',
  'Home accidents are a serious public health problem in Pediatrics .',
  'Mortality and morbidity from trauma continues to be a serious , ubiquitous public health problem .',
  'Severe , multitissue hand injuries constitute a serious problem of the modern world .',
  'Table 6 which lists the cause and time of death of 52 persons with multiple injuries provides evidence that during the first 7 days after a severe accident all surgical intervention that is not absolutely necessary should be avoided and attention focused on the problem of adequate ventilation and primary and secondary complications of shock .',
  'This increasing recognition of ACEs as a preventable public health problem ( Bellis et al. , 2019 ) with roots in the community environment has spurred collective responses ( e.g. , Srivastav et al. , 2020 ) , including the emergence of multisector , community-based networks organized to address ACEs and trauma and foster resilience , or " ATR networks " ( Jones et al. , 2017 ) .',
  "A severe limb injury challenges an anesthesiologist 's ability to provide care .",
  'Cardiac-related injuries caused by blunt chest trauma remain a severe problem .',
  'Childhood and adolescent injuries have become a serious public health problem that requires the urgent attention of the government , society , schools , and families .',
  'Injury is a serious public health problem with significant social and economic costs .',
  'Trauma is a serious and escalating problem for the elderly , and increasing age is a significant risk factor for patient mortality .',
  'Trauma is a serious global health problem , accounting for approximately one in 10 deaths worldwide .',
  'Traumatic and end-stage organ loss or tissue damage remains a devastating issue for everyone , and a major problem for millions of patients .',
  'Blunt cardiac and pericardial injuries represent a serious therapeutic problem , which , if not treated properly , result in a high mortality rate .',
  'Accidental strangulation is a preventable problem , and there is limited scientific understanding of its mechanism in children .',
  'Blunt thoracic aortic injury , a life-threatening concern , remains the second most common cause of mortality among all non-penetrating traumatic injuries , second only to intracranial hemorrhage .',
  'Health disparities based on race and socioeconomic status are a serious problem in the US health care system , but disparities in outcomes related to traumatic injury have received relatively little attention in the research literature .',
  'Rib fractures are a serious problem in thoracic trauma resulting in high morbidity and mortality .',
  'Case finding and treatment of military sexual trauma ( MST ) remains a serious problem in military and veteran populations as well as in the civilian population .',
  'Injuries are a serious medical and social problem , especially when accompanied by distant or deferred effects , often causing serious dysfunctions and permanent disability for life .',
  'Childhood fatalities from injuries are a serious public health problem in New Mexico , a state which ranks second in the nation in injury-related mortality rates .',
  'Traumatic SCI is a devastating problem of health that results in high morbidity and mortality rates .',
  'Injuries in the school environment are a serious public health problem .',
  'However , to those who have lost their arms and hands due to accident or war , touching becomes a serious concern that often leads to psychosocial issues and social stigma .',
  'Between these two groups of patients lie those with blunt trauma in whom scoop and run may be most appropriate if there is major vascular damage or those in whom field stabilization may offer the patient a greater chance of survival if blood loss is not a life-threatening problem .',
  'Bicycle-related trauma is a serious pediatric problem .',
  'penetrating abdominal trauma ( PAT ) is still a serious problem all over the world .',
  'Trauma is recognized as a serious health care problem world-wide and there is a general agreement that trauma is best addressed in a systematic manner .',
  'While injuries represent a serious problem for society as a whole , the rates are significantly higher among African-Americans , especially black males between 20 and 29 years of age .',
  'All participants subsequently completed a high-stress trauma simulation , requiring diagnosis and management of a life-threatening problem .'],
 'injuries': ['Childhood injuries are a global epidemic',
  'FB injuries represent a severe public health problem in childhood .',
  'Nonfatal injuries among children aged 5 - 14 years are a serious public health concern in China .',
  'Accidental strangulation is a preventable problem with limited scientific understanding in children .',
  'Foreign body ( FB ) injuries represent a severe public health problem during childhood .',
  'Muscle tissue injuries would not only result in the physical and psychological pain and disability to the patient , but also become a severe social problem due to the heavy financial burden they laid on the governments .',
  'Undertriage Remains a Vexing Problem for Even the Most Highly Developed Trauma Systems : The Need for Innovations in Field Triage .',
  'At the same time , trauma has become a serious social problem in peace time .',
  'Mutilating hand injuries in children are a devastating problem .',
  'Trauma : the burden of a preventable problem .',
  'The patient in the case reported here required a quick solution to a severe problem of self-inflicted trauma .',
  'Traumatic injury , both unintentional and intentional , is a serious public health problem .',
  'Trauma in the elderly is a serious public health problem , with a tendency to progressive worsening with population aging .',
  'Unintentional injuries continue to be a serious public-health problem for children and are higher for boys than for girls , from infancy through adulthood .',
  'Childhood injuries are a preventable problem that continue to occur with alarming frequency .',
  'Injury is a serious problem for children in SW Ontario .',
  'Major trauma , specially abdominal and thoracic trauma due to child abuse is a serious , but fortunately infrequent problem which carries unacceptably high mortality .',
  'Polytrauma treatment ( 40 - 60,000,-[symbol : see text ] ) and trauma killed victims ( 750,000,-[symbol : see text ] ) are a severe economical problem .',
  'Treadmill injuries in young children are a serious but little documented problem .',
  'The initial management of trauma patients by puskesmas nurses has several obstacles that cause delays in the treatment process ; consequently , the safety of patients becomes a serious problem .',
  'Injuries caused by accidents or violent situations in pediatric patients are a serious social problem where prevention plays a key role .',
  "On the one hand , this problem can be explained by the population 's lack of awareness for distinguished experts for hand and microsurgery , on the other hand , the emergency network , or emergency doctors in particular are not well informed about where to take a patient with a severe hand trauma - clearly a problem of communication between the hospitals and the ambulance .",
  'School injuries are a serious public health problem , yet classroom injuries have received little attention .',
  'As encountered in other studies relating to trauma , adequate follow-up has been a serious shortcoming .',
  'Home accidents are a serious public health problem in Pediatrics .',
  'Mortality and morbidity from trauma continues to be a serious , ubiquitous public health problem .',
  'Severe , multitissue hand injuries constitute a serious problem of the modern world .',
  'Table 6 which lists the cause and time of death of 52 persons with multiple injuries provides evidence that during the first 7 days after a severe accident all surgical intervention that is not absolutely necessary should be avoided and attention focused on the problem of adequate ventilation and primary and secondary complications of shock .',
  'This increasing recognition of ACEs as a preventable public health problem ( Bellis et al. , 2019 ) with roots in the community environment has spurred collective responses ( e.g. , Srivastav et al. , 2020 ) , including the emergence of multisector , community-based networks organized to address ACEs and trauma and foster resilience , or " ATR networks " ( Jones et al. , 2017 ) .',
  "A severe limb injury challenges an anesthesiologist 's ability to provide care .",
  'Cardiac-related injuries caused by blunt chest trauma remain a severe problem .',
  'Childhood and adolescent injuries have become a serious public health problem that requires the urgent attention of the government , society , schools , and families .',
  'Injury is a serious public health problem with significant social and economic costs .',
  'Trauma is a serious and escalating problem for the elderly , and increasing age is a significant risk factor for patient mortality .',
  'Trauma is a serious global health problem , accounting for approximately one in 10 deaths worldwide .',
  'Traumatic and end-stage organ loss or tissue damage remains a devastating issue for everyone , and a major problem for millions of patients .',
  'Blunt cardiac and pericardial injuries represent a serious therapeutic problem , which , if not treated properly , result in a high mortality rate .',
  'Accidental strangulation is a preventable problem , and there is limited scientific understanding of its mechanism in children .',
  'Blunt thoracic aortic injury , a life-threatening concern , remains the second most common cause of mortality among all non-penetrating traumatic injuries , second only to intracranial hemorrhage .',
  'Health disparities based on race and socioeconomic status are a serious problem in the US health care system , but disparities in outcomes related to traumatic injury have received relatively little attention in the research literature .',
  'Rib fractures are a serious problem in thoracic trauma resulting in high morbidity and mortality .',
  'Case finding and treatment of military sexual trauma ( MST ) remains a serious problem in military and veteran populations as well as in the civilian population .',
  'Injuries are a serious medical and social problem , especially when accompanied by distant or deferred effects , often causing serious dysfunctions and permanent disability for life .',
  'Childhood fatalities from injuries are a serious public health problem in New Mexico , a state which ranks second in the nation in injury-related mortality rates .',
  'Traumatic SCI is a devastating problem of health that results in high morbidity and mortality rates .',
  'Injuries in the school environment are a serious public health problem .',
  'However , to those who have lost their arms and hands due to accident or war , touching becomes a serious concern that often leads to psychosocial issues and social stigma .',
  'Between these two groups of patients lie those with blunt trauma in whom scoop and run may be most appropriate if there is major vascular damage or those in whom field stabilization may offer the patient a greater chance of survival if blood loss is not a life-threatening problem .',
  'Bicycle-related trauma is a serious pediatric problem .',
  'penetrating abdominal trauma ( PAT ) is still a serious problem all over the world .',
  'Trauma is recognized as a serious health care problem world-wide and there is a general agreement that trauma is best addressed in a systematic manner .',
  'While injuries represent a serious problem for society as a whole , the rates are significantly higher among African-Americans , especially black males between 20 and 29 years of age .',
  'All participants subsequently completed a high-stress trauma simulation , requiring diagnosis and management of a life-threatening problem .'],
 'fracture': ['Femoral head necrosis is a progressive disease that can progress within a relatively short time',
  'Slipped capital femoral epiphysis (SCFE) is a frequent disorder of the adolescent hip, which may lead to avascular necrosis (AVN) of the femoral head, chondrolysis and early osteoarthritis due to the post-slip deformity of the proximal femur',
  'To his consternation , as he tried to demonstrate the possibility of restorative treatments , Senn found the fundamental problem with hip fractures was that the empiricism of current clinical methods created and perpetuated their own therapeutic justifications .',
  'Fracture of the femoral shaft after hip arthroplasty is a serious problem .',
  'Osteoporotic hip fracture ( HF ) is a serious global public health problem associated with high morbidity and mortality .',
  'Hip fractures in Italy are a serious medical problem and a leading health-cost driver .',
  'Hip fracture in the elderly is a serious problem , and solutions to prevent falls are needed .',
  'Non-union of fractured neck of femur in young adults is a serious problem .',
  'Despite advances in the field of orthopedic surgery , necrosis of the femoral head still remains a serious problem .',
  "The number of hip fracture surgeries exhibit an increasing trend due to the aging of the world 's population and it is expected to become a serious public health problem in the future .",
  'Fracture of the hip is a serious and frequent problem in elderly women , often resulting in a considerable loss of function and an increased mortality long after the initial episode .',
  'Hip fracture is a serious health problem and textural methods are being developed to assess bone quality .',
  'Hip fractures have become a severe public health problem , especially in very elderly patients .',
  'Although all fractures are a serious setback for the elderly person , those that do not heal properly require special considerations and the mobilization of many resources if the patient is to remain out of an institution .',
  'At the 2-year follow-up he had a serious mobilisation problem with avascular necrosis of one hip .',
  'Proximal femoral ( hip ) fractures are the leading cause of hospitalization for injuries among older persons and constitute a serious health problem .',
  'Pelvis ring fractures of geriatric patients are currently a serious problem in orthopedic and trauma surgery .',
  'Displacements of bone fragments in articular calcaneal fractures visualized radiographically by the changes of Harnroongroj et al. angle do not constitute a serious surgical problem and are easily repositioned and stabilized , as opposed to displacements resulting in changes in the value of the Böhler angle .',
  'Canine hip dysplasia ( CHD ) is a serious and common musculoskeletal disease of pedigree dogs and therefore represents both an important welfare concern and an imperative breeding priority .',
  'Severe bone deficiency in total hip arthroplasty ( THA ) represents a serious problem , and there is an increasing demand for reconstructive measurements even on the femoral side to salvage these hips .',
  'Osteonecrosis of the femoral head is a serious orthopedic problem .',
  'Hip instability leading to subluxation or dislocation is a serious problem in children suffering from CP and is usually worse in severe condition .',
  'Treatment of the above fractures is not always simple and represents a serious problem in everyday traumatological practice .',
  'High energy pelvic ring disruption represents a serious clinical problem with an overall reported mortality rate of approximately 10 % ( 1 ) .',
  'The fractures of hip joint considered as a serious problem in public health in the medical and socioeconomic issues , the incidence of the fracture neck femur is significantly increased with the increment of general population life span .',
  'Hip fracture , the most dramatic complication of osteoporosis , constitutes a serious health problem of the elderly , with great socioeconomic consequences .',
  'Femoral neck fracture is a frequently occurring and dangerous disease of elderly patient , whose morbidity is increasing gradually with the aging of population and has become a serious social problem .',
  'Distal radius fractures are a serious clinical problem .',
  'Fracture of the hip constitutes a serious social/health care problem with very little information concerning incidence in Spain being available .',
  'Hip fractures constitute a serious and common health problem from both individual and public health perspectives .',
  'Traumatic separation of the proximal femoral epiphysis in children is a serious and as yet unresolved problem .',
  'Non-healing fractures constitute a serious clinical problem .',
  'Hip fractures are a serious health problem all over the world with grave consequences for the people and health systems involved .',
  'Treatment of unstable pelvic fractures in children is a serious surgical problem .',
  'Dislocation is a serious and common complication and a great concern with the use of total hip arthroplasty ( THA ) when treating displaced femoral neck fracture ( FNF ) .',
  'Hip fracture is a serious public health problem .',
  'Fractures of the ipsilateral femur after hip arthroplasty are a serious problem .',
  'Proximal femoral fractures in elderly patients are a serious problem in the aging society .',
  'Nonunions of the femoral shaft represent a treatment challenge for the orthopaedic surgeon and a serious socioeconomic problem for the patient .',
  'PURPOSE OF THE STUDY Fragility fractures of the pelvic ring in the elderly population are a serious problem in orthopaedics .',
  'Pertrochanteric fractures currently represent a serious public health problem for which costs are definitely going to grow in the near future .',
  'Hip fracture in elderly patients is a serious health concern due to the associated morbidity and mortality .',
  'Both hip fractures and cardiovascular diseases represent in Italy a serious medical problem and a leading health cost driver , according to what has already been reported for many other Countries in the industrialized world , thus requiring a global clinical approach .',
  'The treatment of fractures of the tibial plateau or distal femur often represents a severe problem in geriatric patients .',
  'Fractures of the femoral bone shaft during and after hip arthroplasty are a serious clinical problem .',
  'The proximal femoral fracture in the elderly is a serious public health problem .',
  'The fixation of osteosynthesis screws remains a severe problem for fracture repair among osteoporotic patients .',
  'Low-energy fractures are a serious health problem in all countries with the highest incidence in Kazakhstan and Russia .',
  'Hip fractures in the elderly are a serious problem for the health service due to the high rate of complications .',
  'Persistent instability after hip revision is a serious problem .',
  'As in the femoral head , osteonecrosis is a serious problem after injury to the talus .',
  'Periprosthetic femoral fractures ( PFF ) actually represent a serious public health problem .',
  'Hip fracture constitutes a serious healthcare problem in Chile , and efforts for the prevention and management of osteoporosis are needed .',
  'Proximal humeral fractures in four or even only three parts , with metaphyseal hinge distances of < 8 \xa0 mm , represent a serious and widely debated problem .',
  'Nonunion after distal radius fracture is a serious problem and the functional prognosis is doubtful .',
  'Dislocation remains a serious concern for total hip arthroplasty ( THA ) .',
  'Hip fracture is a devastating health-care problem in a geriatric patient , leading to high mortality and morbidity .',
  'Elderly hip fracture is becoming a serious problem of public health .',
  'Patients with combined pelvic and acetabular fractures represent a serious injury that includes the resuscitative challenges of pelvic injuries coupled with the difficulties of precise reduction of acetabular fractures .',
  'Fractures of the proximal segment of the femur occurring most commonly in elderly patients are a serious , both medical ( orthopaedic ) and socioeconomic , problem .',
  'Open pelvic fractures are rare but represent a serious clinical problem with high mortality rates .',
  'Open fractures , especially III grade open fractures of the tibial diaphysis , according to the Gustilo classification still remains a serious therapeutic problem .',
  'Paralytic dislocation of the hip in adolescence is not typical , but presents a serious problem whether diagnosed primarily in adolescence or due to the lack of treatment or failed treatment in earlier age .',
  'Study of non-hip fractures , which are a serious public health problem for persons greater than or equal to 65 years of age , has been hindered by the absence of an economical method for case identification .',
  'Femoral fracture after TKR is a serious and relatively common problem , but to the best of our knowledge , only one case of femoral condylar fracture after UKA has been reported thus far .',
  'The distal articular femur fracture is a serious injury that for years has been a problem in traumatology .',
  'Hip fracture in the elderly is considered to be a serious sanitary problem .',
  'Dislocation of the hip in cerebral palsy remains a serious problem , and prevention is important .',
  'Fat embolism syndrome ( FES ) is a serious clinical problem in patients suffering from long bone fractures .',
  'Avascular necrosis of the hip is a serious clinical problem encountered by primary care physicians .',
  'Unstable intertrochanteric fractures of the hip , especially reverse oblique fractures are a serious problem in traumatology , as there is no standard method of treatment and inadequate treatment carries a significant complication rate .',
  'Ectopic bone formation following operations of the hip is a severe problem in traumatology and orthopedic surgery by reason of its high morbidity .',
  'Differentiation between traumatic and vascular aseptic bone-necrosis is a serious problem in everyday practice .',
  'Hip fractures constitute a serious healthcare problem in Ukraine , and changes in healthcare are required to improve the management and long-term care of osteoporosis and its complications .',
  'Thus , the combination of DM and fracture is becoming a serious health problem worldwide .',
  'Hip fracture is a serious health problem among older adults and often results in serious consequences such as disabilities .',
  'Femoral shaft fractures after total hip arthroplasty ( THA ) remain a serious problem , since there is no optimal surgical repair method .'],
 'femoral': ['Femoral head necrosis is a progressive disease that can progress within a relatively short time',
  'Slipped capital femoral epiphysis (SCFE) is a frequent disorder of the adolescent hip, which may lead to avascular necrosis (AVN) of the femoral head, chondrolysis and early osteoarthritis due to the post-slip deformity of the proximal femur',
  'To his consternation , as he tried to demonstrate the possibility of restorative treatments , Senn found the fundamental problem with hip fractures was that the empiricism of current clinical methods created and perpetuated their own therapeutic justifications .',
  'Fracture of the femoral shaft after hip arthroplasty is a serious problem .',
  'Osteoporotic hip fracture ( HF ) is a serious global public health problem associated with high morbidity and mortality .',
  'Hip fractures in Italy are a serious medical problem and a leading health-cost driver .',
  'Hip fracture in the elderly is a serious problem , and solutions to prevent falls are needed .',
  'Non-union of fractured neck of femur in young adults is a serious problem .',
  'Despite advances in the field of orthopedic surgery , necrosis of the femoral head still remains a serious problem .',
  "The number of hip fracture surgeries exhibit an increasing trend due to the aging of the world 's population and it is expected to become a serious public health problem in the future .",
  'Fracture of the hip is a serious and frequent problem in elderly women , often resulting in a considerable loss of function and an increased mortality long after the initial episode .',
  'Hip fracture is a serious health problem and textural methods are being developed to assess bone quality .',
  'Hip fractures have become a severe public health problem , especially in very elderly patients .',
  'Although all fractures are a serious setback for the elderly person , those that do not heal properly require special considerations and the mobilization of many resources if the patient is to remain out of an institution .',
  'At the 2-year follow-up he had a serious mobilisation problem with avascular necrosis of one hip .',
  'Proximal femoral ( hip ) fractures are the leading cause of hospitalization for injuries among older persons and constitute a serious health problem .',
  'Pelvis ring fractures of geriatric patients are currently a serious problem in orthopedic and trauma surgery .',
  'Displacements of bone fragments in articular calcaneal fractures visualized radiographically by the changes of Harnroongroj et al. angle do not constitute a serious surgical problem and are easily repositioned and stabilized , as opposed to displacements resulting in changes in the value of the Böhler angle .',
  'Canine hip dysplasia ( CHD ) is a serious and common musculoskeletal disease of pedigree dogs and therefore represents both an important welfare concern and an imperative breeding priority .',
  'Severe bone deficiency in total hip arthroplasty ( THA ) represents a serious problem , and there is an increasing demand for reconstructive measurements even on the femoral side to salvage these hips .',
  'Osteonecrosis of the femoral head is a serious orthopedic problem .',
  'Hip instability leading to subluxation or dislocation is a serious problem in children suffering from CP and is usually worse in severe condition .',
  'Treatment of the above fractures is not always simple and represents a serious problem in everyday traumatological practice .',
  'High energy pelvic ring disruption represents a serious clinical problem with an overall reported mortality rate of approximately 10 % ( 1 ) .',
  'The fractures of hip joint considered as a serious problem in public health in the medical and socioeconomic issues , the incidence of the fracture neck femur is significantly increased with the increment of general population life span .',
  'Hip fracture , the most dramatic complication of osteoporosis , constitutes a serious health problem of the elderly , with great socioeconomic consequences .',
  'Femoral neck fracture is a frequently occurring and dangerous disease of elderly patient , whose morbidity is increasing gradually with the aging of population and has become a serious social problem .',
  'Distal radius fractures are a serious clinical problem .',
  'Fracture of the hip constitutes a serious social/health care problem with very little information concerning incidence in Spain being available .',
  'Hip fractures constitute a serious and common health problem from both individual and public health perspectives .',
  'Traumatic separation of the proximal femoral epiphysis in children is a serious and as yet unresolved problem .',
  'Non-healing fractures constitute a serious clinical problem .',
  'Hip fractures are a serious health problem all over the world with grave consequences for the people and health systems involved .',
  'Treatment of unstable pelvic fractures in children is a serious surgical problem .',
  'Dislocation is a serious and common complication and a great concern with the use of total hip arthroplasty ( THA ) when treating displaced femoral neck fracture ( FNF ) .',
  'Hip fracture is a serious public health problem .',
  'Fractures of the ipsilateral femur after hip arthroplasty are a serious problem .',
  'Proximal femoral fractures in elderly patients are a serious problem in the aging society .',
  'Nonunions of the femoral shaft represent a treatment challenge for the orthopaedic surgeon and a serious socioeconomic problem for the patient .',
  'PURPOSE OF THE STUDY Fragility fractures of the pelvic ring in the elderly population are a serious problem in orthopaedics .',
  'Pertrochanteric fractures currently represent a serious public health problem for which costs are definitely going to grow in the near future .',
  'Hip fracture in elderly patients is a serious health concern due to the associated morbidity and mortality .',
  'Both hip fractures and cardiovascular diseases represent in Italy a serious medical problem and a leading health cost driver , according to what has already been reported for many other Countries in the industrialized world , thus requiring a global clinical approach .',
  'The treatment of fractures of the tibial plateau or distal femur often represents a severe problem in geriatric patients .',
  'Fractures of the femoral bone shaft during and after hip arthroplasty are a serious clinical problem .',
  'The proximal femoral fracture in the elderly is a serious public health problem .',
  'The fixation of osteosynthesis screws remains a severe problem for fracture repair among osteoporotic patients .',
  'Low-energy fractures are a serious health problem in all countries with the highest incidence in Kazakhstan and Russia .',
  'Hip fractures in the elderly are a serious problem for the health service due to the high rate of complications .',
  'Persistent instability after hip revision is a serious problem .',
  'As in the femoral head , osteonecrosis is a serious problem after injury to the talus .',
  'Periprosthetic femoral fractures ( PFF ) actually represent a serious public health problem .',
  'Hip fracture constitutes a serious healthcare problem in Chile , and efforts for the prevention and management of osteoporosis are needed .',
  'Proximal humeral fractures in four or even only three parts , with metaphyseal hinge distances of < 8 \xa0 mm , represent a serious and widely debated problem .',
  'Nonunion after distal radius fracture is a serious problem and the functional prognosis is doubtful .',
  'Dislocation remains a serious concern for total hip arthroplasty ( THA ) .',
  'Hip fracture is a devastating health-care problem in a geriatric patient , leading to high mortality and morbidity .',
  'Elderly hip fracture is becoming a serious problem of public health .',
  'Patients with combined pelvic and acetabular fractures represent a serious injury that includes the resuscitative challenges of pelvic injuries coupled with the difficulties of precise reduction of acetabular fractures .',
  'Fractures of the proximal segment of the femur occurring most commonly in elderly patients are a serious , both medical ( orthopaedic ) and socioeconomic , problem .',
  'Open pelvic fractures are rare but represent a serious clinical problem with high mortality rates .',
  'Open fractures , especially III grade open fractures of the tibial diaphysis , according to the Gustilo classification still remains a serious therapeutic problem .',
  'Paralytic dislocation of the hip in adolescence is not typical , but presents a serious problem whether diagnosed primarily in adolescence or due to the lack of treatment or failed treatment in earlier age .',
  'Study of non-hip fractures , which are a serious public health problem for persons greater than or equal to 65 years of age , has been hindered by the absence of an economical method for case identification .',
  'Femoral fracture after TKR is a serious and relatively common problem , but to the best of our knowledge , only one case of femoral condylar fracture after UKA has been reported thus far .',
  'The distal articular femur fracture is a serious injury that for years has been a problem in traumatology .',
  'Hip fracture in the elderly is considered to be a serious sanitary problem .',
  'Dislocation of the hip in cerebral palsy remains a serious problem , and prevention is important .',
  'Fat embolism syndrome ( FES ) is a serious clinical problem in patients suffering from long bone fractures .',
  'Avascular necrosis of the hip is a serious clinical problem encountered by primary care physicians .',
  'Unstable intertrochanteric fractures of the hip , especially reverse oblique fractures are a serious problem in traumatology , as there is no standard method of treatment and inadequate treatment carries a significant complication rate .',
  'Ectopic bone formation following operations of the hip is a severe problem in traumatology and orthopedic surgery by reason of its high morbidity .',
  'Differentiation between traumatic and vascular aseptic bone-necrosis is a serious problem in everyday practice .',
  'Hip fractures constitute a serious healthcare problem in Ukraine , and changes in healthcare are required to improve the management and long-term care of osteoporosis and its complications .',
  'Thus , the combination of DM and fracture is becoming a serious health problem worldwide .',
  'Hip fracture is a serious health problem among older adults and often results in serious consequences such as disabilities .',
  'Femoral shaft fractures after total hip arthroplasty ( THA ) remain a serious problem , since there is no optimal surgical repair method .'],
 'dengue': ['Since the end of the 20th century, dengue has periodically devastated Paraguay',
  'Dengue is a serious emerging infectious disease and constitutes a major international health concern .',
  'Recent reports have shown that the dengue virus ( DENV ) is a serious concern worldwide , especially in subtropical areas such as South-East Asia .',
  'Dengue virus ( DENV ) infection remains to be a serious health problem in Indonesia .',
  'Dengue remains a serious public health problem in Southeast Asia and has increased 37-fold in Malaysia compared to decades ago .',
  'Dengue is a serious global health problem endemic in Brazil .',
  'Dengue is a serious infectious disease and a growing public health problem in many tropical and sub-tropical countries .',
  'Dengue disease remains a serious public health problem in Mexico .',
  'Dengue virus ( DENV ) is a serious global health problem .',
  'Dengue fever is a serious public health problem and is emerging as a continuous threat in Guangdong Province .',
  'Dengue is a serious public health problem worldwide .',
  'Dengue fever is a severe public health problem for several countries .',
  'Dengue virus infection is a serious public health problem in endemic areas of the world where 2.5 billion people live .',
  'Dengue virus ( DENV ) , a member of the mosquito-borne flaviviruses , is a serious public health problem in many tropical countries .',
  'Dengue Haemorrhagic Fever ( DHF ) is a serious and often fatal paediatric problem in Myanmar .',
  'Dengue virus ( DV ) is the causal pathogen of dengue fever , which is one of the most rapidly spread mosquito-borne disease worldwide and has become a severe public health problem .',
  'Dengue is a serious public health problem in Metro Manila , Philippines .',
  'The lack of an appropriate model has been a serious concern in dengue research pertinent to immune response and vaccine development .',
  'Dengue virus , commonly transmitted by mosquitoes , causes a human disease of significant social impact and presents a serious public health problem in Brazil .',
  'Dengue represents a serious social and economic public health problem ; then trying to contribute to improve its control , the objective of this research was to develop phytoterapics for dengue treatment using natural resources from Caatinga biome .',
  'Dengue virus ( DV ) infections are a serious public health problem and there is currently no vaccine or drug treatment .',
  'Dengue is a serious public health problem in Colombia ; it is prevalent in 90 % of the municipalities in Quindío .',
  'Dengue is an acute , emerging , infectious disease transmitted by Aedes mosquitoes that has become a serious global public health problem .',
  'Dengue virus ( DENV ) infection has become a severe public health problem worldwide .',
  'Dengue is a serious global health concern especially in tropical and subtropical countries .',
  'Coinfection produced by dengue virus ( DENV ) and hepatitis C virus ( HCV ) is a serious problem of public health in Mexico , as they both circulate in tropical zones and may lead to masking or complicating symptoms .',
  'The escalating dengue situation in Bangladesh has been emerging as a serious public health problem in terms of morbidity and mortality .',
  'Dengue fever/dengue haemorrhagic fever/dengue shock syndrome is a serious health problem in tropical countries .',
  'Dengue fever is a serious concern for Japanese people staying in Southeast Asia .',
  'Dengue virus ( DENV ) has spread through most tropical and subtropical areas of the world and represents a serious public health problem .',
  'Dengue hemorrhagic fever ( DHF ) , a disease transmitted by Aedes mosquitos , remains a serious public health problem in Thailand .',
  'Dengue is a serious public health problem with an important economic impact .',
  'A new application of clove as larvicidal agent is an interesting strategy to combat dengue which is a serious health problem in Brazil and other tropical countries .',
  'Dengue is emerging as a serious public health problem in Tamil Nadu .',
  'The current triple epidemic caused by dengue , zika and chikungunya constitutes a serious health problem in Brazil .',
  'Dengue virus ( DENV ) infection has become a public health issue of worldwide concern and is a serious health problem in Taiwan , yet there are no approved effective antiviral drugs to treat DENV .',
  'Dengue is an acute emerging infectious disease transmitted by Aedes mosquitoes and has become a serious global public health problem .',
  'It represents a serious problem for programmes aimed at the control and prevention of dengue in tropical countries .',
  'Dengue infection poses a serious public health problem in most tropical and subtropical areas .',
  'The dengue , by the very large number of cases occurring in the area during successive epidemics -- the most important being the last one in 1977 - 1978 - -is a serious problem for public health , an epidemic of hemorrhagic dengue being a constant threat .',
  'As the primary vector for dengue , Ae . aegypti now occurs in over 20 countries and is a serious concern with reports of increasing insecticide resistance .',
  'Coinfection , coepidemics of COVID-19 , and dengue in dengue-endemic countries : A serious health concern .',
  'Dengue fever is a serious problem in Mexico and vector control has not been effective enough at preventing outbreaks .',
  'Dengue fever has rapidly manifested into a serious global health concern .',
  'Dengue infection is emerging as a serious public health problem in Tamil Nadu .',
  'Dengue is one of the main vector-borne diseases and has become a severe Public Health problem during the last decade , both in Mexico and worldwide .',
  'Dengue fever , a viral infection is re-emerging as a serious public health problem .',
  'Dengue is a serious public health problem in tropical and subtropical countries .',
  'Dengue is considered a serious public health problem in many tropical regions of the world including Brazil .',
  'Dengue has become a serious public health problem in southern China particularly with a record-breaking outbreak in 2014 .',
  'Dengue represents a serious public health problem worldwide and is caused by infection with dengue virus ( DENV ) .',
  'Dengue infection is a serious public health problem in tropical and subtropical areas .',
  'Dengue virus ( DENV ) infection , which causes dengue fever , dengue hemorrhagic fever , and dengue shock syndrome , is a severe global health problem in tropical and subtropical areas .',
  'Dengue is a serious public health problem worldwide .',
  'Dengue infection has turned into a serious health concern globally due to its high morbidity rate and a high possibility of increase in its mortality rate on the account of unavailability of any proper treatment for severe dengue infection .',
  'Dengue virus infections are a serious public health problem in tropical and subtropical areas of the world .',
  'Dengue is a serious public health problem worldwide , including in Selangor , Malaysia .',
  'Dengue is a serious problem around the globe , with 3.9 billion people at risk of the disease .',
  'Dengue fever and dengue haemorrhagic fever ( DF/DHF ) have become a serious public health problem in many parts of India in recent years .',
  'Dengue is a serious public health problem in numerous countries .',
  'Dengue is a serious public health problem worldwide , with cases reported annually in tropical and subtropical regions .',
  'Dengue fever ( DF ) is a serious public health problem in many parts of the world , and , in the absence of a vaccine , disease surveillance and mosquito vector eradication are important in controlling the spread of the disease .',
  'Dengue is a viral infection which has become a serious problem in recent years .',
  'Dengue endemic is a serious healthcare concern in tropical and subtropical countries .',
  'Dengue is a serious public health problem in Malaysia .',
  'Dengue disease is caused by any 1 of 4 dengue virus serotypes and is a serious public health concern in Latin America .',
  'Dengue virus infection is a serious health problem infecting 2.5 billion people worldwide .',
  'Dengue is the most important infectious disease in the world and is a severe public health problem .',
  'Dengue fever is a rapidly spreading mosquito-borne virus infection , which remains a serious global public health problem .',
  'Concurrently , the non-availability of an efficacious antiviral drug or vaccine and a lack of effective vector control strategies collectively make dengue a serious public health concern .',
  'Dengue virus ( DENV ) is spread through most tropical and subtropical areas of the world and represents a serious public health problem .',
  'Dengue fever has been a serious public health problem in Brazil for decades , with recurrent epidemic outbreaks occurring during summers .'],
 'borderline': ['Borderline personality disorder (BPD) is one of the most puzzling psychiatric disorders',
  'Bipolar affective disorder ( BAD ) is a severe mental illness which results in serious lifelong struggles and challenges .',
  'Borderline personality disorder ( BPD ) is a severe mental condition characterized by a range of cognitive and behavioral vulnerabilities , including chronic shame and deficits in social problem solving ( SPS ) abilities .',
  'Borderline personality disorder ( BPD ) is a serious public health problem .',
  'Borderline personality disorder is a serious mental health problem for which one of its main characteristics is significant difficulties in relationships with others .',
  'Inappropriate treatment of BPD is a serious problem in the US population .',
  'Dissociative symptoms including flashbacks , i.e. vivid scenic recollections of traumatic episodes , in patients with Borderline Personality Disorder are a serious and often treatment-refractory problem .',
  'Premature termination from group psychotherapy continues to be a serious problem in the treatment of patients with borderline personality disorder ( BPD ) .',
  'Bipolar Disorder ( BD ) is a severe mental health problem .',
  'Bipolar affective disorder is a serious and enduring mental health problem , which is associated with high mortality rates worldwide .',
  'Borderline personality disorder ( BPD ) is a severe and generally chronic disorder that presents patients and their family members with multiple challenges .'],
 'personality': ['Borderline personality disorder (BPD) is one of the most puzzling psychiatric disorders',
  'Bipolar affective disorder ( BAD ) is a severe mental illness which results in serious lifelong struggles and challenges .',
  'Borderline personality disorder ( BPD ) is a severe mental condition characterized by a range of cognitive and behavioral vulnerabilities , including chronic shame and deficits in social problem solving ( SPS ) abilities .',
  'Borderline personality disorder ( BPD ) is a serious public health problem .',
  'Borderline personality disorder is a serious mental health problem for which one of its main characteristics is significant difficulties in relationships with others .',
  'Inappropriate treatment of BPD is a serious problem in the US population .',
  'Dissociative symptoms including flashbacks , i.e. vivid scenic recollections of traumatic episodes , in patients with Borderline Personality Disorder are a serious and often treatment-refractory problem .',
  'Premature termination from group psychotherapy continues to be a serious problem in the treatment of patients with borderline personality disorder ( BPD ) .',
  'Bipolar Disorder ( BD ) is a severe mental health problem .',
  'Bipolar affective disorder is a serious and enduring mental health problem , which is associated with high mortality rates worldwide .',
  'Borderline personality disorder ( BPD ) is a severe and generally chronic disorder that presents patients and their family members with multiple challenges .'],
 'bpd': ['Borderline personality disorder (BPD) is one of the most puzzling psychiatric disorders',
  'Bipolar affective disorder ( BAD ) is a severe mental illness which results in serious lifelong struggles and challenges .',
  'Borderline personality disorder ( BPD ) is a severe mental condition characterized by a range of cognitive and behavioral vulnerabilities , including chronic shame and deficits in social problem solving ( SPS ) abilities .',
  'Borderline personality disorder ( BPD ) is a serious public health problem .',
  'Borderline personality disorder is a serious mental health problem for which one of its main characteristics is significant difficulties in relationships with others .',
  'Inappropriate treatment of BPD is a serious problem in the US population .',
  'Dissociative symptoms including flashbacks , i.e. vivid scenic recollections of traumatic episodes , in patients with Borderline Personality Disorder are a serious and often treatment-refractory problem .',
  'Premature termination from group psychotherapy continues to be a serious problem in the treatment of patients with borderline personality disorder ( BPD ) .',
  'Bipolar Disorder ( BD ) is a severe mental health problem .',
  'Bipolar affective disorder is a serious and enduring mental health problem , which is associated with high mortality rates worldwide .',
  'Borderline personality disorder ( BPD ) is a severe and generally chronic disorder that presents patients and their family members with multiple challenges .'],
 'bipolar': ['Borderline personality disorder (BPD) is one of the most puzzling psychiatric disorders',
  'Bipolar affective disorder ( BAD ) is a severe mental illness which results in serious lifelong struggles and challenges .',
  'Borderline personality disorder ( BPD ) is a severe mental condition characterized by a range of cognitive and behavioral vulnerabilities , including chronic shame and deficits in social problem solving ( SPS ) abilities .',
  'Borderline personality disorder ( BPD ) is a serious public health problem .',
  'Borderline personality disorder is a serious mental health problem for which one of its main characteristics is significant difficulties in relationships with others .',
  'Inappropriate treatment of BPD is a serious problem in the US population .',
  'Dissociative symptoms including flashbacks , i.e. vivid scenic recollections of traumatic episodes , in patients with Borderline Personality Disorder are a serious and often treatment-refractory problem .',
  'Premature termination from group psychotherapy continues to be a serious problem in the treatment of patients with borderline personality disorder ( BPD ) .',
  'Bipolar Disorder ( BD ) is a severe mental health problem .',
  'Bipolar affective disorder is a serious and enduring mental health problem , which is associated with high mortality rates worldwide .',
  'Borderline personality disorder ( BPD ) is a severe and generally chronic disorder that presents patients and their family members with multiple challenges .'],
 'affective': ['Borderline personality disorder (BPD) is one of the most puzzling psychiatric disorders',
  'Bipolar affective disorder ( BAD ) is a severe mental illness which results in serious lifelong struggles and challenges .',
  'Borderline personality disorder ( BPD ) is a severe mental condition characterized by a range of cognitive and behavioral vulnerabilities , including chronic shame and deficits in social problem solving ( SPS ) abilities .',
  'Borderline personality disorder ( BPD ) is a serious public health problem .',
  'Borderline personality disorder is a serious mental health problem for which one of its main characteristics is significant difficulties in relationships with others .',
  'Inappropriate treatment of BPD is a serious problem in the US population .',
  'Dissociative symptoms including flashbacks , i.e. vivid scenic recollections of traumatic episodes , in patients with Borderline Personality Disorder are a serious and often treatment-refractory problem .',
  'Premature termination from group psychotherapy continues to be a serious problem in the treatment of patients with borderline personality disorder ( BPD ) .',
  'Bipolar Disorder ( BD ) is a severe mental health problem .',
  'Bipolar affective disorder is a serious and enduring mental health problem , which is associated with high mortality rates worldwide .',
  'Borderline personality disorder ( BPD ) is a severe and generally chronic disorder that presents patients and their family members with multiple challenges .'],
 'drinking': ['Alcohol use/misuse is a costly public health problem, particularly among college students in the United States',
  'However , a major drawback of such programs , at least in Canada , is that the BAC restriction is lifted on completion of the GLP , which typically occurs around the age of 18 or 19 .',
  'Alcohol abuse is a serious problem for students on college campuses .',
  'Heavy drinking among young adults is a serious public health problem .',
  'Heavy drinking and associated negative consequences remain a serious problem among college students .',
  'Alcohol use disorder is a serious health problem in college students .',
  'The accidental intoxications constitute more and more a serious problem among young children in the developing countries because of their frequency and difficulties for taking care of those victims .',
  'Alcohol binge-drinking during adolescence is a serious public health concern with long-term consequences .',
  'Alcohol use is a serious public health concern among youth in South Africa and worldwide .',
  'Heavy episodic drinking ( HED ) is a serious problem among college women at high-risk for developing eating disorders ( EDs ) .',
  'Binge drinking is a serious problem among adolescents and young adults despite its adverse consequences on the brain and behavior .',
  'Episodic excessive alcohol consumption ( " binge drinking " ) among children and adolescents has become a serious public health problem in Germany and is associated with a variety of risks .',
  'Binge drinking is a serious problem among adults and youths that can be reduced by implementation of evidence-based interventions .',
  'Underage drinking poses a serious public health problem in most colleges and despite the health and safety risk , consumption of alcohol is rising .',
  'Binge alcohol drinking among adolescents has been a serious public health problem .',
  'Early-onset drinking during childhood or preadolescence is a serious social problem .',
  'Binge drinking is a serious public health problem in the United States , where it is estimated that 17.6 % adults binge drink .',
  'Binge drinking of alcohol during adolescence is a serious public health concern with long-term consequences , including decreased hippocampal and prefrontal cortex volume and deficits in memory .',
  'Underage drinking is a serious public health problem in the United States , and youth exposure to alcohol advertising has been indicated as a possible contributing factor .',
  'Heavy episodic drinking among college students is a serious health concern .',
  'Alcohol consumption is a serious problem among adolescents in Thailand and is strongly associated with various health-risk behaviors .',
  'Alcohol abuse is a serious problem among college students , and drinking games are a common , yet risky practice in this population .',
  'Underage alcohol drinking is a severe public health problem .',
  'The results indicated that from 1980 to 1985 , about one in six students attended schools that reported a serious problem with student alcohol use .',
  'Adolescent binge drinking is a serious public health concern and a risk factor for alcohol use disorder ( AUD ) and comorbid anxiety in adulthood .',
  'While binge drinking-episodic or irregular consumption of excessive amounts of alcohol-is recognised as a serious problem affecting our youth , to date there has been a lack of psychological theory and thus theoretically driven research into this problem .',
  'Alcohol misuse amongst University students is a serious concern , and research has started to investigate the feasibility of using e-health interventions .',
  'Alcohol use among university students is a serious public health concern , particularly among minority students who may use alcohol to cope with experiences of racial discrimination .',
  'Although the minimum drinking age in all 50 U. S. states is 21 years of age , drinking among underage persons ( ages 12 - 20 ) remains a serious public health concern .',
  'Because underage drinking is a serious public health concern and associated with numerous detrimental consequences , many interventions to prevent underage drinking have been developed .',
  'Content analyses of the focus group suggested that GBV is a serious problem among Kenyan college students ; GBV intersects with other problematic health behaviors like problem drinking , and despite some challenges ( e.g. , resources , time ) , VKCP is perceived to be effective at preventing GBV and supporting survivors of GBV .',
  'Heavy episodic drinking ( HED ) is a dangerous and pervasive problem in college populations .',
  'Few of the offenders were casual roisterers and the majority had a serious drinking problem .',
  'Binge drinking and other forms of ethanol abuse are , when present , a serious problem in preteens and adolescents worldwide .',
  'Binge drinking is defined as a pattern of drinking leading to intoxication in a single short session and is a serious but preventable public health problem .',
  'Alcohol consumption among adolescents is a serious public health concern .',
  'The average age of young people with alcohol intoxication has increased and parents have become stricter , but binge-drinking is still a serious problem .',
  'This paper focuses on alcohol consumption on adolescents and young people , which is a serious problem nowadays .',
  'Underage drinking is a serious societal concern , yet relatively little is known about child sipping of alcohol and its relation to beliefs about alcohol .',
  'There is considerable evidence that heavy episodic drinking ( HED ) is a serious problem among college students .',
  'Underage binge drinking is a serious health concern that is likely influenced by the neighbourhood environment .',
  'Findings showed a serious concern exists for the health and safety of the most at risk students who engaged in daily energy drink usage when two-thirds of these reported difficulties sleeping , more than one experienced heart palpitation and blood pressure ; one-third had anxiety , nervousness and feeling thirsty , and one fifth indicated tiredness and headache .',
  'Adolescent alcohol drinking , primarily in the form of binge-drinking episodes , is a serious public health concern .',
  'Binge drinking in adolescents is a serious problem that has been recognised for over a generation .',
  'Respondents from lower density areas were also more likely to report there was more alcohol/drug use and more alcohol bootlegging in the past year , and that bootlegging alcohol is a serious problem in their county .',
  'Heavy drinking and its consequences among college students represent a serious public health problem , and peer social networks are a robust predictor of drinking-related risk behaviors .',
  'Alcohol consumption among adolescents is a serious public health problem in South Korea .',
  'Binge drinking is a serious problem on many college campuses .',
  'Alcohol drinking in childhood and adolescence is a serious public health concern .',
  'Adolescent alcohol abuse remains a serious public health concern , with nearly a third of high school seniors reporting heavy drinking in the previous month .',
  'In conclusion , older adolescents who present for treatment of an assault-related injury or acute alcohol intoxication , who are alcohol-positive in the ED , and who report getting intoxicated once a month or more are likely to have a severe drinking problem .',
  'Alcoholism among minors is a serious social problem .',
  'Binge drinking of alcohol during adolescence is a serious public health concern with long-term consequences , including increased pain , fear , and anxiety .',
  'The World Health Organization ( WHO ) reported that alcohol consumption is a serious problem in adolescents .',
  'College drinking is a serious health concern .',
  'Binge alcohol drinking during adolescence is a serious health problem that may increase future risk of an alcohol use disorder .',
  'Adolescent alcohol use is a serious public health concern .',
  'Alcohol binge-drinking , especially among adolescents and young adults , is a serious public health concern .',
  'Excessive drinking among college students is a serious and pervasive public health problem .'],
 'alcohol': ['Alcohol use/misuse is a costly public health problem, particularly among college students in the United States',
  'A limitation with this perspective is that it neglects the harm drinking causes to people around the drinker , and thus , it fails to give a full picture of alcohol-related harm in society .',
  'A problem with standard drink measures is that different distilled spirits , wines , and malt beverages vary considerably in alcohol content .',
  'However , a major drawback of such programs , at least in Canada , is that the BAC restriction is lifted on completion of the GLP , which typically occurs around the age of 18 or 19 .',
  'Alcohol abuse is a serious problem for students on college campuses .',
  'Data from this study showed that exposure to medication is a serious health problem for women of reproductive age and it contributes to the increase in the number of hospitalizations .',
  'Substance abuse during pregnancy continues to be a serious health problem in the United States .',
  'Hazardous drinking ( HD ) is a serious health problem in people infected with human immunodeficiency virus type 1 ( HIV-1 ) .',
  'Heavy drinking among young adults is a serious public health problem .',
  'PRACTICAL APPLICATIONS : Alcohol abuse and alcoholism have become a serious public health problem worldwide .',
  'Alcoholism is a serious public health problem .',
  'Alcohol dependence is a serious public health problem .',
  'Use of alcohol and drugs during pregnancy is regarded as a serious problem in the medical field .',
  'Alcohol relapse after transplantation is a serious concern in transplant centers and is a subject of controversy and debate .',
  'Most studies have been carried out on individuals with a serious drinking problem , in most cases alcoholics .',
  'Alcohol and violence on farms is a serious public health problem .',
  'Heavy drinking and associated negative consequences remain a serious problem among college students .',
  'Alcohol use disorders are a serious public health concern among soldiers .',
  'Alcohol consumption is a serious problem in terms of public health because it remains a major cause of illness and premature death .',
  'Alcohol misuse , in particular binge drinking , is a serious concern among military personnel because it is strongly associated with adverse consequences and has a deleterious effect on readiness .',
  'Alcohol use disorder ( AUD ) is a devastating public health problem in which both genetic and environmental factors play a role .',
  'Alcohol use disorder is a serious health problem in college students .',
  'The accidental intoxications constitute more and more a serious problem among young children in the developing countries because of their frequency and difficulties for taking care of those victims .',
  'Alcohol binge-drinking during adolescence is a serious public health concern with long-term consequences .',
  'Ethanol addiction is a serious public health problem that still needs more effective pharmacological treatment .',
  'Alcohol use is a serious public health concern among youth in South Africa and worldwide .',
  'Heavy episodic drinking ( HED ) is a serious problem among college women at high-risk for developing eating disorders ( EDs ) .',
  'The consequences of heavy alcohol use remain a serious public health problem .',
  'Thus , it could be argued that the majority of people " recover " from alcohol problems without treatment because a substantial proportion of these individuals did not actually have a severe alcohol problem .',
  'Hazardous drinking is a serious societal concern in military populations .',
  'Binge drinking is a serious problem among adolescents and young adults despite its adverse consequences on the brain and behavior .',
  'Fetal Alcohol Syndrome ( FAS ) has been recognized as a serious developmental problem occurring in some offspring of alcoholic women .',
  'Alcohol-induced immune activation and neuroinflammation are a serious health concern for PLWH .',
  'Possibly because staff do not identify alcohol use as a serious problem for psychiatric inpatients , it is not considered in treatment planning .',
  'Alcohol abuse poses a serious public health problem , and repeated ingestion can produce tolerance , leading to dependence and addiction .',
  "Alcoholism is a serious public health concern that is characterized by the development of tolerance to alcohol 's effects , increased consumption , loss of control over drinking and the development of physical dependence .",
  'Excessive alcohol consumption poses a serious problem for public health .',
  'Clearly the level of alcohol use and abuse is high in Spain and constitutes a severe public health and socioeconomic problem .',
  'Alcoholism in Islamic countries has such a low incidence that it is not yet considered a serious public health problem of the Moslem states .',
  'Episodic excessive alcohol consumption ( " binge drinking " ) among children and adolescents has become a serious public health problem in Germany and is associated with a variety of risks .',
  'Alcohol dependence is a serious and common public health problem .',
  'Alcohol is the most commonly abused legal substance and alcoholism is a serious public health problem .',
  'Binge drinking is a serious problem among adults and youths that can be reduced by implementation of evidence-based interventions .',
  'Underage drinking poses a serious public health problem in most colleges and despite the health and safety risk , consumption of alcohol is rising .',
  'Binge alcohol drinking among adolescents has been a serious public health problem .',
  "We use data from the Fragile Families and Child Wellbeing Study , augmented with information from hospital medical records , to estimate the effects of the birth of a child with a severe health problem on the likelihood that the infant 's father engages in illegal activities .",
  'A majority of cases had a severe drinking problem ; in fact , alcoholism was twice as common as initially anticipated .',
  'Alcoholism is a serious public health problem throughout the world .',
  'Alcohol-related violence is a serious and common social problem .',
  'Alcohol use disorders ( AUDs ) represent a severe , world-wide problem , and are usually comorbid with psychiatric disorders , comorbidity increases the risks associated with AUDs , and results in more serious consequences for patients .',
  'In recent years , alcohol-related health and social problems have become a serious concern in Japan because of the marked increase in per capita alcohol consumption .',
  'Binge drinking continues to be a serious public health concern .',
  'Excessive alcohol use is a serious public health concern worldwide , but less attention has been given to the prevalence , risk and protective factors , and consequences of early alcohol use in low-income , developing countries .',
  'Early-onset drinking during childhood or preadolescence is a serious social problem .',
  'Binge drinking is a serious public health problem in the United States , where it is estimated that 17.6 % adults binge drink .',
  'Alcohol abuse and dependence are a serious public health problem .',
  'Binge drinking of alcohol during adolescence is a serious public health concern with long-term consequences , including decreased hippocampal and prefrontal cortex volume and deficits in memory .',
  'Illicit drug use during pregnancy is a serious social and public health problem inflicting an array of deleterious effects on both mother and offspring .',
  'Due to its negative impact on both health and productivity , alcohol misuse is a serious concern in the workplace .',
  'One patient in 10 showed a severe alcohol-related problem .',
  'Underage drinking is a serious public health problem in the United States , and youth exposure to alcohol advertising has been indicated as a possible contributing factor .',
  'Foetal exposure to maternally administered opiates such as morphine represent a serious human health problem but disposition studies in man are difficult to perform .',
  'Heavy episodic drinking among college students is a serious health concern .',
  'James Bond has a severe chronic alcohol problem .',
  'Alcohol consumption is a serious problem among adolescents in Thailand and is strongly associated with various health-risk behaviors .',
  'We wished to determine if offspring of families exhibiting a positive history of alcoholism ( FH+ ) reported a serious alcohol or drug problem ( including seeking treatment ) at a higher rate than those without such backgrounds ( FH- ) .',
  'The lack of information needed to assess the safety of drug treatments during human pregnancy remains a serious public health problem .',
  'Alcohol abuse is a serious problem among college students , and drinking games are a common , yet risky practice in this population .',
  'Underage alcohol drinking is a severe public health problem .',
  'Cocaine addiction is a serious health problem for pregnant women and their babies .',
  'The results indicated that from 1980 to 1985 , about one in six students attended schools that reported a serious problem with student alcohol use .',
  'Adolescent binge drinking is a serious public health concern and a risk factor for alcohol use disorder ( AUD ) and comorbid anxiety in adulthood .',
  'This study revealed that problem drinking and alcohol dependence are a serious problem in Japanese general population .',
  'While binge drinking-episodic or irregular consumption of excessive amounts of alcohol-is recognised as a serious problem affecting our youth , to date there has been a lack of psychological theory and thus theoretically driven research into this problem .',
  'The mass incarceration of pregnant and parenting women is a serious problem in U.S. A policy focus is needed that takes a public health approach .',
  'The excessive intake of alcohol is a serious public health problem , especially given the severe damage provoked by chronic or prenatal exposure to alcohol that affects many physiological processes , such as memory , motor function , and cognitive abilities .',
  'Alcohol misuse amongst University students is a serious concern , and research has started to investigate the feasibility of using e-health interventions .',
  'With the number of chronic heavy users of ethanol in the United States estimated to be 15 to 20 million and the evidence increasing that ethanol causes serious cardiac metabolic disturbances , ethanol abuse is obviously a serious problem and most likely is an important contributing factor to cardiac morbidity and mortality .',
  'Alcohol use among university students is a serious public health concern , particularly among minority students who may use alcohol to cope with experiences of racial discrimination .',
  'Pathological and social consequences associated with excessive alcohol consumption and dependence constitute a serious concern for human well-being .',
  'Although the minimum drinking age in all 50 U. S. states is 21 years of age , drinking among underage persons ( ages 12 - 20 ) remains a serious public health concern .',
  'Alcoholism is a serious health problem .',
  'Because underage drinking is a serious public health concern and associated with numerous detrimental consequences , many interventions to prevent underage drinking have been developed .',
  'Drinking alcohol in pregnancy is a serious public health concern worldwide .',
  'Content analyses of the focus group suggested that GBV is a serious problem among Kenyan college students ; GBV intersects with other problematic health behaviors like problem drinking , and despite some challenges ( e.g. , resources , time ) , VKCP is perceived to be effective at preventing GBV and supporting survivors of GBV .',
  'Heavy episodic drinking ( HED ) is a dangerous and pervasive problem in college populations .',
  'This conservative rate -- nearly one in every 100 live births -- confirms the perception of many health professionals that fetal alcohol exposure is a serious problem .',
  'Consumption of alcohol is a serious social problem .',
  'Few of the offenders were casual roisterers and the majority had a serious drinking problem .',
  'Harmful alcohol consumption in Germany is a serious public health problem : About 7.7 million adults in Germany can be classified as risky alcohol consumers , about 74,000 deaths per year are related to alcohol consumption , and about 1.8 million adults in Germany ( 18 - 64 \u2009 years ) are classified as alcohol dependent .',
  'Alcohol use disorder ( AUD ) persists as a devastating public health problem ; widely effective pharmacological treatments are needed .',
  'Alcohol is a serious public health concern that has a differential impact on individuals depending upon age and sex .',
  'Binge drinking and other forms of ethanol abuse are , when present , a serious problem in preteens and adolescents worldwide .',
  'Binge drinking is defined as a pattern of drinking leading to intoxication in a single short session and is a serious but preventable public health problem .',
  'Ethanol use disorders are a serious medical and public health problem in the world today .',
  'The Alcohol Dependence Syndrome ( ADS ) is a serious problem of public health .',
  'Despite a recent decline in per capita alcohol consumption , alcoholism remains a serious public health problem in France .',
  'Alcoholism is a serious public health problem and has been identified as the third major cause of preventable mortality in the world .',
  'False negatives in the assessment of lifetime alcohol use disorders : a serious but unappreciated problem .',
  'Alcohol dependence encompasses a serious medical and societal problem that constitutes a major public health concern .',
  'Alcohol consumption among adolescents is a serious public health concern .',
  'Alcohol abuse is a serious medical and social problem .',
  'Preliminary studies on the effects of antabus ( tetraethylthiuram disulfide ) in the therapy of alcoholic patients indicate that it is very valuable in providing a " chemical foundation " for sobriety , even in those with a severe , long term drinking problem .',
  'The average age of young people with alcohol intoxication has increased and parents have become stricter , but binge-drinking is still a serious problem .',
  'Injury is a serious problem for a substantial proportion of patients who undergo detoxification , particularly those with alcohol dependence .',
  'Problems with alcohol remain a serious public health concern despite decreased use among some populations .',
  'Alcohol dependence , a chronic relapsing brain disease with the characteristics of drinking alcohol out of control , has become a serious social problem .',
  'This paper focuses on alcohol consumption on adolescents and young people , which is a serious problem nowadays .',
  'Outbreak of Botulism Due to Illicit Prison-Brewed Alcohol : Public Health Response to a Serious and Recurrent Problem .',
  'Drug of abuse consumption throughout pregnancy is a serious public health problem and an important economic cost to the health system .',
  '[ Editorial : Alcohol -- a serious problem ] .',
  'Underage drinking is a serious societal concern , yet relatively little is known about child sipping of alcohol and its relation to beliefs about alcohol .',
  'Intoxicated aggression is both a dangerous and a costly problem for society , with alcohol being involved in over 50 % of violent crimes , and the cost of alcohol-consumption-related crime being estimated at $ 205 billion in the United States alone .',
  'There is considerable evidence that heavy episodic drinking ( HED ) is a serious problem among college students .',
  'Despite extensive public health campaigns , the consequences of alcohol intoxication continue to be a serious public health concern .',
  'The use of addictive substances during pregnancy is a serious social problem , not only because of effects on the health of the woman and child , but also because drug or alcohol dependency detracts from child care and enhances the prospect of child neglect and family breakdown .',
  'The prevalence of gastric mucosal injury caused by alcohol has been on the rise , which has been considered a serious problem .',
  'Alcoholism is a serious public health problem in Chile and the best treatment strategy for this problem is far from being clear .',
  'Underage binge drinking is a serious health concern that is likely influenced by the neighbourhood environment .',
  'Patients with acute alcohol intoxication present a serious and still growing problem for pre- and intra-hospital emergency services .',
  'Despite the fact that alcoholism is a severe public health problem of worldwide proportions , only a limited number of medications is used as coadjuvant treatment .',
  'Each year , 17 million adults experience a serious problem with alcohol , but only 3 million get help .',
  'Findings showed a serious concern exists for the health and safety of the most at risk students who engaged in daily energy drink usage when two-thirds of these reported difficulties sleeping , more than one experienced heart palpitation and blood pressure ; one-third had anxiety , nervousness and feeling thirsty , and one fifth indicated tiredness and headache .',
  'Drinking alcohol in pregnancy is of a serious public health concern worldwide .',
  'Maternal substance abuse is a serious problem with significant adverse effects to mothers , fetuses , and children .',
  'Alcohol dependence ( AD ) is a serious and common public health problem .',
  'Alcohol abuse and dependence represents a serious health problem worldwide with social , interpersonal and legal interpolations .',
  'With the exception of Denmark , alcohol has for a long time been regarded as a serious public health problem , and the reduction of total consumption of alcohol has been held as one of the most important ways of combating alcohol problems .',
  'Participants ( N = 25 ) with a severe mental illness who were receiving mental health outpatient treatment at a state psychiatric hospital were interviewed regarding the resolution of their alcohol problem .',
  'Adolescent alcohol drinking , primarily in the form of binge-drinking episodes , is a serious public health concern .',
  'Alcoholism and alcohol-related problems in Latin America constitute a serious problem that may be increasing despite variations by ethnicity , country , and other variables .',
  "Although support was not found for anger as a mediator , there was strong convergence between AA 's explicit emphasis on anger and the present findings : Anger appears to be a serious , enduring problem related to relapse and heavy alcohol consumption .",
  'Alcohol abuse and dependence , defined in the Diagnostic and Statistical Manual of Mental Disorders ( 3rd edition , revised ) , is a serious mental health problem in older adults .',
  'Alcohol dependence constitutes a serious worldwide public health problem .',
  'Binge drinking in adolescents is a serious problem that has been recognised for over a generation .',
  'Respondents from lower density areas were also more likely to report there was more alcohol/drug use and more alcohol bootlegging in the past year , and that bootlegging alcohol is a serious problem in their county .',
  'Excessive alcohol intake can pose a serious problem in public health .',
  'Heavy drinking and its consequences among college students represent a serious public health problem , and peer social networks are a robust predictor of drinking-related risk behaviors .',
  'Alcohol consumption among adolescents is a serious public health problem in South Korea .',
  'Alcohol abuse is a serious health problem , leading to life-threatening damage to most of the important organ systems .',
  'At the HIV outpatient department of the University Hospital in Basel , nurses are assessing patients and it is evident that alcohol intake is a serious health problem for some of them .',
  'Fetal alcohol exposure is a serious social and public health problem .',
  'Alcohol abuse and addiction is not only a severe social problem , but also an important biological medical issue .',
  'The person with alcoholism was viewed as having a serious problem by only slightly more than half of the respondents .',
  'Prenatal alcohol exposure ( PAE ) continues to be a serious public health problem , yet no reliable clinical tools are available for assessing levels of drinking during pregnancy .',
  'Fetal alcohol syndrome ( FAS ) is a serious global health problem and is observed at high frequencies in certain South African communities .',
  'Fetal exposure to alcohol is a serious public health problem and is associated with anomalies of the eye ground , as well as neurodevelopmental delay , growth delay , and characteristic facial features .',
  'Historically , substance misuse has been a serious problem faced by worldwide military personnel .',
  'Fetal drug addiction is a serious public health problem .',
  'Problematic drinking is a serious and persistent problem among U.S. military service members and veterans , who face barriers to seeking help and are less likely to seek help than the civilian population .',
  'Western Balkan countries exhibit high levels of alcohol consumption , which constitutes a serious public health concern .',
  'Binge drinking is a serious problem on many college campuses .',
  'A serious problem is the evaluation of retrospective drug risks in cases of drugs administered before pregnancy was confirmed .',
  'Alcohol drinking in childhood and adolescence is a serious public health concern .',
  'Adolescent alcohol abuse remains a serious public health concern , with nearly a third of high school seniors reporting heavy drinking in the previous month .',
  'Problem drinking is a serious public health problem in the workplace .',
  'In conclusion , older adolescents who present for treatment of an assault-related injury or acute alcohol intoxication , who are alcohol-positive in the ED , and who report getting intoxicated once a month or more are likely to have a severe drinking problem .',
  'Alcoholism among minors is a serious social problem .',
  'Fetal alcohol spectrum disorder ( FASD ) is a serious and widespread problem in this country .',
  'Binge drinking of alcohol during adolescence is a serious public health concern with long-term consequences , including increased pain , fear , and anxiety .',
  'Alcohol use disorder is a serious health problem with high comorbidities .',
  'Alcohol use disorders ( AUDs ) are a devastating public health problem .',
  'A variety of public education programs developed over the last 20 years have promoted alcohol abstention during pregnancy , yet FASD remains a serious public health concern .',
  'Alcohol-related diseases represent a serious problem all over the world and they show a gradually increasing tendency .',
  'Excessive alcohol intake is a serious but preventable public health problem in the United States and worldwide .',
  'Alcohol use disorder ( AUD ) is a serious public health problem that results in tremendous social , legal and medical costs to society .',
  'The growing number of pregnant women using illicit substances presents a serious public health concern .',
  'The World Health Organization ( WHO ) reported that alcohol consumption is a serious problem in adolescents .',
  'Alcoholism in the elderly . A serious but solvable problem .',
  'College drinking is a serious health concern .',
  'Binge alcohol drinking during adolescence is a serious health problem that may increase future risk of an alcohol use disorder .',
  'Ethanol withdrawal is a serious clinical problem owing in part to over stimulation of ionotropic glutamate receptors in the brain and is linked to elevated oxidative damage .',
  'Adolescent alcohol use is a serious public health concern .',
  'Alcohol misuse has now become a serious public health problem and early intervention is important in minimizing the harm .',
  'Scotland has a serious problem with alcohol .',
  'Consumption of drugs of abuse , tobacco and alcohol throughout pregnancy is a serious public health problem and results in an important economic cost to the health system .',
  'Heroin abuse during pregnancy is a serious problem worldwide .',
  'Drug abuse by pregnant women is considered a serious public health problem worldwide .',
  'Hence , alterations in its activity caused by the transfer of maternal drugs over a prolonged period of time could pose a serious problem to nurslings when they require drugs for their own benefit .',
  'Gastric mucosal damage induced by ethanol is a serious medical problem .',
  'Smoking is a serious health concern both globally and in the U.S. Because drinking amplifies the negative health effects of smoking , the high association of these behaviors is an additional source of population morbidity .',
  'Alcohol binge-drinking , especially among adolescents and young adults , is a serious public health concern .',
  'Alcoholism is a serious problem throughout the world .',
  'Excessive drinking among college students is a serious and pervasive public health problem .',
  'Alcoholism , one of the most frequent diseases in the world , has been transformed in a serious social problem and in Brazil , it has triplicated in the last decades .',
  'Alcohol problems are a serious public health concern , and few problem drinkers ever seek treatment .',
  'Alcohol dependence poses a serious medical and sociological problem .',
  'A positive BT in the presence of a positive CAGE occurred in three patients and although insensitive it was absolutely specific for a serious drinking problem .',
  'Alcohol abuse is a serious health problem worldwide that causes a variety of physical and mental disorders .',
  'The findings , such as 3 % daily drinkers , clearly indicated a worrisome prevalence of non-ritual alcohol use among Israelis and reinforced the position that the phenomenon of drinking is liable to develop into an important social and public health problem in the State of Israel .',
  'Never previously reported is whether this " quantitative " approach to screening can be used to effectively screen ambulatory patients for the presence of a serious drinking problem .'],
 'college': ['Alcohol use/misuse is a costly public health problem, particularly among college students in the United States',
  'However , a major drawback of such programs , at least in Canada , is that the BAC restriction is lifted on completion of the GLP , which typically occurs around the age of 18 or 19 .',
  'Alcohol abuse is a serious problem for students on college campuses .',
  'Heavy drinking among young adults is a serious public health problem .',
  'Heavy drinking and associated negative consequences remain a serious problem among college students .',
  'Alcohol use disorder is a serious health problem in college students .',
  'The accidental intoxications constitute more and more a serious problem among young children in the developing countries because of their frequency and difficulties for taking care of those victims .',
  'Alcohol binge-drinking during adolescence is a serious public health concern with long-term consequences .',
  'Alcohol use is a serious public health concern among youth in South Africa and worldwide .',
  'Heavy episodic drinking ( HED ) is a serious problem among college women at high-risk for developing eating disorders ( EDs ) .',
  'Binge drinking is a serious problem among adolescents and young adults despite its adverse consequences on the brain and behavior .',
  'Episodic excessive alcohol consumption ( " binge drinking " ) among children and adolescents has become a serious public health problem in Germany and is associated with a variety of risks .',
  'Binge drinking is a serious problem among adults and youths that can be reduced by implementation of evidence-based interventions .',
  'Underage drinking poses a serious public health problem in most colleges and despite the health and safety risk , consumption of alcohol is rising .',
  'Binge alcohol drinking among adolescents has been a serious public health problem .',
  'Early-onset drinking during childhood or preadolescence is a serious social problem .',
  'Binge drinking is a serious public health problem in the United States , where it is estimated that 17.6 % adults binge drink .',
  'Binge drinking of alcohol during adolescence is a serious public health concern with long-term consequences , including decreased hippocampal and prefrontal cortex volume and deficits in memory .',
  'Underage drinking is a serious public health problem in the United States , and youth exposure to alcohol advertising has been indicated as a possible contributing factor .',
  'Heavy episodic drinking among college students is a serious health concern .',
  'Alcohol consumption is a serious problem among adolescents in Thailand and is strongly associated with various health-risk behaviors .',
  'Alcohol abuse is a serious problem among college students , and drinking games are a common , yet risky practice in this population .',
  'Underage alcohol drinking is a severe public health problem .',
  'The results indicated that from 1980 to 1985 , about one in six students attended schools that reported a serious problem with student alcohol use .',
  'Adolescent binge drinking is a serious public health concern and a risk factor for alcohol use disorder ( AUD ) and comorbid anxiety in adulthood .',
  'While binge drinking-episodic or irregular consumption of excessive amounts of alcohol-is recognised as a serious problem affecting our youth , to date there has been a lack of psychological theory and thus theoretically driven research into this problem .',
  'Alcohol misuse amongst University students is a serious concern , and research has started to investigate the feasibility of using e-health interventions .',
  'Alcohol use among university students is a serious public health concern , particularly among minority students who may use alcohol to cope with experiences of racial discrimination .',
  'Although the minimum drinking age in all 50 U. S. states is 21 years of age , drinking among underage persons ( ages 12 - 20 ) remains a serious public health concern .',
  'Because underage drinking is a serious public health concern and associated with numerous detrimental consequences , many interventions to prevent underage drinking have been developed .',
  'Content analyses of the focus group suggested that GBV is a serious problem among Kenyan college students ; GBV intersects with other problematic health behaviors like problem drinking , and despite some challenges ( e.g. , resources , time ) , VKCP is perceived to be effective at preventing GBV and supporting survivors of GBV .',
  'Heavy episodic drinking ( HED ) is a dangerous and pervasive problem in college populations .',
  'Few of the offenders were casual roisterers and the majority had a serious drinking problem .',
  'Binge drinking and other forms of ethanol abuse are , when present , a serious problem in preteens and adolescents worldwide .',
  'Binge drinking is defined as a pattern of drinking leading to intoxication in a single short session and is a serious but preventable public health problem .',
  'Alcohol consumption among adolescents is a serious public health concern .',
  'The average age of young people with alcohol intoxication has increased and parents have become stricter , but binge-drinking is still a serious problem .',
  'This paper focuses on alcohol consumption on adolescents and young people , which is a serious problem nowadays .',
  'Underage drinking is a serious societal concern , yet relatively little is known about child sipping of alcohol and its relation to beliefs about alcohol .',
  'There is considerable evidence that heavy episodic drinking ( HED ) is a serious problem among college students .',
  'Underage binge drinking is a serious health concern that is likely influenced by the neighbourhood environment .',
  'Findings showed a serious concern exists for the health and safety of the most at risk students who engaged in daily energy drink usage when two-thirds of these reported difficulties sleeping , more than one experienced heart palpitation and blood pressure ; one-third had anxiety , nervousness and feeling thirsty , and one fifth indicated tiredness and headache .',
  'Adolescent alcohol drinking , primarily in the form of binge-drinking episodes , is a serious public health concern .',
  'Binge drinking in adolescents is a serious problem that has been recognised for over a generation .',
  'Respondents from lower density areas were also more likely to report there was more alcohol/drug use and more alcohol bootlegging in the past year , and that bootlegging alcohol is a serious problem in their county .',
  'Heavy drinking and its consequences among college students represent a serious public health problem , and peer social networks are a robust predictor of drinking-related risk behaviors .',
  'Alcohol consumption among adolescents is a serious public health problem in South Korea .',
  'Binge drinking is a serious problem on many college campuses .',
  'Alcohol drinking in childhood and adolescence is a serious public health concern .',
  'Adolescent alcohol abuse remains a serious public health concern , with nearly a third of high school seniors reporting heavy drinking in the previous month .',
  'In conclusion , older adolescents who present for treatment of an assault-related injury or acute alcohol intoxication , who are alcohol-positive in the ED , and who report getting intoxicated once a month or more are likely to have a severe drinking problem .',
  'Alcoholism among minors is a serious social problem .',
  'Binge drinking of alcohol during adolescence is a serious public health concern with long-term consequences , including increased pain , fear , and anxiety .',
  'The World Health Organization ( WHO ) reported that alcohol consumption is a serious problem in adolescents .',
  'College drinking is a serious health concern .',
  'Binge alcohol drinking during adolescence is a serious health problem that may increase future risk of an alcohol use disorder .',
  'Adolescent alcohol use is a serious public health concern .',
  'Alcohol binge-drinking , especially among adolescents and young adults , is a serious public health concern .',
  'Excessive drinking among college students is a serious and pervasive public health problem .'],
 'tick': ['Babesiosis, a tick-borne illness spread by Ixodes scapularis, is an emerging infectious disease in the Northeastern and upper Midwestern United States',
  'Ticks were not directly or indirectly implicated in any of 16 mortalities that occurred among 61 radio-collared fawns monitored for approximately 6 mo post-partum , and were not considered a serious health problem for fawns on the study area .',
  'Our studies indicate that Lyme borreliosis is a serious health problem among the inhabitants of Podlasie Province which is an endemic area for Ixodes ricinus ticks infected with B. burgdorferi spirochete .',
  'Despite efforts to control tick infestations , they remain a serious health problem .',
  'Ticks infesting cattle represent a serious problem for improvement of cattle productivity in   South Sudan .',
  'Lyme borreliosis has become a serious diagnostic and therapeutic problem of modern medicine .',
  'In the recent years , TBEV has become a serious public health problem with a steady increase in its incidence , mainly due to the climate changes and spreading the infected ticks into new territories .',
  'From tick bite to treatment , Lyme disease is a serious concern for those who reside in parts of the world where this infectious disorder is endemic .',
  'Lyme disease is a serious health problem , with many patients requiring in-depth clinical assessment and extended treatment .',
  'Despite efforts to control tick infestations , these ectoparasites remain a serious problem for human and animal health(4,5 ) .',
  'Tick-borne encephalitis ( TBE ) virus , which is usually divided into European , Far Eastern and Siberian subtypes , is a serious public health problem in several European and Asian countries .',
  'The cattle tick Boophilus microplus is a serious concern to the Brazilian cattle industry .',
  'New Babesia species have been identified globally , suggesting that the epidemiology of this disease is rapidly changing , making it clear that human babesiosis is a serious public health concern that requires close monitoring and effective intervention measures .',
  'The rapidly increasing incidence of Lyme disease has become a serious public health problem .',
  'Cattle tick control remains a serious problem for cattle farms in Brazil due to the limited success achieved with chemicals .',
  'The geographical expansion of the tick Ixodes ricinus in northern Europe is a serious concern for animal and human health .',
  'For each of 3 herd sizes of 250 , 500 and 1,000 cattle , comparisons were made of the costs of 4 different control options : ( i ) Intensive dipping ( 40 times/year ) ( ii ) Intensive pour-on acaricide treatments ( 18 times/year ) ( iii ) Theileria immunisation with strategic dipping ( 6 times/year ) ( iv ) Theileria immunisation with pour-on treatment ( 4 times/year ) It is concluded from these studies that , on farms where theileriosis is a serious problem , immunisation coupled with a strategic dipping programme is economically very attractive .',
  'Bovine theileriosis , a tick-borne protozoan disease caused by Theileria annulata , Theileria orientalis and Theileria sinensis , is widespread in China and is a serious economic problem for the Chinese livestock industry .',
  'Tick-borne encephalitis ( TBE ) is a severe problem in Lithuania , indicated by the 171 to 645 serologically confirmed cases that occurred each year between 1993 and 1999 .',
  'Tick-borne infections have been increasing steadily over the years , with co-infections with Borrelia burgdorferi and Babesia microti/divergens emerging as a serious health problem .',
  'Cattle tick control remains a serious problem in cattle farms worldwide , due to the limited success achieved with chemicals .',
  'The high incidence of Lyme borreliosis among the residents of endemic areas , along with diagnostic and therapeutic difficulties , make it a serious academic , clinical and social problem .',
  'Lyme disease in Poland - A serious problem ?',
  'Current methods for the control of cattle tick Boophilus microplus infestations are not effective and the parasite remains a serious problem for the cattle industry in tropical and subtropical areas .',
  'Current methods for the control of the cattle tick Boophilus microplus infestations are not effective and the parasite remains a serious problem for the cattle industry in tropical and sub-tropical areas .',
  'Lyme Borreliosis is a serious diagnostical and therapeutical problem in regions with high exposure of residents to ticks , which are Borrelia burgdorferi vectors .',
  'Tick-borne illnesses pose a serious concern to human and veterinary health and their prevalence is on the rise .',
  'Tick-borne encephalitis virus ( TBEV ) is a severe problem in Estonia .',
  'The use of traditional control methods has been only partially successful and tick infestations remain a serious problem .',
  'Tick infestations and tick-borne diseases ( TBDs ) remain a serious and persistent problem , due to the lack of efficient control measures .',
  'Ticks parasitizing on reptiles are known as vectors of tick-borne diseases , which indicate a serious epidemic problem , created by the import of exotic reptiles to the territory of Poland .'],
 'lyme': ['Babesiosis, a tick-borne illness spread by Ixodes scapularis, is an emerging infectious disease in the Northeastern and upper Midwestern United States',
  'Ticks were not directly or indirectly implicated in any of 16 mortalities that occurred among 61 radio-collared fawns monitored for approximately 6 mo post-partum , and were not considered a serious health problem for fawns on the study area .',
  'Our studies indicate that Lyme borreliosis is a serious health problem among the inhabitants of Podlasie Province which is an endemic area for Ixodes ricinus ticks infected with B. burgdorferi spirochete .',
  'Despite efforts to control tick infestations , they remain a serious health problem .',
  'Ticks infesting cattle represent a serious problem for improvement of cattle productivity in   South Sudan .',
  'Lyme borreliosis has become a serious diagnostic and therapeutic problem of modern medicine .',
  'In the recent years , TBEV has become a serious public health problem with a steady increase in its incidence , mainly due to the climate changes and spreading the infected ticks into new territories .',
  'From tick bite to treatment , Lyme disease is a serious concern for those who reside in parts of the world where this infectious disorder is endemic .',
  'Lyme disease is a serious health problem , with many patients requiring in-depth clinical assessment and extended treatment .',
  'Despite efforts to control tick infestations , these ectoparasites remain a serious problem for human and animal health(4,5 ) .',
  'Tick-borne encephalitis ( TBE ) virus , which is usually divided into European , Far Eastern and Siberian subtypes , is a serious public health problem in several European and Asian countries .',
  'The cattle tick Boophilus microplus is a serious concern to the Brazilian cattle industry .',
  'New Babesia species have been identified globally , suggesting that the epidemiology of this disease is rapidly changing , making it clear that human babesiosis is a serious public health concern that requires close monitoring and effective intervention measures .',
  'The rapidly increasing incidence of Lyme disease has become a serious public health problem .',
  'Cattle tick control remains a serious problem for cattle farms in Brazil due to the limited success achieved with chemicals .',
  'The geographical expansion of the tick Ixodes ricinus in northern Europe is a serious concern for animal and human health .',
  'For each of 3 herd sizes of 250 , 500 and 1,000 cattle , comparisons were made of the costs of 4 different control options : ( i ) Intensive dipping ( 40 times/year ) ( ii ) Intensive pour-on acaricide treatments ( 18 times/year ) ( iii ) Theileria immunisation with strategic dipping ( 6 times/year ) ( iv ) Theileria immunisation with pour-on treatment ( 4 times/year ) It is concluded from these studies that , on farms where theileriosis is a serious problem , immunisation coupled with a strategic dipping programme is economically very attractive .',
  'Bovine theileriosis , a tick-borne protozoan disease caused by Theileria annulata , Theileria orientalis and Theileria sinensis , is widespread in China and is a serious economic problem for the Chinese livestock industry .',
  'Tick-borne encephalitis ( TBE ) is a severe problem in Lithuania , indicated by the 171 to 645 serologically confirmed cases that occurred each year between 1993 and 1999 .',
  'Tick-borne infections have been increasing steadily over the years , with co-infections with Borrelia burgdorferi and Babesia microti/divergens emerging as a serious health problem .',
  'Cattle tick control remains a serious problem in cattle farms worldwide , due to the limited success achieved with chemicals .',
  'The high incidence of Lyme borreliosis among the residents of endemic areas , along with diagnostic and therapeutic difficulties , make it a serious academic , clinical and social problem .',
  'Lyme disease in Poland - A serious problem ?',
  'Current methods for the control of cattle tick Boophilus microplus infestations are not effective and the parasite remains a serious problem for the cattle industry in tropical and subtropical areas .',
  'Current methods for the control of the cattle tick Boophilus microplus infestations are not effective and the parasite remains a serious problem for the cattle industry in tropical and sub-tropical areas .',
  'Lyme Borreliosis is a serious diagnostical and therapeutical problem in regions with high exposure of residents to ticks , which are Borrelia burgdorferi vectors .',
  'Tick-borne illnesses pose a serious concern to human and veterinary health and their prevalence is on the rise .',
  'Tick-borne encephalitis virus ( TBEV ) is a severe problem in Estonia .',
  'The use of traditional control methods has been only partially successful and tick infestations remain a serious problem .',
  'Tick infestations and tick-borne diseases ( TBDs ) remain a serious and persistent problem , due to the lack of efficient control measures .',
  'Ticks parasitizing on reptiles are known as vectors of tick-borne diseases , which indicate a serious epidemic problem , created by the import of exotic reptiles to the territory of Poland .'],
 'ticks': ['Babesiosis, a tick-borne illness spread by Ixodes scapularis, is an emerging infectious disease in the Northeastern and upper Midwestern United States',
  'Ticks were not directly or indirectly implicated in any of 16 mortalities that occurred among 61 radio-collared fawns monitored for approximately 6 mo post-partum , and were not considered a serious health problem for fawns on the study area .',
  'Our studies indicate that Lyme borreliosis is a serious health problem among the inhabitants of Podlasie Province which is an endemic area for Ixodes ricinus ticks infected with B. burgdorferi spirochete .',
  'Despite efforts to control tick infestations , they remain a serious health problem .',
  'Ticks infesting cattle represent a serious problem for improvement of cattle productivity in   South Sudan .',
  'Lyme borreliosis has become a serious diagnostic and therapeutic problem of modern medicine .',
  'In the recent years , TBEV has become a serious public health problem with a steady increase in its incidence , mainly due to the climate changes and spreading the infected ticks into new territories .',
  'From tick bite to treatment , Lyme disease is a serious concern for those who reside in parts of the world where this infectious disorder is endemic .',
  'Lyme disease is a serious health problem , with many patients requiring in-depth clinical assessment and extended treatment .',
  'Despite efforts to control tick infestations , these ectoparasites remain a serious problem for human and animal health(4,5 ) .',
  'Tick-borne encephalitis ( TBE ) virus , which is usually divided into European , Far Eastern and Siberian subtypes , is a serious public health problem in several European and Asian countries .',
  'The cattle tick Boophilus microplus is a serious concern to the Brazilian cattle industry .',
  'New Babesia species have been identified globally , suggesting that the epidemiology of this disease is rapidly changing , making it clear that human babesiosis is a serious public health concern that requires close monitoring and effective intervention measures .',
  'The rapidly increasing incidence of Lyme disease has become a serious public health problem .',
  'Cattle tick control remains a serious problem for cattle farms in Brazil due to the limited success achieved with chemicals .',
  'The geographical expansion of the tick Ixodes ricinus in northern Europe is a serious concern for animal and human health .',
  'For each of 3 herd sizes of 250 , 500 and 1,000 cattle , comparisons were made of the costs of 4 different control options : ( i ) Intensive dipping ( 40 times/year ) ( ii ) Intensive pour-on acaricide treatments ( 18 times/year ) ( iii ) Theileria immunisation with strategic dipping ( 6 times/year ) ( iv ) Theileria immunisation with pour-on treatment ( 4 times/year ) It is concluded from these studies that , on farms where theileriosis is a serious problem , immunisation coupled with a strategic dipping programme is economically very attractive .',
  'Bovine theileriosis , a tick-borne protozoan disease caused by Theileria annulata , Theileria orientalis and Theileria sinensis , is widespread in China and is a serious economic problem for the Chinese livestock industry .',
  'Tick-borne encephalitis ( TBE ) is a severe problem in Lithuania , indicated by the 171 to 645 serologically confirmed cases that occurred each year between 1993 and 1999 .',
  'Tick-borne infections have been increasing steadily over the years , with co-infections with Borrelia burgdorferi and Babesia microti/divergens emerging as a serious health problem .',
  'Cattle tick control remains a serious problem in cattle farms worldwide , due to the limited success achieved with chemicals .',
  'The high incidence of Lyme borreliosis among the residents of endemic areas , along with diagnostic and therapeutic difficulties , make it a serious academic , clinical and social problem .',
  'Lyme disease in Poland - A serious problem ?',
  'Current methods for the control of cattle tick Boophilus microplus infestations are not effective and the parasite remains a serious problem for the cattle industry in tropical and subtropical areas .',
  'Current methods for the control of the cattle tick Boophilus microplus infestations are not effective and the parasite remains a serious problem for the cattle industry in tropical and sub-tropical areas .',
  'Lyme Borreliosis is a serious diagnostical and therapeutical problem in regions with high exposure of residents to ticks , which are Borrelia burgdorferi vectors .',
  'Tick-borne illnesses pose a serious concern to human and veterinary health and their prevalence is on the rise .',
  'Tick-borne encephalitis virus ( TBEV ) is a severe problem in Estonia .',
  'The use of traditional control methods has been only partially successful and tick infestations remain a serious problem .',
  'Tick infestations and tick-borne diseases ( TBDs ) remain a serious and persistent problem , due to the lack of efficient control measures .',
  'Ticks parasitizing on reptiles are known as vectors of tick-borne diseases , which indicate a serious epidemic problem , created by the import of exotic reptiles to the territory of Poland .'],
 'infestations': ['Babesiosis, a tick-borne illness spread by Ixodes scapularis, is an emerging infectious disease in the Northeastern and upper Midwestern United States',
  'Ticks were not directly or indirectly implicated in any of 16 mortalities that occurred among 61 radio-collared fawns monitored for approximately 6 mo post-partum , and were not considered a serious health problem for fawns on the study area .',
  'Our studies indicate that Lyme borreliosis is a serious health problem among the inhabitants of Podlasie Province which is an endemic area for Ixodes ricinus ticks infected with B. burgdorferi spirochete .',
  'Despite efforts to control tick infestations , they remain a serious health problem .',
  'Ticks infesting cattle represent a serious problem for improvement of cattle productivity in   South Sudan .',
  'Lyme borreliosis has become a serious diagnostic and therapeutic problem of modern medicine .',
  'In the recent years , TBEV has become a serious public health problem with a steady increase in its incidence , mainly due to the climate changes and spreading the infected ticks into new territories .',
  'From tick bite to treatment , Lyme disease is a serious concern for those who reside in parts of the world where this infectious disorder is endemic .',
  'Lyme disease is a serious health problem , with many patients requiring in-depth clinical assessment and extended treatment .',
  'Despite efforts to control tick infestations , these ectoparasites remain a serious problem for human and animal health(4,5 ) .',
  'Tick-borne encephalitis ( TBE ) virus , which is usually divided into European , Far Eastern and Siberian subtypes , is a serious public health problem in several European and Asian countries .',
  'The cattle tick Boophilus microplus is a serious concern to the Brazilian cattle industry .',
  'New Babesia species have been identified globally , suggesting that the epidemiology of this disease is rapidly changing , making it clear that human babesiosis is a serious public health concern that requires close monitoring and effective intervention measures .',
  'The rapidly increasing incidence of Lyme disease has become a serious public health problem .',
  'Cattle tick control remains a serious problem for cattle farms in Brazil due to the limited success achieved with chemicals .',
  'The geographical expansion of the tick Ixodes ricinus in northern Europe is a serious concern for animal and human health .',
  'For each of 3 herd sizes of 250 , 500 and 1,000 cattle , comparisons were made of the costs of 4 different control options : ( i ) Intensive dipping ( 40 times/year ) ( ii ) Intensive pour-on acaricide treatments ( 18 times/year ) ( iii ) Theileria immunisation with strategic dipping ( 6 times/year ) ( iv ) Theileria immunisation with pour-on treatment ( 4 times/year ) It is concluded from these studies that , on farms where theileriosis is a serious problem , immunisation coupled with a strategic dipping programme is economically very attractive .',
  'Bovine theileriosis , a tick-borne protozoan disease caused by Theileria annulata , Theileria orientalis and Theileria sinensis , is widespread in China and is a serious economic problem for the Chinese livestock industry .',
  'Tick-borne encephalitis ( TBE ) is a severe problem in Lithuania , indicated by the 171 to 645 serologically confirmed cases that occurred each year between 1993 and 1999 .',
  'Tick-borne infections have been increasing steadily over the years , with co-infections with Borrelia burgdorferi and Babesia microti/divergens emerging as a serious health problem .',
  'Cattle tick control remains a serious problem in cattle farms worldwide , due to the limited success achieved with chemicals .',
  'The high incidence of Lyme borreliosis among the residents of endemic areas , along with diagnostic and therapeutic difficulties , make it a serious academic , clinical and social problem .',
  'Lyme disease in Poland - A serious problem ?',
  'Current methods for the control of cattle tick Boophilus microplus infestations are not effective and the parasite remains a serious problem for the cattle industry in tropical and subtropical areas .',
  'Current methods for the control of the cattle tick Boophilus microplus infestations are not effective and the parasite remains a serious problem for the cattle industry in tropical and sub-tropical areas .',
  'Lyme Borreliosis is a serious diagnostical and therapeutical problem in regions with high exposure of residents to ticks , which are Borrelia burgdorferi vectors .',
  'Tick-borne illnesses pose a serious concern to human and veterinary health and their prevalence is on the rise .',
  'Tick-borne encephalitis virus ( TBEV ) is a severe problem in Estonia .',
  'The use of traditional control methods has been only partially successful and tick infestations remain a serious problem .',
  'Tick infestations and tick-borne diseases ( TBDs ) remain a serious and persistent problem , due to the lack of efficient control measures .',
  'Ticks parasitizing on reptiles are known as vectors of tick-borne diseases , which indicate a serious epidemic problem , created by the import of exotic reptiles to the territory of Poland .'],
 'theileria': ['Babesiosis, a tick-borne illness spread by Ixodes scapularis, is an emerging infectious disease in the Northeastern and upper Midwestern United States',
  'Ticks were not directly or indirectly implicated in any of 16 mortalities that occurred among 61 radio-collared fawns monitored for approximately 6 mo post-partum , and were not considered a serious health problem for fawns on the study area .',
  'Our studies indicate that Lyme borreliosis is a serious health problem among the inhabitants of Podlasie Province which is an endemic area for Ixodes ricinus ticks infected with B. burgdorferi spirochete .',
  'Despite efforts to control tick infestations , they remain a serious health problem .',
  'Ticks infesting cattle represent a serious problem for improvement of cattle productivity in   South Sudan .',
  'Lyme borreliosis has become a serious diagnostic and therapeutic problem of modern medicine .',
  'In the recent years , TBEV has become a serious public health problem with a steady increase in its incidence , mainly due to the climate changes and spreading the infected ticks into new territories .',
  'From tick bite to treatment , Lyme disease is a serious concern for those who reside in parts of the world where this infectious disorder is endemic .',
  'Lyme disease is a serious health problem , with many patients requiring in-depth clinical assessment and extended treatment .',
  'Despite efforts to control tick infestations , these ectoparasites remain a serious problem for human and animal health(4,5 ) .',
  'Tick-borne encephalitis ( TBE ) virus , which is usually divided into European , Far Eastern and Siberian subtypes , is a serious public health problem in several European and Asian countries .',
  'The cattle tick Boophilus microplus is a serious concern to the Brazilian cattle industry .',
  'New Babesia species have been identified globally , suggesting that the epidemiology of this disease is rapidly changing , making it clear that human babesiosis is a serious public health concern that requires close monitoring and effective intervention measures .',
  'The rapidly increasing incidence of Lyme disease has become a serious public health problem .',
  'Cattle tick control remains a serious problem for cattle farms in Brazil due to the limited success achieved with chemicals .',
  'The geographical expansion of the tick Ixodes ricinus in northern Europe is a serious concern for animal and human health .',
  'For each of 3 herd sizes of 250 , 500 and 1,000 cattle , comparisons were made of the costs of 4 different control options : ( i ) Intensive dipping ( 40 times/year ) ( ii ) Intensive pour-on acaricide treatments ( 18 times/year ) ( iii ) Theileria immunisation with strategic dipping ( 6 times/year ) ( iv ) Theileria immunisation with pour-on treatment ( 4 times/year ) It is concluded from these studies that , on farms where theileriosis is a serious problem , immunisation coupled with a strategic dipping programme is economically very attractive .',
  'Bovine theileriosis , a tick-borne protozoan disease caused by Theileria annulata , Theileria orientalis and Theileria sinensis , is widespread in China and is a serious economic problem for the Chinese livestock industry .',
  'Tick-borne encephalitis ( TBE ) is a severe problem in Lithuania , indicated by the 171 to 645 serologically confirmed cases that occurred each year between 1993 and 1999 .',
  'Tick-borne infections have been increasing steadily over the years , with co-infections with Borrelia burgdorferi and Babesia microti/divergens emerging as a serious health problem .',
  'Cattle tick control remains a serious problem in cattle farms worldwide , due to the limited success achieved with chemicals .',
  'The high incidence of Lyme borreliosis among the residents of endemic areas , along with diagnostic and therapeutic difficulties , make it a serious academic , clinical and social problem .',
  'Lyme disease in Poland - A serious problem ?',
  'Current methods for the control of cattle tick Boophilus microplus infestations are not effective and the parasite remains a serious problem for the cattle industry in tropical and subtropical areas .',
  'Current methods for the control of the cattle tick Boophilus microplus infestations are not effective and the parasite remains a serious problem for the cattle industry in tropical and sub-tropical areas .',
  'Lyme Borreliosis is a serious diagnostical and therapeutical problem in regions with high exposure of residents to ticks , which are Borrelia burgdorferi vectors .',
  'Tick-borne illnesses pose a serious concern to human and veterinary health and their prevalence is on the rise .',
  'Tick-borne encephalitis virus ( TBEV ) is a severe problem in Estonia .',
  'The use of traditional control methods has been only partially successful and tick infestations remain a serious problem .',
  'Tick infestations and tick-borne diseases ( TBDs ) remain a serious and persistent problem , due to the lack of efficient control measures .',
  'Ticks parasitizing on reptiles are known as vectors of tick-borne diseases , which indicate a serious epidemic problem , created by the import of exotic reptiles to the territory of Poland .'],
 'thyroid': ['The prevalence of autoimmune thyroiditis (AIT) and papillary thyroid carcinoma (PTC) is rising in children and adolescents, and the coincidence of AIT and PTC is as high as 6',
  'Anaplastic thyroid cancer/ATC is highly lethal malignancy without reliable chemotherapeutic drug',
  "The coexistence of functional thyroid nodules and Graves' disease (GD) is a rare condition known as Marine-Lenhart syndrome",
  'A major problem in the treatment of patients with congenital hypothyroidism ( CHT ) is that the optimal individual target values of thyrotropin ( TSH ) and free thyroxine ( fT(4 ) ) are unknown .',
  'A significant drawback of the radioisotopic scanning of the thyroid gland is the absence of a distinct knowledge of topographo-anatomical associations of this gland with other organs and tissues .',
  'The frequent use of levothyroxine suggests that TSH suppression could represent a serious public health concern , particularly for postmenopausal women and patients with heart disease .',
  'Although endocrine therapy , such as therapy with fulvestrant , is widely used in the clinic , endocrine resistance ( primary or secondary ) is inevitable and poses a serious clinical concern .',
  'Thyroid-associated ophthalmopathy remains a vexing medical problem , the pathogenesis of which remains uncertain .',
  'Isolated sphenoiditis occurs rarely but it still is a serious diagnostic and therapeutic problem .',
  'Patients refractory to steroids and/or splenectomy present with a serious therapeutic problem .',
  "Histologic findings occasionally can not distinguish lymphoma from Hashimoto 's thyroiditis , which creates a serious problem of whether treatment should be initiated .",
  'Autoimmune thyroid disease is a serious medical problem in which various operative procedures are performed .',
  'Permanent hypoparathyroidism is a serious problem and requires medications indefinitely .',
  'Properly treated endocrinological deficits need not be a serious problem , but persistent hyperosmolality carried a grave prognosis .',
  'Thus , primary or secondary malignant disease of the thyroid can simulate thyroiditis and present a serious problem in differential diagnosis .',
  'As the incidence of thyroid cancer has increased , hypocalcemia , a common complication of thyroid surgery , has become a serious problem .',
  'Detection of ectopic thyroid remnants : a serious diagnostic dilemma . When molecular biology and immunohistochemistry can solve the problem .',
  'Low thyroid reserve due to autoimmune thyroiditis is increasingly recognized as a serious health problem .',
  'This is a serious problem since , according to literature , 7 - 20 % of cold thyroid nodules are malignant .',
  "The most important of the extra-thyroidal manifestations of Graves ' disease , Graves ' orbitopathy ( GO ) , remains a vexing clinical problem .",
  'Hyperthyroid heart disease ( HHD ) , one of the most common complications of hyperthyroidism , is a serious public health problem due to the direct toxic or indirect effects of excessive thyroid hormone on the heart , resulting in high mortality and increasing health care costs .',
  'Amiodarone-induced thyrotoxicosis is a life-threatening problem that is very effectively managed by total thyroidectomy , although often many of these patients are considered " too unfit " for anaesthesia .',
  "The observation of a severe from of cardiotoxicosis in a patient with Plummer 's toxic thyroid adenoma has prompted the authors to make some considerations on the pathophysiology and clinical pattern of a type of pathology that is infrequent but clinically highly interesting .",
  'Resistance to steroid hormones presents a serious problem with respect to their mass use in therapy .',
  "In surgical treatment of hyperthyroidism , permanent laryngeal nerve paralysis may be reduced to less than 1 % , while hypoparathyroidism is still a severe problem in patients with Graves ' disease , and due to the necessity for an extensive operation is approximately 2 % in all cases ."],
 'thyroiditis': ['The prevalence of autoimmune thyroiditis (AIT) and papillary thyroid carcinoma (PTC) is rising in children and adolescents, and the coincidence of AIT and PTC is as high as 6',
  'Anaplastic thyroid cancer/ATC is highly lethal malignancy without reliable chemotherapeutic drug',
  "The coexistence of functional thyroid nodules and Graves' disease (GD) is a rare condition known as Marine-Lenhart syndrome",
  'A major problem in the treatment of patients with congenital hypothyroidism ( CHT ) is that the optimal individual target values of thyrotropin ( TSH ) and free thyroxine ( fT(4 ) ) are unknown .',
  'A significant drawback of the radioisotopic scanning of the thyroid gland is the absence of a distinct knowledge of topographo-anatomical associations of this gland with other organs and tissues .',
  'The frequent use of levothyroxine suggests that TSH suppression could represent a serious public health concern , particularly for postmenopausal women and patients with heart disease .',
  'Although endocrine therapy , such as therapy with fulvestrant , is widely used in the clinic , endocrine resistance ( primary or secondary ) is inevitable and poses a serious clinical concern .',
  'Thyroid-associated ophthalmopathy remains a vexing medical problem , the pathogenesis of which remains uncertain .',
  'Isolated sphenoiditis occurs rarely but it still is a serious diagnostic and therapeutic problem .',
  'Patients refractory to steroids and/or splenectomy present with a serious therapeutic problem .',
  "Histologic findings occasionally can not distinguish lymphoma from Hashimoto 's thyroiditis , which creates a serious problem of whether treatment should be initiated .",
  'Autoimmune thyroid disease is a serious medical problem in which various operative procedures are performed .',
  'Permanent hypoparathyroidism is a serious problem and requires medications indefinitely .',
  'Properly treated endocrinological deficits need not be a serious problem , but persistent hyperosmolality carried a grave prognosis .',
  'Thus , primary or secondary malignant disease of the thyroid can simulate thyroiditis and present a serious problem in differential diagnosis .',
  'As the incidence of thyroid cancer has increased , hypocalcemia , a common complication of thyroid surgery , has become a serious problem .',
  'Detection of ectopic thyroid remnants : a serious diagnostic dilemma . When molecular biology and immunohistochemistry can solve the problem .',
  'Low thyroid reserve due to autoimmune thyroiditis is increasingly recognized as a serious health problem .',
  'This is a serious problem since , according to literature , 7 - 20 % of cold thyroid nodules are malignant .',
  "The most important of the extra-thyroidal manifestations of Graves ' disease , Graves ' orbitopathy ( GO ) , remains a vexing clinical problem .",
  'Hyperthyroid heart disease ( HHD ) , one of the most common complications of hyperthyroidism , is a serious public health problem due to the direct toxic or indirect effects of excessive thyroid hormone on the heart , resulting in high mortality and increasing health care costs .',
  'Amiodarone-induced thyrotoxicosis is a life-threatening problem that is very effectively managed by total thyroidectomy , although often many of these patients are considered " too unfit " for anaesthesia .',
  "The observation of a severe from of cardiotoxicosis in a patient with Plummer 's toxic thyroid adenoma has prompted the authors to make some considerations on the pathophysiology and clinical pattern of a type of pathology that is infrequent but clinically highly interesting .",
  'Resistance to steroid hormones presents a serious problem with respect to their mass use in therapy .',
  "In surgical treatment of hyperthyroidism , permanent laryngeal nerve paralysis may be reduced to less than 1 % , while hypoparathyroidism is still a severe problem in patients with Graves ' disease , and due to the necessity for an extensive operation is approximately 2 % in all cases ."],
 'ventricular': ['Despite major advancements since its first description in the 19th century, infective endocarditis remains a significant medical challenge',
  'Left ventricle (LV) lipoma is a very rare, benign cardiac tumor',
  'Although a variety of strategies have been developed to enhance the structure and function of engineered cardiac tissues , an inherent limitation with traditional myocardial patches is that they do not permit evaluation of the fundamental relationships between pressure and volume that characterize global contractile function of the heart .',
  'The main problem with polymeric heart valves ( which are already biocompatible ) is that they usually fail in the long term owing to tearing and calcification of the leaflets under high dynamic tensile bending stress and oxidative reactions with blood .',
  'The most serious problem after mitral valve replacement with the ball valve prosthesis is that of thromboembolic complications .',
  'On one end of the spectrum is the pulmonary autograft , which comes closest to achieving these goals , but creates a double valve procedure for single valve disease , while on the other end are the mechanical valves and stented tissue valves , which allow easy " off the shelf " availability as well as easy implantability but are limited by the potential drawback of causing intrinsic obstruction to some extent because of the space occupied by the stent and sewing ring .',
  'These complications are a major safety drawback of TAVR when compared to surgical aortic valve replacement ( SAVR ) .',
  'A major drawback of the transcatheter aortic valve replacement ( TAVR ) procedure using the self-expandable Medtronic CoreValve ( MCV ) prosthesis is the high incidence of conduction disturbances and the need for postprocedural permanent pacemaker ( PPM ) implantation .',
  'Prolonged operative times , potentially leading to increased morbidity , are a possible drawback of minimally invasive aortic valve replacement .',
  'Life-threatening device failure of the HeartMate VE due to biologic inflow valve incompetence or motor failure is a major drawback of long-term mechanical support when using this left ventricular assist device ( LVAD ) .',
  'A major drawback of mechanical and prosthetic heart valves is their inability to permit somatic growth .',
  'After many decades of improvements in mechanical circulatory assist devices ( CADs ) , blood damage remains a serious problem during support contributing to variety of adverse events , and consequently affecting patient survival and quality of life .',
  'Despite improved diagnostic techniques and aggressive surgical therapy , infective endocarditis remains a serious problem associated with a high mortality in Khon Kaen .',
  'Heart valve disease is a serious and growing public health problem for which prosthetic replacement is most commonly indicated .',
  'Some patients may experience retrosternal pain during ERCP , which may be a pioneer of a serious myocardial problem , and early diagnosis is very important for the prognosis and management .',
  'Innovative design to prevent reversal of roller blood pump rotation in the event of electromechanical failure : an easy solution to a devastating problem .',
  'Although the management of truncal valve insufficiency has evolved over the years , approaches to this problem vary considerably and remain a serious dilemma in many cases .',
  'Left ventricular assist device ( LVAD ) thrombosis is a life-threatening complication that remains a major clinical problem .',
  'Myocarditis poses a severe health problem , can lead to dilated cardiomyopathy ( DCM ) and death , and is thought to be triggered by infections .',
  'Although right ventricular assist device ( RVAD ) use has declined with the introduction of inhaled nitric oxide and phosphodiesterase inhibitors ( type III ) , right ventricular dysfunction ( RVD ) is still a serious problem in patients receiving left ventricular assist devices ( LVAD ) .',
  'Endocarditis is a serious disease with a high in-hospital mortality and presents challenges in making an accurate diagnosis .',
  'Therefore , during extracorporeal membrane oxygenation ( ECMO ) treatment , the combination of a roller pump and an oxygenator with a high blood flow resistance will induce severe hemolysis , which is a serious problem .',
  'The development of RV failure in LVAD recipients is a serious problem associated with high mortality .',
  'Myocardial contusion is a serious problem not easily diagnosed .',
  'Heart valve repair or replacement is a serious problem .',
  'Heart valve repair or replacement is a serious problem .',
  'Diagnostic of chest pain in the emergency services supposes a serious problem .',
  'Calcific aortic valve stenosis ( CAVS ) is a serious clinical problem .',
  'Aortic regurgitation was observed or aggravated in 29 children ; at the end of the study , this remained a serious problem in 15 cases ( 17 % ) .',
  'Thromboembolism remains a serious problem in patients with prosthetic heart valves .',
  'Mitral regurgitation is a severe problem of the mitral valve mechanism caused by many factors , including ischemic and nonischemic cardiomyopathy , inflammation , degeneration and others .',
  'The ST- elevation myocardial infarction ( STEMI ) , a serious health care problem , is commonly a thrombotic complication of coronary artery disease .',
  'Bleeding remains a serious problem in patients with ventricular assist pumping ( VAP ) .',
  'Thrombotic obstruction of prosthetic valves is a serious problem .',
  'Although we have demonstrated successful formation of native valve analogous tissue in vitro , hemodynamic competence remains a serious problem .',
  'Ventricular septal rupture ( VSR ) complicating acute myocardial infarction ( AMI ) is a serious clinical problem with high mortality rate due to cardiogenic shock or prolonged hemodynamic compromise .',
  'Endocarditis remains a serious problem with high early mortality and morbidity .',
  'Right ventricular ( RV ) failure is a serious common clinical problem that is poorly understood .',
  'Right ventricular ( RV ) failure ( RVF ) is a vexing problem facing patients with various disease processes and carries a high mortality .',
  'Myocarditis is a serious and life-threatening illness , which can pose a significant diagnostic dilemma at presentation .',
  'Patients with chest pain of unexplained origin are a serious clinical problem .',
  'In Japan , paracorporeal pneumatic devices are the only choice for such therapy , as implantable LVADs are not yet generally available due to device lag , which represents a serious problem in this field .',
  'The differential diagnosis in relation to myocarditis is still a serious problem in cardiology : acute myocarditis is not a myocardiopathy , there exists , however , a close relationship between viral myocarditis and the development of dilatation cardiomyopathies .',
  'Although late endocarditis remains a serious problem , we believe that Marfan syndrome is a contraindication for valve sparing procedure .',
  'In developing centrifugal blood pumps , there has been a serious problem with hemolysis at the impeller or casing edge ; because of flow separation and turbulence in these regions .',
  'Iatrogenic right ventricular failure in tetralogy of Fallot repairs : reappraisal of a distressing problem .',
  'Ischemic mitral regurgitation ( IMR ) is a serious problem , which conveys adverse prognosis , doubling mortality after myocardial infarction .',
  'Rheumatic mitral regurgitation in the young remains a serious problem .',
  'However , heterogeneity between classification systems of mitral valve disease severity is a serious problem .',
  'Clinical applications of cardiac assist systems continue to have a severe problem , that of thromboembolic complications .',
  'Ventricular rupture following myocardial infarction is a serious clinical problem with a high mortality .',
  'Calcification of glutaraldehyde-preserved bioprosthetic cardiac valves represents a serious clinical problem .',
  'Though not very frequent , this is a serious concern because patients are high risk for surgical aortic valve replacement ( SAVR ) by definition , and explanting the endocarditic prosthetic valve followed by SAVR increases risk even higher .',
  'Chest pain , in particular , is a serious concern for patients and clinicians because of its potentially life-threatening implications -- misdiagnosis can be fatal .',
  'Right heart failure ( RHF ) is a vexing problem in children after left ventricular assist device ( LVAD ) implantation that can negatively impact transplant candidacy and survival .',
  'As an established , simple , inexpensive , and surprisingly effective diagnostic tool , right-heart contrast echocardiography ( RHCE ) might help in solving a vexing diagnostic problem .',
  'Calcification , the major cause of bioprosthetic heart valve failures , is a serious clinical problem with uncertain pathogenesis .',
  'TR after mitral valve replacement in rheumatic heart disease is a serious clinical problem .',
  'Biventricular failure and total artificial heart : Old and new solutions for a vexing problem .',
  'Aortic valve replacement in the young patient represents a serious problem in terms of anticoagulation and limited durability of the bioprosthesis .',
  'Acute chest pain represents a very common clinical occurrence and at the same time poses a severe diagnostic dilemma .',
  'Late cardiac complications may become a serious therapeutic problem .',
  'The discovery of an intracardial mass in patients presents a serious diagnostic dilemma .',
  'Myocarditis , which is the inflammation of the heart muscle , remains a vexing therapeutic problem .',
  'Calcification of bioprostheses used for heart valve replacement is a serious problem , since it causes bioprosthetic dysfunction .',
  'The patient posed a serious clinical dilemma whether to continue with surgery despite the type 2 myocardial infarction or postpone the surgery .',
  'It is certainly a serious problem , but early diagnosis and supporting angiography to rule out the presence of an associated left ventricular malformation and to check the volume of the left ventricular cavity should lead to a decision to operate .',
  'Stenosis of extracardiac conduit after reconstruction of right ventricle outflow tract is a serious problem , and the purpose of this study was to identify the suitability of broadly pedicled autologous pericardial flap for the reconstruction of pulmonary artery trunk in adult dogs .',
  'Left ventricular free wall rupture can be a catastrophic problem .'],
 'biliary': ['The prevalence of cholelithiasis in developed countries is high and its cause multifactorial, with a negligible proportion of drug-induced cholelithiasis',
  'However , a major drawback of MS is recurrent biliary obstruction ( RBO ) .',
  'A drawback of the bile acid dissolution therapy lies in a significant recurrence rate after treatment is discontinued .',
  'Episodic recurrence of jaundice and cholangitis due to stent occlusion is a major drawback of biliary polyethylene stents .',
  'The high rate of stone recurrence represents a drawback of non-surgical therapy of cholesterol gallstone disease .',
  'Cholecystolithiasis is a serious problem of contemporary medicine .',
  'The most common complications of this pathology are acute cholecystitis , choledocholithiasis , acute pancreatitis , retained common bile duct ( CBD ) stones , and gallbladder cancer ; these constitute a serious health problem in Chile .',
  'Gallbladder and biliary tract cancer is a serious clinical problem .',
  'However , biliary complications in RL-LDLT remain a serious problem : the incidence of anastomotic biliary leakage and stricture after RL-LDLT is reported to be 4.7%-18.2 % and 8.3%-31.7 % , respectively .',
  'Significant bile leak as an uncommon complication after biliary tract surgery may constitute a serious and difficult management problem .',
  'Biliary strictures following laparoscopic cholecystectomy ( Lap-C ) , which are often associated with vascular injuries , remain a serious problem to manage .',
  'Uncontrolled arterial bleeding during laparoscopic cholecystectomy is a serious problem and may increase the risk of bile duct damage .',
  'The Difficult Gallbladder : A Safe Approach to a Dangerous Problem .',
  'Postoperative bile leaks have been recognized to be a troublesome problem following laparoscopic cholecystectomy .',
  'Cancer of the gallbladder is a serious diagnostic and therapeutic problem .',
  'Thus , gallstone disease in childhood is becoming a serious medical and social problem because of its chronic relapsing course , the development of severe complications , reduced quality of life and social adaptation of children .',
  'Biliary atresia constitutes a serious problem in early infancy , due to the concomitant cholestasis .',
  'Biliary complications after orthotopic liver transplantation are still a severe problem and often require a second surgical operation .',
  'Biliary injury during laparoscopic cholecystectomy is still a serious problem .',
  'Gall-stone disease constitutes a serious clinical problem and is the most frequent cause of elective cholecystectomies .',
  'Obstructive jaundice caused by stenosis of the terminal choledochus remains even nowadays a serious differential diagnostic and therapeutic problem .',
  'Biliary injury during LC is still a serious problem .',
  'Biliary complications remain to pose a serious problem in patients after liver transplantation .',
  'Bile leakage after living donor liver transplantation ( LDLT ) remains a serious problem , resulting in lower survival rates .',
  'Biliary complications are a serious problem in patients after liver transplantation and often require reoperation .',
  'The management of symptomatic cholelithiasis during pregnancy remains a serious and difficult problem .',
  'Nevertheless , bile duct injuries and other post-cholecystectomy complications are a serious problem and a major cause of morbidity and mortality .',
  'In a previous study evaluating the problems of long-term percutaneous transhepatic biliary drainage ( PTBD ) using Yamakawa-type prostheses in patients with benign and malignant stenoses , breakage of the tube proved to be a serious problem , occurring in 19.7 % of PTBD exchanges .',
  'Polyps of the gall-bladder has long been a serious diagnostic problem .',
  'Uncontrolled arterial bleeding during laparoscopic cholecystectomy is a serious problem and may increase the risk of bile duct damage .',
  'Port-site metastasis following laparoscopic cholecystectomy with unsuspected gallbladder carcinoma is a serious problem .',
  'Acute cholecystitis ( AC ) may be a severe problem and may increase the mortality rate and hospital stay in patients who undergo open heart surgery ( OHS ) , due to its aggressive course ; therefore , AC should be treated as soon as possible .',
  'FTIR technique has helped analyze the complex components of bile stones , which persisted to be a vexing problem and causing high death rate in China .',
  'Uncontrolled bleeding from the cystic artery and its branches is a serious problem that may increase the risk of intraoperative lesions to vital vascular and biliary structures .',
  'In Chile , cholelithiasis is a serious public health problem and there are no studies about its natural history .',
  'Postoperative ascending cholangitis ( AC ) is a serious problem in patients with biliary atresia ( BA ) .',
  'Regardless of the application of the present methods , biliary ducts carcinoma remains a serious diagnostic and surgical problem .',
  'With 700,000 cholecystectomies performed in the US , annually , about 280,000 patients are left with symptoms , making this a serious problem .'],
 'cholecystectomy': ['The prevalence of cholelithiasis in developed countries is high and its cause multifactorial, with a negligible proportion of drug-induced cholelithiasis',
  'However , a major drawback of MS is recurrent biliary obstruction ( RBO ) .',
  'A drawback of the bile acid dissolution therapy lies in a significant recurrence rate after treatment is discontinued .',
  'Episodic recurrence of jaundice and cholangitis due to stent occlusion is a major drawback of biliary polyethylene stents .',
  'The high rate of stone recurrence represents a drawback of non-surgical therapy of cholesterol gallstone disease .',
  'Cholecystolithiasis is a serious problem of contemporary medicine .',
  'The most common complications of this pathology are acute cholecystitis , choledocholithiasis , acute pancreatitis , retained common bile duct ( CBD ) stones , and gallbladder cancer ; these constitute a serious health problem in Chile .',
  'Gallbladder and biliary tract cancer is a serious clinical problem .',
  'However , biliary complications in RL-LDLT remain a serious problem : the incidence of anastomotic biliary leakage and stricture after RL-LDLT is reported to be 4.7%-18.2 % and 8.3%-31.7 % , respectively .',
  'Significant bile leak as an uncommon complication after biliary tract surgery may constitute a serious and difficult management problem .',
  'Biliary strictures following laparoscopic cholecystectomy ( Lap-C ) , which are often associated with vascular injuries , remain a serious problem to manage .',
  'Uncontrolled arterial bleeding during laparoscopic cholecystectomy is a serious problem and may increase the risk of bile duct damage .',
  'The Difficult Gallbladder : A Safe Approach to a Dangerous Problem .',
  'Postoperative bile leaks have been recognized to be a troublesome problem following laparoscopic cholecystectomy .',
  'Cancer of the gallbladder is a serious diagnostic and therapeutic problem .',
  'Thus , gallstone disease in childhood is becoming a serious medical and social problem because of its chronic relapsing course , the development of severe complications , reduced quality of life and social adaptation of children .',
  'Biliary atresia constitutes a serious problem in early infancy , due to the concomitant cholestasis .',
  'Biliary complications after orthotopic liver transplantation are still a severe problem and often require a second surgical operation .',
  'Biliary injury during laparoscopic cholecystectomy is still a serious problem .',
  'Gall-stone disease constitutes a serious clinical problem and is the most frequent cause of elective cholecystectomies .',
  'Obstructive jaundice caused by stenosis of the terminal choledochus remains even nowadays a serious differential diagnostic and therapeutic problem .',
  'Biliary injury during LC is still a serious problem .',
  'Biliary complications remain to pose a serious problem in patients after liver transplantation .',
  'Bile leakage after living donor liver transplantation ( LDLT ) remains a serious problem , resulting in lower survival rates .',
  'Biliary complications are a serious problem in patients after liver transplantation and often require reoperation .',
  'The management of symptomatic cholelithiasis during pregnancy remains a serious and difficult problem .',
  'Nevertheless , bile duct injuries and other post-cholecystectomy complications are a serious problem and a major cause of morbidity and mortality .',
  'In a previous study evaluating the problems of long-term percutaneous transhepatic biliary drainage ( PTBD ) using Yamakawa-type prostheses in patients with benign and malignant stenoses , breakage of the tube proved to be a serious problem , occurring in 19.7 % of PTBD exchanges .',
  'Polyps of the gall-bladder has long been a serious diagnostic problem .',
  'Uncontrolled arterial bleeding during laparoscopic cholecystectomy is a serious problem and may increase the risk of bile duct damage .',
  'Port-site metastasis following laparoscopic cholecystectomy with unsuspected gallbladder carcinoma is a serious problem .',
  'Acute cholecystitis ( AC ) may be a severe problem and may increase the mortality rate and hospital stay in patients who undergo open heart surgery ( OHS ) , due to its aggressive course ; therefore , AC should be treated as soon as possible .',
  'FTIR technique has helped analyze the complex components of bile stones , which persisted to be a vexing problem and causing high death rate in China .',
  'Uncontrolled bleeding from the cystic artery and its branches is a serious problem that may increase the risk of intraoperative lesions to vital vascular and biliary structures .',
  'In Chile , cholelithiasis is a serious public health problem and there are no studies about its natural history .',
  'Postoperative ascending cholangitis ( AC ) is a serious problem in patients with biliary atresia ( BA ) .',
  'Regardless of the application of the present methods , biliary ducts carcinoma remains a serious diagnostic and surgical problem .',
  'With 700,000 cholecystectomies performed in the US , annually , about 280,000 patients are left with symptoms , making this a serious problem .'],
 'gallbladder': ['The prevalence of cholelithiasis in developed countries is high and its cause multifactorial, with a negligible proportion of drug-induced cholelithiasis',
  'However , a major drawback of MS is recurrent biliary obstruction ( RBO ) .',
  'A drawback of the bile acid dissolution therapy lies in a significant recurrence rate after treatment is discontinued .',
  'Episodic recurrence of jaundice and cholangitis due to stent occlusion is a major drawback of biliary polyethylene stents .',
  'The high rate of stone recurrence represents a drawback of non-surgical therapy of cholesterol gallstone disease .',
  'Cholecystolithiasis is a serious problem of contemporary medicine .',
  'The most common complications of this pathology are acute cholecystitis , choledocholithiasis , acute pancreatitis , retained common bile duct ( CBD ) stones , and gallbladder cancer ; these constitute a serious health problem in Chile .',
  'Gallbladder and biliary tract cancer is a serious clinical problem .',
  'However , biliary complications in RL-LDLT remain a serious problem : the incidence of anastomotic biliary leakage and stricture after RL-LDLT is reported to be 4.7%-18.2 % and 8.3%-31.7 % , respectively .',
  'Significant bile leak as an uncommon complication after biliary tract surgery may constitute a serious and difficult management problem .',
  'Biliary strictures following laparoscopic cholecystectomy ( Lap-C ) , which are often associated with vascular injuries , remain a serious problem to manage .',
  'Uncontrolled arterial bleeding during laparoscopic cholecystectomy is a serious problem and may increase the risk of bile duct damage .',
  'The Difficult Gallbladder : A Safe Approach to a Dangerous Problem .',
  'Postoperative bile leaks have been recognized to be a troublesome problem following laparoscopic cholecystectomy .',
  'Cancer of the gallbladder is a serious diagnostic and therapeutic problem .',
  'Thus , gallstone disease in childhood is becoming a serious medical and social problem because of its chronic relapsing course , the development of severe complications , reduced quality of life and social adaptation of children .',
  'Biliary atresia constitutes a serious problem in early infancy , due to the concomitant cholestasis .',
  'Biliary complications after orthotopic liver transplantation are still a severe problem and often require a second surgical operation .',
  'Biliary injury during laparoscopic cholecystectomy is still a serious problem .',
  'Gall-stone disease constitutes a serious clinical problem and is the most frequent cause of elective cholecystectomies .',
  'Obstructive jaundice caused by stenosis of the terminal choledochus remains even nowadays a serious differential diagnostic and therapeutic problem .',
  'Biliary injury during LC is still a serious problem .',
  'Biliary complications remain to pose a serious problem in patients after liver transplantation .',
  'Bile leakage after living donor liver transplantation ( LDLT ) remains a serious problem , resulting in lower survival rates .',
  'Biliary complications are a serious problem in patients after liver transplantation and often require reoperation .',
  'The management of symptomatic cholelithiasis during pregnancy remains a serious and difficult problem .',
  'Nevertheless , bile duct injuries and other post-cholecystectomy complications are a serious problem and a major cause of morbidity and mortality .',
  'In a previous study evaluating the problems of long-term percutaneous transhepatic biliary drainage ( PTBD ) using Yamakawa-type prostheses in patients with benign and malignant stenoses , breakage of the tube proved to be a serious problem , occurring in 19.7 % of PTBD exchanges .',
  'Polyps of the gall-bladder has long been a serious diagnostic problem .',
  'Uncontrolled arterial bleeding during laparoscopic cholecystectomy is a serious problem and may increase the risk of bile duct damage .',
  'Port-site metastasis following laparoscopic cholecystectomy with unsuspected gallbladder carcinoma is a serious problem .',
  'Acute cholecystitis ( AC ) may be a severe problem and may increase the mortality rate and hospital stay in patients who undergo open heart surgery ( OHS ) , due to its aggressive course ; therefore , AC should be treated as soon as possible .',
  'FTIR technique has helped analyze the complex components of bile stones , which persisted to be a vexing problem and causing high death rate in China .',
  'Uncontrolled bleeding from the cystic artery and its branches is a serious problem that may increase the risk of intraoperative lesions to vital vascular and biliary structures .',
  'In Chile , cholelithiasis is a serious public health problem and there are no studies about its natural history .',
  'Postoperative ascending cholangitis ( AC ) is a serious problem in patients with biliary atresia ( BA ) .',
  'Regardless of the application of the present methods , biliary ducts carcinoma remains a serious diagnostic and surgical problem .',
  'With 700,000 cholecystectomies performed in the US , annually , about 280,000 patients are left with symptoms , making this a serious problem .'],
 'herbal': ['Traditional Chinese medicine (TCM) is becoming increasingly popular and related adverse events are often ignored or underestimated',
  'The US National Center for Complementary and Alternative Medicine ( CAM ) defines CAM as " a group of diverse medical and health care systems , practices , and products that are not presently considered to be part of conventional medicine . " The problem with said therapies is that , for the most part , their effectiveness is questionable and their side effect profile is essentially unknown .',
  'The major limitation with herbal medicines is that the lack of standardization technique .',
  'Although this can be considered an advantage , the lack of a universal prescription for a specific disease is considered a drawback of traditional East Asian medicine .',
  'Based on literature review , this article provides a brief description of the Brazilian legislation policy regarding intellectual property and biodiversity access , places natural drug discovery in context , analyzes patent cases and highlights critical key issues responsible for the drawback of the whole process that has a direct impact on industrial and research development , nature protection and benefit share with our society .',
  'The adulteration of herbal medicines by dexamethasone or prednisolone is regarded as a serious problem in many communities .',
  'Herb-drug interactions are a serious problem especially for drugs with a narrow therapeutic index , taking into consideration that herbal medicines are commonly used in various parts of the world .',
  'Herb-drug interaction has become a serious problem since herbal medicine is extensively used in the modern world .',
  'Herb-drug interaction has become a serious problem since herbal medicine is extensively used in the modern world .',
  'Herb-drug interactions represent a serious problem as herbal medicine is used extensively in the modern world .',
  'For most complementary and alternative medicine interventions , the absence of a high-quality evidence base to define good practice presents a serious problem for clinicians , educators , and researchers .',
  'The existence of phenytoin products with different bioavailability is a serious practical problem which should be corrected as soon as possible .',
  'The adulteration of herbal medicinal products with synthetic drugs continues to be a serious problem for regulatory agencies .',
  'The adulteration or falsification of the cultivation age of mountain cultivated ginseng ( MCG ) has been a serious problem in the commercial MCG market .',
  'At present , there is a growing trend toward the intentional adulteration of dietary supplements ( DS ) with synthetic pharmaceuticals , which represents an alarming emerging risk to consumers and a serious problem for regulatory agencies .',
  'Adulteration of botanical dietary supplements with prohibited synthetic drugs has become a serious problem .',
  'PRACTICAL APPLICATIONS : The over or unwanted usage of synthetic medicine is a serious problem because it can cause so many adverse health effects .',
  'These issues not only pose a serious problem to the approvability of those botanical products as new drugs but also present as a limitation to their post-approval clinical use .',
  "The phenomenon of botanical dietary supplements ( BDS ) doped with illegal adulterants has become a serious problem all over the world , which could cause great threat to human 's health .",
  'Adulteration is a serious concern due to : ( i ) reduction in the efficacy of this traditional medicine , ( ii ) considerable health risk to consumers , and ( iii ) fraudulent product substitution that impacts the economy for the Natural Health Product ( NHP ) Industry and consumers .',
  'Ayurveda research publications : A serious concern .',
  'Ginseng is an important herbal resource worldwide , and the adulteration or falsification of cultivation age has been a serious problem in the commercial market .',
  'These aspects pose a serious problem for the final consumers of the pharmaceutical or nutraceutical products mainly related to the traceability of CS and to the declaration of the real origin of the active ingredient and its content .',
  'Due to this , herbal drug industry has started exploiting the situation and now Ayurvedic products are suffering from a serious problem of adulteration with addition of spoiled , inferior , spurious drugs that are inferior in therapeutic/chemical properties and used to enhance profits .',
  'As flavonoids are consumed in high content in our daily life , their potential to interfere with molybdenum hydroxylases could be a serious concern for consumer safety .',
  'Evidence from various countries implies that toxic heavy metals and undeclared prescription drugs in Asian herbal medicines might constitute a serious health problem .',
  'Drug-drug interactions have become a serious problem in the clinic , since plant-based medicines are extensively used .',
  'This variation causes a serious problem in standardizing the herbal extract .',
  'Ginseng roots are an important herbal resource worldwide , and the adulteration of ginseng with age is recognized as a serious problem .'],
 'scarcity': ['The lack of safe drinking water is a significant public health threat worldwide',
  'Shortage of freshwater is a serious problem in many regions worldwide , and is expected to become even more urgent over the next decades as a result of increased demand for food production and adverse effects of climate change .',
  'Water insecurity ( WI ) is a serious and worsening problem worldwide , but its role in health outcomes among people living with HIV or pregnant women is unknown .',
  'Water scarcity has become a serious problem in many parts of the world .',
  'Water scarcity is a serious problem that will be exacerbated by global climate change .',
  'Water shortage is a serious problem in many small island states , and many depend heavily on rainwater as the source of their water .',
  'The inability of the Government to budget and prioritise its budget poses a serious problem to meet the water demand , a few residents in peri-urban settlements use other sources of water , including groundwater .',
  'The headwater region of the Yellow River ( HRYR ) is one of the most important water supply areas of the whole river basin , which has suffered a serious water shortage problem for recent years .',
  'As the second largest inland river basin situated in the middle of the Hexi Corridor , Northwest China , the Heihe River basin ( HRB ) has been facing a severe water shortage problem , which seriously restricts its green and sustainable development .',
  "Our data show the risk of diseases spreading of water that the region 's population is exposed to the consumption of water , showing a serious public health problem .",
  'With acceleration of urbanization , water shortages will become a serious problem .',
  'Policy responses have concentrated on food needs , and it has often been difficult to mobilize resources for water interventions , despite evidence that access to safe water is a serious and interrelated concern .',
  'Water scarcity is a severe problem for regional environmental protection and socioeconomic development , and water footprints are effective tools for evaluating the magnitude of the water scarcity .',
  'However , heterogeneous density of rain gauge coverage , especially the sparse coverage over tropical continents , remains a serious concern .',
  'The majority perceives groundwater depletion to be a serious problem .',
  'Contaminated water is a serious concern in many developing countries with severe health consequences particularly for children .',
  'The scarceness of freshwater assets is a serious problem in semi-arid zones and marginal quality water is increasingly being used in agriculture .',
  'Declining groundwater levels is a serious problem in itself and has multiple economic , social , cultural , political , security-related , and environmental externalities .',
  'Poor water quality is a serious problem in the world which threatens human health , ecosystems , and plant/animal life .',
  'Overcrowding has become a serious concern in light of the acute water shortage that struck Freetown in May and June 2006 .',
  'Given the general consensus in the literature that recontamination of water from improved public sources is a severe public health problem , improved transport and storage technologies appear to be an effective low-cost supplement to the current standard of financing public water supply for poor rural communities .',
  'Inadequate water drinking is a serious problem in the school children .',
  'There is a serious concern regarding freshwater resources of Pakistan which have been mismanaged and now are depleting extensively due to other reasons like intensive application of agricultural pesticides and insecticides .',
  'Clean water provision remains a serious problem in low- and middle-income countries .',
  ', dwindling groundwater storage has emerged as a serious concern in recent years .',
  'Water scarcity is a serious environmental problem in many European regions , and will likely increase in the near future as a consequence of increased abstraction and climate change .',
  'The scarcity of freshwater resources is a serious problem in arid regions , such as Tunisia , and marginal quality water is gradually being used in agriculture .',
  'The availability and quality of irrigation water have become a serious concern because of global climate change and an increased competition for water by industry , domestic users and the environment .'],
 'hcc': ['Liver hepatocellular carcinoma (HCC) is one of the most malignant tumors, of which prognosis is unsatisfactory in most cases and metastatic of HCC often results in poor prognosis',
  'Hepatocellular carcinoma (HCC) is an epithelial cancer that originates from hepatocytes and it is the most common primary malignant tumor of the liver',
  'Primary Hepatic Epithelioid Hemangioendothelioma is an extremely rare tumor of vascular origin',
  'Radiofrequency ablation ( RFA ) for the treatment of small hepatocellular carcinoma ( HCC ) has a drawback of high recurrence rate .',
  'Hepatocellular carcinoma ( HCC ) is a serious health problem worldwide because of its association with hepatitis B and C viruses .',
  'Hepatocellular carcinoma ( HCC ) is a severe global health problem .',
  'Hepatocellular carcinoma is a serious health problem worldwide and is endemic in some areas because of its association with hepatitis B and C viruses ( in 20 % of cases ) .',
  'Reducing the incidence of hepatocellular carcinoma ( HCC ) in HIV-infected patients has become a serious problem when managing these patients .',
  'Treatment of liver malignancies , in particular hepatocellular carcinoma , remains a serious problem because of the difficulty of delivering adequate therapeutic agents to the lesions while sparing the surrounding normal tissue .',
  'It is also an important cause of hepatocellular carcinoma and is likely to remain a serious health problem resulting in substantial morbidity and mortality for several decades to come .',
  'A lack of effective prognostic biomarkers and molecular targets is a serious problem in hepatocellular carcinoma .',
  'Advanced hepatocellular carcinoma ( HCC ) is a serious public health problem , with no effective cure at present .',
  'Hepatocellular carcinoma ( HCC ) is increasingly known as a serious , worldwide public health concern .',
  'HCC is one of the main types of liver cancer , and has become a serious public health problem , due to its high incidence mainly in Southeast Asia and Africa .',
  'Hepatocellular carcinoma , ( HCC ) is a serious health problem .',
  'Hepatocellular carcinoma ( HCC ) is a primary malignant tumor of the liver that represents a serious public health problem all over the world , corresponding to the third cause of cancer death worldwide .',
  'Hepatocellular carcinoma ( HCC ) is a common cancer that affects people worldwide with high morbidity and mortality , and its resistance to current chemotherapeutic drugs is a serious concern .',
  'Hepatocellular carcinoma is a serious health problem worldwide , especially in Asian countries , such as China .',
  'The risk of such a serious side effect , likely related to a direct toxic effect of acetic acid , should be of concern when considering percutaneous treatment of hepatocellular carcinoma .',
  'Initial presentation of hepatocellular carcinoma ( HCC ) at an advanced stage in patients under a regular surveillance program is a devastating problem .',
  'Detection of hepatocellular carcinoma ( HCC ) in cirrhotic patients remains a serious , unsolved problem , and the risk factors for acute variceal bleeding ( AVB ) in HCC patients remain unclear .',
  'Local recurrence of hepatocellular carcinoma ( HCC ) after local ablation therapy ( LAT ) is a serious problem ; however , the optimal treatment strategy remains unclear .',
  'Radiofrequency ablation ( RFA ) and transarterial chemoembolization ( TACE ) have been applied for treating hepatocellular carcinoma ( HCC ) , but procedure-related complications can be a serious problem .'],
 'hepatocellular': ['Liver hepatocellular carcinoma (HCC) is one of the most malignant tumors, of which prognosis is unsatisfactory in most cases and metastatic of HCC often results in poor prognosis',
  'Hepatocellular carcinoma (HCC) is an epithelial cancer that originates from hepatocytes and it is the most common primary malignant tumor of the liver',
  'Primary Hepatic Epithelioid Hemangioendothelioma is an extremely rare tumor of vascular origin',
  'Radiofrequency ablation ( RFA ) for the treatment of small hepatocellular carcinoma ( HCC ) has a drawback of high recurrence rate .',
  'Hepatocellular carcinoma ( HCC ) is a serious health problem worldwide because of its association with hepatitis B and C viruses .',
  'Hepatocellular carcinoma ( HCC ) is a severe global health problem .',
  'Hepatocellular carcinoma is a serious health problem worldwide and is endemic in some areas because of its association with hepatitis B and C viruses ( in 20 % of cases ) .',
  'Reducing the incidence of hepatocellular carcinoma ( HCC ) in HIV-infected patients has become a serious problem when managing these patients .',
  'Treatment of liver malignancies , in particular hepatocellular carcinoma , remains a serious problem because of the difficulty of delivering adequate therapeutic agents to the lesions while sparing the surrounding normal tissue .',
  'It is also an important cause of hepatocellular carcinoma and is likely to remain a serious health problem resulting in substantial morbidity and mortality for several decades to come .',
  'A lack of effective prognostic biomarkers and molecular targets is a serious problem in hepatocellular carcinoma .',
  'Advanced hepatocellular carcinoma ( HCC ) is a serious public health problem , with no effective cure at present .',
  'Hepatocellular carcinoma ( HCC ) is increasingly known as a serious , worldwide public health concern .',
  'HCC is one of the main types of liver cancer , and has become a serious public health problem , due to its high incidence mainly in Southeast Asia and Africa .',
  'Hepatocellular carcinoma , ( HCC ) is a serious health problem .',
  'Hepatocellular carcinoma ( HCC ) is a primary malignant tumor of the liver that represents a serious public health problem all over the world , corresponding to the third cause of cancer death worldwide .',
  'Hepatocellular carcinoma ( HCC ) is a common cancer that affects people worldwide with high morbidity and mortality , and its resistance to current chemotherapeutic drugs is a serious concern .',
  'Hepatocellular carcinoma is a serious health problem worldwide , especially in Asian countries , such as China .',
  'The risk of such a serious side effect , likely related to a direct toxic effect of acetic acid , should be of concern when considering percutaneous treatment of hepatocellular carcinoma .',
  'Initial presentation of hepatocellular carcinoma ( HCC ) at an advanced stage in patients under a regular surveillance program is a devastating problem .',
  'Detection of hepatocellular carcinoma ( HCC ) in cirrhotic patients remains a serious , unsolved problem , and the risk factors for acute variceal bleeding ( AVB ) in HCC patients remain unclear .',
  'Local recurrence of hepatocellular carcinoma ( HCC ) after local ablation therapy ( LAT ) is a serious problem ; however , the optimal treatment strategy remains unclear .',
  'Radiofrequency ablation ( RFA ) and transarterial chemoembolization ( TACE ) have been applied for treating hepatocellular carcinoma ( HCC ) , but procedure-related complications can be a serious problem .'],
 'pollution': ['Air pollution is the largest environmental health risk in the United Kingdom, and an issue of concern amongst outdoor workers',
  'A problem with epidemiological studies is that the comparatively-small effect of air pollution is difficult to identify in the presence of larger and variable effects of cigarette smoking and other factors .',
  'With urbanization of coastal cities , marine pollution is becoming a severe problem .',
  'With the explosive economic development of China over the past few decades , air pollution has become a serious environmental problem and has attracted increasing global concern .',
  'Moreover , when working with highly productive waters , organic and inorganic particles pose a serious problem for cell recognition based on HISH-SIMS .',
  'Airborne pollution is a serious , and will be a major problem in Hong Kong within the next few years .',
  'A serious atmospheric contamination problem ( i.e. TSP ) exists in The Valley of Caracas .',
  'Pollution in rapidly urbanising cities and in delta systems is a serious problem that blights the lives and livelihoods of millions of people , damaging and restricting potable water supply and supplies to industry',
  'Although the RSA does not have a serious marine pollution problem , rapid population growth and increasing industrialization make it imperative to assess the pollution status of coastal waters and to plan for future developments .',
  'North Macedonia , as a developing country , has a serious problem with air pollution .',
  "Pollution of Florida 's waterways is a serious problem .",
  'Increasing ozone concentrations are becoming a severe problem for air pollution in China and have an adverse impact on human health .',
  'Air pollution is a serious environmental problem .',
  'Air pollution is a serious environmental problem in China .',
  'Air pollution has become a serious public health problem globally .',
  'Urban air quality is a serious problem , with an estimated 40 million people in Europe exposed to exceedences of existing WHO air-quality guidelines , with prospects of further declines in air quality due to projected growth in motor vehicle traffic .',
  'Due to the rapid development of industrial society , air pollution is becoming a serious problem which has being a huge threat to human health .',
  'Groundwater contamination is a serious problem that is growing in the United States , but its true extent is not known and it is difficult to determine because of the complexities of contaminants , their transformation , and fate in groundwater systems .',
  'Indoor air pollutant is a serious problem due to its wide diversity and variability .',
  'Air pollution has been identified as a serious problem throughout the world which causes tremendous loss to the crops by affecting plant growth and yield .',
  'The objective of this study was to investigate the environmental levels , emission sources , seasonal variations and health risk of eleven PAHs in the two cities , especially Ho Chi Minh City where air pollution is becoming a serious concern .',
  'Surface ozone is a severe air pollution problem in the North China Plain , which is home to 300 million people .',
  'Along with the rapid socioeconomic development , air pollution in China has become a severe problem .',
  'Transboundary transport of air pollution is a serious environmental concern as pollutant affects both human health and the environment .',
  'At the present time , ambient air pollution is a serious public health problem in China .',
  'Groundwater pollution from agricultural practices is a serious environmental and health problem .',
  'The occurrence of high ozone levels in the atmosphere of urban areas has become a serious pollution problem in a number of large cities in the world .',
  'In recent years , suspended particle pollution has become a serious problem in Taiwan .',
  'It has a serious air pollution problem mainly attributable to much industrial and commercial activity .',
  'Air pollution is a serious environmental problem in industrialized towns , where a significant portion of the residents live in close proximity to factories and major highways with high traffic load .',
  'These students lived in Ankara , which has a serious air pollution problem .',
  'Air pollution from road traffic is a serious public health problem .',
  'Air pollution in Santiago is a serious problem every winter , causing thousands of cases of breathing problems within the population .',
  'Air pollution has become a severe environmental problem due to urbanization and heavy traffic .',
  'Indoor air pollution by volatile organic compounds ( VOCs ) , which may cause a hazardous influence on human being such as sick building ( sick house ) syndrome , has become a serious problem .',
  'With fast economic growth , industrial water pollution has been a serious problem ubiquitously in China .',
  'Furthermore , air pollution also remains a serious concern in many global regions , requiring the application of appropriate treatment technologies to mitigate the respective negative effects on human health and environment .',
  'Air pollution is a serious health problem throughout the world , exacerbating a wide range of respiratory and vascular illnesses in urban areas .',
  'Air pollution is a serious environmental health problem that has been previously associated with neuropathological disorders .',
  'Urban air pollution is a serious worldwide problem due to its impact on human health .',
  'Ambient air pollution is becoming a serious environmental problem in China .',
  'In this research , Shenzhen City , which has a serious waterlogging problem , was used as a case study .',
  'However , environmental protection is also critical to realize a sustainable future , and water pollution is a serious problem of current society .',
  'Air pollution is a serious environmental problem .',
  'Air pollution is a serious problem in many countries in Southeast Asia , particularly in major metropolises with high levels of traffic congestion generating significant amounts of genotoxic substances .',
  'With the rapid development of China , water pollution is still a serious problem despite implementation of control measures .',
  'Air pollution has become a serious public health problem for many cities around the world .',
  'The air pollution in China is a severe problem .',
  'Air pollution in China is a serious problem and an inevitable threat to human health .',
  'Air pollution is a serious environmental health problem closely related to the occurrence of central nervous system diseases .',
  'At present , water pollution is still a serious problem in some parts of China .',
  'Groundwater contamination is becoming a serious problem in many Brazilian regions .',
  'Groundwater pollution is a serious problem in north China .',
  'Urban air quality is becoming a serious public health concern in China .',
  'Nowadays , a large number of health endpoints such as disease rates , treatment costs , and death , by air pollutants , have been a serious health problem for humans .',
  'Air pollution has become a serious problem in Beijing , China .',
  'There is a serious problem of water pollution in central Dhaka , in the Turag-Tongi-Balu River system in Bangladesh with the river system being one of the most polluted in the world at the moment .',
  'Air pollution is a serious health problem in almost all developing and developed countries around the world .',
  'The lack of sensors for low cost , extensive , and continuous detection of vapor pollutants is a serious concern for health and safety in industrialized urban areas .',
  'With dense population and rapid economic development of China , air pollution is still a serious problem and the prevalence of eczema has been elevating .',
  'Indoor Air Pollution ( IPA ) is a serious environmental problem that can have detrimental effects on child health .',
  'Water pollution is a serious problem in China .',
  'In crayfish ( Procambarus clarkii ) , the utility of redox proteomics as a novel biomarker was evaluated in the aquatic ecosystems of DNP and its surroundings , where agricultural activity is a serious concern .',
  'Traffic-related volatile organic compounds ( VOCs ) pollution has frequently been demonstrated to be a serious problem in the developing countries .',
  'Ambient air pollution and respiratory bacterial infections , a troubling association : epidemiology , underlying mechanisms , and future challenges .',
  "Air pollution is an important risk modifiable factor for dementia across the world , and the recent report of the Alzheimer 's disease continuum in children and young adults residing in Metropolitan Mexico City along with the presence of cognitive impairment in 55 % of the young adult population residing in Mexican cities with fine particulate matter concentrations above the current USEPA annual standard of 12 μg/m3 makes this a severe public health problem in progress .",
  'Athens has a serious air pollution problem which became evident in the early 1970s .',
  'Ozone ( O3 ) is a serious public health concern .',
  'Air pollution is a serious problem that affects billions of people globally .',
  'Pollutants from industrial sites and from municipal sewage treatment works ( STW ) entered the Elbe and led to a serious pollution problem in the river .',
  'Visibility degradation caused by air pollution has become a serious environmental problem in megacities in Northeast Asia .',
  'Air pollution is a serious public health concern worldwide , and cumulative evidence has revealed that air pollutants contribute to epigenetic variation in several genes , and this in turn can contribute to disease susceptibility .',
  "China 's lockdown to control COVID-19 brought significant declines in air pollutant emissions , but haze was still a serious problem in North China Plain ( NCP ) during late-January to mid-February of 2020 .",
  'Air pollution in cities is a serious environmental problem especially in the developing countries .',
  'Winter smog episodes are a severe problem in many cities around the world .',
  'Our results showed that due to the rapid urbanization and relocation of industrial plants from urban areas to rural areas in the past 20 years , air pollution in rural areas is becoming a serious problem in Shanghai and the Yangtze River delta .',
  'Pollution in the delta is increasingly recognized as a serious health concern that requires proper management of ecosystems .',
  'Outdoor air pollution is a serious problem in many developing countries today .',
  'Air pollution is a serious environmental problem that has drawn worldwide attention .',
  'Urban air pollution is a serious problem in both developing and developed countries , and antioxidant enzyme activities in plants have been suggested as a useful bioindicator of air pollution .',
  'Air pollution is a serious health problem in major cities in Mexico .',
  'Air pollution is a serious problem globally , especially in developing countries that causes health problems to humans and damage to the ecosystem .',
  'This can become a serious environmental problem , but specific impacts on groundwater are often overlooked in environmental impact assessments of CSPPs and no research on the matter has been reported so far .',
  'Although air pollution is a serious problem in Ahvaz , the association between air pollution and respiratory diseases has not been studied enough in this area .',
  'It is a well-known fact that the actual emission limits are very hard and there is arising a serious problem for automobile factories to meet the demanding emission requirements .',
  'With a growing awareness of environmental protection , the dust pollution caused by automobile foundry work has become a serious and urgent problem .',
  'Air pollution by nitrogen oxides represents a serious environmental problem in urban areas where numerous sources of these pollutants are concentrated .',
  'This is a serious problem because the air intake is the initial component of the ventilation plant and as such the first line of defense against debris and other outdoor air pollutants .',
  'Nowadays , air pollution by humans is considered a serious problem .',
  'Outdoor air pollution is a serious environmental problem worldwide .',
  'Sandy dust storms in Iraq represented a serious problem for human health , not only in Iraq but also extended to be in other countries .',
  'Environmental pollution still remains a serious problem in some heavily industrialized regions of Poland .',
  'Air pollution by nitrogen oxides represents a serious environmental problem in urban areas where numerous sources of these pollutants are concentrated .',
  'Groundwater pollution from anthropogenic sources is a serious concern affecting several coastal aquifers worldwide .',
  'Air pollution , which started to become a serious health concern with industrial revolution , has been threatening human health .',
  'With rapid economic development , air pollution became a serious problem in China .',
  'The groundwater quality of southwestern Punjab , India , is a serious cause of concern due to the presence of chemical contaminants in it .',
  'With the unprecedented urbanization during the past three decades , air quality in many Chinese cities has been a serious issue which poses great challenges for urban sustainability .',
  'Air pollution is a serious public health concern .',
  'In China groundwater contamination has become a serious problem .',
  'This is a serious concern , because O3 is a criteria air pollutant regulated by health-related federal and state standards .',
  'Water pollution is a serious problem in modern society .',
  'Rapid urban growth in Mediterranean cities has become a serious environmental concern .',
  'Exposure to ambient air pollution is a serious and common public health concern associated with growing morbidity and mortality worldwide .',
  'In China , regional haze pollution is a serious environmental problem .',
  'Water pollution caused by organic wastewater has become a serious concern worldwide .',
  'Blackwater events are frequently reported over the world and become a serious environmental problem .',
  'Water pollution is a serious environmental problem .',
  'Athens is a city with a serious air pollution problem which has existed for more than 20 years .',
  'They include , not limited to , a high level of heterogeneity , a very dry initial condition with low water saturation ( S(w ) ) , pollutants such as metals and radionuclides fully dissolved in groundwater , and a serious concern about downward migration during the remediation treatments .',
  'The deposition of pollutants on impervious surfaces is a serious problem associated with rapid urbanization , which results in non-point-source pollution .',
  'Deterioration of indoor air quality ( IAQ ) has become a serious concern as people spend lots of time indoors and prolonged pollution exposure can result in adverse health outcomes .',
  'Nowadays , air pollution is a severe environmental problem in China .',
  'Air pollution is a serious global health problem nowadays .',
  'Does ambient ozone pose a serious public health concern as a widespread environmental mutagen ?',
  'Water pollution from small rural industries is a serious problem throughout China .',
  'Due to intense industrialization and urbanization , air pollution has become a serious global concern as a hazard to human health .',
  'Groundwater pollution is a serious worldwide concern .',
  'Water pollution is a serious environmental problem affecting millions of people , and the demand for frequent water quality monitoring is increasing .',
  'It is evident from the past studies that dust fallout is a severe concern due to its impact to urban air quality and public health .',
  'Indoor air pollution ( IAP ) from solid fuels is a serious health problem in low-income countries that can be alleviated using improved stoves .',
  'Haze is a serious pollution problem during the wintertime in North China .',
  'Harmattan dust and traffic-related pollution have been a serious environmental concern in the West African sub-region .',
  'Air pollution is a serious environmental problem in China .',
  'Air pollution is a severe problem in major urban areas due to increasing numbers of vehicles , reduced road capacity and few investments in public transportation , especially in developing countries .',
  'Haze weather has become a serious environmental pollution problem which occurs in many Chinese cities .',
  'Urban air pollution is a serious environmental problem in developing countries worldwide , and health is a pressing issue in the megacities in Latin America .',
  'Air pollution is a severe public health problem in Taiwan .',
  'Air pollution is a severe problem in Poland , with Kraków area being among the regions with the worse air quality .',
  'Recurring biomass burning-induced smoke haze is a serious regional air pollution problem in Southeast Asia ( SEA ) .'],
 'sinusitis': ['Barotrauma to the middle-ear cavity and paranasal sinuses is a relatively common flight-related health problem',
  'Nasal liquorrhea is a serious problem in surgery of skull base tumors , which is associated with a high risk of purulent-septic complications .',
  'We conclude that purulent sinusitis represents a serious and often occult problem in already critically ill patients with multiple potential sources of sepsis .',
  'However intracranial complications of sinusitis are rare , but they are still a serious problem that results in high mortality .',
  'However intracranial complications of sinusitis are rare , but they are still a serious problem that results in high mortality .',
  'Cerebrospinal fluid ( CSF ) rhinorrhea is a dangerous problem .',
  'Sinus headaches are usually severely disabling migraines , misdiagnosed and mistreated , with 61 % of patients receiving antibiotic prescriptions for noninfectious causes , thus failing the patients and , in addition , contributing to a serious public health problem .',
  'With 6.25 % mortality and a high rate of functional sequelae , complications of sinusitis are a serious concern in our region .',
  'Complications of paranasal sinusitis still continue to be a serious health problem .',
  'The influence of the transseptal superior approach on the sinus node function in the mid-term postoperative period was apparently mild and did not cause a serious problem .',
  'Cerebrospinal fluid rhinorrhea , whatever the etiology , is a serious and life-threatening problem .',
  'Our series confirms that sinus-induced intracranial sepsis is a serious problem needing early diagnosis and aggressive treatment .'],
 'sinus': ['Barotrauma to the middle-ear cavity and paranasal sinuses is a relatively common flight-related health problem',
  'Nasal liquorrhea is a serious problem in surgery of skull base tumors , which is associated with a high risk of purulent-septic complications .',
  'We conclude that purulent sinusitis represents a serious and often occult problem in already critically ill patients with multiple potential sources of sepsis .',
  'However intracranial complications of sinusitis are rare , but they are still a serious problem that results in high mortality .',
  'However intracranial complications of sinusitis are rare , but they are still a serious problem that results in high mortality .',
  'Cerebrospinal fluid ( CSF ) rhinorrhea is a dangerous problem .',
  'Sinus headaches are usually severely disabling migraines , misdiagnosed and mistreated , with 61 % of patients receiving antibiotic prescriptions for noninfectious causes , thus failing the patients and , in addition , contributing to a serious public health problem .',
  'With 6.25 % mortality and a high rate of functional sequelae , complications of sinusitis are a serious concern in our region .',
  'Complications of paranasal sinusitis still continue to be a serious health problem .',
  'The influence of the transseptal superior approach on the sinus node function in the mid-term postoperative period was apparently mild and did not cause a serious problem .',
  'Cerebrospinal fluid rhinorrhea , whatever the etiology , is a serious and life-threatening problem .',
  'Our series confirms that sinus-induced intracranial sepsis is a serious problem needing early diagnosis and aggressive treatment .'],
 'rhinorrhea': ['Barotrauma to the middle-ear cavity and paranasal sinuses is a relatively common flight-related health problem',
  'Nasal liquorrhea is a serious problem in surgery of skull base tumors , which is associated with a high risk of purulent-septic complications .',
  'We conclude that purulent sinusitis represents a serious and often occult problem in already critically ill patients with multiple potential sources of sepsis .',
  'However intracranial complications of sinusitis are rare , but they are still a serious problem that results in high mortality .',
  'However intracranial complications of sinusitis are rare , but they are still a serious problem that results in high mortality .',
  'Cerebrospinal fluid ( CSF ) rhinorrhea is a dangerous problem .',
  'Sinus headaches are usually severely disabling migraines , misdiagnosed and mistreated , with 61 % of patients receiving antibiotic prescriptions for noninfectious causes , thus failing the patients and , in addition , contributing to a serious public health problem .',
  'With 6.25 % mortality and a high rate of functional sequelae , complications of sinusitis are a serious concern in our region .',
  'Complications of paranasal sinusitis still continue to be a serious health problem .',
  'The influence of the transseptal superior approach on the sinus node function in the mid-term postoperative period was apparently mild and did not cause a serious problem .',
  'Cerebrospinal fluid rhinorrhea , whatever the etiology , is a serious and life-threatening problem .',
  'Our series confirms that sinus-induced intracranial sepsis is a serious problem needing early diagnosis and aggressive treatment .'],
 'paranasal': ['Barotrauma to the middle-ear cavity and paranasal sinuses is a relatively common flight-related health problem',
  'Nasal liquorrhea is a serious problem in surgery of skull base tumors , which is associated with a high risk of purulent-septic complications .',
  'We conclude that purulent sinusitis represents a serious and often occult problem in already critically ill patients with multiple potential sources of sepsis .',
  'However intracranial complications of sinusitis are rare , but they are still a serious problem that results in high mortality .',
  'However intracranial complications of sinusitis are rare , but they are still a serious problem that results in high mortality .',
  'Cerebrospinal fluid ( CSF ) rhinorrhea is a dangerous problem .',
  'Sinus headaches are usually severely disabling migraines , misdiagnosed and mistreated , with 61 % of patients receiving antibiotic prescriptions for noninfectious causes , thus failing the patients and , in addition , contributing to a serious public health problem .',
  'With 6.25 % mortality and a high rate of functional sequelae , complications of sinusitis are a serious concern in our region .',
  'Complications of paranasal sinusitis still continue to be a serious health problem .',
  'The influence of the transseptal superior approach on the sinus node function in the mid-term postoperative period was apparently mild and did not cause a serious problem .',
  'Cerebrospinal fluid rhinorrhea , whatever the etiology , is a serious and life-threatening problem .',
  'Our series confirms that sinus-induced intracranial sepsis is a serious problem needing early diagnosis and aggressive treatment .'],
 'ischemic': ['Myocardial ischemia-reperfusion injury (MI-RI) has many adverse complications with high mortality rate',
  'A drawback of pre-existing in vitro models is that since susceptibility to ischemic injury is age-dependent ; neuroprotection is being studied in neurons that have intrinsic resistance to oxygen-glucose deprivation ( OGD ) .',
  'Limited coverage of the brain in the z-axis has been a drawback of perfusion CT .',
  'Although ischemic postconditioning ( IPost ) confers cardioprotection by protecting the mitochondria though the activation of phosphatidylinositol 3-kinase ( PI3 K ) , a potential drawback of IPost is impairment of aerobic ATP generation during reperfusion by repeated ischemia .',
  'Ischemia-reperfusion injury ( IRI ) is a severe problem \xa0 patients diagnosed with acute limb ischemia .',
  'Reperfusion injury is a serious problem in ischemic stroke therapy , which leads to neuronal damage and intracranial hemorrhage ( ICH ) .',
  'Ischemia-reperfusion ( I-R ) injury is a serious problem caused by vascular trauma , tourniquet use and/or compartment syndrome .',
  'Unfortunately , the cerebral re-perfusion syndrome is still a serious and not completely solved problem .',
  'Myocardial ischemia/reperfusion injury is a serious problem involved in cardiovascular diseases .',
  'Because it is a severe and complex problem , several studies have been done aiming to elucidate the mechanisms of the ischemic phenomenon and aiming to abolish or to diminish its effects , using drugs that protect the neurons from ischaemia-induced damage .',
  'Ischemia-reperfusion (I/R)-induced organ injury is a serious health problem worldwide , and poor recovery of acute phase injury leads to chronic fibrosis and further organ dysfunction .',
  'Reperfusion injury is a troublesome and unresolved problem in acute myocardial infarction and is believed to be associated with inflammatory reactions in which various types of cells and cytokines participate , in particular , macrophages and monocyte chemoattractant protein-1 ( MCP-1 ) .',
  'Cell therapy is a potential therapeutic method for cerebral ischemia , which remains a serious problem .',
  'Cerebral ischemia/reperfusion injury is a severe problem in patients with brain ischemia .',
  'BACKGROUND Cerebral ischemia-reperfusion injury ( CIRI ) remains a serious health problem .',
  'Ischemia-reperfusion ( I/R ) injury of the heart as a consequence of myocardial infarction or cardiac surgery represents a serious clinical problem .',
  'Ischemia-reperfusion injury is a serious problem .',
  "Vascular insufficiency of the child 's brain is a serious problem because perfusion can be disturbed sufficiently enough to cause permanent brain changes with extensive neurological deficit resulting in some .",
  'Cerebral ischemia-reperfusion ( IR ) has attracted wide attention as a serious clinical problem .',
  'Ischemia/reperfusion ( I/R ) injury is a serious problem resulting from clinical setting of coronary revascularization .',
  'Ischemia/reperfusion (I/R)-induced oxidative stress is a serious clinical problem in the reperfusion therapy for ischemic diseases .',
  "Cerebral ischemia-reperfusion ( I/R ) injury is also a serious problem for patients ' outcomes .",
  'Ischemic reperfusion ( I/R ) injury is a serious problem in the treatment of ischemic heart disease .',
  'In particularly , hippocampal injury after ischemia-reperfusion is a serious problem as it contributes to vascular dementia .',
  'Ischemia is a serious problem in clinical medicine , and effective methods are needed to detect ischemia before the injury becomes irreversible .',
  'Unfortunately , cerebral re-perfusion syndrome is a serious unresolved problem .',
  'In many reconstructive surgical procedures involving microsurgery and prolonged tissue ischemia time , IRI-induced skeletal-muscle injury is a serious clinical concern .',
  'Ischemia-reperfusion injury ( IRI ) has been recognized as a serious problem for therapy of cardiovascular diseases .',
  'Inflammatory response that occur post-ischemia is a serious problem in the treatment of ischemic brain disease .'],
 'myocardial': ['Myocardial ischemia-reperfusion injury (MI-RI) has many adverse complications with high mortality rate',
  'Although ischemic postconditioning ( IPost ) confers cardioprotection by protecting the mitochondria though the activation of phosphatidylinositol 3-kinase ( PI3 K ) , a potential drawback of IPost is impairment of aerobic ATP generation during reperfusion by repeated ischemia .',
  'Ischemia-reperfusion injury ( IRI ) is a severe problem \xa0 patients diagnosed with acute limb ischemia .',
  'Ischemia-reperfusion ( I-R ) injury is a serious problem caused by vascular trauma , tourniquet use and/or compartment syndrome .',
  'Myocardial ischemia/reperfusion injury is a serious problem involved in cardiovascular diseases .',
  'Ischemia-reperfusion (I/R)-induced organ injury is a serious health problem worldwide , and poor recovery of acute phase injury leads to chronic fibrosis and further organ dysfunction .',
  'Reperfusion injury is a troublesome and unresolved problem in acute myocardial infarction and is believed to be associated with inflammatory reactions in which various types of cells and cytokines participate , in particular , macrophages and monocyte chemoattractant protein-1 ( MCP-1 ) .',
  'Ischemia-reperfusion ( I/R ) injury of the heart as a consequence of myocardial infarction or cardiac surgery represents a serious clinical problem .',
  'Ischemia-reperfusion injury is a serious problem .',
  'Ischemia/reperfusion ( I/R ) injury is a serious problem resulting from clinical setting of coronary revascularization .',
  'Ischemia/reperfusion (I/R)-induced oxidative stress is a serious clinical problem in the reperfusion therapy for ischemic diseases .',
  'Ischemic reperfusion ( I/R ) injury is a serious problem in the treatment of ischemic heart disease .',
  'In many reconstructive surgical procedures involving microsurgery and prolonged tissue ischemia time , IRI-induced skeletal-muscle injury is a serious clinical concern .',
  'Ischemia-reperfusion injury ( IRI ) has been recognized as a serious problem for therapy of cardiovascular diseases .'],
 'genetic': ['Chromosome 15q24 microdeletion syndrome is a rare disease',
  "We also identify cases posing particular problems for genetic counselling , such as , ' homozygosity ' that can pose a serious ethical dilemma , carriers of large normal alleles , and ' homoallelism ' for a normal gene , which will demand further procedures and may delay results in presymptomatic and prenatal testing .",
  'Some believe PS does not represent a serious concern , whereas others believe that PS may contribute to contradictory findings in genetic association .',
  'This creates a serious problem in the genetic counseling and diagnosis of MLD .',
  'Unfortunately , our results question some disease-related genotyping analyses , raising a worrisome concern on their validity .',
  'At present , the little correlation that seems to exist between these different genotypes and the severity of the disease poses a serious dilemma for genetic counselors .',
  'The failure to replicate a postulated linkage has become a serious problem in studies on the genetics of complex disorders .',
  'Consanguinity is a serious concern that leads to the high prevalence of recessive disorders in the Middle East and North Africa and possibly other regions .',
  'Limitation of family size after the birth of a child with a serious disorder poses a problem in demonstrating autosomal recessive inheritance .',
  'The rapidly increasing number of mutations responsible for clinical and enzymological phenotypes and the very large number of statistically possible combinations among them for compound heterozygosity pose a serious pragmatic problem for classification and nomenclature of this group of rare genetic disorders .',
  'Heterogeneity , both inter- and intrafamilial , represents a serious problem in linkage studies of common complex diseases .'],
 'recessive': ['Chromosome 15q24 microdeletion syndrome is a rare disease',
  "We also identify cases posing particular problems for genetic counselling , such as , ' homozygosity ' that can pose a serious ethical dilemma , carriers of large normal alleles , and ' homoallelism ' for a normal gene , which will demand further procedures and may delay results in presymptomatic and prenatal testing .",
  'Some believe PS does not represent a serious concern , whereas others believe that PS may contribute to contradictory findings in genetic association .',
  'This creates a serious problem in the genetic counseling and diagnosis of MLD .',
  'Unfortunately , our results question some disease-related genotyping analyses , raising a worrisome concern on their validity .',
  'At present , the little correlation that seems to exist between these different genotypes and the severity of the disease poses a serious dilemma for genetic counselors .',
  'The failure to replicate a postulated linkage has become a serious problem in studies on the genetics of complex disorders .',
  'Consanguinity is a serious concern that leads to the high prevalence of recessive disorders in the Middle East and North Africa and possibly other regions .',
  'Limitation of family size after the birth of a child with a serious disorder poses a problem in demonstrating autosomal recessive inheritance .',
  'The rapidly increasing number of mutations responsible for clinical and enzymological phenotypes and the very large number of statistically possible combinations among them for compound heterozygosity pose a serious pragmatic problem for classification and nomenclature of this group of rare genetic disorders .',
  'Heterogeneity , both inter- and intrafamilial , represents a serious problem in linkage studies of common complex diseases .'],
 'fatty': ['Non-alcoholic fatty liver disease (NAFLD) is currently one of the most common chronic liver diseases especially in developed countries',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a chronic liver disease and is a serious global health problem .',
  'The pathways of chronic inflammation are well illustrated by nonalcoholic steatohepatitis ( NASH ) , which is of a serious concern due to its increasing prevalence in the westernized world and its direct correlation with lifestyle factors , particularly diet .',
  'Consequently , obesity and associated disorders such as nonalcoholic fatty liver disease constitute a serious problem .',
  'Approximately 25 % of the adult general population is suffering from nonalcoholic fatty liver disease ( NAFLD ) , which has become a serious health problem .',
  'Nonalcoholic fatty liver disease ( NAFLD ) has become a serious public health problem worldwide ; however , the availability of information on the prevalence of NAFLD in the general pediatric population is still limited .',
  'One form of liver steatosis , namely Non-Alcoholic Fatty Liver Disease ( NAFLD ) , is a worrisome health problem worldwide characterized by intrahepatic triacylglycerol ( TG ) overaccumulation .',
  'Fatty liver disease ( FLD ) , associated with chronic alcohol consumption or obesity , is a serious medical problem .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious health problem affecting ~25 % of the global population .',
  'Nonalcoholic steatohepatitis ( NASH ) is a serious and rapidly growing problem affecting a population that was not previously recognized as high risk .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is now the most frequent chronic liver disease that occurs across all age groups and is recognized to occur in 14%-30 % of the general population , representing a serious and growing clinical problem due to the growing prevalence of obesity and overweight .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious public health concern that affects almost one third of the US population .',
  'Non-alcoholic steatohepatitis ( NASH ) is the most severe form of non-alcoholic fatty liver disease and is a serious public health problem around the world .',
  'Fatty liver disease associated with chronic alcohol consumption or obesity/type 2 diabetes has emerged as a serious public health problem .',
  'Non-alcoholic fatty liver disease is a serious health problem linked to obesity and type 2 diabetes .',
  'To date , no approved drugs are available for the treatment of NAFLD , despite the fact that it represents a serious and growing clinical problem in the Western world .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious health concern in China .',
  'Fatty liver disease is a serious health problem worldwide and is the most common cause for chronic liver disease and metabolic disorders .',
  'The non-alcoholic fatty liver disease ( NAFLD ) has become a serious medical problem and an increasing threat to public health .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious public health problem .',
  'Non-alcoholic fatty liver disease is a serious and growing clinical problem .',
  'Currently , fatty liver represents a serious public health problem in the Western world .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious global public health concern .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is one of the most frequent causes of liver disease and its prevalence is a serious and growing clinical problem .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious health problem in developed countries .',
  'Non-alcoholic steatohepatitis ( NASH ) has become a serious public health problem associated with metabolic syndrome .',
  'Alcoholic and non-alcoholic fatty liver diseases have become a serious concern whole over the world .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious health problem .',
  'The progression in nonalcoholic fatty liver disease ( NAFLD ) to nonalcoholic steatohepatitis is a serious health concern , but the underlying mechanisms remain unclear .'],
 'alcoholic': ['Non-alcoholic fatty liver disease (NAFLD) is currently one of the most common chronic liver diseases especially in developed countries',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a chronic liver disease and is a serious global health problem .',
  'The pathways of chronic inflammation are well illustrated by nonalcoholic steatohepatitis ( NASH ) , which is of a serious concern due to its increasing prevalence in the westernized world and its direct correlation with lifestyle factors , particularly diet .',
  'Consequently , obesity and associated disorders such as nonalcoholic fatty liver disease constitute a serious problem .',
  'Approximately 25 % of the adult general population is suffering from nonalcoholic fatty liver disease ( NAFLD ) , which has become a serious health problem .',
  'Nonalcoholic fatty liver disease ( NAFLD ) has become a serious public health problem worldwide ; however , the availability of information on the prevalence of NAFLD in the general pediatric population is still limited .',
  'One form of liver steatosis , namely Non-Alcoholic Fatty Liver Disease ( NAFLD ) , is a worrisome health problem worldwide characterized by intrahepatic triacylglycerol ( TG ) overaccumulation .',
  'Fatty liver disease ( FLD ) , associated with chronic alcohol consumption or obesity , is a serious medical problem .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious health problem affecting ~25 % of the global population .',
  'Nonalcoholic steatohepatitis ( NASH ) is a serious and rapidly growing problem affecting a population that was not previously recognized as high risk .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is now the most frequent chronic liver disease that occurs across all age groups and is recognized to occur in 14%-30 % of the general population , representing a serious and growing clinical problem due to the growing prevalence of obesity and overweight .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious public health concern that affects almost one third of the US population .',
  'Non-alcoholic steatohepatitis ( NASH ) is the most severe form of non-alcoholic fatty liver disease and is a serious public health problem around the world .',
  'Fatty liver disease associated with chronic alcohol consumption or obesity/type 2 diabetes has emerged as a serious public health problem .',
  'Non-alcoholic fatty liver disease is a serious health problem linked to obesity and type 2 diabetes .',
  'To date , no approved drugs are available for the treatment of NAFLD , despite the fact that it represents a serious and growing clinical problem in the Western world .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious health concern in China .',
  'Fatty liver disease is a serious health problem worldwide and is the most common cause for chronic liver disease and metabolic disorders .',
  'The non-alcoholic fatty liver disease ( NAFLD ) has become a serious medical problem and an increasing threat to public health .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious public health problem .',
  'Non-alcoholic fatty liver disease is a serious and growing clinical problem .',
  'Currently , fatty liver represents a serious public health problem in the Western world .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious global public health concern .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is one of the most frequent causes of liver disease and its prevalence is a serious and growing clinical problem .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious health problem in developed countries .',
  'Non-alcoholic steatohepatitis ( NASH ) has become a serious public health problem associated with metabolic syndrome .',
  'Alcoholic and non-alcoholic fatty liver diseases have become a serious concern whole over the world .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious health problem .',
  'The progression in nonalcoholic fatty liver disease ( NAFLD ) to nonalcoholic steatohepatitis is a serious health concern , but the underlying mechanisms remain unclear .'],
 'nonalcoholic': ['Non-alcoholic fatty liver disease (NAFLD) is currently one of the most common chronic liver diseases especially in developed countries',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a chronic liver disease and is a serious global health problem .',
  'The pathways of chronic inflammation are well illustrated by nonalcoholic steatohepatitis ( NASH ) , which is of a serious concern due to its increasing prevalence in the westernized world and its direct correlation with lifestyle factors , particularly diet .',
  'Consequently , obesity and associated disorders such as nonalcoholic fatty liver disease constitute a serious problem .',
  'Approximately 25 % of the adult general population is suffering from nonalcoholic fatty liver disease ( NAFLD ) , which has become a serious health problem .',
  'Nonalcoholic fatty liver disease ( NAFLD ) has become a serious public health problem worldwide ; however , the availability of information on the prevalence of NAFLD in the general pediatric population is still limited .',
  'One form of liver steatosis , namely Non-Alcoholic Fatty Liver Disease ( NAFLD ) , is a worrisome health problem worldwide characterized by intrahepatic triacylglycerol ( TG ) overaccumulation .',
  'Fatty liver disease ( FLD ) , associated with chronic alcohol consumption or obesity , is a serious medical problem .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious health problem affecting ~25 % of the global population .',
  'Nonalcoholic steatohepatitis ( NASH ) is a serious and rapidly growing problem affecting a population that was not previously recognized as high risk .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is now the most frequent chronic liver disease that occurs across all age groups and is recognized to occur in 14%-30 % of the general population , representing a serious and growing clinical problem due to the growing prevalence of obesity and overweight .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious public health concern that affects almost one third of the US population .',
  'Non-alcoholic steatohepatitis ( NASH ) is the most severe form of non-alcoholic fatty liver disease and is a serious public health problem around the world .',
  'Fatty liver disease associated with chronic alcohol consumption or obesity/type 2 diabetes has emerged as a serious public health problem .',
  'Non-alcoholic fatty liver disease is a serious health problem linked to obesity and type 2 diabetes .',
  'To date , no approved drugs are available for the treatment of NAFLD , despite the fact that it represents a serious and growing clinical problem in the Western world .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious health concern in China .',
  'Fatty liver disease is a serious health problem worldwide and is the most common cause for chronic liver disease and metabolic disorders .',
  'The non-alcoholic fatty liver disease ( NAFLD ) has become a serious medical problem and an increasing threat to public health .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious public health problem .',
  'Non-alcoholic fatty liver disease is a serious and growing clinical problem .',
  'Currently , fatty liver represents a serious public health problem in the Western world .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious global public health concern .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is one of the most frequent causes of liver disease and its prevalence is a serious and growing clinical problem .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious health problem in developed countries .',
  'Non-alcoholic steatohepatitis ( NASH ) has become a serious public health problem associated with metabolic syndrome .',
  'Alcoholic and non-alcoholic fatty liver diseases have become a serious concern whole over the world .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious health problem .',
  'The progression in nonalcoholic fatty liver disease ( NAFLD ) to nonalcoholic steatohepatitis is a serious health concern , but the underlying mechanisms remain unclear .'],
 'steatohepatitis': ['Non-alcoholic fatty liver disease (NAFLD) is currently one of the most common chronic liver diseases especially in developed countries',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a chronic liver disease and is a serious global health problem .',
  'The pathways of chronic inflammation are well illustrated by nonalcoholic steatohepatitis ( NASH ) , which is of a serious concern due to its increasing prevalence in the westernized world and its direct correlation with lifestyle factors , particularly diet .',
  'Consequently , obesity and associated disorders such as nonalcoholic fatty liver disease constitute a serious problem .',
  'Approximately 25 % of the adult general population is suffering from nonalcoholic fatty liver disease ( NAFLD ) , which has become a serious health problem .',
  'Nonalcoholic fatty liver disease ( NAFLD ) has become a serious public health problem worldwide ; however , the availability of information on the prevalence of NAFLD in the general pediatric population is still limited .',
  'One form of liver steatosis , namely Non-Alcoholic Fatty Liver Disease ( NAFLD ) , is a worrisome health problem worldwide characterized by intrahepatic triacylglycerol ( TG ) overaccumulation .',
  'Fatty liver disease ( FLD ) , associated with chronic alcohol consumption or obesity , is a serious medical problem .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious health problem affecting ~25 % of the global population .',
  'Nonalcoholic steatohepatitis ( NASH ) is a serious and rapidly growing problem affecting a population that was not previously recognized as high risk .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is now the most frequent chronic liver disease that occurs across all age groups and is recognized to occur in 14%-30 % of the general population , representing a serious and growing clinical problem due to the growing prevalence of obesity and overweight .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious public health concern that affects almost one third of the US population .',
  'Non-alcoholic steatohepatitis ( NASH ) is the most severe form of non-alcoholic fatty liver disease and is a serious public health problem around the world .',
  'Fatty liver disease associated with chronic alcohol consumption or obesity/type 2 diabetes has emerged as a serious public health problem .',
  'Non-alcoholic fatty liver disease is a serious health problem linked to obesity and type 2 diabetes .',
  'To date , no approved drugs are available for the treatment of NAFLD , despite the fact that it represents a serious and growing clinical problem in the Western world .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious health concern in China .',
  'Fatty liver disease is a serious health problem worldwide and is the most common cause for chronic liver disease and metabolic disorders .',
  'The non-alcoholic fatty liver disease ( NAFLD ) has become a serious medical problem and an increasing threat to public health .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious public health problem .',
  'Non-alcoholic fatty liver disease is a serious and growing clinical problem .',
  'Currently , fatty liver represents a serious public health problem in the Western world .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is a serious global public health concern .',
  'Non-alcoholic fatty liver disease ( NAFLD ) is one of the most frequent causes of liver disease and its prevalence is a serious and growing clinical problem .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious health problem in developed countries .',
  'Non-alcoholic steatohepatitis ( NASH ) has become a serious public health problem associated with metabolic syndrome .',
  'Alcoholic and non-alcoholic fatty liver diseases have become a serious concern whole over the world .',
  'Nonalcoholic fatty liver disease ( NAFLD ) is a serious health problem .',
  'The progression in nonalcoholic fatty liver disease ( NAFLD ) to nonalcoholic steatohepatitis is a serious health concern , but the underlying mechanisms remain unclear .'],
 'metabolic': ['Metabolic syndrome is a subclinical status in promoting atherosclerotic cardiovascular disease and type 2 diabetes mellitus',
  'Although a universally accepted definition is still lacking because available classifications present slightly different diagnostic criteria , the metabolic syndrome is now recognized as a serious public health problem that affects up to 45 % of the population > 50 years of age in the United States and approximately 20 to 25 % of the adult population in Europe .',
  'The current prevalence of metabolic syndrome in women in rural communities of the selected area , although less than that in their urban counterparts , could be a serious problem in the future .',
  'The high prevalence of the metabolic syndrome is a serious public health problem in Hungary , and remains a major determinant of the high burden of cardiovascular disease .',
  'Metabolic syndrome ( MS ) is becoming a serious global public health problem .',
  'Metabolic syndrome ( MetS ) which is caused by poor dietary habits and sedentary behavior is a serious global health problem .',
  'The increasing number of people suffering from metabolic syndrome and obesity is becoming a serious problem not only in developed countries , but also in developing countries .',
  'PRACTICAL APPLICATIONS : Metabolic syndrome is a serious health problem .',
  'The persistent increase of MetSyn among U.S. adults is a serious public health concern because it raises the likelihood of increased prevalence of type 2 diabetes .',
  'The metabolic syndrome ( MetS ) is defined as a cluster of 3 or more metabolic and cardiovascular risk factors and represents a serious problem for public health .',
  'High prevalence of MetS especially among overweight and obese adolescents is a serious health problem .',
  'Metabolic syndrome ( MS ) is emerging as a serious public health problem in Korea .',
  'Metabolic syndrome ( MetS ) is a serious public health problem .',
  'Metabolic syndrome ( MetS ) is a serious public health problem and one of the important risk factors contributing to cardiovascular disease in developed countries .',
  'Metabolic syndrome is a serious health problem and is associated with an increased risk of type 2 diabetes and cardiovascular disease .',
  'The increasing prevalence of metabolic abnormalities worldwide presents a serious public health problem , with rates of obesity and diabetes reaching unprecedented levels .',
  'Metabolic syndrome is a cluster of pathologies and conditions such as obesity , hyperglycemia , hyperlipidemia and hypertension representing a serious health concern in many countries due to its high rate of mortality and morbidity .',
  'Metabolic syndrome ( MetS ) is a serious public health concern worldwide ; however , the pathogenesis of this disease has not been yet cleared .',
  'Several studies have described the association between metabolic syndrome and ischaemic heart disease , however , none linked metabolic syndrome to ischemic mitral regurgitation , a serious clinical problem facing both the cardiologists and cardiac surgeons .',
  'The growing prevalence of metabolic syndrome ( MetS ) in the U.S. and even worldwide is becoming a serious health problem and economic burden .',
  'These metabolic syndromes have become a serious problem in developed countries , and there is an increased need for research examining the influence of carbohydrates on animal physiology .',
  'Hyperglycemia and dyslipidemia are characteristic features of the metabolic syndrome , a serious public health problem with rising prevalence .',
  'MetS is a serious health problem because of its related cardiovascular complications , which include hypertension and delayed heart rate recovery after exercise .',
  'Metabolic syndrome is a serious health problem in the present world .',
  'Metabolic syndrome is a serious health problem in both developed and developing countries .',
  'Background Metabolic syndrome ( MetS ) is a serious health problem over the world ; thus , the aim of the present work was to develop a lifestyle intervention to decrease the dysbiosis of gut microbiota and reduce the biochemical abnormalities of MetS. Methods and Results The prevalence of MetS was evaluated in 1065 subjects of Mexico City , Mexico , and the gut microbiota in a subsample .',
  'A high calorie intake can induce the appearance of the metabolic syndrome ( MS ) , which is a serious public health problem because it affects glucose levels and triglycerides in the blood .',
  'OBJECTIVE Metabolic syndrome ( MetS ) is becoming a serious public health concern in many countries , including South Korea , which has faced remarkable changes in lifestyles and disease patterns in recent decades .',
  'A sedentary lifestyle combined with the intake of high-calorie diet has been the paramount cause of metabolic syndrome ( MS ) which is now a serious concern of public health worldwide as it involves the coexistence of hypertension , hyperlipidemia , glucose intolerance , and obesity .',
  'Metabolic syndrome ( MS ) is a serious public health problem , which can promote neuronal alterations in cognitive regions related to learning and memory processes , such as the hippocampus .',
  'An Indiana study : an original clinical approach to a fatal metabolic problem .',
  'Metabolic syndrome ( MetS ) becomes a serious society health problem .',
  'MetS has become a serious public health and clinical problem whose prevalence and incidence are increasing along with the worldwide rise in rates of obesity and sedentary lifestyles .',
  'The prevalence of obesity is on the increase , and consequently metabolic syndrome is also becoming a serious health problem in children and adolescents all over the world .',
  'Metabolic syndrome not only is a serious problem for adults , but is also afflicting an increasing number of children and adolescents .'],
 'cartilage': ['Osteoarthritis (OA)-the progressive degeneration of synovial joints-is a\xa0worldwide problem that affects society, is associated with age and is the dominant reason for pain and immobility of the locomotor system',
  'Osteoarthritis (OA) is an orthopedic inflammatory disease which can cause functional disability and chronic pain',
  'Recent evidence indicates that a major drawback of current cartilage- and disc-tissue engineering is that human mesenchymal stem cells ( MSCs ) rapidly express type X collagen-a marker of chondrocyte hypertrophy associated with endochondral ossification .',
  'We conclude that posterolateral lumbosacral fusion with transpedicular fixation provides a satisfactory clinical outcome in patients with spondylolysis-olisthesis , but the high incidence of complications related to the fixation device in the other indications studied is a serious drawback of the method .',
  'However , recent evidence indicates that a major drawback of current cartilage- and intervertebral disc-tissue engineering is that human MSCs isolated from some arthritic patients ( a clinically relevant source of stem cells ) express type X collagen ( a marker of chondrocyte hypertrophy associated with endochondral ossification ) and osteogenic markers .',
  'Recent evidence indicates that a major drawback of current cartilage- and intervertebral disc ( IVD ) tissue engineering is that human mesenchymal stem cells ( MSCs ) from patients with osteoarthritis rapidly express type X collagen ( COL10A1 ) , a marker of late stage chondrocyte hypertrophy associated with endochondral ossification .',
  'A major drawback of current cartilage and intervertebral disc tissue engineering is that human mesenchymal stem cells ( MSCs ) from osteoarthritic ( OA ) patients express type X collagen ( COL10 ) , a marker of late-stage chondrocyte hypertrophy ( associated with endochondral ossification ) .',
  'Previous studies have shown that a major drawback of current cartilage and intervertebral disc tissue repair is that human MSCs from OA patients express type X collagen ( COL X ) .',
  'Chronic disruption of the extensor mechanism is a devastating problem after total knee arthroplasty .',
  'Degradation of mechanical properties of cartilage is a serious , still not fully clarified problem that deserves attention .',
  'Knee arthrosis is a serious health problem , given the significant rate of disability among patients and the significant reduction in the quality of life .',
  'Articular cartilage damage is still a troublesome problem .',
  'Joint pain due to cartilage degeneration is a serious problem , affecting people of all ages .',
  'Chondrocyte biology is a hot topic , because osteoarthritis ( OA ) is a serious problem in an aging society , but there are no fundamental therapeutic drugs [ ... ] .',
  'Osteoarthritis ( OA ) is a serious sociomedical problem , one of the leading causes of persistent disability and reduced quality of life .',
  'Osteoarthritis ( OA ) is a serious health concern globally and is recognized by degradation of articular cartilage , bone remodeling and synovial inflammation .',
  'Pyogenic arthritis of the hip in neonates remains a serious problem .',
  'Osteoarthritis ( OA ) as a debilitating affliction of joints currently affects millions of people and remains an unsolved problem .',
  'Articular cartilage injury and degeneration causing pain and loss of quality-of-life has become a serious problem for increasingly aged populations .',
  'Soft tissue defects after knee arthroplasty are a severe problem , which can even result in a loss of the prosthesis or the limb .',
  'Osteoarthritis ( OA ) is a serious public health problem that affects millions in the United States ( Hootman & Helmick , 2006 ) .',
  'Pyogenic knee arthritis in a patient with advanced osteoarthritis is a serious medical problem .',
  'Osteoarthritis ( OA ) is a serious problem in the recent aging society , and early diagnosis and intervention of articular cartilage degeneration are very important for the onset of OA .',
  'Appearance of surface fissures in articular cartilage is a serious , still not fully clarified problem that deserves attention .',
  'Osteoarthritis is a serious social problem .',
  'Rheumatoid arthritis of the foot and ankle can be a debilitating problem , particularly for patients who have undergone successful hip or knee arthroplasty .',
  'Because articular cartilage is avascular and has no intrinsic capacity to heal itself , physical damage to cartilage poses a serious clinical problem for orthopedic surgeons and rheumatologists .',
  'Pain in the joint is often due to cartilage degeneration and represents a serious medical problem affecting people of all ages .',
  'PURPOSE OF THE STUDY Damage to hyaline cartilage represents a serious problem due to its limited capacity of regeneration .',
  'As populations age , we can expect knee OA to become a serious public health problem .',
  'Degeneration of articular cartilage in osteoarthritis is a serious medical problem .',
  'Osteoarthritis is a debilitating condition as well as a growing global health problem , and total knee arthroplasty is an effective treatment for advanced stages of disease .',
  'The progressive degeneration of articular cartilage or osteoarthritis of the knee is a serious clinical problem affecting patient quality of life .',
  'Disturbance of growth and bone metabolism is a serious problem in juvenile chronic arthritis .',
  'Spondylodiscitis is a serious and important clinical problem that can occur after iatrogenic interventions and should be kept in mind .',
  'Such gross knee contractures together with the coexisting hip flexion contractures create a severe nursing problem .',
  'Osteoarthritis is a serious and prevalent health problem that creates considerable disability when it involves the knee or hip joints .',
  'Chronic instability of the knee joint is a serious problem for the affected patient and the attending physician .',
  'A serious problem in juvenile idiopathic arthritis is skeletal growth retardation , osteopenia and greater risk of developing fractures .',
  "This paper contributes to the identification of risk factors for KOA progression via a robust feature selection ( FS ) methodology that overcomes two crucial challenges : ( i ) the observed high dimensionality and heterogeneity of the available data that are obtained from the Osteoarthritis Initiative ( OAI ) database and ( ii ) a severe class imbalance problem posed by the fact that the KOA progressors class is significantly smaller than the non-progressors ' class .",
  'Osteoarthritis is a debilitating condition as well as a growing global health problem , and total knee arthroplasty ( TKA ) is an effective treatment for advanced disease .',
  'Cartilage defects represent a serious problem due to the poor regenerative properties of this tissue .',
  'Spondyloarthtritis ( SpA ) present a serious health , social and economical problem everywhere in the world .',
  'Osteoarthritis is a serious medical , social and economic problem affecting populations worldwide .'],
 'osteoarthritis': ['Osteoarthritis (OA)-the progressive degeneration of synovial joints-is a\xa0worldwide problem that affects society, is associated with age and is the dominant reason for pain and immobility of the locomotor system',
  'Osteoarthritis (OA) is an orthopedic inflammatory disease which can cause functional disability and chronic pain',
  'Recent evidence indicates that a major drawback of current cartilage- and disc-tissue engineering is that human mesenchymal stem cells ( MSCs ) rapidly express type X collagen-a marker of chondrocyte hypertrophy associated with endochondral ossification .',
  'We conclude that posterolateral lumbosacral fusion with transpedicular fixation provides a satisfactory clinical outcome in patients with spondylolysis-olisthesis , but the high incidence of complications related to the fixation device in the other indications studied is a serious drawback of the method .',
  'However , recent evidence indicates that a major drawback of current cartilage- and intervertebral disc-tissue engineering is that human MSCs isolated from some arthritic patients ( a clinically relevant source of stem cells ) express type X collagen ( a marker of chondrocyte hypertrophy associated with endochondral ossification ) and osteogenic markers .',
  'Recent evidence indicates that a major drawback of current cartilage- and intervertebral disc ( IVD ) tissue engineering is that human mesenchymal stem cells ( MSCs ) from patients with osteoarthritis rapidly express type X collagen ( COL10A1 ) , a marker of late stage chondrocyte hypertrophy associated with endochondral ossification .',
  'A major drawback of current cartilage and intervertebral disc tissue engineering is that human mesenchymal stem cells ( MSCs ) from osteoarthritic ( OA ) patients express type X collagen ( COL10 ) , a marker of late-stage chondrocyte hypertrophy ( associated with endochondral ossification ) .',
  'Previous studies have shown that a major drawback of current cartilage and intervertebral disc tissue repair is that human MSCs from OA patients express type X collagen ( COL X ) .',
  'Chronic disruption of the extensor mechanism is a devastating problem after total knee arthroplasty .',
  'Degradation of mechanical properties of cartilage is a serious , still not fully clarified problem that deserves attention .',
  'Knee arthrosis is a serious health problem , given the significant rate of disability among patients and the significant reduction in the quality of life .',
  'Articular cartilage damage is still a troublesome problem .',
  'Joint pain due to cartilage degeneration is a serious problem , affecting people of all ages .',
  'Chondrocyte biology is a hot topic , because osteoarthritis ( OA ) is a serious problem in an aging society , but there are no fundamental therapeutic drugs [ ... ] .',
  'Osteoarthritis ( OA ) is a serious sociomedical problem , one of the leading causes of persistent disability and reduced quality of life .',
  'Osteoarthritis ( OA ) is a serious health concern globally and is recognized by degradation of articular cartilage , bone remodeling and synovial inflammation .',
  'Pyogenic arthritis of the hip in neonates remains a serious problem .',
  'Osteoarthritis ( OA ) as a debilitating affliction of joints currently affects millions of people and remains an unsolved problem .',
  'Articular cartilage injury and degeneration causing pain and loss of quality-of-life has become a serious problem for increasingly aged populations .',
  'Soft tissue defects after knee arthroplasty are a severe problem , which can even result in a loss of the prosthesis or the limb .',
  'Osteoarthritis ( OA ) is a serious public health problem that affects millions in the United States ( Hootman & Helmick , 2006 ) .',
  'Pyogenic knee arthritis in a patient with advanced osteoarthritis is a serious medical problem .',
  'Osteoarthritis ( OA ) is a serious problem in the recent aging society , and early diagnosis and intervention of articular cartilage degeneration are very important for the onset of OA .',
  'Appearance of surface fissures in articular cartilage is a serious , still not fully clarified problem that deserves attention .',
  'Osteoarthritis is a serious social problem .',
  'Rheumatoid arthritis of the foot and ankle can be a debilitating problem , particularly for patients who have undergone successful hip or knee arthroplasty .',
  'Because articular cartilage is avascular and has no intrinsic capacity to heal itself , physical damage to cartilage poses a serious clinical problem for orthopedic surgeons and rheumatologists .',
  'Pain in the joint is often due to cartilage degeneration and represents a serious medical problem affecting people of all ages .',
  'PURPOSE OF THE STUDY Damage to hyaline cartilage represents a serious problem due to its limited capacity of regeneration .',
  'As populations age , we can expect knee OA to become a serious public health problem .',
  'Degeneration of articular cartilage in osteoarthritis is a serious medical problem .',
  'Osteoarthritis is a debilitating condition as well as a growing global health problem , and total knee arthroplasty is an effective treatment for advanced stages of disease .',
  'The progressive degeneration of articular cartilage or osteoarthritis of the knee is a serious clinical problem affecting patient quality of life .',
  'Disturbance of growth and bone metabolism is a serious problem in juvenile chronic arthritis .',
  'Spondylodiscitis is a serious and important clinical problem that can occur after iatrogenic interventions and should be kept in mind .',
  'Such gross knee contractures together with the coexisting hip flexion contractures create a severe nursing problem .',
  'Osteoarthritis is a serious and prevalent health problem that creates considerable disability when it involves the knee or hip joints .',
  'Chronic instability of the knee joint is a serious problem for the affected patient and the attending physician .',
  'A serious problem in juvenile idiopathic arthritis is skeletal growth retardation , osteopenia and greater risk of developing fractures .',
  "This paper contributes to the identification of risk factors for KOA progression via a robust feature selection ( FS ) methodology that overcomes two crucial challenges : ( i ) the observed high dimensionality and heterogeneity of the available data that are obtained from the Osteoarthritis Initiative ( OAI ) database and ( ii ) a severe class imbalance problem posed by the fact that the KOA progressors class is significantly smaller than the non-progressors ' class .",
  'Osteoarthritis is a debilitating condition as well as a growing global health problem , and total knee arthroplasty ( TKA ) is an effective treatment for advanced disease .',
  'Cartilage defects represent a serious problem due to the poor regenerative properties of this tissue .',
  'Spondyloarthtritis ( SpA ) present a serious health , social and economical problem everywhere in the world .',
  'Osteoarthritis is a serious medical , social and economic problem affecting populations worldwide .'],
 'knee': ['Osteoarthritis (OA)-the progressive degeneration of synovial joints-is a\xa0worldwide problem that affects society, is associated with age and is the dominant reason for pain and immobility of the locomotor system',
  'Osteoarthritis (OA) is an orthopedic inflammatory disease which can cause functional disability and chronic pain',
  'The problem with calling it by this name is that it surrounds a true mixed peripheral nerve and not a radicule ( root ) .',
  'Recent evidence indicates that a major drawback of current cartilage- and disc-tissue engineering is that human mesenchymal stem cells ( MSCs ) rapidly express type X collagen-a marker of chondrocyte hypertrophy associated with endochondral ossification .',
  'We conclude that posterolateral lumbosacral fusion with transpedicular fixation provides a satisfactory clinical outcome in patients with spondylolysis-olisthesis , but the high incidence of complications related to the fixation device in the other indications studied is a serious drawback of the method .',
  'However , recent evidence indicates that a major drawback of current cartilage- and intervertebral disc-tissue engineering is that human MSCs isolated from some arthritic patients ( a clinically relevant source of stem cells ) express type X collagen ( a marker of chondrocyte hypertrophy associated with endochondral ossification ) and osteogenic markers .',
  'Recent evidence indicates that a major drawback of current cartilage- and intervertebral disc ( IVD ) tissue engineering is that human mesenchymal stem cells ( MSCs ) from patients with osteoarthritis rapidly express type X collagen ( COL10A1 ) , a marker of late stage chondrocyte hypertrophy associated with endochondral ossification .',
  'A major drawback of current cartilage and intervertebral disc tissue engineering is that human mesenchymal stem cells ( MSCs ) from osteoarthritic ( OA ) patients express type X collagen ( COL10 ) , a marker of late-stage chondrocyte hypertrophy ( associated with endochondral ossification ) .',
  'Previous studies have shown that a major drawback of current cartilage and intervertebral disc tissue repair is that human MSCs from OA patients express type X collagen ( COL X ) .',
  'Chronic disruption of the extensor mechanism is a devastating problem after total knee arthroplasty .',
  'Common peroneal nerve ( CPN ) injury following a knee dislocation is a serious problem , and an optimal treatment is yet to be established .',
  'Degradation of mechanical properties of cartilage is a serious , still not fully clarified problem that deserves attention .',
  'Peripheral nerve regeneration is a serious clinical problem .',
  'Knee arthrosis is a serious health problem , given the significant rate of disability among patients and the significant reduction in the quality of life .',
  'Articular cartilage damage is still a troublesome problem .',
  'Joint pain due to cartilage degeneration is a serious problem , affecting people of all ages .',
  'Neuromas are a debilitating peripheral nerve problem due to aberrant axon sprouting and inflammation after nerve injury .',
  'Chondrocyte biology is a hot topic , because osteoarthritis ( OA ) is a serious problem in an aging society , but there are no fundamental therapeutic drugs [ ... ] .',
  'Peripheral nerve involvement has been described at alarming rates in some studies , which increases the chance of deformities , a serious problem , especially if one considers the age of these patients .',
  'Osteoarthritis ( OA ) is a serious sociomedical problem , one of the leading causes of persistent disability and reduced quality of life .',
  'Nerve injury , especially the large-size nerve damage , is a serious problem affecting millions of people .',
  'Osteoarthritis ( OA ) is a serious health concern globally and is recognized by degradation of articular cartilage , bone remodeling and synovial inflammation .',
  'Perioperative peripheral neuropathy in abdominal free flap breast reconstruction is a preventable problem .',
  'Pyogenic arthritis of the hip in neonates remains a serious problem .',
  'Peripheral nerves are exposed to physical injuries usually caused by trauma that may lead to a significant loss of sensory or motor functions and is considered as a serious health problem for societies today .',
  'Osteoarthritis ( OA ) as a debilitating affliction of joints currently affects millions of people and remains an unsolved problem .',
  'Articular cartilage injury and degeneration causing pain and loss of quality-of-life has become a serious problem for increasingly aged populations .',
  'Poor muscle and nerve functional recovery after nerve damage is a serious clinical problem , particularly if there is prolonged delay before nerve-muscle contact is reestablished .',
  'Soft tissue defects after knee arthroplasty are a severe problem , which can even result in a loss of the prosthesis or the limb .',
  'Osteoarthritis ( OA ) is a serious public health problem that affects millions in the United States ( Hootman & Helmick , 2006 ) .',
  'Peripheral nerve injury is a serious clinical problem to be solved .',
  'Pyogenic knee arthritis in a patient with advanced osteoarthritis is a serious medical problem .',
  'Osteoarthritis ( OA ) is a serious problem in the recent aging society , and early diagnosis and intervention of articular cartilage degeneration are very important for the onset of OA .',
  'Peripheral nerve injury ( PNI ) is a serious clinical health problem caused by the damage of peripheral nerves which results in neurological deficits and permanent disability .',
  'Peripheral nerve injury is a serious medical problem and severely affects normal life of patient .',
  'Appearance of surface fissures in articular cartilage is a serious , still not fully clarified problem that deserves attention .',
  'Osteoarthritis is a serious social problem .',
  'Rheumatoid arthritis of the foot and ankle can be a debilitating problem , particularly for patients who have undergone successful hip or knee arthroplasty .',
  'Because articular cartilage is avascular and has no intrinsic capacity to heal itself , physical damage to cartilage poses a serious clinical problem for orthopedic surgeons and rheumatologists .',
  'Pain in the joint is often due to cartilage degeneration and represents a serious medical problem affecting people of all ages .',
  'Peroneal nerve palsy after knee dislocation is a serious problem , and neurolysis at the time of knee reconstruction does not always result in return of peroneal nerve function .',
  'PURPOSE OF THE STUDY Damage to hyaline cartilage represents a serious problem due to its limited capacity of regeneration .',
  'As populations age , we can expect knee OA to become a serious public health problem .',
  'Degeneration of articular cartilage in osteoarthritis is a serious medical problem .',
  'Knee dislocation with a common peroneal nerve injury is a serious problem .',
  "Peripheral nerve injury is a serious problem affecting significantly patients ' life .",
  'Osteoarthritis is a debilitating condition as well as a growing global health problem , and total knee arthroplasty is an effective treatment for advanced stages of disease .',
  'The progressive degeneration of articular cartilage or osteoarthritis of the knee is a serious clinical problem affecting patient quality of life .',
  'Disturbance of growth and bone metabolism is a serious problem in juvenile chronic arthritis .',
  'Spondylodiscitis is a serious and important clinical problem that can occur after iatrogenic interventions and should be kept in mind .',
  'Such gross knee contractures together with the coexisting hip flexion contractures create a severe nursing problem .',
  'Osteoarthritis is a serious and prevalent health problem that creates considerable disability when it involves the knee or hip joints .',
  'Chronic instability of the knee joint is a serious problem for the affected patient and the attending physician .',
  'A serious problem in juvenile idiopathic arthritis is skeletal growth retardation , osteopenia and greater risk of developing fractures .',
  'Peroneal nerve palsy following knee dislocation is a serious problem , and neurolysis at the time of knee reconstruction does not always result in return of peroneal nerve function .',
  "This paper contributes to the identification of risk factors for KOA progression via a robust feature selection ( FS ) methodology that overcomes two crucial challenges : ( i ) the observed high dimensionality and heterogeneity of the available data that are obtained from the Osteoarthritis Initiative ( OAI ) database and ( ii ) a severe class imbalance problem posed by the fact that the KOA progressors class is significantly smaller than the non-progressors ' class .",
  'Osteoarthritis is a debilitating condition as well as a growing global health problem , and total knee arthroplasty ( TKA ) is an effective treatment for advanced disease .',
  'Cartilage defects represent a serious problem due to the poor regenerative properties of this tissue .',
  'Spondyloarthtritis ( SpA ) present a serious health , social and economical problem everywhere in the world .',
  'Osteoarthritis is a serious medical , social and economic problem affecting populations worldwide .',
  'Peripheral nerve injury ( PNI ) is a serious public health problem that is linked with motor , sensory and autonomic deficits .'],
 'articular': ['Osteoarthritis (OA)-the progressive degeneration of synovial joints-is a\xa0worldwide problem that affects society, is associated with age and is the dominant reason for pain and immobility of the locomotor system',
  'Osteoarthritis (OA) is an orthopedic inflammatory disease which can cause functional disability and chronic pain',
  'Recent evidence indicates that a major drawback of current cartilage- and disc-tissue engineering is that human mesenchymal stem cells ( MSCs ) rapidly express type X collagen-a marker of chondrocyte hypertrophy associated with endochondral ossification .',
  'We conclude that posterolateral lumbosacral fusion with transpedicular fixation provides a satisfactory clinical outcome in patients with spondylolysis-olisthesis , but the high incidence of complications related to the fixation device in the other indications studied is a serious drawback of the method .',
  'However , recent evidence indicates that a major drawback of current cartilage- and intervertebral disc-tissue engineering is that human MSCs isolated from some arthritic patients ( a clinically relevant source of stem cells ) express type X collagen ( a marker of chondrocyte hypertrophy associated with endochondral ossification ) and osteogenic markers .',
  'Recent evidence indicates that a major drawback of current cartilage- and intervertebral disc ( IVD ) tissue engineering is that human mesenchymal stem cells ( MSCs ) from patients with osteoarthritis rapidly express type X collagen ( COL10A1 ) , a marker of late stage chondrocyte hypertrophy associated with endochondral ossification .',
  'A major drawback of current cartilage and intervertebral disc tissue engineering is that human mesenchymal stem cells ( MSCs ) from osteoarthritic ( OA ) patients express type X collagen ( COL10 ) , a marker of late-stage chondrocyte hypertrophy ( associated with endochondral ossification ) .',
  'Previous studies have shown that a major drawback of current cartilage and intervertebral disc tissue repair is that human MSCs from OA patients express type X collagen ( COL X ) .',
  'Chronic disruption of the extensor mechanism is a devastating problem after total knee arthroplasty .',
  'Degradation of mechanical properties of cartilage is a serious , still not fully clarified problem that deserves attention .',
  'Knee arthrosis is a serious health problem , given the significant rate of disability among patients and the significant reduction in the quality of life .',
  'Articular cartilage damage is still a troublesome problem .',
  'Joint pain due to cartilage degeneration is a serious problem , affecting people of all ages .',
  'Chondrocyte biology is a hot topic , because osteoarthritis ( OA ) is a serious problem in an aging society , but there are no fundamental therapeutic drugs [ ... ] .',
  'Osteoarthritis ( OA ) is a serious sociomedical problem , one of the leading causes of persistent disability and reduced quality of life .',
  'Osteoarthritis ( OA ) is a serious health concern globally and is recognized by degradation of articular cartilage , bone remodeling and synovial inflammation .',
  'Pyogenic arthritis of the hip in neonates remains a serious problem .',
  'Osteoarthritis ( OA ) as a debilitating affliction of joints currently affects millions of people and remains an unsolved problem .',
  'Articular cartilage injury and degeneration causing pain and loss of quality-of-life has become a serious problem for increasingly aged populations .',
  'Soft tissue defects after knee arthroplasty are a severe problem , which can even result in a loss of the prosthesis or the limb .',
  'Osteoarthritis ( OA ) is a serious public health problem that affects millions in the United States ( Hootman & Helmick , 2006 ) .',
  'Pyogenic knee arthritis in a patient with advanced osteoarthritis is a serious medical problem .',
  'Osteoarthritis ( OA ) is a serious problem in the recent aging society , and early diagnosis and intervention of articular cartilage degeneration are very important for the onset of OA .',
  'Appearance of surface fissures in articular cartilage is a serious , still not fully clarified problem that deserves attention .',
  'Osteoarthritis is a serious social problem .',
  'Rheumatoid arthritis of the foot and ankle can be a debilitating problem , particularly for patients who have undergone successful hip or knee arthroplasty .',
  'Because articular cartilage is avascular and has no intrinsic capacity to heal itself , physical damage to cartilage poses a serious clinical problem for orthopedic surgeons and rheumatologists .',
  'Pain in the joint is often due to cartilage degeneration and represents a serious medical problem affecting people of all ages .',
  'PURPOSE OF THE STUDY Damage to hyaline cartilage represents a serious problem due to its limited capacity of regeneration .',
  'As populations age , we can expect knee OA to become a serious public health problem .',
  'Degeneration of articular cartilage in osteoarthritis is a serious medical problem .',
  'Osteoarthritis is a debilitating condition as well as a growing global health problem , and total knee arthroplasty is an effective treatment for advanced stages of disease .',
  'The progressive degeneration of articular cartilage or osteoarthritis of the knee is a serious clinical problem affecting patient quality of life .',
  'Disturbance of growth and bone metabolism is a serious problem in juvenile chronic arthritis .',
  'Spondylodiscitis is a serious and important clinical problem that can occur after iatrogenic interventions and should be kept in mind .',
  'Such gross knee contractures together with the coexisting hip flexion contractures create a severe nursing problem .',
  'Osteoarthritis is a serious and prevalent health problem that creates considerable disability when it involves the knee or hip joints .',
  'Chronic instability of the knee joint is a serious problem for the affected patient and the attending physician .',
  'A serious problem in juvenile idiopathic arthritis is skeletal growth retardation , osteopenia and greater risk of developing fractures .',
  "This paper contributes to the identification of risk factors for KOA progression via a robust feature selection ( FS ) methodology that overcomes two crucial challenges : ( i ) the observed high dimensionality and heterogeneity of the available data that are obtained from the Osteoarthritis Initiative ( OAI ) database and ( ii ) a severe class imbalance problem posed by the fact that the KOA progressors class is significantly smaller than the non-progressors ' class .",
  'Osteoarthritis is a debilitating condition as well as a growing global health problem , and total knee arthroplasty ( TKA ) is an effective treatment for advanced disease .',
  'Cartilage defects represent a serious problem due to the poor regenerative properties of this tissue .',
  'Spondyloarthtritis ( SpA ) present a serious health , social and economical problem everywhere in the world .',
  'Osteoarthritis is a serious medical , social and economic problem affecting populations worldwide .'],
 'ovarian': ['According to modern statistics, endometriosis is a disease that occupies the third place among the most problematic diseases of the female reproductive system, since it develops mainly in young women and, therefore, negatively affects their reproductive function',
  'Endometriosis ( EM ) is morphologically characterized by the development of extrauterine endometrioid heterotopies , the major clinical symptoms of which is chronic pelvic pain , which is a serious problem not only in modern gynecology , but also in public health as a whole .',
  'Adenomyosis of the uterus is a serious problem for women of reproductive age because of its possible consequence of infertility .',
  'Gynecological cancers constitute a serious problem in the world .',
  'Ovary cancer is a disease charged of paradigms and a serious health problem .',
  'Ovarian cancer ( OC ) is a serious public health concern in the world .',
  'Endometriosis is a serious clinical problem among the women treated because of gynecological reasons .',
  'It is also a serious problem for endometrial cancer ( EC ) study .',
  'Background Severe forms of adenomyosis are a serious gynecological problem .',
  'Metastatic lesions within the ovary constitute a serious diagnostic problem in daily practice .',
  'Risk assessment for epithelial ovarian cancer : proposing a new approach to a deadly problem .',
  'Adenomyomectomy is conservative surgery that is now widely applied ; however , relapse is a serious problem after the operation .',
  'Nevertheless , since development of ovarian carcinoma in infertile women during infertility treatment is a serious concern for gynecologists , this review also covers important points for clinical practice , especially the issue of early detection of ovarian carcinoma .',
  'Ovarian tumor in pregnancy is a distressing problem for the obstetrician .',
  'The massive ovarian cyst ( greater than 25 pounds ) presents a challenging opportunity for surgical intervention and potential cure of a debilitating problem .',
  'Despite advances in cytotoxic chemotherapy and surgical cytoreduction , disease recurrence continues to be a troubling problem in patients with advanced-stage epithelial ovarian cancer ( EOC ) .',
  'Uterine leiomyomas ( LMs ) , currently the most common gynecological complaint around the world , are a serious medical , social and economic problem .',
  'Epithelial ovarian cancer is a serious public health problem worldwide with the highest mortality rate of all gynecologic cancers .',
  'While surgery is currently the treatment of choice for endometriosis , recurrence remains a serious problem , and its prevention is an unmet clinical need .',
  'The presence of a suspicious ovarian cyst with elevated cancer antigen 125 level in a woman of reproductive age poses a serious therapeutic dilemma .',
  'Ovarian cancer is a life-threatening diagnosis which poses multiple challenges .',
  'Ovarian cancer is a disease laden with paradigms , and it is a serious health problem .',
  'Resistance to chemotherapy poses a serious problem for the treatment of advanced epithelial ovarian cancer patients .',
  'Premature ovarian failure during chemotherapy is a serious problem for young women with cancer .',
  'Malignant tumors of the female reproductive system are a serious health and social problem , as they are the second most common cause of death among women , after breast cancer .',
  'Malignant tumors of the female reproductive system are a serious health and social problem , as they are the second most common cause of death among women , after breast cancer .',
  'Any cancer in pregnancy is a catastrophic event for the woman and her partner , and poses great challenges for the multidisciplinary team responsible for her care .',
  'Endometrial cancer remains , today , a serious problem , especially for postmenopausal women .',
  'Spinal tumors are rare in pregnancy , but they cause a serious problem in terms of continuing pregnancy .'],
 'endometriosis': ['According to modern statistics, endometriosis is a disease that occupies the third place among the most problematic diseases of the female reproductive system, since it develops mainly in young women and, therefore, negatively affects their reproductive function',
  'Endometriosis ( EM ) is morphologically characterized by the development of extrauterine endometrioid heterotopies , the major clinical symptoms of which is chronic pelvic pain , which is a serious problem not only in modern gynecology , but also in public health as a whole .',
  'Adenomyosis of the uterus is a serious problem for women of reproductive age because of its possible consequence of infertility .',
  'Gynecological cancers constitute a serious problem in the world .',
  'Ovary cancer is a disease charged of paradigms and a serious health problem .',
  'Ovarian cancer ( OC ) is a serious public health concern in the world .',
  'Endometriosis is a serious clinical problem among the women treated because of gynecological reasons .',
  'It is also a serious problem for endometrial cancer ( EC ) study .',
  'Background Severe forms of adenomyosis are a serious gynecological problem .',
  'Metastatic lesions within the ovary constitute a serious diagnostic problem in daily practice .',
  'Risk assessment for epithelial ovarian cancer : proposing a new approach to a deadly problem .',
  'Adenomyomectomy is conservative surgery that is now widely applied ; however , relapse is a serious problem after the operation .',
  'Nevertheless , since development of ovarian carcinoma in infertile women during infertility treatment is a serious concern for gynecologists , this review also covers important points for clinical practice , especially the issue of early detection of ovarian carcinoma .',
  'Ovarian tumor in pregnancy is a distressing problem for the obstetrician .',
  'The massive ovarian cyst ( greater than 25 pounds ) presents a challenging opportunity for surgical intervention and potential cure of a debilitating problem .',
  'Despite advances in cytotoxic chemotherapy and surgical cytoreduction , disease recurrence continues to be a troubling problem in patients with advanced-stage epithelial ovarian cancer ( EOC ) .',
  'Uterine leiomyomas ( LMs ) , currently the most common gynecological complaint around the world , are a serious medical , social and economic problem .',
  'Epithelial ovarian cancer is a serious public health problem worldwide with the highest mortality rate of all gynecologic cancers .',
  'While surgery is currently the treatment of choice for endometriosis , recurrence remains a serious problem , and its prevention is an unmet clinical need .',
  'The presence of a suspicious ovarian cyst with elevated cancer antigen 125 level in a woman of reproductive age poses a serious therapeutic dilemma .',
  'Ovarian cancer is a life-threatening diagnosis which poses multiple challenges .',
  'Ovarian cancer is a disease laden with paradigms , and it is a serious health problem .',
  'Resistance to chemotherapy poses a serious problem for the treatment of advanced epithelial ovarian cancer patients .',
  'Premature ovarian failure during chemotherapy is a serious problem for young women with cancer .',
  'Malignant tumors of the female reproductive system are a serious health and social problem , as they are the second most common cause of death among women , after breast cancer .',
  'Malignant tumors of the female reproductive system are a serious health and social problem , as they are the second most common cause of death among women , after breast cancer .',
  'Any cancer in pregnancy is a catastrophic event for the woman and her partner , and poses great challenges for the multidisciplinary team responsible for her care .',
  'Endometrial cancer remains , today , a serious problem , especially for postmenopausal women .',
  'Spinal tumors are rare in pregnancy , but they cause a serious problem in terms of continuing pregnancy .'],
 'gynecological': ['According to modern statistics, endometriosis is a disease that occupies the third place among the most problematic diseases of the female reproductive system, since it develops mainly in young women and, therefore, negatively affects their reproductive function',
  'Endometriosis ( EM ) is morphologically characterized by the development of extrauterine endometrioid heterotopies , the major clinical symptoms of which is chronic pelvic pain , which is a serious problem not only in modern gynecology , but also in public health as a whole .',
  'Adenomyosis of the uterus is a serious problem for women of reproductive age because of its possible consequence of infertility .',
  'Gynecological cancers constitute a serious problem in the world .',
  'Ovary cancer is a disease charged of paradigms and a serious health problem .',
  'Ovarian cancer ( OC ) is a serious public health concern in the world .',
  'Endometriosis is a serious clinical problem among the women treated because of gynecological reasons .',
  'It is also a serious problem for endometrial cancer ( EC ) study .',
  'Background Severe forms of adenomyosis are a serious gynecological problem .',
  'Metastatic lesions within the ovary constitute a serious diagnostic problem in daily practice .',
  'Risk assessment for epithelial ovarian cancer : proposing a new approach to a deadly problem .',
  'Adenomyomectomy is conservative surgery that is now widely applied ; however , relapse is a serious problem after the operation .',
  'Nevertheless , since development of ovarian carcinoma in infertile women during infertility treatment is a serious concern for gynecologists , this review also covers important points for clinical practice , especially the issue of early detection of ovarian carcinoma .',
  'Ovarian tumor in pregnancy is a distressing problem for the obstetrician .',
  'The massive ovarian cyst ( greater than 25 pounds ) presents a challenging opportunity for surgical intervention and potential cure of a debilitating problem .',
  'Despite advances in cytotoxic chemotherapy and surgical cytoreduction , disease recurrence continues to be a troubling problem in patients with advanced-stage epithelial ovarian cancer ( EOC ) .',
  'Uterine leiomyomas ( LMs ) , currently the most common gynecological complaint around the world , are a serious medical , social and economic problem .',
  'Epithelial ovarian cancer is a serious public health problem worldwide with the highest mortality rate of all gynecologic cancers .',
  'While surgery is currently the treatment of choice for endometriosis , recurrence remains a serious problem , and its prevention is an unmet clinical need .',
  'The presence of a suspicious ovarian cyst with elevated cancer antigen 125 level in a woman of reproductive age poses a serious therapeutic dilemma .',
  'Ovarian cancer is a life-threatening diagnosis which poses multiple challenges .',
  'Ovarian cancer is a disease laden with paradigms , and it is a serious health problem .',
  'Resistance to chemotherapy poses a serious problem for the treatment of advanced epithelial ovarian cancer patients .',
  'Premature ovarian failure during chemotherapy is a serious problem for young women with cancer .',
  'Malignant tumors of the female reproductive system are a serious health and social problem , as they are the second most common cause of death among women , after breast cancer .',
  'Malignant tumors of the female reproductive system are a serious health and social problem , as they are the second most common cause of death among women , after breast cancer .',
  'Any cancer in pregnancy is a catastrophic event for the woman and her partner , and poses great challenges for the multidisciplinary team responsible for her care .',
  'Endometrial cancer remains , today , a serious problem , especially for postmenopausal women .',
  'Spinal tumors are rare in pregnancy , but they cause a serious problem in terms of continuing pregnancy .'],
 'firearm': ['Firearm-related violence is a significant public health issue in the US',
  'Gun violence is a serious public health concern that is currently grossly understudied .',
  'Background Firearm-related deaths are a serious public-health problem in South Africa , which has the second-highest rate of firearm-related deaths in the world .',
  'Pediatric firearm-related deaths and injuries are a serious societal problem .',
  'Weapon-related violence , especially the use of handguns , among adolescents is a serious public health concern .',
  'Firearm death and injury in children and adolescents is also a serious problem .',
  'Firearms are utilized in approximately half of all US suicides , making them a serious public health concern and a target of suicide prevention efforts .',
  'In summary , firearm injury poses a serious economic problem and is a substantial drain on health care providers and their resources .',
  'Gun violence is a serious public health concern , yet risk factors for gun violence involvement remain understudied .',
  'Firearm-related injuries are a serious public health problem in the United States .',
  'Consequently , reducing the mortality and complication rates from firearm injuries is still a serious problem .',
  'Firearm-related injuries pose a serious public health problem in the United States and are increasingly the focus of public health concern .',
  'Gun deaths and injuries in Canada are a serious public health problem , claiming more than 1200 lives each year and resulting in over 1000 hospitalizations .',
  'Pediatric firearm injuries are a serious and growing public health problem , constituting the second leading cause of death in children and adolescents in the United States .',
  'Firearm injuries , many of which involve the hand , wrist , or forearm , pose a serious public health concern in the United States in both medical and economic terms .',
  'Violent death is a serious problem in the United States .',
  'Weapon-related violent crime is a serious , complex , and multifaceted public health problem .',
  'Firearm-related deaths and injuries are a serious public health problem in California and the United States .'],
 'gun': ['Firearm-related violence is a significant public health issue in the US',
  'Gun violence is a serious public health concern that is currently grossly understudied .',
  'Background Firearm-related deaths are a serious public-health problem in South Africa , which has the second-highest rate of firearm-related deaths in the world .',
  'Pediatric firearm-related deaths and injuries are a serious societal problem .',
  'Weapon-related violence , especially the use of handguns , among adolescents is a serious public health concern .',
  'Firearm death and injury in children and adolescents is also a serious problem .',
  'Firearms are utilized in approximately half of all US suicides , making them a serious public health concern and a target of suicide prevention efforts .',
  'In summary , firearm injury poses a serious economic problem and is a substantial drain on health care providers and their resources .',
  'Gun violence is a serious public health concern , yet risk factors for gun violence involvement remain understudied .',
  'Firearm-related injuries are a serious public health problem in the United States .',
  'Consequently , reducing the mortality and complication rates from firearm injuries is still a serious problem .',
  'Firearm-related injuries pose a serious public health problem in the United States and are increasingly the focus of public health concern .',
  'Gun deaths and injuries in Canada are a serious public health problem , claiming more than 1200 lives each year and resulting in over 1000 hospitalizations .',
  'Pediatric firearm injuries are a serious and growing public health problem , constituting the second leading cause of death in children and adolescents in the United States .',
  'Firearm injuries , many of which involve the hand , wrist , or forearm , pose a serious public health concern in the United States in both medical and economic terms .',
  'Violent death is a serious problem in the United States .',
  'Weapon-related violent crime is a serious , complex , and multifaceted public health problem .',
  'Firearm-related deaths and injuries are a serious public health problem in California and the United States .'],
 'deaths': ['Firearm-related violence is a significant public health issue in the US',
  'Gun violence is a serious public health concern that is currently grossly understudied .',
  'Background Firearm-related deaths are a serious public-health problem in South Africa , which has the second-highest rate of firearm-related deaths in the world .',
  'Pediatric firearm-related deaths and injuries are a serious societal problem .',
  'Weapon-related violence , especially the use of handguns , among adolescents is a serious public health concern .',
  'Firearm death and injury in children and adolescents is also a serious problem .',
  'Firearms are utilized in approximately half of all US suicides , making them a serious public health concern and a target of suicide prevention efforts .',
  'In summary , firearm injury poses a serious economic problem and is a substantial drain on health care providers and their resources .',
  'Gun violence is a serious public health concern , yet risk factors for gun violence involvement remain understudied .',
  'Firearm-related injuries are a serious public health problem in the United States .',
  'Consequently , reducing the mortality and complication rates from firearm injuries is still a serious problem .',
  'Firearm-related injuries pose a serious public health problem in the United States and are increasingly the focus of public health concern .',
  'Gun deaths and injuries in Canada are a serious public health problem , claiming more than 1200 lives each year and resulting in over 1000 hospitalizations .',
  'Pediatric firearm injuries are a serious and growing public health problem , constituting the second leading cause of death in children and adolescents in the United States .',
  'Firearm injuries , many of which involve the hand , wrist , or forearm , pose a serious public health concern in the United States in both medical and economic terms .',
  'Violent death is a serious problem in the United States .',
  'Weapon-related violent crime is a serious , complex , and multifaceted public health problem .',
  'Firearm-related deaths and injuries are a serious public health problem in California and the United States .'],
 'weapon': ['Firearm-related violence is a significant public health issue in the US',
  'Gun violence is a serious public health concern that is currently grossly understudied .',
  'Background Firearm-related deaths are a serious public-health problem in South Africa , which has the second-highest rate of firearm-related deaths in the world .',
  'Pediatric firearm-related deaths and injuries are a serious societal problem .',
  'Weapon-related violence , especially the use of handguns , among adolescents is a serious public health concern .',
  'Firearm death and injury in children and adolescents is also a serious problem .',
  'Firearms are utilized in approximately half of all US suicides , making them a serious public health concern and a target of suicide prevention efforts .',
  'In summary , firearm injury poses a serious economic problem and is a substantial drain on health care providers and their resources .',
  'Gun violence is a serious public health concern , yet risk factors for gun violence involvement remain understudied .',
  'Firearm-related injuries are a serious public health problem in the United States .',
  'Consequently , reducing the mortality and complication rates from firearm injuries is still a serious problem .',
  'Firearm-related injuries pose a serious public health problem in the United States and are increasingly the focus of public health concern .',
  'Gun deaths and injuries in Canada are a serious public health problem , claiming more than 1200 lives each year and resulting in over 1000 hospitalizations .',
  'Pediatric firearm injuries are a serious and growing public health problem , constituting the second leading cause of death in children and adolescents in the United States .',
  'Firearm injuries , many of which involve the hand , wrist , or forearm , pose a serious public health concern in the United States in both medical and economic terms .',
  'Violent death is a serious problem in the United States .',
  'Weapon-related violent crime is a serious , complex , and multifaceted public health problem .',
  'Firearm-related deaths and injuries are a serious public health problem in California and the United States .'],
 'schizophrenia': ['Social difficulties are a hallmark of schizophrenia spectrum conditions, yet their background and exact nature remain contested',
  'The problem with many of these observations is that it is extremely difficult to distinguish movement disorders related to neuroleptic treatment from those that may have occurred spontaneously .',
  'A common and serious drawback of the conventional antipsychotics is their association with a range of motor disturbances : acute extrapyramidal symptoms , including parkinsonism , acute akathisia and acute dystonia ; and chronic motor problems such as tardive dyskinesia , chronic akathisia and tardive dystonia .',
  'A prominent drawback of antipsychotics is their negative impact on subjective well-being , initiative , and drive related to dopamine D2 blockade .',
  'Antipsychotic drug-induced tardive dyskinesia ( TD ) is a serious problem during psychopharmacologic treatment of schizophrenic patients .',
  'Since this is a serious clinical problem that may be further exacerbated in overweight schizophrenics , establishing animal models of AAP-induced adverse effects may contribute to clarifying the mechanisms underlying these effects .',
  'Auditory hallucinations are a serious problem for a large subgroup of psychotic patients who do not respond optimally to neuroleptic medication .',
  'Monosymptomatic hypochondriacal psychosis ( MHP ) is a form of psychosis characterized by the delusional idea that there is a serious problem in the skin or other body parts .',
  'Tardive dyskinesia caused by antipsychotic treatment is a severe problem not only in the management of schizophrenia , but also of affective disorders .',
  'Drug-induced bodyweight gain ( BWG ) is a serious concern in pharmacotherapy with second-generation antipsychotics .',
  'Neuroleptic-induced tardive dyskinesia ( TD ) continues to be a serious problem in the psychopharmacology of schizophrenia .',
  'This potential complication of treatment with certain antipsychotic agents requires careful study and could represent a serious public health problem .',
  'Schizophrenia is a serious public health concern and a leading cause of disability .',
  'Apart from the inadequacy of the plasma neuroleptic assay method , resistance to neuroleptic treatment in some schizophrenics presents a serious problem in studies looking into the plasma drug level versus clinical response correlation .',
  'Substance abuse by people with schizophrenia is a serious public health problem that is associated with poor treatment compliance , increased rates of relapse , and disruption of role functioning .',
  'Treatment-resistant schizophrenia is a serious clinical problem .',
  'As a severely and highly heritable psychotic disorder , schizophrenia has become a serious public health problem in modern society .',
  "Schizophrenia is a severe public health problem and one of the top ten causes of disability , affecting about 1.1 % of the world 's population .",
  'Impaired adherence to medication regimens is a serious concern for individuals with schizophrenia linked to relapse and poorer outcomes .',
  'NMS is a dangerous , drug-induced complication of neuroleptic administrations that can be a differential diagnostic problem .',
  'OSA is as well the risk factor for cardiovascular and metabolic diseases which are a serious clinical problem in mentally ill people and contribute to shortening of their expected lifespan .',
  'Psychotic disorders are a serious mental health problem .',
  'Schizophrenia is a serious public health problem that affects ∼1 % of the US population .',
  'Forensic patients with schizophrenia who fail to adhere to prescribed antipsychotic medication risk recidivism , which continues to be a serious concern .',
  'For clients who receive medical treatment for a severe and enduring mental health problem , antipsychotic medication is the first line of treatment .',
  'Early-onset first-episode psychosis ( EOP ) is a severe mental disorder that can pose a number of challenges to clinicians , young people and their families .',
  'Medication nonadherence in patients with schizophrenia presents a serious clinical problem .',
  'A serious problem in psychiatric practice is the lack of specific , objective biomarker-based assessments to guide diagnosis and treatment .',
  'Although noncompliance represents a serious concern in long-term schizophrenia treatment , a detailed information on the factors that impair compliance is still limited .',
  'Despite the introduction of atypical antipsychotic drugs , treatment-resistant symptoms still represent a serious problem in schizophrenia .',
  'Although the majority of CHD care indicators are achieved equally for patients who also have a serious mental health problem , there is a shortfall in identifying and treating raised cholesterol among patients with schizophrenia , despite their higher level of risk factors .',
  'Weight gain induced by atypical antipsychotics causes a serious health concern in the treatment of schizophrenic patients .',
  'Weight gain is a serious problem with recently introduced atypical antipsychotic agents .',
  'The heterogeneity within schizophrenia or the group of schizophrenias remains a vexing and limiting problem .',
  'Weight gain under olanzapine is a serious concern , and should be monitored closely and countered by active measures .',
  'Auditory hallucinations ( AH ) , the perception of sounds and voices in the absence of external stimuli , remain a serious problem for a large subgroup of patients with schizophrenia .',
  'Treatment-resistant schizophrenia ( TRS ) , the persistence of positive symptoms despite ≥2 trials of adequate dose and duration of antipsychotic medication with documented adherence , is a serious clinical problem with heterogeneous presentations .',
  'Although neuropsychiatric diseases impose a serious health and economic burden , their etiology and pathogenesis remain largely unknown because of the dearth of valid animal models and the challenges in investigating the pathophysiology in neuronal circuits .',
  'Antipsychotic-induced weight gain ( AIWG ) is a serious concern in therapy with antipsychotic medications .',
  'Somatic comorbidities are a serious problem in patients with severe mental illnesses .',
  'These findings suggest that the manifestation of tardive dyskinesia will become a serious problem in the investigation of psychotropic drug treatment .',
  'Postural instability is a serious concern in patients with schizophrenia-spectrum disorders since it is expected to increase the risk of falls that may lead to fractures .',
  'Antipsychotic nonadherence in psychotic disorders is a vexing clinical problem .',
  'Schizophrenia is a serious public health problem and is ranked among the most disabling diseases in the world .',
  'By examining the relative balance of effects , that is , relapse duration versus antipsychotic treatment intensity , this study sheds light on a troublesome dilemma that clinicians face .',
  'Schizophrenia with childhood and adolescent onset is a serious clinical/social problem .',
  'Loss of body weight is a serious health problem in schizophrenia patients with severe psychosis syndrome , especially the negative syndrome .',
  'Schizophrenia is a severe global health problem , with over half of such patients experiencing auditory verbal hallucinations ( AVHs ) .',
  'The authors suggest that vomiting among schizophrenic patients is usually underestimated and may at times be a serious clinical problem .',
  'Despite the development of second-generation antipsychotic drugs , treatment-resistant symptoms still represent a serious problem in schizophrenia .',
  'Antipsychotic-induced extrapyramidal adverse effects continue to be a serious problem in the treatment of psychotic disorders .',
  'In spite of early diagnosis and aggressive treatment , neuropsychiatric SLE may represent a serious problem of management .',
  'Schizophrenia is a severe psychiatric disorder with a core component of impaired cognitive function still remaining as one of the greatest challenges in the pharmacological treatment of the disorder .',
  'However , since the loss of body weight was more marked in T-506 than in the other two drugs , the side effect was thought to be a serious problem .',
  'Disordered interpersonal communication can be a serious problem in schizophrenia .',
  'While positron emission tomography ( PET ) studies have provided invaluable data on antipsychotic effects , selection bias remains a serious concern .',
  'Negative symptoms of schizophrenia constitute a serious diagnostic and therapeutic problem .'],
 'antipsychotic': ['Social difficulties are a hallmark of schizophrenia spectrum conditions, yet their background and exact nature remain contested',
  'The problem with many of these observations is that it is extremely difficult to distinguish movement disorders related to neuroleptic treatment from those that may have occurred spontaneously .',
  'A common and serious drawback of the conventional antipsychotics is their association with a range of motor disturbances : acute extrapyramidal symptoms , including parkinsonism , acute akathisia and acute dystonia ; and chronic motor problems such as tardive dyskinesia , chronic akathisia and tardive dystonia .',
  'A prominent drawback of antipsychotics is their negative impact on subjective well-being , initiative , and drive related to dopamine D2 blockade .',
  'Antipsychotic drug-induced tardive dyskinesia ( TD ) is a serious problem during psychopharmacologic treatment of schizophrenic patients .',
  'Since this is a serious clinical problem that may be further exacerbated in overweight schizophrenics , establishing animal models of AAP-induced adverse effects may contribute to clarifying the mechanisms underlying these effects .',
  'Auditory hallucinations are a serious problem for a large subgroup of psychotic patients who do not respond optimally to neuroleptic medication .',
  'Monosymptomatic hypochondriacal psychosis ( MHP ) is a form of psychosis characterized by the delusional idea that there is a serious problem in the skin or other body parts .',
  'Tardive dyskinesia caused by antipsychotic treatment is a severe problem not only in the management of schizophrenia , but also of affective disorders .',
  'Drug-induced bodyweight gain ( BWG ) is a serious concern in pharmacotherapy with second-generation antipsychotics .',
  'Neuroleptic-induced tardive dyskinesia ( TD ) continues to be a serious problem in the psychopharmacology of schizophrenia .',
  'This potential complication of treatment with certain antipsychotic agents requires careful study and could represent a serious public health problem .',
  'Schizophrenia is a serious public health concern and a leading cause of disability .',
  'Apart from the inadequacy of the plasma neuroleptic assay method , resistance to neuroleptic treatment in some schizophrenics presents a serious problem in studies looking into the plasma drug level versus clinical response correlation .',
  'Substance abuse by people with schizophrenia is a serious public health problem that is associated with poor treatment compliance , increased rates of relapse , and disruption of role functioning .',
  'Treatment-resistant schizophrenia is a serious clinical problem .',
  'As a severely and highly heritable psychotic disorder , schizophrenia has become a serious public health problem in modern society .',
  "Schizophrenia is a severe public health problem and one of the top ten causes of disability , affecting about 1.1 % of the world 's population .",
  'Impaired adherence to medication regimens is a serious concern for individuals with schizophrenia linked to relapse and poorer outcomes .',
  'NMS is a dangerous , drug-induced complication of neuroleptic administrations that can be a differential diagnostic problem .',
  'OSA is as well the risk factor for cardiovascular and metabolic diseases which are a serious clinical problem in mentally ill people and contribute to shortening of their expected lifespan .',
  'Psychotic disorders are a serious mental health problem .',
  'Schizophrenia is a serious public health problem that affects ∼1 % of the US population .',
  'Forensic patients with schizophrenia who fail to adhere to prescribed antipsychotic medication risk recidivism , which continues to be a serious concern .',
  'For clients who receive medical treatment for a severe and enduring mental health problem , antipsychotic medication is the first line of treatment .',
  'Early-onset first-episode psychosis ( EOP ) is a severe mental disorder that can pose a number of challenges to clinicians , young people and their families .',
  'Medication nonadherence in patients with schizophrenia presents a serious clinical problem .',
  'A serious problem in psychiatric practice is the lack of specific , objective biomarker-based assessments to guide diagnosis and treatment .',
  'Although noncompliance represents a serious concern in long-term schizophrenia treatment , a detailed information on the factors that impair compliance is still limited .',
  'Despite the introduction of atypical antipsychotic drugs , treatment-resistant symptoms still represent a serious problem in schizophrenia .',
  'Although the majority of CHD care indicators are achieved equally for patients who also have a serious mental health problem , there is a shortfall in identifying and treating raised cholesterol among patients with schizophrenia , despite their higher level of risk factors .',
  'Weight gain induced by atypical antipsychotics causes a serious health concern in the treatment of schizophrenic patients .',
  'Weight gain is a serious problem with recently introduced atypical antipsychotic agents .',
  'The heterogeneity within schizophrenia or the group of schizophrenias remains a vexing and limiting problem .',
  'Weight gain under olanzapine is a serious concern , and should be monitored closely and countered by active measures .',
  'Auditory hallucinations ( AH ) , the perception of sounds and voices in the absence of external stimuli , remain a serious problem for a large subgroup of patients with schizophrenia .',
  'Treatment-resistant schizophrenia ( TRS ) , the persistence of positive symptoms despite ≥2 trials of adequate dose and duration of antipsychotic medication with documented adherence , is a serious clinical problem with heterogeneous presentations .',
  'Although neuropsychiatric diseases impose a serious health and economic burden , their etiology and pathogenesis remain largely unknown because of the dearth of valid animal models and the challenges in investigating the pathophysiology in neuronal circuits .',
  'Antipsychotic-induced weight gain ( AIWG ) is a serious concern in therapy with antipsychotic medications .',
  'Somatic comorbidities are a serious problem in patients with severe mental illnesses .',
  'These findings suggest that the manifestation of tardive dyskinesia will become a serious problem in the investigation of psychotropic drug treatment .',
  'Postural instability is a serious concern in patients with schizophrenia-spectrum disorders since it is expected to increase the risk of falls that may lead to fractures .',
  'Antipsychotic nonadherence in psychotic disorders is a vexing clinical problem .',
  'Schizophrenia is a serious public health problem and is ranked among the most disabling diseases in the world .',
  'By examining the relative balance of effects , that is , relapse duration versus antipsychotic treatment intensity , this study sheds light on a troublesome dilemma that clinicians face .',
  'Schizophrenia with childhood and adolescent onset is a serious clinical/social problem .',
  'Loss of body weight is a serious health problem in schizophrenia patients with severe psychosis syndrome , especially the negative syndrome .',
  'Schizophrenia is a severe global health problem , with over half of such patients experiencing auditory verbal hallucinations ( AVHs ) .',
  'The authors suggest that vomiting among schizophrenic patients is usually underestimated and may at times be a serious clinical problem .',
  'Despite the development of second-generation antipsychotic drugs , treatment-resistant symptoms still represent a serious problem in schizophrenia .',
  'Antipsychotic-induced extrapyramidal adverse effects continue to be a serious problem in the treatment of psychotic disorders .',
  'In spite of early diagnosis and aggressive treatment , neuropsychiatric SLE may represent a serious problem of management .',
  'Schizophrenia is a severe psychiatric disorder with a core component of impaired cognitive function still remaining as one of the greatest challenges in the pharmacological treatment of the disorder .',
  'However , since the loss of body weight was more marked in T-506 than in the other two drugs , the side effect was thought to be a serious problem .',
  'Disordered interpersonal communication can be a serious problem in schizophrenia .',
  'While positron emission tomography ( PET ) studies have provided invaluable data on antipsychotic effects , selection bias remains a serious concern .',
  'Negative symptoms of schizophrenia constitute a serious diagnostic and therapeutic problem .'],
 'doctors': ['There is growing concern over a future shortfall in provision of UK otolaryngology consultants',
  'The UK faces geographical variation in the recruitment of doctors',
  'Although recruiting highly qualified, diverse applicants into cardiothoracic surgery remains a national priority, their characteristics remain unknown',
  "The hazy doc shortage . There 's a serious problem , but lack of clarity forestalls solutions .",
  'The shortage of future forensic pathologists is a serious problem both in Japan and overseas .',
  'Shortage of pathologists in Canada : crisis or just a serious problem ?',
  '[ Manpower shortage in oral and maxillofacial surgery -- a serious problem in the Netherlands ] .',
  'A shortage of surgeons has been a serious problem in recent years .',
  'The shortage of medical doctors is now a serious social problem in Japan .',
  'The shortage of physicians has become a serious problem in Japan .',
  'The decrease in the number of physician investigators is a serious national problem .',
  'The shortage of physicians in Japan is a serious concern , particularly in specialties like pediatrics .',
  'Japanese medical schools currently confront a serious problem endangering the carrier path of medical students or doctors to the medical research activities in academic institutions .',
  'This study confirms the recent loss of academic training positions , leading to a serious concern about the future of academic paediatrics in some UK centres .',
  'There is a serious concern that the pipeline for the production of the physician workforce is inadequate to meet future needs .',
  'A vexing problem in health policy is getting the right number of physicians in the right specialties in the right locations at the right time .',
  'Because the numbers of doctors were decreased even in University hospital , large numbers of hospital including special hospital for neurological diseases are faced with a serious problem of the doctorless .',
  'There is general agreement within pathology that there is a serious problem in the recruitment of US medical graduates into the field .',
  'Due to a -- depending on the region -- already existent or predicted lack of general practitioners , the German health care is confronted with a serious problem .'],
 'traffic': ['Among factors potentially contributing to accidents involving heavy vehicles, reverse alarms can be difficult to localize in space, leading to errors in identifying the source of danger',
  'The problem with M5P for accident duration prediction , however , is that whereas linear regression assumes that the conditional distribution of accident durations is normally distributed , the distribution for a " time-to-an-event " is almost certainly nonsymmetrical .',
  'Pedestrian safety is a serious concern at busy intersections and pedestrian campuses across the nation .',
  'The streets , however , are seriously eroded and probably can not be maintained for vehicle usage , which does not pose a serious problem to the residents as none possess automobiles or trucks .',
  'In Saudi Arabia , road traffic accidents ( RTA ) are becoming a serious public health problem .',
  'Motor vehicle collisions ( MVCs ) that result in one or more fatalities on the 400-series Highways represent a serious public health problem in Ontario , and were estimated to have cost $ 11 billion in 2004 .',
  'In Saudi Arabia , with its rapid expansion of road construction and increase in the number of vehicles , road traffic accidents are becoming a serious public health problem .',
  'Car accidents due to unexpected forward or backward runaway by older drivers are a serious social problem .',
  'Traffic accidents as a serious health problem in selected developing countries of the Americas .',
  'Having a severe traffic safety problem in Turkey , a need to assess both the comprehensibility of internationally accepted traffic signs and current level of driver education , was the main motivation behind this study .',
  'Ophidic accidents are a serious health problem for tropical countries , because are responsible for the high incidence of morbidity and mortality .',
  'However , accidents are a serious concern with scooter use .',
  'The study reveals that traffic traumatism continues to be a serious problem for all international community .',
  'Disease severity was directly proportional to traffic-accident risk , and thus represents a serious social problem .',
  'Road traffic accidents ( RTAs ) represent a serious problem globally causing losses in many ways .',
  'In the past decades , extremely serious road accidents with a death toll over ten in each have become a severe public health problem in China .',
  'Road traffic accidents represent a serious problem in the Kingdom of Saudi Arabia ( KSA ) , with rates of such accidents far exceeding the rates in developed nations .',
  'A serious health problem is developing from automobile collisions caused by distracted drivers .',
  'Traffic crashes are a serious public health and socio-economic problem , and they are one of leading causes of death of males in Serbia .',
  'Pedestrian-vehicle collision is a serious public health problem today in Taiwan , but this issue of pedestrian safety has received relatively little attention .',
  'However , traffic injuries remain a serious public health problem for the elderly and effective measures are required to reduce their incidence .',
  'Work zone traffic safety under adverse weather conditions has been a serious concern for drivers and transportation agencies .',
  'All-terrain vehicles ( ATVs ) on the road : a serious traffic safety and public health concern .',
  'The Government White Paper Saving Lives : Our Healthier Nation ( 1999 ) provides a clear indication that accidents are a serious public health problem and have been targeted by the Department of Health as a key area for prevention over the next 10 years .',
  'In Saudi Arabia , road traffic crashes are becoming a serious public health problem and there are no recent , large-scale , published reports discussing maternal and fetal injuries .',
  'Incidents of road rage are frequently reported in the media , yet despite claims that aggression on congested roads is a serious social problem , little empirical research has explored the question of whether people really do become more aggressive behind the wheel .',
  'Associated injuries constitute a serious problem with progressively increasing car accident traumatism .',
  'Motor vehicle collisions ( MVCs ) resulting in death have been a serious concern for many years .',
  'Road accidents have become a serious social problem .',
  'All-terrain vehicle ( ATV ) crashes are a serious public health and safety concern .',
  'Emergency vehicle crashes are a serious nationwide problem , causing injury and death to emergency responders and citizens .',
  'While there is a strong emphasis for older people to maintain their mobility , the safety of older drivers is a serious community concern .',
  'Injury resulting from accident is a serious public health problem in Sweden , as it is in the rest of the world .',
  'Speeding-related crashes continue to be a serious problem in the United States . According to the National Highway Traffic Safety Administration , 26 % of all fatal crashes in 2017 had speeding as a contributing factor .',
  'The prevention of road traffic accidents should be considered a serious public health concern , since they are the eighth leading cause of death globally and the main cause of death for young people aged 15 - 29 .',
  'Road rage has become a serious concern in many countries , and preventive efforts are required .',
  'Deaths and injuries resulted from road traffic crashes remain a serious problem globally , and current trends suggest that this will continue to be the case in the foreseeable future mainly in developing countries .',
  'Road traffic injury remains a serious public health problem in children and young people in Lithuania , which requires a high priority .',
  'Road traffic injuries represent a serious public health problem and are one of leading cause of death , injury and disability around the world .',
  'Fatalities and injuries resulting from road traffic crashes is always a serious problem .',
  'Injuries due to accidents are a serious public health problem in Sweden as in the rest of the world .',
  '[ Motor vehicle accidents , a serious health problem in Mexico City ] .',
  'The trauma caused by motorcycle accidents affects a large number of victims and is a serious public health problem in Brazil .',
  'Fatal motorcycle crashes : a serious public health problem in Brazil .',
  'Side impacts are a serious automotive injury problem ; they represent about 30 % of all fatalities for passenger vehicle occupants .',
  'The disabling injuries inflicted during road traffic accidents ( RTA ) create a serious challenge for the public health services and are at the same time a major socio-economic problem in the majority of the countries throughout the world .',
  'Motorcyclist injury in China is a serious public health problem .',
  'The findings implicate that the health status of taxi operators in Tshwane was a serious concern and urgent concerted effort is needed to engage in lifestyle modification of taxi drivers .',
  'Wrong-way crashes on limited access highways continue to be a serious problem for state highway agencies and communities .',
  'Road accidents are a serious problem of the modern world .',
  'Collisions between emergency vehicles for emergency medical services ( EMS ) and public road users have been a serious problem , impacting on the safety of road users , emergency medical technicians ( EMTs ) , and the patients on board .',
  'Despite overall improvements in road traffic safety , pedestrian accidents continue to be a serious public health problem .',
  'Based on data that are at best conservative estimates , Nigeria is a country with a serious and growing road accident problem that is about the worst in the world .',
  'In recent years , given the advance in connectivity and social networks , the use of smartphones while driving has become more frequent and a serious problem for safety .',
  'Road traffic injuries are a serious public health problem worldwide .',
  'Rollover crashes are a serious public health problem in United States , with one third of traffic fatalities occurring in crashes where rollover occurred .',
  'This first Swiss study points out that DUID is a serious problem on the roads in Switzerland .',
  'Road traffic injuries have persisted as a serious public health problem and much of the health burden is in developing countries .'],
 'accidents': ['Among factors potentially contributing to accidents involving heavy vehicles, reverse alarms can be difficult to localize in space, leading to errors in identifying the source of danger',
  'The problem with M5P for accident duration prediction , however , is that whereas linear regression assumes that the conditional distribution of accident durations is normally distributed , the distribution for a " time-to-an-event " is almost certainly nonsymmetrical .',
  'Pedestrian safety is a serious concern at busy intersections and pedestrian campuses across the nation .',
  'The streets , however , are seriously eroded and probably can not be maintained for vehicle usage , which does not pose a serious problem to the residents as none possess automobiles or trucks .',
  'In Saudi Arabia , road traffic accidents ( RTA ) are becoming a serious public health problem .',
  'Motor vehicle collisions ( MVCs ) that result in one or more fatalities on the 400-series Highways represent a serious public health problem in Ontario , and were estimated to have cost $ 11 billion in 2004 .',
  'In Saudi Arabia , with its rapid expansion of road construction and increase in the number of vehicles , road traffic accidents are becoming a serious public health problem .',
  'Car accidents due to unexpected forward or backward runaway by older drivers are a serious social problem .',
  'Traffic accidents as a serious health problem in selected developing countries of the Americas .',
  'Having a severe traffic safety problem in Turkey , a need to assess both the comprehensibility of internationally accepted traffic signs and current level of driver education , was the main motivation behind this study .',
  'Ophidic accidents are a serious health problem for tropical countries , because are responsible for the high incidence of morbidity and mortality .',
  'However , accidents are a serious concern with scooter use .',
  'The study reveals that traffic traumatism continues to be a serious problem for all international community .',
  'Disease severity was directly proportional to traffic-accident risk , and thus represents a serious social problem .',
  'Road traffic accidents ( RTAs ) represent a serious problem globally causing losses in many ways .',
  'In the past decades , extremely serious road accidents with a death toll over ten in each have become a severe public health problem in China .',
  'Road traffic accidents represent a serious problem in the Kingdom of Saudi Arabia ( KSA ) , with rates of such accidents far exceeding the rates in developed nations .',
  'A serious health problem is developing from automobile collisions caused by distracted drivers .',
  'Traffic crashes are a serious public health and socio-economic problem , and they are one of leading causes of death of males in Serbia .',
  'Pedestrian-vehicle collision is a serious public health problem today in Taiwan , but this issue of pedestrian safety has received relatively little attention .',
  'However , traffic injuries remain a serious public health problem for the elderly and effective measures are required to reduce their incidence .',
  'Work zone traffic safety under adverse weather conditions has been a serious concern for drivers and transportation agencies .',
  'All-terrain vehicles ( ATVs ) on the road : a serious traffic safety and public health concern .',
  'The Government White Paper Saving Lives : Our Healthier Nation ( 1999 ) provides a clear indication that accidents are a serious public health problem and have been targeted by the Department of Health as a key area for prevention over the next 10 years .',
  'In Saudi Arabia , road traffic crashes are becoming a serious public health problem and there are no recent , large-scale , published reports discussing maternal and fetal injuries .',
  'Incidents of road rage are frequently reported in the media , yet despite claims that aggression on congested roads is a serious social problem , little empirical research has explored the question of whether people really do become more aggressive behind the wheel .',
  'Associated injuries constitute a serious problem with progressively increasing car accident traumatism .',
  'Motor vehicle collisions ( MVCs ) resulting in death have been a serious concern for many years .',
  'Road accidents have become a serious social problem .',
  'All-terrain vehicle ( ATV ) crashes are a serious public health and safety concern .',
  'Emergency vehicle crashes are a serious nationwide problem , causing injury and death to emergency responders and citizens .',
  'While there is a strong emphasis for older people to maintain their mobility , the safety of older drivers is a serious community concern .',
  'Injury resulting from accident is a serious public health problem in Sweden , as it is in the rest of the world .',
  'Speeding-related crashes continue to be a serious problem in the United States . According to the National Highway Traffic Safety Administration , 26 % of all fatal crashes in 2017 had speeding as a contributing factor .',
  'The prevention of road traffic accidents should be considered a serious public health concern , since they are the eighth leading cause of death globally and the main cause of death for young people aged 15 - 29 .',
  'Road rage has become a serious concern in many countries , and preventive efforts are required .',
  'Deaths and injuries resulted from road traffic crashes remain a serious problem globally , and current trends suggest that this will continue to be the case in the foreseeable future mainly in developing countries .',
  'Road traffic injury remains a serious public health problem in children and young people in Lithuania , which requires a high priority .',
  'Road traffic injuries represent a serious public health problem and are one of leading cause of death , injury and disability around the world .',
  'Fatalities and injuries resulting from road traffic crashes is always a serious problem .',
  'Injuries due to accidents are a serious public health problem in Sweden as in the rest of the world .',
  '[ Motor vehicle accidents , a serious health problem in Mexico City ] .',
  'The trauma caused by motorcycle accidents affects a large number of victims and is a serious public health problem in Brazil .',
  'Fatal motorcycle crashes : a serious public health problem in Brazil .',
  'Side impacts are a serious automotive injury problem ; they represent about 30 % of all fatalities for passenger vehicle occupants .',
  'The disabling injuries inflicted during road traffic accidents ( RTA ) create a serious challenge for the public health services and are at the same time a major socio-economic problem in the majority of the countries throughout the world .',
  'Motorcyclist injury in China is a serious public health problem .',
  'The findings implicate that the health status of taxi operators in Tshwane was a serious concern and urgent concerted effort is needed to engage in lifestyle modification of taxi drivers .',
  'Wrong-way crashes on limited access highways continue to be a serious problem for state highway agencies and communities .',
  'Road accidents are a serious problem of the modern world .',
  'Collisions between emergency vehicles for emergency medical services ( EMS ) and public road users have been a serious problem , impacting on the safety of road users , emergency medical technicians ( EMTs ) , and the patients on board .',
  'Despite overall improvements in road traffic safety , pedestrian accidents continue to be a serious public health problem .',
  'Based on data that are at best conservative estimates , Nigeria is a country with a serious and growing road accident problem that is about the worst in the world .',
  'In recent years , given the advance in connectivity and social networks , the use of smartphones while driving has become more frequent and a serious problem for safety .',
  'Road traffic injuries are a serious public health problem worldwide .',
  'Rollover crashes are a serious public health problem in United States , with one third of traffic fatalities occurring in crashes where rollover occurred .',
  'This first Swiss study points out that DUID is a serious problem on the roads in Switzerland .',
  'Road traffic injuries have persisted as a serious public health problem and much of the health burden is in developing countries .'],
 'pressure': ['Joints withstand huge forces, but little is known about subchondral pressures and perfusion during loading',
  'Pressure injury is a serious problem and is common in critical care units .',
  'Increasing ambient pressures do present a serious problem to BH deep divers , because the semi-rigid thorax prevents the deformation required by the Boyle-Mariotte law .',
  'Despite growing evidence and directives for pressure injury prevention , implementation of preventative strategies is suboptimal , and pressure injuries remain a serious problem in hospitals .',
  'Pressure injury ( PI ) is a serious problem in health care settings globally .',
  'Hospital-acquired pressure injuries are a serious problem among critical care patients .',
  'Surgery-related pressure injury ( SRPI ) is a serious problem in patients who undergo cardiovascular surgery .',
  'Hospital-acquired pressure injuries are a serious problem among critical care patients .',
  'Although HPCs benefit patients , their delamination during use is a serious safety concern .',
  'As this phenomenon poses a serious safety problem for medical personnel as well as for the product itself , an investigation was initiated to identify the root cause of the overpressure .',
  'Hospital-acquired pressure injuries ( HAPIs ) represent a serious clinical and economic problem .',
  'Device-related pressure injury ( DRPI ) is a serious problem that is affecting professionals working on the front lines against COVID-19 due to the prolonged use of personal protective equipment ( PPE ) .'],
 'pressures': ['Joints withstand huge forces, but little is known about subchondral pressures and perfusion during loading',
  'Pressure injury is a serious problem and is common in critical care units .',
  'Increasing ambient pressures do present a serious problem to BH deep divers , because the semi-rigid thorax prevents the deformation required by the Boyle-Mariotte law .',
  'Despite growing evidence and directives for pressure injury prevention , implementation of preventative strategies is suboptimal , and pressure injuries remain a serious problem in hospitals .',
  'Pressure injury ( PI ) is a serious problem in health care settings globally .',
  'Hospital-acquired pressure injuries are a serious problem among critical care patients .',
  'Surgery-related pressure injury ( SRPI ) is a serious problem in patients who undergo cardiovascular surgery .',
  'Hospital-acquired pressure injuries are a serious problem among critical care patients .',
  'Although HPCs benefit patients , their delamination during use is a serious safety concern .',
  'As this phenomenon poses a serious safety problem for medical personnel as well as for the product itself , an investigation was initiated to identify the root cause of the overpressure .',
  'Hospital-acquired pressure injuries ( HAPIs ) represent a serious clinical and economic problem .',
  'Device-related pressure injury ( DRPI ) is a serious problem that is affecting professionals working on the front lines against COVID-19 due to the prolonged use of personal protective equipment ( PPE ) .'],
 'ckd': ['Renal infarction is a rare and usually underdiagnosed entity',
  'Chronic kidney disease is a growing global health problem',
  'A major problem for patients with kidney disease is that most chronic renal diseases progress to endstage renal failure .',
  'The primary problem with eGFR is that the non-GFR determinants of serum creatinine and cystatin C , as well as their surrogates ( age , sex , and race ) , associate with CKD risk factors and outcomes .',
  'A major problem for patients with kidney disease and their physicians is that most chronic renal diseases progress to global glomerular sclerosis and end-stage renal failure .',
  'Micronutrient depletion is a major drawback of high-dose continuous renal replacement therapy ( CRRT ) .',
  'Chronic kidney disease ( CKD ) is a serious public health problem .',
  'End-stage renal disease ( ESRD ) is a devastating medical , social , and economic problem .',
  'The prevalence of chronic kidney disease ( CKD ) as a serious public health problem is growing in the elderly .',
  'Although pediatric end-stage renal disease affects a small number of children , it is a serious and growing health problem in the United States .',
  'End-stage renal disease is a troublesome health problem worldwide .',
  'Kidney disease represents a serious global health problem .',
  "Chronic kidney disease ( CKD ) is a serious health problem due to high mortality and morbidity , negative impact on the patients ' quality of life ( QOL ) , high diagnostic and therapeutic cost , and the burden on society .",
  'Chronic kidney disease ( CKD ) , impairment of kidney function , is a serious public health problem , and the assessment of genetic factors influencing kidney function has substantial clinical relevance .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem throughout the world and is one of the most potent known risk factors for cardiovascular disease , which is the leading cause of morbidity and mortality in this patient population .',
  'Clinical conference : a case of polycystic kidney , simulating a severe feeding problem .',
  'Malnutrition and loss of appetite represent a serious problem in children with chronic renal failure .',
  'Chronic renal failure ( CRF ) is a serious clinical problem and currently there are no adequate therapeutic strategies for treatment .',
  'Chronic kidney disease is a serious health problem caused by involvement of a large number of patients with kidney injury , especially in industrial countries .',
  'CIN is a serious clinical problem associated with increased morbidity and mortality , particularly in patients with chronic renal failure ( see the Case Report ) .',
  'Epidemiological investigations have shown that CKD has become a serious global health problem .',
  'Rhabdomyolysis is a serious problem that must be recognized early to avoid grave renal consequences .',
  'A severe , chronic and irreversible kidney disease affecting discrete rural populations in the Balkan Peninsula countries , Balkan endemic nephropathy ( BEN ) has been a scientific puzzle for more than half a century .',
  'Renal disease becomes a serious problem for adults with TSC .',
  'Renal disease becomes a serious problem for adults with TSC .',
  'Data on the epidemiology of chronic kidney disease ( CKD ) , which is a serious health problem and refers to a condition related to irreversible kidney damage that further progress to end-stage renal disease in children , are insufficient and data that are available were based on hospital records .',
  'As about 50 % cases presented with varying degree of renal insufficiency , many ending with ESRD , IgA nephropathy can be considered as a serious problem in India .',
  'In Belgium , AN still remains a serious problem with a prevalence of 18 % in dialysis patients .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem throughout the world and is one of the most potent known risk factors for cardiovascular disease .',
  'Although fatigue among the dialysis population is known as a severe and debilitating health problem , this symptom is often under recognized and undertreated .',
  'Chronic renal failure ( CRF ) represents a serious medical problem .',
  "Chronic kidney disease ( CKD ) is still a serious health problem in children with increasing morbidity and affecting children 's quality of life ( QoL ) .",
  'End-stage renal disease ( ESRD ) is a serious health problem worldwide .',
  'It accounts for 8 - 10 % of the cases of end-stage renal disease worldwide , thus representing a serious medical , economical and social problem .',
  'Chronic kidney disease poses a serious health problem worldwide with increasing prevalence and lack of effective treatment .',
  'Chronic renal failure , particularly end-stage renal disease , is a serious health problem associated with a high mortality rate .',
  'Chronic kidney disease has become a serious public health problem in China .',
  'Chronic kidney disease ( CKD ) represents a serious public health concern .',
  'In 2013 , the PAHO Member States recognized the epidemic of chronic kidney disease of non-traditional causes ( CKDnT ) as a serious public health problem .',
  'Cancer presents a growing trend , and chronic kidney disease emerges as a serious health problem .',
  'End-stage renal disease ( ESRD ) is a serious public health problem .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem ; the number of people with impaired renal function is rapidly rising , especially in industrialized countries .',
  'Despite of unquestionable progress in heamodialysis treatment quite high morbidity and mortality still remain a serious problem among pediatric patients .',
  'The progression of chronic kidney disease is accompanied by multi-organ disorders , among which cardiovascular diseases have the status of a serious clinical problem .',
  'Chronic renal failure is a devastating medical , social , and economic problem for patients and their families in India and Pakistan .',
  'Terminal chronic kidney disease courses with high mortality and is a serious public health problem on a global scale .',
  'Steady increase in the prevalence of chronic kidney disease ( CKD ) is a serious public health problem , since CKD potentially leads to the development of end-stage renal disease ( ESRD ) that requires high-cost replacement therapy and is closely associated with increased risk of developing cardiovascular diseases ( CVD ) , which are the cause of death in most patients .',
  'End-stage renal disease represents a serious public health problem in Jalisco , Mexico .',
  'Chronic kidney disease ( CKD ) is a serious medical problem and public health issue in Taiwan .',
  'Despite their low prevalence , genetic kidney diseases ( GKD ) still represent a serious health problem .',
  'End-stage renal disease ( ESRD ) is a serious public health problem in Guangxi , a province of south China .',
  'Despite increased prevalence of renal insufficiency in CABG patients , studies show that in most cases , this is not a serious problem and it is easily treatable .',
  'The number of patients with end-stage renal disease ( ESRD ) has been increasing , with dialysis treatment being a serious economic problem .',
  'CKD has become a severe public health problem in Zhejiang Province , and metabolic diseases may increase the risk of CKD in Zhejiang population .',
  'End-stage renal disease has steadily increased in prevalence and incidence ( 478.2 and 168.7 pmp , respectively ) and is emerging as a devastating medical , social , and economic problem for patients , families , and national health systems .',
  'These markers are also elevated in end-stage renal disease ( ESRD ) , which constitutes a serious public health problem .',
  'Moreover , the global prevalence of patients with chronic kidney disease is gradually increasing , which poses a serious public health problem .',
  '[ Hemodialysis as a heavy burden on the health insurance system . A serious problem to smaller insurance groups ] .',
  'Renal insufficiency is a serious medical and public health problem worldwide .',
  'Protein-energy wasting ( PEW ) , a syndrome involving adverse changes in nutrition and body composition , is a serious problem associated with morbidity and mortality in patients with end-stage renal disease ( ESRD ) .',
  'Chronic renal disease constitutes a serious worldwide clinical problem .',
  'Chronic kidney disease ( CKD ) is a serious public health problem in Taiwan and the world .',
  'Over the last 20 years , many reports have described an excess of cases of chronic kidney disease ( CKD ) in the Pacific coastal area of Central America , mainly affecting male farmworkers and signaling a serious public health problem .',
  'Chronic kidney disease ( CKD ) has become a serious public health problem because of its associated morbidity , premature mortality , and attendant healthcare costs .',
  'Latent chronic kidney disease ( CKD ) population appears to be a serious health problem in Japan .',
  'Renal disease is a serious health problem , with increasing incidence and prevalence .',
  'Triage in civilian practice first became a serious issue with the development of dialysis for chronic renal failure in the 1960s and the problem of the allocation of this scarce and very expensive treatment .',
  'DN is a serious public health concern because it is the leading cause of end stage renal disease ( ESRD ) in most developed countries and is associated with increased cardiovascular mortality and morbidity .',
  'Chronic kidney disease ( CKD ) , defined as reduced glomerular filtration rate and/or proteinuria , is a serious worldwide health problem .',
  'Chronic kidney disease ( CKD ) poses a serious public health problem worldwide .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem ; the number of people with impaired renal function is rapidly rising .',
  'When progressing toward kidney failure , it is becoming a serious public health problem .',
  'Chronic renal failure is a serious health problem in the United States and other developed countries , and large amounts of public funds are being expended for what is essentially palliative treatment of this disease .',
  'Uremia , the result of renal failure , is a serious clinical problem .',
  'In El Salvador , chronic kidney disease is a serious and growing public health problem .',
  'Chronic kidney disease is a serious health problem in El Salvador .',
  'Chronic lymphocytic leukemia ( CLL ) in association with glomerulonephritis ( GN ) and renal failure is a serious problem in terms of therapy .',
  'End stage renal disease patients is a serious problem all around the world .',
  'Chronic kidney disease ( CKD ) has emerged as a serious public health problem worldwide .',
  'Chronic kidney disease ( CKD ) represents a serious concern for the Mexican population since the main predisposing diseases ( diabetes , hypertension , etc . ) have a high prevalence in the country .',
  'Chronic kidney disease ( CKD ) is considered a serious public health problem , both in Brazil and worldwide , with an increasing number of cases observed inrecent years .',
  'End stage renal disease ( ESRD ) is a devastating medical , social and economic problem in any community and needs dedicated supervision and health care .',
  'Chronic kidney disease ( CKD ) is a serious universal problem that is the main risk for several diseases including cardiovascular disease .',
  'Health professionals perceived CKD as a serious and increasing problem in the region , primarily affecting young men working as manual laborers .',
  'In the recent times , Chronic Kidney Diseases ( CKDs ) are emerging as a serious problem all over the world along with diabetes mellitus and hypertension .',
  'Wasting of lean tissue as a consequence of metabolic acidosis is a serious problem in patients with chronic renal failure .',
  'Late presentation ( LP ) of chronic kidney disease ( CKD ) patients to nephrologist is a serious problem worldwide with persistent high prevalence despite known benefits of early nephrology care .',
  'End-stage renal disease represents a serious public health problem in Mexico .',
  'Chronic kidney disease ( CKD ) is a serious health problem with high morbidity and mortality , mainly attributable to cardiovascular risk .',
  'Hypercoagulability , a serious problem in patients with ESRD on maintenance hemodialysis , and its correction after kidney transplantation .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem throughout the world and is one of the most potent known risk factors for cardiovascular disease ( CVD ) which is considered the leading cause of morbidity and mortality in this cohort of patients .',
  'Kidney disease is a serious problem that adversely affects human health , but critical knowledge is lacking on how to effectively treat established chronic kidney disease .',
  'In patients with autosomal dominant polycystic kidney disease ( ADPKD ) , massive renal enlargement is a serious problem .',
  'Epidemiological data show that chronic kidney disease ( CKD ) is a serious social problem and nowadays is included amongst civilisation diseases .',
  'End-stage renal disease ( ESRD ) is a severe health concern over the world .',
  "Chronic kidney disease ( CKD ) is a serious public health problem and its prevalence is growing in many countries , often related to issues resulting from the lifestyle in growing economies and the population 's life expectancy .",
  'Nonadherence to different aspects of ESRD continues to be a serious problem among dialysis patients , and it is closely linked to depression and anxiety .',
  'the cost of chronic kidney disease requires a large amount of economic resources , and is becoming a serious problem for health services and families .',
  'Chronic kidney disease ( CKD ) represents a serious public health problem due to the increase in incidence and prevalence of this disease worldwide .',
  "Chronic renal failure is a severe clinical problem which has some significant socioeconomic impact worldwide and hemodialysis is an important way to maintain patients ' health state , but it seems difficult to get better in short time .",
  'The inclining incidence of chronic kidney disease which has led to high mortality and immense medical burden over the past decades has become a distressing concern in epidemiology .',
  'Chronic kidney disease ( CKD ) is a serious health problem worldwide .',
  'However , even the asymptomatic proteinuria , when profuse , may be a serious problem because it predisposes to arterial thromboembolism and eventually contributes to the deterioration of the body condition .',
  'Chronic kidney disease ( CKD ) is a severe health problem worldwide , and vascular calcification ( VC ) contributes substantially to the cardiovascular morbidity and high mortality of CKD .',
  'Chronic kidney disease ( CKD ) is considered a serious worldwide public health problem , but data from developing countries are extremely limited .'],
 'kidney': ['Renal infarction is a rare and usually underdiagnosed entity',
  'Chronic kidney disease is a growing global health problem',
  'A major problem for patients with kidney disease is that most chronic renal diseases progress to endstage renal failure .',
  'The main problem with cyclosporine is that in many responders proteinuria relapses when the drug is stopped .',
  'The primary problem with eGFR is that the non-GFR determinants of serum creatinine and cystatin C , as well as their surrogates ( age , sex , and race ) , associate with CKD risk factors and outcomes .',
  'A major problem for patients with kidney disease and their physicians is that most chronic renal diseases progress to global glomerular sclerosis and end-stage renal failure .',
  'Cyclosporine A ( CsA ) is a potent immunosuppressant with the drawback of renal side effects .',
  'Micronutrient depletion is a major drawback of high-dose continuous renal replacement therapy ( CRRT ) .',
  'Cyclosporine A ( CsA ) is a potent immunosuppressant with the drawback of renal side-effects .',
  'Postischemic renal failure is a severe problem following cadaveric renal transplantation , especially if the kidney has been harvested from a non-heartbeating donor , and thereby subjected to periods of both warm and cold ischemia .',
  'Acute kidney injury ( AKI ) is a serious problem in critically ill patients of intensive care units .',
  'Chronic kidney disease ( CKD ) is a serious public health problem .',
  'End-stage renal disease ( ESRD ) is a devastating medical , social , and economic problem .',
  'The prevalence of chronic kidney disease ( CKD ) as a serious public health problem is growing in the elderly .',
  'Although pediatric end-stage renal disease affects a small number of children , it is a serious and growing health problem in the United States .',
  'End-stage renal disease is a troublesome health problem worldwide .',
  'Kidney disease represents a serious global health problem .',
  'Acute kidney injury ( AKI ) remains a serious clinical problem in the intensive care unit ( ICU ) .',
  'Reconstruction of the urinary tract because of ureteral stricture after kidney transplantation is a serious problem .',
  "Chronic kidney disease ( CKD ) is a serious health problem due to high mortality and morbidity , negative impact on the patients ' quality of life ( QOL ) , high diagnostic and therapeutic cost , and the burden on society .",
  'Chronic kidney disease ( CKD ) , impairment of kidney function , is a serious public health problem , and the assessment of genetic factors influencing kidney function has substantial clinical relevance .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem throughout the world and is one of the most potent known risk factors for cardiovascular disease , which is the leading cause of morbidity and mortality in this patient population .',
  'Clinical conference : a case of polycystic kidney , simulating a severe feeding problem .',
  'DIN accounts for 18 - 27 % of community- and hospital-acquired episodes of acute kidney injury ( AKI ) and is a serious concern during development of novel therapeutic drugs .',
  'Acute kidney injury is a serious global health problem and determinant of morbidity and mortality .',
  'Malnutrition and loss of appetite represent a serious problem in children with chronic renal failure .',
  'Chronic renal failure ( CRF ) is a serious clinical problem and currently there are no adequate therapeutic strategies for treatment .',
  'While sirolimus ( SRL ) is thought to be a non-nephrotoxic agent , cyclosporine A ( CsA ) toxicity is a serious problem in kidney transplantation .',
  'Acute kidney injury ( AKI ) is a serious clinical problem with high morbidity and mortality .',
  'Ischemic acute kidney injury ( AKI ) is a serious clinical problem and no efficient therapeutics is available in clinic now .',
  'Chronic kidney disease is a serious health problem caused by involvement of a large number of patients with kidney injury , especially in industrial countries .',
  'CIN is a serious clinical problem associated with increased morbidity and mortality , particularly in patients with chronic renal failure ( see the Case Report ) .',
  'Despite huge progress in transplantation , renal transplantation remains a serious problem since patients treated with the calcineurin inhibitors cyclosporine and tacrolimus are at high risk of developing renal injury .',
  'Acute kidney injury ( AKI ) is a serious clinical problem with high rate of mortality and morbidity .',
  'Epidemiological investigations have shown that CKD has become a serious global health problem .',
  'Rhabdomyolysis is a serious problem that must be recognized early to avoid grave renal consequences .',
  'Acute kidney injury ( AKI ) is a severe and preventable problem of crushed earthquake victims .',
  'A severe , chronic and irreversible kidney disease affecting discrete rural populations in the Balkan Peninsula countries , Balkan endemic nephropathy ( BEN ) has been a scientific puzzle for more than half a century .',
  'Renal disease becomes a serious problem for adults with TSC .',
  'Nephrotoxicity induced by antimicrobial or anticancer drugs is a serious clinical problem .',
  'Renal disease becomes a serious problem for adults with TSC .',
  'Data on the epidemiology of chronic kidney disease ( CKD ) , which is a serious health problem and refers to a condition related to irreversible kidney damage that further progress to end-stage renal disease in children , are insufficient and data that are available were based on hospital records .',
  'As about 50 % cases presented with varying degree of renal insufficiency , many ending with ESRD , IgA nephropathy can be considered as a serious problem in India .',
  'In Belgium , AN still remains a serious problem with a prevalence of 18 % in dialysis patients .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem throughout the world and is one of the most potent known risk factors for cardiovascular disease .',
  'Although fatigue among the dialysis population is known as a severe and debilitating health problem , this symptom is often under recognized and undertreated .',
  'Acute kidney injury is a serious public health problem , especially in intensive care units , where patients may require dialysis support , resulting in 50 % mortality .',
  'Chronic renal failure ( CRF ) represents a serious medical problem .',
  "Chronic kidney disease ( CKD ) is still a serious health problem in children with increasing morbidity and affecting children 's quality of life ( QoL ) .",
  'End-stage renal disease ( ESRD ) is a serious health problem worldwide .',
  'It accounts for 8 - 10 % of the cases of end-stage renal disease worldwide , thus representing a serious medical , economical and social problem .',
  'Chronic kidney disease poses a serious health problem worldwide with increasing prevalence and lack of effective treatment .',
  'Renal involvement can be a serious problem for patients with antiphospholipid syndrome ( APS ) .',
  'Chronic renal failure , particularly end-stage renal disease , is a serious health problem associated with a high mortality rate .',
  'Acute kidney injury following cardiac surgery depicts a severe clinical problem that is strongly associated with adverse short- and long-term outcome .',
  'Acute kidney injury ( AKI ) is a serious global public health problem .',
  'Chronic kidney disease has become a serious public health problem in China .',
  'Chronic kidney disease ( CKD ) represents a serious public health concern .',
  'In 2013 , the PAHO Member States recognized the epidemic of chronic kidney disease of non-traditional causes ( CKDnT ) as a serious public health problem .',
  'Cancer presents a growing trend , and chronic kidney disease emerges as a serious health problem .',
  'Cyclosporin A (CyA)-induced nephrotoxicity is still a serious clinical problem .',
  'End-stage renal disease ( ESRD ) is a serious public health problem .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem ; the number of people with impaired renal function is rapidly rising , especially in industrialized countries .',
  'Despite of unquestionable progress in heamodialysis treatment quite high morbidity and mortality still remain a serious problem among pediatric patients .',
  'The progression of chronic kidney disease is accompanied by multi-organ disorders , among which cardiovascular diseases have the status of a serious clinical problem .',
  'Chronic renal failure is a devastating medical , social , and economic problem for patients and their families in India and Pakistan .',
  'Terminal chronic kidney disease courses with high mortality and is a serious public health problem on a global scale .',
  'Steady increase in the prevalence of chronic kidney disease ( CKD ) is a serious public health problem , since CKD potentially leads to the development of end-stage renal disease ( ESRD ) that requires high-cost replacement therapy and is closely associated with increased risk of developing cardiovascular diseases ( CVD ) , which are the cause of death in most patients .',
  'The occurrence of non-function in one half of a horseshoe kidney resulting from hydronephrosis can , if unrecognized , create a serious surgical as well as medical problem .',
  'The nephrotoxicity of CYA , however , is a serious problem , and constitutes the major obstacle limiting the use of CYA as an immunosuppressive agent for renal transplantation .',
  'End-stage renal disease represents a serious public health problem in Jalisco , Mexico .',
  'Chronic kidney disease ( CKD ) is a serious medical problem and public health issue in Taiwan .',
  'Despite their low prevalence , genetic kidney diseases ( GKD ) still represent a serious health problem .',
  'Acute kidney injury ( AKI ) is a serious and common problem that is associated with high mortality .',
  'Acute renal failure ( ARF ) remains a serious medical problem with a high mortality rate .',
  'End-stage renal disease ( ESRD ) is a serious public health problem in Guangxi , a province of south China .',
  'There have been no opportunistic infections , aseptic necrosis or peptic ulcers in this group and cyclosporine nephrotoxicity has not been a serious problem in the pediatric recipients .',
  'Bone loss remains a serious problem after kidney transplantation and is most pronounced during the first months after engraftment .',
  'Acute kidney injury ( AKI ) constitutes a serious public health problem because of its very high cost and mortality rate , with an increasing incidence , phenomenon which is explained by the increasingly number of older patients suffering from several comorbidities admitted in the intensive care units .',
  'Renal failure after bypass is still a threatening problem prolonging hospital care and reducing overall survival .',
  'In fact , drug-induced kidney injury is a serious problem in clinical practice and accounts for roughly 20 % of cases of acute kidney injury ( AKI ) among hospitalized patients .',
  'Despite increased prevalence of renal insufficiency in CABG patients , studies show that in most cases , this is not a serious problem and it is easily treatable .',
  'Urological complications of kidney transplantation remain a serious postoperative problem .',
  'Acute kidney injury ( AKI ) is a serious problem .',
  'The number of patients with end-stage renal disease ( ESRD ) has been increasing , with dialysis treatment being a serious economic problem .',
  'CKD has become a severe public health problem in Zhejiang Province , and metabolic diseases may increase the risk of CKD in Zhejiang population .',
  'End-stage renal disease has steadily increased in prevalence and incidence ( 478.2 and 168.7 pmp , respectively ) and is emerging as a devastating medical , social , and economic problem for patients , families , and national health systems .',
  'These markers are also elevated in end-stage renal disease ( ESRD ) , which constitutes a serious public health problem .',
  'Moreover , the global prevalence of patients with chronic kidney disease is gradually increasing , which poses a serious public health problem .',
  'Delayed renal allograft function is a serious problem .',
  '[ Hemodialysis as a heavy burden on the health insurance system . A serious problem to smaller insurance groups ] .',
  'Renal insufficiency is a serious medical and public health problem worldwide .',
  'Protein-energy wasting ( PEW ) , a syndrome involving adverse changes in nutrition and body composition , is a serious problem associated with morbidity and mortality in patients with end-stage renal disease ( ESRD ) .',
  'Acute kidney injury ( AKI ) is a devastating clinical problem that affects a growing number of patients , especially elderly ones , and is associated with high morbidity and mortality .',
  'Chronic renal disease constitutes a serious worldwide clinical problem .',
  'Ureteral necrosis is a serious problem in kidney transplantation .',
  'Chronic kidney disease ( CKD ) is a serious public health problem in Taiwan and the world .',
  'Over the last 20 years , many reports have described an excess of cases of chronic kidney disease ( CKD ) in the Pacific coastal area of Central America , mainly affecting male farmworkers and signaling a serious public health problem .',
  'Although kidney transplantation was hailed as an optimal solution to such devastating disease , many issues related to immune-suppressive drugs soon emerged and it became evident that cardiovascular disease would remain a vexing problem .',
  'Chronic kidney disease ( CKD ) has become a serious public health problem because of its associated morbidity , premature mortality , and attendant healthcare costs .',
  'In critically ill patients , acute kidney injury ( AKI ) is a devastating problem often associated with adverse outcomes .',
  'Acute renal failure is a serious problem following heart transplantation .',
  'Latent chronic kidney disease ( CKD ) population appears to be a serious health problem in Japan .',
  'Acute Renal Failure ( ARF ) is the most costly kidney disease in hospitalized patients and remains as a serious problem in clinical medicine .',
  'Renal disease is a serious health problem , with increasing incidence and prevalence .',
  'Triage in civilian practice first became a serious issue with the development of dialysis for chronic renal failure in the 1960s and the problem of the allocation of this scarce and very expensive treatment .',
  'DN is a serious public health concern because it is the leading cause of end stage renal disease ( ESRD ) in most developed countries and is associated with increased cardiovascular mortality and morbidity .',
  'Chronic kidney disease ( CKD ) , defined as reduced glomerular filtration rate and/or proteinuria , is a serious worldwide health problem .',
  'The exponential increase in the number of patients on the renal transplant waiting list globally has become a serious problem fueled by an increase in the number of patients with end-stage renal disease , the shortage of organs for transplant , and the failure of transplanted kidneys for various reasons .',
  'Acute kidney injury following cardiac surgery is a serious problem among patients in eastern Saudi Arabia .',
  'Chronic kidney disease ( CKD ) poses a serious public health problem worldwide .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem ; the number of people with impaired renal function is rapidly rising .',
  'When progressing toward kidney failure , it is becoming a serious public health problem .',
  'Chronic renal failure is a serious health problem in the United States and other developed countries , and large amounts of public funds are being expended for what is essentially palliative treatment of this disease .',
  'Acute renal failure presents a serious and life-threatening problem in hospitalized patients .',
  'Uremia , the result of renal failure , is a serious clinical problem .',
  'The immunosuppressive drug tacrolimus ( FK506 ) is used clinically to reduce the rejection rate in patients with kidney transplantation ; however , the resultant nephrotoxicity remains a serious problem .',
  'In El Salvador , chronic kidney disease is a serious and growing public health problem .',
  'Chronic kidney disease is a serious health problem in El Salvador .',
  'Chronic lymphocytic leukemia ( CLL ) in association with glomerulonephritis ( GN ) and renal failure is a serious problem in terms of therapy .',
  'End stage renal disease patients is a serious problem all around the world .',
  'Chronic kidney disease ( CKD ) has emerged as a serious public health problem worldwide .',
  'Chronic kidney disease ( CKD ) represents a serious concern for the Mexican population since the main predisposing diseases ( diabetes , hypertension , etc . ) have a high prevalence in the country .',
  'Acute kidney injury remains a serious clinical problem for intensive care unit patients , and its incidence is rising .',
  'Chronic kidney disease ( CKD ) is considered a serious public health problem , both in Brazil and worldwide , with an increasing number of cases observed inrecent years .',
  'Acute kidney injury ( AKI ) remains a vexing clinical problem that results in unacceptably high patient mortality , development of chronic kidney disease , and accelerated progression to end-stage kidney disease .',
  'End stage renal disease ( ESRD ) is a devastating medical , social and economic problem in any community and needs dedicated supervision and health care .',
  'Chronic kidney disease ( CKD ) is a serious universal problem that is the main risk for several diseases including cardiovascular disease .',
  'Health professionals perceived CKD as a serious and increasing problem in the region , primarily affecting young men working as manual laborers .',
  'In transplant recipients , nephrotoxicity due to long-term use of calcineurin inhibitor ( CNI ) is a serious problem that can not be overlooked .',
  'In the recent times , Chronic Kidney Diseases ( CKDs ) are emerging as a serious problem all over the world along with diabetes mellitus and hypertension .',
  'Wasting of lean tissue as a consequence of metabolic acidosis is a serious problem in patients with chronic renal failure .',
  'Late presentation ( LP ) of chronic kidney disease ( CKD ) patients to nephrologist is a serious problem worldwide with persistent high prevalence despite known benefits of early nephrology care .',
  'However , the nephrotoxicity induced by FK506 remains a serious clinical problem .',
  'For renal transplant recipient treated with ICIs , the increased incidence of rejection is a serious concern .',
  'Renal failure after heart transplantation ( HTx ) still remains a serious problem , especially when cyclosporin A is used for immunosuppression in the early postoperative therapy .',
  'The nephrotoxicity induced by immunosuppressant FK506 remains a serious clinical problem , and the underlying mechanism has not been completely understood .',
  'End-stage renal disease represents a serious public health problem in Mexico .',
  'Chronic kidney disease ( CKD ) is a serious health problem with high morbidity and mortality , mainly attributable to cardiovascular risk .',
  'Hypercoagulability , a serious problem in patients with ESRD on maintenance hemodialysis , and its correction after kidney transplantation .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem throughout the world and is one of the most potent known risk factors for cardiovascular disease ( CVD ) which is considered the leading cause of morbidity and mortality in this cohort of patients .',
  'Allograft loss remains a severe clinical problem after kidney transplantation .',
  'Kidney disease is a serious problem that adversely affects human health , but critical knowledge is lacking on how to effectively treat established chronic kidney disease .',
  'In patients with autosomal dominant polycystic kidney disease ( ADPKD ) , massive renal enlargement is a serious problem .',
  'Epidemiological data show that chronic kidney disease ( CKD ) is a serious social problem and nowadays is included amongst civilisation diseases .',
  'The prevalence of end-stage renal disease is emerging as a serious worldwide public health problem because of the shortage of donor organs and the need to take lifelong immunosuppressive medication in patients who receive a transplanted kidney .',
  'PVAN was the leading cause of renal loss in SPK patients in the first 2 years after transplantation and is a serious concern for SPK recipients .',
  'End-stage renal disease ( ESRD ) is a severe health concern over the world .',
  'Cyclosporin has improved graft survival after renal transplantation , but cyclosporin nephrotoxicity is a severe clinical problem .',
  "Chronic kidney disease ( CKD ) is a serious public health problem and its prevalence is growing in many countries , often related to issues resulting from the lifestyle in growing economies and the population 's life expectancy .",
  'Nonadherence to different aspects of ESRD continues to be a serious problem among dialysis patients , and it is closely linked to depression and anxiety .',
  'the cost of chronic kidney disease requires a large amount of economic resources , and is becoming a serious problem for health services and families .',
  'Chronic kidney disease ( CKD ) represents a serious public health problem due to the increase in incidence and prevalence of this disease worldwide .',
  "Chronic renal failure is a severe clinical problem which has some significant socioeconomic impact worldwide and hemodialysis is an important way to maintain patients ' health state , but it seems difficult to get better in short time .",
  'Drug nephrotoxicity is a serious health and economic problem worldwide .',
  'The inclining incidence of chronic kidney disease which has led to high mortality and immense medical burden over the past decades has become a distressing concern in epidemiology .',
  'Chronic kidney disease ( CKD ) is a serious health problem worldwide .',
  'However , even the asymptomatic proteinuria , when profuse , may be a serious problem because it predisposes to arterial thromboembolism and eventually contributes to the deterioration of the body condition .',
  'Acute kidney injury ( AKI ) can be a devastating problem for hospitalized patients .',
  'Chronic kidney disease ( CKD ) is a severe health problem worldwide , and vascular calcification ( VC ) contributes substantially to the cardiovascular morbidity and high mortality of CKD .',
  'Acute kidney injury in the context of nephrotic syndrome is a serious and alarming clinical problem .',
  'Post-transplant renal osteopathy ( ROP ) remains a serious problem , which contributes to substantial long-term morbidity of the graft recipients .',
  'Acute kidney injury ( AKI ) is a serious problem occurring in anywhere between 8 and 30 % of children in the intensive care unit .',
  'Chronic kidney disease ( CKD ) is considered a serious worldwide public health problem , but data from developing countries are extremely limited .',
  'Acute tubular necrosis ( ATN ) represents a serious problem in kidney transplantation .'],
 'renal': ['Renal infarction is a rare and usually underdiagnosed entity',
  'Chronic kidney disease is a growing global health problem',
  'A major problem for patients with kidney disease is that most chronic renal diseases progress to endstage renal failure .',
  'The main problem with cyclosporine is that in many responders proteinuria relapses when the drug is stopped .',
  'The primary problem with eGFR is that the non-GFR determinants of serum creatinine and cystatin C , as well as their surrogates ( age , sex , and race ) , associate with CKD risk factors and outcomes .',
  'A major problem for patients with kidney disease and their physicians is that most chronic renal diseases progress to global glomerular sclerosis and end-stage renal failure .',
  'Cyclosporine A ( CsA ) is a potent immunosuppressant with the drawback of renal side effects .',
  'Micronutrient depletion is a major drawback of high-dose continuous renal replacement therapy ( CRRT ) .',
  'Cyclosporine A ( CsA ) is a potent immunosuppressant with the drawback of renal side-effects .',
  'Postischemic renal failure is a severe problem following cadaveric renal transplantation , especially if the kidney has been harvested from a non-heartbeating donor , and thereby subjected to periods of both warm and cold ischemia .',
  'Chronic kidney disease ( CKD ) is a serious public health problem .',
  'End-stage renal disease ( ESRD ) is a devastating medical , social , and economic problem .',
  'The prevalence of chronic kidney disease ( CKD ) as a serious public health problem is growing in the elderly .',
  'Although pediatric end-stage renal disease affects a small number of children , it is a serious and growing health problem in the United States .',
  'End-stage renal disease is a troublesome health problem worldwide .',
  'Kidney disease represents a serious global health problem .',
  'Reconstruction of the urinary tract because of ureteral stricture after kidney transplantation is a serious problem .',
  "Chronic kidney disease ( CKD ) is a serious health problem due to high mortality and morbidity , negative impact on the patients ' quality of life ( QOL ) , high diagnostic and therapeutic cost , and the burden on society .",
  'Chronic kidney disease ( CKD ) , impairment of kidney function , is a serious public health problem , and the assessment of genetic factors influencing kidney function has substantial clinical relevance .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem throughout the world and is one of the most potent known risk factors for cardiovascular disease , which is the leading cause of morbidity and mortality in this patient population .',
  'Clinical conference : a case of polycystic kidney , simulating a severe feeding problem .',
  'Malnutrition and loss of appetite represent a serious problem in children with chronic renal failure .',
  'Chronic renal failure ( CRF ) is a serious clinical problem and currently there are no adequate therapeutic strategies for treatment .',
  'While sirolimus ( SRL ) is thought to be a non-nephrotoxic agent , cyclosporine A ( CsA ) toxicity is a serious problem in kidney transplantation .',
  'Chronic kidney disease is a serious health problem caused by involvement of a large number of patients with kidney injury , especially in industrial countries .',
  'CIN is a serious clinical problem associated with increased morbidity and mortality , particularly in patients with chronic renal failure ( see the Case Report ) .',
  'Despite huge progress in transplantation , renal transplantation remains a serious problem since patients treated with the calcineurin inhibitors cyclosporine and tacrolimus are at high risk of developing renal injury .',
  'Epidemiological investigations have shown that CKD has become a serious global health problem .',
  'Rhabdomyolysis is a serious problem that must be recognized early to avoid grave renal consequences .',
  'A severe , chronic and irreversible kidney disease affecting discrete rural populations in the Balkan Peninsula countries , Balkan endemic nephropathy ( BEN ) has been a scientific puzzle for more than half a century .',
  'Renal disease becomes a serious problem for adults with TSC .',
  'Nephrotoxicity induced by antimicrobial or anticancer drugs is a serious clinical problem .',
  'Renal disease becomes a serious problem for adults with TSC .',
  'Data on the epidemiology of chronic kidney disease ( CKD ) , which is a serious health problem and refers to a condition related to irreversible kidney damage that further progress to end-stage renal disease in children , are insufficient and data that are available were based on hospital records .',
  'As about 50 % cases presented with varying degree of renal insufficiency , many ending with ESRD , IgA nephropathy can be considered as a serious problem in India .',
  'In Belgium , AN still remains a serious problem with a prevalence of 18 % in dialysis patients .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem throughout the world and is one of the most potent known risk factors for cardiovascular disease .',
  'Although fatigue among the dialysis population is known as a severe and debilitating health problem , this symptom is often under recognized and undertreated .',
  'Chronic renal failure ( CRF ) represents a serious medical problem .',
  "Chronic kidney disease ( CKD ) is still a serious health problem in children with increasing morbidity and affecting children 's quality of life ( QoL ) .",
  'End-stage renal disease ( ESRD ) is a serious health problem worldwide .',
  'It accounts for 8 - 10 % of the cases of end-stage renal disease worldwide , thus representing a serious medical , economical and social problem .',
  'Chronic kidney disease poses a serious health problem worldwide with increasing prevalence and lack of effective treatment .',
  'Chronic renal failure , particularly end-stage renal disease , is a serious health problem associated with a high mortality rate .',
  'Chronic kidney disease has become a serious public health problem in China .',
  'Chronic kidney disease ( CKD ) represents a serious public health concern .',
  'In 2013 , the PAHO Member States recognized the epidemic of chronic kidney disease of non-traditional causes ( CKDnT ) as a serious public health problem .',
  'Cancer presents a growing trend , and chronic kidney disease emerges as a serious health problem .',
  'Cyclosporin A (CyA)-induced nephrotoxicity is still a serious clinical problem .',
  'End-stage renal disease ( ESRD ) is a serious public health problem .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem ; the number of people with impaired renal function is rapidly rising , especially in industrialized countries .',
  'Despite of unquestionable progress in heamodialysis treatment quite high morbidity and mortality still remain a serious problem among pediatric patients .',
  'The progression of chronic kidney disease is accompanied by multi-organ disorders , among which cardiovascular diseases have the status of a serious clinical problem .',
  'Chronic renal failure is a devastating medical , social , and economic problem for patients and their families in India and Pakistan .',
  'Terminal chronic kidney disease courses with high mortality and is a serious public health problem on a global scale .',
  'Steady increase in the prevalence of chronic kidney disease ( CKD ) is a serious public health problem , since CKD potentially leads to the development of end-stage renal disease ( ESRD ) that requires high-cost replacement therapy and is closely associated with increased risk of developing cardiovascular diseases ( CVD ) , which are the cause of death in most patients .',
  'The nephrotoxicity of CYA , however , is a serious problem , and constitutes the major obstacle limiting the use of CYA as an immunosuppressive agent for renal transplantation .',
  'End-stage renal disease represents a serious public health problem in Jalisco , Mexico .',
  'Chronic kidney disease ( CKD ) is a serious medical problem and public health issue in Taiwan .',
  'Despite their low prevalence , genetic kidney diseases ( GKD ) still represent a serious health problem .',
  'End-stage renal disease ( ESRD ) is a serious public health problem in Guangxi , a province of south China .',
  'There have been no opportunistic infections , aseptic necrosis or peptic ulcers in this group and cyclosporine nephrotoxicity has not been a serious problem in the pediatric recipients .',
  'Bone loss remains a serious problem after kidney transplantation and is most pronounced during the first months after engraftment .',
  'Despite increased prevalence of renal insufficiency in CABG patients , studies show that in most cases , this is not a serious problem and it is easily treatable .',
  'Urological complications of kidney transplantation remain a serious postoperative problem .',
  'The number of patients with end-stage renal disease ( ESRD ) has been increasing , with dialysis treatment being a serious economic problem .',
  'CKD has become a severe public health problem in Zhejiang Province , and metabolic diseases may increase the risk of CKD in Zhejiang population .',
  'End-stage renal disease has steadily increased in prevalence and incidence ( 478.2 and 168.7 pmp , respectively ) and is emerging as a devastating medical , social , and economic problem for patients , families , and national health systems .',
  'These markers are also elevated in end-stage renal disease ( ESRD ) , which constitutes a serious public health problem .',
  'Moreover , the global prevalence of patients with chronic kidney disease is gradually increasing , which poses a serious public health problem .',
  'Delayed renal allograft function is a serious problem .',
  '[ Hemodialysis as a heavy burden on the health insurance system . A serious problem to smaller insurance groups ] .',
  'Renal insufficiency is a serious medical and public health problem worldwide .',
  'Protein-energy wasting ( PEW ) , a syndrome involving adverse changes in nutrition and body composition , is a serious problem associated with morbidity and mortality in patients with end-stage renal disease ( ESRD ) .',
  'Chronic renal disease constitutes a serious worldwide clinical problem .',
  'Ureteral necrosis is a serious problem in kidney transplantation .',
  'Chronic kidney disease ( CKD ) is a serious public health problem in Taiwan and the world .',
  'Over the last 20 years , many reports have described an excess of cases of chronic kidney disease ( CKD ) in the Pacific coastal area of Central America , mainly affecting male farmworkers and signaling a serious public health problem .',
  'Although kidney transplantation was hailed as an optimal solution to such devastating disease , many issues related to immune-suppressive drugs soon emerged and it became evident that cardiovascular disease would remain a vexing problem .',
  'Chronic kidney disease ( CKD ) has become a serious public health problem because of its associated morbidity , premature mortality , and attendant healthcare costs .',
  'Acute renal failure is a serious problem following heart transplantation .',
  'Latent chronic kidney disease ( CKD ) population appears to be a serious health problem in Japan .',
  'Renal disease is a serious health problem , with increasing incidence and prevalence .',
  'Triage in civilian practice first became a serious issue with the development of dialysis for chronic renal failure in the 1960s and the problem of the allocation of this scarce and very expensive treatment .',
  'DN is a serious public health concern because it is the leading cause of end stage renal disease ( ESRD ) in most developed countries and is associated with increased cardiovascular mortality and morbidity .',
  'Chronic kidney disease ( CKD ) , defined as reduced glomerular filtration rate and/or proteinuria , is a serious worldwide health problem .',
  'The exponential increase in the number of patients on the renal transplant waiting list globally has become a serious problem fueled by an increase in the number of patients with end-stage renal disease , the shortage of organs for transplant , and the failure of transplanted kidneys for various reasons .',
  'Chronic kidney disease ( CKD ) poses a serious public health problem worldwide .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem ; the number of people with impaired renal function is rapidly rising .',
  'When progressing toward kidney failure , it is becoming a serious public health problem .',
  'Chronic renal failure is a serious health problem in the United States and other developed countries , and large amounts of public funds are being expended for what is essentially palliative treatment of this disease .',
  'Uremia , the result of renal failure , is a serious clinical problem .',
  'The immunosuppressive drug tacrolimus ( FK506 ) is used clinically to reduce the rejection rate in patients with kidney transplantation ; however , the resultant nephrotoxicity remains a serious problem .',
  'In El Salvador , chronic kidney disease is a serious and growing public health problem .',
  'Chronic kidney disease is a serious health problem in El Salvador .',
  'Chronic lymphocytic leukemia ( CLL ) in association with glomerulonephritis ( GN ) and renal failure is a serious problem in terms of therapy .',
  'End stage renal disease patients is a serious problem all around the world .',
  'Chronic kidney disease ( CKD ) has emerged as a serious public health problem worldwide .',
  'Chronic kidney disease ( CKD ) represents a serious concern for the Mexican population since the main predisposing diseases ( diabetes , hypertension , etc . ) have a high prevalence in the country .',
  'Chronic kidney disease ( CKD ) is considered a serious public health problem , both in Brazil and worldwide , with an increasing number of cases observed inrecent years .',
  'End stage renal disease ( ESRD ) is a devastating medical , social and economic problem in any community and needs dedicated supervision and health care .',
  'Chronic kidney disease ( CKD ) is a serious universal problem that is the main risk for several diseases including cardiovascular disease .',
  'Health professionals perceived CKD as a serious and increasing problem in the region , primarily affecting young men working as manual laborers .',
  'In transplant recipients , nephrotoxicity due to long-term use of calcineurin inhibitor ( CNI ) is a serious problem that can not be overlooked .',
  'In the recent times , Chronic Kidney Diseases ( CKDs ) are emerging as a serious problem all over the world along with diabetes mellitus and hypertension .',
  'Wasting of lean tissue as a consequence of metabolic acidosis is a serious problem in patients with chronic renal failure .',
  'Late presentation ( LP ) of chronic kidney disease ( CKD ) patients to nephrologist is a serious problem worldwide with persistent high prevalence despite known benefits of early nephrology care .',
  'However , the nephrotoxicity induced by FK506 remains a serious clinical problem .',
  'For renal transplant recipient treated with ICIs , the increased incidence of rejection is a serious concern .',
  'Renal failure after heart transplantation ( HTx ) still remains a serious problem , especially when cyclosporin A is used for immunosuppression in the early postoperative therapy .',
  'The nephrotoxicity induced by immunosuppressant FK506 remains a serious clinical problem , and the underlying mechanism has not been completely understood .',
  'End-stage renal disease represents a serious public health problem in Mexico .',
  'Chronic kidney disease ( CKD ) is a serious health problem with high morbidity and mortality , mainly attributable to cardiovascular risk .',
  'Hypercoagulability , a serious problem in patients with ESRD on maintenance hemodialysis , and its correction after kidney transplantation .',
  'Chronic kidney disease ( CKD ) is becoming a serious health problem throughout the world and is one of the most potent known risk factors for cardiovascular disease ( CVD ) which is considered the leading cause of morbidity and mortality in this cohort of patients .',
  'Allograft loss remains a severe clinical problem after kidney transplantation .',
  'Kidney disease is a serious problem that adversely affects human health , but critical knowledge is lacking on how to effectively treat established chronic kidney disease .',
  'In patients with autosomal dominant polycystic kidney disease ( ADPKD ) , massive renal enlargement is a serious problem .',
  'Epidemiological data show that chronic kidney disease ( CKD ) is a serious social problem and nowadays is included amongst civilisation diseases .',
  'The prevalence of end-stage renal disease is emerging as a serious worldwide public health problem because of the shortage of donor organs and the need to take lifelong immunosuppressive medication in patients who receive a transplanted kidney .',
  'PVAN was the leading cause of renal loss in SPK patients in the first 2 years after transplantation and is a serious concern for SPK recipients .',
  'End-stage renal disease ( ESRD ) is a severe health concern over the world .',
  'Cyclosporin has improved graft survival after renal transplantation , but cyclosporin nephrotoxicity is a severe clinical problem .',
  "Chronic kidney disease ( CKD ) is a serious public health problem and its prevalence is growing in many countries , often related to issues resulting from the lifestyle in growing economies and the population 's life expectancy .",
  'Nonadherence to different aspects of ESRD continues to be a serious problem among dialysis patients , and it is closely linked to depression and anxiety .',
  'the cost of chronic kidney disease requires a large amount of economic resources , and is becoming a serious problem for health services and families .',
  'Chronic kidney disease ( CKD ) represents a serious public health problem due to the increase in incidence and prevalence of this disease worldwide .',
  "Chronic renal failure is a severe clinical problem which has some significant socioeconomic impact worldwide and hemodialysis is an important way to maintain patients ' health state , but it seems difficult to get better in short time .",
  'Drug nephrotoxicity is a serious health and economic problem worldwide .',
  'The inclining incidence of chronic kidney disease which has led to high mortality and immense medical burden over the past decades has become a distressing concern in epidemiology .',
  'Chronic kidney disease ( CKD ) is a serious health problem worldwide .',
  'However , even the asymptomatic proteinuria , when profuse , may be a serious problem because it predisposes to arterial thromboembolism and eventually contributes to the deterioration of the body condition .',
  'Chronic kidney disease ( CKD ) is a severe health problem worldwide , and vascular calcification ( VC ) contributes substantially to the cardiovascular morbidity and high mortality of CKD .',
  'Post-transplant renal osteopathy ( ROP ) remains a serious problem , which contributes to substantial long-term morbidity of the graft recipients .',
  'Chronic kidney disease ( CKD ) is considered a serious worldwide public health problem , but data from developing countries are extremely limited .',
  'Acute tubular necrosis ( ATN ) represents a serious problem in kidney transplantation .'],
 'falls': ['Imbalance in elderly is a common problem strictly related to fall',
  "However , a drawback of these approaches is that they rely on falls simulated by young or mature people , which might not represent every possible fall situation and might be different from older people 's falls .",
  'Slips and falls are a serious public health concern in older populations .',
  'Falls are a serious concern for older adults as they frequently result in injury , disability and even death .',
  'Falls during stair descent are a serious problem and can lead to accidental death .',
  'Falling is a serious problem in an aged society such that assessment of the risk of falls for individuals is imperative for the research and practice of falls prevention .',
  "During interventions , patients ' accidental falls from the bed are a serious problem , and spe-cialized fixation systems for hemodialysis patients to prevent their falls from the bed have been lacking .",
  'Falls pose a serious problem in elderly and clinical populations .',
  'Falls are a serious problem for hospitalized patients , reducing the duration and quality of life .',
  'Falls are a serious health problem for aged people , causing social and economic burden .',
  'Tripping and falling is a serious health problem for older citizens due to the high medical costs incurred and the high mortality rates precipitated mostly by hip fractures that do not heal well .',
  'Fear of falling ( FF ) is a serious problem in elderly .',
  'Falls are a serious and preventable problem in older adults .',
  'Disequilibrium and gait disturbance are the most common causes of falls , which are becoming a serious social problem for the increasing geriatric population .',
  'Falls are a serious problem among older cancer patients .',
  'Falls are a serious public health concern among older adults in the United States .',
  'Fall events and their severe consequences represent not only a threatening problem for the affected individual , but also cause a significant burden for health care systems .',
  'Patient falls are a serious problem in hospitals , resulting in substantial morbidity , mortality , length of stay , and costs .',
  'Falls are a serious , persistent problem in hospitals .',
  'Falling is a serious health problem for many elderly .',
  'Falls are a serious health concern for older people and an important issue for nurses .',
  'Falls in older adults are a serious problem for individuals , their families , and the health care system .',
  'Falls due to slipping are a serious concern , with slipping estimated to cause 40 - 50 % of all fall-related injuries .',
  'Accidental fall is a serious problem in older adults .',
  'Falls are a globally common , important , and a preventable problem .',
  'For older adults , falls are a serious health problem , with more than 30 % of people older than 65 suffering a fall at least once a year .',
  'Falls are a serious problem among stroke survivors due to subsequent injuries , recovery setbacks , dependence , and mortality .',
  'Falls are a serious health problem in old adults especially in nursing home residents and hospitalized patients .',
  'Fall-related injuries are a serious health problem associated with dependency and disability in the elderly and results in high costs to public health systems .',
  'Falls in the elderly have become a serious social problem worldwide .',
  'Falls are a serious health problem in older adults .',
  'For elderly osteoporotic people falls are a serious problem .',
  'Falling in older age is a serious and costly problem .',
  'Falls and fall-related injuries are a serious health concern in geriatric populations , especially with age-related deficits in postural control and during postural control challenging dual-task situations .',
  "Falls are a debilitating problem for people with Parkinson 's disease ( PD ) .",
  'Fall-induced injuries and resulting deaths are a serious health problem among older adults .',
  'Dizziness in the elderly is a serious health concern due to the increased morbidity caused by falling .',
  '\u2002  Falls are a serious problem in older patients .',
  'This study demonstrates that falls are a serious safety concern in the workplace .',
  'Falls are a serious problem for older adults .',
  'Among medical accidents , accidental falls remain a serious problem .',
  'Falls among older adults with intellectual disability ( ID ) are recognised as a serious health problem potentially resulting in reduced health-related quality of life and premature placement in residential care .',
  'Falls in older adults are a serious public health concern .',
  'Falls in older adults continues to be a serious problem worldwide .',
  'Patient falls in hospitals are a serious problem and can cause long delays in their recovery .',
  "Many older persons interviewed did not perceive falls as a serious problem , some reported a stigma surrounding falls , while others felt they had not sustained more serious injuries due to God 's grace .",
  'Patient falls constitute a serious problem both for the persons fallen and for the institutions involved .',
  'Those who work with institutionalized elderly have been much more aware of falls as a serious problem .',
  'The high frequency of fall accidents is a serious problem in Japan .',
  'Falls are a serious problem for the elderly and others prone to fall .',
  'Falls are a serious health and medical concern facing older adults worldwide .',
  'Falls are a serious health problem in the aging population .',
  'Falls are a serious public health problem and one of the most important concerns for older people .',
  'Falls from height , particularly from roofs in Diyarbakir , remain a serious problem in terms of public health .',
  'Falls represent a serious problem in older inpatients due to the potential physical , social , psychological and economic consequences .',
  'Fall risk is a serious problem especially for the elderly .',
  'Falls are a serious health problem for older adults .',
  'Falling is a serious problem for the elderly which consequences -- fractures , other lesions and the fear of falling -- may result in auto-restrictions in daily living activities , producing immobility and accelerating the physical decline associated with aging .',
  'Falls represent a serious problem facing hospital-admitted patients , and the severity of fall-related complications rises steadily after the age of 65 years .',
  'Slips and falls represent a serious public safety concern in older adults , with the segment of the United States population over the age of 65 accounting for about three quarters of all fall related deaths .',
  'Falls are a serious public health problem and possibly life threatening for people in fall risk groups .',
  'Because falls and impairments in mobility remain a serious problem among elderly people , alternative strategies should be developed and evaluated .',
  'Dizziness is a common medical condition that has been related to falls in the elderly , and it is , therefore , considered a severe social health problem .',
  'Falls among older people constitute a serious public health problem , which has a substantial impact on both the person and on healthcare services .',
  'Patient falls in hospitals continue to exist as a serious societal problem .',
  'Inpatient falls , many resulting in injury or death , are a serious problem in hospital settings .',
  'Falls are a serious concern for wheelchair and scooter users with multiple sclerosis ( MS ) .',
  'Falls are a serious health concern for older adults .',
  'Although falls is a serious problem among elderly with many consequences , it has many preventable risk factors .',
  'It is also acknowledged that older people are at a greater risk of falls that are a devastating problem causing a tremendous amount of morbidity , mortality and use of health care services ( Rubestein , Age and Ageing , 35 , 2006 , 37 ) .',
  'Falls are a serious problem faced by the elderly .',
  'Fall-related injuries associated with aging are a serious clinical and economic problem .',
  'Falls precipitated by slipping are a serious public health concern especially in the elderly .',
  'Falling is a serious medical problem for elderly persons .',
  'Falls are a serious problem facing the elderly .',
  'There is a high incidence of seeking out care in urgent care centers due to falls , which constitutes a severe public health problem that affects both genders in different age groups .',
  'Falls among community-dwelling older adults are a serious public health concern .',
  'Patient fall has been a severe problem in healthcare facilities around the world due to its prevalence and cost .',
  'These findings suggest that fall-related injuries can be a serious health problem for vigorous as well as frail elderly persons .'],
 'fall': ['Imbalance in elderly is a common problem strictly related to fall',
  "However , a drawback of these approaches is that they rely on falls simulated by young or mature people , which might not represent every possible fall situation and might be different from older people 's falls .",
  'Slips and falls are a serious public health concern in older populations .',
  'Falls are a serious concern for older adults as they frequently result in injury , disability and even death .',
  'Falls during stair descent are a serious problem and can lead to accidental death .',
  'Falling is a serious problem in an aged society such that assessment of the risk of falls for individuals is imperative for the research and practice of falls prevention .',
  "During interventions , patients ' accidental falls from the bed are a serious problem , and spe-cialized fixation systems for hemodialysis patients to prevent their falls from the bed have been lacking .",
  'Falls pose a serious problem in elderly and clinical populations .',
  'Falls are a serious problem for hospitalized patients , reducing the duration and quality of life .',
  'Falls are a serious health problem for aged people , causing social and economic burden .',
  'Tripping and falling is a serious health problem for older citizens due to the high medical costs incurred and the high mortality rates precipitated mostly by hip fractures that do not heal well .',
  'Fear of falling ( FF ) is a serious problem in elderly .',
  'Falls are a serious and preventable problem in older adults .',
  'Disequilibrium and gait disturbance are the most common causes of falls , which are becoming a serious social problem for the increasing geriatric population .',
  'Falls are a serious problem among older cancer patients .',
  'Falls are a serious public health concern among older adults in the United States .',
  'Fall events and their severe consequences represent not only a threatening problem for the affected individual , but also cause a significant burden for health care systems .',
  'Patient falls are a serious problem in hospitals , resulting in substantial morbidity , mortality , length of stay , and costs .',
  'Falls are a serious , persistent problem in hospitals .',
  'Falling is a serious health problem for many elderly .',
  'Falls are a serious health concern for older people and an important issue for nurses .',
  'Falls in older adults are a serious problem for individuals , their families , and the health care system .',
  'Falls due to slipping are a serious concern , with slipping estimated to cause 40 - 50 % of all fall-related injuries .',
  'Accidental fall is a serious problem in older adults .',
  'Falls are a globally common , important , and a preventable problem .',
  'For older adults , falls are a serious health problem , with more than 30 % of people older than 65 suffering a fall at least once a year .',
  'Falls are a serious problem among stroke survivors due to subsequent injuries , recovery setbacks , dependence , and mortality .',
  'Falls are a serious health problem in old adults especially in nursing home residents and hospitalized patients .',
  'Fall-related injuries are a serious health problem associated with dependency and disability in the elderly and results in high costs to public health systems .',
  'Falls in the elderly have become a serious social problem worldwide .',
  'Falls are a serious health problem in older adults .',
  'For elderly osteoporotic people falls are a serious problem .',
  'Falling in older age is a serious and costly problem .',
  'Falls and fall-related injuries are a serious health concern in geriatric populations , especially with age-related deficits in postural control and during postural control challenging dual-task situations .',
  "Falls are a debilitating problem for people with Parkinson 's disease ( PD ) .",
  'Fall-induced injuries and resulting deaths are a serious health problem among older adults .',
  'Dizziness in the elderly is a serious health concern due to the increased morbidity caused by falling .',
  '\u2002  Falls are a serious problem in older patients .',
  'This study demonstrates that falls are a serious safety concern in the workplace .',
  'Falls are a serious problem for older adults .',
  'Among medical accidents , accidental falls remain a serious problem .',
  'Falls among older adults with intellectual disability ( ID ) are recognised as a serious health problem potentially resulting in reduced health-related quality of life and premature placement in residential care .',
  'Falls in older adults are a serious public health concern .',
  'Falls in older adults continues to be a serious problem worldwide .',
  'Patient falls in hospitals are a serious problem and can cause long delays in their recovery .',
  "Many older persons interviewed did not perceive falls as a serious problem , some reported a stigma surrounding falls , while others felt they had not sustained more serious injuries due to God 's grace .",
  'Patient falls constitute a serious problem both for the persons fallen and for the institutions involved .',
  'Those who work with institutionalized elderly have been much more aware of falls as a serious problem .',
  'The high frequency of fall accidents is a serious problem in Japan .',
  'Falls are a serious problem for the elderly and others prone to fall .',
  'Falls are a serious health and medical concern facing older adults worldwide .',
  'Falls are a serious health problem in the aging population .',
  'Falls are a serious public health problem and one of the most important concerns for older people .',
  'Falls from height , particularly from roofs in Diyarbakir , remain a serious problem in terms of public health .',
  'Falls represent a serious problem in older inpatients due to the potential physical , social , psychological and economic consequences .',
  'Fall risk is a serious problem especially for the elderly .',
  'Falls are a serious health problem for older adults .',
  'Falling is a serious problem for the elderly which consequences -- fractures , other lesions and the fear of falling -- may result in auto-restrictions in daily living activities , producing immobility and accelerating the physical decline associated with aging .',
  'Falls represent a serious problem facing hospital-admitted patients , and the severity of fall-related complications rises steadily after the age of 65 years .',
  'Slips and falls represent a serious public safety concern in older adults , with the segment of the United States population over the age of 65 accounting for about three quarters of all fall related deaths .',
  'Falls are a serious public health problem and possibly life threatening for people in fall risk groups .',
  'Because falls and impairments in mobility remain a serious problem among elderly people , alternative strategies should be developed and evaluated .',
  'Dizziness is a common medical condition that has been related to falls in the elderly , and it is , therefore , considered a severe social health problem .',
  'Falls among older people constitute a serious public health problem , which has a substantial impact on both the person and on healthcare services .',
  'Patient falls in hospitals continue to exist as a serious societal problem .',
  'Inpatient falls , many resulting in injury or death , are a serious problem in hospital settings .',
  'Falls are a serious concern for wheelchair and scooter users with multiple sclerosis ( MS ) .',
  'Falls are a serious health concern for older adults .',
  'Although falls is a serious problem among elderly with many consequences , it has many preventable risk factors .',
  'It is also acknowledged that older people are at a greater risk of falls that are a devastating problem causing a tremendous amount of morbidity , mortality and use of health care services ( Rubestein , Age and Ageing , 35 , 2006 , 37 ) .',
  'Falls are a serious problem faced by the elderly .',
  'Fall-related injuries associated with aging are a serious clinical and economic problem .',
  'Falls precipitated by slipping are a serious public health concern especially in the elderly .',
  'Falling is a serious medical problem for elderly persons .',
  'Falls are a serious problem facing the elderly .',
  'There is a high incidence of seeking out care in urgent care centers due to falls , which constitutes a severe public health problem that affects both genders in different age groups .',
  'Falls among community-dwelling older adults are a serious public health concern .',
  'Patient fall has been a severe problem in healthcare facilities around the world due to its prevalence and cost .',
  'These findings suggest that fall-related injuries can be a serious health problem for vigorous as well as frail elderly persons .'],
 'falling': ['Imbalance in elderly is a common problem strictly related to fall',
  "However , a drawback of these approaches is that they rely on falls simulated by young or mature people , which might not represent every possible fall situation and might be different from older people 's falls .",
  'Slips and falls are a serious public health concern in older populations .',
  'Falls are a serious concern for older adults as they frequently result in injury , disability and even death .',
  'Falls during stair descent are a serious problem and can lead to accidental death .',
  'Falling is a serious problem in an aged society such that assessment of the risk of falls for individuals is imperative for the research and practice of falls prevention .',
  'Falls pose a serious problem in elderly and clinical populations .',
  'Falls are a serious health problem for aged people , causing social and economic burden .',
  'Tripping and falling is a serious health problem for older citizens due to the high medical costs incurred and the high mortality rates precipitated mostly by hip fractures that do not heal well .',
  'Fear of falling ( FF ) is a serious problem in elderly .',
  'Falls are a serious and preventable problem in older adults .',
  'Disequilibrium and gait disturbance are the most common causes of falls , which are becoming a serious social problem for the increasing geriatric population .',
  'Falls are a serious problem among older cancer patients .',
  'Falls are a serious public health concern among older adults in the United States .',
  'Falling is a serious health problem for many elderly .',
  'Falls are a serious health concern for older people and an important issue for nurses .',
  'Falls in older adults are a serious problem for individuals , their families , and the health care system .',
  'Falls due to slipping are a serious concern , with slipping estimated to cause 40 - 50 % of all fall-related injuries .',
  'Accidental fall is a serious problem in older adults .',
  'For older adults , falls are a serious health problem , with more than 30 % of people older than 65 suffering a fall at least once a year .',
  'Falls are a serious problem among stroke survivors due to subsequent injuries , recovery setbacks , dependence , and mortality .',
  'Falls are a serious health problem in old adults especially in nursing home residents and hospitalized patients .',
  'Fall-related injuries are a serious health problem associated with dependency and disability in the elderly and results in high costs to public health systems .',
  'Falls in the elderly have become a serious social problem worldwide .',
  'Falls are a serious health problem in older adults .',
  'For elderly osteoporotic people falls are a serious problem .',
  'Falling in older age is a serious and costly problem .',
  'Falls and fall-related injuries are a serious health concern in geriatric populations , especially with age-related deficits in postural control and during postural control challenging dual-task situations .',
  "Falls are a debilitating problem for people with Parkinson 's disease ( PD ) .",
  'Fall-induced injuries and resulting deaths are a serious health problem among older adults .',
  'Dizziness in the elderly is a serious health concern due to the increased morbidity caused by falling .',
  '\u2002  Falls are a serious problem in older patients .',
  'Falls are a serious problem for older adults .',
  'Falls among older adults with intellectual disability ( ID ) are recognised as a serious health problem potentially resulting in reduced health-related quality of life and premature placement in residential care .',
  'Falls in older adults are a serious public health concern .',
  'Falls in older adults continues to be a serious problem worldwide .',
  "Many older persons interviewed did not perceive falls as a serious problem , some reported a stigma surrounding falls , while others felt they had not sustained more serious injuries due to God 's grace .",
  'Those who work with institutionalized elderly have been much more aware of falls as a serious problem .',
  'Falls are a serious problem for the elderly and others prone to fall .',
  'Falls are a serious health and medical concern facing older adults worldwide .',
  'Falls are a serious health problem in the aging population .',
  'Falls are a serious public health problem and one of the most important concerns for older people .',
  'Falls represent a serious problem in older inpatients due to the potential physical , social , psychological and economic consequences .',
  'Fall risk is a serious problem especially for the elderly .',
  'Falls are a serious health problem for older adults .',
  'Falling is a serious problem for the elderly which consequences -- fractures , other lesions and the fear of falling -- may result in auto-restrictions in daily living activities , producing immobility and accelerating the physical decline associated with aging .',
  'Falls represent a serious problem facing hospital-admitted patients , and the severity of fall-related complications rises steadily after the age of 65 years .',
  'Slips and falls represent a serious public safety concern in older adults , with the segment of the United States population over the age of 65 accounting for about three quarters of all fall related deaths .',
  'Because falls and impairments in mobility remain a serious problem among elderly people , alternative strategies should be developed and evaluated .',
  'Dizziness is a common medical condition that has been related to falls in the elderly , and it is , therefore , considered a severe social health problem .',
  'Falls among older people constitute a serious public health problem , which has a substantial impact on both the person and on healthcare services .',
  'Falls are a serious concern for wheelchair and scooter users with multiple sclerosis ( MS ) .',
  'Falls are a serious health concern for older adults .',
  'Although falls is a serious problem among elderly with many consequences , it has many preventable risk factors .',
  'It is also acknowledged that older people are at a greater risk of falls that are a devastating problem causing a tremendous amount of morbidity , mortality and use of health care services ( Rubestein , Age and Ageing , 35 , 2006 , 37 ) .',
  'Falls are a serious problem faced by the elderly .',
  'Fall-related injuries associated with aging are a serious clinical and economic problem .',
  'Falls precipitated by slipping are a serious public health concern especially in the elderly .',
  'Falling is a serious medical problem for elderly persons .',
  'Falls are a serious problem facing the elderly .',
  'There is a high incidence of seeking out care in urgent care centers due to falls , which constitutes a severe public health problem that affects both genders in different age groups .',
  'Falls among community-dwelling older adults are a serious public health concern .',
  'These findings suggest that fall-related injuries can be a serious health problem for vigorous as well as frail elderly persons .'],
 'abortion': ['Threatened abortion (TA) is the most common complication during early pregnancy affecting 20%-25% pregnancies',
  'The problem with analyzing decidual tissues from spontaneous abortions is that cause versus effect phenomena are difficult to distinguish .',
  'Abortion is a serious health problem in Brazil and complications can be avoided by adequate and timely care .',
  'It is now more than 50 years since the World Health Assembly recognized abortion as a serious public health problem .',
  'A majority of the health providers ( 96.4 % ) recognized that unsafe abortion was a serious health problem .',
  'Rejection episodes were occasionally a serious problem , occurring in 9 % of the pregnancies .',
  '" Brazil is the world champion of caesareans . " This prowess points out a serious public health problem . While the increase in the percentage of caesareans among all deliveries is an international phenomenon , it is highest by far in Brazil , where caesareans account for nearly 40 % of births , that is , three times the maximum recommended by WHO .',
  'Maternal mortality from complications of unsafe abortion constitutes a serious problem in several developing countries .',
  'Clandestine abortion is a serious public health problem in Brazil , and the inadequacy of family planning services is one of the causes of this problem .',
  'Most participants agreed that unsafe abortion is a serious health problem in India .',
  'The recurrent abortion syndrome has been considered a serious obstetrical problem , since it was not possible to diagnose the causes in over 40 % of the cases .',
  'Recurrent pregnancy loss is a devastating health problem that affects many couples who are trying to establish a family .',
  'Recurrent miscarriage is a serious clinical problem that affects 1 - 5 % of all couples trying to conceive .',
  'Recurrent pregnancy loss ( RPL ) is a serious problem for pregnancy .',
  'Recurrent spontaneous abortion ( RSA ) is a serious problem in pregnancy .',
  'Recurrent pregnancy loss ( RPL ) is a devastating reproductive problem affecting approximately 5 % of couples trying to conceive .',
  'Unsafe abortion remains a serious concern to the health of women .',
  'Recurrent pregnancy loss ( RPL ) is a serious problem in the reproductive age women .',
  'Misuse of abortion pill by unauthorized persons is a serious concern in India .',
  'In conclusion , the morbidity of abortion is a serious public health problem in Egypt .',
  'Recurrent pregnancy loss is a vexing problem facing many couples .',
  'In Brazil , the subject of induced abortion is controversial and considered by some to be a serious public health problem .',
  'Unsafe abortions are a serious public health problem and a major human rights issue .',
  'As evidenced by the high morbidity and mortality , abortions are a serious public health problem in rural Matebeleland North .',
  'Misoprostol is a pharmaceutical synthetic compound , analog of prostaglandin E1 , frequently used as an abortifacient in not medically supervised or self-induced abortions , particularly in countries with restrictive abortion laws representing a serious public health problem .',
  'However , clandestine abortion remains a serious health problem in Bangladesh , and anecdotal reports indicate that clandestine use of misoprostol has increased since the most recent estimates ( for 2010 ) .',
  'About 12 percent of respondents were hospitalized with complications from abortion , signifying a serious public health problem .',
  '[ Is abortion a serious public health problem in Chile in the field of maternal-perinatal health ? ]',
  'Recurrent pregnancy loss is a vexing problem facing many couples and doctors .'],
 'clandestine': ['Threatened abortion (TA) is the most common complication during early pregnancy affecting 20%-25% pregnancies',
  'Abortion is a serious health problem in Brazil and complications can be avoided by adequate and timely care .',
  'It is now more than 50 years since the World Health Assembly recognized abortion as a serious public health problem .',
  'A majority of the health providers ( 96.4 % ) recognized that unsafe abortion was a serious health problem .',
  'Maternal mortality from complications of unsafe abortion constitutes a serious problem in several developing countries .',
  'Clandestine abortion is a serious public health problem in Brazil , and the inadequacy of family planning services is one of the causes of this problem .',
  'Most participants agreed that unsafe abortion is a serious health problem in India .',
  'Unsafe abortion remains a serious concern to the health of women .',
  'Misuse of abortion pill by unauthorized persons is a serious concern in India .',
  'In conclusion , the morbidity of abortion is a serious public health problem in Egypt .',
  'In Brazil , the subject of induced abortion is controversial and considered by some to be a serious public health problem .',
  'Unsafe abortions are a serious public health problem and a major human rights issue .',
  'As evidenced by the high morbidity and mortality , abortions are a serious public health problem in rural Matebeleland North .',
  'Misoprostol is a pharmaceutical synthetic compound , analog of prostaglandin E1 , frequently used as an abortifacient in not medically supervised or self-induced abortions , particularly in countries with restrictive abortion laws representing a serious public health problem .',
  'However , clandestine abortion remains a serious health problem in Bangladesh , and anecdotal reports indicate that clandestine use of misoprostol has increased since the most recent estimates ( for 2010 ) .',
  'About 12 percent of respondents were hospitalized with complications from abortion , signifying a serious public health problem .',
  '[ Is abortion a serious public health problem in Chile in the field of maternal-perinatal health ? ]'],
 'abortions': ['Threatened abortion (TA) is the most common complication during early pregnancy affecting 20%-25% pregnancies',
  'Abortion is a serious health problem in Brazil and complications can be avoided by adequate and timely care .',
  'It is now more than 50 years since the World Health Assembly recognized abortion as a serious public health problem .',
  'A majority of the health providers ( 96.4 % ) recognized that unsafe abortion was a serious health problem .',
  'Maternal mortality from complications of unsafe abortion constitutes a serious problem in several developing countries .',
  'Clandestine abortion is a serious public health problem in Brazil , and the inadequacy of family planning services is one of the causes of this problem .',
  'Most participants agreed that unsafe abortion is a serious health problem in India .',
  'Unsafe abortion remains a serious concern to the health of women .',
  'Misuse of abortion pill by unauthorized persons is a serious concern in India .',
  'In conclusion , the morbidity of abortion is a serious public health problem in Egypt .',
  'In Brazil , the subject of induced abortion is controversial and considered by some to be a serious public health problem .',
  'Unsafe abortions are a serious public health problem and a major human rights issue .',
  'As evidenced by the high morbidity and mortality , abortions are a serious public health problem in rural Matebeleland North .',
  'Misoprostol is a pharmaceutical synthetic compound , analog of prostaglandin E1 , frequently used as an abortifacient in not medically supervised or self-induced abortions , particularly in countries with restrictive abortion laws representing a serious public health problem .',
  'However , clandestine abortion remains a serious health problem in Bangladesh , and anecdotal reports indicate that clandestine use of misoprostol has increased since the most recent estimates ( for 2010 ) .',
  'About 12 percent of respondents were hospitalized with complications from abortion , signifying a serious public health problem .',
  '[ Is abortion a serious public health problem in Chile in the field of maternal-perinatal health ? ]'],
 'misoprostol': ['Threatened abortion (TA) is the most common complication during early pregnancy affecting 20%-25% pregnancies',
  'Abortion is a serious health problem in Brazil and complications can be avoided by adequate and timely care .',
  'It is now more than 50 years since the World Health Assembly recognized abortion as a serious public health problem .',
  'A majority of the health providers ( 96.4 % ) recognized that unsafe abortion was a serious health problem .',
  'Maternal mortality from complications of unsafe abortion constitutes a serious problem in several developing countries .',
  'Clandestine abortion is a serious public health problem in Brazil , and the inadequacy of family planning services is one of the causes of this problem .',
  'Most participants agreed that unsafe abortion is a serious health problem in India .',
  'Unsafe abortion remains a serious concern to the health of women .',
  'Misuse of abortion pill by unauthorized persons is a serious concern in India .',
  'In conclusion , the morbidity of abortion is a serious public health problem in Egypt .',
  'In Brazil , the subject of induced abortion is controversial and considered by some to be a serious public health problem .',
  'Unsafe abortions are a serious public health problem and a major human rights issue .',
  'As evidenced by the high morbidity and mortality , abortions are a serious public health problem in rural Matebeleland North .',
  'Misoprostol is a pharmaceutical synthetic compound , analog of prostaglandin E1 , frequently used as an abortifacient in not medically supervised or self-induced abortions , particularly in countries with restrictive abortion laws representing a serious public health problem .',
  'However , clandestine abortion remains a serious health problem in Bangladesh , and anecdotal reports indicate that clandestine use of misoprostol has increased since the most recent estimates ( for 2010 ) .',
  'About 12 percent of respondents were hospitalized with complications from abortion , signifying a serious public health problem .',
  '[ Is abortion a serious public health problem in Chile in the field of maternal-perinatal health ? ]'],
 'hydatid': ['Paraurethral cyst is a rare cause of interlabial mass in neonates with an incidence of 1 in every 2000-7000 live births and represents less than 0',
  'Hydatidosis constitutes a serious Public Health problem in the Province of Rio Negro , Argentine .',
  'Recurrence of hydatid cysts in cystectomy patients has dramatically remained a serious concern within the surgical community .',
  'Hydatid liver disease in children is a serious problem where the parasite is endemic .',
  'Hydatic disease has always been the most common in countries where large amount of sheep and cattle is raised , but increased travel and immigration have made this condition a serious worldwide public problem .',
  'Human hydatid cyst or cystic echinococcosis is a life-threatening zoonotic disease that occurs in most countries worldwide and is recognized as a major public health problem .',
  'Hydatid disease is a serious public health problem in endemic areas , and the management is controversial .',
  'Hydatic cyst of the liver remains a serious public health problem in Morocco and several other Mediterranean countries .',
  'Hydatid disease is a serious public health problem in developing countries .',
  'Hydatid disease in childhood is a serious health problem in Turkey and other places where the parasite is endemic .',
  'The study indicates that in Turkey hydatidosis remains a serious problem , causing blindness .',
  'Hydatid cysts are a serious health problem in many countries that raise farm animals , and they usually involve the liver and lungs .',
  'Nevertheless , hydatic disease is a serious public health problem in endemic areas .',
  'In Turkey , spinal hydatidosis remains a serious health problem that is associated with high morbidity and mortality .',
  'Hydatid illness still presents a serious surgical problem and in the case of obstrukioni ikterus an operation is indispensable method in the treatment of illness .',
  'Liver hydatid cyst with cystobiliary communication and superadded acute cholangitis is a serious clinical problem requiring the early diagnosis and surgery in the absence of endoscopic therapy .',
  'Hydatidosis is a serious Public Health problem in the Province of Río Negro , Argentina .',
  'A hydatid cyst is still a serious health problem in endemic areas .',
  'Primary posterior mediastinal hydatid cyst is a serious health problem for the Mediterranean countries .',
  'Hydatid cyst disease is a parasitic infection caused by Echinococcus granulosus and poses a serious health problem in endemic areas , including our country .',
  'Hydatid disease of the liver still remains a serious medical problem .',
  'Hydatid disease is a serious public health problem in endemic areas .',
  'Hydatid disease remains a serious health problem for the Mediterranean countries , such as Turkey .',
  'A hydatid disease is a serious public health problem in Kazakhstan .',
  'Liver hydatidosis is a severe health problem in endemic areas .',
  'Hydatid cyst disease in childhood is still a serious health problem in the rural areas of Turkey and other places where the parasite is endemic .',
  'Liver hydatid disease remains a serious public health problem .',
  'Hydatid disease constitutes a serious public health problem throughout the world , especially in endemic areas , despite the use of various kinds of preventive measures .',
  'Hydatid cyst ( HC ) disease is a serious health problem in endemic areas .',
  'Hepatic hydatidosis still remains as a serious problem in general surgery .',
  'Hydatid disease in tropical areas poses a serious diagnostic problem due to the high frequence of cross-reactivity with other endemic helminthic infections .',
  'Recurrence of hepatic hydatid disease is still a serious problem in endemic areas like our country .',
  'Hydatidosis is a serious problem in non-endemic countries due to the influx of immigrants from nations where preventive measures are inadequate .',
  'Spinal hydatid disease is rare and remains a serious health problem associated with high rates of recurrence .',
  'Hepatic hydatid cysts are a serious medical problem in some regions like Mediterranean region .',
  'Hydatid disease is a serious health problem in Turkey .',
  'Hydatid cyst of the liver remains a serious public health problem in Tunisia .',
  'Hydatid cyst ( HC ) disease is a serious health problem in endemic areas , solitary primary subcutaneous hydatid cyst is not frequent and the only symptom is generally a silent growing mass .',
  'Mature eggs develop into hydatid cysts in different organs , leading to hydatid disease , which is a serious public health problem .',
  'Hydatidosis , or echincoccosis , is a serious medical and veterinary problem in many countries , particularly those with rural communities where there is a greater contact between dogs and domestic animals .',
  'Hydatid disease remains a serious health problem in Mediterranean countries .',
  'Hydatid disease of the lungs is still a serious health problem for some Mediterranean countries .',
  'Hydatid cyst ( HC ) is a serious health problem in developing countries .'],
 'cyst': ['Paraurethral cyst is a rare cause of interlabial mass in neonates with an incidence of 1 in every 2000-7000 live births and represents less than 0',
  'Hydatidosis constitutes a serious Public Health problem in the Province of Rio Negro , Argentine .',
  'Recurrence of hydatid cysts in cystectomy patients has dramatically remained a serious concern within the surgical community .',
  'Hydatid liver disease in children is a serious problem where the parasite is endemic .',
  'Hydatic disease has always been the most common in countries where large amount of sheep and cattle is raised , but increased travel and immigration have made this condition a serious worldwide public problem .',
  'Human hydatid cyst or cystic echinococcosis is a life-threatening zoonotic disease that occurs in most countries worldwide and is recognized as a major public health problem .',
  'Hydatid disease is a serious public health problem in endemic areas , and the management is controversial .',
  'Hydatic cyst of the liver remains a serious public health problem in Morocco and several other Mediterranean countries .',
  'Hydatid disease is a serious public health problem in developing countries .',
  'Hydatid disease in childhood is a serious health problem in Turkey and other places where the parasite is endemic .',
  'The study indicates that in Turkey hydatidosis remains a serious problem , causing blindness .',
  'Hydatid cysts are a serious health problem in many countries that raise farm animals , and they usually involve the liver and lungs .',
  'Nevertheless , hydatic disease is a serious public health problem in endemic areas .',
  'In Turkey , spinal hydatidosis remains a serious health problem that is associated with high morbidity and mortality .',
  'Hydatid illness still presents a serious surgical problem and in the case of obstrukioni ikterus an operation is indispensable method in the treatment of illness .',
  'Liver hydatid cyst with cystobiliary communication and superadded acute cholangitis is a serious clinical problem requiring the early diagnosis and surgery in the absence of endoscopic therapy .',
  'Hydatidosis is a serious Public Health problem in the Province of Río Negro , Argentina .',
  'A hydatid cyst is still a serious health problem in endemic areas .',
  'Primary posterior mediastinal hydatid cyst is a serious health problem for the Mediterranean countries .',
  'Hydatid cyst disease is a parasitic infection caused by Echinococcus granulosus and poses a serious health problem in endemic areas , including our country .',
  'Hydatid disease of the liver still remains a serious medical problem .',
  'Hydatid disease is a serious public health problem in endemic areas .',
  'Hydatid disease remains a serious health problem for the Mediterranean countries , such as Turkey .',
  'A hydatid disease is a serious public health problem in Kazakhstan .',
  'Liver hydatidosis is a severe health problem in endemic areas .',
  'Hydatid cyst disease in childhood is still a serious health problem in the rural areas of Turkey and other places where the parasite is endemic .',
  'Liver hydatid disease remains a serious public health problem .',
  'Hydatid disease constitutes a serious public health problem throughout the world , especially in endemic areas , despite the use of various kinds of preventive measures .',
  'Hydatid cyst ( HC ) disease is a serious health problem in endemic areas .',
  'Hepatic hydatidosis still remains as a serious problem in general surgery .',
  'Hydatid disease in tropical areas poses a serious diagnostic problem due to the high frequence of cross-reactivity with other endemic helminthic infections .',
  'Recurrence of hepatic hydatid disease is still a serious problem in endemic areas like our country .',
  'Hydatidosis is a serious problem in non-endemic countries due to the influx of immigrants from nations where preventive measures are inadequate .',
  'Spinal hydatid disease is rare and remains a serious health problem associated with high rates of recurrence .',
  'Hepatic hydatid cysts are a serious medical problem in some regions like Mediterranean region .',
  'Hydatid disease is a serious health problem in Turkey .',
  'Hydatid cyst of the liver remains a serious public health problem in Tunisia .',
  'Hydatid cyst ( HC ) disease is a serious health problem in endemic areas , solitary primary subcutaneous hydatid cyst is not frequent and the only symptom is generally a silent growing mass .',
  'Mature eggs develop into hydatid cysts in different organs , leading to hydatid disease , which is a serious public health problem .',
  'Hydatidosis , or echincoccosis , is a serious medical and veterinary problem in many countries , particularly those with rural communities where there is a greater contact between dogs and domestic animals .',
  'Hydatid disease remains a serious health problem in Mediterranean countries .',
  'Hydatid disease of the lungs is still a serious health problem for some Mediterranean countries .',
  'Hydatid cyst ( HC ) is a serious health problem in developing countries .'],
 'hydatidosis': ['Paraurethral cyst is a rare cause of interlabial mass in neonates with an incidence of 1 in every 2000-7000 live births and represents less than 0',
  'Hydatidosis constitutes a serious Public Health problem in the Province of Rio Negro , Argentine .',
  'Recurrence of hydatid cysts in cystectomy patients has dramatically remained a serious concern within the surgical community .',
  'Hydatid liver disease in children is a serious problem where the parasite is endemic .',
  'Hydatic disease has always been the most common in countries where large amount of sheep and cattle is raised , but increased travel and immigration have made this condition a serious worldwide public problem .',
  'Human hydatid cyst or cystic echinococcosis is a life-threatening zoonotic disease that occurs in most countries worldwide and is recognized as a major public health problem .',
  'Hydatid disease is a serious public health problem in endemic areas , and the management is controversial .',
  'Hydatic cyst of the liver remains a serious public health problem in Morocco and several other Mediterranean countries .',
  'Hydatid disease is a serious public health problem in developing countries .',
  'Hydatid disease in childhood is a serious health problem in Turkey and other places where the parasite is endemic .',
  'The study indicates that in Turkey hydatidosis remains a serious problem , causing blindness .',
  'Hydatid cysts are a serious health problem in many countries that raise farm animals , and they usually involve the liver and lungs .',
  'Nevertheless , hydatic disease is a serious public health problem in endemic areas .',
  'In Turkey , spinal hydatidosis remains a serious health problem that is associated with high morbidity and mortality .',
  'Hydatid illness still presents a serious surgical problem and in the case of obstrukioni ikterus an operation is indispensable method in the treatment of illness .',
  'Liver hydatid cyst with cystobiliary communication and superadded acute cholangitis is a serious clinical problem requiring the early diagnosis and surgery in the absence of endoscopic therapy .',
  'Hydatidosis is a serious Public Health problem in the Province of Río Negro , Argentina .',
  'A hydatid cyst is still a serious health problem in endemic areas .',
  'Primary posterior mediastinal hydatid cyst is a serious health problem for the Mediterranean countries .',
  'Hydatid cyst disease is a parasitic infection caused by Echinococcus granulosus and poses a serious health problem in endemic areas , including our country .',
  'Hydatid disease of the liver still remains a serious medical problem .',
  'Hydatid disease is a serious public health problem in endemic areas .',
  'Hydatid disease remains a serious health problem for the Mediterranean countries , such as Turkey .',
  'A hydatid disease is a serious public health problem in Kazakhstan .',
  'Liver hydatidosis is a severe health problem in endemic areas .',
  'Hydatid cyst disease in childhood is still a serious health problem in the rural areas of Turkey and other places where the parasite is endemic .',
  'Liver hydatid disease remains a serious public health problem .',
  'Hydatid disease constitutes a serious public health problem throughout the world , especially in endemic areas , despite the use of various kinds of preventive measures .',
  'Hydatid cyst ( HC ) disease is a serious health problem in endemic areas .',
  'Hepatic hydatidosis still remains as a serious problem in general surgery .',
  'Hydatid disease in tropical areas poses a serious diagnostic problem due to the high frequence of cross-reactivity with other endemic helminthic infections .',
  'Recurrence of hepatic hydatid disease is still a serious problem in endemic areas like our country .',
  'Hydatidosis is a serious problem in non-endemic countries due to the influx of immigrants from nations where preventive measures are inadequate .',
  'Spinal hydatid disease is rare and remains a serious health problem associated with high rates of recurrence .',
  'Hepatic hydatid cysts are a serious medical problem in some regions like Mediterranean region .',
  'Hydatid disease is a serious health problem in Turkey .',
  'Hydatid cyst of the liver remains a serious public health problem in Tunisia .',
  'Hydatid cyst ( HC ) disease is a serious health problem in endemic areas , solitary primary subcutaneous hydatid cyst is not frequent and the only symptom is generally a silent growing mass .',
  'Mature eggs develop into hydatid cysts in different organs , leading to hydatid disease , which is a serious public health problem .',
  'Hydatidosis , or echincoccosis , is a serious medical and veterinary problem in many countries , particularly those with rural communities where there is a greater contact between dogs and domestic animals .',
  'Hydatid disease remains a serious health problem in Mediterranean countries .',
  'Hydatid disease of the lungs is still a serious health problem for some Mediterranean countries .',
  'Hydatid cyst ( HC ) is a serious health problem in developing countries .'],
 'nephropathy': ['Diabetic kidney disease (DKD) is 1 of the common microvascular complications of diabetes, and the therapeutic effect of modern medicine on DKD is limited',
  'Although mechanical thrombectomy is a standard endovascular therapy for patients with acute ischemic stroke (AIS), the incidence of and risk factors for contrast-induced nephropathy (CIN) following mechanical thrombectomy are infrequently reported',
  'A major drawback of MSCT consists in the use of contrast dye , which may be unsafe in transcatheter aortic valve implantation ( TAVI ) patients who frequently are affected by renal failure .',
  'Diabetes mellitus is a debilitating health care problem affecting 382 million people around the world and one of the most common complications is diabetic nephropathy .',
  'Contrast-induced nephropathy ( CIN ) has become a serious problem for patients with pre-existing renal insufficiency undergoing percutaneous coronary intervention ( PCI ) .',
  'Diabetes mellitus is a serious health problem in the world and about 20 to 40 % of the patients are being affected with diabetic nephropathy .',
  'Diabetic renal disease is a serious problem resulting from microvascular complications in both type 1 and type 2 diabetes mellitus .',
  'Diabetic renal disease is a serious problem resulting from microvascular complications in both type 1 and type 2 diabetes mellitus .',
  'Contrast enhanced procedures are performed with increasing frequency and the patients population is progressively older and with multiple co-morbid conditions , thus contrast media toxicity is becoming a serious problem .',
  'Diabetic kidney disease ( DKD ) is a serious disease that presents a major health problem worldwide .',
  'The increased elimination of the dye occurring after small doses of various irritants , which is frequently characteristic of the early stages of a severe nephritis , and which is seen also several days after unilateral nephrectomy , would appear to have an important relation to the problem of kidney function ; and although probably not of clinical importance , it is worthy of further study as a phase of renal activity .',
  'Despite the development of new non-ionic low-osmolality contrast media , nephrotoxicity of intravascular radio-opaque contrast media remains a severe clinical problem , particularly in patients with risk factors .',
  'Contrast-induced nephropathy ( CIN ) is a serious clinical problem associated with increased morbidity and mortality , particularly in patients with chronic renal insufficiency .',
  'Diabetes mellitus is currently a serious public health problem worldwide , that increases the risk of presenting microvascular and macrovascular complications .',
  'Diabetic nephropathy ( DN ) that progress to end stage renal failure is a serious health problem .',
  'Contrast-induced acute kidney injury ( CI-AKI ) is a vexing problem , and more than 70 million patients undergo studies using iodinated contrast .',
  'With a developing worldwide epidemic of diabetes mellitus , the renal complications associated with diabetes have become a serious health concern .',
  'With worldwide epidemic of diabetes mellitus , diabetic nephropathy which is one of the major causes of microvascular complication has become a serious concern in Korea as well as the rest of the world .',
  'Nowadays diabetic nephropathy ( DN ) has become a serious problem .',
  'Diabetic angiopathy is a serious problem in antidiabetic therapy .',
  'Contrast-induced nephropathy ( CIN ) , caused by a combination of the direct tubular toxicity of contrast media , a reduction in medullary blood flow , and the generation of reactive oxygen species , is a serious clinical problem .',
  'Iodinated contrast media ( ICM ) hypersensitivity reactions represent a serious problem .',
  'Peripheral vascular disease is a serious and frequent problem in diabetic patients .',
  'Diabetic nephropathy ( DN ) is a serious complication of diabetes mellitus ( DM ) , which is a major public health problem in the world .',
  'Diabetic kidney disease , a leading cause of end-stage renal disease , has become a serious public health problem worldwide and lacks effective therapies .',
  'Diabetic nephropathy ( DN ) has become a serious public health problem .',
  'The prevention of contrast-induced nephropathy , which accounts for considerable morbidity and mortality , remains a vexing problem .',
  'Kidney disease is a serious development in diabetes mellitus and poses an increasing clinical problem .',
  'Diabetic kidney disease ( DKD ) , a leading cause of end-stage renal disease ( ESRD ) , has become a serious public health problem worldwide and lacks effective therapies due to its complex pathogenesis .',
  'The nephrotoxicity induced by contrast media remains a serious clinical problem , and the underlying mechanism has not been completely understood .'],
 'dkd': ['Diabetic kidney disease (DKD) is 1 of the common microvascular complications of diabetes, and the therapeutic effect of modern medicine on DKD is limited',
  'Diabetes mellitus is a debilitating health care problem affecting 382 million people around the world and one of the most common complications is diabetic nephropathy .',
  'Diabetes mellitus is a serious health problem in the world and about 20 to 40 % of the patients are being affected with diabetic nephropathy .',
  'Diabetic renal disease is a serious problem resulting from microvascular complications in both type 1 and type 2 diabetes mellitus .',
  'Diabetic renal disease is a serious problem resulting from microvascular complications in both type 1 and type 2 diabetes mellitus .',
  'Diabetic kidney disease ( DKD ) is a serious disease that presents a major health problem worldwide .',
  'Diabetes mellitus is currently a serious public health problem worldwide , that increases the risk of presenting microvascular and macrovascular complications .',
  'Diabetic nephropathy ( DN ) that progress to end stage renal failure is a serious health problem .',
  'With a developing worldwide epidemic of diabetes mellitus , the renal complications associated with diabetes have become a serious health concern .',
  'With worldwide epidemic of diabetes mellitus , diabetic nephropathy which is one of the major causes of microvascular complication has become a serious concern in Korea as well as the rest of the world .',
  'Nowadays diabetic nephropathy ( DN ) has become a serious problem .',
  'Diabetic angiopathy is a serious problem in antidiabetic therapy .',
  'Peripheral vascular disease is a serious and frequent problem in diabetic patients .',
  'Diabetic nephropathy ( DN ) is a serious complication of diabetes mellitus ( DM ) , which is a major public health problem in the world .',
  'Diabetic kidney disease , a leading cause of end-stage renal disease , has become a serious public health problem worldwide and lacks effective therapies .',
  'Diabetic nephropathy ( DN ) has become a serious public health problem .',
  'Kidney disease is a serious development in diabetes mellitus and poses an increasing clinical problem .',
  'Diabetic kidney disease ( DKD ) , a leading cause of end-stage renal disease ( ESRD ) , has become a serious public health problem worldwide and lacks effective therapies due to its complex pathogenesis .'],
 'microvascular': ['Diabetic kidney disease (DKD) is 1 of the common microvascular complications of diabetes, and the therapeutic effect of modern medicine on DKD is limited',
  'Diabetes mellitus is a debilitating health care problem affecting 382 million people around the world and one of the most common complications is diabetic nephropathy .',
  'Diabetes mellitus is a serious health problem in the world and about 20 to 40 % of the patients are being affected with diabetic nephropathy .',
  'Diabetic renal disease is a serious problem resulting from microvascular complications in both type 1 and type 2 diabetes mellitus .',
  'Diabetic renal disease is a serious problem resulting from microvascular complications in both type 1 and type 2 diabetes mellitus .',
  'Diabetic kidney disease ( DKD ) is a serious disease that presents a major health problem worldwide .',
  'Diabetes mellitus is currently a serious public health problem worldwide , that increases the risk of presenting microvascular and macrovascular complications .',
  'Diabetic nephropathy ( DN ) that progress to end stage renal failure is a serious health problem .',
  'With a developing worldwide epidemic of diabetes mellitus , the renal complications associated with diabetes have become a serious health concern .',
  'With worldwide epidemic of diabetes mellitus , diabetic nephropathy which is one of the major causes of microvascular complication has become a serious concern in Korea as well as the rest of the world .',
  'Nowadays diabetic nephropathy ( DN ) has become a serious problem .',
  'Diabetic angiopathy is a serious problem in antidiabetic therapy .',
  'Peripheral vascular disease is a serious and frequent problem in diabetic patients .',
  'Diabetic nephropathy ( DN ) is a serious complication of diabetes mellitus ( DM ) , which is a major public health problem in the world .',
  'Diabetic kidney disease , a leading cause of end-stage renal disease , has become a serious public health problem worldwide and lacks effective therapies .',
  'Diabetic nephropathy ( DN ) has become a serious public health problem .',
  'Kidney disease is a serious development in diabetes mellitus and poses an increasing clinical problem .',
  'Diabetic kidney disease ( DKD ) , a leading cause of end-stage renal disease ( ESRD ) , has become a serious public health problem worldwide and lacks effective therapies due to its complex pathogenesis .'],
 'drought': ['Reproductive-stage drought stress is a major impediment to rice production in rainfed areas',
  'Water shortage has become a serious problem for the sustainable development of irrigated agriculture in arid regions .',
  'Global increase in water scarcity is a serious problem for sustaining crop productivity .',
  'Abiotic stress poses constant challenges for plant survival and is a serious problem for global agricultural productivity .',
  'This experimental area was chosen because during the last 30 years , there has been a serious problem with the frequent occurrence of hydrological extremes , such as floods and droughts .',
  'Shrub expansion into desert grasslands is a serious problem resulting in loss of forage and rangeland productivity .',
  'Flooding due to global climate change is a serious problem that frequently decreases crop yields .',
  'Flooding is a serious problem for soybeans because it reduces growth and grain yield .',
  'Drought is a serious problem that causes losses in crop-yield every year , but the mechanisms underlying how roots respond to water deficit are difficult to study under controlled conditions .',
  'Drought is a serious , worldwide problem for crop production and also affects yields of barley and wheat , together with other stressors such as frost , viral diseases , or fungal pathogens .',
  'Flooding is a serious problem for soybean cultivation because it markedly reduces growth and grain yields .',
  'Drought stress is a serious problem worldwide that reduces crop productivity .',
  'Flooding stress of soybean is a serious problem because it reduces growth ; however , flooding-tolerant cultivars have not been identified .',
  'Flooding of rice fields is a serious problem in the river basins of South and South-East Asia where about 15 Mha of lowland rice cultivation is regularly affected .',
  'Arid regions pose a serious problem for crop production by suppressing plant growth .',
  'Drought is a restrictive factor for crop development and production , and is becoming a severe problem in many regions of the world .',
  'The potential for increased drought frequency and severity linked to anthropogenic climate change in the semi-arid regions of the southwestern United States ( US ) is a serious concern .',
  'Flooding is a serious problem for soybean cultivation because it markedly reduces growth .',
  'Most often it poses constrains in the growth hence productivity of the category of plants called glycophytes , wherein falls major crops , therefore is a serious concern .',
  'Drought ( water-deficit ) stress is a serious environmental problem in plant growth and cultivation .',
  'Drought is a serious and recurring problem for rural and remote Australia .',
  'Wheat demand will be increased by 60 % by 2050 which is a serious concern to meet this demand .',
  'Opportunities for water saving in maize systems exist , but water scarcity in China remains a serious problem .',
  'Since leaf dehydration in commercial sericulture is a serious problem , development of new methods that minimize post-harvest water loss are greatly needed .',
  'Plants are aerobic organisms for which oxygen shortage poses a severe problem .',
  'Food shortages have once again become a serious problem , not only because of world population growth but also as a result of escalating demand for crops as a substrate for biofuels .',
  'The results supported the idea that concentration polarization effects at the endodermis ( internal USLs ) cause a serious problem whenever relatively large amounts of water ( xylem sap ) are radially moved across the root , such as during PC or when using the high-pressure flow meter technique .',
  'Drought-induced tree death has become a serious problem in global forest ecosystems .'],
 'flooding': ['Reproductive-stage drought stress is a major impediment to rice production in rainfed areas',
  'Water shortage has become a serious problem for the sustainable development of irrigated agriculture in arid regions .',
  'Global increase in water scarcity is a serious problem for sustaining crop productivity .',
  'Abiotic stress poses constant challenges for plant survival and is a serious problem for global agricultural productivity .',
  'This experimental area was chosen because during the last 30 years , there has been a serious problem with the frequent occurrence of hydrological extremes , such as floods and droughts .',
  'Shrub expansion into desert grasslands is a serious problem resulting in loss of forage and rangeland productivity .',
  'Flooding due to global climate change is a serious problem that frequently decreases crop yields .',
  'Flooding is a serious problem for soybeans because it reduces growth and grain yield .',
  'Drought is a serious problem that causes losses in crop-yield every year , but the mechanisms underlying how roots respond to water deficit are difficult to study under controlled conditions .',
  'Drought is a serious , worldwide problem for crop production and also affects yields of barley and wheat , together with other stressors such as frost , viral diseases , or fungal pathogens .',
  'Flooding is a serious problem for soybean cultivation because it markedly reduces growth and grain yields .',
  'Drought stress is a serious problem worldwide that reduces crop productivity .',
  'Flooding stress of soybean is a serious problem because it reduces growth ; however , flooding-tolerant cultivars have not been identified .',
  'Flooding of rice fields is a serious problem in the river basins of South and South-East Asia where about 15 Mha of lowland rice cultivation is regularly affected .',
  'Arid regions pose a serious problem for crop production by suppressing plant growth .',
  'Drought is a restrictive factor for crop development and production , and is becoming a severe problem in many regions of the world .',
  'The potential for increased drought frequency and severity linked to anthropogenic climate change in the semi-arid regions of the southwestern United States ( US ) is a serious concern .',
  'Flooding is a serious problem for soybean cultivation because it markedly reduces growth .',
  'Most often it poses constrains in the growth hence productivity of the category of plants called glycophytes , wherein falls major crops , therefore is a serious concern .',
  'Drought ( water-deficit ) stress is a serious environmental problem in plant growth and cultivation .',
  'Drought is a serious and recurring problem for rural and remote Australia .',
  'Wheat demand will be increased by 60 % by 2050 which is a serious concern to meet this demand .',
  'Opportunities for water saving in maize systems exist , but water scarcity in China remains a serious problem .',
  'Since leaf dehydration in commercial sericulture is a serious problem , development of new methods that minimize post-harvest water loss are greatly needed .',
  'Plants are aerobic organisms for which oxygen shortage poses a severe problem .',
  'Food shortages have once again become a serious problem , not only because of world population growth but also as a result of escalating demand for crops as a substrate for biofuels .',
  'The results supported the idea that concentration polarization effects at the endodermis ( internal USLs ) cause a serious problem whenever relatively large amounts of water ( xylem sap ) are radially moved across the root , such as during PC or when using the high-pressure flow meter technique .',
  'Drought-induced tree death has become a serious problem in global forest ecosystems .'],
 'hf': ['Despite current therapies, acute heart failure (AHF) remains a major public health burden with high rates of in-hospital and post-discharge morbidity and mortality',
  'Acute cardiorenal syndrome (CRS) is a common clinical condition associated with adverse outcomes',
  'Heart failure ( HF ) is a life-threatening disease and is a growing public health concern .',
  'The prevalence of heart failure , as a serious health problem , is increasing around the world due to underlying factors , such as hypertension and diabetes .',
  '• Heart failure ( HF ) in children is a serious public health concern .',
  'Heart failure ( HF ) has been recognized as a pandemic and is a serious clinical and health problem associated with significant mortality , morbidity and expenditure on healthcare , especially among older people .',
  'Despite improved understanding of both disease mechanisms and the quality of care , congestive heart failure ( CHF ) remains a serious clinical problem .',
  'Hypertrophic obstructive cardiomyopathy ( HOCM ) is still a serious problem that is characterized by an increasing hypertrophy of the cardiac muscle .',
  'As heart failure ( HF ) is a devastating health problem worldwide , a better understanding and the development of more effective therapeutic approaches are required .',
  'Congestive heart failure is a serious health-care problem that is associated with a high mortality .',
  'Heart failure ( HF ) is a serious health problem in Spain because it has a high mortality rate and causes considerable costs to the health-care system .',
  'Heart failure ( HF ) represents a deadly epidemic that nowadays affects more than 2 % of the general population , representing a major public health concern that implies a high economic burden for the health system .',
  'Chronic heart failure after myocardial infarction is still a serious problem without a fundamental therapy .',
  'Management of patients with end-stage cardiac disease remains a vexing problem .',
  'Heart failure , a major cause of morbidity and mortality among the elderly , is a serious public health problem .',
  'Heart failure is a serious public health concern that afflicts millions of individuals in the United States .',
  'Heart Failure in Diabetes : Still a Vexing Problem .',
  'Heart failure is a serious worldwide health problem of major proportions .',
  'Heart failure ( HF ) is a chronic , systemic disorder that presents a serious and growing public health problem due to its high prevalence , mortality , and cost of care .',
  'Heart failure appears to be a severe public health problem affecting millions of people worldwide .',
  'Heart failure ( HF ) is a serious public health concern resulting in death .',
  'Moreover , despite many breakthroughs in cardiovascular medicine , the complications of a myocardial infarction such as chronic heart failure remains a serious worldwide problem .',
  'Heart failure has been identified as a serious international problem , in particular for aging groups , posing both an increasing number of patients on waiting lists in countries susceptible with Medicare systems and increasing financial burdens .',
  'This is to our knowledge the first report about the potential of an affordable , contactless , and unobtrusive ambient sensor system for the detection of early signs of HF decompensation based on data with prospective data acquisition and retrospective correlation of the data with clinical events in a 91 year old senior with a serious heart problem over 1 year .',
  'Type 4 cardiorenal syndrome ( CRS ) is a life-threatening world health problem in which chronic kidney disease leads to progressive cardiovascular disease .',
  'In spite of progress in diagnosis and treatment , hypertrophic obstructive cardiomyopathy ( HOCM ) remains a serious medical problem .',
  'Heart failure is a serious , common , and growing problem .',
  'Congestive heart failure ( CHF ) is a serious problem , responsible for one of the highest rates of hospitalization in the United States for any medical condition .',
  'Chronic heart failure ( CHF ) , the final phase of various heart diseases , is a serious public health problem resulting in high hospitalization rates , mortality , and increasing health care costs .',
  'Chronic heart failure ( CHF ) is a serious health problem today .',
  'Heart failure ( HF ) is a serious health-care problem .',
  'The treatment of advanced heart failure ( HF ) in children and infants poses a serious management problem .',
  'Heart failure ( HF ) is a severe public health problem because of its high morbidity and mortality and elevated costs , thus requiring better understanding of its course .',
  'Congestive heart failure is such a serious problem and the consequences of hospitalization so onerous in terms of patient well-being and costs to society that actual hemodynamic monitoring , despite its costs , is beneficial in carefully selected high-risk patients .',
  'Heart failure ( HF ) is a serious health-care problem .',
  'Acute decompensated heart failure ( ADHF ) is a serious clinical problem and a condition requiring immediate diagnostics , supporting the therapeutic decision adequate to the specific ADHF mechanism .',
  'Heart failure ( HF ) is a serious medical problem in the United States and is placing a financial strain on the health care system .',
  'Pharmacorefractory chronic heart failure is a serious world-wide problem of systolic dysfunction not improving despite evidence based chronic heart failure pharmacotherapy .',
  'Chronic heart failure ( CHF ) is a serious public health problem all over the world .',
  'Heart failure with preserved left ventricular ejection fraction ( HFpEF ) is a serious health problem worldwide , as no effective therapy is yet available .',
  'Congestive heart failure is a serious health problem in Western society .',
  'In the last few years , diastolic heart failure has become a serious clinical and epidemiological problem .',
  'Congestive Heart failure ( CHF ) is a severe pathology representing a major public health problem in industrialized nations which is increasing in prevalence and incidence .',
  'This is a serious problem as it seems to represent a final manifestation of congestive heart failure .',
  'Data on 9000 patients from the IN-CHF registry show that hospitalizations are a serious problem in Italy : 44 % of the patients had at least one hospitalization for heart failure in the year prior to the entry visit and this is the most powerful independent predictor of rehospitalization during the follow-up .',
  'The high and increasing prevalence of Dilated Cardiomyopathy ( DCM ) represents a serious public health problem .',
  'Chronic heart failure ( CHF ) is a serious public health problem associated with high rates of morbidity and mortality .',
  'Chronic heart failure after myocardial infarction is still a serious problem without a fundamental therapy .',
  'Chronic heart failure ( CHF ) , not only a severe personal healthy problem but also a social financial burden , has become a global health concern .',
  "Poor adherence to medical regimens is a serious problem that interferes with heart failure ( HF ) patients ' disease management and contributes to poor clinical outcomes ."],
 'chf': ['Despite current therapies, acute heart failure (AHF) remains a major public health burden with high rates of in-hospital and post-discharge morbidity and mortality',
  'Acute cardiorenal syndrome (CRS) is a common clinical condition associated with adverse outcomes',
  'Heart failure ( HF ) is a life-threatening disease and is a growing public health concern .',
  'The prevalence of heart failure , as a serious health problem , is increasing around the world due to underlying factors , such as hypertension and diabetes .',
  '• Heart failure ( HF ) in children is a serious public health concern .',
  'Heart failure ( HF ) has been recognized as a pandemic and is a serious clinical and health problem associated with significant mortality , morbidity and expenditure on healthcare , especially among older people .',
  'Despite improved understanding of both disease mechanisms and the quality of care , congestive heart failure ( CHF ) remains a serious clinical problem .',
  'Hypertrophic obstructive cardiomyopathy ( HOCM ) is still a serious problem that is characterized by an increasing hypertrophy of the cardiac muscle .',
  'As heart failure ( HF ) is a devastating health problem worldwide , a better understanding and the development of more effective therapeutic approaches are required .',
  'Congestive heart failure is a serious health-care problem that is associated with a high mortality .',
  'Heart failure ( HF ) is a serious health problem in Spain because it has a high mortality rate and causes considerable costs to the health-care system .',
  'Heart failure ( HF ) represents a deadly epidemic that nowadays affects more than 2 % of the general population , representing a major public health concern that implies a high economic burden for the health system .',
  'Chronic heart failure after myocardial infarction is still a serious problem without a fundamental therapy .',
  'Management of patients with end-stage cardiac disease remains a vexing problem .',
  'Heart failure , a major cause of morbidity and mortality among the elderly , is a serious public health problem .',
  'Heart failure is a serious public health concern that afflicts millions of individuals in the United States .',
  'Heart Failure in Diabetes : Still a Vexing Problem .',
  'Heart failure is a serious worldwide health problem of major proportions .',
  'Heart failure ( HF ) is a chronic , systemic disorder that presents a serious and growing public health problem due to its high prevalence , mortality , and cost of care .',
  'Heart failure appears to be a severe public health problem affecting millions of people worldwide .',
  'Heart failure ( HF ) is a serious public health concern resulting in death .',
  'Moreover , despite many breakthroughs in cardiovascular medicine , the complications of a myocardial infarction such as chronic heart failure remains a serious worldwide problem .',
  'Heart failure has been identified as a serious international problem , in particular for aging groups , posing both an increasing number of patients on waiting lists in countries susceptible with Medicare systems and increasing financial burdens .',
  'This is to our knowledge the first report about the potential of an affordable , contactless , and unobtrusive ambient sensor system for the detection of early signs of HF decompensation based on data with prospective data acquisition and retrospective correlation of the data with clinical events in a 91 year old senior with a serious heart problem over 1 year .',
  'Type 4 cardiorenal syndrome ( CRS ) is a life-threatening world health problem in which chronic kidney disease leads to progressive cardiovascular disease .',
  'In spite of progress in diagnosis and treatment , hypertrophic obstructive cardiomyopathy ( HOCM ) remains a serious medical problem .',
  'Heart failure is a serious , common , and growing problem .',
  'Congestive heart failure ( CHF ) is a serious problem , responsible for one of the highest rates of hospitalization in the United States for any medical condition .',
  'Chronic heart failure ( CHF ) , the final phase of various heart diseases , is a serious public health problem resulting in high hospitalization rates , mortality , and increasing health care costs .',
  'Chronic heart failure ( CHF ) is a serious health problem today .',
  'Heart failure ( HF ) is a serious health-care problem .',
  'The treatment of advanced heart failure ( HF ) in children and infants poses a serious management problem .',
  'Heart failure ( HF ) is a severe public health problem because of its high morbidity and mortality and elevated costs , thus requiring better understanding of its course .',
  'Congestive heart failure is such a serious problem and the consequences of hospitalization so onerous in terms of patient well-being and costs to society that actual hemodynamic monitoring , despite its costs , is beneficial in carefully selected high-risk patients .',
  'Heart failure ( HF ) is a serious health-care problem .',
  'Acute decompensated heart failure ( ADHF ) is a serious clinical problem and a condition requiring immediate diagnostics , supporting the therapeutic decision adequate to the specific ADHF mechanism .',
  'Heart failure ( HF ) is a serious medical problem in the United States and is placing a financial strain on the health care system .',
  'Pharmacorefractory chronic heart failure is a serious world-wide problem of systolic dysfunction not improving despite evidence based chronic heart failure pharmacotherapy .',
  'Chronic heart failure ( CHF ) is a serious public health problem all over the world .',
  'Heart failure with preserved left ventricular ejection fraction ( HFpEF ) is a serious health problem worldwide , as no effective therapy is yet available .',
  'Congestive heart failure is a serious health problem in Western society .',
  'In the last few years , diastolic heart failure has become a serious clinical and epidemiological problem .',
  'Congestive Heart failure ( CHF ) is a severe pathology representing a major public health problem in industrialized nations which is increasing in prevalence and incidence .',
  'This is a serious problem as it seems to represent a final manifestation of congestive heart failure .',
  'Data on 9000 patients from the IN-CHF registry show that hospitalizations are a serious problem in Italy : 44 % of the patients had at least one hospitalization for heart failure in the year prior to the entry visit and this is the most powerful independent predictor of rehospitalization during the follow-up .',
  'The high and increasing prevalence of Dilated Cardiomyopathy ( DCM ) represents a serious public health problem .',
  'Chronic heart failure ( CHF ) is a serious public health problem associated with high rates of morbidity and mortality .',
  'Chronic heart failure after myocardial infarction is still a serious problem without a fundamental therapy .',
  'Chronic heart failure ( CHF ) , not only a severe personal healthy problem but also a social financial burden , has become a global health concern .',
  "Poor adherence to medical regimens is a serious problem that interferes with heart failure ( HF ) patients ' disease management and contributes to poor clinical outcomes ."],
 'dysphagia': ['Dysphagia is a common symptom that occurs in patients with diabetes mellitus (DM)',
  'Dysphagia also causes a severe drawback of the overall quality of life .',
  'Swallowing disorders are a serious health concern among older adults .',
  'Definition , prevalence and burden of oropharyngeal dysphagia : a serious problem among older adults worldwide and the impact on prognosis and hospital resources .',
  "Although dysphagia is a life-threatening problem in patients with Parkinson 's disease ( PD ) , the pathophysiology of oropharyngeal dysphagia is yet to be understood .",
  'Dysphagia is a serious and at times presenting problem in patients with inflammatory myopathy .',
  'Dysphagia is a serious problem for many patients ; there is a correlation between grade of dysphagia and four QoL dimensions .',
  'Dysphagia is a serious health problem in aging populations .',
  'Dysphagia is a serious health problem that affects persons of all ages , from the neonate to those of advanced age .',
  'It is , however a serious medical problem that may require otolaryngologic intervention because of life-threatening dysphagia and weight loss .',
  'Dysphagia can be a serious problem in patients with inflammatory myopathies .',
  'For the bulbar ALS/MND patient with dysphagia , the accumulation of oral secretions is a distressing problem .',
  'Symptoms of dysphonia can be very early evidence of a serious problem , either within the larynx or resulting from a systemic disease .',
  'Although dysphagia is a life-threatening problem in patients with Duchenne muscular dystrophy ( DMD ) , the pathophysiology of oral stage dysphagia is yet to be understood .'],
 'oropharyngeal': ['Dysphagia is a common symptom that occurs in patients with diabetes mellitus (DM)',
  'Dysphagia also causes a severe drawback of the overall quality of life .',
  'Swallowing disorders are a serious health concern among older adults .',
  'Definition , prevalence and burden of oropharyngeal dysphagia : a serious problem among older adults worldwide and the impact on prognosis and hospital resources .',
  "Although dysphagia is a life-threatening problem in patients with Parkinson 's disease ( PD ) , the pathophysiology of oropharyngeal dysphagia is yet to be understood .",
  'Dysphagia is a serious and at times presenting problem in patients with inflammatory myopathy .',
  'Dysphagia is a serious problem for many patients ; there is a correlation between grade of dysphagia and four QoL dimensions .',
  'Dysphagia is a serious health problem in aging populations .',
  'Dysphagia is a serious health problem that affects persons of all ages , from the neonate to those of advanced age .',
  'It is , however a serious medical problem that may require otolaryngologic intervention because of life-threatening dysphagia and weight loss .',
  'Dysphagia can be a serious problem in patients with inflammatory myopathies .',
  'For the bulbar ALS/MND patient with dysphagia , the accumulation of oral secretions is a distressing problem .',
  'Symptoms of dysphonia can be very early evidence of a serious problem , either within the larynx or resulting from a systemic disease .',
  'Although dysphagia is a life-threatening problem in patients with Duchenne muscular dystrophy ( DMD ) , the pathophysiology of oral stage dysphagia is yet to be understood .'],
 'covid': ['Coronavirus disease 2019 (COVID-19), a novel pneumonia disease originating in Wuhan, was confirmed by the World Health Organization on January 12, 2020 before becoming an outbreak in all countries',
  'Coronavirus Disease 2019 (COVID-19) is a disease that presents with acute respiratory symptoms that are well documented and sequelae that are yet to be fully understood',
  'The Evidence possibly supporting or disputing this hypothesis is reviewed , however the major problem with the hypothesis is that to date no coronavirus has ever been isolated from arthropods .',
  'A drawback of the current mRNA-lipid nanoparticle ( LNP ) COVID-19 vaccines is that they have to be stored at (ultra)low temperatures .',
  'Nowadays , Covid-19 is considered a serious health problem worldwide .',
  'The morbidity of SARS-CoV-2 ( COVID-19 ) is reaching 3 Million landmark causing and a serious public health concern globally and it is enigmatic how several antiviral and antibody treatments were not effective in the different period across the globe .',
  'COVID-19 remains a serious emerging global health problem , and little is known about the role of oropharynx commensal microbes in infection susceptibility and severity .',
  'Since the COVID-19 pandemic became a serious health concern globally , patients with chronic diseases have required close attention with regard to general risks and individual treatment .',
  'The Coronavirus Disease 2019 ( COVID-19 ) pandemic remains a serious public health problem and will continue to be until effective drugs and/or vaccines are available .',
  'Middle East respiratory syndrome coronavirus ( MERS-CoV ) is an emerging zoonotic viral pathogen and a serious public health concern .',
  'The coronavirus disease 2019 ( COVID-19 ) pandemic is a serious public health concern , with an exponentially growing number of patients worldwide .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a serious public health problem worldwide .',
  'The coronavirus disease 2019 ( COVID-19 ) has become a serious problem for public health since it was identified in the province of Wuhan ( China ) and spread around the world producing high mortality rates and economic losses .',
  'However , due to the worldwide spread of the virus , COVID-19 has become a serious concern in the medical community .',
  'BACKGROUND Coronavirus disease ( COVID 19 ) is caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) and is the causative agent of a serious disease that is of great global public health concern .',
  'The pandemic of coronavirus disease 2019 ( COVID-19 ) , caused by a newly identified β-coronavirus ( SARS-CoV-2 ) has emerged as a dire health problem , causing a massive crisis for global health .',
  'The COVID-19 epidemic has been a major global public health problem during past months in Italy and in several other Countries and on the date of publication of this article , is still a serious public health problem .',
  'Moreover , not only COVID-19 was appropriately acknowledged as a severe disease by only 62.0 % of respondents , with no differences between HCWs and non-HCWs , but an even smaller share ( i.e. 8.0 % ) reported any concern for being infected by SARS-CoV-2 in Italy .',
  'A severe outbreak of coronavirus disease 2019 ( COVID-19 ) emerged in China in December 2019 , and spread so rapidly that more than 200,000 cases have so far been reported worldwide ; on January 30 , 2020 , the WHO declared it the sixth public health emergency of international concern .',
  'Infection caused by the new coronavirus ( SARS-CoV-2 ) has become a serious worldwide public health problem , and one of the most important strategies for its control is mass testing .',
  'The pandemic due to novel coronavirus , SARS-CoV-2 is a serious global concern now .',
  'Coronavirus disease 2019 ( COVID-19 ) as a life-threatening disease is caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) that is accounted as global public health concern .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a severe public health problem globally .',
  'The severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) outbreak is a serious health concern .',
  'The Covid-19 is a highly contagious disease which becomes a serious global health concern .',
  'The coronavirus outbreak emerged as a severe pandemic , claiming more than 0.8 million lives across the world and raised a major global health concern .',
  'Because SARS-CoV-2 is highly infectious due to contamination in the air , there is a high risk of infection in the dental environment which is represents a serious problem for professionals and students ( dentistry and dental hygiene ) .',
  'The COVID-19-associated CoV is a beta coronavirus , which spreads at such a deadly rate that the World Health Organization ( WHO ) has to declare it a Public Health Emergency of International Concern ( PHEIC ) .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a serious public health problem worldwide .',
  'There is a serious concern over the variation of case fatality of COVID-19 patients that reflects the preparedness of the medical care system in response to the surge of pneumonia patients .',
  'MIS-C associated with COVID-19 is a severe presentation of SARS-CoV-2 infection and of a major concern as an overlapping features with other diseases could happen , making the diagnosis challenging .',
  'The potential for infection by coronaviruses ( CoVs ) has become a serious concern with the recent emergence of Middle East respiratory syndrome and severe acute respiratory syndrome ( SARS ) in the human population .',
  'Alcohol-based disinfectant shortage is a serious concern in the severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) pandemic .',
  'The pandemic is now expected to remain a vexing health problem for months and perhaps years to come , and the implications for health promotion and disease prevention have taken on new importance given the need for ongoing attention to acute and long-term issues .',
  'Coronavirus Disease 2019 ( COVID-19 ) caused by the novel severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) has become a severe public health problem with a high rate of morbidity and mortality .',
  'The Covid 19 pandemic remains a serious public health problem until effective drugs and/or vaccines are available .',
  'Because Sars-CoV-2 is highly infective through airborne contamination , the high infection risk in the dental environment is a serious problem for both professional practitioners and patients .',
  'The COVID-19 outbreak has become a serious public health problem worldwide .',
  'The COVID-19 pandemic caused by SARS-CoV-2 has become a serious concern among the global medical community and has resulted in an unprecedented psychological impact on health care workers , who were already working under stressful conditions .',
  'While immunosuppressants are known to achieve control and lower steroid dependence in T2LR , the prospect of managing a severe T2LR in conjunction with COVID-19 , with the concern of worsening COVID-19 with long-term immunosuppression has not previously been encountered .',
  'At the start of the 21st century , respiratory syncytial virus ( RSV ) remains a serious global health concern .',
  'Such current findings impede researchers from recommending an appropriate and effective antiviral therapy against COVID-19 , making it a serious concern for the global community .',
  'The sudden COVID-19 pandemic has caused a serious global concern due to infections and mortality rates .',
  'COVID-19 is a severe health problem in many countries and has altered day-to-day life in the whole world .',
  'The continued global pandemic of coronavirus disease 2019 ( COVID-19 ) poses a serious threat to global public health and social stability and it has become a serious global public health problem .',
  'At present , novel coronavirus disease 2019 ( COVID-19 ) has become a serious global public health problem .',
  'We found that 86.7 % of students regarded frequent hand washing as the most important means of protection against COVID-19 , and 19.3 % of students did not regard the COVID-19 pandemic as a severe public health problem for Turkey at that moment .',
  'Multiple organ failure in COVID-19 patients is a serious problem which can result in a fatal outcome .',
  'The new outbreak of Coronavirus Disease 2019 ( COVID-19 ) has emerged as a serious global public health concern .',
  'SARS-CoV-2 has become a pandemic causing a serious global health concern .',
  'COVID-19 emerged in late 2019 and quickly became a serious public health problem worldwide .',
  'Coronavirus disease 2019 ( COVID-19 ) is a serious health concern which affects all healthcare professionals worldwide .',
  'Vaccines for SARS , MERS and RSV have never been approved , and the data generated in the development and testing of these vaccines suggest a serious mechanistic concern : that vaccines designed empirically using the traditional approach ( consisting of the unmodified or minimally modified coronavirus viral spike to elicit neutralising antibodies ) , be they composed of protein , viral vector , DNA or RNA and irrespective of delivery method , may worsen COVID-19 disease via antibody-dependent enhancement ( ADE ) .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a serious public health problem for \xa0\xa0\xa0  183 out of 197 countries in the world .',
  'Because Sars-CoV-2 is highly infective through airborne contamination , the high infection risk in the dental environment is a serious problem for both professional practitioners and patients .',
  'The emergence of viral respiratory pathogens with pandemic potential , such as severe acute respiratory syndrome coronavirus ( SARS-CoV ) , the pathogenic agent of Covid-19 , represent a serious health problem worldwide .',
  'Geriatric care in public health emergencies is a serious concern , while , high case-fatalities among older adults across the globe in COVID-19 pandemic implies lack of preparedness .',
  'Disseminated intravascular coagulation : A devastating systemic disorder of special concern with COVID-19 .',
  'Hospital-acquired COVID-19 represents a serious public health issue , which is a problem that could create reluctance of patients to seek hospital treatment for fear of becoming infected .',
  'The management of healthcare services for the suspected cases in non-designated hospitalsis a serious concern in controlling coronavirus disease 2019 ( COVID-19 ) epidemic .',
  'The novel coronavirus disease 2019 ( COVID-19 ) caused by severe acute respiratory syndrome coronavirus-2 infection is a serious global concern .',
  'An outbreak of coronavirus disease ( COVID-19 ) in Wuhan , China caused by SARS-CoV-2 has led to a serious epidemic in China and other countries , resulting in worldwide concern .',
  'Middle East respiratory syndrome coronavirus ( MERS-CoV ) infections continue to be a serious emerging disease problem internationally with well over 1000 cases and a major outbreak outside of the Middle East region .',
  'Several studies have pointed to their inadequacy , which is becoming a serious problem during the global crisis due to the Covid-19 pandemic .',
  'We examined how the thoughts , feelings , and behaviors of 6,957 students from Germany , assessed between March 16 and April 21 , 2020 , when COVID-19 became a serious health concern in Germany , varied by personality .',
  'The current evidence impede researchers from proposing an appropriate antiviral therapy against COVID-19 , making the current situation a serious concern for international organizations such as World Health Organization ( WHO ) .',
  'Severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) is the causative agent of the ongoing coronavirus disease 2019 ( COVID-19 ) pandemic that is a serious global health problem .',
  'Respiratory syncytial virus infection remains a serious health problem , not only in infants but also in immunocompromised adults and the elderly .',
  'Since SARS showed a severe case fatality ratio , our concern is to know such a case fatality ratio as soon as possible after a similar outbreak begins .',
  'We report a severe case of COVID-19 in a patient with chronic lymphocytic leukemia and describe primarily the clinical presentation and the challenges encountered in the COVID-19 diagnosis , treatment , and specimens sampling pitfalls .',
  'COVID-19 is a severe problem for many countries and to control and prevent the spread of this problem , the lockdown approach has been implemented in many countries , including India .',
  'Severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) infection is now a serious public health problem .',
  'The emergences of coronaviruses have caused a serious global public health problem because their infection in humans caused the severe acute respiratory disease and deaths .',
  'Global pandemics are a serious concern for developing countries , perhaps particularly when the same pandemic also affects donors of development aid .',
  'The rapid outbreak of the novel severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) in China followed by its spread around the world poses a serious global concern for public health .',
  'This is a serious concern when linked to the pandemic .',
  'The novel COVID-19 infection is a severe public health problem which is causing an increasing number of deaths worldwide .',
  'Delay in vaccine production is a serious problem in responding to a pandemic situation , such as that of the current H1N1 strain .',
  'Severe acute respiratory syndrome coronavirus-2 ( SARS-CoV-2 ) has caused a serious epidemic in our country and all over the world since December 2019 and has become a global health problem .',
  'The highly contagious nature of human respiratory syncytial virus ( HRSV ) and the gravity of its infection in newborns and vulnerable adults pose a serious public health problem .',
  'The detected increase in the total number of deaths and age-adjusted rates of sarcoidosis deaths in the U.S. is a serious health concern .',
  'However , dropout from care during this pandemic remains a serious concern .',
  'Respiratory syncytial virus ( RSV ) infection is a serious health problem in young children , immunocompromised patients , and the elderly .',
  'The COVID-19 pandemic , caused by severe acute respiratory syndrome corona virus 2 ( SARS-CoV-2 ) , has become a severe global health problem affecting almost every country in the world .',
  'The results of this review indicated that COVID-19 is a serious global public health problem .',
  'The outbreak of COVID-19 has created a serious public health concern worldwide .',
  "Pandemics constitute a serious problem to global health with a major impact on the affected countries ' populations .",
  'The spread of coronavirus 2019 ( COVID-19 ) is a serious problem all over the world .',
  'Coronavirus infection is a serious health problem awaiting an effective vaccine and/or antiviral treatment .',
  'Although our data may be incomplete and must be interpreted with caution , inconsistencies in reporting COVID-19 cases is a serious problem which might sabotage efforts to contain the virus .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a severe public health problem around the globe .',
  'In this review , we review the cardiovascular manifestations of COVID-19 and describe our system-wide adaptations to the pandemic , including the use of telemedicine , how a severe reduction in operative volume affected our programme , the process of redeployment of staff , repurposing of residents into specific task teams , the creation of operation room intensive care units , and the challenges that we faced in this process .',
  'While the coronavirus disease ( COVID-19 ) accounts for the current global pandemic , the emergence of other unknown pathogens , named " Disease X , " remains a serious concern in the future .',
  'In this review , we review the cardiovascular manifestations of COVID-19 and describe our system-wide adaptations to the pandemic , including the use of telemedicine , how a severe reduction in operative volume affected our program , the process of redeployment of staff , repurposing of residents into specific task teams , the creation of operation room intensive care units , and the challenges that we faced in this process .',
  'Because of the human-to-human transmission and rapid spread ; coronavirus disease 2019 ( COVID-19 ) has rapidly increased to an epidemic scale and poses a severe threat to human health ; it has been declared a public health emergency of international concern ( PHEIC ) by the World Health Organization ( WHO ) .',
  'SARS-CoV2 viral manifestation poses a serious human life risk by causing acute lung injury and various respiratory outcomes and has become a global concern .',
  'The coronavirus disease 2019 ( COVID-19 ) pandemic has become a serious global health problem and numerous studies are currently being conducted to improve understanding of the components of the severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) virus , as well as to identify solutions that mitigate the effects of COVID-19 symptoms .',
  'The severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) pandemic posed a serious public health concern and started a race against time for researchers to discover an effective and safe therapy for coronavirus disease 2019 ( COVID-19 ) , the disease caused by SARS-CoV-2 .',
  'As a severe and highly contagious infection , coronavirus disease ( COVID-19 ) affects all aspects of society and has become a global public health problem .',
  'Considering the expected availability of a severe acute respiratory syndrome coronavirus 2 vaccine for distribution and dispensing to the public , our findings highlight critical considerations for planning possible future mass vaccination events , including during the novel coronavirus disease 2019 pandemic .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a serious public health problem worldwide .',
  'Hurricane Maria : A Preventable Humanitarian and Health Care Crisis Unveiling the Puerto Rican Dilemma .',
  '" SARS-CoV2 " , a previously unknown strain of coronaviruses caused a severe respiratory disease called Coronavirus disease ( COVID-19 ) which emerged from Wuhan city of China on 30 December 2019 , and declared as Global health problem by World Health Organisation within a month .',
  'At the end of 2019 , the COVID-19 pandemic began , which at the time of writing continues to be a serious problem for many areas of medicine , including neurology .',
  'Based on 4,040 SARS CoV-2 RT-PCR tests , an exit test 96 hours after the start of quarantine for an offshore oil rig population was demonstrated to identify all known asymptomatic cases that previously tested negative at entry , and-moreover-successfully prevented an expected seven or more offshore transmission events , each a serious concern for initiating rapid spread and a disabling outbreak in the close quarters of an offshore rig .',
  'Middle East respiratory syndrome coronavirus ( MERS-CoV ) recently emerged as a severe worldwide public health concern .',
  'Coronavirus-19 causing a severe acute respiratory disorder in humans and becoming a major health problem .',
  'As COVID-19 is posing a serious threat to global health , the emerging mutation in SARS-CoV-2 genomes , for example , N501Y substitution , is one of the major challenges against control of the pandemic .',
  'During the 2003 severe acute respiratory syndrome ( SARS ) outbreak in Toronto , the potential introduction of SARS into the homeless population was a serious concern .',
  'The COVID-19 outbreak is a serious health problem to human beings .',
  'In this review , we review the cardiovascular manifestations of COVID-19 and describe our system-wide adaptations to the pandemic , including the use of telemedicine , how a severe reduction in operative volume affected our program , the process of redeployment of staff , repurposing of residents into specific task teams , the creation of operation room intensive care units , and the challenges that we faced in this process .'],
 'coronavirus': ['Coronavirus disease 2019 (COVID-19), a novel pneumonia disease originating in Wuhan, was confirmed by the World Health Organization on January 12, 2020 before becoming an outbreak in all countries',
  'Coronavirus Disease 2019 (COVID-19) is a disease that presents with acute respiratory symptoms that are well documented and sequelae that are yet to be fully understood',
  'The Evidence possibly supporting or disputing this hypothesis is reviewed , however the major problem with the hypothesis is that to date no coronavirus has ever been isolated from arthropods .',
  'A drawback of the current mRNA-lipid nanoparticle ( LNP ) COVID-19 vaccines is that they have to be stored at (ultra)low temperatures .',
  'Nowadays , Covid-19 is considered a serious health problem worldwide .',
  'The morbidity of SARS-CoV-2 ( COVID-19 ) is reaching 3 Million landmark causing and a serious public health concern globally and it is enigmatic how several antiviral and antibody treatments were not effective in the different period across the globe .',
  'COVID-19 remains a serious emerging global health problem , and little is known about the role of oropharynx commensal microbes in infection susceptibility and severity .',
  'Since the COVID-19 pandemic became a serious health concern globally , patients with chronic diseases have required close attention with regard to general risks and individual treatment .',
  'The Coronavirus Disease 2019 ( COVID-19 ) pandemic remains a serious public health problem and will continue to be until effective drugs and/or vaccines are available .',
  'Middle East respiratory syndrome coronavirus ( MERS-CoV ) is an emerging zoonotic viral pathogen and a serious public health concern .',
  'The coronavirus disease 2019 ( COVID-19 ) pandemic is a serious public health concern , with an exponentially growing number of patients worldwide .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a serious public health problem worldwide .',
  'The coronavirus disease 2019 ( COVID-19 ) has become a serious problem for public health since it was identified in the province of Wuhan ( China ) and spread around the world producing high mortality rates and economic losses .',
  'However , due to the worldwide spread of the virus , COVID-19 has become a serious concern in the medical community .',
  'BACKGROUND Coronavirus disease ( COVID 19 ) is caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) and is the causative agent of a serious disease that is of great global public health concern .',
  'The pandemic of coronavirus disease 2019 ( COVID-19 ) , caused by a newly identified β-coronavirus ( SARS-CoV-2 ) has emerged as a dire health problem , causing a massive crisis for global health .',
  'The COVID-19 epidemic has been a major global public health problem during past months in Italy and in several other Countries and on the date of publication of this article , is still a serious public health problem .',
  'Moreover , not only COVID-19 was appropriately acknowledged as a severe disease by only 62.0 % of respondents , with no differences between HCWs and non-HCWs , but an even smaller share ( i.e. 8.0 % ) reported any concern for being infected by SARS-CoV-2 in Italy .',
  'A severe outbreak of coronavirus disease 2019 ( COVID-19 ) emerged in China in December 2019 , and spread so rapidly that more than 200,000 cases have so far been reported worldwide ; on January 30 , 2020 , the WHO declared it the sixth public health emergency of international concern .',
  'Infection caused by the new coronavirus ( SARS-CoV-2 ) has become a serious worldwide public health problem , and one of the most important strategies for its control is mass testing .',
  'The pandemic due to novel coronavirus , SARS-CoV-2 is a serious global concern now .',
  'Coronavirus disease 2019 ( COVID-19 ) as a life-threatening disease is caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) that is accounted as global public health concern .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a severe public health problem globally .',
  'The severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) outbreak is a serious health concern .',
  'The Covid-19 is a highly contagious disease which becomes a serious global health concern .',
  'The coronavirus outbreak emerged as a severe pandemic , claiming more than 0.8 million lives across the world and raised a major global health concern .',
  'Because SARS-CoV-2 is highly infectious due to contamination in the air , there is a high risk of infection in the dental environment which is represents a serious problem for professionals and students ( dentistry and dental hygiene ) .',
  'The COVID-19-associated CoV is a beta coronavirus , which spreads at such a deadly rate that the World Health Organization ( WHO ) has to declare it a Public Health Emergency of International Concern ( PHEIC ) .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a serious public health problem worldwide .',
  'There is a serious concern over the variation of case fatality of COVID-19 patients that reflects the preparedness of the medical care system in response to the surge of pneumonia patients .',
  'MIS-C associated with COVID-19 is a severe presentation of SARS-CoV-2 infection and of a major concern as an overlapping features with other diseases could happen , making the diagnosis challenging .',
  'The potential for infection by coronaviruses ( CoVs ) has become a serious concern with the recent emergence of Middle East respiratory syndrome and severe acute respiratory syndrome ( SARS ) in the human population .',
  'Alcohol-based disinfectant shortage is a serious concern in the severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) pandemic .',
  'The pandemic is now expected to remain a vexing health problem for months and perhaps years to come , and the implications for health promotion and disease prevention have taken on new importance given the need for ongoing attention to acute and long-term issues .',
  'Coronavirus Disease 2019 ( COVID-19 ) caused by the novel severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) has become a severe public health problem with a high rate of morbidity and mortality .',
  'The Covid 19 pandemic remains a serious public health problem until effective drugs and/or vaccines are available .',
  'Because Sars-CoV-2 is highly infective through airborne contamination , the high infection risk in the dental environment is a serious problem for both professional practitioners and patients .',
  'The COVID-19 outbreak has become a serious public health problem worldwide .',
  'The COVID-19 pandemic caused by SARS-CoV-2 has become a serious concern among the global medical community and has resulted in an unprecedented psychological impact on health care workers , who were already working under stressful conditions .',
  'While immunosuppressants are known to achieve control and lower steroid dependence in T2LR , the prospect of managing a severe T2LR in conjunction with COVID-19 , with the concern of worsening COVID-19 with long-term immunosuppression has not previously been encountered .',
  'At the start of the 21st century , respiratory syncytial virus ( RSV ) remains a serious global health concern .',
  'Such current findings impede researchers from recommending an appropriate and effective antiviral therapy against COVID-19 , making it a serious concern for the global community .',
  'The sudden COVID-19 pandemic has caused a serious global concern due to infections and mortality rates .',
  'COVID-19 is a severe health problem in many countries and has altered day-to-day life in the whole world .',
  'The continued global pandemic of coronavirus disease 2019 ( COVID-19 ) poses a serious threat to global public health and social stability and it has become a serious global public health problem .',
  'At present , novel coronavirus disease 2019 ( COVID-19 ) has become a serious global public health problem .',
  'We found that 86.7 % of students regarded frequent hand washing as the most important means of protection against COVID-19 , and 19.3 % of students did not regard the COVID-19 pandemic as a severe public health problem for Turkey at that moment .',
  'Multiple organ failure in COVID-19 patients is a serious problem which can result in a fatal outcome .',
  'The new outbreak of Coronavirus Disease 2019 ( COVID-19 ) has emerged as a serious global public health concern .',
  'SARS-CoV-2 has become a pandemic causing a serious global health concern .',
  'COVID-19 emerged in late 2019 and quickly became a serious public health problem worldwide .',
  'Coronavirus disease 2019 ( COVID-19 ) is a serious health concern which affects all healthcare professionals worldwide .',
  'Vaccines for SARS , MERS and RSV have never been approved , and the data generated in the development and testing of these vaccines suggest a serious mechanistic concern : that vaccines designed empirically using the traditional approach ( consisting of the unmodified or minimally modified coronavirus viral spike to elicit neutralising antibodies ) , be they composed of protein , viral vector , DNA or RNA and irrespective of delivery method , may worsen COVID-19 disease via antibody-dependent enhancement ( ADE ) .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a serious public health problem for \xa0\xa0\xa0  183 out of 197 countries in the world .',
  'Because Sars-CoV-2 is highly infective through airborne contamination , the high infection risk in the dental environment is a serious problem for both professional practitioners and patients .',
  'The emergence of viral respiratory pathogens with pandemic potential , such as severe acute respiratory syndrome coronavirus ( SARS-CoV ) , the pathogenic agent of Covid-19 , represent a serious health problem worldwide .',
  'Geriatric care in public health emergencies is a serious concern , while , high case-fatalities among older adults across the globe in COVID-19 pandemic implies lack of preparedness .',
  'Disseminated intravascular coagulation : A devastating systemic disorder of special concern with COVID-19 .',
  'Hospital-acquired COVID-19 represents a serious public health issue , which is a problem that could create reluctance of patients to seek hospital treatment for fear of becoming infected .',
  'The management of healthcare services for the suspected cases in non-designated hospitalsis a serious concern in controlling coronavirus disease 2019 ( COVID-19 ) epidemic .',
  'The novel coronavirus disease 2019 ( COVID-19 ) caused by severe acute respiratory syndrome coronavirus-2 infection is a serious global concern .',
  'An outbreak of coronavirus disease ( COVID-19 ) in Wuhan , China caused by SARS-CoV-2 has led to a serious epidemic in China and other countries , resulting in worldwide concern .',
  'Middle East respiratory syndrome coronavirus ( MERS-CoV ) infections continue to be a serious emerging disease problem internationally with well over 1000 cases and a major outbreak outside of the Middle East region .',
  'Several studies have pointed to their inadequacy , which is becoming a serious problem during the global crisis due to the Covid-19 pandemic .',
  'We examined how the thoughts , feelings , and behaviors of 6,957 students from Germany , assessed between March 16 and April 21 , 2020 , when COVID-19 became a serious health concern in Germany , varied by personality .',
  'The current evidence impede researchers from proposing an appropriate antiviral therapy against COVID-19 , making the current situation a serious concern for international organizations such as World Health Organization ( WHO ) .',
  'Severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) is the causative agent of the ongoing coronavirus disease 2019 ( COVID-19 ) pandemic that is a serious global health problem .',
  'Respiratory syncytial virus infection remains a serious health problem , not only in infants but also in immunocompromised adults and the elderly .',
  'Since SARS showed a severe case fatality ratio , our concern is to know such a case fatality ratio as soon as possible after a similar outbreak begins .',
  'We report a severe case of COVID-19 in a patient with chronic lymphocytic leukemia and describe primarily the clinical presentation and the challenges encountered in the COVID-19 diagnosis , treatment , and specimens sampling pitfalls .',
  'COVID-19 is a severe problem for many countries and to control and prevent the spread of this problem , the lockdown approach has been implemented in many countries , including India .',
  'Severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) infection is now a serious public health problem .',
  'The emergences of coronaviruses have caused a serious global public health problem because their infection in humans caused the severe acute respiratory disease and deaths .',
  'Global pandemics are a serious concern for developing countries , perhaps particularly when the same pandemic also affects donors of development aid .',
  'The rapid outbreak of the novel severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) in China followed by its spread around the world poses a serious global concern for public health .',
  'This is a serious concern when linked to the pandemic .',
  'The novel COVID-19 infection is a severe public health problem which is causing an increasing number of deaths worldwide .',
  'Delay in vaccine production is a serious problem in responding to a pandemic situation , such as that of the current H1N1 strain .',
  'Severe acute respiratory syndrome coronavirus-2 ( SARS-CoV-2 ) has caused a serious epidemic in our country and all over the world since December 2019 and has become a global health problem .',
  'The highly contagious nature of human respiratory syncytial virus ( HRSV ) and the gravity of its infection in newborns and vulnerable adults pose a serious public health problem .',
  'The detected increase in the total number of deaths and age-adjusted rates of sarcoidosis deaths in the U.S. is a serious health concern .',
  'However , dropout from care during this pandemic remains a serious concern .',
  'Respiratory syncytial virus ( RSV ) infection is a serious health problem in young children , immunocompromised patients , and the elderly .',
  'The COVID-19 pandemic , caused by severe acute respiratory syndrome corona virus 2 ( SARS-CoV-2 ) , has become a severe global health problem affecting almost every country in the world .',
  'The results of this review indicated that COVID-19 is a serious global public health problem .',
  'The outbreak of COVID-19 has created a serious public health concern worldwide .',
  "Pandemics constitute a serious problem to global health with a major impact on the affected countries ' populations .",
  'The spread of coronavirus 2019 ( COVID-19 ) is a serious problem all over the world .',
  'Coronavirus infection is a serious health problem awaiting an effective vaccine and/or antiviral treatment .',
  'Although our data may be incomplete and must be interpreted with caution , inconsistencies in reporting COVID-19 cases is a serious problem which might sabotage efforts to contain the virus .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a severe public health problem around the globe .',
  'In this review , we review the cardiovascular manifestations of COVID-19 and describe our system-wide adaptations to the pandemic , including the use of telemedicine , how a severe reduction in operative volume affected our programme , the process of redeployment of staff , repurposing of residents into specific task teams , the creation of operation room intensive care units , and the challenges that we faced in this process .',
  'While the coronavirus disease ( COVID-19 ) accounts for the current global pandemic , the emergence of other unknown pathogens , named " Disease X , " remains a serious concern in the future .',
  'In this review , we review the cardiovascular manifestations of COVID-19 and describe our system-wide adaptations to the pandemic , including the use of telemedicine , how a severe reduction in operative volume affected our program , the process of redeployment of staff , repurposing of residents into specific task teams , the creation of operation room intensive care units , and the challenges that we faced in this process .',
  'Because of the human-to-human transmission and rapid spread ; coronavirus disease 2019 ( COVID-19 ) has rapidly increased to an epidemic scale and poses a severe threat to human health ; it has been declared a public health emergency of international concern ( PHEIC ) by the World Health Organization ( WHO ) .',
  'SARS-CoV2 viral manifestation poses a serious human life risk by causing acute lung injury and various respiratory outcomes and has become a global concern .',
  'The coronavirus disease 2019 ( COVID-19 ) pandemic has become a serious global health problem and numerous studies are currently being conducted to improve understanding of the components of the severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) virus , as well as to identify solutions that mitigate the effects of COVID-19 symptoms .',
  'The severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) pandemic posed a serious public health concern and started a race against time for researchers to discover an effective and safe therapy for coronavirus disease 2019 ( COVID-19 ) , the disease caused by SARS-CoV-2 .',
  'As a severe and highly contagious infection , coronavirus disease ( COVID-19 ) affects all aspects of society and has become a global public health problem .',
  'Considering the expected availability of a severe acute respiratory syndrome coronavirus 2 vaccine for distribution and dispensing to the public , our findings highlight critical considerations for planning possible future mass vaccination events , including during the novel coronavirus disease 2019 pandemic .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a serious public health problem worldwide .',
  'Hurricane Maria : A Preventable Humanitarian and Health Care Crisis Unveiling the Puerto Rican Dilemma .',
  '" SARS-CoV2 " , a previously unknown strain of coronaviruses caused a severe respiratory disease called Coronavirus disease ( COVID-19 ) which emerged from Wuhan city of China on 30 December 2019 , and declared as Global health problem by World Health Organisation within a month .',
  'At the end of 2019 , the COVID-19 pandemic began , which at the time of writing continues to be a serious problem for many areas of medicine , including neurology .',
  'Based on 4,040 SARS CoV-2 RT-PCR tests , an exit test 96 hours after the start of quarantine for an offshore oil rig population was demonstrated to identify all known asymptomatic cases that previously tested negative at entry , and-moreover-successfully prevented an expected seven or more offshore transmission events , each a serious concern for initiating rapid spread and a disabling outbreak in the close quarters of an offshore rig .',
  'Middle East respiratory syndrome coronavirus ( MERS-CoV ) recently emerged as a severe worldwide public health concern .',
  'Coronavirus-19 causing a severe acute respiratory disorder in humans and becoming a major health problem .',
  'As COVID-19 is posing a serious threat to global health , the emerging mutation in SARS-CoV-2 genomes , for example , N501Y substitution , is one of the major challenges against control of the pandemic .',
  'During the 2003 severe acute respiratory syndrome ( SARS ) outbreak in Toronto , the potential introduction of SARS into the homeless population was a serious concern .',
  'The COVID-19 outbreak is a serious health problem to human beings .',
  'In this review , we review the cardiovascular manifestations of COVID-19 and describe our system-wide adaptations to the pandemic , including the use of telemedicine , how a severe reduction in operative volume affected our program , the process of redeployment of staff , repurposing of residents into specific task teams , the creation of operation room intensive care units , and the challenges that we faced in this process .'],
 'sars': ['Coronavirus disease 2019 (COVID-19), a novel pneumonia disease originating in Wuhan, was confirmed by the World Health Organization on January 12, 2020 before becoming an outbreak in all countries',
  'Coronavirus Disease 2019 (COVID-19) is a disease that presents with acute respiratory symptoms that are well documented and sequelae that are yet to be fully understood',
  'The Evidence possibly supporting or disputing this hypothesis is reviewed , however the major problem with the hypothesis is that to date no coronavirus has ever been isolated from arthropods .',
  'A drawback of the current mRNA-lipid nanoparticle ( LNP ) COVID-19 vaccines is that they have to be stored at (ultra)low temperatures .',
  'Nowadays , Covid-19 is considered a serious health problem worldwide .',
  'The morbidity of SARS-CoV-2 ( COVID-19 ) is reaching 3 Million landmark causing and a serious public health concern globally and it is enigmatic how several antiviral and antibody treatments were not effective in the different period across the globe .',
  'COVID-19 remains a serious emerging global health problem , and little is known about the role of oropharynx commensal microbes in infection susceptibility and severity .',
  'Since the COVID-19 pandemic became a serious health concern globally , patients with chronic diseases have required close attention with regard to general risks and individual treatment .',
  'The Coronavirus Disease 2019 ( COVID-19 ) pandemic remains a serious public health problem and will continue to be until effective drugs and/or vaccines are available .',
  'Middle East respiratory syndrome coronavirus ( MERS-CoV ) is an emerging zoonotic viral pathogen and a serious public health concern .',
  'The coronavirus disease 2019 ( COVID-19 ) pandemic is a serious public health concern , with an exponentially growing number of patients worldwide .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a serious public health problem worldwide .',
  'The coronavirus disease 2019 ( COVID-19 ) has become a serious problem for public health since it was identified in the province of Wuhan ( China ) and spread around the world producing high mortality rates and economic losses .',
  'However , due to the worldwide spread of the virus , COVID-19 has become a serious concern in the medical community .',
  'BACKGROUND Coronavirus disease ( COVID 19 ) is caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) and is the causative agent of a serious disease that is of great global public health concern .',
  'The pandemic of coronavirus disease 2019 ( COVID-19 ) , caused by a newly identified β-coronavirus ( SARS-CoV-2 ) has emerged as a dire health problem , causing a massive crisis for global health .',
  'The COVID-19 epidemic has been a major global public health problem during past months in Italy and in several other Countries and on the date of publication of this article , is still a serious public health problem .',
  'Moreover , not only COVID-19 was appropriately acknowledged as a severe disease by only 62.0 % of respondents , with no differences between HCWs and non-HCWs , but an even smaller share ( i.e. 8.0 % ) reported any concern for being infected by SARS-CoV-2 in Italy .',
  'A severe outbreak of coronavirus disease 2019 ( COVID-19 ) emerged in China in December 2019 , and spread so rapidly that more than 200,000 cases have so far been reported worldwide ; on January 30 , 2020 , the WHO declared it the sixth public health emergency of international concern .',
  'Infection caused by the new coronavirus ( SARS-CoV-2 ) has become a serious worldwide public health problem , and one of the most important strategies for its control is mass testing .',
  'The pandemic due to novel coronavirus , SARS-CoV-2 is a serious global concern now .',
  'Coronavirus disease 2019 ( COVID-19 ) as a life-threatening disease is caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) that is accounted as global public health concern .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a severe public health problem globally .',
  'The severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) outbreak is a serious health concern .',
  'The Covid-19 is a highly contagious disease which becomes a serious global health concern .',
  'The coronavirus outbreak emerged as a severe pandemic , claiming more than 0.8 million lives across the world and raised a major global health concern .',
  'Because SARS-CoV-2 is highly infectious due to contamination in the air , there is a high risk of infection in the dental environment which is represents a serious problem for professionals and students ( dentistry and dental hygiene ) .',
  'The COVID-19-associated CoV is a beta coronavirus , which spreads at such a deadly rate that the World Health Organization ( WHO ) has to declare it a Public Health Emergency of International Concern ( PHEIC ) .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a serious public health problem worldwide .',
  'There is a serious concern over the variation of case fatality of COVID-19 patients that reflects the preparedness of the medical care system in response to the surge of pneumonia patients .',
  'MIS-C associated with COVID-19 is a severe presentation of SARS-CoV-2 infection and of a major concern as an overlapping features with other diseases could happen , making the diagnosis challenging .',
  'The potential for infection by coronaviruses ( CoVs ) has become a serious concern with the recent emergence of Middle East respiratory syndrome and severe acute respiratory syndrome ( SARS ) in the human population .',
  'Alcohol-based disinfectant shortage is a serious concern in the severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) pandemic .',
  'The pandemic is now expected to remain a vexing health problem for months and perhaps years to come , and the implications for health promotion and disease prevention have taken on new importance given the need for ongoing attention to acute and long-term issues .',
  'Coronavirus Disease 2019 ( COVID-19 ) caused by the novel severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) has become a severe public health problem with a high rate of morbidity and mortality .',
  'The Covid 19 pandemic remains a serious public health problem until effective drugs and/or vaccines are available .',
  'Because Sars-CoV-2 is highly infective through airborne contamination , the high infection risk in the dental environment is a serious problem for both professional practitioners and patients .',
  'The COVID-19 outbreak has become a serious public health problem worldwide .',
  'The COVID-19 pandemic caused by SARS-CoV-2 has become a serious concern among the global medical community and has resulted in an unprecedented psychological impact on health care workers , who were already working under stressful conditions .',
  'While immunosuppressants are known to achieve control and lower steroid dependence in T2LR , the prospect of managing a severe T2LR in conjunction with COVID-19 , with the concern of worsening COVID-19 with long-term immunosuppression has not previously been encountered .',
  'At the start of the 21st century , respiratory syncytial virus ( RSV ) remains a serious global health concern .',
  'Such current findings impede researchers from recommending an appropriate and effective antiviral therapy against COVID-19 , making it a serious concern for the global community .',
  'The sudden COVID-19 pandemic has caused a serious global concern due to infections and mortality rates .',
  'COVID-19 is a severe health problem in many countries and has altered day-to-day life in the whole world .',
  'The continued global pandemic of coronavirus disease 2019 ( COVID-19 ) poses a serious threat to global public health and social stability and it has become a serious global public health problem .',
  'At present , novel coronavirus disease 2019 ( COVID-19 ) has become a serious global public health problem .',
  'We found that 86.7 % of students regarded frequent hand washing as the most important means of protection against COVID-19 , and 19.3 % of students did not regard the COVID-19 pandemic as a severe public health problem for Turkey at that moment .',
  'Multiple organ failure in COVID-19 patients is a serious problem which can result in a fatal outcome .',
  'The new outbreak of Coronavirus Disease 2019 ( COVID-19 ) has emerged as a serious global public health concern .',
  'SARS-CoV-2 has become a pandemic causing a serious global health concern .',
  'COVID-19 emerged in late 2019 and quickly became a serious public health problem worldwide .',
  'Coronavirus disease 2019 ( COVID-19 ) is a serious health concern which affects all healthcare professionals worldwide .',
  'Vaccines for SARS , MERS and RSV have never been approved , and the data generated in the development and testing of these vaccines suggest a serious mechanistic concern : that vaccines designed empirically using the traditional approach ( consisting of the unmodified or minimally modified coronavirus viral spike to elicit neutralising antibodies ) , be they composed of protein , viral vector , DNA or RNA and irrespective of delivery method , may worsen COVID-19 disease via antibody-dependent enhancement ( ADE ) .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a serious public health problem for \xa0\xa0\xa0  183 out of 197 countries in the world .',
  'Because Sars-CoV-2 is highly infective through airborne contamination , the high infection risk in the dental environment is a serious problem for both professional practitioners and patients .',
  'The emergence of viral respiratory pathogens with pandemic potential , such as severe acute respiratory syndrome coronavirus ( SARS-CoV ) , the pathogenic agent of Covid-19 , represent a serious health problem worldwide .',
  'Geriatric care in public health emergencies is a serious concern , while , high case-fatalities among older adults across the globe in COVID-19 pandemic implies lack of preparedness .',
  'Disseminated intravascular coagulation : A devastating systemic disorder of special concern with COVID-19 .',
  'Hospital-acquired COVID-19 represents a serious public health issue , which is a problem that could create reluctance of patients to seek hospital treatment for fear of becoming infected .',
  'The management of healthcare services for the suspected cases in non-designated hospitalsis a serious concern in controlling coronavirus disease 2019 ( COVID-19 ) epidemic .',
  'The novel coronavirus disease 2019 ( COVID-19 ) caused by severe acute respiratory syndrome coronavirus-2 infection is a serious global concern .',
  'An outbreak of coronavirus disease ( COVID-19 ) in Wuhan , China caused by SARS-CoV-2 has led to a serious epidemic in China and other countries , resulting in worldwide concern .',
  'Middle East respiratory syndrome coronavirus ( MERS-CoV ) infections continue to be a serious emerging disease problem internationally with well over 1000 cases and a major outbreak outside of the Middle East region .',
  'Several studies have pointed to their inadequacy , which is becoming a serious problem during the global crisis due to the Covid-19 pandemic .',
  'We examined how the thoughts , feelings , and behaviors of 6,957 students from Germany , assessed between March 16 and April 21 , 2020 , when COVID-19 became a serious health concern in Germany , varied by personality .',
  'The current evidence impede researchers from proposing an appropriate antiviral therapy against COVID-19 , making the current situation a serious concern for international organizations such as World Health Organization ( WHO ) .',
  'Severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) is the causative agent of the ongoing coronavirus disease 2019 ( COVID-19 ) pandemic that is a serious global health problem .',
  'Respiratory syncytial virus infection remains a serious health problem , not only in infants but also in immunocompromised adults and the elderly .',
  'Since SARS showed a severe case fatality ratio , our concern is to know such a case fatality ratio as soon as possible after a similar outbreak begins .',
  'We report a severe case of COVID-19 in a patient with chronic lymphocytic leukemia and describe primarily the clinical presentation and the challenges encountered in the COVID-19 diagnosis , treatment , and specimens sampling pitfalls .',
  'COVID-19 is a severe problem for many countries and to control and prevent the spread of this problem , the lockdown approach has been implemented in many countries , including India .',
  'Severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) infection is now a serious public health problem .',
  'The emergences of coronaviruses have caused a serious global public health problem because their infection in humans caused the severe acute respiratory disease and deaths .',
  'Global pandemics are a serious concern for developing countries , perhaps particularly when the same pandemic also affects donors of development aid .',
  'The rapid outbreak of the novel severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) in China followed by its spread around the world poses a serious global concern for public health .',
  'This is a serious concern when linked to the pandemic .',
  'The novel COVID-19 infection is a severe public health problem which is causing an increasing number of deaths worldwide .',
  'Delay in vaccine production is a serious problem in responding to a pandemic situation , such as that of the current H1N1 strain .',
  'Severe acute respiratory syndrome coronavirus-2 ( SARS-CoV-2 ) has caused a serious epidemic in our country and all over the world since December 2019 and has become a global health problem .',
  'The highly contagious nature of human respiratory syncytial virus ( HRSV ) and the gravity of its infection in newborns and vulnerable adults pose a serious public health problem .',
  'The detected increase in the total number of deaths and age-adjusted rates of sarcoidosis deaths in the U.S. is a serious health concern .',
  'However , dropout from care during this pandemic remains a serious concern .',
  'Respiratory syncytial virus ( RSV ) infection is a serious health problem in young children , immunocompromised patients , and the elderly .',
  'The COVID-19 pandemic , caused by severe acute respiratory syndrome corona virus 2 ( SARS-CoV-2 ) , has become a severe global health problem affecting almost every country in the world .',
  'The results of this review indicated that COVID-19 is a serious global public health problem .',
  'The outbreak of COVID-19 has created a serious public health concern worldwide .',
  "Pandemics constitute a serious problem to global health with a major impact on the affected countries ' populations .",
  'The spread of coronavirus 2019 ( COVID-19 ) is a serious problem all over the world .',
  'Coronavirus infection is a serious health problem awaiting an effective vaccine and/or antiviral treatment .',
  'Although our data may be incomplete and must be interpreted with caution , inconsistencies in reporting COVID-19 cases is a serious problem which might sabotage efforts to contain the virus .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a severe public health problem around the globe .',
  'In this review , we review the cardiovascular manifestations of COVID-19 and describe our system-wide adaptations to the pandemic , including the use of telemedicine , how a severe reduction in operative volume affected our programme , the process of redeployment of staff , repurposing of residents into specific task teams , the creation of operation room intensive care units , and the challenges that we faced in this process .',
  'While the coronavirus disease ( COVID-19 ) accounts for the current global pandemic , the emergence of other unknown pathogens , named " Disease X , " remains a serious concern in the future .',
  'In this review , we review the cardiovascular manifestations of COVID-19 and describe our system-wide adaptations to the pandemic , including the use of telemedicine , how a severe reduction in operative volume affected our program , the process of redeployment of staff , repurposing of residents into specific task teams , the creation of operation room intensive care units , and the challenges that we faced in this process .',
  'Because of the human-to-human transmission and rapid spread ; coronavirus disease 2019 ( COVID-19 ) has rapidly increased to an epidemic scale and poses a severe threat to human health ; it has been declared a public health emergency of international concern ( PHEIC ) by the World Health Organization ( WHO ) .',
  'SARS-CoV2 viral manifestation poses a serious human life risk by causing acute lung injury and various respiratory outcomes and has become a global concern .',
  'The coronavirus disease 2019 ( COVID-19 ) pandemic has become a serious global health problem and numerous studies are currently being conducted to improve understanding of the components of the severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) virus , as well as to identify solutions that mitigate the effects of COVID-19 symptoms .',
  'The severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) pandemic posed a serious public health concern and started a race against time for researchers to discover an effective and safe therapy for coronavirus disease 2019 ( COVID-19 ) , the disease caused by SARS-CoV-2 .',
  'As a severe and highly contagious infection , coronavirus disease ( COVID-19 ) affects all aspects of society and has become a global public health problem .',
  'Considering the expected availability of a severe acute respiratory syndrome coronavirus 2 vaccine for distribution and dispensing to the public , our findings highlight critical considerations for planning possible future mass vaccination events , including during the novel coronavirus disease 2019 pandemic .',
  'Coronavirus disease 2019 ( COVID-19 ) has become a serious public health problem worldwide .',
  'Hurricane Maria : A Preventable Humanitarian and Health Care Crisis Unveiling the Puerto Rican Dilemma .',
  '" SARS-CoV2 " , a previously unknown strain of coronaviruses caused a severe respiratory disease called Coronavirus disease ( COVID-19 ) which emerged from Wuhan city of China on 30 December 2019 , and declared as Global health problem by World Health Organisation within a month .',
  'At the end of 2019 , the COVID-19 pandemic began , which at the time of writing continues to be a serious problem for many areas of medicine , including neurology .',
  'Based on 4,040 SARS CoV-2 RT-PCR tests , an exit test 96 hours after the start of quarantine for an offshore oil rig population was demonstrated to identify all known asymptomatic cases that previously tested negative at entry , and-moreover-successfully prevented an expected seven or more offshore transmission events , each a serious concern for initiating rapid spread and a disabling outbreak in the close quarters of an offshore rig .',
  'Middle East respiratory syndrome coronavirus ( MERS-CoV ) recently emerged as a severe worldwide public health concern .',
  'Coronavirus-19 causing a severe acute respiratory disorder in humans and becoming a major health problem .',
  'As COVID-19 is posing a serious threat to global health , the emerging mutation in SARS-CoV-2 genomes , for example , N501Y substitution , is one of the major challenges against control of the pandemic .',
  'During the 2003 severe acute respiratory syndrome ( SARS ) outbreak in Toronto , the potential introduction of SARS into the homeless population was a serious concern .',
  'The COVID-19 outbreak is a serious health problem to human beings .',
  'In this review , we review the cardiovascular manifestations of COVID-19 and describe our system-wide adaptations to the pandemic , including the use of telemedicine , how a severe reduction in operative volume affected our program , the process of redeployment of staff , repurposing of residents into specific task teams , the creation of operation room intensive care units , and the challenges that we faced in this process .'],
 'metastases': ['The skeleton is one of the frequent site of metastases in advanced cancer',
  'A major problem with CIBP in humans is that it increases on weight-bearing and/or movement of a tumor-bearing bone limiting the activity and functional status of the patient .',
  'The problem with imaging bone metastases is that capromab detects an antigenic site on the intracellular portion of PSMA-a site not accessible to circulating antibodies .',
  'Therefore , IL-18 may be useful for suppression of osteolytic bone metastasis which is a serious problem in patients of advanced breast cancers .',
  'Especially , pain secondary to bone metastases is a serious problem in many patients with metastatic cancer .',
  'Bone metastases are a severe problem in oncology , since they usually are associated with pain .',
  'Bone metastases to the acetabulum and pelvis can be a devastating and debilitating problem .',
  'Bone metastases remain a serious health concern because of limited therapeutic options .',
  'Metastatic calcification progressed but was never a severe clinical problem .',
  'The diagnosis of primary tumors with inaugural bone metastases is a serious and difficult problem commonly encountered in rheumatology .',
  'Pain is a serious and common problem in bone metastases .',
  'Bone incidents today represent , in terms of frequency and the overall effect on the quality of life of patients with breast cancer , a serious health problem .',
  'Pathological fractures and osteolyses with impending fractures of long bones impose a severe problem in patients with advanced cancer .',
  'Bone metastasis is a serious problem for individuals with prostate cancer , and the effects of the anticancer drug docetaxel ( DTX ) are insufficient .',
  'Bone marrow injury remains a serious concern in traditional cancer treatment .',
  'Bone metastases represent a devastating clinical problem in the most frequent neoplasies , especially in multiple myeloma , tumours breast , prostate and lung .',
  'Metastatic bone disease is found in 80 - 90 % of patients examined after death and is a serious problem in everyday practice .',
  'Ensuring the diagnosis , prevention , and treatment of long-term toxicities and comorbid conditions like osteoporosis in breast carcinoma survivors is a serious concern and is of increasing importance .',
  "Bone metastases are a serious problem in patients with advanced cancer disease and their presence usually signifies serious morbidity prior to the patient 's death .",
  'The metastasis of breast cancer to the skeleton is a serious clinical problem resulting in hypercalcemia , bone fragility and insurmountable pain .',
  'Metastatic bone disease is a serious clinical problem in patients with advanced cancer .',
  'Pathologic fracture of the hip due to metastatic lesions in bone is a serious problem .'],
 'metastatic': ['The skeleton is one of the frequent site of metastases in advanced cancer',
  'A major problem with CIBP in humans is that it increases on weight-bearing and/or movement of a tumor-bearing bone limiting the activity and functional status of the patient .',
  'The problem with imaging bone metastases is that capromab detects an antigenic site on the intracellular portion of PSMA-a site not accessible to circulating antibodies .',
  'Therefore , IL-18 may be useful for suppression of osteolytic bone metastasis which is a serious problem in patients of advanced breast cancers .',
  'Especially , pain secondary to bone metastases is a serious problem in many patients with metastatic cancer .',
  'Bone metastases are a severe problem in oncology , since they usually are associated with pain .',
  'Bone metastases to the acetabulum and pelvis can be a devastating and debilitating problem .',
  'Bone metastases remain a serious health concern because of limited therapeutic options .',
  'Metastatic calcification progressed but was never a severe clinical problem .',
  'The diagnosis of primary tumors with inaugural bone metastases is a serious and difficult problem commonly encountered in rheumatology .',
  'Pain is a serious and common problem in bone metastases .',
  'Bone incidents today represent , in terms of frequency and the overall effect on the quality of life of patients with breast cancer , a serious health problem .',
  'Pathological fractures and osteolyses with impending fractures of long bones impose a severe problem in patients with advanced cancer .',
  'Bone metastasis is a serious problem for individuals with prostate cancer , and the effects of the anticancer drug docetaxel ( DTX ) are insufficient .',
  'Bone marrow injury remains a serious concern in traditional cancer treatment .',
  'Bone metastases represent a devastating clinical problem in the most frequent neoplasies , especially in multiple myeloma , tumours breast , prostate and lung .',
  'Metastatic bone disease is found in 80 - 90 % of patients examined after death and is a serious problem in everyday practice .',
  'Ensuring the diagnosis , prevention , and treatment of long-term toxicities and comorbid conditions like osteoporosis in breast carcinoma survivors is a serious concern and is of increasing importance .',
  "Bone metastases are a serious problem in patients with advanced cancer disease and their presence usually signifies serious morbidity prior to the patient 's death .",
  'The metastasis of breast cancer to the skeleton is a serious clinical problem resulting in hypercalcemia , bone fragility and insurmountable pain .',
  'Metastatic bone disease is a serious clinical problem in patients with advanced cancer .',
  'Pathologic fracture of the hip due to metastatic lesions in bone is a serious problem .'],
 'hearing': ['It is believed that poor classroom acoustics leads to lower levels of student learning and exposes teachers vocal folds to greater physical wear and tear',
  'One limitation , in most current digital hearing instruments with 16-bit analog-to-digital ( A/D ) converters , is that the compressor before the A/D conversion is limited to 95 dB ( SPL ) or less at the input .',
  'The problem with this postulate is that the electrical source and mechanical load for the electromechanical outer hair cell might be severely attenuated and phase-shifted by the electrical impedance of the cell and the mechanical impedance of the organ of Corti , respectively .',
  'A significant problem with automatic detectors is that they tend to partially detect whistles or break whistles into several parts .',
  'This study although provides evidence that air traffic noise is a serious cause of concern .',
  'Noise-induced hearing loss ( NIHL ) is a serious health concern and prevention of hair cell death or therapeutic intervention at the early stage of NIHL is critical to preserve hearing .',
  'Voice disorders constitute a serious health problem for teachers .',
  'Permanent childhood hearing impairment is a serious public health problem .',
  'Further , most participants were still not aware of the risk of NIHL to them from exposure to excessive noise during matches and did not consider hearing loss from noise exposure during soccer matches a serious concern both before and after the tournament .',
  'The low-pass characteristic of the outer hair cell ( OHC ) voltage response to mechanical stimulation could be considered a serious problem for cochlear models aiming at explaining high-frequency active amplification by introducing instantaneous nonlinear terms because active gain would dramatically decrease at high frequency .',
  'Excessive noise exposure is a serious global urban health problem , adversely affecting millions of people .',
  "High noise levels have been recognized as a serious problem in hospital environments during both night- and daytime , and have been associated with a negative impact on patients ' health status .",
  'Sensorineural hearing loss ( SNHL ) is a serious public health problem which affects 1 - 3 % per hundred live born babies in developed countries .',
  'This document is intended to inform the practice of hearing care professionals who are involved in the audiological management of adults with a severe to profound degree of hearing loss and will highlight the special considerations and practices required to optimize outcomes for these individuals .',
  'These findings suggest that acculturative stress is a serious concern among deaf undergraduate students and that the SAFE-D can be used to assess deaf acculturative stress in this population .',
  'Hearing loss from occupational exposures is a serious and widespread problem .',
  'Hearing loss is the most common sensory deficit in the elderly , and it is becoming a severe social and health problem .',
  'Noise induced hearing loss ( NIHL ) remains as a severe health problem worldwide .',
  '2 . Hearing loss is a serious health problem among the elderly .',
  'Ninety-five per cent of the respondents were aware that loud noise could damage their hearing , 90 % considered that a hearing loss would be a serious problem , and 85 % believed that HPDs could protect their hearing .',
  'Noise pollution is a severe public health problem as continuous exposure to even moderate noise levels between 55 - 65 dB can lead to various pathologies , including neurological states .',
  'Tinnitus , which is a distressing problem affecting many people around the world , is commonly referred to as ringing in the ears .',
  'The effect of acute noise on cognitive function has long been a topic of study , yet these effects remain a serious problem for learning performance in school children .',
  'The gap between the technology supported by policy and the technologies currently being used by deaf and hard of hearing people has become a serious problem that is difficult to solve because of the separate jurisdictions of the two agencies , the need for coordination within the FCC , technological challenges , and funding issues .',
  'Exposure to continuous loud noise is a serious health problem due to excess production of oxygen free radicals .',
  'A troublesome problem for some of these individuals is the retention of a male voice .',
  'Noise pollution in urban cities is a serious problem and steadily increasing over the years .',
  "Since noise was first recognized as a serious environmental pollutant , a number of social surveys have been conducted in order to assess the magnitude of the problem and to develop suitable noise ratings , such that , from a measurement of certain physical characteristics of community noise , one could reliably predict the community 's subjective response to the noise .",
  'Tinnitus is defined as a sound in the ear(s ) and/or head without external origin and is a serious health concern for millions worldwide .',
  'However , an MPO that is too low , as in the cases to avoid discomfort for people with a severe loudness tolerance problem and hearing losses that exceed the fitting range of the hearing aids , could negatively affect sound quality and speech intelligibility in noise .',
  'Hearing loss is a serious problem in infants and children because it may interfere with the development of typical speech , verbal language , and auditory and communication skills .',
  'Impaired hearing is a serious problem .',
  'Idiopathic sudden sensorineural hearing loss ( ISSNHL ) is a vexing problem that continues to pose a diagnostic and therapeutic enigma for the otologist .',
  'Sleep disturbance induced by night-time noise is a serious environmental problem that can cause adverse health effects , such as hypertension and ischemic heart disease .',
  'Hearing loss is the most common sensory deficit in the elderly , and is becoming a severe social and health problem .',
  'Noise pollution is recognized as a serious human health problem in modern society .',
  'With a prevalence of 5 in 1000 newborns with a hearing disorder , the congenital hearing disorders apparently constitute a serious health problem .',
  'Sudden sensorineural hearing loss seems to become a serious social health problem in modern societies .',
  'Noise-induced hearing loss ( NIHL ) caused by exposure to high noise levels is a serious socio-economic problem in modern societies .',
  'With rapid urbanization and increase in car ownership , ambient noise pollution resulting from diversified sources ( e.g. , road traffic , railway , commercial services ) has become a severe environmental problem in the populated areas in China .',
  'The Cognitive Behavioral Model of Tinnitus Distress proposes that tinnitus becomes and is maintained as a distressing problem due to a process of interaction between negative thoughts , negative emotions , attention and monitoring , safety behavior , and beliefs .',
  'Introduction \u2003 Noise-induced hearing loss ( NIHL ) is a serious problem for workers and therefore for businesses .',
  'Feedback whistling is a severe problem with hearing aids .',
  'Noise was a serious problem at the majority of workposts of mechanical processing , especially at grinding and deburring ones .',
  'Tinnitus as a symptom remains a serious multidisciplinary problem .',
  'Deafness is a hidden handicap in infancy although lack of vestibular function may delay motor milestones like sitting and walking but does not constitute a serious problem after they are achieved .',
  'Given that by 2018 , more than 400 million people worldwide were suffering from disabling hearing loss and that about one-third involved noise over-exposure , which represents more than 100 million people , this hearing impairment represents a serious health problem .',
  'Inter-floor noise is a severe social problem which causes illegal arson , violence , and even murder .',
  'A worrisome problem exists with the timely intervention in hearing-impaired indigent neonates .',
  'Masking from background noise is often a serious problem when hearing levels are measured at or near the low reference threshold levels specified in the American National Standards Specifications for Audiometers , ANSI S3.6 - 1969 .',
  'Hearing loss is a serious problem with farmers , and yet many farmers neglect to protect their hearing with the use of protection .',
  'A troublesome problem for some of these individuals is the retention of their male voice .',
  'Noise is now recognized as a serious health problem in our modern societies .',
  'This poses a serious problem for the investigator who wants to perform research on music with hearing impaired individuals who wear hearing aids .',
  'In Poland , the diseases of the vocal organ poses a serious problem from the medical and socio-economic points of view .',
  'The production of sweat in the temporal skin region may be a serious problem for patients with hearing aids , active middle ear implants or cochlear implants .',
  'In such cases , the noise from the system itself , such as motors , gears , and engines , namely internal noise , often becomes a troublesome problem .',
  'Hearing loss is a serious occupational health problem worldwide .',
  'For example , despite an overall satisfaction with many aspects of the voice in more than three-quarters of the patients , speaking in a noisy environment was reported by 63 % of the patients as being a serious problem , and a significant relation could be established between pulmonary and voicing problems ( r = 0.28 , P < 0.05 ) , something also undetectable with the EORTC questionnaires .',
  'Pulsatile tinnitus can often present a serious diagnostic problem .',
  'Congenital amusia , characterized by a severe problem in detecting anomalies in melodies , is a lifelong disorder that has been ascribed to an acoustical pitch deficit .',
  'In open-cast mines , noise pollution has become a serious concern due to the extreme use of heavy earth moving machinery ( HEMM ) .',
  'The threat of noise-induced hearing loss is a serious concern for many workers .',
  'congenital hearing loss is a serious health problem affecting 1 to 3 out of 1000 neonates , and is the most common cause of neurosensorial defect ; hearing screening helps to identifying early permanent childhood hearing loss ( HL ) .'],
 'noise': ['It is believed that poor classroom acoustics leads to lower levels of student learning and exposes teachers vocal folds to greater physical wear and tear',
  'One limitation , in most current digital hearing instruments with 16-bit analog-to-digital ( A/D ) converters , is that the compressor before the A/D conversion is limited to 95 dB ( SPL ) or less at the input .',
  'The problem with this postulate is that the electrical source and mechanical load for the electromechanical outer hair cell might be severely attenuated and phase-shifted by the electrical impedance of the cell and the mechanical impedance of the organ of Corti , respectively .',
  'A significant problem with automatic detectors is that they tend to partially detect whistles or break whistles into several parts .',
  'This study although provides evidence that air traffic noise is a serious cause of concern .',
  'Noise-induced hearing loss ( NIHL ) is a serious health concern and prevention of hair cell death or therapeutic intervention at the early stage of NIHL is critical to preserve hearing .',
  'Voice disorders constitute a serious health problem for teachers .',
  'Permanent childhood hearing impairment is a serious public health problem .',
  'Further , most participants were still not aware of the risk of NIHL to them from exposure to excessive noise during matches and did not consider hearing loss from noise exposure during soccer matches a serious concern both before and after the tournament .',
  'The low-pass characteristic of the outer hair cell ( OHC ) voltage response to mechanical stimulation could be considered a serious problem for cochlear models aiming at explaining high-frequency active amplification by introducing instantaneous nonlinear terms because active gain would dramatically decrease at high frequency .',
  'Excessive noise exposure is a serious global urban health problem , adversely affecting millions of people .',
  "High noise levels have been recognized as a serious problem in hospital environments during both night- and daytime , and have been associated with a negative impact on patients ' health status .",
  'Sensorineural hearing loss ( SNHL ) is a serious public health problem which affects 1 - 3 % per hundred live born babies in developed countries .',
  'This document is intended to inform the practice of hearing care professionals who are involved in the audiological management of adults with a severe to profound degree of hearing loss and will highlight the special considerations and practices required to optimize outcomes for these individuals .',
  'These findings suggest that acculturative stress is a serious concern among deaf undergraduate students and that the SAFE-D can be used to assess deaf acculturative stress in this population .',
  'Hearing loss from occupational exposures is a serious and widespread problem .',
  'Hearing loss is the most common sensory deficit in the elderly , and it is becoming a severe social and health problem .',
  'Noise induced hearing loss ( NIHL ) remains as a severe health problem worldwide .',
  '2 . Hearing loss is a serious health problem among the elderly .',
  'Ninety-five per cent of the respondents were aware that loud noise could damage their hearing , 90 % considered that a hearing loss would be a serious problem , and 85 % believed that HPDs could protect their hearing .',
  'Noise pollution is a severe public health problem as continuous exposure to even moderate noise levels between 55 - 65 dB can lead to various pathologies , including neurological states .',
  'Tinnitus , which is a distressing problem affecting many people around the world , is commonly referred to as ringing in the ears .',
  'The effect of acute noise on cognitive function has long been a topic of study , yet these effects remain a serious problem for learning performance in school children .',
  'The gap between the technology supported by policy and the technologies currently being used by deaf and hard of hearing people has become a serious problem that is difficult to solve because of the separate jurisdictions of the two agencies , the need for coordination within the FCC , technological challenges , and funding issues .',
  'Exposure to continuous loud noise is a serious health problem due to excess production of oxygen free radicals .',
  'A troublesome problem for some of these individuals is the retention of a male voice .',
  'Noise pollution in urban cities is a serious problem and steadily increasing over the years .',
  "Since noise was first recognized as a serious environmental pollutant , a number of social surveys have been conducted in order to assess the magnitude of the problem and to develop suitable noise ratings , such that , from a measurement of certain physical characteristics of community noise , one could reliably predict the community 's subjective response to the noise .",
  'Tinnitus is defined as a sound in the ear(s ) and/or head without external origin and is a serious health concern for millions worldwide .',
  'However , an MPO that is too low , as in the cases to avoid discomfort for people with a severe loudness tolerance problem and hearing losses that exceed the fitting range of the hearing aids , could negatively affect sound quality and speech intelligibility in noise .',
  'Hearing loss is a serious problem in infants and children because it may interfere with the development of typical speech , verbal language , and auditory and communication skills .',
  'Impaired hearing is a serious problem .',
  'Idiopathic sudden sensorineural hearing loss ( ISSNHL ) is a vexing problem that continues to pose a diagnostic and therapeutic enigma for the otologist .',
  'Sleep disturbance induced by night-time noise is a serious environmental problem that can cause adverse health effects , such as hypertension and ischemic heart disease .',
  'Hearing loss is the most common sensory deficit in the elderly , and is becoming a severe social and health problem .',
  'Noise pollution is recognized as a serious human health problem in modern society .',
  'With a prevalence of 5 in 1000 newborns with a hearing disorder , the congenital hearing disorders apparently constitute a serious health problem .',
  'Sudden sensorineural hearing loss seems to become a serious social health problem in modern societies .',
  'Noise-induced hearing loss ( NIHL ) caused by exposure to high noise levels is a serious socio-economic problem in modern societies .',
  'With rapid urbanization and increase in car ownership , ambient noise pollution resulting from diversified sources ( e.g. , road traffic , railway , commercial services ) has become a severe environmental problem in the populated areas in China .',
  'The Cognitive Behavioral Model of Tinnitus Distress proposes that tinnitus becomes and is maintained as a distressing problem due to a process of interaction between negative thoughts , negative emotions , attention and monitoring , safety behavior , and beliefs .',
  'Introduction \u2003 Noise-induced hearing loss ( NIHL ) is a serious problem for workers and therefore for businesses .',
  'Feedback whistling is a severe problem with hearing aids .',
  'Noise was a serious problem at the majority of workposts of mechanical processing , especially at grinding and deburring ones .',
  'Tinnitus as a symptom remains a serious multidisciplinary problem .',
  'Deafness is a hidden handicap in infancy although lack of vestibular function may delay motor milestones like sitting and walking but does not constitute a serious problem after they are achieved .',
  'Given that by 2018 , more than 400 million people worldwide were suffering from disabling hearing loss and that about one-third involved noise over-exposure , which represents more than 100 million people , this hearing impairment represents a serious health problem .',
  'Inter-floor noise is a severe social problem which causes illegal arson , violence , and even murder .',
  'A worrisome problem exists with the timely intervention in hearing-impaired indigent neonates .',
  'Masking from background noise is often a serious problem when hearing levels are measured at or near the low reference threshold levels specified in the American National Standards Specifications for Audiometers , ANSI S3.6 - 1969 .',
  'Hearing loss is a serious problem with farmers , and yet many farmers neglect to protect their hearing with the use of protection .',
  'A troublesome problem for some of these individuals is the retention of their male voice .',
  'Noise is now recognized as a serious health problem in our modern societies .',
  'This poses a serious problem for the investigator who wants to perform research on music with hearing impaired individuals who wear hearing aids .',
  'In Poland , the diseases of the vocal organ poses a serious problem from the medical and socio-economic points of view .',
  'The production of sweat in the temporal skin region may be a serious problem for patients with hearing aids , active middle ear implants or cochlear implants .',
  'In such cases , the noise from the system itself , such as motors , gears , and engines , namely internal noise , often becomes a troublesome problem .',
  'Hearing loss is a serious occupational health problem worldwide .',
  'For example , despite an overall satisfaction with many aspects of the voice in more than three-quarters of the patients , speaking in a noisy environment was reported by 63 % of the patients as being a serious problem , and a significant relation could be established between pulmonary and voicing problems ( r = 0.28 , P < 0.05 ) , something also undetectable with the EORTC questionnaires .',
  'Pulsatile tinnitus can often present a serious diagnostic problem .',
  'Congenital amusia , characterized by a severe problem in detecting anomalies in melodies , is a lifelong disorder that has been ascribed to an acoustical pitch deficit .',
  'In open-cast mines , noise pollution has become a serious concern due to the extreme use of heavy earth moving machinery ( HEMM ) .',
  'The threat of noise-induced hearing loss is a serious concern for many workers .',
  'congenital hearing loss is a serious health problem affecting 1 to 3 out of 1000 neonates , and is the most common cause of neurosensorial defect ; hearing screening helps to identifying early permanent childhood hearing loss ( HL ) .'],
 'peritoneal': ['Mesenterial and peritoneal inflammation represents a\xa0major clinical challenge regarding differential diagnosis',
  'A major drawback of continuous ambulatory peritoneal dialysis ( CAPD ) is the occurrence of peritoneal infection .',
  'Susceptibility to bacterial infections in the peritoneal cavity is a serious problem for peritoneal dialysis patients .',
  'In addition , opportunistic infection has become a serious peritonitis problem .',
  'Escherichia coli peritonitis in patients undergoing peritoneal dialysis : a serious problem that may get worse .',
  'Peritonitis is a serious problem in children receiving peritoneal dialysis .',
  'Gene therapy is expected to be used for the treatment of peritoneal fibrosis , which is a serious problem associated with long-term peritoneal dialysis .',
  'Peritonitis is still a serious problem in peritoneal dialysis ( PD ) patients and is associated with mortality .',
  'Renal and perinephric space infection continues to be a serious urological problem with high mortality rate .',
  'By a diet rich in protein and careful use of the peritoneal dialysis catheter the most dangerous complications of the peritoneal dialysis , loss of protein and peritonitis , did not represent a serious problem .',
  'Peritoneal fibrosis ( PF ) , a serious problem in long-term continuous ambulatory peritoneal dialysis ( CAPD ) patients , is characterized by extracellular matrix ( ECM ) accumulation which results from an imbalance between the synthesis and the degradation of ECM components .',
  'Peritonitis remains a serious problem in peritoneal dialysis patients accounting for technique failure and contributing to mortality .',
  'Fibrosis of the peritoneal cavity remains a serious , life-threatening problem in the treatment of kidney failure with peritoneal dialysis .',
  'Microbial contamination of dialysis fluid is a serious problem in therapy .',
  'Peritonitis is a serious and common problem in the peritoneal dialysis ( PD ) population .',
  'Nevertheless peritonitis remains a serious problem and the long-term metabolic effects of CAPD are unknown .',
  'Since peritonitis remains a serious clinical problem , we have evaluated the prophylactic efficacy of intraperitoneally administered chemotactic substances in murine intraperitoneal infections .',
  "In this Practice Point commentary , we discuss Wiggins et al. 's systematic review of the treatment of peritonitis , a serious problem in peritoneal dialysis patients ."],
 'dialysis': ['Mesenterial and peritoneal inflammation represents a\xa0major clinical challenge regarding differential diagnosis',
  'The recirculation of previously dialyzed blood in the lumen of the single-needle catheter reduces dialysis efficiency and is a drawback of single-needle dialysis .',
  'A major drawback of continuous ambulatory peritoneal dialysis ( CAPD ) is the occurrence of peritoneal infection .',
  'Postdialytic rebound ( PDR ) of plasma solutes is a relevant drawback of intermittent hemodialysis , but its pathophysiological process remains undefined .',
  'Susceptibility to bacterial infections in the peritoneal cavity is a serious problem for peritoneal dialysis patients .',
  'Postprandial hypotension during hemodialysis is a serious problem .',
  'Repeated pain during haemodialysis access cannulations is a serious problem for haemodialysis patients even when prescribed oral or topical analgesics .',
  "Degradation of dialysis efficiency during hemodialysis , caused by incompatible indwelling needle size or increase in hematocrit , is a serious problem that can threaten a patient 's life .",
  'SVCS constitutes a serious clinical problem and often represents a definitive loss of vascular access for haemodialysis ( HD ) .',
  'In addition , opportunistic infection has become a serious peritonitis problem .',
  'Vascular access dysfunction is a serious problem in dialysis units .',
  'Aluminum ( Al ) accumulation in bone is a serious problem in patients on hemodialysis .',
  'The occurrence of thrombosis in the vascular access is a serious problem that may severely compromise or even make the hemodialysis impossible , which is vital for the patient .',
  'Secondary hyperparathyroidism remains a serious problem in hemodialysis patients .',
  'Escherichia coli peritonitis in patients undergoing peritoneal dialysis : a serious problem that may get worse .',
  'Peritonitis is a serious problem in children receiving peritoneal dialysis .',
  'Gene therapy is expected to be used for the treatment of peritoneal fibrosis , which is a serious problem associated with long-term peritoneal dialysis .',
  'Peritonitis is still a serious problem in peritoneal dialysis ( PD ) patients and is associated with mortality .',
  'However , in conjunction with disturbances in serum phosphate , Ca , and CaxP product , hyperparathyroidism has become a serious problem in the cardiovascular diseases of patients with end-stage renal disease-even patients undergoing CAPD .',
  'Renal and perinephric space infection continues to be a serious urological problem with high mortality rate .',
  'Vascular access thrombosis represents a serious and common problem in hemodialysis patients .',
  'Vascular access thrombosis represents a serious and unfortunately common problem in hemodialysis patients .',
  'Arteriovenous fistula puncture pain is a serious problem for patients undergoing dialysis and a good indication for topical anesthetics .',
  'By a diet rich in protein and careful use of the peritoneal dialysis catheter the most dangerous complications of the peritoneal dialysis , loss of protein and peritonitis , did not represent a serious problem .',
  'Peritoneal fibrosis ( PF ) , a serious problem in long-term continuous ambulatory peritoneal dialysis ( CAPD ) patients , is characterized by extracellular matrix ( ECM ) accumulation which results from an imbalance between the synthesis and the degradation of ECM components .',
  'Thromboembolic obstruction of the renal artery is a serious clinical problem , but rarely diagnosed .',
  'Peritonitis remains a serious problem in peritoneal dialysis patients accounting for technique failure and contributing to mortality .',
  'This can cause hypovolemia-induced hypotension , a serious problem in the daily practice of hemodialysis : during one out of three sessions a hypotensive episode occurs .',
  'Fibrosis of the peritoneal cavity remains a serious , life-threatening problem in the treatment of kidney failure with peritoneal dialysis .',
  'Microbial contamination of dialysis fluid is a serious problem in therapy .',
  'Peritonitis is a serious and common problem in the peritoneal dialysis ( PD ) population .',
  'Nevertheless peritonitis remains a serious problem and the long-term metabolic effects of CAPD are unknown .',
  'Orthostatic hypotension is a serious problem in patients with diabetes mellitus ( DM ) undergoing hemodialysis ( HD ) .',
  'Vascular access thrombosis represents a serious problem in haemodialysis patients .',
  'Since peritonitis remains a serious clinical problem , we have evaluated the prophylactic efficacy of intraperitoneally administered chemotactic substances in murine intraperitoneal infections .',
  "In this Practice Point commentary , we discuss Wiggins et al. 's systematic review of the treatment of peritonitis , a serious problem in peritoneal dialysis patients ."],
 'peritonitis': ['Mesenterial and peritoneal inflammation represents a\xa0major clinical challenge regarding differential diagnosis',
  'A major drawback of continuous ambulatory peritoneal dialysis ( CAPD ) is the occurrence of peritoneal infection .',
  'Susceptibility to bacterial infections in the peritoneal cavity is a serious problem for peritoneal dialysis patients .',
  'In addition , opportunistic infection has become a serious peritonitis problem .',
  'Escherichia coli peritonitis in patients undergoing peritoneal dialysis : a serious problem that may get worse .',
  'Peritonitis is a serious problem in children receiving peritoneal dialysis .',
  'Gene therapy is expected to be used for the treatment of peritoneal fibrosis , which is a serious problem associated with long-term peritoneal dialysis .',
  'Peritonitis is still a serious problem in peritoneal dialysis ( PD ) patients and is associated with mortality .',
  'Renal and perinephric space infection continues to be a serious urological problem with high mortality rate .',
  'By a diet rich in protein and careful use of the peritoneal dialysis catheter the most dangerous complications of the peritoneal dialysis , loss of protein and peritonitis , did not represent a serious problem .',
  'Peritoneal fibrosis ( PF ) , a serious problem in long-term continuous ambulatory peritoneal dialysis ( CAPD ) patients , is characterized by extracellular matrix ( ECM ) accumulation which results from an imbalance between the synthesis and the degradation of ECM components .',
  'Peritonitis remains a serious problem in peritoneal dialysis patients accounting for technique failure and contributing to mortality .',
  'Fibrosis of the peritoneal cavity remains a serious , life-threatening problem in the treatment of kidney failure with peritoneal dialysis .',
  'Microbial contamination of dialysis fluid is a serious problem in therapy .',
  'Peritonitis is a serious and common problem in the peritoneal dialysis ( PD ) population .',
  'Nevertheless peritonitis remains a serious problem and the long-term metabolic effects of CAPD are unknown .',
  'Since peritonitis remains a serious clinical problem , we have evaluated the prophylactic efficacy of intraperitoneally administered chemotactic substances in murine intraperitoneal infections .',
  "In this Practice Point commentary , we discuss Wiggins et al. 's systematic review of the treatment of peritonitis , a serious problem in peritoneal dialysis patients ."],
 'caries': ['Dental caries has continued to be the major oral disease in the past, as well as the present scenario',
  'Dental caries and periodontal disease are the most common oral diseases',
  'Caries is a serious health problem affecting the Polish population , mostly due to a low level of health awareness , which is reflected in irregular check-ups and a tendency for patients to visit the dentist only when they are already experiencing pain .',
  'IFC is a serious and expensive dental health problem affecting about five per cent of children in Simcoe County .',
  'Although South African studies are limited and most of them relied on self-reports , which could have resulted in a serious overestimation of compliance , even these studies indicate serious shortcomings with regard to infection control practices in oral health care facilities in this country .',
  "The absence of an oral practitioner is a serious problem and can reduce the patient 's chances of cure .",
  'Oral diseases are a serious public health problem , which affects the overall health of a person .',
  'Early childhood caries ( ECC ) is a serious problem that progresses rapidly and often goes untreated .',
  'Since caries represents a serious public health problem in Kosovo , an overall preventive programme for oral health promotion is needed , including the oral health education of mothers .',
  '[ A serious chewing gum problem ] .',
  'Early Childhood Caries ( ECC ) is a serious public health problem in developed as well as developing nations , with high prevalence among children around the world .',
  'Dental disease is still a serious health problem universally possibly because dental health awareness and dental service utilization is still very low .',
  'However , caries continues to be a problem for the lower socioeconomic strata , even in affluent countries , and is a serious problem in developing countries .',
  'Streptococcus mutans is a major etiologic agent of dental caries , a prevalent worldwide infectious disease and a serious public health concern .',
  'It was concluded that , while changes in feeding methods in recent decades have arguably improved pet health by reducing or preventing diseases associated with nutritional deficiencies and excesses , periodontal disease remains a serious , diet-related problem .',
  'Although the prevalence of dental caries is continuing to decline , it still affects a majority of the US population and can be a serious problem for those afflicted .',
  'Although dental decay remains a serious problem in the migrant community , the migrant health centers appear to be making a positive impact on the dental health of the children .',
  'With progressive urbanization and changes in diet and eating habits , consumption of refined sugars is rising steeply ( Table II ) and dental caries has become a serious problem particularly in children from high socioeconomic homes .',
  'Dental caries is a serious public health concern .',
  'Erosion is not a serious problem for dental heath in Chinese preschool children .',
  "Great treatment needs and caries prevalence in permanent first molars in Mashhad schoolchildren show that dental caries is still a serious problem in the children of our society ; therefore , education of parents and teachers is necessary for promoting children 's oral health .",
  'According to National Oral Health Survey reports and research , Early Childhood Caries has been identified as a serious public health problem in Sri Lanka .',
  'Dental caries remains a serious problem due to its detrimental effects on individual health and quality of life .',
  'We concluded that although there was considerable neglect of root caries , particularly among blacks , it was not a serious problem among older North Carolinians .',
  'Early childhood caries ( ECC ) remains a serious problem in several developing and developed countries .',
  'However , the high percentage of inactive licensed dentists in Mexico points to a serious problem .',
  'Early childhood caries is a preventable disease of multifactorial etiology and is a public health problem affecting majority of the preschool-age children of the country .',
  'Early childhood caries ( ECC ) has become a serious medical problem worldwide in the last decade .',
  'Coronary atherosclerosis and periodontal disease , due to their prevalence , are a serious epidemiological problem .',
  'Periodontal disease is a serious oral health problem that is observed in patients with diabetes mellitus .',
  'Poor oral health was flagged as a severe public health problem .',
  'Although tooth loss is a serious health problem for elderly people , little is known about the genetic basis for susceptibility to it .',
  'Baby bottle tooth decay : a preventable health problem in infants .',
  'Early childhood caries ( ECC ) is a serious public health problem in China .',
  'Early childhood caries ( ECC ) is a serious problem that has remained unexplored in sub-Saharan Africa .',
  'Our results confirmed that malocclusion has become a serious oral health problem in Chinese schoolchildren , highlighting the need for proactive interventions at an early age .',
  'The high rates of preventable dental disease in Aboriginal communities are a serious concern from a social standpoint and in terms of service provision and health care expenditure .',
  'Early childhood caries ( ECC ) represents a serious problem in pediatric dentistry .',
  'Early childhood caries ( ECC ) is a serious public health problem in disadvantaged communities in both developing and industrialized countries in which under-nutrition is common .',
  'These results suggest a serious access problem and one that ultimately produces even worse oral health and expensive major procedures for this population in the future .',
  'Chronic oral malodor is a serious concern for about one-fifth of the North American population , and a field of emerging research interest .',
  'Although malocclusions represent a serious public health issue , there is insufficient information about this problem in adolescents in Brazil , especially in poorer areas .',
  'At the end of the 19th century dental caries had become a serious health problem in many countries , especially among children and young people .',
  'Inflammatory periodontal diseases represent a serious dental and general medical problem due to the high prevalence among the adult population , the presence of clinical forms leading to the destruction of the dentition and tooth loss , insufficient treatment effectiveness and the frequency of relapse , including in connection with the formation of biofilms .',
  'Approximately 70 percent have been found to be in urgent need of dental care , a serious problem because many Allston-Brighton parents can not afford to pay for such care .',
  'Secondary caries continuous to be a serious problem although amalgam has been improved to a large extent .',
  'It was concluded from this study that few teeth had been lost during the 5-year period but that dental caries still appeared to be a serious problem among some very elderly people .',
  'Early childhood caries ( ECC ) was a serious oral health concern with high prevalence and a low treatment rate in China , and few researches have focused on preschool children .',
  'The chronic cumulative nature of caries makes treatment needs a severe problem in adults .',
  'Many GUMs available in Indonesia claim to offer nutritional benefits ; however , the current levels of sugar content in GUMs are a serious concern and are inappropriate for inclusion in the diets of young children .',
  'Caries is a social disease and a serious problem , especially in the childhood .',
  'The current data available on the dmft and DMFT indicate that childhood dental caries is still a serious dental public health problem in the UAE that warrants immediate attention by the government and policy makers .',
  'The lack of reliable and recent information about the oral and dental health conditions of many African countries is a serious object of concern .',
  'Although filling a gap in service provision for poor populations , illegal provision of oral care is a serious public health problem , resulting in situations of low-quality care and risks for patients .',
  'Cambodian preschool children have a severe burden of dental caries and a high proportion of families are impacted by this problem .',
  'Early childhood caries ( ECC ) is a serious problem in China .',
  'Dental caries or tooth decay is a preventable and multifactorial disease that affects billions of people globally and is a particular concern in younger populations .',
  'Early childhood caries ( ECC ) is a serious public health problem in both developing and industrialized countries .',
  'Tongue biting in infants has a variety of aetiological factors and is a distressing problem .',
  'Access to oral health care for people living with HIV/AIDS is a severe problem .',
  'I have always done my best with my teeth , including flossing three times a day , but still have a serious problem with gum recession and have lost a few teeth .',
  'Clearly , fluoride has raised the threshold of sugar intake at which caries will progress to cavitation , but fluoride has its limits , and caries remains a serious problem for disadvantaged individuals in many industrialized countries and is a rising problem in many developing countries .',
  'Early childhood caries , a serious health problem among young children , can be prevented with effective intervention .',
  'Access to quality dental care for many adults and children remains a serious concern .',
  'Dental caries is a diet-associated disease which continues to be a serious health problem in most industrialized and developing countries .',
  'The aim of the work was to determine the relationship between the level of HCHO and the levels of its generators in pathologically changed teeth , mainly carietic teeth as tooth caries is still a serious and commonly occurring problem .',
  'Dental caries still constitutes a serious health problem in Łódzkie voivodeship .',
  'Early childhood caries in preschool children of Kosovo - a serious public health problem .',
  'Dental caries ( decay ) is a serious problem for young Aboriginal children , causing pain and stress .',
  'Lack of access to oral care is a severe problem in the United States with over one-third of the population lacking dental insurance .',
  'Childhood dental caries is a serious dental public health problem that warrants the immediate attention of the government and the dental profession officials in Saudi Arabia .',
  'The view that periodontal diseases are a much more prevalent and a severe problem in the developing countries seems to be true only in terms of poorer oral hygiene and considerably greater calculus retention , already at a young age , but not so clear for periodontal destruction in adults .'],
 'adolescent': ['One barrier to effectively treating weight issues among adolescents is that they tend to use social comparison instead of objective measures to evaluate their own health status',
  'Adolescent obesity is a serious public health concern .',
  'Substance use ( SU ) problems are common among adolescents , a serious health risk for them and a major public health problem , but are inadequately addressed in most pediatric health care settings .',
  'Substance use among college students in Iran is a serious problem . Determining the pattern of substance use among University students is an important issue for implementing prevention and treatment programs .',
  'Drug or substance abuse by adolescents continues to have a major impact on the health and well-being of young people and poses a serious management problem for health workers .',
  'Drug addiction , particularly among teenagers and young adults , has become a serious public health problem globally .',
  'Obesity is a serious health problem for all age groups , particularly adolescents ; therefore , it is important for adolescents to develop healthy nutrition habits and acquire exercise behaviours .',
  'Substance use in European adolescents remains a serious health concern .',
  'NMUPD is a serious concern among adolescents and emerging adults .',
  'Adolescent substance use ( SU ) remains a serious problem .',
  'Substance abuse by adolescents is a serious problem that will touch every orthodontic practice .',
  'Low participation rates constitute a serious problem faced by family drug abuse prevention programs .',
  'While drug abuse among adolescents and young adults has begun to decline from the epidemic levels of the late 1970s , it remains a serious national health problem .',
  'The average value of BMI has increased over time ; overweight and obesity among adolescents has become a serious public health problem .',
  'Adolescent substance abuse is a serious problem in Hong Kong .',
  'Substance abuse is a serious problem in the young adult population , yet there exists a lack of reliable screening measures for use in identifying problem users in this age group .',
  'The increasing prevalence of obesity in children and adolescents is a serious public health concern .',
  'Concurrent mental health and substance use issues are a serious problem for adolescents and transition-aged youth .',
  'Adolescent substance abuse is a serious public health concern , and in response to this problem , a number of effective treatment approaches have been developed .',
  'Adolescent substance use has become a serious concern nationwide .',
  'Substance use among adolescents is a serious problem worldwide .',
  'Even among a population of middle-class adolescents having follow-up in a suburban pediatric practice , use of marijuana and other drugs may constitute a serious health and psychologic problem .',
  'Organic solvent abuse in adolescents has become a serious social problem .',
  'Consumption of junk food among adolescents has been recognized as a serious health problem in the world .',
  'The prevalence of adolescent obesity has increased dramatically , becoming a serious public health concern .',
  'Adolescent substance use disorder ( SUD ) is a serious public health concern .',
  'Substance use disorders are a serious public health concern that affect approximately one in 12 individuals 12 years and older .',
  'Adolescent substance abuse is a serious and growing problem worldwide .',
  'Adolescent drug and alcohol addiction is a serious problem in the United States .',
  'The prevalence of adolescent obesity has increased considerably over the past decade in Switzerland and has become a serious public health problem in Europe .',
  'The use of tobacco , alcohol and psychoactive substances in a society , also by very young consumers , currently poses a serious social problem .',
  'The use of alcohol and drugs amongst young people is a serious concern and the need for effective prevention is clear .',
  'Adolescent substance abuse is a serious social problem facing the United States .',
  'Substance use by adolescents and young adults continues to be a serious problem .',
  'Substance abuse among young people has become a serious public health problem for years .',
  'Adolescent obesity is a serious health problem associated with many comorbidities .',
  'Extreme obesity among U.S. adolescents is a serious problem and has disproportionally affected ethnic minorities .',
  'Substance use among Mexican origin , low-income youths is a serious , but under-studied problem .',
  'The Code Blue report , recently issued by a distinguished panel formed by national medical and educational associations , paints a dire picture of the state of adolescent health and recommends far-reaching measures to reverse " dangerous trends . " However , analysis of the report \'s findings reveals serious flaws in its presentation of nearly every youth problem cited , and its recommendations are much less original and workable than portrayed .',
  'Unhealthy eating behavior is a serious health concern among secondary school students in Inner Mongolia .',
  'The prevalence of obesity , a serious public health problem , is increasing among teenagers and thus also increases cardiovascular morbidity and mortality in adulthood .',
  'The concurrent or sequential usage of multiple substances during adolescence is a serious public health problem .',
  'The use of psychotropic substances in adolescents represents a serious public health problem .',
  'Psychoactive substances use among adolescents is a serious public health problem , as it exposes them to risks and health hazards and can ultimately lead to dependence .',
  'Student substance abuse is a serious concern for middle school personnel .',
  'Alcohol and other drug use among adolescents is a serious concern , and effective prevention is critical .',
  'Rising youth obesity is a serious public health concern .',
  'Findings confirmed psychopathologic conditions as a serious health concern in obese and morbidly obese adolescents .',
  'Low rates of participation constitute a serious problem for family-based drug-use prevention programs .',
  'Adolescent obesity continues to be a serious concern around the world , placing young people at risk for chronic conditions and early death .',
  'The eating habits of adolescents are a serious current public health problem .',
  'Compared with other illicit substances , stimulants are not commonly used by adolescents ; however , they represent a serious concern regarding substance use among youths .',
  'Substance use ( smoking , drinking and illicit drug use ) remains , a serious problem for young people living in industrialised countries .',
  'Parental substance abuse is a serious problem affecting the well-being of children and families .',
  'Drug use among adolescents is a serious problem in our society , as some individuals develop dependence and addiction .',
  'Unhealthy weight control behaviors are a serious concern , impairing the quality of life in adolescents .',
  'Adolescent substance abuse is a serious problem for which effective interventions are needed .',
  'Prevalence of obesity among adolescents constitutes a serious public health problem .',
  'Substance use disorders among youth remain a serious public health problem .',
  'Substance use disorder is a serious health problem that tends to manifest in late adolescence .',
  'Several studies have been demonstrated that the adolescent substance abuse is a serious and growing problem .',
  'The average value of BMI and SFT has increased over time ; overweight and obesity among adolescents has become a serious public health problem .',
  'Obesity was found to be a serious health problem in the population of adolescents studied , especially given the high cardiovascular risk that is characteristic of this condition .',
  'Substance abuse in youth is a serious public health problem , with significant morbidity and mortality .',
  'An increase in the obese adolescent population is being recognized as a serious medical and social problem .',
  'Adolescent substance use is a serious problem often invoking negative reactions .'],
 'addiction': ['The behavioral model of health service use identified health needs, service preferences (predispositions), and service availability (enabling factors) as important predictors, but research has not conceptualized consistently each type of influence nor identified their separate effects on use of substance abuse and mental health services or their value in predicting service outcomes',
  'A primary problem with exposure-based interventions for addiction is that after learning not to use substances in the presence of addiction cues inside the clinic ( i.e. , extinction ) , stimuli in the naturalistic setting outside the clinic may continue to elicit craving , drug use , or other maladaptive conditioned responses .',
  'The problem with this is that many of these " symptoms " of drug use are , in the case of SNAP participants , tied to contextual issues of living in the DTES , experiencing structural vulnerability , and being the target of punitive drug policies and laws .',
  'A major drawback of existing health games is that they are not very well described and attributed with ( machine-readable , quantitative , and qualitative ) metadata such as the characterizing goal of the game , the target user group , or expected health effects well proven in scientific studies .',
  'Internet addition disorder ( IAD ) is currently becoming a serious mental health problem among Chinese adolescents .',
  'This is a serious problem in the addiction field , likely to be made worse as new technologies are introduced and/or as there is industry consolidation ( Corredoira , R. , Kimberly , J. ( 2006 ) Industry evolution through consolidation : Implications for addiction treatment .',
  'As excessive use of internet gaming has become a serious public health concern , increasing studies have revealed that impulsivity is one of the important risk factors of internet gaming disorder ( IGD ) .',
  'Drug addiction is a serious health problem prevalent worldwide .',
  'The abuse of drugs has become a serious social problem worldwide .',
  'Use of alcohol and other drugs has been acknowledged as a serious problem among American Indian populations .',
  'Drug dependence , the physical and psychological one after chronic drug administration , is a serious clinical and social problem .',
  'Problematic online game use ( POGU ) has become a serious global public health concern among adolescents .',
  'There is a great deal of medical literature suggesting that substance use disorder is a serious clinical concern , affecting general population and associated with considerable economic , societal , and personal costs .',
  'Substance abuse and dependence is a serious problem throughout the world .',
  'Addiction to intravenously administered drugs has been a serious epidemiological problem for years .',
  'Excessive computer game playing ( ECGP ) has already become a serious social problem .',
  'Patients recovering from substance use disorders are commonly seen in the primary care setting , and relapse is a serious long-term problem for these patients .',
  'Drug addiction is a serious worldwide problem with strong genetic and environmental influences .',
  'Drug and alcohol use presents a serious social problem for most countries in the world .',
  'Substance use disorder is a serious public health problem .',
  'The results of the study are in accordance with our previous findings on Internet use and mental health , confirming that Internet addiction is a potentially a serious public health problem .',
  'Internet addiction among college students has become a serious problem in China .',
  'Internet addiction is a serious problem , and the incidence has increased significantly in recent years .',
  '[ NARCOTIC PRESCRIPTIONS AND THE PROBLEM OF DRUG ADDICTION IN SWEDEN . SHALL THE POLICE TAKE OVER THE ENTIRE MANAGEMENT OF A SERIOUS PROBLEM IN SOCIAL MEDICINE ? ] .',
  'Addiction to psychostimulant drugs such as nicotine , amphetamine , and cocaine is a serious public health problem for which there is a paucity of accepted forms of pharmacotherapy .',
  'Intravenous drug abuse is a serious medical problem in the United States .',
  'Even though its abuse is a serious problem in many countries , there are few safe and effective therapies to treat addiction .',
  'In summary , substance abuse is a serious problem in America .',
  'CJ-DATS applies implementation science perspectives and methods to address a vexing problem - the need to link offender populations with effective treatment for drug abuse , HIV , and other related conditions for which they are at high risk .',
  'Substance abuse is a serious problem , because it affects both workers and young people .',
  'Internet addiction ( IA ) is currently becoming a serious mental health problem .',
  'Drug abuse is a serious problem causing health , economical and psycho-social negative outcomes .',
  'Abuse of addictive substances is a serious problem that has a significant impact on areas such as health , the economy , and public safety .',
  'Addiction to analgesics and tranquilizers remained a serious problem in these patients even after they were placed on chronic hemodialysis .',
  'Drug addiction is a serious health problem .',
  'Substance use disorder is characterized by repeated use of a substance , leading to clinically significant distress , making it a serious public health concern .',
  'Chemical dependency prevention became a serious concern in the 1970s in response to the rising drug epidemic .',
  "Addiction has surpassed the boundaries of health and treatment and turned into a social crisis and a debilitating and major concern in today 's world .",
  'Drug dependence has been a severe social and health problem , which has caused serious economic losses and social disorder in China .',
  'Drug addiction is a debilitating disorder and its pivotal problem is the high relapse rate .',
  'Psychoactive substance abuse and addiction have increasingly become severe , which are not only a serious social problem , but an important medical problem as well .',
  'Patterns of brain activation induced by drug-paired cues have been identified in human and animal models , but lack of specificity poses a serious problem for craving or relapse interpretations .',
  'Drug abuse is a serious problem associated with different pathological outcomes including modulating the immune system .',
  'Addiction is a serious health problem which leads to general social impairment .',
  'Our findings using data from Washington State , align with existing data and signal a dire need to address alcohol and opioid misuse through targeted interventions to prevent overdose and poisoning , with special considerations for American Indian/Alaska Native communities .',
  'Addictive disorders are a severe health concern .',
  'Drug addiction continues to be a serious medical and social problem .',
  'Internet addiction has become a serious behavioral health problem in Asia .',
  'Internet addiction is a serious problem that can negatively impact both the physical and mental health of individuals .',
  'Drug abuse is a serious problem in Poland , it has expanded in recent years and it is likely to expand further in the years to come .',
  "Intravenous drug use has been a serious problem for Dublin 's deprived inner city areas since the late 1970 's .",
  'Drug abuse is a serious problem in the United States and in the world .',
  'The addictions are common chronic psychiatric diseases which represent a serious worldwide public-health problem .',
  'Infected pseudoaneurysm in intravenous ( IV ) drug abusers is a serious clinical problem , with difficult and controversial management .',
  'Published epidemiological studies in international and domestic journals show that drug use/abuse is a serious mental health problem in Iran .',
  'Substance use disorder ( SUD ) is a serious public health problem worldwide for which available treatments show limited effectiveness .',
  'Hence , we discuss : ( 1 ) why persons with substance use disorders are at increased risk for infection with COVID-19 and a severe illness course ; ( 2 ) anticipated adverse consequences of COVID-19 in persons with substance use disorders ; ( 3 ) challenges to health care delivery and substance use treatment programs during and after the COVID-19 pandemic ; and ( 4 ) the potential impact on clinical research in substance use disorders .',
  'Drug addiction is a serious problem worldwide .',
  'Drug abuse is a serious problem worldwide .',
  'The number of internet users is increasing rapidly and internet addiction among adolescents has become a serious public health problem in Korea .',
  'Addiction is a serious and prevalent problem across the globe .',
  'Recreational drug abuse represents a serious public health problem .',
  'Drug overuse is a serious problem for health care , and one of the biggest problems for the socio-economic well-being of different communities .',
  'Computer overuse has been a serious problem for the past several years .',
  'Emergence of new addictive substances and progressive increase of \' drug abuse " has become a serious problem in many countries .',
  'Substance abuse in the United States is a serious public health concern impacting morbidity and mortality .',
  'High relapse rate of drug-dependent patients is a serious problem in the current situation .',
  'The early systemic relapse continues to be a serious problem that needs further intervention .',
  'Drug use is a serious public health problem in Greater S o Paulo , and this is shown by the great amount of hospital admissions due to drug addiction .',
  'Widespread use of the internet is a serious concern among university students worldwide .',
  'The co-occurrence of mental and physical disorders related to substance abuse of treated patients is more often a serious problem to medical services .',
  'Internet addiction is a serious problem with a profound impact on mental health .',
  'Drug addiction is a devastating health problem that is a very heavy burden on the individual affected and the society in general .',
  'Concurrent use of alcohol and other drugs is a serious problem .',
  'Substance use disorders ( SUD ) and behavioral addictions are devastating conditions that impose a severe burden on all societies , and represent difficult challenges for clinicians .',
  'Substance use disorders ( SUDs ) are a serious worldwide problem .',
  'Two groups of adult video gamers were identified : those players who did ( N=37 ) and those who did not ( N=80 ) identify as having a serious gaming problem at the initial survey intake .',
  'Internet addiction ( IA ) among adolescents is a serious public health problem around the world .',
  'Drug abuse remains a serious problem in China , and has become a major threat to public health and social security . Since the issuance and enforcement of the new Anti-Drug law in 2008 , the community has become the primary site for drug rehabilitation .',
  'We found high levels of nonrational drug use in the NISSRP system in both 1996 and 1999 , indicating a serious ongoing problem .',
  'Substance abuse is a serious health concern .',
  'Substance use disorder is a serious problem in nursing that is often invisible and not well understood or well handled .',
  'We aimed to examine the effectivity of a guided ICBT combined with a serious gaming intervention in improving self-reported psychophysiological and immunological health endpoints in response to psychophysiological and immune-related challenges .',
  'Substance dependence/addiction , involving both a common brain reward mechanism and longer-lasting molecular and cellular changes , is a preventable chronic , relapsing brain disease and as such a public health problem .',
  'Drug abuse is a serious public health problem .',
  'Water intoxication is a serious problem in many patients with chronic psychiatric illness .',
  'Drug dependence is a serious health and social problem .',
  'Prescription drug abuse in Southwest Virginia is a serious problem affecting indi-viduals , families , and communities .',
  'Substance abuse is a serious global problem that is affected by multiple psychosocial and socio-demographic factors .',
  'The global substance use problem is a serious public health concern that affects not only health , safety and well-being of communities , but also social and economic development .',
  'Deleterious health sequelae caused by licit and illicit substance use is a serious problem in our society .',
  'Drug misuse is a serious public health problem .',
  'Internet addiction ( IA ) , also referred to as Internet use disorder , is a serious problem all over the world , especially in Asian countries .',
  'Psychoactive substance abuse remains a serious problem among anesthesiologists .',
  'Illicit drug abuse is a serious global problem that can only be solved through international cooperation .',
  'Procrastination is seen as a severe problem among young people , and many factors have been claimed to be associated with it , playing video games being one of them .',
  'Work-related problems are a serious concern among persons with substance use but due to lack of a standardized tool to measure it ; these problems are neither systematically assessed nor appropriately addressed .',
  'Substance abuse is a serious concern in the profession of nursing .',
  'Though substance abuse and its deleterious health sequelae are a serious problem in Taiwan , licit and illicit substance use patterns among nurses are understudied .',
  'Drug use among employees continues to be a serious concern for American employers .',
  'Illicit drug use is a serious public health problem associated with significant co-occurring medical disorders , mental disorders , and social problems .',
  'Addictive disorders are a serious health problem to which large amounts of research resources are devoted .',
  'Drug addiction is a chronic brain disease that is a serious social problem and causes enormous financial burden .',
  'Substance abuse remains a serious medical , public health , and social problem .',
  'Drug addiction , a chronic relapsing disorder , is a serious public health problem around the world .',
  'Multiple relapses in patients taking primaquine as prescribed present a serious clinical problem , and understanding the basis of repeated therapeutic failure is a challenging technical problem .',
  'Substance abuse is a serious problem from which , regardless of sex or race , no one is immune .',
  'Intravenous drug use more as a serious problem for today .',
  'MDMA abuse continues being a serious problem in our society .',
  'Many countries including China are facing a serious opiate dependence problem .',
  'Substance abuse in the elderly is a serious problem that is often overlooked .',
  'The spread of these games through the internet and social networks is becoming a serious health problem facing physicians and medical professionals every day , especially in the ED ; for this reason , it is necessary to be aware of the risks represented by such behaviors in order to recognize and identify preliminary symptoms and develop useful prevention programs .',
  'Cummings ( 1979 ) , citing evidence from the National Institute of Drug Abuse , reports that one of every eleven adult Americans suffers from a severe addictive problem .',
  'Using serious games seems to be attractive in order to link between a serious purpose , which is handling a health problem and gaming .',
  'Conversely , perceiving drug dealing or drug use as a serious problem was associated with walking more frequently .',
  'Drug abuse is still a serious problem of nowadays .',
  'Problematic online gaming ( POG ) and problematic Internet use ( PIU ) have become a serious public mental health problem , with Internet gaming disorder ( IGD ) included in " Conditions for further study " section of DSM-5 .'],
 'thrombectomy': ['Although mechanical thrombectomy is a standard endovascular therapy for patients with acute ischemic stroke (AIS), the incidence of and risk factors for contrast-induced nephropathy (CIN) following mechanical thrombectomy are infrequently reported',
  'A major drawback of MSCT consists in the use of contrast dye , which may be unsafe in transcatheter aortic valve implantation ( TAVI ) patients who frequently are affected by renal failure .',
  'Contrast-induced nephropathy ( CIN ) has become a serious problem for patients with pre-existing renal insufficiency undergoing percutaneous coronary intervention ( PCI ) .',
  'Contrast enhanced procedures are performed with increasing frequency and the patients population is progressively older and with multiple co-morbid conditions , thus contrast media toxicity is becoming a serious problem .',
  'The increased elimination of the dye occurring after small doses of various irritants , which is frequently characteristic of the early stages of a severe nephritis , and which is seen also several days after unilateral nephrectomy , would appear to have an important relation to the problem of kidney function ; and although probably not of clinical importance , it is worthy of further study as a phase of renal activity .',
  'Despite the development of new non-ionic low-osmolality contrast media , nephrotoxicity of intravascular radio-opaque contrast media remains a severe clinical problem , particularly in patients with risk factors .',
  'Contrast-induced nephropathy ( CIN ) is a serious clinical problem associated with increased morbidity and mortality , particularly in patients with chronic renal insufficiency .',
  'Contrast-induced acute kidney injury ( CI-AKI ) is a vexing problem , and more than 70 million patients undergo studies using iodinated contrast .',
  'Contrast-induced nephropathy ( CIN ) , caused by a combination of the direct tubular toxicity of contrast media , a reduction in medullary blood flow , and the generation of reactive oxygen species , is a serious clinical problem .',
  'Iodinated contrast media ( ICM ) hypersensitivity reactions represent a serious problem .',
  'The prevention of contrast-induced nephropathy , which accounts for considerable morbidity and mortality , remains a vexing problem .',
  'The nephrotoxicity induced by contrast media remains a serious clinical problem , and the underlying mechanism has not been completely understood .'],
 'delirium': ['Delirium affects approximately 1 in 4 patients during their hospitalization and is associated with numerous complications',
  'The problem with these studies is that prevalence rates of delirium could only be estimated because of the lack of validated delirium assessment tools for the paediatric intensive care unit ( PICU ) .',
  'Delirium , defined as an acute , fluctuating disorder of attention and cognition , is a serious and increasingly common problem for hospitalized older persons .',
  'Delirium is a serious problem when caring for a patient with cancer in the hospital .',
  'Although delirium is considered as a serious problem by a majority of the surveyed ICU professionals , it is still under-recognized in routine critical care practice .',
  'Delirium is a serious and prevalent problem in intensive care units ( ICU ) .',
  'The majority of participants 143 ( 95 % ) recognised delirium as a serious problem and 93 % considered delirium to be an under-diagnosed syndrome that requires active medical intervention .',
  'Delirium is a serious and pervasive problem in the postoperative setting .',
  'Delirium is a serious and common problem in people over 60 \xa0 years of age who are admitted to hospitals .',
  'As delirium in intensive care unit ( ICU ) patients is a serious problem that can result in increased mortality and morbidity , routine delirium assessment of all ICU patients is recommended .',
  'Delirium represents a serious problem that impacts the physical and cognitive prognosis of patients admitted to intensive care units and requires prompt diagnosis and management .',
  'Although ICU professionals consider delirium a serious problem , several important barriers to adhere to guidelines on delirium management are still present today .',
  'Delirium is a serious health problem with significant negative consequences which is experienced by many hospitalized elderly patients .',
  'Delirium is a serious and common problem in severely medically ill patients of all ages .',
  'Delirium is a serious medical problem and recognized as a common syndrome in critically ill children .',
  'In conclusion , most nurses and physicians consider ICU delirium to be a serious problem , but lack knowledge on delirium and monitor this condition poorly .',
  'Delirium is a life-threatening , frequently reversible condition that is often a sign of an underlying health problem .',
  'Delirium is a serious problem with important consequences and can be prevented or improved using the information that we have learned in the last decade .',
  'Delirium is a severe problem among elderly patients in the ICU .',
  'Delirium in the intensive care unit is a serious problem that has recently attracted much attention .',
  'Awareness of the clinical importance of delirium in adults is growing as emerging research demonstrates that delirium represents a serious medical problem with significant sequelae .',
  'Delirium is a serious and prevalent problem that occurs in many hospitalized older adults .',
  'The high incidence of delirium in surgical units is a serious quality concern , given its impact on morbidity and mortality .'],
 'icu': ['Delirium affects approximately 1 in 4 patients during their hospitalization and is associated with numerous complications',
  'The problem with these studies is that prevalence rates of delirium could only be estimated because of the lack of validated delirium assessment tools for the paediatric intensive care unit ( PICU ) .',
  'Delirium , defined as an acute , fluctuating disorder of attention and cognition , is a serious and increasingly common problem for hospitalized older persons .',
  'Delirium is a serious problem when caring for a patient with cancer in the hospital .',
  'Although delirium is considered as a serious problem by a majority of the surveyed ICU professionals , it is still under-recognized in routine critical care practice .',
  'Delirium is a serious and prevalent problem in intensive care units ( ICU ) .',
  'The majority of participants 143 ( 95 % ) recognised delirium as a serious problem and 93 % considered delirium to be an under-diagnosed syndrome that requires active medical intervention .',
  'Delirium is a serious and pervasive problem in the postoperative setting .',
  'Delirium is a serious and common problem in people over 60 \xa0 years of age who are admitted to hospitals .',
  'As delirium in intensive care unit ( ICU ) patients is a serious problem that can result in increased mortality and morbidity , routine delirium assessment of all ICU patients is recommended .',
  'Delirium represents a serious problem that impacts the physical and cognitive prognosis of patients admitted to intensive care units and requires prompt diagnosis and management .',
  'Although ICU professionals consider delirium a serious problem , several important barriers to adhere to guidelines on delirium management are still present today .',
  'Delirium is a serious health problem with significant negative consequences which is experienced by many hospitalized elderly patients .',
  'Delirium is a serious and common problem in severely medically ill patients of all ages .',
  'Delirium is a serious medical problem and recognized as a common syndrome in critically ill children .',
  'In conclusion , most nurses and physicians consider ICU delirium to be a serious problem , but lack knowledge on delirium and monitor this condition poorly .',
  'Delirium is a life-threatening , frequently reversible condition that is often a sign of an underlying health problem .',
  'Delirium is a serious problem with important consequences and can be prevented or improved using the information that we have learned in the last decade .',
  'Delirium is a severe problem among elderly patients in the ICU .',
  'Delirium in the intensive care unit is a serious problem that has recently attracted much attention .',
  'Awareness of the clinical importance of delirium in adults is growing as emerging research demonstrates that delirium represents a serious medical problem with significant sequelae .',
  'Delirium is a serious and prevalent problem that occurs in many hospitalized older adults .',
  'The high incidence of delirium in surgical units is a serious quality concern , given its impact on morbidity and mortality .'],
 'bladder': ['Urothelial carcinoma (UC) is the most common genitourinary malignancy in China',
  'Bladder cancer which invades the muscle is a serious problem which usually requires extensive therapy .',
  'Bladder dysfunction after radical hysterectomy and/or radiotherapy for uterine cancer is a serious problem .',
  'Bladder cancer becomes a serious medical and social concern due to its high recurrence and mortality rates .',
  'The relatively high incidence of recurrence of bladder cancer is a serious problem in clinical practice .',
  'Although superficial bladder cancer can generally be treated successfully , tumor recurrence is a serious clinical problem , with a recurrence rate of approximately 70 % .',
  'Bladder cancer ( BC ) has become a serious public health problem due to its continuously rising incidence , high recurrence rate , and poor quality of life .',
  'Muscle invasive bladder cancer is a serious clinical problem and is fatal for the majority of patients .',
  'Urinary tract infection after radical cystectomy : a vexing problem despite prophylactic antibiotics .',
  'Since a high-rate of recurrence is a serious problem for early stage urothelial carcinomas , new strategies for the management of recurrent urothelial carcinomas have been explored .',
  'Muscle invasive bladder cancer is a serious clinical problem and is fatal for the majority of patients .',
  'The management of high-grade ( HG ) non-muscle-invasive bladder cancer ( NMIBC ) continues to be a serious clinical problem .',
  'Recurrence is a serious problem in patients with bladder cancer .',
  'Bladder cancer ( BC ) is a serious medical problem .',
  'Pelvic recurrence following cystectomy is a devastating problem for both physician and patient .'],
 'urothelial': ['Urothelial carcinoma (UC) is the most common genitourinary malignancy in China',
  'Bladder cancer which invades the muscle is a serious problem which usually requires extensive therapy .',
  'Bladder dysfunction after radical hysterectomy and/or radiotherapy for uterine cancer is a serious problem .',
  'Bladder cancer becomes a serious medical and social concern due to its high recurrence and mortality rates .',
  'The relatively high incidence of recurrence of bladder cancer is a serious problem in clinical practice .',
  'Although superficial bladder cancer can generally be treated successfully , tumor recurrence is a serious clinical problem , with a recurrence rate of approximately 70 % .',
  'Bladder cancer ( BC ) has become a serious public health problem due to its continuously rising incidence , high recurrence rate , and poor quality of life .',
  'Muscle invasive bladder cancer is a serious clinical problem and is fatal for the majority of patients .',
  'Urinary tract infection after radical cystectomy : a vexing problem despite prophylactic antibiotics .',
  'Since a high-rate of recurrence is a serious problem for early stage urothelial carcinomas , new strategies for the management of recurrent urothelial carcinomas have been explored .',
  'Muscle invasive bladder cancer is a serious clinical problem and is fatal for the majority of patients .',
  'The management of high-grade ( HG ) non-muscle-invasive bladder cancer ( NMIBC ) continues to be a serious clinical problem .',
  'Recurrence is a serious problem in patients with bladder cancer .',
  'Bladder cancer ( BC ) is a serious medical problem .',
  'Pelvic recurrence following cystectomy is a devastating problem for both physician and patient .'],
 'cystectomy': ['Urothelial carcinoma (UC) is the most common genitourinary malignancy in China',
  'Bladder cancer which invades the muscle is a serious problem which usually requires extensive therapy .',
  'Bladder dysfunction after radical hysterectomy and/or radiotherapy for uterine cancer is a serious problem .',
  'Bladder cancer becomes a serious medical and social concern due to its high recurrence and mortality rates .',
  'The relatively high incidence of recurrence of bladder cancer is a serious problem in clinical practice .',
  'Although superficial bladder cancer can generally be treated successfully , tumor recurrence is a serious clinical problem , with a recurrence rate of approximately 70 % .',
  'Bladder cancer ( BC ) has become a serious public health problem due to its continuously rising incidence , high recurrence rate , and poor quality of life .',
  'Muscle invasive bladder cancer is a serious clinical problem and is fatal for the majority of patients .',
  'Urinary tract infection after radical cystectomy : a vexing problem despite prophylactic antibiotics .',
  'Since a high-rate of recurrence is a serious problem for early stage urothelial carcinomas , new strategies for the management of recurrent urothelial carcinomas have been explored .',
  'Muscle invasive bladder cancer is a serious clinical problem and is fatal for the majority of patients .',
  'The management of high-grade ( HG ) non-muscle-invasive bladder cancer ( NMIBC ) continues to be a serious clinical problem .',
  'Recurrence is a serious problem in patients with bladder cancer .',
  'Bladder cancer ( BC ) is a serious medical problem .',
  'Pelvic recurrence following cystectomy is a devastating problem for both physician and patient .'],
 'carcinomas': ['Urothelial carcinoma (UC) is the most common genitourinary malignancy in China',
  'Bladder cancer which invades the muscle is a serious problem which usually requires extensive therapy .',
  'Bladder dysfunction after radical hysterectomy and/or radiotherapy for uterine cancer is a serious problem .',
  'Bladder cancer becomes a serious medical and social concern due to its high recurrence and mortality rates .',
  'The relatively high incidence of recurrence of bladder cancer is a serious problem in clinical practice .',
  'Although superficial bladder cancer can generally be treated successfully , tumor recurrence is a serious clinical problem , with a recurrence rate of approximately 70 % .',
  'Bladder cancer ( BC ) has become a serious public health problem due to its continuously rising incidence , high recurrence rate , and poor quality of life .',
  'Muscle invasive bladder cancer is a serious clinical problem and is fatal for the majority of patients .',
  'Urinary tract infection after radical cystectomy : a vexing problem despite prophylactic antibiotics .',
  'Since a high-rate of recurrence is a serious problem for early stage urothelial carcinomas , new strategies for the management of recurrent urothelial carcinomas have been explored .',
  'Muscle invasive bladder cancer is a serious clinical problem and is fatal for the majority of patients .',
  'The management of high-grade ( HG ) non-muscle-invasive bladder cancer ( NMIBC ) continues to be a serious clinical problem .',
  'Recurrence is a serious problem in patients with bladder cancer .',
  'Bladder cancer ( BC ) is a serious medical problem .',
  'Pelvic recurrence following cystectomy is a devastating problem for both physician and patient .'],
 'amr': ['Antimicrobial resistance (AMR) is among the gravest threats to human health and food security worldwide',
  'Globally , antimicrobial resistance ( AMR ) is a serious problem causing 700,000 deaths annually .',
  'MDR bacterial infections are currently a serious problem for clinicians worldwide .',
  'Antimicrobial resistance ( AMR ) is a serious problem worldwide .',
  'In recent years , the antimicrobial resistance ( AMR ) or multidrug resistance ( MDR ) has become a serious health concern and major challenging issue , worldwide .',
  'The rise of antimicrobial resistance ( AMR ) is a severe global health problem .',
  'Antimicrobial resistance ( AMR ) is a serious concern in pathogenic bacteria .',
  'Antimicrobial resistance ( AMR ) is a serious public health problem and a global concern .',
  'Antimicrobial resistance ( AMR ) represents a serious problem globally , but it is especially pronounced in the tropics , where pressure of infectious diseases is high .',
  'MDR bacteria are frequently detected in humans and animals from both more- and less-developed countries and pose a serious concern for human health .',
  'The development of antimicrobial-resistant ( AMR ) bacteria poses a serious worldwide health concern .',
  'We outline why AMR is a serious endemic problem manifested in hospital and community-acquired infections .',
  'Antimicrobial resistance ( AMR ) has become a serious global public health problem .',
  'Antimicrobial Resistance ( AMR ) is a serious problem for the humans since it threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria , parasites , viruses and fungi .',
  'AMR is a serious global problem , and assessing the risk markers for the presence of drug-resistant bacteria in pets , a very close source of resistance determinants to humans , is essential for the implementation of safe handling procedures for companion animals and for the prudent selection of antimicrobial compounds in veterinary practice .'],
 'antimicrobial': ['Antimicrobial resistance (AMR) is among the gravest threats to human health and food security worldwide',
  'Globally , antimicrobial resistance ( AMR ) is a serious problem causing 700,000 deaths annually .',
  'MDR bacterial infections are currently a serious problem for clinicians worldwide .',
  'The occurrence of antibiotic resistant Neisseria gonorrhoeae isolates is a serious public health problem in different corners of the globe .',
  'Antimicrobial resistance ( AMR ) is a serious problem worldwide .',
  'The widespread antimicrobial resistance of Neisseria gonorrhoeae is a serious problem for the treatment and control of gonorrhoea .',
  'In recent years , the antimicrobial resistance ( AMR ) or multidrug resistance ( MDR ) has become a serious health concern and major challenging issue , worldwide .',
  'Antimicrobial resistance of Neisseria gonorrhoeae is a serious health problem in China .',
  'Gonorrhea in women : a serious health problem .',
  'Gonorrhoea is one of the most common sexually transmitted infections ( STIs ) in the world , and is a serious public health problem because of its associated morbidity and complications .',
  'The rise of antimicrobial resistance ( AMR ) is a severe global health problem .',
  'Multidrug resistance is a serious problem that threatens the effective treatment of the widespread sexually transmitted disease gonorrhea , caused by the Gram-negative bacterium',
  'Antimicrobial resistance ( AMR ) is a serious concern in pathogenic bacteria .',
  'Antimicrobial resistance ( AMR ) is a serious public health problem and a global concern .',
  'Antimicrobial resistance ( AMR ) represents a serious problem globally , but it is especially pronounced in the tropics , where pressure of infectious diseases is high .',
  'MDR bacteria are frequently detected in humans and animals from both more- and less-developed countries and pose a serious concern for human health .',
  'Antimicrobial resistance ( AMR ) in Neisseria gonorrhoeae is a serious public health problem , compromising the management and control of gonorrhoea globally .',
  'The development of antimicrobial-resistant ( AMR ) bacteria poses a serious worldwide health concern .',
  'The antimicrobial resistance of Neisseria gonorrhoeae is a serious problem worldwide .',
  'Emergence of multidrug-resistant ( MDR ) and extensively drug-resistant ( XDR ) Neisseria gonorrhoeae is a serious concern and combination therapy has been recommended to delay the onset of treatment failures .',
  'We outline why AMR is a serious endemic problem manifested in hospital and community-acquired infections .',
  'Neisseria gonorrhoeae ( NG ) infection is a serious public health problem .',
  'Antimicrobial resistance ( AMR ) has become a serious global public health problem .',
  'Increasing rates of gonococcal ( GC ) infection and antimicrobial resistant ( AMR ) GC , are a serious public health concern for Canada and around the world .',
  'Antimicrobial Resistance ( AMR ) is a serious problem for the humans since it threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria , parasites , viruses and fungi .',
  'Gonococcal infections are now an uncommon problem in newborns in industrialized countries but remain a serious problem in developing countries due to ongoing high infection rates in pregnant women .',
  'The sexually transmitted disease , gonorrhea , is a serious health problem in developed as well as in developing countries , for which treatment continues to be a challenge .',
  'However , this has not become a serious problem to date , as large scale evaluation has shown that the quinolones remain highly efficacious for the treatment of gonorrhoea .',
  'AMR is a serious global problem , and assessing the risk markers for the presence of drug-resistant bacteria in pets , a very close source of resistance determinants to humans , is essential for the implementation of safe handling procedures for companion animals and for the prudent selection of antimicrobial compounds in veterinary practice .'],
 'dating': ['Dating violence (DV) is still a global problem of enormous proportions',
  'Teen dating violence is a serious public health concern with numerous and long-lasting consequences .',
  'Prior research has established that violence in dating relationships is a serious social problem among adolescents and young adults .',
  'Financial disagreements have been identified as a severe source of discord in adult relationships , yet limited work has considered whether financial considerations contribute to conflict among younger samples .',
  'Because stalking has only recently been recognized as a serious social problem and criminal justice concern , it is not surprising that there is little consensus among lawmakers about what constitutes stalking .',
  'Such an investigation is important because previous research indicates that dating violence is a serious problem facing adolescents , teen magazines overemphasize the importance of romantic relationships , and teens who read this genre frequently or for education/advice are especially susceptible to its messages .',
  'Dating violence ( DV ) is a serious problem with devastating consequences .',
  'Violence in dating relationships constitutes a serious problem , thus , the study of related factors could help to better understand this violence and intervene in it .',
  'Dating violence is a serious and prevalent public health problem that is associated with numerous negative physical and psychological health outcomes , and yet there has been limited evaluation of prevention programs on college campuses .',
  'Dating violence is a serious and prevalent problem among college-aged dating couples .',
  'Dating violence is a serious public health problem .',
  'Violence between dating couples is a serious and prevalent problem among college students ( Shorey , Cornelius , & Bell , 2008 ) .',
  'Dating violence is a serious problem among adolescents and young adults .',
  'Teen dating violence is a serious public health problem with few effective prevention strategies .',
  'Teen dating violence ( TDV ) is a serious and prevalent public health problem .',
  'Much of what is presently known about stalking in a domestic context has been depicted by the popular press , typically following a tragic outcome , and suggests that it is a problem of increasing dimensions .',
  'Teen dating violence ( TDV ) is a serious public health concern that is associated with many negative effects .',
  'Teen dating violence is a serious health concern in the United States .',
  'Dating violence is a serious problem among college students .',
  'Interpersonal violence ( IPV ) in adolescence is a serious public health concern and may have lasting behavioral effects and implications for adult relationships .',
  'Teen dating violence is a serious public health problem .',
  'Teen dating violence ( TDV ) is a preventable public health problem that has negative consequences for youth .',
  'Dating violence is a serious and prevalent problem on college campuses .',
  'Stalking is a serious public health and societal concern affecting the college population .',
  'Stalking is a serious public health and societal concern affecting many college women .',
  'Although stalking has been increasingly recognized as a serious social problem , surprisingly few studies have investigated perceptions of the specific behaviors that comprise stalking .',
  'Stalking is a serious problem in the college community .',
  'Physical dating violence ( PDV ) victimization among adolescents is a serious global problem .',
  'Dating violence ( DV ) is a serious social problem among adolescents and emerging adults , both boys and girls are victims and perpetrators .',
  "The aim of this research was to know the factors associated with teen dating violence and victimization because violence in teenagers ' relationships is increasing in recent years , constituting a serious social problem .",
  'Stalking is a widespread phenomenon and a serious problem for healthcare .',
  'The findings confirm that dating violence among adolescents is a serious health problem that needs to be addressed .',
  'Dating violence is a serious and prevalent problem , with females being victimized by partners at high rates with numerous negative health consequences .'],
 'stalking': ['Dating violence (DV) is still a global problem of enormous proportions',
  'Teen dating violence is a serious public health concern with numerous and long-lasting consequences .',
  'Prior research has established that violence in dating relationships is a serious social problem among adolescents and young adults .',
  'Financial disagreements have been identified as a severe source of discord in adult relationships , yet limited work has considered whether financial considerations contribute to conflict among younger samples .',
  'Because stalking has only recently been recognized as a serious social problem and criminal justice concern , it is not surprising that there is little consensus among lawmakers about what constitutes stalking .',
  'Such an investigation is important because previous research indicates that dating violence is a serious problem facing adolescents , teen magazines overemphasize the importance of romantic relationships , and teens who read this genre frequently or for education/advice are especially susceptible to its messages .',
  'Dating violence ( DV ) is a serious problem with devastating consequences .',
  'Violence in dating relationships constitutes a serious problem , thus , the study of related factors could help to better understand this violence and intervene in it .',
  'Dating violence is a serious and prevalent public health problem that is associated with numerous negative physical and psychological health outcomes , and yet there has been limited evaluation of prevention programs on college campuses .',
  'Dating violence is a serious and prevalent problem among college-aged dating couples .',
  'Dating violence is a serious public health problem .',
  'Violence between dating couples is a serious and prevalent problem among college students ( Shorey , Cornelius , & Bell , 2008 ) .',
  'Dating violence is a serious problem among adolescents and young adults .',
  'Teen dating violence is a serious public health problem with few effective prevention strategies .',
  'Teen dating violence ( TDV ) is a serious and prevalent public health problem .',
  'Much of what is presently known about stalking in a domestic context has been depicted by the popular press , typically following a tragic outcome , and suggests that it is a problem of increasing dimensions .',
  'Teen dating violence ( TDV ) is a serious public health concern that is associated with many negative effects .',
  'Teen dating violence is a serious health concern in the United States .',
  'Dating violence is a serious problem among college students .',
  'Interpersonal violence ( IPV ) in adolescence is a serious public health concern and may have lasting behavioral effects and implications for adult relationships .',
  'Teen dating violence is a serious public health problem .',
  'Teen dating violence ( TDV ) is a preventable public health problem that has negative consequences for youth .',
  'Dating violence is a serious and prevalent problem on college campuses .',
  'Stalking is a serious public health and societal concern affecting the college population .',
  'Stalking is a serious public health and societal concern affecting many college women .',
  'Although stalking has been increasingly recognized as a serious social problem , surprisingly few studies have investigated perceptions of the specific behaviors that comprise stalking .',
  'Stalking is a serious problem in the college community .',
  'Physical dating violence ( PDV ) victimization among adolescents is a serious global problem .',
  'Dating violence ( DV ) is a serious social problem among adolescents and emerging adults , both boys and girls are victims and perpetrators .',
  "The aim of this research was to know the factors associated with teen dating violence and victimization because violence in teenagers ' relationships is increasing in recent years , constituting a serious social problem .",
  'Stalking is a widespread phenomenon and a serious problem for healthcare .',
  'The findings confirm that dating violence among adolescents is a serious health problem that needs to be addressed .',
  'Dating violence is a serious and prevalent problem , with females being victimized by partners at high rates with numerous negative health consequences .'],
 'violence': ['Dating violence (DV) is still a global problem of enormous proportions',
  "Violence against women , especially by intimate partners , is a serious public health problem that is associated with physical , reproductive and mental health consequences . Even though most societies proscribe violence against women , the reality is that violations against women 's rights are often sanctioned under the garb of cultural practices and norms , or through misinterpretation of religious tenets .",
  'Intimate partner violence ( IPV ) is a serious social problem that is often hidden , unnoticed or ignored .',
  'Intimate partner violence ( IPV ) is a serious public health problem in the United States with adverse consequences for affected individuals and families .',
  'Intimate partner violence ( IPV ) is a serious public health problem .',
  'The Centers for Disease Control and Prevention describes intimate partner violence ( IPV ) as a serious , preventable problem .',
  'Intimate partner violence ( IPV ) is a serious , and preventable , public health problem in the United States .',
  'Intimate partner violence ( IPV ) is a serious public health concern for all ; however , women who experience IPV are more likely to sustain injury and report adverse health consequences .',
  'Intimate partner violence ( IPV ) against women is a serious public health and social problem and is associated with a host of adverse health outcomes and behaviors , HIV risk behaviors included , among women who are victimized .',
  'Intimate partner violence ( IPV ) is a serious public health concern and impacts the entire family unit , particularly children .',
  'Intimate partner violence ( IPV ) is a serious public health problem that disproportionately affects adolescent women seeking family planning services .',
  'Intimate partner violence ( IPV ) is a serious , under-reported public health problem in the United States .',
  'Teen dating violence is a serious public health concern with numerous and long-lasting consequences .',
  'Prior research has established that violence in dating relationships is a serious social problem among adolescents and young adults .',
  "Intimate Partner Violence ( IPV ) is a serious violation of women 's human rights and a dominant chronic global public health problem .",
  'Financial disagreements have been identified as a severe source of discord in adult relationships , yet limited work has considered whether financial considerations contribute to conflict among younger samples .',
  'Although domestic violence ( DV ) is recognized as a serious crime , only recently has it been acknowledged as a critical public health problem .',
  'Intimate partner violence ( IPV ) against women is a serious problem throughout the world .',
  'Domestic violence is a serious problem affecting the health and wellbeing of women globally .',
  'Because stalking has only recently been recognized as a serious social problem and criminal justice concern , it is not surprising that there is little consensus among lawmakers about what constitutes stalking .',
  'Violence against women represents a serious concern worldwide .',
  'Intimate partner violence ( IPV ) is a serious public health problem that frequently results in oral-maxillofacial traumas , generating high social and economic costs .',
  'Intimate partner violence ( IPV ) , commonly accompanied by controlling behavior , is a serious public health concern in sub-Saharan Africa .',
  'Domestic abuse represents a serious public health and human rights concern .',
  'Intimate partner violence has long been recognized as a serious public health problem .',
  'These variables are what make violence against women a preventable problem .',
  'Domestic abuse is a serious problem that may present directly or indirectly in the clinical setting .',
  'Such an investigation is important because previous research indicates that dating violence is a serious problem facing adolescents , teen magazines overemphasize the importance of romantic relationships , and teens who read this genre frequently or for education/advice are especially susceptible to its messages .',
  "Intimate partner violence is a serious and pervasive social problem with deleterious consequences for survivors ' well-being .",
  'Dating violence ( DV ) is a serious problem with devastating consequences .',
  'Violence in dating relationships constitutes a serious problem , thus , the study of related factors could help to better understand this violence and intervene in it .',
  'Dating violence is a serious and prevalent public health problem that is associated with numerous negative physical and psychological health outcomes , and yet there has been limited evaluation of prevention programs on college campuses .',
  'There is growing recognition in the ranks of the South African government that violence against women is a serious problem facing us all .',
  'Intimate partner violence ( IPV ) is a serious public health concern that affects many Latinx couples .',
  'Intimate Partner Violence ( IPV ) is a serious international problem .',
  "Intimate partner violence ( IPV ) is a serious , widespread problem that negatively affects women 's lives , including their economic status .",
  'Domestic violence ( DV ) is a serious public health problem in the world .',
  'Research conducted in Australia and overseas provides an evidence base for the contention that violence against women is a serious problem for healthcare and society , and should be addressed comprehensively in both the healthcare and socio-legal context to protect the woman and the family .',
  "Intimate partner violence is a serious global public health problem particularly in low-and middle-income countries such as Ethiopia where women 's empowerment is limited .",
  'Gender-based violence against women migrant domestic workers ( WMDW ) is a serious public health concern in the Middle East region .',
  'Dating violence is a serious and prevalent problem among college-aged dating couples .',
  'Violence against women is a serious social problem and affects mainly young women .',
  'Dating violence is a serious public health problem .',
  'Although this was an exploratory study , the results attest that female abuse is a serious social problem in this community , and that the rate of abuse exceeds that of other Palestinian groups .',
  'Intimate partner violence ( IPV ) is a serious public health problem , affecting every 1 in 4 women in their lifetime .',
  'Intimate partner violence ( IPV ) is a serious mental and physical health concern worldwide .',
  'The study concludes that wife beating is a serious health and social problem for the women population of Kantale .',
  'Domestic violence is a serious public health problem .',
  'Domestic violence is a serious problem with far-reaching consequences .',
  'In the United States ( U.S. ) , intimate partner violence ( IPV ) is a serious public health concern , mainly affecting the health and well-being of women .',
  'Partner violence is a serious public health problem , due to their potential short- , medium- or long-term physical and psychological consequences .',
  'Domestic family violence ( FV ) is a serious problem with serious impacts on mental health of victims .',
  'Intimate partner violence is a preventable public health problem .',
  'Violence between dating couples is a serious and prevalent problem among college students ( Shorey , Cornelius , & Bell , 2008 ) .',
  'Spousal violence against women is a serious public health problem that is prevalent in all societies , with one in three women around the world experiencing violence in their lifetime .',
  'Dating violence is a serious problem among adolescents and young adults .',
  'Intimate partner violence ( IPV ) has emerged as a serious problem among women in drug treatment programs .',
  'Teen dating violence is a serious public health problem with few effective prevention strategies .',
  'Teen dating violence ( TDV ) is a serious and prevalent public health problem .',
  'Much of what is presently known about stalking in a domestic context has been depicted by the popular press , typically following a tragic outcome , and suggests that it is a problem of increasing dimensions .',
  'Sexual violence against women is a form of gender violence and both a severe human rights violation and public health problem .',
  'The Canadian government has introduced numerous policies , guidelines , and mandates at the federal and provincial levels that recognize woman abuse as a serious social problem and violation of the law .',
  'Domestic violence ( DV ) against women is a serious problem with its negative effects on all family members and the society .',
  'Intimate partner violence ( IPV ) is a serious public health problem leading many health care organizations to recommend universal screening as part of standard health care practice .',
  'Teen dating violence ( TDV ) is a serious public health concern that is associated with many negative effects .',
  'Domestic abuse is increasingly recognised as a serious , worldwide public health concern .',
  'Intimate partner violence ( IPV ) is a serious health concern , but little is known about prevalence of IPV in the armed forces , as military members cope with the pressures of long-standing operations .',
  'Domestic abuse of women is a serious problem worldwide that has economic , physical , and psychological consequences , yet in many countries and cultures , victims often have little access to psychological support .',
  'Violence against women is now widely recognized as a serious human right abuse , and an important public health problem with substantial consequences physical , mental , sexual , and reproductive health .',
  'Intimate partner physical violence was found to be high and a serious problem among women in Shimelba refugee camp .',
  'Teen dating violence is a serious health concern in the United States .',
  'Intimate partner violence against women ( IPVAW ) is a serious and widespread problem worldwide .',
  'Intimate partner violence is a preventable health problem that affects more than 12 million people in the United States each year .',
  'Dating violence is a serious problem among college students .',
  'Domestic violence ( DV ) is not only a devastating societal problem , but also a severe medical and mental health problem worldwide .',
  'In Sri Lanka , over one in three women experience intimate partner violence ( IPV ) victimization in their lifetime , making it a serious public health concern .',
  'Domestic intimate partner violence ( IPV ) is a serious health care concern , which may be mitigated by early detection , screening , and intervention .',
  'Given domestic violence continues to be a serious social problem , recently acknowledged as a national public health epidemic as well , the need to examine existing formal helping services and address the barriers to service utilization among battered women is warranted .',
  'Violence against women is widely recognized as a serious public health problem in the world .',
  'Spain seems to have a serious problem with public health and respecting human rights in obstetric violence .',
  'Intimate partner violence ( IPV ) is a serious and widespread problem .',
  'Intimate partner violence ( IPV ) is a serious public health problem with known negative physical and mental health outcomes for women exposed .',
  'Intimate Partner Violence ( IPV ) is a serious , preventable public health problem that affects millions of people worldwide .',
  'Gender violence is a human rights violation and a serious public health problem that should be addressed with an inter-sector and interdisciplinary focus .',
  'Intimate partner violence ( IPV ) directed towards women is a serious public health problem .',
  'Gender-based violence against women is a serious concern in India .',
  'The data about domestic violence against women point out a serious problem all around the world along with including cultural differences .',
  'Intimate partner violence ( IPV ) is a serious public health problem , linked with a number of poor health outcomes .',
  'It was observed that health professionals characterize violence against women as a severe and important problem in society , caused by and leading to gender inequality .',
  'These results underscore that domestic violence is a serious problem that must be addressed in Thai society .',
  'Interpersonal violence is a serious public health problem in the United States .',
  'Interpersonal violence ( IPV ) in adolescence is a serious public health concern and may have lasting behavioral effects and implications for adult relationships .',
  'Intimate partner violence ( IPV ) is a serious and preventable public health problem .',
  'Violence against women , especially by intimate partners , is a serious public health problem that is associated with physical , reproductive , and mental health consequences .',
  'Teen dating violence is a serious public health problem .',
  "Violence against women represents a serious violation of women 's human rights and has been recognized as a clinical and public health problem , independently of nationality , ethnicity , cultural norms and socioeconomic status .",
  'Family violence is a serious concern in the era of deinstitutionalization in Japan .',
  'Although domestic violence is seen as a serious public health issue for women worldwide , international evidence suggests that women aged over 50 who are victims are suffering in silence because the problem is often ignored by health professionals .',
  'Domestic violence is a serious public health concern in the United States .',
  'Teen dating violence ( TDV ) is a preventable public health problem that has negative consequences for youth .',
  'Intimate partner violence is a serious and pervasive problem in U.S. society , with 25 % of women and 7.6 % of men reporting physical abuse by an intimate partner each year .',
  "Intimate partner violence ( IPV ) violates women 's human rights and is a serious public health concern .",
  'Violence against women is a serious problem in Turkey .',
  'Intimate partner violence ( IPV ) is a serious , devastating , and prevalent problem .',
  'Intimate partner violence ( IPV ) is prevalent throughout the world and is a devastating public health problem .',
  'Intimate partner violence ( IPV ) is a serious , pervasive problem ; however , professional literature focused on psychotherapy for women experiencing IPV is limited .',
  'Domestic abuse is a serious problem across the world and it is considered a public health issue .',
  'Domestic abuse is a serious global problem and has greater , negative effects on long-term health than more obvious diseases , such as diabetes .',
  'The magnitude , physical and mental health consequences of domestic violence represents a serious reproductive health concern for Pakistan .',
  'Intimate partner violence ( IPV ) among immigrant women is a serious public health problem .',
  'Domestic violence , especially violence against women , is a serious health problem in the United States and in many countries of the world .',
  'Domestic violence , a serious health problem , affects millions of people every year .',
  'Intimate partner violence is a serious international problem .',
  'Dating violence is a serious and prevalent problem on college campuses .',
  'Intimate partner violence constitutes a serious health problem worldwide .',
  'Intimate partner violence ( IPV ) is a serious public health problem in the United States and a common cause of injury .',
  'Intimate partner violence ( IPV ) is a severe health problem associated with significant distress and impairment in women .',
  'Stalking is a serious public health and societal concern affecting the college population .',
  'Stalking is a serious public health and societal concern affecting many college women .',
  'Violence against women is a serious health and social problem for women worldwide .',
  'Domestic violence against women is regarded as an important health problem among women and a serious concern in issues related to human rights .',
  'Although stalking has been increasingly recognized as a serious social problem , surprisingly few studies have investigated perceptions of the specific behaviors that comprise stalking .',
  'Domestic violence and partner violence against women is a serious problem in many countries , including Germany .',
  'Intimate partner homicide ( IPH ) is a serious problem throughout the world .',
  'Given the small number of adult women in Yap , these findings suggest that domestic violence is a serious , pervasive problem that Yap needs urgently to address .',
  'violence against women is a serious problem caused by the social construction of feminineness and masculineness that results in the domination of women by men .',
  'Intimate partner violence ( IPV ) is a serious public health problem associated with increased risk of developing mental health conditions .',
  'Violence against women is recognized by globally as a serious health and social problem that impedes development .',
  'Domestic violence is a serious , complex , public health problem , which is more common than many physicians realize .',
  'Intimate partner violence ( IPV ) is a serious global health problem affecting millions of women worldwide .',
  'Intimate partner violence ( IPV ) is a serious problem with devastating health consequences .',
  'Stalking is a serious problem in the college community .',
  'Domestic abuse is increasingly recognised as a serious public health concern worldwide .',
  'Intimate partner violence is a serious social problem and public health issue affecting the well-being of the young adults .',
  'Domestic violence is a serious problem in the United States , with almost two million incidents occurring every year .',
  'Intimate partner violence ( IPV ) is a serious concern for women that is associated with significant adverse health effects .',
  'Violence against women ( VAW ) is a serious public health and human rights concern .',
  'Domestic violence is a serious , preventable health problem affecting more than thirty million Americans annually , yet little is known about federally funded service provision .',
  'Physical dating violence ( PDV ) victimization among adolescents is a serious global problem .',
  'Intimate partner violence ( IPV ) victimization is a serious public health problem in the world .',
  'IPV is thought to be a serious problem in Guyana , and this study confirms a high prevalence ( 16 % ) of IPV in women presenting with traumatic injuries to the Georgetown Public Hospital Corporation ED . This is likely a significant underestimate of the true prevalence .',
  'Intimate partner violence ( IPV ) is a serious social problem in South Korea , but the IPV reporting rate to the police is not high enough .',
  'Intimate partner violence against women ( IPV ) has been identified as a serious public health problem .',
  'Only recently has Japanese society come to realize the magnitude of domestic violence as a serious social problem .',
  'Dating violence ( DV ) is a serious social problem among adolescents and emerging adults , both boys and girls are victims and perpetrators .',
  'Domestic violence is a serious and often underreported problem .',
  "The aim of this research was to know the factors associated with teen dating violence and victimization because violence in teenagers ' relationships is increasing in recent years , constituting a serious social problem .",
  'Stalking is a widespread phenomenon and a serious problem for healthcare .',
  'Intimate partner violence ( IPV ) is a serious and prevalent problem throughout the United States .',
  'Intimate partner violence ( IPV ) is a serious health problem and a leading cause of nonfatal injury in North American females .',
  'The findings confirm that dating violence among adolescents is a serious health problem that needs to be addressed .',
  'Intimate partner violence ( IPV ) is a serious public health problem that disproportionately affects racial/ethnic minorities in the U.S. This study examines risk factors for IPV perpetration that are salient for racial/ethnic minorities ; specifically , we test if racial/ethnic discrimination among Latino men is associated with IPV perpetration , if poor mental health ( MH ) mediates this link , and whether relationships differ by immigrant status .',
  'Gender-based violence ( GBV ) is a serious global public health problem that becomes aggravated during public health emergencies that involve quarantine measures .',
  'Female same-sex intimate partner violence ( FSSIPV ) is a serious problem that affects the health and safety of lesbian and bisexual women .',
  'Domestic violence is a serious and highly prevalent concern among this group of South Asian women .',
  'Dating violence is a serious and prevalent problem , with females being victimized by partners at high rates with numerous negative health consequences .',
  "Domestic violence is a serious public health concern often ' hidden ' by the lack of appropriate data .",
  'Domestic violence is a dangerous and prevalent social problem affecting up to 4 million women and countless children annually .',
  'Intimate partner violence is a serious public health concern in the United States .',
  'Intimate partner violence is a serious public health problem accompanied by substantial morbidity and mortality .',
  'Domestic violence ( DV ) against women is a serious human rights abuse and well recognised global public health concern .',
  'Intimate partner violence ( IPV ) is a serious health concern for women in the United States , and HIV-positive women experience more frequent and severe abuse compared with HIV-negative women .',
  'Violence against women by their male partners is a serious public health problem that has not been adequately addressed by the medical and psychiatric professions .',
  'One-in-three women has experienced domestic violence , which is a serious public health problem and a human right violation .',
  'Intimate partner violence ( IPV ) is a serious public health problem that has received increased attention in the military .',
  'Domestic violence ( DV ) is a serious problem all over the world which had been extended to boundaries of countries , economical , cultural and racial classes .',
  'Domestic violence is a serious public health and human rights concern and an on-going challenge for nursing .',
  "Domestic violence is a serious women 's health and societal problem .",
  'Violence against women represents a serious problem in America .',
  'Multiple regression analysis identified the following statistically significant confounders : victimization , the presence of a person with a severe health problem at home , female sex , engaging in limited physical exercise , and living in a single adult family .'],
 'relationships': ['Dating violence (DV) is still a global problem of enormous proportions',
  'Teen dating violence is a serious public health concern with numerous and long-lasting consequences .',
  'Prior research has established that violence in dating relationships is a serious social problem among adolescents and young adults .',
  'Financial disagreements have been identified as a severe source of discord in adult relationships , yet limited work has considered whether financial considerations contribute to conflict among younger samples .',
  'Because stalking has only recently been recognized as a serious social problem and criminal justice concern , it is not surprising that there is little consensus among lawmakers about what constitutes stalking .',
  'Such an investigation is important because previous research indicates that dating violence is a serious problem facing adolescents , teen magazines overemphasize the importance of romantic relationships , and teens who read this genre frequently or for education/advice are especially susceptible to its messages .',
  'Dating violence ( DV ) is a serious problem with devastating consequences .',
  'Violence in dating relationships constitutes a serious problem , thus , the study of related factors could help to better understand this violence and intervene in it .',
  'Dating violence is a serious and prevalent public health problem that is associated with numerous negative physical and psychological health outcomes , and yet there has been limited evaluation of prevention programs on college campuses .',
  'Dating violence is a serious and prevalent problem among college-aged dating couples .',
  'Dating violence is a serious public health problem .',
  'Violence between dating couples is a serious and prevalent problem among college students ( Shorey , Cornelius , & Bell , 2008 ) .',
  'Dating violence is a serious problem among adolescents and young adults .',
  'Teen dating violence is a serious public health problem with few effective prevention strategies .',
  'Teen dating violence ( TDV ) is a serious and prevalent public health problem .',
  'Much of what is presently known about stalking in a domestic context has been depicted by the popular press , typically following a tragic outcome , and suggests that it is a problem of increasing dimensions .',
  'Teen dating violence ( TDV ) is a serious public health concern that is associated with many negative effects .',
  'Teen dating violence is a serious health concern in the United States .',
  'Dating violence is a serious problem among college students .',
  'Interpersonal violence ( IPV ) in adolescence is a serious public health concern and may have lasting behavioral effects and implications for adult relationships .',
  'Teen dating violence is a serious public health problem .',
  'Teen dating violence ( TDV ) is a preventable public health problem that has negative consequences for youth .',
  'Dating violence is a serious and prevalent problem on college campuses .',
  'Stalking is a serious public health and societal concern affecting the college population .',
  'Stalking is a serious public health and societal concern affecting many college women .',
  'Although stalking has been increasingly recognized as a serious social problem , surprisingly few studies have investigated perceptions of the specific behaviors that comprise stalking .',
  'Stalking is a serious problem in the college community .',
  'Physical dating violence ( PDV ) victimization among adolescents is a serious global problem .',
  'Dating violence ( DV ) is a serious social problem among adolescents and emerging adults , both boys and girls are victims and perpetrators .',
  "The aim of this research was to know the factors associated with teen dating violence and victimization because violence in teenagers ' relationships is increasing in recent years , constituting a serious social problem .",
  'Stalking is a widespread phenomenon and a serious problem for healthcare .',
  'The findings confirm that dating violence among adolescents is a serious health problem that needs to be addressed .',
  'Dating violence is a serious and prevalent problem , with females being victimized by partners at high rates with numerous negative health consequences .'],
 'bullying': ['Bullying in the workplace is a serious public health issue',
  "One problem with this reporting is that the victim 's reports of bullying may become overshadowed by the bully 's reports of victim incompetence , resulting in the victim experiencing further victimization .",
  'Bullying is a serious problem in this group of workers and may lead to health consequences .',
  'Although bullying is recognized as a serious problem among adolescents , more information is needed regarding bullying within the context of physical education .',
  'Bullying is a serious problem in workplaces with consequences for the individual , the organisation and the quality of care .',
  'School bullying is a serious problem among teenagers .',
  'Bullying victimization in school settings is a serious problem in many countries including the United States .',
  'Workplace bullying is a serious problem faced by nurses nationally .',
  'Despite existing efforts to prevent bullying , research suggests that bullying remains a serious and common problem across the United States .',
  'Although bullying has been identified as a serious problem in the health care sector , little attention has been given to the possible effect of workplace bullying on long-term sickness absence and its implications .',
  'Bullying in nursing workplaces has been considered a serious problem that increases nurse turnover .',
  'Bullying is a serious public health concern across the globe .',
  'Exposure to workplace bullying has been argued to be a severe social stressor and a more crippling and devastating problem for affected individuals than the effects of all other work-related stressors put together .',
  "Bullying is a severe public health problem , and bystanders ' reactions are a key variable in its perpetration and maintenance .",
  'Workplace bullying is a serious problem affecting nursing .',
  'Psychologists recognize homophobic bullying as a serious problem for young lesbians and gay men ; however , when it comes to children in lesbian and gay households the issue is not so clear cut .',
  'School bullying is a serious social problem that results in potentially severe and long lasting consequences for youth , parents , teachers , and school officials .',
  'Bullying victimization in school students is a serious public health concern and has been linked to a wide range of mental health problems .',
  'School bullying is a serious , worldwide problem which is not easily counteracted .',
  'Workplace bullying is increasingly being recognized as a serious problem within the work environment .',
  'School bullying continues to be a serious problem around the world .',
  'First , does the public perceive bullying as a serious problem and judge schools-primary , secondary , and postsecondary-as safe or unsafe ?',
  'Irrespective of bullying status , delinquency is a serious problem for urban adolescents who are bullies , victims , or bully/victims .',
  'Violence and bullying in the school setting are a serious social and health problem that have created great alarm in the last few years .',
  'Bullying is a serious and growing problem affecting a significant proportion of healthcare professionals , a professional category exposed to work-related stress .',
  'Bullying is a serious public health problem , and many studies have examined the effect of school-based anti-bullying programs .',
  'Bullying has been shown to be a serious problem amongst school children , but few studies have been population-based and included pre-school children .',
  'Workplace bullying seems to be a serious problem in the French working life given the prevalence observed here ( around 10 % ) .',
  'Bullying is a serious problem in schools in Turkey and is a matter of recent concern .',
  'School bullying is a serious problem affecting the victims in their daily lives at school .',
  'Bullying is a serious public health problem that may include verbal or physical injury as well as social isolation or exclusion .',
  'Workplace bullying among nurse educators is a serious problem impacting the profession .',
  'Bullying among youth is recognized as a serious student problem , especially in middle school .',
  'Workplace bullying is a serious problem that hinders the provision of quality care services by seriously affecting their physical , psychological , and social health status .',
  'Bullying victimization among Chinese school-aged children has recently been recognized as a serious problem .',
  'Bullying and victimization behaviors are a serious problem for students , peers , parents , and school teachers .',
  'Bullying is a serious public health concern remarkably common among youth .',
  'Bullying remains a troubling problem in the nursing profession .',
  'Bullying is a serious public health concern that is associated with significant negative mental , social , and physical outcomes .',
  'Bullying is a serious problem .',
  'Bullying is a serious problem for schools , parents , and public-policymakers alike .'],
 'workplaces': ['Bullying in the workplace is a serious public health issue',
  'Bullying is a serious problem in this group of workers and may lead to health consequences .',
  'Bullying is a serious problem in workplaces with consequences for the individual , the organisation and the quality of care .',
  'Workplace bullying is a serious problem faced by nurses nationally .',
  'Although bullying has been identified as a serious problem in the health care sector , little attention has been given to the possible effect of workplace bullying on long-term sickness absence and its implications .',
  'Bullying in nursing workplaces has been considered a serious problem that increases nurse turnover .',
  'Exposure to workplace bullying has been argued to be a severe social stressor and a more crippling and devastating problem for affected individuals than the effects of all other work-related stressors put together .',
  'Workplace bullying is a serious problem affecting nursing .',
  'Workplace bullying is increasingly being recognized as a serious problem within the work environment .',
  'Bullying is a serious and growing problem affecting a significant proportion of healthcare professionals , a professional category exposed to work-related stress .',
  'Workplace bullying seems to be a serious problem in the French working life given the prevalence observed here ( around 10 % ) .',
  'Workplace bullying among nurse educators is a serious problem impacting the profession .',
  'Workplace bullying is a serious problem that hinders the provision of quality care services by seriously affecting their physical , psychological , and social health status .',
  'Bullying remains a troubling problem in the nursing profession .'],
 'arthritis': ["The Problem with Gout Is That It 's Still Such a Problem .",
  'The arthritis patient poses a vexing problem in a variety of ways .',
  'Rheumatoid arthritis ( RA ) poses a serious health problem as a chronic autoimmune joint disease with significant mortality and morbidity .',
  'Rheumatoid arthritis is considered a serious public health problem , which is commonly treated with traditional Chinese or herbal medicine .',
  'The average annual cost of gonarthrosis is relatively low , but when related to prevalence and prevalence trends , it can become a serious problem for health services .',
  "Acute rheumatic fever remains a serious healthcare concern for the majority of the world 's population despite its decline in incidence in Europe and North America .",
  'Rheumatic diseases are a serious medical and social problem .',
  'Cardiovascular ( CV ) diseases are a serious concern in rheumatoid arthritis ( RA ) , accounting for approximately one-third to one-half of all RA-related deaths .',
  'The rheumatological complications in HIV positive patients are rather common and are recognized as a serious problem that requires more attention .',
  'Rheumatoid arthritis ( RA ) is a serious medical problem , with approximately 1 % of the people in the world affected .',
  'A disturbance in gait pattern is a serious problem in patients with rheumatoid arthritis ( RA ) .',
  "Rheumatic Diseases ( RDs ) are a serious , though often not sufficiently recognized , problem ; strongly impacting not only patients ' socio-economic activity but their quality of life in general .",
  'Gout is a serious medical problem in our centre .',
  'A failure to respond to TNF inhibitors remains a serious concern for patients with RA .',
  'Rheumatoid arthritis ( RA ) is a serious health problem resulting in significant morbidity and disability .',
  'It is concluded that in spite of the declining incidence and milder course of acute rheumatic fever , the disease still remains a serious public health problem due to a possible cardiac damage .',
  'Rheumatic fever continues to be a serious health problem .',
  'The combination of gastroduodenal pathology of diseases of the joints is a serious problem for modern medicine , due to the high incidence of arthritis in the population , not only the defeat ofjoints , bijt also of many other organs and systems .',
  'Rheumatic heart disease ( RHD ) is a serious health concern in developing countries .',
  'Although tumor necrosis factor (TNF)-α inhibitors are effective in patients with rheumatoid arthritis ( RA ) , an increased risk of infections often becomes a serious problem .',
  'Rheumatic Fever represents a serious public health problem in developing countries , with thousands of new cases each year .'],
 'rheumatic': ["The Problem with Gout Is That It 's Still Such a Problem .",
  'The arthritis patient poses a vexing problem in a variety of ways .',
  'Rheumatoid arthritis ( RA ) poses a serious health problem as a chronic autoimmune joint disease with significant mortality and morbidity .',
  'Rheumatoid arthritis is considered a serious public health problem , which is commonly treated with traditional Chinese or herbal medicine .',
  'The average annual cost of gonarthrosis is relatively low , but when related to prevalence and prevalence trends , it can become a serious problem for health services .',
  "Acute rheumatic fever remains a serious healthcare concern for the majority of the world 's population despite its decline in incidence in Europe and North America .",
  'Rheumatic diseases are a serious medical and social problem .',
  'Cardiovascular ( CV ) diseases are a serious concern in rheumatoid arthritis ( RA ) , accounting for approximately one-third to one-half of all RA-related deaths .',
  'The rheumatological complications in HIV positive patients are rather common and are recognized as a serious problem that requires more attention .',
  'Rheumatoid arthritis ( RA ) is a serious medical problem , with approximately 1 % of the people in the world affected .',
  'A disturbance in gait pattern is a serious problem in patients with rheumatoid arthritis ( RA ) .',
  "Rheumatic Diseases ( RDs ) are a serious , though often not sufficiently recognized , problem ; strongly impacting not only patients ' socio-economic activity but their quality of life in general .",
  'Gout is a serious medical problem in our centre .',
  'A failure to respond to TNF inhibitors remains a serious concern for patients with RA .',
  'Rheumatoid arthritis ( RA ) is a serious health problem resulting in significant morbidity and disability .',
  'It is concluded that in spite of the declining incidence and milder course of acute rheumatic fever , the disease still remains a serious public health problem due to a possible cardiac damage .',
  'Rheumatic fever continues to be a serious health problem .',
  'The combination of gastroduodenal pathology of diseases of the joints is a serious problem for modern medicine , due to the high incidence of arthritis in the population , not only the defeat ofjoints , bijt also of many other organs and systems .',
  'Rheumatic heart disease ( RHD ) is a serious health concern in developing countries .',
  'Although tumor necrosis factor (TNF)-α inhibitors are effective in patients with rheumatoid arthritis ( RA ) , an increased risk of infections often becomes a serious problem .',
  'Rheumatic Fever represents a serious public health problem in developing countries , with thousands of new cases each year .'],
 'rheumatoid': ["The Problem with Gout Is That It 's Still Such a Problem .",
  'The arthritis patient poses a vexing problem in a variety of ways .',
  'Rheumatoid arthritis ( RA ) poses a serious health problem as a chronic autoimmune joint disease with significant mortality and morbidity .',
  'Rheumatoid arthritis is considered a serious public health problem , which is commonly treated with traditional Chinese or herbal medicine .',
  'The average annual cost of gonarthrosis is relatively low , but when related to prevalence and prevalence trends , it can become a serious problem for health services .',
  "Acute rheumatic fever remains a serious healthcare concern for the majority of the world 's population despite its decline in incidence in Europe and North America .",
  'Rheumatic diseases are a serious medical and social problem .',
  'Cardiovascular ( CV ) diseases are a serious concern in rheumatoid arthritis ( RA ) , accounting for approximately one-third to one-half of all RA-related deaths .',
  'The rheumatological complications in HIV positive patients are rather common and are recognized as a serious problem that requires more attention .',
  'Rheumatoid arthritis ( RA ) is a serious medical problem , with approximately 1 % of the people in the world affected .',
  'A disturbance in gait pattern is a serious problem in patients with rheumatoid arthritis ( RA ) .',
  "Rheumatic Diseases ( RDs ) are a serious , though often not sufficiently recognized , problem ; strongly impacting not only patients ' socio-economic activity but their quality of life in general .",
  'Gout is a serious medical problem in our centre .',
  'A failure to respond to TNF inhibitors remains a serious concern for patients with RA .',
  'Rheumatoid arthritis ( RA ) is a serious health problem resulting in significant morbidity and disability .',
  'It is concluded that in spite of the declining incidence and milder course of acute rheumatic fever , the disease still remains a serious public health problem due to a possible cardiac damage .',
  'Rheumatic fever continues to be a serious health problem .',
  'The combination of gastroduodenal pathology of diseases of the joints is a serious problem for modern medicine , due to the high incidence of arthritis in the population , not only the defeat ofjoints , bijt also of many other organs and systems .',
  'Rheumatic heart disease ( RHD ) is a serious health concern in developing countries .',
  'Although tumor necrosis factor (TNF)-α inhibitors are effective in patients with rheumatoid arthritis ( RA ) , an increased risk of infections often becomes a serious problem .',
  'Rheumatic Fever represents a serious public health problem in developing countries , with thousands of new cases each year .'],
 'wounds': ['The main problem with surgery is that clubfoot wounds heal by a patching up process called repair .',
  'A major problem associated with chronic wounds is that they are easily prone to infections .',
  'A problem with the acute TM perforation model is that most acute TM perforations will heal spontaneously , both in animals and human beings .',
  'However , a major drawback of TES products is a lack of skin appendages and nerves to enhance skin healing , structural integrity and skin vitality .',
  'Skin regeneration is a vexing problem in the field of regenerative medicine .',
  'Wound infection is a serious problem in the home care patient .',
  'Skin disease continues to be a vexing problem for amputees and those who care for them .',
  'Wound healing is still a serious medical problem due to process complexity and lack of effective medicaments .',
  'Osseous reconstruction is an important component in ulcer healing and prevention ; however , despite such efforts , major LEAs remain a serious postreconstruction concern .',
  'For hundreds of years poor and chronic nonhealing wounds have constituted a serious problem to medicine .',
  'Chronic wounds represent a serious problem in daily medical routine requiring improved wound care .',
  'Chronic wounds are still regarded as a serious public health concern , which are on the increase mainly due to the changes in life styles and aging of the human population .',
  'Skin tears are a serious , painful problem for older patients .',
  'Chronic wounds represent a serious problem for patients in terms of quality of life , lost employment time , and loss of income .',
  'Wound care is a serious healthcare concern , often complicated by prolonged inflammation and bacterial infection , which contributes significantly to mortality and morbidity .',
  'Wound pain is a serious problem for people with chronic wounds .',
  'Chronic dermal wounds are a devastating problem , which disproportionally affect individuals with conditions such as diabetes , paralysis , or simply old age .',
  'Since wound healing represents a severe problem in equine dermatology , our data may be essential for the establishment of new and improved therapy .',
  'Chronic wounds are a serious problem that could cause severe morbidity and even death .',
  'Corticosteriods have been shown to impair wound healing , which has become a serious clinical problem in wound care .',
  'Wound infection is a serious clinical problem , and the most common infection-causing bacteria are Staphylococcus aureus and Pseudomonas aeruginosa .',
  'Alterations in skin integrity represent a serious problem in the pediatric inpatient setting .',
  'Chronic wounds are a significant cause of morbidity and mortality for many patients and therefore constitute a serious clinical concern .',
  'Disorders of wound healing characterized by impaired or delayed re-epithelialization are a serious medical problem .',
  'Chronic wounds constitute a debilitating health care problem with significant clinical and social implications .',
  'Wounds continue to be a serious medical concern due to their increasing incidence from injuries , surgery , burns and chronic diseases such as diabetes .',
  'The biological process of wound healing is one of the most complex occurrences during our lives turning a serious public health problem .',
  'Abolished or delayed wound healing is a serious problem in clinical surgery , therefore , the new therapy for wound healing is needed .',
  'Recently , despite the current medical progress , the chronic and non-healing wounds still represent a serious medical problem .',
  'Delayed wound healing is a serious clinical problem in patients after surgery .',
  'Troubles can arise during the re-epithelialization phase of skin wound healing particularly in keratinocyte migration , resulting in chronic non-healing lesions , which represent a serious clinical problem .',
  'Skin wound healing is a serious clinical problem especially after surgery and severe injury of the skin .',
  'Wounds , burns , cuts , and scarring may cause a serious problem for human health if left untreated , and medicinal plants are identified as potentially useful for wound healing .',
  'A serious obstacle towards widespread use of stem cells for tissue regeneration is the challenges that face these cells when they are placed in vivo into a wound for therapy .',
  'Progressive antibiotic resistance is a serious condition adding to the challenges associated with skin wound treatment , and antibacterial wound dressings with alternatives to antibiotics are urgently needed .',
  'Chronic or non-healing wounds are a serious problem for both the parties involved and the healthcare system .',
  'Chronic nonhealed wound after below-knee amputation is a serious problem that is faced by the health care team ; therefore , there is a need to find an adjuvant therapy to address this problem .',
  'Chronic infected non-healing wounds represent a serious concern for health care systems .',
  'Chronic wounds constitute a serious public health problem , and developing pharmaceutical dosage forms to ensure patient comfort and safety , as well as optimizing treatment effectiveness , are of great interest in the pharmaceutical , medical and biomaterial fields .',
  'Woundhealing disorders characterized by impaired or delayed re-epithelialization are a serious medical problem that is painful and difficult to treat .',
  'Chronic wounds seem to be a severe problem in terms of its socioeconomical meaning due to the fact that the average age of patients suffering from these wounds is rising steadily .',
  'Chronic wounds seem to be a severe problem in terms of socioeconomical meanings due to the fact , that the average age of patients suffering from these wounds rises steadily .',
  'Treatment of non-healing wounds represents hitherto a severe dilemma because of their failure to heal caused by repeated tissue insults , bacteria contamination and altered physiological condition .',
  'Disorders of wound healing characterized by impaired or delayed re-epithelialization are a serious medical problem .',
  'Wound healing impairment is a serious problem in surgical disciplines which may be associated with chronic morbidity , increased cost and patient discomfort .',
  'Management of skin wound infections presents a serious problem in the clinic , in the community , and in both civilian and military clinical treatment centers .',
  'Wound healing disorders characterised by impaired or delayed reepithelialisation are a serious medical problem .',
  'Despite recent advances in bioengineered therapies , wound healing remains a serious clinical problem .',
  'Despite the development of advanced antibacterial materials , bacterial infection is still a serious problem for wound healing because it usually induces severe complications and can not be eradicated completely .',
  'Contracture of split skin grafts in burns injuries remains a serious problem and this in vitro model provides an opportunity to study keratinocyte/mesenchymal cell interactions and cell interactions with extracted normal human dermis .',
  'Non-healing wounds are a serious social and economic problem for patients .',
  'Chronic wounds are a serious healthcare problem .'],
 'wound': ['The main problem with surgery is that clubfoot wounds heal by a patching up process called repair .',
  'A major problem associated with chronic wounds is that they are easily prone to infections .',
  'A problem with the acute TM perforation model is that most acute TM perforations will heal spontaneously , both in animals and human beings .',
  'However , a major drawback of TES products is a lack of skin appendages and nerves to enhance skin healing , structural integrity and skin vitality .',
  'Skin regeneration is a vexing problem in the field of regenerative medicine .',
  'Wound infection is a serious problem in the home care patient .',
  'Skin disease continues to be a vexing problem for amputees and those who care for them .',
  'Impaired wound healing is a serious concern of uncontrolled hyperglycemia that can lead to gangrene , and even death .',
  'The risk of infection is higher and infections are a serious clinical problem in patients with type 1 ( insulin-dependent ) diabetes mellitus ( T1DM ) .',
  'Diabetes mellitus is a serious public health problem in which a major complication is impaired wound healing .',
  'Wound healing is still a serious medical problem due to process complexity and lack of effective medicaments .',
  'Osseous reconstruction is an important component in ulcer healing and prevention ; however , despite such efforts , major LEAs remain a serious postreconstruction concern .',
  'For hundreds of years poor and chronic nonhealing wounds have constituted a serious problem to medicine .',
  'Chronic wounds represent a serious problem in daily medical routine requiring improved wound care .',
  'Chronic wounds are still regarded as a serious public health concern , which are on the increase mainly due to the changes in life styles and aging of the human population .',
  'Skin tears are a serious , painful problem for older patients .',
  'Chronic wounds represent a serious problem for patients in terms of quality of life , lost employment time , and loss of income .',
  'The unknown mechanisms of impaired tissue repair in diabetes mellitus are making this disease a serious clinical problem for the physicians worldwide .',
  'Wound care is a serious healthcare concern , often complicated by prolonged inflammation and bacterial infection , which contributes significantly to mortality and morbidity .',
  'Wound pain is a serious problem for people with chronic wounds .',
  'Chronic dermal wounds are a devastating problem , which disproportionally affect individuals with conditions such as diabetes , paralysis , or simply old age .',
  'Delayed repair is a serious public health concern for diabetic populations .',
  'Since wound healing represents a severe problem in equine dermatology , our data may be essential for the establishment of new and improved therapy .',
  'Chronic wounds are a serious problem that could cause severe morbidity and even death .',
  'Corticosteriods have been shown to impair wound healing , which has become a serious clinical problem in wound care .',
  'Wound infection is a serious clinical problem , and the most common infection-causing bacteria are Staphylococcus aureus and Pseudomonas aeruginosa .',
  'Impaired diabetic wound healing represents a devastating and rapidly growing clinical problem associated with high morbidity , mortality , and recurrence rates .',
  'Alterations in skin integrity represent a serious problem in the pediatric inpatient setting .',
  'Chronic wounds are a significant cause of morbidity and mortality for many patients and therefore constitute a serious clinical concern .',
  'Disorders of wound healing characterized by impaired or delayed re-epithelialization are a serious medical problem .',
  'Chronic wounds constitute a debilitating health care problem with significant clinical and social implications .',
  'Diabetes-related chronic cutaneous lesions are a serious and common problem , as well as a major cause for hospital admissions , although no general consensus has been reached on the best available treatment for this frequent pathological condition .',
  'Impaired wound healing is a serious problem for diabetic patients .',
  'Wounds continue to be a serious medical concern due to their increasing incidence from injuries , surgery , burns and chronic diseases such as diabetes .',
  'The biological process of wound healing is one of the most complex occurrences during our lives turning a serious public health problem .',
  'Abolished or delayed wound healing is a serious problem in clinical surgery , therefore , the new therapy for wound healing is needed .',
  'Wound healing is a troublesome problem in diabetic patients .',
  'Recently , despite the current medical progress , the chronic and non-healing wounds still represent a serious medical problem .',
  'Delayed wound healing is a serious clinical problem in patients after surgery .',
  'Troubles can arise during the re-epithelialization phase of skin wound healing particularly in keratinocyte migration , resulting in chronic non-healing lesions , which represent a serious clinical problem .',
  'Skin wound healing is a serious clinical problem especially after surgery and severe injury of the skin .',
  'Impaired wound healing is a complication of diabetes and is a serious problem in clinical practice .',
  'Wounds , burns , cuts , and scarring may cause a serious problem for human health if left untreated , and medicinal plants are identified as potentially useful for wound healing .',
  'A serious obstacle towards widespread use of stem cells for tissue regeneration is the challenges that face these cells when they are placed in vivo into a wound for therapy .',
  'Impaired wound healing is a complication of diabetes and a serious problem in clinical practice .',
  'In diabetic patients , impairment of wound healing is a serious problem which represents a significant health burden .',
  'Progressive antibiotic resistance is a serious condition adding to the challenges associated with skin wound treatment , and antibacterial wound dressings with alternatives to antibiotics are urgently needed .',
  'Chronic or non-healing wounds are a serious problem for both the parties involved and the healthcare system .',
  'Chronic nonhealed wound after below-knee amputation is a serious problem that is faced by the health care team ; therefore , there is a need to find an adjuvant therapy to address this problem .',
  'Chronic infected non-healing wounds represent a serious concern for health care systems .',
  'Chronic wounds constitute a serious public health problem , and developing pharmaceutical dosage forms to ensure patient comfort and safety , as well as optimizing treatment effectiveness , are of great interest in the pharmaceutical , medical and biomaterial fields .',
  'Woundhealing disorders characterized by impaired or delayed re-epithelialization are a serious medical problem that is painful and difficult to treat .',
  'Chronic wounds seem to be a severe problem in terms of its socioeconomical meaning due to the fact that the average age of patients suffering from these wounds is rising steadily .',
  'Chronic wounds seem to be a severe problem in terms of socioeconomical meanings due to the fact , that the average age of patients suffering from these wounds rises steadily .',
  'Treatment of non-healing wounds represents hitherto a severe dilemma because of their failure to heal caused by repeated tissue insults , bacteria contamination and altered physiological condition .',
  'Disorders of wound healing characterized by impaired or delayed re-epithelialization are a serious medical problem .',
  'Wound healing impairment is a serious problem in surgical disciplines which may be associated with chronic morbidity , increased cost and patient discomfort .',
  'Prolonged healing is a severe problem for elderly and diabetic patients .',
  'SSFN may be a serious factor in observations of impaired wound healing among obese subjects , a particularly worrisome problem in an obese aging population given the propensity for small fiber impairment in aging subjects .',
  'Management of skin wound infections presents a serious problem in the clinic , in the community , and in both civilian and military clinical treatment centers .',
  'Wound healing disorders characterised by impaired or delayed reepithelialisation are a serious medical problem .',
  'Despite recent advances in bioengineered therapies , wound healing remains a serious clinical problem .',
  'Despite the development of advanced antibacterial materials , bacterial infection is still a serious problem for wound healing because it usually induces severe complications and can not be eradicated completely .',
  'Contracture of split skin grafts in burns injuries remains a serious problem and this in vitro model provides an opportunity to study keratinocyte/mesenchymal cell interactions and cell interactions with extracted normal human dermis .',
  'Non-healing wounds are a serious social and economic problem for patients .',
  'Chronic wounds are a serious healthcare problem .'],
 'healing': ['The main problem with surgery is that clubfoot wounds heal by a patching up process called repair .',
  'A major problem associated with chronic wounds is that they are easily prone to infections .',
  'A problem with the acute TM perforation model is that most acute TM perforations will heal spontaneously , both in animals and human beings .',
  'However , a major drawback of TES products is a lack of skin appendages and nerves to enhance skin healing , structural integrity and skin vitality .',
  'Skin regeneration is a vexing problem in the field of regenerative medicine .',
  'Wound infection is a serious problem in the home care patient .',
  'Skin disease continues to be a vexing problem for amputees and those who care for them .',
  'Impaired wound healing is a serious concern of uncontrolled hyperglycemia that can lead to gangrene , and even death .',
  'The risk of infection is higher and infections are a serious clinical problem in patients with type 1 ( insulin-dependent ) diabetes mellitus ( T1DM ) .',
  'Diabetes mellitus is a serious public health problem in which a major complication is impaired wound healing .',
  'Wound healing is still a serious medical problem due to process complexity and lack of effective medicaments .',
  'Osseous reconstruction is an important component in ulcer healing and prevention ; however , despite such efforts , major LEAs remain a serious postreconstruction concern .',
  'For hundreds of years poor and chronic nonhealing wounds have constituted a serious problem to medicine .',
  'Chronic wounds represent a serious problem in daily medical routine requiring improved wound care .',
  'Chronic wounds are still regarded as a serious public health concern , which are on the increase mainly due to the changes in life styles and aging of the human population .',
  'Skin tears are a serious , painful problem for older patients .',
  'Chronic wounds represent a serious problem for patients in terms of quality of life , lost employment time , and loss of income .',
  'The unknown mechanisms of impaired tissue repair in diabetes mellitus are making this disease a serious clinical problem for the physicians worldwide .',
  'Wound care is a serious healthcare concern , often complicated by prolonged inflammation and bacterial infection , which contributes significantly to mortality and morbidity .',
  'Wound pain is a serious problem for people with chronic wounds .',
  'Chronic dermal wounds are a devastating problem , which disproportionally affect individuals with conditions such as diabetes , paralysis , or simply old age .',
  'Delayed repair is a serious public health concern for diabetic populations .',
  'Since wound healing represents a severe problem in equine dermatology , our data may be essential for the establishment of new and improved therapy .',
  'Chronic wounds are a serious problem that could cause severe morbidity and even death .',
  'Corticosteriods have been shown to impair wound healing , which has become a serious clinical problem in wound care .',
  'Wound infection is a serious clinical problem , and the most common infection-causing bacteria are Staphylococcus aureus and Pseudomonas aeruginosa .',
  'Impaired diabetic wound healing represents a devastating and rapidly growing clinical problem associated with high morbidity , mortality , and recurrence rates .',
  'Alterations in skin integrity represent a serious problem in the pediatric inpatient setting .',
  'Chronic wounds are a significant cause of morbidity and mortality for many patients and therefore constitute a serious clinical concern .',
  'Disorders of wound healing characterized by impaired or delayed re-epithelialization are a serious medical problem .',
  'Chronic wounds constitute a debilitating health care problem with significant clinical and social implications .',
  'Diabetes-related chronic cutaneous lesions are a serious and common problem , as well as a major cause for hospital admissions , although no general consensus has been reached on the best available treatment for this frequent pathological condition .',
  'Impaired wound healing is a serious problem for diabetic patients .',
  'Wounds continue to be a serious medical concern due to their increasing incidence from injuries , surgery , burns and chronic diseases such as diabetes .',
  'The biological process of wound healing is one of the most complex occurrences during our lives turning a serious public health problem .',
  'Abolished or delayed wound healing is a serious problem in clinical surgery , therefore , the new therapy for wound healing is needed .',
  'Wound healing is a troublesome problem in diabetic patients .',
  'Recently , despite the current medical progress , the chronic and non-healing wounds still represent a serious medical problem .',
  'Delayed wound healing is a serious clinical problem in patients after surgery .',
  'Troubles can arise during the re-epithelialization phase of skin wound healing particularly in keratinocyte migration , resulting in chronic non-healing lesions , which represent a serious clinical problem .',
  'Skin wound healing is a serious clinical problem especially after surgery and severe injury of the skin .',
  'Impaired wound healing is a complication of diabetes and is a serious problem in clinical practice .',
  'Wounds , burns , cuts , and scarring may cause a serious problem for human health if left untreated , and medicinal plants are identified as potentially useful for wound healing .',
  'A serious obstacle towards widespread use of stem cells for tissue regeneration is the challenges that face these cells when they are placed in vivo into a wound for therapy .',
  'Impaired wound healing is a complication of diabetes and a serious problem in clinical practice .',
  'In diabetic patients , impairment of wound healing is a serious problem which represents a significant health burden .',
  'Progressive antibiotic resistance is a serious condition adding to the challenges associated with skin wound treatment , and antibacterial wound dressings with alternatives to antibiotics are urgently needed .',
  'Chronic or non-healing wounds are a serious problem for both the parties involved and the healthcare system .',
  'Chronic nonhealed wound after below-knee amputation is a serious problem that is faced by the health care team ; therefore , there is a need to find an adjuvant therapy to address this problem .',
  'Chronic infected non-healing wounds represent a serious concern for health care systems .',
  'Chronic wounds constitute a serious public health problem , and developing pharmaceutical dosage forms to ensure patient comfort and safety , as well as optimizing treatment effectiveness , are of great interest in the pharmaceutical , medical and biomaterial fields .',
  'Woundhealing disorders characterized by impaired or delayed re-epithelialization are a serious medical problem that is painful and difficult to treat .',
  'Chronic wounds seem to be a severe problem in terms of its socioeconomical meaning due to the fact that the average age of patients suffering from these wounds is rising steadily .',
  'Chronic wounds seem to be a severe problem in terms of socioeconomical meanings due to the fact , that the average age of patients suffering from these wounds rises steadily .',
  'Treatment of non-healing wounds represents hitherto a severe dilemma because of their failure to heal caused by repeated tissue insults , bacteria contamination and altered physiological condition .',
  'Disorders of wound healing characterized by impaired or delayed re-epithelialization are a serious medical problem .',
  'Wound healing impairment is a serious problem in surgical disciplines which may be associated with chronic morbidity , increased cost and patient discomfort .',
  'Prolonged healing is a severe problem for elderly and diabetic patients .',
  'SSFN may be a serious factor in observations of impaired wound healing among obese subjects , a particularly worrisome problem in an obese aging population given the propensity for small fiber impairment in aging subjects .',
  'Management of skin wound infections presents a serious problem in the clinic , in the community , and in both civilian and military clinical treatment centers .',
  'Wound healing disorders characterised by impaired or delayed reepithelialisation are a serious medical problem .',
  'Despite recent advances in bioengineered therapies , wound healing remains a serious clinical problem .',
  'Despite the development of advanced antibacterial materials , bacterial infection is still a serious problem for wound healing because it usually induces severe complications and can not be eradicated completely .',
  'Contracture of split skin grafts in burns injuries remains a serious problem and this in vitro model provides an opportunity to study keratinocyte/mesenchymal cell interactions and cell interactions with extracted normal human dermis .',
  'Non-healing wounds are a serious social and economic problem for patients .',
  'Chronic wounds are a serious healthcare problem .'],
 'pylori': ['The worst problem with H. pylori chemotherapy is that even if we identify the most successful regimen , it can not eliminate the risk of re-infection .',
  'A drawback of rifaximin could be its inability to reach sufficiently high concentrations in the gastric mucus layer under and within which H. pylori is commonly located and this would likely affect eradication rate .',
  'However , resistance to CAM is increasing in H. pylori and is becoming a serious problem in H. pylori eradication therapy .',
  'Resistance to antibiotics in Helicobacter pylori is increasing and becoming a serious problem in eradication treatment .',
  'Modern triple drug regimens are highly effective for treating Helicobacter pylori infection , but bacterial resistance to one of the most effective antibiotics , metronidazole , is a serious and increasing problem .',
  'Antimicrobial resistance in Helicobacter pylori is a serious and increasing problem , and the development of rapid , reliable methods for detecting resistance would greatly improve the selection of antibiotics used to treat gastric infection with this organism .',
  'Increasing resistance to drugs represents a serious problem in treatment of infections with Helicobacter pylori , providing cause of frequent therapeutic failures .',
  'In Vietnam , the high prevalence of Helicobacter pylori infection represents a serious health problem .',
  'Clarithromycin resistance of Helicobacter pylori is a serious problem in eradication therapy .',
  'Gastric ulcerations in the region of antrum pylori represent a serious medical problem in humans and animals .',
  'Since the acquisition by H. pylori of resistance to antibiotics has become a serious problem , tea and tea catechins may be very safe resources to control H. pylori-associated gastroduodenal diseases .',
  'The aim of the present study was to identify whether H. pylori infection influences the prevalence of allergic rhinitis , which has become a serious social problem , especially in the developed countries .',
  'The link between H. pylori and , ulceration as well as its association with the development of both gastric cancer and mucosa-associated lymphoid tissue lymphoma in humans is a serious public health concern .',
  'Although modern triple-drug regimens are usually highly effective in the treatment of H. pylori infection , the emergence of resistance to two of the most used antibiotics , metronidazole ( Mtz ) and clarithromycin ( Cla ) , is a serious and increasing problem .',
  'Recently , the acquisition by Helicobacter pylori of resistance to antibiotics has become a serious problem .',
  'After the eradication of Helicobacter pylori infection , relapse is a serious problem in Turkey .',
  'H. pylori infection is a serious public health problem , and thus the presence of H. pylori infection justifies treatment .',
  'Resistance to antibiotics in Helicobacter pylori is increasing and becoming a serious problem in eradication treatment of H. pylori .',
  'Guidelines published in 1990 by an international working party during the World Congress of Gastroenterology recommended H. pylori eradication only in patients where duodenal ulcer was a serious management problem requiring lifelong maintenance therapy , and in whom complications ( bleeding , perforation ) had occurred or surgery was considered ( Tytgat et al , 1990 ) .',
  'Since antibiotic-resistant strains of H. pylori have become a serious problem , nonantibiotic urease inhibitors may be very useful to control H. pylori-associated gastroduodenal disease .',
  'Helicobacter pylori is a cause of chronic gastritis , peptic ulcer disease , and gastric malignancy , infection being a serious health problem in Thailand .',
  'Helicobacter pylori ( H. pylori ) infection as a serious problem in both adults and children can induce chronic gastritis , peptic ulcer disease ( PUD ) , and possibly gastric cancer .',
  'The recent increase in resistant strains of Helicobacter pylori has become a serious problem .'],
 'helicobacter': ['The worst problem with H. pylori chemotherapy is that even if we identify the most successful regimen , it can not eliminate the risk of re-infection .',
  'A drawback of rifaximin could be its inability to reach sufficiently high concentrations in the gastric mucus layer under and within which H. pylori is commonly located and this would likely affect eradication rate .',
  'However , resistance to CAM is increasing in H. pylori and is becoming a serious problem in H. pylori eradication therapy .',
  'Resistance to antibiotics in Helicobacter pylori is increasing and becoming a serious problem in eradication treatment .',
  'Modern triple drug regimens are highly effective for treating Helicobacter pylori infection , but bacterial resistance to one of the most effective antibiotics , metronidazole , is a serious and increasing problem .',
  'Antimicrobial resistance in Helicobacter pylori is a serious and increasing problem , and the development of rapid , reliable methods for detecting resistance would greatly improve the selection of antibiotics used to treat gastric infection with this organism .',
  'Increasing resistance to drugs represents a serious problem in treatment of infections with Helicobacter pylori , providing cause of frequent therapeutic failures .',
  'In Vietnam , the high prevalence of Helicobacter pylori infection represents a serious health problem .',
  'Clarithromycin resistance of Helicobacter pylori is a serious problem in eradication therapy .',
  'Gastric ulcerations in the region of antrum pylori represent a serious medical problem in humans and animals .',
  'Since the acquisition by H. pylori of resistance to antibiotics has become a serious problem , tea and tea catechins may be very safe resources to control H. pylori-associated gastroduodenal diseases .',
  'The aim of the present study was to identify whether H. pylori infection influences the prevalence of allergic rhinitis , which has become a serious social problem , especially in the developed countries .',
  'The link between H. pylori and , ulceration as well as its association with the development of both gastric cancer and mucosa-associated lymphoid tissue lymphoma in humans is a serious public health concern .',
  'Although modern triple-drug regimens are usually highly effective in the treatment of H. pylori infection , the emergence of resistance to two of the most used antibiotics , metronidazole ( Mtz ) and clarithromycin ( Cla ) , is a serious and increasing problem .',
  'Recently , the acquisition by Helicobacter pylori of resistance to antibiotics has become a serious problem .',
  'After the eradication of Helicobacter pylori infection , relapse is a serious problem in Turkey .',
  'H. pylori infection is a serious public health problem , and thus the presence of H. pylori infection justifies treatment .',
  'Resistance to antibiotics in Helicobacter pylori is increasing and becoming a serious problem in eradication treatment of H. pylori .',
  'Guidelines published in 1990 by an international working party during the World Congress of Gastroenterology recommended H. pylori eradication only in patients where duodenal ulcer was a serious management problem requiring lifelong maintenance therapy , and in whom complications ( bleeding , perforation ) had occurred or surgery was considered ( Tytgat et al , 1990 ) .',
  'Since antibiotic-resistant strains of H. pylori have become a serious problem , nonantibiotic urease inhibitors may be very useful to control H. pylori-associated gastroduodenal disease .',
  'Helicobacter pylori is a cause of chronic gastritis , peptic ulcer disease , and gastric malignancy , infection being a serious health problem in Thailand .',
  'Helicobacter pylori ( H. pylori ) infection as a serious problem in both adults and children can induce chronic gastritis , peptic ulcer disease ( PUD ) , and possibly gastric cancer .',
  'The recent increase in resistant strains of Helicobacter pylori has become a serious problem .'],
 'deficiency': ['One major problem with almost all human studies is that other micro- and macronutrient deficiencies are inadequately controlled for and thus it is often unclear as to whether reported abnormalities of immune function can be attributed specifically to iron deficiency .',
  'A significant problem in diagnosing infants and young children with iron deficiency ( ID ) and iron deficiency anemia ( IDA ) is that it is not clear how the biochemical markers used correspond to physiological outcomes such as growth , neurodevelopment and morbidity .',
  'In parallel , an increase in some pathological alterations caused by the deficit of some micronutrients present in dairy products , mainly calcium and vitamin D , has been detected , resulting in a serious public health problem in certain groups of population .',
  'Iron-deficiency anemia in pregnant women is a serious public health problem especially in tropical countries .',
  'In Peru , Honduras , Argentina , Ecuador , and Brazil , vitamin A deficiency is a moderate public health problem ( prevalence from 14.0 % to 17.4 % ) , while in Colombia , Mexico , and Haiti it is a severe public health problem ( prevalence from 24.3 % to 32.0 % ) .',
  'Iron-deficiency anaemia ( IDA ) is a serious health problem in neonatal piglets and is controlled by routine application of iron in various formulations .',
  'Our study shows that iodine deficiency is a serious problem among pregnant women in Edirne .',
  'Among mothers , 27 % had chronic energy deficiency ( body mass index , < 18.5 kg/m(2 ) ) and 20 % were night blind , indicating that vitamin A deficiency was a serious problem .',
  'Vitamin A deficiency is recognized to be a severe public health problem in most of the sahelian countries .',
  'Public health : Although the availability of vitamin A through food fortification and medicinal supplements virtually eliminated ocular vitamin A deficiency from developed countries by the second half of the 20th century , vitamin A deficiency remains a serious problem in developing countries as indicated by global surveys beginning in the 1960s .',
  'Iron deficiency is a serious problem around the world , especially in developing countries .',
  'Iron ( Fe ) chlorosis is a serious problem affecting the yield and quality of numerous crops and fruit trees cultivated in alkaline/calcareous soils .',
  'This dilemma represents a serious problem in many populations , for an association of vitamin D-deficiency and multiple independent diseases has been convincingly demonstrated .',
  '25-hydroxy vitamin D [ 25(OH ) vit D ] deficiency is a serious public health problem , particularly in the Indian sub-continent .',
  'Vitamin-A deficiency is a severe public health problem in the study area .',
  'Vitamin A deficiency ( VAD ) is a serious and widespread public health problem in developing countries .',
  'Several surveys conducted over a period of 40 years have shown that vitamin A deficiency is a serious public health problem in Ethiopia .',
  'According to international criteria , the national prevalence of marginal vitamin A status found in the survey identifies the country as having a serious public health problem of vitamin A deficiency .',
  'Vitamin D deficiency is a serious health problem among large population groups in Europe .',
  'Iodine deficiency disorders ( IDD ) constitute a severe public health problem in Sudan .',
  'Iron ( Fe ) is one of the most abundant elements on earth , but its limited bioavailability poses a major constraint for agriculture and constitutes a serious problem in human health .',
  'Our study revealed that iodine deficiency still remains a serious problem for pregnant women .',
  'This dilemma represents a serious problem in many populations , for an association of vitamin D-deficiency and multiple independent diseases including various types of cancer has been convincingly demonstrated .',
  'Iron deficiency anemia was considered a severe problem .',
  'Marginal vitamin A deficiency ( MVAD ) is a serious and widespread public health problem among pregnant women and children in developing countries .',
  'Iodine deficiency is a serious public health problem worldwide which is associated with mental retardation and cretinism .',
  'Vitamin D deficiency , a preventable disorder , is a common and important public health problem for older disabled women living in the community ; black women are at higher risk than are white women .',
  'However , iodine malnutrition is still a severe public health problem because some communities in this study such as in Kisoro still have low iodine consumption , while others such as Luwero now have iodine excess .',
  'Iodine-deficiency disorders have been a serious public health problem in Brazil because of the failure of a salt iodination programme established in 1953 .',
  'Vitamin A deficiency ( VAD ) is a serious and widespread public health problem and the leading cause of preventable blindness in young children .',
  'Anemia was a severe problem , affecting children with both stunting and overweight .',
  'Mild or marginal vitamin A deficiency ( MVAD ) is still a serious and widespread public health problem in pregnant women and children in developing countries .',
  'The study demonstrated that iodine deficiency is still a severe public health problem in Metekel Zone .',
  'Iron overload before the availability of epoetin constituted a serious problem ; our review of the literature does not decisively conclude that these patients had more serious bacterial infections or increased mortality when compared with their non-iron overloaded counterparts , unless chronic transfusion-related hepatic disease was superimposed .',
  'iron deficiency anemia is a serious health problem among children living in the marginalized areas of the Gaza Strip , which justifies the necessity for national intervention programs to improve the health status for the less fortunate development areas .',
  'Vitamin A insufficiency among Chongqing urban school-age children was found to be a severe health problem , significantly associated with obesity , hypertriglyceridemia and MS .',
  'Iron deficiency anaemia is a serious problem among Pakistani children .',
  'Vitamin D deficiency is a serious public health problem worldwide that affects not only skeletal health , but also a wide range of acute and chronic diseases .',
  'Iodine deficiency has been recognized as a severe public health concern in Ethiopia , however little is known about the problem .',
  'In sub-Saharan Africa , vitamin A deficiency constitutes a severe health problem despite various supplementation and food fortification programs .',
  'Elevated iodine intake is a serious problem in the diagnostic and therapeutic application of (131)iodine in patients with differentiated thyroid cancer .',
  'In particular , vitamin A deficiency , a severe health problem affecting the lives of millions in developing countries , has triggered the development of a series of high-provitamin A crops , including Golden Rice as the best-known example .',
  'Although Turkey is located in a sunny region , vitamin D deficiency is still a serious health problem in pregnant women and their infants , especially among the low socio-economic status Turkish population .',
  'Biochemical vitamin A deficiency ( VAD ) is believed to be a serious public health problem ( low serum retinol prevalence \xa0 > 20 % ) in Indian children , justifying universal high-dose vitamin A supplementation ( VAS ) .',
  'Chronic iodine deficiency was a severe public health problem in the study communities .',
  'Iron deficiency ( ID ) caused by blood loss and/or reduced iron absorption is a serious problem influencing health in inflammatory bowel disease ( IBD ) .',
  'Iron ( Fe ) is essential micronutrient for plants and its deficiency as well as toxicity is a serious agricultural problem .',
  'from this study demonstrated that vitamin A deficiency among children under 5 years old appeared to be a serious public health problem in the poor rural areas of 6 Western Chinese provinces .',
  'Vitamin A ( VA ) deficiency remains a serious problem in the world today .',
  'Vitamin D deficiency has been highlighted as a serious public health problem in the United Kingdom .',
  'Xerophthalmia due to vitamin A deficiency is a leading cause of blindness in children and has been a serious problem in Indonesia .',
  'In clinical practice , the problem is generally iron deficiency , iron overload generally not being a serious problem .',
  'The study of iron metabolism is essential in nutritional sciences as iron deficiency is one of the most common nutritional deficiencies in humans and represents a serious health problem worldwide .',
  'Vitamin A deficiency ( VAD ) is a serious and widespread public health problem in the Philippines .',
  'Vitamin D deficiency is becoming a serious public health problem , even in sun-drenched cities like Karachi , Pakistan .',
  'Vitamin A deficiency is a serious health problem in Bangladesh .',
  'The prevalence of vitamin A deficiency was 72 % , indicating a severe public health problem .',
  'That is why iron deficiency has a severe impact on the lives of different organisms , including humans , becoming a major concern , especially in developing countries where access to adequate nutrition is still difficult .',
  'Nutritional vitamin B₁₂ deficiency due to maternal deficiency might be a serious health problem in infants .',
  'These data suggest that Vitamin A deficiency is still a serious public health problem in rural areas of the Congo in which this study was carried out .',
  'Iron deficiency anemia is a serious health problem that affects the physical and cognitive development of children .',
  'Dietary vitamin B12 deficiency is a severe problem in the Indian subcontinent , Mexico , Central and South America , and selected areas in Africa .',
  'Vitamin A deficiency is still a serious public health problem affecting an estimated 127 million preschool children .',
  'Hemochromatosis is the archetype of genetic iron overload diseases and represents a serious health problem .',
  'Vitamin A deficiency is a serious problem throughout the developing world .',
  'The high prevalence of depleted iron stores in nulliparous women is a severe public health problem that requires attention .',
  'Vitamin D insufficiency could be a serious problem in patients with high dose glucocorticoid therapy .',
  'Iron deficiency chlorosis ( IDC ) is a serious environmental problem affecting the growth of several crops in the world .',
  'Recent national data indicated an inverse association between vitamin D status and coronary heart disease ( CHD ) , which increases concerns about vitamin D deficiency as a serious public health problem .',
  'Nutritional iron deficiency is still a severe public health problem even in what are considered to be developed regions .',
  'Manganese ( Mn ) and iron ( Fe ) are essential mineral micronutrients for plants and their deficiency and or toxicity represents a serious agricultural problem .',
  'The observational studies conducted by our group revealed that vitamin D insufficiency does not seem to be a serious problem among active elderly people , but that elderly people with a low level of activities of daily living ( ADL ) are at a very high risk of vitamin D insufficiency .',
  'Vitamin D insufficiency is a serious problem in the study population , and living near the Equator does not assure adequate vitamin D status .',
  'Our study shows that iodine deficiency is a serious problem among pregnant women in Ankara .',
  'Vitamin A deficiency is a serious global health problem that can be alleviated by improved nutrition .',
  'These data define vitamin A deficiency as a severe public health problem in the Bandiagara area of Mali .',
  'Thus , predominant rice consumption promotes vitamin A deficiency , a serious public health problem in at least 26 countries , including highly populated areas of Asia , Africa , and Latin America .',
  'Vitamin D deficiency is a preventable health problem .',
  'There is a serious public health problem of low vitamin D status .',
  'Iron deficiency anemia in childhood is a serious public health problem worldwide .',
  'In Zambia , iron deficiency anaemia was a serious problem among camp-restricted refugees .',
  'Among 8 studies on subclinical vitamin A deficiency , 7 of them indicated a severe public health problem ( > 20 % ) .',
  'The environmental iodine deficiency has been a serious problem in the Polish health care system for many years .',
  'Iodine deficiency in Israeli SAC and PW is a serious public-health concern .',
  'Vitamin A deficiency : a serious nutritional problem in many areas of the world today .',
  'Vitamin D deficiency is a serious global health problem .',
  'Ca deficiency was discovered to be a serious health problem for rural children , with Ca inadequacies reaching 96 % .',
  'Iron deficiency represents a serious health concern for women , particularly pregnant ones .',
  'The-findings of the present study indicated that as per clinical criteria of WHO/UNICEF/ICCIDD , IDD is a severe public health problem though apparently there is no biochemical iodine deficiency .',
  'In general , the study revealed that iodine deficiency disorder was a serious public health concern .',
  'Iron deficiency anemia ( IDA ) is a serious public health problem that debilitates ∼1.6 billion people globally every year , the majority being pregnant women and children from developing countries .',
  'There are few data derived from communities where iron and folate deficiency is common and anaemia is a serious health problem .',
  'There are few data derived from communities where iron deficiency is common and anaemia is a serious health problem .',
  'This dilemma represents a serious problem , for an association of vitamin D-deficiency and multiple independent diseases including various types of cancer , bone diseases , autoimmune diseases , infectious diseases , cardiovascular diseases and hypertension has now been reported in a large number of laboratory and epidemiologic investigations .',
  "Multiple micronutrient deficiencies , in particular iron deficiency anaemia ( IDA ) is a severe public health problem in Lao People 's Democratic Republic ( Lao PDR ) .",
  "With vitamin D deficiency as a serious public health problem , vitamin D status at birth was measured in neonates at latitude 32 degrees 72 ' ( southeastern United States ) .",
  'Iodine deficiency disorders ( IDD ) are a serious public-health problem in Bangladesh and in other countries .',
  "Xerophthalmia prevalence ranged from 1.6 % to 4.4 % for nightblindness and 0.6 % to 2.7 % for Bilot 's spots in the three provinces indicating a serious vitamin A deficiency problem .",
  'There are few data derived from communities where iron deficiency is common and anaemia is a serious health problem .',
  'There are few data derived from communities where iron and folate deficiency is common and anaemia is a serious health problem .',
  'Vitamin D deficiency is a serious health problem despite a general improvement in socio-economic status in Turkey .',
  'Iron deficiency is a serious agricultural problem , particularly in alkaline soils .',
  'Vitamin D deficiency is a serious health problem with numerous health consequences ; it is associated with diabetes , rheumatic arthritis , Parkinson , Alzheimer diseases , osteomalacia , osteoporosis , and fractures in adults and cancers .',
  'Our results indicate that although Isparta is a region with mild iodine deficiency , goiter prevalence remains a serious problem .',
  'Although large-scale salt iodination began long time ago , iodine deficiency is still a serious health problem among pregnant women .',
  'Vitamin A deficiency is a serious health problem in many developing countries .',
  'Vitamin D deficiency ( VDD ) is emerging as a serious public health problem globally ; however due to lack of resources , vitamin D levels are not routinely measured among neonates .',
  'The rise in maternal obesity highlights that maternal and newborn vitamin D deficiency will continue to be a serious public health problem until steps are taken to identify and treat low 25(OH)D.',
  'This dilemma represents a serious problem , for an association of vitamin D-deficiency and multiple independent diseases including various types of cancer , bone diseases , autoimmune diseases , infectious diseases , cardiovascular diseases and hypertension has now been reported in a large number of investigative and epidemiologic studies .',
  'On the other hand , vitamin D deficiency ( VDD ) is also a serious public health problem with significant impacts and multiple health effects .',
  'Vitamin A deficiency is a serious nutritional problem , causing multiple adverse health outcomes .',
  'Vitamin A deficiency was still a serious health problem in children in China cities .',
  'These results confirm the presence of a serious public health problem with regard to vitamin D amongst veiled women .',
  'Iodine deficiency disorders continue to be a severe problem in many parts of Central Asia , causing delayed mental development and cretinism in indigenous populations .',
  'Vitamin A ( VA ) deficiency is a serious public health problem , especially in preschool children who are at risk of increased mortality .',
  'Iron deficiency anemia is a severe public health problem in developing countries .',
  'This study is the first to show borderline iodine sufficiency in reproductive age Saudi women from the Western province , whereas mild iodine deficiency was observed in the pregnant population and could represent a serious public health problem .',
  'The severe deficiency of iron or ferric chlorosis is a serious problem of most citrus trees established in calcareous soils , as a result of the low availability of iron in these soils and the poor uptake and limited transport of this nutrient in trees .'],
 'anaemia': ['One major problem with almost all human studies is that other micro- and macronutrient deficiencies are inadequately controlled for and thus it is often unclear as to whether reported abnormalities of immune function can be attributed specifically to iron deficiency .',
  'A significant problem in diagnosing infants and young children with iron deficiency ( ID ) and iron deficiency anemia ( IDA ) is that it is not clear how the biochemical markers used correspond to physiological outcomes such as growth , neurodevelopment and morbidity .',
  'Iron-deficiency anemia in pregnant women is a serious public health problem especially in tropical countries .',
  'Anemia in children living at all three altitude categories is more than 40 % and a severe public health problem according to the World Health Organization .',
  'Anaemia was a severe public health problem and prevalence differed by residency and eco-region .',
  'Anemia was a severe public health problem in Guatemala , Haiti , and Bolivia .',
  '[ Sickle cell disease : a serious and unknown problem of public health in Brazil ]',
  'Iron-deficiency anaemia ( IDA ) is a serious health problem in neonatal piglets and is controlled by routine application of iron in various formulations .',
  'Iron deficiency is a serious problem around the world , especially in developing countries .',
  'Iron ( Fe ) chlorosis is a serious problem affecting the yield and quality of numerous crops and fruit trees cultivated in alkaline/calcareous soils .',
  'Anemia however is a serious public health problem affecting some 30 % of the subjects , with almost half due to ID .',
  'Anemia was found to be a severe public health problem in the study area .',
  'The high prevalence of anaemia indicates it is currently a serious health problem of pregnant women living in Gilgel Gibe Dam area .',
  'Iron ( Fe ) is one of the most abundant elements on earth , but its limited bioavailability poses a major constraint for agriculture and constitutes a serious problem in human health .',
  'Anemic conditions in women and children across the world are a serious cause for concern .',
  'Iron deficiency anemia was considered a severe problem .',
  'Anemia appears to be a serious public health problem among preschool children in the Sioux Lookout Zone .',
  "Anemia is a severe public health problem in the Lao People 's Democratic Republic ( PDR ) .",
  'Anaemia is a serious health problem in the contemporary world which aff ects 24.8 % of the total human population .',
  'Anemia was a severe problem , affecting children with both stunting and overweight .',
  'The prevalence of anemia is a severe public health problem among pregnant women of underprivileged ethnic groups in Province 2 .',
  'Iron overload before the availability of epoetin constituted a serious problem ; our review of the literature does not decisively conclude that these patients had more serious bacterial infections or increased mortality when compared with their non-iron overloaded counterparts , unless chronic transfusion-related hepatic disease was superimposed .',
  'iron deficiency anemia is a serious health problem among children living in the marginalized areas of the Gaza Strip , which justifies the necessity for national intervention programs to improve the health status for the less fortunate development areas .',
  'Anaemia is a severe public health problem among SAC and adolescents in rural Ghana irrespective of sex .',
  'Anaemia was found to be a severe public health problem in Lake Albert , affecting 68·9 % of children ( ninety-five percent confidence intervals ( 95 % CI ) 64·9 - 72·7 % ) , a statistically significant higher prevalence relative to the 27·3 % detected in Lake Victoria ( 95 % CI : 23·3 - 31·7 % ) .',
  'The prevalence of anaemia is a severe nutritional problem of public health significance .',
  'Anaemia is considered a serious public health problem in Egypt , although updated population-based data are lacking .',
  'The prevalence of anemia among adolescent girls is 47.9 % , of which 47.7 % have mild anemia , 51.7 % have moderate anemia , and 5.7 % have severe anemia , which reveals that anemia is a severe public health problem among adolescent girls in the study area .',
  'Iron deficiency anaemia is a serious problem among Pakistani children .',
  'Anemia is a serious health problem in Indian school children .',
  'To determine eight parameters of oxidative stress markers in erythrocytes from children with sickle cell disease and compare with the same parameters in erythrocytes from healthy children , since oxidative stress plays an important role in the pathophysiology of sickle cell disease and because this disease is a serious public health problem in many countries .',
  'Infantile anaemia has been a severe public health problem in China for decades .',
  'Anemia in children under-5 continues to be a severe public health problem in Ethiopia .',
  'Such findings are consistent with findings of other recent studies in poor , northwest areas of China and led to conclude that anaemia remains a serious health problem among children in parts of China .',
  'Anaemia is considered a severe public health problem by WHO and is seen as such in Ghana .',
  'Iron deficiency ( ID ) caused by blood loss and/or reduced iron absorption is a serious problem influencing health in inflammatory bowel disease ( IBD ) .',
  'However , even following this intervention anaemia remained a serious public health problem and additional work to define and evaluate an effective intervention package is warranted .',
  'Anaemia is a serious and common problem among young children in sub-Saharan Africa .',
  'Sickle cell disease is a serious public health problem in Gabon with a relatively high mortality rate .',
  'Iron ( Fe ) is essential micronutrient for plants and its deficiency as well as toxicity is a serious agricultural problem .',
  'This study has revealed that the prevalence of anemia in children less than five years is high and a severe public health problem in the study area .',
  'In clinical practice , the problem is generally iron deficiency , iron overload generally not being a serious problem .',
  'The study of iron metabolism is essential in nutritional sciences as iron deficiency is one of the most common nutritional deficiencies in humans and represents a serious health problem worldwide .',
  'Low coverage in receiving IFA supplement among adolescents is a serious concern for the success of anaemia reduction programme .',
  'Generally , the study showed that anemia was a severe public health problem among infants and young children in the study setting .',
  'Anemia is a severe global public health problem with serious consequences for both the human and socio-economic health .',
  'The prevalence of anemia in Nunavik women is similar to levels observed in non-industrialized countries and represents a severe public health problem that should be further investigated .',
  'However , anaemia in the third trimester is still a severe public health problem among pregnant women in these areas .',
  'Prevalence of anemia among children ( 6 - 23 \xa0 months ) was a severe public health problem in the study area .',
  'That is why iron deficiency has a severe impact on the lives of different organisms , including humans , becoming a major concern , especially in developing countries where access to adequate nutrition is still difficult .',
  'Anemia is considered a severe public health problem by World Health Organization when anemia prevalence is equal to or greater than 40 % in the population .',
  'Although it has declined in the past 13 years , anemia in women of childbearing age remains as a serious public health problem .',
  'Iron deficiency anemia is a serious health problem that affects the physical and cognitive development of children .',
  'Microcytic anaemia is getting to be a severe public health concern while malarial anaemia is a mild public health issue in children residing in urban areas of Mount Cameroon .',
  'Hemochromatosis is the archetype of genetic iron overload diseases and represents a serious health problem .',
  'Anemia is a serious public health concern especially in women of reproductive age ( WRA ) as it causes a high burden of morbidity and mortality and persists through intergenerational cycle .',
  'The high prevalence of depleted iron stores in nulliparous women is a severe public health problem that requires attention .',
  'Iron deficiency chlorosis ( IDC ) is a serious environmental problem affecting the growth of several crops in the world .',
  'Nutritional iron deficiency is still a severe public health problem even in what are considered to be developed regions .',
  'CONCLUSION : The high prevalence of anemia is regarded as a severe public health problem among preschool children in the city of Cuiabá .',
  'Manganese ( Mn ) and iron ( Fe ) are essential mineral micronutrients for plants and their deficiency and or toxicity represents a serious agricultural problem .',
  'Anaemia is known to have an impact on child development and mortality and is a severe public health problem in most countries in sub-Saharan Africa .',
  'Anemia among hospitalized children in this study was found to be a severe public health problem .',
  'Anemia among Haitian young children and women of childbearing age is a severe public health problem .',
  'These data show that anemia is a serious problem among children from low-income families and suggest that government nutrition programs such as food stamps and WIC are not meeting the needs of these children .',
  "Yet , in many countries a complete management of Cooley 's anaemia is today not feasible for economic or cultural reasons , and this disease remains a serious public health problem .",
  'According to the WHO classification , the overall prevalence of anemia was a severe public health problem .',
  'Iron deficiency anemia in childhood is a serious public health problem worldwide .',
  'In Zambia , iron deficiency anaemia was a serious problem among camp-restricted refugees .',
  'In conclusion , anemia is a severe public health problem in the Miti-Murhesa health zone , but NIDA is mostly predominant and needs to be further studied .',
  'Anemia prevalence in childhood was found to be a serious public health problem in this municipality .',
  'Childhood anaemia in Ethiopia is a severe public health problem .',
  'Childhood anaemia is considered a severe public health problem in most countries of sub-Saharan Africa .',
  'Anaemia is associated with poor health outcomes and is considered a serious public health problem particularly in low- and middle-income countries .',
  'Iron deficiency represents a serious health concern for women , particularly pregnant ones .',
  'Iron deficiency anemia ( IDA ) is a serious public health problem that debilitates ∼1.6 billion people globally every year , the majority being pregnant women and children from developing countries .',
  'There are few data derived from communities where iron and folate deficiency is common and anaemia is a serious health problem .',
  'There are few data derived from communities where iron deficiency is common and anaemia is a serious health problem .',
  'The results indicate that anemia is a serious public health problem in Jamaica .',
  "Multiple micronutrient deficiencies , in particular iron deficiency anaemia ( IDA ) is a severe public health problem in Lao People 's Democratic Republic ( Lao PDR ) .",
  'There are few data derived from communities where iron deficiency is common and anaemia is a serious health problem .',
  'Anaemia is a severe public health problem amongst all vulnerable age groups in India .',
  'Anemia has been identified as a severe public health concern among young children in India , however , information on the prevalence of anemia attributed to micronutrient deficiencies is lacking .',
  'There are few data derived from communities where iron and folate deficiency is common and anaemia is a serious health problem .',
  'In the rural areas in southern Shaanxi Province , anemia in infants aged 6 - 12 months is still a serious public health problem .',
  'Anemia is a serious public health problem in Indian school children .',
  'Iron deficiency is a serious agricultural problem , particularly in alkaline soils .',
  'Anemia is a serious Public Health problem .',
  'Anemia is a serious concern among indigenous populations in North America , and it appears to be widespread among the Inuit despite abundant intakes of heme iron .',
  'Anaemia was found to be a severe public health problem ( defined as > 40 % anaemic ) in five African countries for children aged 7 - 11 years and in four of the same countries for children aged 12 - 14 years .',
  'Anaemia should be considered a serious public-health concern in Cape Verde , mainly for chil- dren below 24 months .',
  'Lay summaryIn India , anemia is a serious public health problem , where 58 % of the children aged 6 - 59 \u2009 months are anemic .',
  'Anemia in kala-azar patients is a serious problem .',
  "However , prevalence of anemia suggests a serious public health problem among women and children , especially in Za'atri camp .",
  'Anemia in children and women is a severe public health problem in Sierra Leone .',
  "The results showed a significant presence of G-6-PD deficiency with predominance of a severe G-6-PD deficiency type in these blood donors in Sana'a City , which could represent an important health problem through occurrence of hemolytic anemia under oxidative stress .",
  'Iron deficiency anemia is a severe public health problem in developing countries .',
  'The severe deficiency of iron or ferric chlorosis is a serious problem of most citrus trees established in calcareous soils , as a result of the low availability of iron in these soils and the poor uptake and limited transport of this nutrient in trees .'],
 'insecticides': ['The problem these scientists are grappling with , however , is that insects that are easily mass-produced are not the insects people typically want to eat .',
  'The evolution of resistance to insecticides , such as organophosphates ( OPs ) , is a serious and growing concern .',
  '[ Resistance of lice to insecticides : a serious public health problem ] .',
  'Overuse of broad-spectrum insecticides for diamondback moth control is a serious problem and has obscured the contributions of indigenous parasitoids .',
  'Black flies , a non-target species of the insecticides used in fruit production , represent a severe medical and veterinary problem .',
  'Emergence and spread of resistance among vectors toward different insecticides is a serious problem for the Japanese encephalitis ( JE ) control program .',
  "Here , the term SHOCK ( Sudden , High-magnitude Opportunity for a Catastrophic ' Kick ' ) is used to encompass attributes of extreme events that carry the potential to add additional challenges to insect communities already facing environmental stressors .",
  'Insecticide resistance is a serious concern in modern agriculture , and an understanding of the underlying evolutionary processes is pivotal to prevent the problem .',
  'Insecticide resistance in Ae . aegypti is a serious problem facing control operations , and integrated control strategies are recommended to help prevent or delay the temephos resistance in larvae and pyrethroids resistance in adults .',
  'Since there is no effective control application against this pest , it has been a serious problem up to now .',
  'However , the harmful effects of insecticides against beneficial Insects continuous to be a serious problem .',
  'A serious shortcoming of many insecticides is that they can kill non-target species .',
  'Insecticide resistance is a serious problem that negatively impacts food production , food storage , human health , and the environment .',
  'Control of Frankliniella occidentalis ( Pergande ) is a serious problem for agriculture all over the world because of the limited range of insecticides that are available .',
  'Insecticide resistance is a serious economic problem that jeopardizes sustainability of chemical control of herbivorous insects and related arthropods .',
  'The rapid development of chemical pesticide resistance has become a severe problem in controlling pear psylla .',
  'There are a number of insecticides used for their management , but development of resistance is a serious problem .',
  'Genetically modified ( GM ) foods , while initially developed to tolerate herbicides and resist disease and insects , have the potential to help alleviate this issue that is currently posing a serious public health concern .',
  'Acaricide resistance is a serious problem in spider mites .',
  'Resistance to these insecticides in Aedes aegypti is a serious problem for the control of this species therefore integrated management strategies were proposed to prevent or delay the appearance of this species in Cuba and Venezuela .',
  'The development of insecticide resistance in the German cockroach , Blattella germanica ( L. ) is a serious problem in controlling this medically important household pest .',
  'Insecticide resistance in malaria vector mosquitoes presents a serious problem for those involved in control of this disease .',
  'Pesticide resistance poses a serious problem for worldwide mosquito control programs .',
  'Insecticide resistance is a serious problem facing the effective control of insect vectors of disease .',
  'Insecticide resistance has become a serious concern in controlling the insect vectors of public health importance .',
  'Frankliniella occidentalis ( Pergande ) is among the most important crop pests in the south-east region of Spain ; its increasing resistance to insecticides constitutes a serious problem , and understanding the mechanisms involved is therefore of great interest .',
  'The development of resistance against drugs most commonly used to treat salmon lice is a serious concern for both wild and farmed fish .',
  'Nylanderia pubens ( Forel ) is an invasive ant species that in recent years has developed into a serious nuisance problem in the Caribbean and United States .',
  'Pesticide resistance is a serious problem that poses a major challenge to pest control .',
  'Development of insecticide resistance has been a serious concern worldwide , whose mechanisms have been attributed to evolutionary changes in pest insect genomes such as alteration of drug target sites , up-regulation of degrading enzymes , and enhancement of drug excretion .',
  'It has not been detected in the United States yet , but given the extent of trade with Asian countries , eventual arrival of this beetle is a serious concern .',
  'Rhynchophorus ferrugineus ( Olivier 1790 ) ( Coleoptera : Curculionidae ) is becoming a serious problem in Mediterranean areas where it is well-adapted , and now is present even in the United States ( California ) .',
  'The evolution of insecticide resistance in Nilaparvata lugens has become a serious problem in the effective control of this pest in the paddy field .',
  'Cross-resistance between insecticides , especially from different groups , can be extremely unpredictable , and it has been a serious concern in pest control .',
  'The tropical fire ant , S. geminata , has become a serious problem in some areas of the Pacific and South Asia , especially Okinawa and Guam .',
  'The high level of pyrethroid resistance in this population despite the cessation of pyrethroid use for IRS in 1999 is a serious concern for resistance management strategies such as rotational use of insecticides .',
  'The recent emergence of heritable high level resistance to phosphine in stored grain pests is a serious concern among major grain growing countries around the world .',
  'The navel orangeworm , Amyelois transitella ( Walker ) ( Lepidoptera : Pyralidae ) , is the most destructive lepidopteran pest of almonds [ Prunus dulcis ( Mill . ) D.A.Webb ] and pistachios ( Pistacia vera L. ) in California and is a serious problem in figs ( Ficus carica L. ) and walnuts ( Juglans spp . ) .',
  'These results indicate that , although resistance is a serious problem in this species , satisfactory control should be possible by selection of an appropriate insecticide .',
  'Insecticide resistance has recently become a serious problem in the agricultural field .',
  'Because of this , control of ryegrass staggers by elimination of endophyte-infected ryegrass is not feasible in areas in which insect predation is a serious pasture problem .',
  'Tsetse flies with SGH have reduced fecundity and fertility which cause a serious problem for mass rearing in the frame of sterile insect technique ( SIT ) programmes to control and eradicate tsetse populations in the wild .',
  'Anthracnose is a serious problem of both Andean lupine and tamarillo in Ecuador .',
  'Difficulty in keeping insects alive or unavailability of liquid nitrogen or dry ice at regular intervals during extended collection trips poses a serious problem .',
  'The invasive brown marmorated stink bug , Halyomorpha halys ( Stål ) , has become a severe agricultural pest and nuisance problem since its introduction in the U.S. Research is being conducted to understand its biology and to find management solutions .',
  'Hypersensitivity to the imported fire ant continues to be a serious problem in the southern United States and appears to be amenable to properly instituted hyposensitization therapy .',
  'Its increasing resistance to insecticides constitutes a serious problem , and understanding the mechanisms involved is therefore of great interest .',
  'However , insect resistance to dichlorodiphenyltrichloroethane and restrictions on dichlorodiphenyltrichloroethane use due to its long-term environmental effects are factors in the persistence of malaria as a serious health problem .',
  "The coffee berry borer , Hypothenemus hampei Ferrari , is a serious problem for the majority of the world 's coffee growers and has proved to be one of the most intractable of present day pests .",
  'Insecticide resistance is a serious problem for vector control programmes worldwide .',
  'The Tea Shot Hole Borer ( TSHB ) is an ambrosia beetle from Asia that forms a symbiosis with a new , yet undescribed Fusarium sp. and is a serious problem for the Israeli avocado industry ( 3 ) .',
  'Megaplatypus mutatus ( Coleoptera : Platypodinae ) is an ambrosia beetle native to South America that only attacks standing live trees and is a serious problem for commercial poplar ( Populus L. ; Salicaceae ) plantations in Argentina .',
  'Resistance to insecticides by modification of their molecular targets is a serious problem in chemical control of many arthropod pests .',
  'The development of pyrethroid resistance in Aedes aegypti ( L ) ( Diptera : Culicidae ) is a serious concern because major A. aegypti control programs are predominantly based on pyrethroid use during epidemic disease outbreaks .',
  'The development of insecticide resistance is a serious problem in controlling of this pest .',
  'Head lice infestation ( HLI ) is a vexing problem for pediatricians and families because lice are becoming resistant to approved antipediculosis agents .',
  "Population explosions of the stable fly ( Stomoxys calcitrans ) have become a serious concern for livestock producers near sugarcane mills in some regions of Brazil due to the insect 's massive reproduction on sugarcane byproducts and waste ."],
 'insecticide': ['The problem these scientists are grappling with , however , is that insects that are easily mass-produced are not the insects people typically want to eat .',
  'The evolution of resistance to insecticides , such as organophosphates ( OPs ) , is a serious and growing concern .',
  '[ Resistance of lice to insecticides : a serious public health problem ] .',
  'Overuse of broad-spectrum insecticides for diamondback moth control is a serious problem and has obscured the contributions of indigenous parasitoids .',
  'Black flies , a non-target species of the insecticides used in fruit production , represent a severe medical and veterinary problem .',
  'Emergence and spread of resistance among vectors toward different insecticides is a serious problem for the Japanese encephalitis ( JE ) control program .',
  "Here , the term SHOCK ( Sudden , High-magnitude Opportunity for a Catastrophic ' Kick ' ) is used to encompass attributes of extreme events that carry the potential to add additional challenges to insect communities already facing environmental stressors .",
  'Insecticide resistance is a serious concern in modern agriculture , and an understanding of the underlying evolutionary processes is pivotal to prevent the problem .',
  'Insecticide resistance in Ae . aegypti is a serious problem facing control operations , and integrated control strategies are recommended to help prevent or delay the temephos resistance in larvae and pyrethroids resistance in adults .',
  'Since there is no effective control application against this pest , it has been a serious problem up to now .',
  'However , the harmful effects of insecticides against beneficial Insects continuous to be a serious problem .',
  'A serious shortcoming of many insecticides is that they can kill non-target species .',
  'Insecticide resistance is a serious problem that negatively impacts food production , food storage , human health , and the environment .',
  'Control of Frankliniella occidentalis ( Pergande ) is a serious problem for agriculture all over the world because of the limited range of insecticides that are available .',
  'Insecticide resistance is a serious economic problem that jeopardizes sustainability of chemical control of herbivorous insects and related arthropods .',
  'The rapid development of chemical pesticide resistance has become a severe problem in controlling pear psylla .',
  'There are a number of insecticides used for their management , but development of resistance is a serious problem .',
  'Genetically modified ( GM ) foods , while initially developed to tolerate herbicides and resist disease and insects , have the potential to help alleviate this issue that is currently posing a serious public health concern .',
  'Acaricide resistance is a serious problem in spider mites .',
  'Resistance to these insecticides in Aedes aegypti is a serious problem for the control of this species therefore integrated management strategies were proposed to prevent or delay the appearance of this species in Cuba and Venezuela .',
  'The development of insecticide resistance in the German cockroach , Blattella germanica ( L. ) is a serious problem in controlling this medically important household pest .',
  'Insecticide resistance in malaria vector mosquitoes presents a serious problem for those involved in control of this disease .',
  'Pesticide resistance poses a serious problem for worldwide mosquito control programs .',
  'Insecticide resistance is a serious problem facing the effective control of insect vectors of disease .',
  'Insecticide resistance has become a serious concern in controlling the insect vectors of public health importance .',
  'Frankliniella occidentalis ( Pergande ) is among the most important crop pests in the south-east region of Spain ; its increasing resistance to insecticides constitutes a serious problem , and understanding the mechanisms involved is therefore of great interest .',
  'The development of resistance against drugs most commonly used to treat salmon lice is a serious concern for both wild and farmed fish .',
  'Nylanderia pubens ( Forel ) is an invasive ant species that in recent years has developed into a serious nuisance problem in the Caribbean and United States .',
  'Pesticide resistance is a serious problem that poses a major challenge to pest control .',
  'Development of insecticide resistance has been a serious concern worldwide , whose mechanisms have been attributed to evolutionary changes in pest insect genomes such as alteration of drug target sites , up-regulation of degrading enzymes , and enhancement of drug excretion .',
  'It has not been detected in the United States yet , but given the extent of trade with Asian countries , eventual arrival of this beetle is a serious concern .',
  'Rhynchophorus ferrugineus ( Olivier 1790 ) ( Coleoptera : Curculionidae ) is becoming a serious problem in Mediterranean areas where it is well-adapted , and now is present even in the United States ( California ) .',
  'The evolution of insecticide resistance in Nilaparvata lugens has become a serious problem in the effective control of this pest in the paddy field .',
  'Cross-resistance between insecticides , especially from different groups , can be extremely unpredictable , and it has been a serious concern in pest control .',
  'The tropical fire ant , S. geminata , has become a serious problem in some areas of the Pacific and South Asia , especially Okinawa and Guam .',
  'The high level of pyrethroid resistance in this population despite the cessation of pyrethroid use for IRS in 1999 is a serious concern for resistance management strategies such as rotational use of insecticides .',
  'The recent emergence of heritable high level resistance to phosphine in stored grain pests is a serious concern among major grain growing countries around the world .',
  'The navel orangeworm , Amyelois transitella ( Walker ) ( Lepidoptera : Pyralidae ) , is the most destructive lepidopteran pest of almonds [ Prunus dulcis ( Mill . ) D.A.Webb ] and pistachios ( Pistacia vera L. ) in California and is a serious problem in figs ( Ficus carica L. ) and walnuts ( Juglans spp . ) .',
  'These results indicate that , although resistance is a serious problem in this species , satisfactory control should be possible by selection of an appropriate insecticide .',
  'Insecticide resistance has recently become a serious problem in the agricultural field .',
  'Because of this , control of ryegrass staggers by elimination of endophyte-infected ryegrass is not feasible in areas in which insect predation is a serious pasture problem .',
  'Tsetse flies with SGH have reduced fecundity and fertility which cause a serious problem for mass rearing in the frame of sterile insect technique ( SIT ) programmes to control and eradicate tsetse populations in the wild .',
  'Anthracnose is a serious problem of both Andean lupine and tamarillo in Ecuador .',
  'Difficulty in keeping insects alive or unavailability of liquid nitrogen or dry ice at regular intervals during extended collection trips poses a serious problem .',
  'The invasive brown marmorated stink bug , Halyomorpha halys ( Stål ) , has become a severe agricultural pest and nuisance problem since its introduction in the U.S. Research is being conducted to understand its biology and to find management solutions .',
  'Hypersensitivity to the imported fire ant continues to be a serious problem in the southern United States and appears to be amenable to properly instituted hyposensitization therapy .',
  'Its increasing resistance to insecticides constitutes a serious problem , and understanding the mechanisms involved is therefore of great interest .',
  'However , insect resistance to dichlorodiphenyltrichloroethane and restrictions on dichlorodiphenyltrichloroethane use due to its long-term environmental effects are factors in the persistence of malaria as a serious health problem .',
  "The coffee berry borer , Hypothenemus hampei Ferrari , is a serious problem for the majority of the world 's coffee growers and has proved to be one of the most intractable of present day pests .",
  'Insecticide resistance is a serious problem for vector control programmes worldwide .',
  'The Tea Shot Hole Borer ( TSHB ) is an ambrosia beetle from Asia that forms a symbiosis with a new , yet undescribed Fusarium sp. and is a serious problem for the Israeli avocado industry ( 3 ) .',
  'Megaplatypus mutatus ( Coleoptera : Platypodinae ) is an ambrosia beetle native to South America that only attacks standing live trees and is a serious problem for commercial poplar ( Populus L. ; Salicaceae ) plantations in Argentina .',
  'Resistance to insecticides by modification of their molecular targets is a serious problem in chemical control of many arthropod pests .',
  'The development of pyrethroid resistance in Aedes aegypti ( L ) ( Diptera : Culicidae ) is a serious concern because major A. aegypti control programs are predominantly based on pyrethroid use during epidemic disease outbreaks .',
  'The development of insecticide resistance is a serious problem in controlling of this pest .',
  'Head lice infestation ( HLI ) is a vexing problem for pediatricians and families because lice are becoming resistant to approved antipediculosis agents .',
  "Population explosions of the stable fly ( Stomoxys calcitrans ) have become a serious concern for livestock producers near sugarcane mills in some regions of Brazil due to the insect 's massive reproduction on sugarcane byproducts and waste ."],
 'antibodies': ['The problem with pure recombinant or synthetic antigens used in modern day vaccines is that they are generally far less immunogenic than older style live or killed whole organism vaccines .',
  'However , a serious problem associated with GM3 is that it is poorly immunogenic .',
  'Secondly , a major problem with the PCSK9 monoclonal antibodies is that they are expensive , and their use is often discontinued or not pursued , which can leave the subjects intended for treatment at high cardiovascular risk .',
  'A major problem with current cancer vaccines is that the induction of CD8 immune responses is rarely associated with antitumor benefits , mainly owing to multiple immune suppressions in established tumor lesions .',
  'A major problem with all current therapies for these diseases is that they target all antibodies rather than selectively targeting only pathogenic antibodies .',
  'A perceived problem with this approach is that the number of non-replicating viruses used as a vaccine inoculum does not remotely approximate the total number of cells in the body , nor even the number of tumour cells in the case of large tumour burden or metastasis .',
  'Another problem with preparing human hybridomas is that it is difficult to obtain B lymphocytes immunized with optional antigens for ethical reasons .',
  'A major problem with such an approach is that the genes coding for these proteins have a very rapid mutation rate , forcing commercial producers to wait for mutations to occur before developing effective new versions of standard vaccines .',
  'One potential problem with clinical melanoma vaccines against autologous tumors may be that often tumor cells do not express surface markers that label them for uptake by APC .',
  'A major problem with this approach is that it is likely that both the antibody and the toxin components of these conjugates will be immunogenic .',
  'Nevertheless , the main problem with the use of native cysticercal antigens is that the native proteins often show cross reactions with sera from humans infected with other parasites .',
  'A second problem with current FMD vaccines is that they do not induce protective immunity quickly , a drawback that is likely to be shared by our Ad5-vectored empty capsid vaccine .',
  'One problem encountered with classical DNA plasmid immunization is that peptides produced are noncovalently and transiently associated with MHC class I molecules and thus may not durably stimulate CD8(+ ) T cell responses .',
  'A major problem in treating hemophilia A patients with therapeutic factor VIII ( FVIII ) is that 20 % to 30 % of these patients produce neutralizing anti-FVIII antibodies .',
  'However a potential drawback of NS1 as a vaccine is that anti-DENV NS1 Abs can lead to endothelial cell damage and platelet dysfunction by antigenic cross-reactivity .',
  "However , the ' humanization ' of murine monoclonal antibodies ( mAbs ) is a time-consuming and expensive process that has the inherent drawback of potentially altering antigenic specificity and/or affinity .",
  'In addition , adsorbed molecules are stabilized and protected by the interaction with the spore , suggesting that this system could reduce the rapid degradation of the antigen , often observed with other delivery systems and identified as a major drawback of mucosal vaccines .',
  'Altogether , our results indicate a potential drawback of short peptide-based vaccination strategies and offer possible solutions regarding the use of problematic epitopes such as the one described here .',
  'A drawback of targeting soluble antigens such as cytokines or toxins with long-lived antibodies is that such antibodies can prolong the half-life of the target antigen by a " buffering " effect .',
  'A common drawback of many anti-idiotypic antibodies is their low immunogenicity .',
  'A major drawback of these proteins is the production of anti-drug antibodies ( ADAs ) .',
  'A drawback of this vaccine was a delay of about 8 weeks in buildup of antibody titers to efficacy level and the requirement of three injections of the vaccine given at monthly interval for full primary immunization .',
  'Each was applied to 90 % of the eligible population with differing assumptions about rates of compliance and seroconversion - problems of delivery ( obtaining high compliance ) was considered a significant drawback of targeted vaccination .',
  'Finally , the developed formulations should exhibit accuracy regarding the administered dose , a major drawback of mucosal vaccines in comparison with parenteral ones .',
  'Active vaccination inducing high-affinity antibodies against PCSK9 with less frequent administration intervals may be a novel promising therapeutic approach to overcome the drawback of passive immunization with PCSK9 mAb .',
  'A major drawback of subunit vaccines is their inability to generate cytolytic T lymphocytes ( CTL ) , a deficit attributed to segregation of the class I and class II antigen-processing pathways .',
  'Although DNA-based cancer vaccines have been successfully tested in mouse models , a major drawback of cancer vaccination still remains , namely that tumour antigens are weak and fail to generate a vigorous immune response in tumour-bearing patients .',
  'In addition , a major drawback of biopharmaceuticals is the risk of antibody formation .',
  'A drawback of biological treatment is immunogenicity and the development of antibodies directed against the drug [ anti-drug antibodies ( ADA ) ] , which are associated with a poorer clinical outcome .',
  'Their unique immunological properties offer new possibilities for the development of vaccines , which do not cause anaphylactic side effects , a major drawback of specific immunotherapy ( SIT ) .',
  'Moreover , CD38 and SLAMF7 targeting BiTEs , but not hemibodies induce massive cytokine release and T cell fratricide reactions , a major drawback of T cell recruiting strategies .',
  'However , pre-existing vector-specific immunity is frequently suggested to be a drawback of MVA-based vaccines .',
  'A drawback of current clinical trials is inadequate or lack of immune phenotyping of patients .',
  'A major drawback of In-111-labeled monoclonal antibodies ( MoAb ) is the presence of intense liver , renal , and bone marrow nonspecific activity .',
  'However , a drawback of DNA vaccines is their generally low immunogenicity in non-human primates and humans .',
  'However , a drawback of Ad vectors is diminished efficacy and toxicity that results from stimulation of innate and adaptive immunity .',
  'Reactivation : a severe problem in familial hemophagocytic lymphohistiocytosis .',
  'However , murine MoAbs induce human anti-mouse antibodies ( HAMAs ) , a serious problem for clinical use .',
  'Inhibitor antibody formation in patients with haemophilia receiving factor VIII ( FVIII ) concentrate is a serious problem .',
  'The production of factor VIII ( FVIII ) inhibitors is a serious problem of replacement therapy with FVIII concentrates in hemophiliacs .',
  'Inhibitor formation in haemophilia patients receiving factor VIII ( FVIII ) concentrate is a serious problem requiring tolerance induction therapy .',
  'However , a serious problem was detected in one laboratory where the sub-potent vaccine A could have been passed and was not distinguished from the eight-fold more potent vaccine B. There were also indications of possible problems in several other laboratories , where IHR preparation may not be accurately calibrated or where vaccine samples A and B may not be completely distinguished .',
  'Factor VIII (FVIII)-neutralizing antibodies ( " inhibitors " ) are a serious problem in hemophilia A ( HA ) .',
  'These preclinical results suggest that PCV7-TT will not result in a serious problem over the immune response elicited by the licensed vaccines Heberpenta ® -L and VA-MENGOC-BC ® .',
  'The declining sensitivity to these drugs is a serious therapeutic problem , while no safe and effective vaccine is likely to be available for general use in the near future .',
  'Development of inhibitors is a severe complication of haemophilia posing many management challenges .',
  'The development of an inhibitor in a hemophiliac is a serious clinical problem .',
  "Development of neutralizing anti-factor (F)VIII antibodies ( ' inhibitors ' ) is a serious clinical problem in hemophilia A. Increased inhibitor risk has been associated with certain FVIII missense substitutions , including R593C in the A2 domain .",
  'However , activation of the complement system , a complex innate immune network of over 30 circulating and membrane-bound proteins , remains a serious concern related to the use of these prospective neurological nanomedicines .',
  'The development of inhibitors to the infused factor in patients with haemophilia is a serious clinical problem .',
  'It is generally accepted that the difficulty in obtaining a sufficient number of functional dendritic cells ( DCs ) poses a serious problem in DC-based immunotherapy .',
  'Immunogenicity of biotherapeutics is a serious and growing concern for the US FDA and European Medicines Agency and will have significant and growing impact on the development and regulatory approval of both biosimilar and new innovator biotherapeutics .',
  'However , host antibody responses to the delivered antibody are a serious concern that could significantly limit the applicability of this approach .',
  'The production of factor VIII ( FVIII ) inhibitory antibodies is a serious problem in patients with hemophilia A. Immune tolerance induction ( ITI ) is the only strategy proven to eradicate persistent inhibitors and has been shown to be successful in 70 % of patients with hemophilia A. However , a minority of hemophilia patients present life-long inhibitors .',
  'Development of inhibitors to coagulation factors is a serious clinical problem in de-veloped countries and is more so in developing countries where treatment options are often limited .',
  'Although the antibodies cause a serious problem for affected individuals , they have been very useful in characterizing normal factor VIII and nonfunctional factor VIII-like protein that is found in the plasmas of 10 per cent of patients with mild hemophilia .',
  'It is generally accepted that the difficulty in obtaining a sufficient number of functional dendritic cells ( DCs ) is a serious problem in DC-based immunotherapy .',
  "Neutralizing antibodies ( NAbs ) against genetically engineered pharmaceuticals developed by the patient 's immune system , which reduce their therapeutic and biological activity , pose a serious problem .",
  'Human anti-murine antibody ( HAMA ) response is a serious problem in the repeated infusion of murine monoclonal antibodies ( MoAbs ) .',
  'Recently , occurrence of natural antibodies against Neu5Gc was shown in healthy humans and is a serious problem for clinical xenotransplantation and stem cell therapies .',
  'However , there remains a serious problem with regard to the stability and antibody production of the hybrid cell lines .',
  'The development of an inhibitor to transfused factor VIII ( FVIII ) is a serious treatment-related problem in haemophiliac children .',
  'Since development of inhibitory antibodies to FVIII is a serious problem in treatment of hemophilia A patients , we investigated the potential of this approach for inducing tolerance to FVIII in a hemophilia mouse model .',
  'In approximately 10 to 15 percent of congenital hemophilia A patients circulating antibodies to factor VIII appear in the blood that poses a serious problem in their treatment .',
  'However , a serious problem with them is the poor immunogenicity .',
  'Weak antibody responses to protein antigens after oral immunization remain a serious problem .'],
 'ks': ['A problem associated with probing measurement is that important site-specific change may be obscured by measurement variability .',
  'The main problem with this concept is that it is not directly accessible to experiments .',
  'The major limitation associated with analytical techniques is that they are often only applicable to problems with simplified assumptions .',
  'An important problem with the data is that results may be unphased with respect to their identification data for mechanical reasons .',
  'However , the problem with genome scans involving thousands of markers is that the statistic values of FAs can reach quite extreme magnitudes .',
  'However , a major drawback of these assays is that they are laborious and require large numbers of cells .',
  'A common drawback of most methodological approaches is that interpretation of experimental results is based on simplified theoretical models of blood .',
  'However , the necessity of having to conduct multiple experiments to test different scenarios is a major drawback of this approach .',
  'A major drawback of the empirically based Freundlich and Langmuir approaches is that their associated parameters are specific for each soil .',
  'A drawback of SWP is that it does not allow for temporal comparisons , because the measured value is impacted both by soil water availability and climatic conditions on the day of measurement .',
  'A serious drawback of the flux estimation method in current use is that it does not produce confidence limits for the estimated fluxes .',
  'A major drawback of this approach is the large number of false positive results .',
  'A major drawback of these methods is that if culturing is not performed properly , ambiguous results are produced .',
  'However , high-dimensionality in PLV data incurs a serious multiple testing problem .',
  'There was a serious problem of false positive results observed in the initial sideroom testing .',
  'Unfortunately , a serious technical problem for the SCM is the lack of the exact Kohn-Sham ( KS ) density rho KS(r ) required for the evaluation of the second-order correction .',
  'However , the accompanying increase in data dimensionality incurs a serious multiple testing problem for determining PLV significance .'],
 'counterfeit': ['One problem with such an approach is that the original buyer whose watermark has been found on unauthorized copies can claim that the unauthorized copy was created or caused ( for example , by a security breach ) by the original seller .',
  'Counterfeiting of drugs is a severe public health problem .',
  'Illicit sale of medicines is a serious public health problem in Africa .',
  'Pharmaceutical counterfeiting is becoming a serious problem both in developed and developing countries .',
  'Counterfeit medicines have become a serious global problem .',
  'Pharmaceutical counterfeiting is becoming a serious problem in the world , especially in developing countries including China .',
  'Various types of drugs have been counterfeited , posing a serious public health and safety problem .',
  'Medicines are expensive and hard to access in Yemen , and counterfeit medicines are a serious problem .',
  'This random survey confirms results from previous convenience surveys that counterfeit artesunate is a severe public health problem .',
  'Counterfeit and substandard antimalarial drugs have become a serious problem , which demands reliable analytical tools and implementation of strict regulation of drug quality .',
  "Available data about purities of drugs purchased in cryptomarkets suggest that adulteration is not a severe problem and this agrees with users ' perceptions .",
  'Counterfeit medicines are a serious public health problem in Peru .',
  'Counterfeit drugs are a menacing and deadly problem worldwide .',
  'Counterfeiting has become a serious and underreported problem in the pharmaceutical industry .',
  'Counterfeiting of pharmaceuticals has become a serious problem all over the world , particularly in developing countries .',
  'Chinese liquor is one of the famous distilled spirits and counterfeit liquor is becoming a serious problem in the market .',
  'The production and distribution of counterfeit pharmaceuticals present a serious problem worldwide .'],
 'counterfeiting': ['One problem with such an approach is that the original buyer whose watermark has been found on unauthorized copies can claim that the unauthorized copy was created or caused ( for example , by a security breach ) by the original seller .',
  'Counterfeiting of drugs is a severe public health problem .',
  'Illicit sale of medicines is a serious public health problem in Africa .',
  'Pharmaceutical counterfeiting is becoming a serious problem both in developed and developing countries .',
  'Counterfeit medicines have become a serious global problem .',
  'Pharmaceutical counterfeiting is becoming a serious problem in the world , especially in developing countries including China .',
  'Various types of drugs have been counterfeited , posing a serious public health and safety problem .',
  'Medicines are expensive and hard to access in Yemen , and counterfeit medicines are a serious problem .',
  'This random survey confirms results from previous convenience surveys that counterfeit artesunate is a severe public health problem .',
  'Counterfeit and substandard antimalarial drugs have become a serious problem , which demands reliable analytical tools and implementation of strict regulation of drug quality .',
  "Available data about purities of drugs purchased in cryptomarkets suggest that adulteration is not a severe problem and this agrees with users ' perceptions .",
  'Counterfeit medicines are a serious public health problem in Peru .',
  'Counterfeit drugs are a menacing and deadly problem worldwide .',
  'Counterfeiting has become a serious and underreported problem in the pharmaceutical industry .',
  'Counterfeiting of pharmaceuticals has become a serious problem all over the world , particularly in developing countries .',
  'Chinese liquor is one of the famous distilled spirits and counterfeit liquor is becoming a serious problem in the market .',
  'The production and distribution of counterfeit pharmaceuticals present a serious problem worldwide .'],
 'medicines': ['One problem with such an approach is that the original buyer whose watermark has been found on unauthorized copies can claim that the unauthorized copy was created or caused ( for example , by a security breach ) by the original seller .',
  'Counterfeiting of drugs is a severe public health problem .',
  'Illicit sale of medicines is a serious public health problem in Africa .',
  'Pharmaceutical counterfeiting is becoming a serious problem both in developed and developing countries .',
  'Counterfeit medicines have become a serious global problem .',
  'Pharmaceutical counterfeiting is becoming a serious problem in the world , especially in developing countries including China .',
  'Various types of drugs have been counterfeited , posing a serious public health and safety problem .',
  'Medicines are expensive and hard to access in Yemen , and counterfeit medicines are a serious problem .',
  'This random survey confirms results from previous convenience surveys that counterfeit artesunate is a severe public health problem .',
  'Counterfeit and substandard antimalarial drugs have become a serious problem , which demands reliable analytical tools and implementation of strict regulation of drug quality .',
  "Available data about purities of drugs purchased in cryptomarkets suggest that adulteration is not a severe problem and this agrees with users ' perceptions .",
  'Counterfeit medicines are a serious public health problem in Peru .',
  'Counterfeit drugs are a menacing and deadly problem worldwide .',
  'Counterfeiting has become a serious and underreported problem in the pharmaceutical industry .',
  'Counterfeiting of pharmaceuticals has become a serious problem all over the world , particularly in developing countries .',
  'Chinese liquor is one of the famous distilled spirits and counterfeit liquor is becoming a serious problem in the market .',
  'The production and distribution of counterfeit pharmaceuticals present a serious problem worldwide .'],
 'liquor': ['One problem with such an approach is that the original buyer whose watermark has been found on unauthorized copies can claim that the unauthorized copy was created or caused ( for example , by a security breach ) by the original seller .',
  'Counterfeiting of drugs is a severe public health problem .',
  'Illicit sale of medicines is a serious public health problem in Africa .',
  'Pharmaceutical counterfeiting is becoming a serious problem both in developed and developing countries .',
  'Counterfeit medicines have become a serious global problem .',
  'Pharmaceutical counterfeiting is becoming a serious problem in the world , especially in developing countries including China .',
  'Various types of drugs have been counterfeited , posing a serious public health and safety problem .',
  'Medicines are expensive and hard to access in Yemen , and counterfeit medicines are a serious problem .',
  'This random survey confirms results from previous convenience surveys that counterfeit artesunate is a severe public health problem .',
  'Counterfeit and substandard antimalarial drugs have become a serious problem , which demands reliable analytical tools and implementation of strict regulation of drug quality .',
  "Available data about purities of drugs purchased in cryptomarkets suggest that adulteration is not a severe problem and this agrees with users ' perceptions .",
  'Counterfeit medicines are a serious public health problem in Peru .',
  'Counterfeit drugs are a menacing and deadly problem worldwide .',
  'Counterfeiting has become a serious and underreported problem in the pharmaceutical industry .',
  'Counterfeiting of pharmaceuticals has become a serious problem all over the world , particularly in developing countries .',
  'Chinese liquor is one of the famous distilled spirits and counterfeit liquor is becoming a serious problem in the market .',
  'The production and distribution of counterfeit pharmaceuticals present a serious problem worldwide .'],
 'pharmaceutical': ['One problem with such an approach is that the original buyer whose watermark has been found on unauthorized copies can claim that the unauthorized copy was created or caused ( for example , by a security breach ) by the original seller .',
  'Counterfeiting of drugs is a severe public health problem .',
  'Illicit sale of medicines is a serious public health problem in Africa .',
  'Pharmaceutical counterfeiting is becoming a serious problem both in developed and developing countries .',
  'Counterfeit medicines have become a serious global problem .',
  'Pharmaceutical counterfeiting is becoming a serious problem in the world , especially in developing countries including China .',
  'Various types of drugs have been counterfeited , posing a serious public health and safety problem .',
  'Medicines are expensive and hard to access in Yemen , and counterfeit medicines are a serious problem .',
  'This random survey confirms results from previous convenience surveys that counterfeit artesunate is a severe public health problem .',
  'Counterfeit and substandard antimalarial drugs have become a serious problem , which demands reliable analytical tools and implementation of strict regulation of drug quality .',
  "Available data about purities of drugs purchased in cryptomarkets suggest that adulteration is not a severe problem and this agrees with users ' perceptions .",
  'Counterfeit medicines are a serious public health problem in Peru .',
  'Counterfeit drugs are a menacing and deadly problem worldwide .',
  'Counterfeiting has become a serious and underreported problem in the pharmaceutical industry .',
  'Counterfeiting of pharmaceuticals has become a serious problem all over the world , particularly in developing countries .',
  'Chinese liquor is one of the famous distilled spirits and counterfeit liquor is becoming a serious problem in the market .',
  'The production and distribution of counterfeit pharmaceuticals present a serious problem worldwide .'],
 'triplet': ['The basic problem with lattice energy based methods of crystal structure prediction is that many structures are found within a few kJ mol(-1 ) of the global minimum .',
  'A potential problem with this approach is that real superconductors are described by number-conserving Hamiltonians with long-range interactions , so their topological properties may not be correctly captured by mean-field models that violate number conservation and have short-range interactions .',
  'A major drawback of multipolar electrostatics is the increased computational cost .',
  'For periodic systems , however , the failure to attain the exact homogeneous electron gas limit as well as the semiempirical construction turns out to be a major drawback of the functional .',
  'A major drawback of this procedure is that if N is the number of product vibrational modes , the amount of trajectories necessary to converge the calculations is ∼10(N) × larger than with the standard QCT method .',
  'A current drawback of spintronics is the large power that is usually required for magnetic writing , in contrast with nanoelectronics , which relies on " zero-current , " gate-controlled operations .',
  'Finally , we highlight a severe drawback of tuned range-separated hybrid functionals by discussing the example of the calculation of bond-length alternation in polyacetylene , which leads us to point out the challenges for future developments in this field .',
  'A major drawback of these pulses as theoretical prediction is concerned , however , results from their time-dependent offset : simulations of spin density matrices under the influence of a time-dependent Hamiltonian with non-commuting elements are costly in terms of computational time , rendering data analysis impracticable .',
  'A major drawback of the widely successful density functional theory is its underestimation of the material band gap .',
  'These differences are attributed to a drawback of the DFT technique with respect to the dynamical correlation effects which become very important in complexes with a polar Ru-Cl bond .',
  'In addition , the new method reduces the delocalization error ( many-electron self-interaction error ) which is a severe problem in DFT .',
  "When isotropic exchange coupling is weak , the physical compatibility between both spin Hamiltonian models becomes a serious concern , due to mixing of spin multiplets by local zero-field splitting ( ZFS ) interactions ( ' S-mixing ' ) .",
  'It remains , to this day , a vexing unsolved problem in density-functional theory ( DFT ) .',
  "We perform extensive tests with different classes of functions and levels of data quality , including Monte Carlo data suffering from a severe sign problem and physical data for the Green 's function of the Fröhlich polaron .",
  'A detailed analysis of a severe intruder state problem in the multistate multireference perturbation theory ( MS-MRPT ) calculations on the ground state of manganese dimer is presented .',
  'It will cause a severe problem in controllable and reproducible spin manipulations , not to mention the clarification of the spin-dependent transport mechanism .',
  'The failure of the time-dependent density-functional theory to describe long-range charge-transfer ( CT ) excitations correctly is a serious problem for calculations of electronic transitions in large systems , especially if they are composed of several weakly interacting units .',
  'The unknown amount of hydrodynamically coupled liquid is a serious problem in the interpretation of QCM experiments .',
  'The degree of electronic and nuclear coupling in the Cl + H2 reaction has become a vexing problem in chemical dynamics .',
  'From different initial conformations , helical conformations were reached and the multiple energy minima did not become a serious problem .',
  'In this manner , it is possible to synthesize Ising interaction ( 2IzSz ) Hamiltonians in homonuclear spin networks and thereby avoid dipolar truncation -- a serious problem essentially all previous homonuclear dipolar recoupling experiments suffer from .',
  'The incomplete cancellation of the electron self-interaction can be a serious shortcoming of density-functional theory especially when treating odd-electron systems .',
  'Frustrated antiferromagnets are important materials whose quantum Monte Carlo simulation suffers from a severe sign problem .',
  'Lattice QCD at finite density suffers from a severe sign problem , which has so far prohibited simulations of the cold and dense regime .',
  'However , overcoordination of the ion pair at all distances remains as a serious shortcoming of the current classical models .',
  'Two main conclusions concerning triplet-triplet transitions are drawn in this study : First , the very good agreement between unrestricted and restricted DFT results indicates that spin contamination of the triplet state is not a serious problem when computing triplet-triplet spectra of common organic molecules .'],
 'hbv': ['One problem with the development of an HBV vaccine is that some vaccinees and patients do not respond to HBsAg directly ; our results indicate that this problem can be circumvented using the response to HBcAg .',
  "Viral hepatitis B is a serious health problem , above all in the world 's developing countries .",
  'Hepatitis B virus ( HBV ) infection , a cause of hepatocellular carcinoma ( HCC ) , remains a serious global health concern .',
  'Hepatitis B Virus ( HBV ) is a causative agent of both acute and chronic hepatitis , a major etiologic factor of primary hepatocellular carcinoma , and a serious global health problem , with over 240 million estimated chronically infected individuals .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious clinical problem because of its worldwide distribution and potential adverse sequelae .',
  'Hepatitis B virus ( HBV ) infection affects 364 million people worldwide and causes a serious global public health problem .',
  'Chemotherapy-induced hepatitis B virus ( HBV ) reactivation is a serious problem in chronic HBV carriers with hematologic malignancies .',
  'Hepatitis B , a serious infectious disease caused by the hepatitis B virus ( HBV ) , remains a worldwide social and public health problem .',
  'Despite that some approved drugs and genetically engineered vaccines against hepatitis B virus ( HBV ) are available for HBV patients , HBV infection is still a severe public health problem in the world .',
  'Hepatitis B virus ( HBV ) infection is a serious health problem not only in Egypt , but also worldwide .',
  'Drug-resistant hepatitis B virus ( HBV ) is a serious problem affecting antiviral therapy .',
  'Chronic hepatitis B is a serious health problem .',
  'Currently , chronic hepatitis B virus ( HBV ) infection remains a serious public health problem in the world .',
  'Hepatitis B , an infectious disease caused by hepatitis B virus ( HBV ) , is still a serious problem affecting global public health .',
  'Our study clearly indicates a high prevalence of those viruses , particularly of enterically transmitted HAV and HEV in Bangladesh , which appeared to be a serious health problem in this developing country .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem worldwide .',
  'Chronic hepatitis b ( CHB ) is a serious problem worldwide .',
  'Hepatitis B virus(HBV)reactivation is a serious clinical problem for HBV infected patients , and one of its possible causes is chemotherapy for malignant disease .',
  'Hepatitis B infection is a serious health problem throughout the world .',
  'Hepatitis B has long been a serious public health problem both in Greece and in Albania .',
  'Background Hepatitis B virus ( HBV ) infection is a serious health problem in Pakistan .',
  'Hepatitis B virus ( HBV ) is a serious public health problem in need of better treatment options , and aspects of its life cycle make it an excellent target for RNAi-based therapeutics .',
  'Hepatitis B virus ( HBV ) infection remains a serious public health problem worldwide .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem worldwide .',
  'Hepatitis B is a serious public health problem .',
  'Hepatitis B virus ( HBV ) infection remains a serious global health problem despite the availability of a highly effective vaccine .',
  'Hepatitis B virus ( HBV ) is a highly contagious pathogen that has become a severe public health problem and a major cause of morbidity and mortality , particularly in developing countries .',
  'Hepatitis B virus ( HBV ) infection constitutes a serious global health problem .',
  'Hepatitis B virus ( HBV ) infection represents a serious global health problem and persistent HBV infection is associated with an increased risk of cirrhosis , hepatocellular carcinoma and liver failure .',
  'Hepatitis B virus ( HBV ) infection is a serious health problem worldwide , and the current treatment methods including vaccines , immunomodulators , interferons and nucleoside analogs are far from satisfactory .',
  'Taiwan is an area with a high prevalence of HBV where hepatitis B flare-up has become a serious problem of HBV carriers who must rely on chemotherapy to treat their diseases .',
  'Hepatitis B is a serious global public health concern .',
  'Viral hepatitis is a serious public health problem with hepatitis B virus ( HBV ) being one of its principle causes affecting billions of people globally .',
  'Chronic infection with hepatitis B virus ( HBV ) is a serious global health problem .',
  'Chronic hepatitis B virus ( HBV ) infection can cause cirrhosis and hepatocellular carcinoma and is therefore a serious public health problem .',
  'Hepatitis B virus infection is a serious health problem worldwide .',
  'Without hygiene education and HBV/HCV prevention , viral hepatitis infection will become a serious public health problem in Burkina Faso .',
  'These data showed that Hb S is a serious public health problem in Mauritania .',
  'Hepatitis B virus infection poses a serious health problem in Taiwan , and plays an important role in the development of chronic hepatitis , liver cirrhosis and hepatoma ; the latter two are among the 10 leading causes of death in Taiwan .',
  'HBV infection poses a serious problem in patients with ALL .',
  'Hepatitis B Virus ( HBV ) infection is a serious health problem among Asian Americans .',
  'Chronic hepatitis B virus ( HBV ) infection affects approximately 240 million people worldwide and remains a serious public health concern because its complete cure is impossible with current treatments .',
  'This result may be related to the lower socioeconomical status of Sanliurfa ( which is located in Southeast Anatolia ) , and indicates that HBV should be considered as a serious public health problem in East and Southeast parts of Turkey .',
  'Hepatitis B has long been a serious public health problem in Greece .',
  'HBsAg antigenemia still constitutes a serious clinical problem .',
  "In conclusion , reverse seroconversion of HBV is not a rare complication of autologous HSCT , and the risk of reverse seroconversion after treatment is a serious concern due to possible complications arising from patients ' suppressed immune systems .",
  'Recently , HBV-related acute on chronic liver failure ( HBV-ACLF ) has emerged as a serious and emergent medical problem in Bangladesh .',
  'Hepatitis B is a serious public health problem all around the world .',
  'Hepatitis B viruses ( HBVs ) represent a serious public health problem affecting 350 to 400 million HBV carriers worldwide .',
  'This is a serious public health concern and a challenge for a country with high prevalence of hepatitis B infection .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious public health problem and may progress to liver fibrosis , cirrhosis and hepatocellular carcinoma .',
  'Hepatitis B virus remains a serious problem , particularly for patients with end-stage renal disease on maintenance hemodialysis .',
  'HBV reactivation and severe liver disease during cytotoxic treatment may become a serious and common problem in this region as cytotoxic chemotherapy is more widely used .',
  'While an effective vaccine against hepatitis B virus ( HBV ) has long been available , chronic HBV infection remains a severe global public health concern .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem leading to cirrhosis and hepatocellular carcinoma .',
  'Hepatitis B ( HB ) is a serious global public health problem that put health professionals particularly at risk .',
  'Hepatitis B virus ( HBV ) infection remains a serious public health problem , due in part to low vaccination rates among high-risk adults , many of whom decline vaccination because of barriers such as perceived inconvenience or discomfort .',
  'Hepatitis B is a serious public health problem .',
  'At Sahlgren Hospital , Göteborg , hepatitis B has been a serious problem for several years among the personnel in the hemodialysis and renal transplantation wards as well as in the chemical laboratories .',
  'Chronic hepatitis B is a serious long-term problem for children surviving malignancy .',
  'Hepatitis B virus ( HBV ) reactivation in immunosuppressed cancer patients is a serious clinical problem for HBV carriers undergoing chemotherapy , because it may result in severe liver injury and prevent completion of life-saving treatment of the underlying malignant disease .',
  'Hepatitis B outbreaks in health-care settings are still a serious public health concern worldwide .',
  'Chronic hepatitis B virus infection is a serious problem because of its worldwide distribution and possible adverse chronic sequelae , such as cirrhosis and hepatocellular carcinoma .',
  'Hepatitis B virus ( HBV ) infections are a severe health concern worldwide .',
  'Chronic hepatitis B is a serious global health problem .',
  'Chronic infection by HBV is a serious health concern .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem worldwide .',
  'Although widespread immunization , improved blood supply testing , and emphasis on safe sex have significantly decreased new HBV infections , the large reservoir of infected individuals ( 400 million ) remains a serious health problem .',
  'Hepatitis B infection remains a serious public health problem in northwest China .',
  "As one of the world 's most common infectious diseases , hepatitis B virus ( HBV ) is a serious worldwide public health problem , with HBV-associated liver disease accounting for more than half a million deaths each year .",
  'Chronic hepatitis B is a serious and chronic health problem , requiring self-management to control the disease and related complications .',
  'Hepatitis B virus infection is a serious global health problem and causes life-threatening liver disease .',
  'Chronic hepatitis B virus ( HBV ) infection remains a serious global health problem , inducing a spectrum of diseases , including asymptomatic HBV carriage ( ASC ) and chronic hepatitis B ( CHB ) .',
  'Hepatitis B virus ( HBV ) infection is a serious global health problem .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious clinical problem because of its worldwide distribution and possible adverse sequelae .',
  'Hepatitis B virus ( HBV ) is a serious global health problem , and HBV genotype is an important determinant of disease progression and treatment outcome .',
  'Chronic hepatitis B virus ( HBV ) infection causes liver cirrhosis and hepatocellular carcinoma and remains a serious health problem worldwide .',
  'Prevalence of hepatitis delta virus ( HDV ) infection in chronic hepatitis B patients in eastern Turkey : still a serious problem to consider .',
  'Hepatitis B infection is a serious global public health problem .',
  'Reactivation of hepatitis B virus ( HBV ) after cytotoxic chemotherapy is a serious problem , and it occurred to 41 % of breast cancer patients carrying HBV .',
  'Though the global epidemiology of hepatitis B virus infection has declined due to effective immunization , chronic hepatitis B ( CHB ) remains a serious public health problem and there is still a need for more treatment options that are efficient , safe and simple for different kinds of CHB patients .',
  'Therefore , HTLV-1 infection is a serious public health concern .',
  'Hepatitis B virus ( HBV ) infection remains to be a serious public health problem in China .',
  'Hepatitis B is a serious epidemiological problem in uremic patients treated with renal replacement therapy .',
  'Chronic hepatitis B ( CHB ) remains a serious clinical problem worldwide .',
  'Human hepatitis B virus ( HBV ) infection remains a serious health problem worldwide .',
  'Hepatitis B virus ( HBV ) flare is a serious problem following hematopoietic stem cell transplantation ( HSCT ) , and the mortality rate is high if severe hepatitis occurs .',
  'Hepatitis A and B are still a serious global public health problem .',
  'In these areas , the HBV prevalence is still high which makes this virus a serious public health concern to the entire region .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious problem due to its extensive worldwide distribution and poor prognosis including cirrhosis and/or hepatocellular carcinoma .',
  'Hepatitis B virus ( HBV ) infection is a serious global health problem .',
  'Hepatitis B virus ( HBV ) continues to be a serious worldwide health problem despite the use of protective HBV vaccines and therapeutic regimens against chronic HBV infection .',
  'Hepatitis B constitutes a serious public health problem .',
  'This article is relevant in that it outlines the significant achievements of a dedicated group of individuals to solve a serious public health problem , that of eliminating hepatitis B as a risk for our children .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem in sub-Saharan Africa .',
  'Emergence of lamivudine-resistant variants , with amino acid substitutions in the Tyr-Met-Asp-Asp ( YMDD ) motif of hepatitis B virus ( HBV ) reverse transcriptase , is a serious problem in antiviral therapy .',
  'Chronic hepatitis B virus ( HBV ) infection due to perinatal mother-to-infant transmission ( MTIT ) remains a serious global health problem .',
  'Hepatitis B virus ( HBV ) infection is still a serious worldwide problem , and vaccination is the most effective strategy for primary prevention of the infection .',
  'The emergence of drug-resistant mutants of hepatitis B virus ( HBV ) is a serious problem during antiviral therapy of patients with chronic hepatitis B. Lamivudine-resistant mutants with a mutation in the YMDD motif of reverse transcriptase of HBV emerge in approximately one half of the treated patients within 5 years .',
  'Hepatitis B is a dreadful infectious disease and a major global health problem .',
  'Despite effective vaccination programs in many countries , HBV infection is still a serious health problem throughout the world ; more than 2 billion people have been infected with Hepatitis B virus ( HBV ) .',
  'HBV and HDV infection is still a serious health problem in Southeastern Turkey .',
  'Chronic hepatitis B virus ( HBV ) infection poses a serious public health problem in many parts of the world .',
  'Human immunovirus infection among pregnant women continues to be a serious public health concern .',
  'Hepatitis B infection is a serious health problem in endemic areas particularly among immunocompromised patients .',
  'Hepatitis B represents a serious public health problem in all parts of the world , and particularly in hyperendemic areas , where the majority of infections occur in childhood .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem in many parts of the world .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem worldwide .',
  'Hepatitis B virus ( HBV ) remains a serious worldwide health problem and the possibility to control it will depend on the availability of safe , effective and affordable vaccines .',
  'Chronic HBV infection in kidney , heart , and other organs has become a serious long-term problem and one of the most frequent and important comorbidities affecting graft and patient survival .',
  'Hepatitis B remains a serious public health problem .',
  'HBV infection is a serious global health problem , with 2 billion people infected worldwide , and 350 million suffering from chronic HBV infection .',
  'Hepatitis B virus ( HBV ) infection and its sequelae such as cirrhosis and hepatocellular carcinoma has remained a serious public health problem throughout the world .',
  'The results show that HBV infection is a serious problem among the children of mountain aborigines in Hualien , with nearly one-third of them carrying HBsAg .',
  'Chronic hepatitis B ( CHB ) infection is a serious public health problem due to its potential liver disease sequelae and highly expensive medical costs such as the need for liver transplantation .',
  'Hepatitis B induced by HBV is a serious health problem .',
  'Chronic hepatitis B is a serious public health concern .',
  'Hepatitis B virus ( HBV ) reactivation is a serious clinical problem in HBV carriers undergoing chemotherapy .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem in sub-Saharan Africa pregnant women .',
  'HB is a serious global public health problem and the health professionals are most at risk .',
  'Hepatitis B virus infection is a serious public health problem .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious problem because of its world wide distribution and possible adverse chronic sequalae such as cirrhosis and hepatocellular carcinoma .',
  'Hepatitis B virus ( HBV ) infection is a serious global health problem that is associated with huge social and economic costs .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious public health problem because of its worldwide prevalence and potential to cause adverse consequences .',
  'Hepatitis B ( HB ) is a serious public health problem in China .',
  'Persistent BHHV among nurses is a serious concern .',
  'Hepatitis B virus ( HBV ) infection causing acute and chronic hepatitis is a serious problem worldwide , whereas the current treatment methods are unsatisfactory .',
  'Hepatitis B virus ( HBV ) infection is a severe health problem in the world ; however , there is still no satisfactory therapeutic strategy for the HBV infection .',
  'Hepatitis B virus ( HBV ) infection is a severe health problem all over the world .',
  'Hepatitis B virus ( HBV ) is a serious global health problem .',
  'Hepatitis B virus ( HBV ) remains a serious public health problem worldwide , accounting for high morbidity and mortality rates as well as significant personal , societal , and economic costs .',
  'Despite the introduction of universal vaccination against hepatitis B in over 100 countries , persistent HBV infection is still a serious problem worldwide , causing an estimated annual death rate of one million .',
  'HBV infection is a serious public health problem worldwide , which can contribute to the incidence of chronic hepatitis B ( CHB ) , cirrhosis , and hepatocellular carcinoma ( HCC ) .',
  'Hepatitis B virus ( HBV ) infection constitutes a serious global health problem .',
  'Hepatitis B virus infection is a serious health problem worldwide , and more than 350 million people are chronic carriers , constituting a major global threat .',
  'Hepatitis B virus ( HBV ) infection remains a severe clinical concern in China .',
  'Infection with Hepatitis B virus ( HBV ) is a serious public health problem worldwide , with over 360 million carriers .',
  'This is a serious public health problem and challenge for a country with high prevalence of hepatitis B infection .',
  'Hepatitis B virus ( HBV ) infection is a serious , world-wide problem .',
  'Severe haemorrhagic thrombocytopenia in infectious mononucleosis with positive Epstein-Barr virus ( EBV ) serology remains a threatening clinical problem .',
  'Hepatitis B virus ( HBV ) infection is one of the most prevalent viral infections in humans and represents a serious public health problem .',
  'Chronic hepatitis B ( CHB ) is a serious public health problem , and Traditional Chinese Medicine ( TCM ) plays an important role in the control and treatment for CHB .',
  'Hepatitis-B infection is not commonly perceived as a serious medical problem in Nigeria .',
  'Hepatitis B virus ( HBV ) infection is a serious clinical problem affecting approximately 2 billion people worldwide .',
  'Hepatitis B virus ( HBV ) infection is a severe health problem , especially in developing countries .',
  'There are more than 100 million asymptomatic HBV carriers ( ASCs ) in China and they are at a high risk of developing liver disease , which creates a serious health problem .',
  'Hepatitis B virus ( HBV ) infection remains a severe public health problem .',
  'Hepatitis B virus ( HBV ) infection is known as a serious problem in the domain of public health and approximately 350 million people across the world are affected with this infectious disease .',
  'Hepatitis B is a serious public health problem leading to chronic infection , liver cirrhosis , and hepatocellular carcinoma .',
  'Chronic hepatitis B is one of the most frequent infectious disease in the world and represents a serious problem of public health',
  'Chronic hepatitis B virus ( HBV ) infection , a serious public health problem leading to cirrhosis and hepatocellular carcinoma , is currently treated with either pegylated alpha interferon ( pegIFN-α ) or one of the five nucleos(t)ide analogue viral DNA polymerase inhibitors .',
  'These results indicate that hepatitis B is a serious problem of public health in our country that merit to take immediate prophylactic measures .',
  'HB is still a serious health problem in economically compromised parts of the world .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem worldwide .',
  'Hepatitis B virus ( HBV ) infection is a serious global health problem .',
  'Hepatitis B virus ( HBV ) infection is a serious global health problem .',
  'Chronic hepatitis B continues to be a serious problem worldwide .',
  'Hepatitis B virus ( HBV ) infection is a major risk for hepatocellular carcinoma ( HCC ) , and it is a serious global health problem with two billion people exposed to it worldwide .',
  'Chronic hepatitis B ( CHB ) is a serious health problem in Korea .',
  'Hepatitis B virus ( HBV ) infection is a serious global public health problem .',
  'However , for patients who have genetic diseases which predispose them to the development of hemophagocytic lymphohistiocytosis ( HLH ) , EBV infection is a life-threatening problem .',
  'Hepatitis B virus ( HBV ) infections are a serious health problem in the United States , where approximately 18,000 cases are reported each year to the Centers for Disease Control .',
  'Hepatitis B is a serious global health problem .',
  'Chronic hepatitis B ( CHB ) infection is a serious and prevalent health concern worldwide , and the development of effective drugs and strategies to combat this disease is urgently needed .',
  'HBV infection is a serious global heath problem .',
  'Hepatitis B is a severe public health problem .',
  'Hepatitis B ( HB ) is a serious global public health problem .',
  'Hepatitis B is a serious public health problem in China .',
  'Vietnamese males have the highest incidence of liver cancer of any ethnic group , and HBV infection is a serious and prevalent health problem among Vietnamese immigrants .',
  'Hepatitis B is a serious public health problem across sub-Saharan Africa .',
  'Hepatitis B , a disease entity currently affecting more than 350 million persons worldwide , is also a serious health problem in Taiwan .',
  'Viral hepatitis is a serious global public health problem affecting billions of people globally , and both hepatitis B virus ( HBV ) and hepatitis C virus ( HCV ) infections are rapidly spreading in the developing countries including Bangladesh due to the lack of health education , poverty , illiteracy and lack of hepatitis B vaccination .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious problem owing to its worldwide distribution and potential adverse sequelae that include cirrhosis and/or hepatocellular carcinoma .',
  'Chronic hepatitis B ( CHB ) virus ( HBV ) infection remains a severe problem worldwide .',
  'Chronic hepatitis B is a serious health problem worldwide .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious clinical problem because of its world-wide distribution and potential adverse sequelae .',
  'Hepatitis B is a serious public health problem throughout the world .',
  'Hepatitis B virus ( HBV ) reactivation from resolved infection is a serious problem which can frequently lead to severe hepatitis .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem , which can be transmitted through various routes ( e.g. , blood donation ) and cause hepatitis , liver cirrhosis and liver cancer .',
  'Perinatal transmission of hepatitis B virus continues to be a serious global public health concern .',
  'Hepatitis B virus ( HBV ) , a serious infectious and widespread human pathogen , represents a major health problem worldwide .',
  'These results demonstrate the high and increasing rate of HTLV-III infection among groups at risk for AIDS , and suggest that HTLV-III-related diseases will be a serious problem in the years ahead .',
  'Although a majority of countries in the Middle East show intermediate or high endemicity of hepatitis B virus ( HBV ) infection , which clearly poses a serious public health problem in the region , the situation in the Republic of Syria remains unclear .',
  'Hepatitis B virus ( HBV ) infection is a serious health problem in the developing countries including Pakistan .',
  'Chronic hepatitis B virus ( HBV ) infection remains a serious global health concern .',
  'Hepatitis B virus ( HBV ) infection is a serious global public health problem affecting billions of people globally .',
  'The burden of hepatitis B virus ( HBV ) infection is a serious public health problem all over the world .',
  'Hepatitis B virus ( HBV ) infection is still a serious public health problem .',
  'HBV infection is a serious public health problem among adult population in Henan .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious problem because of its worldwide distribution and possible adverse sequelae , such as cirrhosis and hepatocellular carcinoma .',
  'Hepatitis B virus ( HBV ) infection is a serious clinical problem worldwide .',
  'Recurrence of Hepatitis B Virus infection in patients undergoing liver transplanted ( LT ) is a serious and often fatal problem .',
  'Hepatitis B virus ( HBV ) infection is a serious health problem worldwide .',
  'hepatitis B virus ( HBV ) reactivation in immunocompromised states is a well-known event that may be a serious problem in endemic areas of infection .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem in China and worldwide .',
  'Chronic hepatitis B virus ( HBV ) infection represents a serious global health problem and resistance to lamivudine ( LAM ) has become a serious clinical challenge .',
  'Hepatitis B virus ( HBV ) infection remains a serious public health concern worldwide .',
  'Hepatitis B virus infection is a serious problem globally , and particularly in the Western Pacific Region where the population suffers disproportionately from the infection and its sequelae .',
  'Despite an effective vaccine , HBV poses a serious health problem globally , accounting for 257 million chronic carriers .',
  'Hepatitis B virus ( HBV ) infection is a serious global health problem , with 2 billion people infected worldwide , and 350 million suffering from chronic HBV infection .'],
 'hepatitis': ['One problem with the development of an HBV vaccine is that some vaccinees and patients do not respond to HBsAg directly ; our results indicate that this problem can be circumvented using the response to HBcAg .',
  'Type 1 interferons ( IFNs ) have been shown to be efficacious against hepatitis C virus ( HCV ) , hepatitis B virus ( HBV ) , and some cancers with a significant drawback of short drug exposure .',
  "Viral hepatitis B is a serious health problem , above all in the world 's developing countries .",
  'Hepatitis is a serious health concern with a high rate of mortality and morbidity world over .',
  'Hepatitis B virus ( HBV ) infection , a cause of hepatocellular carcinoma ( HCC ) , remains a serious global health concern .',
  'Hepatitis B Virus ( HBV ) is a causative agent of both acute and chronic hepatitis , a major etiologic factor of primary hepatocellular carcinoma , and a serious global health problem , with over 240 million estimated chronically infected individuals .',
  'Hepatitis C virus ( HCV ) is a serious global problem , and present therapeutics are inadequate to cure HCV infection .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious clinical problem because of its worldwide distribution and potential adverse sequelae .',
  'Chronic hepatitis C virus infection represents a serious global public health problem , typically resulting in fibrosis , cirrhosis , and ultimately hepatocellular carcinoma .',
  'Hepatitis B virus ( HBV ) infection affects 364 million people worldwide and causes a serious global public health problem .',
  'Chemotherapy-induced hepatitis B virus ( HBV ) reactivation is a serious problem in chronic HBV carriers with hematologic malignancies .',
  'Recurrent hepatocellular carcinoma after living donor liver transplantation : a preventable problem or an acceptable risk ?',
  'Hepatitis B , a serious infectious disease caused by the hepatitis B virus ( HBV ) , remains a worldwide social and public health problem .',
  'Hepatitis C virus ( HCV ) infection remains a serious health problem worldwide .',
  'US participants reported higher levels of knowledge of IPV , were more likely to believe that IPV was a serious problem , and were more likely to consider IPV to be a healthcare problem compared with Vietnamese and Chinese participants .',
  'Despite that some approved drugs and genetically engineered vaccines against hepatitis B virus ( HBV ) are available for HBV patients , HBV infection is still a severe public health problem in the world .',
  'Hepatitis B virus ( HBV ) infection is a serious health problem not only in Egypt , but also worldwide .',
  'HCV infected patients and healthy subjects were selected from the expatriate Egyptian population living in Qatar , where chronic HCV infection poses a serious health problem .',
  'Drug-resistant hepatitis B virus ( HBV ) is a serious problem affecting antiviral therapy .',
  'Chronic hepatitis B is a serious health problem .',
  'Currently , chronic hepatitis B virus ( HBV ) infection remains a serious public health problem in the world .',
  'Hepatitis B , an infectious disease caused by hepatitis B virus ( HBV ) , is still a serious problem affecting global public health .',
  'Abstract Hepatitis C virus ( HCV ) infection is a serious health problem worldwide that can lead to hepatocellular carcinoma or end-stage liver disease .',
  'Interferon (IFN)-alpha is regarded as an efficient therapy for chronic hepatitis C , despite the fact that less than 50 % of patients receiving IFN-alpha are known to show an initial biochemical response , and several adverse reactions related to this therapy are becoming a serious clinical problem .',
  'Our study clearly indicates a high prevalence of those viruses , particularly of enterically transmitted HAV and HEV in Bangladesh , which appeared to be a serious health problem in this developing country .',
  'Graft loss because of hepatitis C virus recurrence is a serious problem after liver transplantation ( LT ) , and the response to pegylated interferon ( PEG-IFN ) and ribavirin ( RBV ) is poor .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem worldwide .',
  'Chronic hepatitis b ( CHB ) is a serious problem worldwide .',
  'Currently , hepatitis C virus ( HCV ) infection is considered a serious health-care problem all over the world .',
  'Hepatitis B virus(HBV)reactivation is a serious clinical problem for HBV infected patients , and one of its possible causes is chemotherapy for malignant disease .',
  'Hepatitis C virus ( HCV ) infection is a serious public health problem , since 80 % to 85 % of HCV carriers develop a persistent infection that can progress into liver cirrhosis and hepatocarcinoma .',
  'Hepatitis B infection is a serious health problem throughout the world .',
  'Hepatitis C represents a serious worldwide health-care problem .',
  'Hepatitis B has long been a serious public health problem both in Greece and in Albania .',
  'Background Hepatitis B virus ( HBV ) infection is a serious health problem in Pakistan .',
  'Hepatitis B virus ( HBV ) is a serious public health problem in need of better treatment options , and aspects of its life cycle make it an excellent target for RNAi-based therapeutics .',
  'Viral hepatitis is a serious health problem throughout the world .',
  'Hepatitis B virus ( HBV ) infection remains a serious public health problem worldwide .',
  'Care-associated HCV infections represented a huge part of hepatitis C burden in the past via contaminated blood and unsafe injections and continue to be a serious problem of public health .',
  'The determination of the bioequivalence of HVDs has been a vexing problem since the inception of the current regulations .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem worldwide .',
  'Hepatitis B is a serious public health problem .',
  'While a test for multiple antibodies is thought to be effective for the screening of HCV , more blood needs to be discarded , having a serious cost-performance problem .',
  'Hepatitis B virus ( HBV ) infection remains a serious global health problem despite the availability of a highly effective vaccine .',
  'Hepatitis B virus ( HBV ) is a highly contagious pathogen that has become a severe public health problem and a major cause of morbidity and mortality , particularly in developing countries .',
  'Hepatitis B virus ( HBV ) infection constitutes a serious global health problem .',
  'Hepatitis B virus ( HBV ) infection represents a serious global health problem and persistent HBV infection is associated with an increased risk of cirrhosis , hepatocellular carcinoma and liver failure .',
  'Mouse hepatitis virus ( MHV ) infection in laboratory mouse populations is a serious problem , because the MHV infections are known to interfere with research results .',
  'Hepatitis B virus ( HBV ) infection is a serious health problem worldwide , and the current treatment methods including vaccines , immunomodulators , interferons and nucleoside analogs are far from satisfactory .',
  'Hepatitis C virus ( HCV ) infection represents a serious health-care problem .',
  'Taiwan is an area with a high prevalence of HBV where hepatitis B flare-up has become a serious problem of HBV carriers who must rely on chemotherapy to treat their diseases .',
  'Hepatitis B is a serious global public health concern .',
  'Especially the chronic form of hepatitis C ( HC ) , with 55 - 85 % of acute cases progressing to it , is a serious problem worldwide .',
  'Viral hepatitis is a serious public health problem with hepatitis B virus ( HBV ) being one of its principle causes affecting billions of people globally .',
  'Chronic infection with hepatitis B virus ( HBV ) is a serious global health problem .',
  'Viral hepatitis B , C and delta still remain a serious problem worldwide .',
  'However , a small proportion of patients persistently infected with HCV , in whom anti-HCV are undetectable , constitute a serious diagnostic and possibly epidemiologic problem , as they could facilitate pathogen spread in the population .',
  'The chronic infection by the hepatits C virus represents a serious sanitary problem affecting 1 - 3 % of the world-wide population .',
  'Viral hepatitis , mainly hepatitis B and C , is a serious public health problem worldwide .',
  'Graft loss due to hepatitis C ( HCV ) recurrence is a serious problem after LT .',
  'Hepatitis C virus ( HCV ) recurrence after orthotopic liver transplantation ( OLT ) remains a serious problem in the clinical management of post-oLT patients .',
  'Worldwide , viral hepatitis chronic infections are a serious health problem and a very interesting topic for both clinicians and researchers .',
  'Chronic hepatitis B virus ( HBV ) infection can cause cirrhosis and hepatocellular carcinoma and is therefore a serious public health problem .',
  'Hepatitis C virus infection among maintenance hemodialysis patients : a preventable problem of the world .',
  'Hepatitis C virus ( HCV ) infection is a serious problem among those co-infected with human immunodeficiency virus ; however , its impact in the central nervous system ( CNS ) remains unclear .',
  'Hepatitis E virus ( HEV ) infection is a serious public health concern in developing countries .',
  'Hepatitis B virus infection is a serious health problem worldwide .',
  'Without hygiene education and HBV/HCV prevention , viral hepatitis infection will become a serious public health problem in Burkina Faso .',
  'We conclude that HCV infection is a serious health problem among kidney transplant recipients and it significantly affects the graft outcome .',
  '[ Viral hepatitis ... a serious public health problem ] .',
  'These data showed that Hb S is a serious public health problem in Mauritania .',
  'HCV is a serious public health concern , and if IDU are to be encouraged into drug treatment it is essential that service providers are perceived to be non-discriminatory .',
  'Hepatitis B virus infection poses a serious health problem in Taiwan , and plays an important role in the development of chronic hepatitis , liver cirrhosis and hepatoma ; the latter two are among the 10 leading causes of death in Taiwan .',
  'HBV infection poses a serious problem in patients with ALL .',
  'Hepatitis C virus ( HCV ) genotype 3a infection poses a serious health problem worldwide .',
  'Hepatitis C virus infection constitutes a serious health problem in need of more effective therapies .',
  'The viral hepatitis is a serious public health problem worldwide .',
  'Hepatitis C virus ( HCV ) infection has become a severe health problem worldwide .',
  'Hepatitis C virus ( HCV ) infection represents a serious health problem .',
  'Hepatitis B Virus ( HBV ) infection is a serious health problem among Asian Americans .',
  'Chronic hepatitis B virus ( HBV ) infection affects approximately 240 million people worldwide and remains a serious public health concern because its complete cure is impossible with current treatments .',
  'This result may be related to the lower socioeconomical status of Sanliurfa ( which is located in Southeast Anatolia ) , and indicates that HBV should be considered as a serious public health problem in East and Southeast parts of Turkey .',
  'Hepatitis B has long been a serious public health problem in Greece .',
  'Hepatitis E virus ( HEV ) infection is a serious health problem in developing countries and is also increasingly reported in industrialized regions .',
  'HBsAg antigenemia still constitutes a serious clinical problem .',
  "In conclusion , reverse seroconversion of HBV is not a rare complication of autologous HSCT , and the risk of reverse seroconversion after treatment is a serious concern due to possible complications arising from patients ' suppressed immune systems .",
  'Hepatitis C virus ( HCV ) is a serious global health problem affecting approximately 130 - 150 million individuals .',
  'On account of the asymptomatic course , no possibility to prevent by vaccination and \n the serious consequences of long-term infection ( liver cirrhosis , hepatocellular carcinoma ) , hepatitis C ( HCV \n infection ) is a serious public health problem .',
  'Recently , HBV-related acute on chronic liver failure ( HBV-ACLF ) has emerged as a serious and emergent medical problem in Bangladesh .',
  'Hepatitis B is a serious public health problem all around the world .',
  'Hepatitis B viruses ( HBVs ) represent a serious public health problem affecting 350 to 400 million HBV carriers worldwide .',
  'This is a serious public health concern and a challenge for a country with high prevalence of hepatitis B infection .',
  'Hepatitis C virus ( HCV ) infection is a serious and rising global healthcare problem .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious public health problem and may progress to liver fibrosis , cirrhosis and hepatocellular carcinoma .',
  'Hepatitis C virus ( HCV ) infection is a serious health problem in New York City .',
  'Hepatitis B virus remains a serious problem , particularly for patients with end-stage renal disease on maintenance hemodialysis .',
  'Hepatitis C virus ( HCV ) infection is a serious problem worldwide .',
  'HBV reactivation and severe liver disease during cytotoxic treatment may become a serious and common problem in this region as cytotoxic chemotherapy is more widely used .',
  'While an effective vaccine against hepatitis B virus ( HBV ) has long been available , chronic HBV infection remains a severe global public health concern .',
  'The detection of HCC in cirrhotic patients with BEV remains a serious , unsolved problem .',
  'Viral hepatitis C is a serious public health problem in France by the number of infected patients , the evolutive profile and by the lack of fully efficient therapeutics .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem leading to cirrhosis and hepatocellular carcinoma .',
  'Hepatitis C is emerging as a serious worldwide problem .',
  'Hepatitis B ( HB ) is a serious global public health problem that put health professionals particularly at risk .',
  'Hepatitis B virus ( HBV ) infection remains a serious public health problem , due in part to low vaccination rates among high-risk adults , many of whom decline vaccination because of barriers such as perceived inconvenience or discomfort .',
  'Although viral hepatitis infections are recognized as a serious health problem in the country , not many epidemiological and clinical studies have been done .',
  'Hepatitis is a serious public health problem with increasing cases and property damage in Heng County .',
  'Hepatitis C virus ( HCV ) infection is a serious problem worldwide , but no effective drugs are currently available .',
  'Hepatitis C virus ( HCV ) infection is a serious public health concern throughout the world .',
  'Hepatitis B is a serious public health problem .',
  'The hepatitis E virus causes acute viral hepatitis endemic in much of the developing world and is a serious public health problem .',
  'At Sahlgren Hospital , Göteborg , hepatitis B has been a serious problem for several years among the personnel in the hemodialysis and renal transplantation wards as well as in the chemical laboratories .',
  'Chronic hepatitis B is a serious long-term problem for children surviving malignancy .',
  'Hepatitis B virus ( HBV ) reactivation in immunosuppressed cancer patients is a serious clinical problem for HBV carriers undergoing chemotherapy , because it may result in severe liver injury and prevent completion of life-saving treatment of the underlying malignant disease .',
  'Hepatitis C is a serious public health problem with more than 170 million chronic carriers worldwide .',
  'Hepatitis B outbreaks in health-care settings are still a serious public health concern worldwide .',
  'Although more than 80 per cent of the study group had heard of hepatitis C , only 50 per cent considered the infection to be a serious problem .',
  'Chronic hepatitis B virus infection is a serious problem because of its worldwide distribution and possible adverse chronic sequelae , such as cirrhosis and hepatocellular carcinoma .',
  'Hepatitis C virus ( HCV ) infection one of the most common blood-borne infections is endemic in Cameroon and a serious problem in hemodialysis ( HD ) .',
  'Hepatitis B virus ( HBV ) infections are a severe health concern worldwide .',
  'Viral hepatitis is a serious global public health problem .',
  'Chronic hepatitis B is a serious global health problem .',
  'Chronic infection by HBV is a serious health concern .',
  'Infection with hepatitis C virus ( HCV ) is a serious public health problem worldwide .',
  'Hepatitis caused by HEV infection has been a serious public health problem in developing countries .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem worldwide .',
  'Although widespread immunization , improved blood supply testing , and emphasis on safe sex have significantly decreased new HBV infections , the large reservoir of infected individuals ( 400 million ) remains a serious health problem .',
  'With over 170 million individuals chronically infected with hepatitis C virus ( HCV ) worldwide , HCV is currently a serious global health concern , leading to chronic hepatitis , cirrhosis and HCC , thereby causing significant morbidity and mortality .',
  'Hepatitis B infection remains a serious public health problem in northwest China .',
  'Acute and chronic hepatitis C virus ( HCV ) infection remains a serious health problem worldwide , however , there has been advancement in the treatment of HCV infection due to standard treatment using pegylated interferon and ribavirin .',
  'However , since no vaccine exists for hepatitis C and the increased chances for the development of chronic infection hepatitis C will remain a serious health concern .',
  "As one of the world 's most common infectious diseases , hepatitis B virus ( HBV ) is a serious worldwide public health problem , with HBV-associated liver disease accounting for more than half a million deaths each year .",
  'Chronic hepatitis B is a serious and chronic health problem , requiring self-management to control the disease and related complications .',
  'Hepatitis B virus infection is a serious global health problem and causes life-threatening liver disease .',
  'Chronic hepatitis B virus ( HBV ) infection remains a serious global health problem , inducing a spectrum of diseases , including asymptomatic HBV carriage ( ASC ) and chronic hepatitis B ( CHB ) .',
  'Hepatitis B virus ( HBV ) infection is a serious global health problem .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious clinical problem because of its worldwide distribution and possible adverse sequelae .',
  'Hepatitis B virus ( HBV ) is a serious global health problem , and HBV genotype is an important determinant of disease progression and treatment outcome .',
  'From the epidemiological point of view the HIV-1 prevalence is decreasing ; hepatitis C turned out to be a serious medical problem for IVDA .',
  'Chronic hepatitis B virus ( HBV ) infection causes liver cirrhosis and hepatocellular carcinoma and remains a serious health problem worldwide .',
  'Prevalence of hepatitis delta virus ( HDV ) infection in chronic hepatitis B patients in eastern Turkey : still a serious problem to consider .',
  'Hepatitis B infection is a serious global public health problem .',
  'Reactivation of hepatitis B virus ( HBV ) after cytotoxic chemotherapy is a serious problem , and it occurred to 41 % of breast cancer patients carrying HBV .',
  'Though the global epidemiology of hepatitis B virus infection has declined due to effective immunization , chronic hepatitis B ( CHB ) remains a serious public health problem and there is still a need for more treatment options that are efficient , safe and simple for different kinds of CHB patients .',
  'Therefore , HTLV-1 infection is a serious public health concern .',
  'Hepatitis B virus ( HBV ) infection remains to be a serious public health problem in China .',
  'Hepatitis C is a serious problem on the Greek island of Crete , where a high prevalence of antibodies against hepatitis C ( anti-HCV ) has recently been reported .',
  'Hepatitis B is a serious epidemiological problem in uremic patients treated with renal replacement therapy .',
  'Chronic hepatitis B ( CHB ) remains a serious clinical problem worldwide .',
  'Human hepatitis B virus ( HBV ) infection remains a serious health problem worldwide .',
  'Viral hepatitis is a serious public health problem .',
  'Hepatitis B virus ( HBV ) flare is a serious problem following hematopoietic stem cell transplantation ( HSCT ) , and the mortality rate is high if severe hepatitis occurs .',
  'Hepatitis A and B are still a serious global public health problem .',
  'Chronic hepatitis C is a serious global medical problem necessitating effective treatment .',
  'In these areas , the HBV prevalence is still high which makes this virus a serious public health concern to the entire region .',
  'Hepatitis E ( HE ) is a serious problem in developing countries worldwide , affecting in epidemics or as sporadic cases millions of people .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious problem due to its extensive worldwide distribution and poor prognosis including cirrhosis and/or hepatocellular carcinoma .',
  'Hepatitis B ( HBV ) and C ( HCV ) infections are a serious global and national public health problem .',
  'Hepatitis C virus ( HCV ) infection is a serious and significant global health problem in the Pakistan and elsewhere .',
  'Hepatitis B virus ( HBV ) infection is a serious global health problem .',
  'Hepatitis B virus ( HBV ) continues to be a serious worldwide health problem despite the use of protective HBV vaccines and therapeutic regimens against chronic HBV infection .',
  'Hepatitis B constitutes a serious public health problem .',
  'This article is relevant in that it outlines the significant achievements of a dedicated group of individuals to solve a serious public health problem , that of eliminating hepatitis B as a risk for our children .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem in sub-Saharan Africa .',
  'HCV is a serious public health concern requiring screening , education , reduction of disease transmission , and access to care .',
  'Emergence of lamivudine-resistant variants , with amino acid substitutions in the Tyr-Met-Asp-Asp ( YMDD ) motif of hepatitis B virus ( HBV ) reverse transcriptase , is a serious problem in antiviral therapy .',
  'In the liver transplant ( LT ) setting , these regimens are expected to have an important effect , because graft loss due to HCV recurrence is a serious problem after LT .',
  'Viral hepatitis represents a serious public health problem in the world especially in the Maghreb where the prevalence of the 5 viruses A , B , C , D , and E remains high and varies from one Maghreb country to another , there is few published studies on these infections in our Maghreb countries .',
  'Chronic hepatitis C virus ( HCV ) infection is a serious global health problem affecting 150 million individuals worldwide .',
  'Chronic hepatitis B virus ( HBV ) infection due to perinatal mother-to-infant transmission ( MTIT ) remains a serious global health problem .',
  'Hepatitis E virus-mediated infection is a serious public health concern in economically developing nations of the world .',
  'HCV virus infections have become a serious epidemiological problem throughout the world .',
  'Hepatitis B virus ( HBV ) infection is still a serious worldwide problem , and vaccination is the most effective strategy for primary prevention of the infection .',
  'Hepatitis C : a serious public health concern .',
  'Chronic hepatitis C virus ( HCV ) infection is a serious public health problem worldwide .',
  'The emergence of drug-resistant mutants of hepatitis B virus ( HBV ) is a serious problem during antiviral therapy of patients with chronic hepatitis B. Lamivudine-resistant mutants with a mutation in the YMDD motif of reverse transcriptase of HBV emerge in approximately one half of the treated patients within 5 years .',
  'Hepatitis C virus ( HCV ) is a serious public health problem affecting 170 million carriers worldwide .',
  'Hepatitis B is a dreadful infectious disease and a major global health problem .',
  'Hepatitis C virus ( HCV ) infection is a serious public health problem throughout the world .',
  'Human immunodeficiency virus (HIV)/hepatitis C virus ( HCV ) coinfection has become a serious public health problem .',
  'Despite effective vaccination programs in many countries , HBV infection is still a serious health problem throughout the world ; more than 2 billion people have been infected with Hepatitis B virus ( HBV ) .',
  'Infection with hepatitis C virus ( HCV ) is still a serious problem in hemodialysis patients , despite screening of blood products for anti-HCV antibodies .',
  'Individual factors included the perception that untreated HCV infection was not a serious health concern , family responsibilities , and self-perceived discrimination against HCV-infected women .',
  'HBV and HDV infection is still a serious health problem in Southeastern Turkey .',
  'Chronic hepatitis B virus ( HBV ) infection poses a serious public health problem in many parts of the world .',
  'Hepatitis C is a serious public health problem throughout the world ; chronic renal patients are highly exposed to this infection .',
  'Human immunovirus infection among pregnant women continues to be a serious public health concern .',
  'Viral hepatitis is a serious health problem that deserves special attention .',
  'Hepatitis C virus ( HCV ) infection is a serious health problem in Georgia .',
  'The hepatitis C virus ( HCV ) is globally recognized as a serious public health concern .',
  'Hepatitis B infection is a serious health problem in endemic areas particularly among immunocompromised patients .',
  'Hepatitis B represents a serious public health problem in all parts of the world , and particularly in hyperendemic areas , where the majority of infections occur in childhood .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem in many parts of the world .',
  'Hepatitis C virus ( HCV ) represents a serious public health concern .',
  'Viral hepatitis is a serious public health problem affecting billions of people globally .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem worldwide .',
  'Resistance to antiviral therapy remains a serious problem in the management of chronic hepatitis C. In most patients , HCV RNA could be detected in peripheral blood mononuclear cell ( PBMC ) .',
  'Hepatitis B virus ( HBV ) remains a serious worldwide health problem and the possibility to control it will depend on the availability of safe , effective and affordable vaccines .',
  'Chronic HBV infection in kidney , heart , and other organs has become a serious long-term problem and one of the most frequent and important comorbidities affecting graft and patient survival .',
  'Hepatitis B remains a serious public health problem .',
  'We report three cases of fatal INH-associated hepatitis that illustrate that this complication of preventive INH use remains a serious problem .',
  'HBV infection is a serious global health problem , with 2 billion people infected worldwide , and 350 million suffering from chronic HBV infection .',
  'Hepatitis C virus ( HCV ) infection is considered by the World Health Organization ( WHO ) to be a serious public health concern and one of the major public health priorities .',
  'Hepatitis B virus ( HBV ) infection and its sequelae such as cirrhosis and hepatocellular carcinoma has remained a serious public health problem throughout the world .',
  'Hepatitis E caused by hepatitis E virus ( HEV ) is a serious public health concern in developing countries where HEV is mainly transmitted through contaminated water .',
  'Recurrent hepatitis C infection in the posttransplant setting is a serious problem .',
  'Viral Hepatitis B , C and D are a serious public health problem in Brazil and other South American countries , mainly in the Amazonian region .',
  'The results show that HBV infection is a serious problem among the children of mountain aborigines in Hualien , with nearly one-third of them carrying HBsAg .',
  'Hepatitis E virus ( HEV ) is a serious public health problem that causes acute hepatitis in humans and is primarily transmitted through fecal and oral routes .',
  'Hepatitis C virus ( HCV ) infection is a serious global health problem .',
  'Chronic hepatitis B ( CHB ) infection is a serious public health problem due to its potential liver disease sequelae and highly expensive medical costs such as the need for liver transplantation .',
  'HCV infection is a serious public health problem and a leading cause of chronic liver disease .',
  'Hepatitis B virus and Hepatitis C virus infections are among the most common viral infections globally and maintain their position as a serious public health problem .',
  'Hepatitis B induced by HBV is a serious health problem .',
  'Hepatitis C virus ( HCV ) infections are a serious viral health problem globally , causing liver cirrhosis and inflammation that can develop to hepatocellular carcinoma and death .',
  'Currently , hepatitis C is a serious public health problem .',
  'Hepatitis C virus ( HCV ) is a serious global health problem which accounts for approximately 40 % of chronic liver diseases worldwide .',
  'Chronic hepatitis B is a serious public health concern .',
  'Hepatitis B virus ( HBV ) reactivation is a serious clinical problem in HBV carriers undergoing chemotherapy .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem in sub-Saharan Africa pregnant women .',
  'HB is a serious global public health problem and the health professionals are most at risk .',
  'Hepatitis B virus infection is a serious public health problem .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious problem because of its world wide distribution and possible adverse chronic sequalae such as cirrhosis and hepatocellular carcinoma .',
  'Hepatitis B virus ( HBV ) infection is a serious global health problem that is associated with huge social and economic costs .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious public health problem because of its worldwide prevalence and potential to cause adverse consequences .',
  'Hepatitis B ( HB ) is a serious public health problem in China .',
  'Viral hepatitis is a serious public health problem affecting billions of people globally with maternal-fetal transmission on the rise .',
  'Hepatitis C virus ( HCV ) recurrence is a serious problem after orthotopic liver transplantation ( OLT ) .',
  'Persistent BHHV among nurses is a serious concern .',
  'Viral hepatitis is a serious problem worldwide that was under-recognized till recently .',
  'Hepatitis B virus ( HBV ) infection causing acute and chronic hepatitis is a serious problem worldwide , whereas the current treatment methods are unsatisfactory .',
  'Hepatitis B virus ( HBV ) infection is a severe health problem in the world ; however , there is still no satisfactory therapeutic strategy for the HBV infection .',
  'Hepatitis B virus ( HBV ) infection is a severe health problem all over the world .',
  'In Pakistan , viral hepatitis is a serious public health problem affecting millions of people .',
  'Hepatitis C virus ( HCV ) recurrence after liver transplantation ( LT ) used to be a serious problem in the era of interferon-based treatment .',
  'Hepatitis C virus ( HCV ) represents a serious worldwide healthcare problem .',
  'Hepatitis E is a serious public health problem in developing countries .',
  'Viral fulminant hepatitis ( FH ) remains a serious clinical problem with very high mortality .',
  'Hepatitis B virus ( HBV ) is a serious global health problem .',
  'Hepatitis B virus ( HBV ) remains a serious public health problem worldwide , accounting for high morbidity and mortality rates as well as significant personal , societal , and economic costs .',
  'Chronic hepatitis C ( CHC ) is a serious clinical problem .',
  'Despite the introduction of universal vaccination against hepatitis B in over 100 countries , persistent HBV infection is still a serious problem worldwide , causing an estimated annual death rate of one million .',
  'HBV infection is a serious public health problem worldwide , which can contribute to the incidence of chronic hepatitis B ( CHB ) , cirrhosis , and hepatocellular carcinoma ( HCC ) .',
  'Despite its significantly higher prevalence , hepatitis C , now a serious public health problem , has long been overshadowed by HIV infection in France .',
  'Hepatitis B virus ( HBV ) infection constitutes a serious global health problem .',
  'Hepatitis C virus ( HCV ) infection is a serious health problem world-wide .',
  'Hepatitis B virus infection is a serious health problem worldwide , and more than 350 million people are chronic carriers , constituting a major global threat .',
  'Hepatitis C virus ( HCV ) infection is a serious global health problem .',
  'Hepatitis B virus ( HBV ) infection remains a severe clinical concern in China .',
  'Infection with Hepatitis B virus ( HBV ) is a serious public health problem worldwide , with over 360 million carriers .',
  'This is a serious public health problem and challenge for a country with high prevalence of hepatitis B infection .',
  'Hepatitis B virus ( HBV ) infection is a serious , world-wide problem .',
  'Severe haemorrhagic thrombocytopenia in infectious mononucleosis with positive Epstein-Barr virus ( EBV ) serology remains a threatening clinical problem .',
  'Hepatitis B virus ( HBV ) infection is one of the most prevalent viral infections in humans and represents a serious public health problem .',
  'Chronic hepatitis B ( CHB ) is a serious public health problem , and Traditional Chinese Medicine ( TCM ) plays an important role in the control and treatment for CHB .',
  'Hepatitis-B infection is not commonly perceived as a serious medical problem in Nigeria .',
  'Hepatitis B virus ( HBV ) infection is a serious clinical problem affecting approximately 2 billion people worldwide .',
  'Hepatitis B virus ( HBV ) infection is a severe health problem , especially in developing countries .',
  'There are more than 100 million asymptomatic HBV carriers ( ASCs ) in China and they are at a high risk of developing liver disease , which creates a serious health problem .',
  'Hepatitis B virus ( HBV ) infection remains a severe public health problem .',
  'The presence of HAV in water samples constitutes a serious public health problem .',
  'Hepatitis B virus ( HBV ) infection is known as a serious problem in the domain of public health and approximately 350 million people across the world are affected with this infectious disease .',
  'Hepatitis B is a serious public health problem leading to chronic infection , liver cirrhosis , and hepatocellular carcinoma .',
  'Chronic hepatitis B is one of the most frequent infectious disease in the world and represents a serious problem of public health',
  'Chronic hepatitis B virus ( HBV ) infection , a serious public health problem leading to cirrhosis and hepatocellular carcinoma , is currently treated with either pegylated alpha interferon ( pegIFN-α ) or one of the five nucleos(t)ide analogue viral DNA polymerase inhibitors .',
  'Persistent hepatitis C virus ( HCV ) infection causes chronic liver diseases and is a serious global health problem .',
  'The global epidemic of hepatitis B and hepatitis C is a serious publichealth problem .',
  'Hepatitis C virus (HCV)/human immunodeficiency virus ( HIV ) co-infection has become a serious public health problem especially in high risk groups such as injection drug users in China .',
  'Non-A , non-B ( type C ) hepatitis is a serious world problem which typically results in chronic hepatitis and may lead to cirrhosis and hepatocellular carcinoma .',
  'Hepatitis E virus has emerged as a serious problem after solid organ transplantation ( SOT ) , leading to diverse extrahepatic manifestations and chronic hepatitis with unfavorable outcomes .',
  'These results indicate that hepatitis B is a serious problem of public health in our country that merit to take immediate prophylactic measures .',
  'HB is still a serious health problem in economically compromised parts of the world .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem worldwide .',
  'However , the recurrence of HCC after transplantation remains a serious problem that affects about 20 % of post-transplant cases .',
  'Hepatitis B virus ( HBV ) infection is a serious global health problem .',
  'Hepatitis B virus ( HBV ) infection is a serious global health problem .',
  'Chronic hepatitis B continues to be a serious problem worldwide .',
  'Infections by HCV represent a serious global health problem , because millions of people worldwide are infected and no efficient treatment is available at the present time .',
  'Viral hepatitis B , C and delta still remain a serious problem in Latin America .',
  'Hepatitis B virus ( HBV ) infection is a major risk for hepatocellular carcinoma ( HCC ) , and it is a serious global health problem with two billion people exposed to it worldwide .',
  'Chronic hepatitis B ( CHB ) is a serious health problem in Korea .',
  'Hepatitis B virus ( HBV ) infection is a serious global public health problem .',
  'Hepatitis C virus ( HCV ) infection is a serious public health problem because of its worldwide diffusion and sequelae .',
  'However , for patients who have genetic diseases which predispose them to the development of hemophagocytic lymphohistiocytosis ( HLH ) , EBV infection is a life-threatening problem .',
  'Hepatitis B virus ( HBV ) infections are a serious health problem in the United States , where approximately 18,000 cases are reported each year to the Centers for Disease Control .',
  'Viral hepatitis is a serious health problem all over the world .',
  'Hepatitis B is a serious global health problem .',
  'Chronic hepatitis B ( CHB ) infection is a serious and prevalent health concern worldwide , and the development of effective drugs and strategies to combat this disease is urgently needed .',
  'Viral hepatitis is a serious medical and economic problem .',
  'It imposes a serious problem to public health in the world as the population of chronically infected HCV patients who are at risk of progressive liver disease is projected to increase significantly in the next decades .',
  'HBV infection is a serious global heath problem .',
  'Hepatitis B is a severe public health problem .',
  'Hepatitis B ( HB ) is a serious global public health problem .',
  'Hepatitis E outbreaks are a serious public health concern in developing countries .',
  'Hepatitis C is a disease that constitutes a serious global health problem , is often asymptomatic and difficult to diagnose and about 60 - 80 % of infected patients develop chronic diseases over time .',
  'On the last twenty years , viral hepatitis has emerged as a serious problem in almost all the Amerindian communities studied in the Amazon Basin and in other Amazon-related ecological systems from the North and Center of South America .',
  'Hepatitis B is a serious public health problem in China .',
  'HDV infection still remains a serious public health problem in Amazonia .',
  'Vietnamese males have the highest incidence of liver cancer of any ethnic group , and HBV infection is a serious and prevalent health problem among Vietnamese immigrants .',
  'Hepatitis C virus ( HCV ) infection is a serious global health problem , with 3 - 4 million new cases reported each year .',
  "Hepatitis C Virus ( HCV ) is a serious global health problem , infecting almost 3 % of the world 's population .",
  'Hepatitis B is a serious public health problem across sub-Saharan Africa .',
  'Hepatitis C virus ( HCV ) remains a serious global health problem that lacks an effective cure .',
  'Hepatitis B , a disease entity currently affecting more than 350 million persons worldwide , is also a serious health problem in Taiwan .',
  'Hepatitis C virus ( HCV ) infection is a serious public health problem .',
  'Chronic hepatitis C virus ( HCV ) infection is a serious health problem in Taiwan .',
  'Viral hepatitis is a serious global public health problem affecting billions of people globally , and both hepatitis B virus ( HBV ) and hepatitis C virus ( HCV ) infections are rapidly spreading in the developing countries including Bangladesh due to the lack of health education , poverty , illiteracy and lack of hepatitis B vaccination .',
  'Hepatitis D caused by the hepatitis delta virus ( HDV ) is a serious health problem in many regions of the world .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious problem owing to its worldwide distribution and potential adverse sequelae that include cirrhosis and/or hepatocellular carcinoma .',
  'Hepatitis C virus ( HCV ) infection represents a serious public health problem worldwide .',
  'Chronic hepatitis B ( CHB ) virus ( HBV ) infection remains a severe problem worldwide .',
  'Hepatitis B , hepatitis C , and HIV infections are a serious global and public health problem .',
  'Hepatitis C virus ( HCV ) infection is a serious public health problem , that affects approximately 170 million people worldwide .',
  'Chronic hepatitis B is a serious health problem worldwide .',
  'In North African countries , HCV seems to be a serious problem that is driven by different vectors even in different geographical locations within the same country .',
  'Hepatitis C recurrence after liver transplantation is a serious problem , leading to increased graft loss and morbidity in some individuals .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious clinical problem because of its world-wide distribution and potential adverse sequelae .',
  'Hepatitis C virus infection is a serious public health problem .',
  'Hepatitis B is a serious public health problem throughout the world .',
  'Hepatitis A virus ( HAV ) still continues to be a serious public health problem worldwide .',
  'Hepatitis B virus ( HBV ) reactivation from resolved infection is a serious problem which can frequently lead to severe hepatitis .',
  'Hepatitis C virus ( HCV ) infection remains a serious public health problem worldwide .',
  'Hepatitis delta ( HDV ) virus still poses a serious health problem worldwide .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem , which can be transmitted through various routes ( e.g. , blood donation ) and cause hepatitis , liver cirrhosis and liver cancer .',
  'Hepatitis C virus ( HCV ) , the major etiological agent of transfusion-associated non-A , non-B hepatitis , is a severe health problem affecting up to 3 % of the world population .',
  "Chronic infection with hepatitis C virus ( HCV ) is a serious public health problem affecting an estimated 2 % of the world 's population .",
  'Fulminant viral hepatitis ( FH ) remains a serious clinical problem for which the underlying pathogenesis remains unclear .',
  'Perinatal transmission of hepatitis B virus continues to be a serious global public health concern .',
  'Hepatitis C virus ( HCV ) is a serious global health problem and establishes chronic infection in a significant number of infected humans worldwide .',
  'Infection by hepatitis C viruses ( HCVs ) is a serious medical problem with no broadly effective treatment available for the progression of chronic hepatitis .',
  'Hepatitis B virus ( HBV ) , a serious infectious and widespread human pathogen , represents a major health problem worldwide .',
  'These results demonstrate the high and increasing rate of HTLV-III infection among groups at risk for AIDS , and suggest that HTLV-III-related diseases will be a serious problem in the years ahead .',
  'Although a majority of countries in the Middle East show intermediate or high endemicity of hepatitis B virus ( HBV ) infection , which clearly poses a serious public health problem in the region , the situation in the Republic of Syria remains unclear .',
  'Drug resistance remains a serious problem that limits the effectiveness of US Food and Drug Administration (FDA)-approved direct-acting antiviral ( DAA ) drugs against HCV proteins .',
  'Hepatitis C virus ( HCV ) infection is a serious health problem leading to cirrhosis , liver failure and hepatocellular carcinoma .',
  'Hepatitis B virus ( HBV ) infection is a serious health problem in the developing countries including Pakistan .',
  'Chronic hepatitis B virus ( HBV ) infection remains a serious global health concern .',
  'Hepatitis B virus ( HBV ) infection is a serious global public health problem affecting billions of people globally .',
  'The burden of hepatitis B virus ( HBV ) infection is a serious public health problem all over the world .',
  'Hepatitis B virus ( HBV ) infection is still a serious public health problem .',
  'Chronic hepatitis C infection is a serious therapeutic problem .',
  'Chronic forms of viral B , C and D hepatitis and fulminant hepatitis represent a serious healthcare problem .',
  'Type A hepatitis virus ( HAV ) is a serious health problem throughout the world and can be spread via fecal-oral contact .',
  'Among patients with renal insufficiency undergoing chronic dialysis treatment , chronic hepatitis due to infection with viruses of the hepatitis B ( HBV ) or hepatitis C ( HCV ) type represents a serious medical problem .',
  'Hepatitis E virus ( HEV ) infection is an emerging disease with zoonotic transmission that represents a serious public health concern , especially in developing countries .',
  'HBV infection is a serious public health problem among adult population in Henan .',
  'Hepatitis C virus (HCV)-mediated chronic liver disease is a serious health problem around the world and often causes fibrosis/cirrhosis and hepatocellular carcinoma .',
  'Chronic hepatitis B virus ( HBV ) infection is a serious problem because of its worldwide distribution and possible adverse sequelae , such as cirrhosis and hepatocellular carcinoma .',
  'Hepatitis delta virus ( HDV ) infection is a serious health problem worldwide .',
  'Hepatitis B virus ( HBV ) infection is a serious clinical problem worldwide .',
  'Hepatitis A virus ( HAV ) infection is one of the most common causes of acute hepatitis and it is a serious health problem worldwide .',
  'Recurrence of Hepatitis B Virus infection in patients undergoing liver transplanted ( LT ) is a serious and often fatal problem .',
  'Infectious hepatitis is a serious problem affecting millions of people worldwide , particularly in China and other developing countries , and it is the major risk factor for hepatic cirrhosis .',
  'Chronic hepatitis C ( CHC ) is a serious medical problem necessitating more effective treatment .',
  'Chronic hepatitis C ( HCV ) infection is a serious problem all over the world and has a special importance in Egypt , where the prevalence of infection is 14.7 % of population .',
  'Infection with hepatitis C virus is a serious worldwide health problem .',
  'Hepatitis B virus ( HBV ) infection is a serious health problem worldwide .',
  'Hepatitis C ( HCV ) viral infection is a serious medical problem in Egypt and it has a devastating impact on the Egyptian economy .',
  'Hepatitis C virus ( HCV ) infections are a serious global-scaled public health problem .',
  'Hepatitis C virus ( HCV ) infections caused by occupational percutaneous injuries are a serious problem for healthcare workers and there has been a gradual increase in the number of HCV infections .',
  'hepatitis B virus ( HBV ) reactivation in immunocompromised states is a well-known event that may be a serious problem in endemic areas of infection .',
  'HCV ( hepatitis C virus ) infection is a serious health care problem that affects more than 170 million people worldwide .',
  'Hepatitis B virus ( HBV ) infection is a serious public health problem in China and worldwide .',
  'Viral hepatitis is a serious health problem all over the world .',
  'Chronic hepatitis B virus ( HBV ) infection represents a serious global health problem and resistance to lamivudine ( LAM ) has become a serious clinical challenge .',
  'Hepatitis B virus ( HBV ) infection remains a serious public health concern worldwide .',
  'Hepatitis B virus infection is a serious problem globally , and particularly in the Western Pacific Region where the population suffers disproportionately from the infection and its sequelae .',
  'Infections with Hepatitis C virus ( HCV ) pose a serious health problem worldwide .',
  'The hepatitis C is a severe public health problem worldwide because its consequences .',
  'Hepatitis E virus ( HEV ) is a serious public health problem .',
  'Despite an effective vaccine , HBV poses a serious health problem globally , accounting for 257 million chronic carriers .',
  'Chronic hepatitis in children represents a serious health and social problem .',
  'Recurrent hepatitis C after liver transplantation is a serious problem faced by liver transplant recipients .',
  'Hepatitis B virus ( HBV ) infection is a serious global health problem , with 2 billion people infected worldwide , and 350 million suffering from chronic HBV infection .',
  'Recurrent hepatitis C virus ( HCV ) has been a serious problem after liver transplantation ( LT ) .',
  'Hepatitis B virus ( HBV ) and hepatitis C virus ( HCV ) infections are a serious global public health problem affecting billions of people .'],
 'eeg': ["The problem with this first-order analysis is that there exists a broad class of ' microbalanced ' stimuli in which the motion or slant is completely obvious to human subjects but is invisible to first-order analysis .",
  'A common problem with this approach is that the state of the cortex ( defined in part by level of anesthesia and number of active cells ) changes during the time required to generate these maps .',
  'A problem with the topographic mapping of MEG data recorded with axial gradiometers is that field extrema are measured at sensors located at either side of a neuronal generator instead of at sensors directly above the source .',
  'A notorious problem with EEG is that genuine cerebral data is often contaminated by artifacts of non-cerebral origin .',
  'One problem with such localizations is that in many patients , the localization of an epileptic spike source becomes inaccurate because the epileptic spikes are superimposed by pathologic brain rhythmic activities .',
  'When characterizing regional cerebral gray matter differences in structural magnetic resonance images ( sMRI ) by voxel-based morphometry ( VBM ) , one faces a known drawback of VBM , namely that histogram unequalization in the intensity images introduces false-positive results .',
  'A major drawback of functional Magnetic Resonance Imaging ( fMRI ) concerns the lack of detection accuracy of the measured signal .',
  'A drawback of this layout is its visual clutter for multichannel EEG .',
  'A major drawback of this method is that it requires a model of the nerve , and that the localization performance is highly dependent on the accuracy of this model .',
  'Though independent component analysis ( ICA ) is a powerful method to overcome certain limitations , ICA has a serious problem in that the number of single-electrodes ( microwires ) must be more than the number of single-neurons to be recorded .',
  'Interactions of forward masking and simultaneous masking present a serious problem for a clear interpretation of these results .',
  'False detections due to non-epileptiform rhythmic EEG bursts and to artefacts were quite frequent but were not a serious problem because they did not unduly lengthen the EEG tracing and they could be easily identified by the electroencephalographer .',
  'Functional Magnetic Resonance Imaging inherently involves noisy measurements and a severe multiple test problem .',
  'Overt articulation produces strong artifacts in the electroencephalogram and in event-related potentials ( ERPs ) , posing a serious problem for investigating language production with these variables .',
  'The presence of high levels of background noise is a serious concern for functional magnetic resonance imaging studies of phonological processing using conventional methods .',
  'When the stimulus consisted of a pair of vertical columns of dots , efficiency was also generally constant as noise was increased , perhaps because such stimuli do not present a severe correspondence problem .',
  'Artefactor unreliability is a serious problem in the delta band because of disagreement on eye movement artefacts .',
  'A serious dilemma , among other problems , is that the fMRI signal generally represents a temporal integral over several seconds : The knowledge that a certain brain region was active sometime or other is not necessarily helpful for disentangling the MEG activity within a specified short time window .',
  'The discrimination of single unit activity in extracellular recordings presents a serious problem when the signal-to-noise ratio is low or when the amplitudes of interspersed spikes are similar .',
  'Our results demonstrate that eye-movement related contamination of brain signals constitutes a severe problem for decoding motor signals from EEG data .'],
 'membrane': ['A significant problem with respect to this type of pollution is that it decreases energy yield .',
  'Functionalized membranes containing nanoparticles provide a novel platform for organic pollutant degradation reactions and for selective removal of contaminants without the drawback of potential nanoparticle loss to the environment .',
  "However , a drawback of today 's dominating process is the need for large amounts of highly toxic hydrogen cyanide .",
  'A drawback of this approach is that toxic Hg is released back into the environment .',
  'A key drawback of the current processing methods includes the generation of large amounts of toxic and radioactive waste .',
  'A drawback of this treatment is the use of pollutant chemicals .',
  'Nonetheless , a major drawback of small scale biomass gasifiers is the relatively poor quality of the producer gas .',
  'The purpose of the present study is to reduce fouling formation , a fatal problem of membrane technology by means of surface-coating with a functional coating material , i.e. , hydrophilic polyvinyl alcohol ( PVA ) polymer .',
  'As the cake resistance of the membrane caused a serious problem , a stainless-steel prefilter and air backwashing methods were applied to minimize the cake resistance effectively .',
  'Membrane fouling is a severe problem hampering the application of membrane separation technology .',
  'This indicates that fouling could be a severe problem for membrane distillation performance .',
  'The fouling of surfaces submerged in a liquid is a serious problem for many applications including lab-on-a-chip devices and marine sensors .',
  'Bio-fouling is a serious problem in many membrane-based separation processes for water and wastewater treatment .',
  'A serious problem often encountered in its practice is carryover contamination from products of previous 3SR reactions .',
  "Water pollution is a serious concern for public health and environment in today 's world ; hence , there exists a strong demand to develop cost-effective , sustainable and eco-friendly membranes .",
  'Biofouling is a serious problem in reverse osmosis/nanofiltration ( RO/NF ) applications , reducing membrane performance .',
  'Polysulfone ( PSf ) membrane has been widely used in water separation and purification , although , membrane fouling is still a serious problem limiting its potential .',
  'Membrane fouling is a serious concern in municipal wastewater treatment using nanofiltration ( NF ) .',
  'Oxygen buildup would be a serious problem with any enclosed reactor , especially small-diameter tubes .',
  'However , membrane fouling is a serious problem because the foulant , which causes the membrane to foul , may get rejected by the membrane and accumulate in the reactor , resulting in an acceleration of membrane fouling .',
  'Biofouling is a severe problem in membrane systems which hampers their broad applications because it requires regular chemical cleaning , reduces membrane life , and also decreases product quality .',
  'The erratic behaviour of cavitational activity exhibited in a sonochemical reactor pose a serious problem in the efficient design and scale-up ; thus it becomes important to identify the active and passive zones existing in the reactor so as to enable proper placement of the reaction mixtures for achieving maximum benefits .',
  'Al3 + contamination may thus be a serious problem when using this apparatus .',
  'Membrane biofouling remains a severe problem to be addressed in wastewater treatment systems affecting reactor performance and economy .',
  'Biofouling is a serious problem on filter membranes of water purification systems due to formation of bacterial biofilms , which can be detrimental to the membrane performance .',
  'Silica scaling of membranes used in reverse osmosis desalination processes is a severe problem , especially during the desalination of brackish groundwater due to high silica concentrations .',
  'Foaming in the large fermenter also presented a serious problem , which must be solved before low-pressure airlift fermenters become practical .',
  'The quantities in which they are produced are also a serious problem .',
  'However , fouling of RO membranes has been a severe problem and key limiting factor in the widespread application of the RO process .',
  'However , in a pressure-driven membrane separation process ( i.e. , filtration ) , membrane fouling caused by adhesion of plasma proteins is a severe problem .',
  'Amphiphilic zwitterionic copolymers have a severe problem of solubility , which restricts the feasibility and development of antifouling coatings .'],
 'membranes': ['A significant problem with respect to this type of pollution is that it decreases energy yield .',
  'Functionalized membranes containing nanoparticles provide a novel platform for organic pollutant degradation reactions and for selective removal of contaminants without the drawback of potential nanoparticle loss to the environment .',
  "However , a drawback of today 's dominating process is the need for large amounts of highly toxic hydrogen cyanide .",
  'A drawback of this approach is that toxic Hg is released back into the environment .',
  'A key drawback of the current processing methods includes the generation of large amounts of toxic and radioactive waste .',
  'A drawback of this treatment is the use of pollutant chemicals .',
  'Nonetheless , a major drawback of small scale biomass gasifiers is the relatively poor quality of the producer gas .',
  'The purpose of the present study is to reduce fouling formation , a fatal problem of membrane technology by means of surface-coating with a functional coating material , i.e. , hydrophilic polyvinyl alcohol ( PVA ) polymer .',
  'As the cake resistance of the membrane caused a serious problem , a stainless-steel prefilter and air backwashing methods were applied to minimize the cake resistance effectively .',
  'Membrane fouling is a severe problem hampering the application of membrane separation technology .',
  'This indicates that fouling could be a severe problem for membrane distillation performance .',
  'The fouling of surfaces submerged in a liquid is a serious problem for many applications including lab-on-a-chip devices and marine sensors .',
  'Bio-fouling is a serious problem in many membrane-based separation processes for water and wastewater treatment .',
  'A serious problem often encountered in its practice is carryover contamination from products of previous 3SR reactions .',
  "Water pollution is a serious concern for public health and environment in today 's world ; hence , there exists a strong demand to develop cost-effective , sustainable and eco-friendly membranes .",
  'Biofouling is a serious problem in reverse osmosis/nanofiltration ( RO/NF ) applications , reducing membrane performance .',
  'Polysulfone ( PSf ) membrane has been widely used in water separation and purification , although , membrane fouling is still a serious problem limiting its potential .',
  'Membrane fouling is a serious concern in municipal wastewater treatment using nanofiltration ( NF ) .',
  'Oxygen buildup would be a serious problem with any enclosed reactor , especially small-diameter tubes .',
  'However , membrane fouling is a serious problem because the foulant , which causes the membrane to foul , may get rejected by the membrane and accumulate in the reactor , resulting in an acceleration of membrane fouling .',
  'Biofouling is a severe problem in membrane systems which hampers their broad applications because it requires regular chemical cleaning , reduces membrane life , and also decreases product quality .',
  'The erratic behaviour of cavitational activity exhibited in a sonochemical reactor pose a serious problem in the efficient design and scale-up ; thus it becomes important to identify the active and passive zones existing in the reactor so as to enable proper placement of the reaction mixtures for achieving maximum benefits .',
  'Al3 + contamination may thus be a serious problem when using this apparatus .',
  'Membrane biofouling remains a severe problem to be addressed in wastewater treatment systems affecting reactor performance and economy .',
  'Biofouling is a serious problem on filter membranes of water purification systems due to formation of bacterial biofilms , which can be detrimental to the membrane performance .',
  'Silica scaling of membranes used in reverse osmosis desalination processes is a severe problem , especially during the desalination of brackish groundwater due to high silica concentrations .',
  'Foaming in the large fermenter also presented a serious problem , which must be solved before low-pressure airlift fermenters become practical .',
  'The quantities in which they are produced are also a serious problem .',
  'However , fouling of RO membranes has been a severe problem and key limiting factor in the widespread application of the RO process .',
  'However , in a pressure-driven membrane separation process ( i.e. , filtration ) , membrane fouling caused by adhesion of plasma proteins is a severe problem .',
  'Amphiphilic zwitterionic copolymers have a severe problem of solubility , which restricts the feasibility and development of antifouling coatings .'],
 'cardiotoxicity': ['The major problem with emetine is that chronic use causes severe cardiotoxicity .',
  'Cardiotoxicity is a major drawback of anticancer therapies , often hindering optimal management of cancer .',
  'A serious drawback of tumor necrosis factor alpha ( TNF ) as a clinical antitumor agent is that it also has hypotensive activity .',
  'Cardiac side effects are a major drawback of anticancer therapies , often requiring the use of low and less effective doses or even discontinuation of the drug .',
  'Recent developments of novel targeted therapies are contributing to the increased long-term survival of cancer patients ; however , drug-induced cardiotoxicity induced by cancer drugs remains a serious problem in clinical settings .',
  'Nevertheless , ponatinib-induced vascular toxicity remains a serious concern , with underlying mechanisms being poorly understood .',
  'Anthracycline-induced cardiotoxic effects are a serious problem among young patients who survive childhood cancer and there is an urgent need to avoid such effects .',
  'Cardiac dysfunction is often observed in patients with cancer also representing a serious problem limiting chemotherapeutic intervention and even patient survival .',
  'Drug-induced vascular injury ( DIVI ) is a serious problem in preclinical studies of vasoactive molecules and for survivors of pediatric cancers .',
  'The risk of cardiovascular toxicities is a serious concern with the increased application of angiogenesis inhibitors in current cancer therapy .',
  'This phenomenon translates into anthracycline cardiotoxicity that is a serious problem in the growing population of paediatric and adult cancer survivors .',
  'Progressive multifocal leukoencephalopathy ( PML ) associated with natalizumab treatment continues to be a severe problem of clinically successful therapy .',
  'Cardiovascular side-effects of modern anticancer drugs can be a serious problem and need careful attention , prevention , or treatment .',
  'Cardiotoxicity remains a serious problem in anthracycline-treated oncologic patients .',
  'Malignant pericardial disease is a serious and common problem seen in patients with cancer .',
  'Drug-induced cardiotoxicity is a serious problem associated with the administration of many drugs .',
  'Asymptomatic anthracycline-induced cardiac damage ( A-CD ) is a serious problem among young childhood cancer survivors .',
  'Cardiotoxicity is known as a severe clinical problem in oncological practice that reduces the options for cancer therapy .',
  'Adriamycin extravasation is a serious problem that can lead to severe local necrosis and damage to underlying nerves , tendon , and muscle .',
  'Extravasation tissue injury from chemotherapeutic drugs is a serious clinical problem .',
  'Doxorubicin cardiotoxicity remains a serious problem in children with malignancy .',
  'Anthracycline cardiotoxicity remains a serious problem in paediatric and adult cancer survivors , and the advancement of cardio-oncology is a necessary step for an effective care of the patients that experience adverse cardiovascular effects .',
  'In the field of hematology , there is a serious concern about cardiovascular complications associated with a variety of chemotherapeutic drugs , such as anthracyclines , BCR-ABL tyrosine kinase inhibitors , and proteasome inhibitors .',
  'Trastuzumab is generally well tolerated although cardiotoxicity has been observed , especially when in combination with doxorubicin ( Adriamycin ) , where this can be a serious concern .',
  'Cardiotoxicity of anthracydines is a serious clinical problem , and it is the main factor limiting their wide use , despite the recognized antineoplastic properties of anthracyclines .',
  'Development of progressive multifocal leukoencephalopathy , a serious brain infection associated with natalizumab ( an α4β7 and α4β1 integrin antagonist ) , has raised concern that vedolizumab may convey a similar risk .',
  'Transient hypotension after infusion of amrinone was a serious clinical problem .'],
 'anthracycline': ['The major problem with emetine is that chronic use causes severe cardiotoxicity .',
  'Cardiotoxicity is a major drawback of anticancer therapies , often hindering optimal management of cancer .',
  'A serious drawback of tumor necrosis factor alpha ( TNF ) as a clinical antitumor agent is that it also has hypotensive activity .',
  'Cardiac side effects are a major drawback of anticancer therapies , often requiring the use of low and less effective doses or even discontinuation of the drug .',
  'Recent developments of novel targeted therapies are contributing to the increased long-term survival of cancer patients ; however , drug-induced cardiotoxicity induced by cancer drugs remains a serious problem in clinical settings .',
  'Nevertheless , ponatinib-induced vascular toxicity remains a serious concern , with underlying mechanisms being poorly understood .',
  'Anthracycline-induced cardiotoxic effects are a serious problem among young patients who survive childhood cancer and there is an urgent need to avoid such effects .',
  'Cardiac dysfunction is often observed in patients with cancer also representing a serious problem limiting chemotherapeutic intervention and even patient survival .',
  'Drug-induced vascular injury ( DIVI ) is a serious problem in preclinical studies of vasoactive molecules and for survivors of pediatric cancers .',
  'The risk of cardiovascular toxicities is a serious concern with the increased application of angiogenesis inhibitors in current cancer therapy .',
  'This phenomenon translates into anthracycline cardiotoxicity that is a serious problem in the growing population of paediatric and adult cancer survivors .',
  'Progressive multifocal leukoencephalopathy ( PML ) associated with natalizumab treatment continues to be a severe problem of clinically successful therapy .',
  'Cardiovascular side-effects of modern anticancer drugs can be a serious problem and need careful attention , prevention , or treatment .',
  'Cardiotoxicity remains a serious problem in anthracycline-treated oncologic patients .',
  'Malignant pericardial disease is a serious and common problem seen in patients with cancer .',
  'Drug-induced cardiotoxicity is a serious problem associated with the administration of many drugs .',
  'Asymptomatic anthracycline-induced cardiac damage ( A-CD ) is a serious problem among young childhood cancer survivors .',
  'Cardiotoxicity is known as a severe clinical problem in oncological practice that reduces the options for cancer therapy .',
  'Adriamycin extravasation is a serious problem that can lead to severe local necrosis and damage to underlying nerves , tendon , and muscle .',
  'Extravasation tissue injury from chemotherapeutic drugs is a serious clinical problem .',
  'Doxorubicin cardiotoxicity remains a serious problem in children with malignancy .',
  'Anthracycline cardiotoxicity remains a serious problem in paediatric and adult cancer survivors , and the advancement of cardio-oncology is a necessary step for an effective care of the patients that experience adverse cardiovascular effects .',
  'In the field of hematology , there is a serious concern about cardiovascular complications associated with a variety of chemotherapeutic drugs , such as anthracyclines , BCR-ABL tyrosine kinase inhibitors , and proteasome inhibitors .',
  'Trastuzumab is generally well tolerated although cardiotoxicity has been observed , especially when in combination with doxorubicin ( Adriamycin ) , where this can be a serious concern .',
  'Cardiotoxicity of anthracydines is a serious clinical problem , and it is the main factor limiting their wide use , despite the recognized antineoplastic properties of anthracyclines .',
  'Development of progressive multifocal leukoencephalopathy , a serious brain infection associated with natalizumab ( an α4β7 and α4β1 integrin antagonist ) , has raised concern that vedolizumab may convey a similar risk .',
  'Transient hypotension after infusion of amrinone was a serious clinical problem .'],
 'psychiatric': ['A major problem with the evidence is that aggression is frequently reported only as one of the items contributing to the total score on a scale or a subscale .',
  'Crime victimisation is a serious problem in Dutch severely mentally ill outpatients .',
  'Assaultive behavior by patients is a serious problem throughout healthcare facilities .',
  'Aggression is a serious problem for both individuals and society .',
  'Physical assaults perpetrated by patients in psychiatric hospitals against mental health staff ( MHS ) is a serious concern facing psychiatric hospitals .',
  'Violence is a serious problem in psychiatric services and staff experience significant psychological reactions to being assaulted . Health and Safety Authorities in the UK and Ireland have expressed concern about violence and assault in healthcare , however , there remains a lack of clarity on matters of procedure and policy pertaining to safety and security in psychiatric hospitals .',
  'Aggressive behavior in schizophrenic patients , although infrequent , is a serious problem .',
  'Patients with recurrent pathologic aggressive behavior constitute a severe problem for psychiatric institutions .',
  'The pharmacological treatment of acute , persisting and repetitive aggression is a serious problem for other patients and staff members .',
  'Anger and anger regulation problems that result in aggressive behaviour pose a serious problem for society .',
  'Aggression is a serious medical problem that can place both the patient and the health care provider at risk .',
  'Patient aggression is a serious problem in psychiatric nursing .',
  'Violence by patients is a serious concern in psychiatric hospitals and staff are the most frequent targets of physical and verbal assault .',
  'Psychiatric patient assaults on staff are a serious problem , affecting staff , patients , and organizations .',
  'The authors examined levels of force used by officers with or without CIT training and disposition decisions in a large sample of encounters with individuals whom they suspected of having a serious mental illness , a drug or an alcohol problem , or a developmental disability .',
  '1 . Assault directed against psychiatric staff is emerging as a serious occupational health problem .',
  'The majority of referees ( n = 632 ) indicated that violence is a serious concern to both players and referees at all levels of hockey .',
  "Psychiatric boarding , defined as psychiatric patients ' waiting in hallways or other emergency room areas for inpatient beds , is a serious problem nationwide .",
  'Crime victimisation is a serious problem in psychiatric patients .',
  'Traumatic victimization , particularly sexual abuse , is a serious problem in correctional facilities and those suffering from mental illnesses are especially vulnerable .',
  'While all of these provide some rationale for eschewing aggression research , aggression remains a serious social , economic , health , and political problem .',
  'Violence against mental health service personnel is a serious workplace problem and one that appears to be increasing .',
  'Violence among psychiatric patients , while uncommon , is a serious problem mental health professionals must face .',
  'Homicide-related mental health difficulties are a serious problem worldwide , displaying high rates of lifetime incidence , high chronicity , and role impairment .',
  'The pharmacological treatment of acute , persisting and repetitive aggression is a serious problem for other patients and staff members .',
  'Violence is a serious concern in the psychiatric inpatient and emergency setting .',
  'Psychiatric patient boarding in emergency department ( ED ) is a severe and growing problem .',
  'Aggressive behaviour is a serious threat to the personal safety and property of others due to the potential that the assailant may hurt people , himself/herself or objects , and aggression has always been one of the focuses of research and concern .',
  'The nature , severity and health impact of this violence represents a serious safety concern for mental health employees .',
  'Even though this study focused only on serious incidents and defined recidivism narrowly , it found that recidivism of violence and aggression among psychiatric patients was a serious problem .',
  'Patients absconding from psychiatric hospitals pose a serious concern for the safety of patients and public alike .',
  'These findings point to violence as a serious and prevalent problem among individuals with BPD , for whom targeted violence reduction strategies that take into account ASPD and psychopathic co-morbidity must be developed .',
  'Psychiatric patient assaults on staff are a serious and continuing problem in health care settings .',
  "Research has demonstrated that psychiatric patient 's assaults on emergency services personnel providing onsite , prehospital care represent a serious and ongoing nationwide concern .",
  'Aggression continues to be a serious problem among children , especially those children who have experienced adverse life events such as maltreatment .',
  'Aggression in children and adolescents is a serious problem and is associated with various psychiatric disorders , not just conduct and oppositional defiant disorders , but in fact , most psychiatric disorders .',
  'Aggression by cats towards humans is a serious behavioural , welfare and public health problem , although owners may believe it is an inevitable part of cat ownership .',
  'As with society at large , violence in psychiatric settings is a serious clinical problem .'],
 'aggression': ['A major problem with the evidence is that aggression is frequently reported only as one of the items contributing to the total score on a scale or a subscale .',
  'Crime victimisation is a serious problem in Dutch severely mentally ill outpatients .',
  'Assaultive behavior by patients is a serious problem throughout healthcare facilities .',
  'Aggression is a serious problem for both individuals and society .',
  'Physical assaults perpetrated by patients in psychiatric hospitals against mental health staff ( MHS ) is a serious concern facing psychiatric hospitals .',
  'Violence is a serious problem in psychiatric services and staff experience significant psychological reactions to being assaulted . Health and Safety Authorities in the UK and Ireland have expressed concern about violence and assault in healthcare , however , there remains a lack of clarity on matters of procedure and policy pertaining to safety and security in psychiatric hospitals .',
  'Aggressive behavior in schizophrenic patients , although infrequent , is a serious problem .',
  'Patients with recurrent pathologic aggressive behavior constitute a severe problem for psychiatric institutions .',
  'The pharmacological treatment of acute , persisting and repetitive aggression is a serious problem for other patients and staff members .',
  'Anger and anger regulation problems that result in aggressive behaviour pose a serious problem for society .',
  'Aggression is a serious medical problem that can place both the patient and the health care provider at risk .',
  'Patient aggression is a serious problem in psychiatric nursing .',
  'Violence by patients is a serious concern in psychiatric hospitals and staff are the most frequent targets of physical and verbal assault .',
  'Psychiatric patient assaults on staff are a serious problem , affecting staff , patients , and organizations .',
  'The authors examined levels of force used by officers with or without CIT training and disposition decisions in a large sample of encounters with individuals whom they suspected of having a serious mental illness , a drug or an alcohol problem , or a developmental disability .',
  '1 . Assault directed against psychiatric staff is emerging as a serious occupational health problem .',
  'The majority of referees ( n = 632 ) indicated that violence is a serious concern to both players and referees at all levels of hockey .',
  "Psychiatric boarding , defined as psychiatric patients ' waiting in hallways or other emergency room areas for inpatient beds , is a serious problem nationwide .",
  'Crime victimisation is a serious problem in psychiatric patients .',
  'Traumatic victimization , particularly sexual abuse , is a serious problem in correctional facilities and those suffering from mental illnesses are especially vulnerable .',
  'While all of these provide some rationale for eschewing aggression research , aggression remains a serious social , economic , health , and political problem .',
  'Violence against mental health service personnel is a serious workplace problem and one that appears to be increasing .',
  'Violence among psychiatric patients , while uncommon , is a serious problem mental health professionals must face .',
  'Homicide-related mental health difficulties are a serious problem worldwide , displaying high rates of lifetime incidence , high chronicity , and role impairment .',
  'The pharmacological treatment of acute , persisting and repetitive aggression is a serious problem for other patients and staff members .',
  'Violence is a serious concern in the psychiatric inpatient and emergency setting .',
  'Psychiatric patient boarding in emergency department ( ED ) is a severe and growing problem .',
  'Aggressive behaviour is a serious threat to the personal safety and property of others due to the potential that the assailant may hurt people , himself/herself or objects , and aggression has always been one of the focuses of research and concern .',
  'The nature , severity and health impact of this violence represents a serious safety concern for mental health employees .',
  'Even though this study focused only on serious incidents and defined recidivism narrowly , it found that recidivism of violence and aggression among psychiatric patients was a serious problem .',
  'Patients absconding from psychiatric hospitals pose a serious concern for the safety of patients and public alike .',
  'These findings point to violence as a serious and prevalent problem among individuals with BPD , for whom targeted violence reduction strategies that take into account ASPD and psychopathic co-morbidity must be developed .',
  'Psychiatric patient assaults on staff are a serious and continuing problem in health care settings .',
  "Research has demonstrated that psychiatric patient 's assaults on emergency services personnel providing onsite , prehospital care represent a serious and ongoing nationwide concern .",
  'Aggression continues to be a serious problem among children , especially those children who have experienced adverse life events such as maltreatment .',
  'Aggression in children and adolescents is a serious problem and is associated with various psychiatric disorders , not just conduct and oppositional defiant disorders , but in fact , most psychiatric disorders .',
  'Aggression by cats towards humans is a serious behavioural , welfare and public health problem , although owners may believe it is an inevitable part of cat ownership .',
  'As with society at large , violence in psychiatric settings is a serious clinical problem .'],
 'tumor': ['The problem with computed tomography , however , is that it can only show whether the nodes are large or not ; neither can it show the nodal architecture , nor can it detect metastases in normal-sized nodes .',
  'A major problem with flow cytometric analysis of clinical solid tumor specimens is that of non-malignant cell contamination which contributes to inaccurate results .',
  'One of the major problem with existing histological classifications is that there is no consensus on the implementation of biopsy in the treatment of HSPN .',
  'The main problem with early detection was that a background of uneven Thorotrast deposits visualized in the liver disguised the tumor as Thorotrast granulations .',
  'Even though the Wang system of classification is used by majority of reports due its clinical utility , it has a drawback of not taking into account the tumour size as done by the AJCC system .',
  'Although orthotopic animal models of cancer best reflect the disease in humans , a major drawback of these models is the inability to monitor tumor growth accurately .',
  'A possible drawback of the axial approach is increased histopathology slides .',
  'A drawback of 3D-SSFP was the inferior diagnostic confidence for bone marrow evaluation ; thus , 3D-SSFP should be combined with conventional 2D-TSE sequences .',
  'A primary drawback of these techniques is the inherent inability to accurately visualize and quantify early tumor cell invasion arising from the primary site in three dimensions .',
  'A practical drawback of this approach is the limited availability of autologous tumor samples .',
  'A drawback of the iPS cells for clinical applications is tumor formation after their',
  'High interobserver variation is a well known drawback of conventional tumor regression grading , and reaching consensus among pathologists may require a considerable effort .',
  'The high resolution of tissues on MR enterography give it a diagnostic accuracy similar to that of CT ; however , MR enterography does not have the drawback of ionizing radiation .',
  'The more frequent overstaging of small tumors within one quadrant of the rectum is a major drawback of digital examination .',
  'But a major drawback of the tumour models is the difficulty of visualizing endogenously formed tumours .',
  'A significant drawback of this approach , however , is the potential loss of important histological information , such as risk of lymph node metastasis , depth of tumor penetration , and presence of lymphatic or vascular invasion .',
  'A drawback of this technique is the potential for infusing clonogenic tumor cells with the autograft , producing relapse of the disease in the patient .',
  'The most classical and reliable technique is the surgical biopsy with prior marking using a metallic harpoon , but , besides its high cost , it has the drawback of being an aggressive technique for the diagnosis of a benign pathology .',
  'In addition , the risk of tumor formation due to residual undifferentiated cells is a serious unresolved problem .',
  'A serious problem for every pathologist is how to avoid making errors in histopathological diagnosis .',
  'The presence of excessive heterogeneity among and within sublines poses a serious problem for experimental oncologists using these sublines in their tumor models .',
  'The lack of definitive criteria for distinguishing metastatic from benign nodes is a serious shortcoming of current imaging options .',
  'Although quantitation of FDG uptake using SUV shows significantly higher tracer concentrations for malignant than benign lesions , the wide overlap of individual SUVs between these two groups is a serious concern in diagnostic evaluation .',
  'They emphasise the fact that such lesions , though usually not constituting a serious clinical or diagnostic problem , as a simple sonographic follow-up will suffice to clarify the situation , may nevertheless , in certain particular clinical situations such as in the course of tumour staging of the digestive apparatus , require full diagnostic investigation using all the techniques available ( ultrasonic tomography , CAT , liver arteriography , sonographically guided thin-needle biopsy .',
  'The increase in tumor markers with negative or equivocal conventional imaging modalities represents a serious dilemma in the follow-up of previously treated cancer patients .',
  'CT scans of these tumours make a serious problem with proper targeting and tissue sampling from proper sites .',
  'Admixture of normal and neoplastic cells is a serious problem in the evaluation of tumor cell kinetic parameters by flow cytometry , in particular for DNA diploid tumors .'],
 'ldl': ['A major problem with the focus on low fat is that high-carbohydrate diets can contribute to increasing triglyceride and decreasing high-density lipoprotein ( HDL ) concentrations .',
  'Another area of development is that of acyl coenzyme A cholesterol acyltransferase inhibitors , i.e. , drugs interfering with cholesterol esterification in tissues , particularly in the arterial wall ; the major problem with these seems to be that of poor tolerability and of lack of definitive proof of plasma cholesterol reduction in humans .',
  'A drawback of this method is the necessity of LDL isolation before chromatography .',
  'Statin adherence is a serious problem in patients with hyperlipidemia .',
  'Dyslipidaemia is becoming a serious health problem in the developing world also , even among the apparently healthy , and necessitates periodic lipid profile screening .',
  '8-oxodeoxyguanine ( oxidatively modified DNA ) and oxidized low-density lipoproteins ( LDL ) occur in SLE , a disease in which premature atherosclerosis is a serious problem .',
  'Dyslipidemia constitutes a serious health problem that should be diagnosed and treated by the family physician .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'The hyperlipidemia is a serious health problem that increases the risk of many complications including cardiovascular disease .',
  'Dyslipidemia was a serious public health problem in the studied population , especially among women and the elderly .',
  'Our results thus reveal a serious limitation to the reproducibility of current lipid profiling experiments and reveal challenges to the integration of such data from different laboratories .',
  'Dyslipidemia has become a serious health problem in children and adolescents worldwide for its high prevalence .',
  'Hypercholesterolemia represents a serious public health problem as it significantly increases the risk of developing cardiovascular diseases .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'Abnormal lipid levels contribute significantly to the risk of coronary heart disease , a major cardiovascular disease and a serious health problem .',
  'The management of hyperlipidemia in individuals aged 60 or over is a serious problem , given the frequency of metabolic abnormalities in this age group .',
  'High blood low-density-lipoprotein ( LDL ) cholesterol is a serious health problem among an increased number of patients in the Western world .',
  'Chylomicronemia caused by a deficiency in lipoprotein lipase ( LPL ) or GPIHBP1 ( the endothelial cell protein that transports LPL to the capillary lumen ) is typically diagnosed during childhood and represents a serious , lifelong medical problem .',
  'Dyslipidemia is the primary cause of cardiovascular disease , which is a serious human health problem in large parts of the world .',
  'Hypertriglyceridemia has become a serious public health problem .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'Oxidatively modified DNA ( 8-oxodeoxyguanine ) and low-density lipoproteins ( LDL ) occur in SLE , a disease in which premature atherosclerosis is a serious problem .'],
 'cholesterol': ['A major problem with the focus on low fat is that high-carbohydrate diets can contribute to increasing triglyceride and decreasing high-density lipoprotein ( HDL ) concentrations .',
  'Another area of development is that of acyl coenzyme A cholesterol acyltransferase inhibitors , i.e. , drugs interfering with cholesterol esterification in tissues , particularly in the arterial wall ; the major problem with these seems to be that of poor tolerability and of lack of definitive proof of plasma cholesterol reduction in humans .',
  'A drawback of this method is the necessity of LDL isolation before chromatography .',
  'Statin adherence is a serious problem in patients with hyperlipidemia .',
  'Dyslipidaemia is becoming a serious health problem in the developing world also , even among the apparently healthy , and necessitates periodic lipid profile screening .',
  '8-oxodeoxyguanine ( oxidatively modified DNA ) and oxidized low-density lipoproteins ( LDL ) occur in SLE , a disease in which premature atherosclerosis is a serious problem .',
  'Dyslipidemia constitutes a serious health problem that should be diagnosed and treated by the family physician .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'The hyperlipidemia is a serious health problem that increases the risk of many complications including cardiovascular disease .',
  'Dyslipidemia was a serious public health problem in the studied population , especially among women and the elderly .',
  'Our results thus reveal a serious limitation to the reproducibility of current lipid profiling experiments and reveal challenges to the integration of such data from different laboratories .',
  'Dyslipidemia has become a serious health problem in children and adolescents worldwide for its high prevalence .',
  'Hypercholesterolemia represents a serious public health problem as it significantly increases the risk of developing cardiovascular diseases .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'Abnormal lipid levels contribute significantly to the risk of coronary heart disease , a major cardiovascular disease and a serious health problem .',
  'The management of hyperlipidemia in individuals aged 60 or over is a serious problem , given the frequency of metabolic abnormalities in this age group .',
  'High blood low-density-lipoprotein ( LDL ) cholesterol is a serious health problem among an increased number of patients in the Western world .',
  'Chylomicronemia caused by a deficiency in lipoprotein lipase ( LPL ) or GPIHBP1 ( the endothelial cell protein that transports LPL to the capillary lumen ) is typically diagnosed during childhood and represents a serious , lifelong medical problem .',
  'Dyslipidemia is the primary cause of cardiovascular disease , which is a serious human health problem in large parts of the world .',
  'Hypertriglyceridemia has become a serious public health problem .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'Oxidatively modified DNA ( 8-oxodeoxyguanine ) and low-density lipoproteins ( LDL ) occur in SLE , a disease in which premature atherosclerosis is a serious problem .'],
 'hypercholesterolemia': ['A major problem with the focus on low fat is that high-carbohydrate diets can contribute to increasing triglyceride and decreasing high-density lipoprotein ( HDL ) concentrations .',
  'Another area of development is that of acyl coenzyme A cholesterol acyltransferase inhibitors , i.e. , drugs interfering with cholesterol esterification in tissues , particularly in the arterial wall ; the major problem with these seems to be that of poor tolerability and of lack of definitive proof of plasma cholesterol reduction in humans .',
  'A drawback of this method is the necessity of LDL isolation before chromatography .',
  'Statin adherence is a serious problem in patients with hyperlipidemia .',
  'Dyslipidaemia is becoming a serious health problem in the developing world also , even among the apparently healthy , and necessitates periodic lipid profile screening .',
  '8-oxodeoxyguanine ( oxidatively modified DNA ) and oxidized low-density lipoproteins ( LDL ) occur in SLE , a disease in which premature atherosclerosis is a serious problem .',
  'Dyslipidemia constitutes a serious health problem that should be diagnosed and treated by the family physician .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'The hyperlipidemia is a serious health problem that increases the risk of many complications including cardiovascular disease .',
  'Dyslipidemia was a serious public health problem in the studied population , especially among women and the elderly .',
  'Our results thus reveal a serious limitation to the reproducibility of current lipid profiling experiments and reveal challenges to the integration of such data from different laboratories .',
  'Dyslipidemia has become a serious health problem in children and adolescents worldwide for its high prevalence .',
  'Hypercholesterolemia represents a serious public health problem as it significantly increases the risk of developing cardiovascular diseases .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'Abnormal lipid levels contribute significantly to the risk of coronary heart disease , a major cardiovascular disease and a serious health problem .',
  'The management of hyperlipidemia in individuals aged 60 or over is a serious problem , given the frequency of metabolic abnormalities in this age group .',
  'High blood low-density-lipoprotein ( LDL ) cholesterol is a serious health problem among an increased number of patients in the Western world .',
  'Chylomicronemia caused by a deficiency in lipoprotein lipase ( LPL ) or GPIHBP1 ( the endothelial cell protein that transports LPL to the capillary lumen ) is typically diagnosed during childhood and represents a serious , lifelong medical problem .',
  'Dyslipidemia is the primary cause of cardiovascular disease , which is a serious human health problem in large parts of the world .',
  'Hypertriglyceridemia has become a serious public health problem .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'Oxidatively modified DNA ( 8-oxodeoxyguanine ) and low-density lipoproteins ( LDL ) occur in SLE , a disease in which premature atherosclerosis is a serious problem .'],
 'lipoprotein': ['A major problem with the focus on low fat is that high-carbohydrate diets can contribute to increasing triglyceride and decreasing high-density lipoprotein ( HDL ) concentrations .',
  'Another area of development is that of acyl coenzyme A cholesterol acyltransferase inhibitors , i.e. , drugs interfering with cholesterol esterification in tissues , particularly in the arterial wall ; the major problem with these seems to be that of poor tolerability and of lack of definitive proof of plasma cholesterol reduction in humans .',
  'A drawback of this method is the necessity of LDL isolation before chromatography .',
  'Statin adherence is a serious problem in patients with hyperlipidemia .',
  'Dyslipidaemia is becoming a serious health problem in the developing world also , even among the apparently healthy , and necessitates periodic lipid profile screening .',
  '8-oxodeoxyguanine ( oxidatively modified DNA ) and oxidized low-density lipoproteins ( LDL ) occur in SLE , a disease in which premature atherosclerosis is a serious problem .',
  'Dyslipidemia constitutes a serious health problem that should be diagnosed and treated by the family physician .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'The hyperlipidemia is a serious health problem that increases the risk of many complications including cardiovascular disease .',
  'Dyslipidemia was a serious public health problem in the studied population , especially among women and the elderly .',
  'Our results thus reveal a serious limitation to the reproducibility of current lipid profiling experiments and reveal challenges to the integration of such data from different laboratories .',
  'Dyslipidemia has become a serious health problem in children and adolescents worldwide for its high prevalence .',
  'Hypercholesterolemia represents a serious public health problem as it significantly increases the risk of developing cardiovascular diseases .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'Abnormal lipid levels contribute significantly to the risk of coronary heart disease , a major cardiovascular disease and a serious health problem .',
  'The management of hyperlipidemia in individuals aged 60 or over is a serious problem , given the frequency of metabolic abnormalities in this age group .',
  'High blood low-density-lipoprotein ( LDL ) cholesterol is a serious health problem among an increased number of patients in the Western world .',
  'Chylomicronemia caused by a deficiency in lipoprotein lipase ( LPL ) or GPIHBP1 ( the endothelial cell protein that transports LPL to the capillary lumen ) is typically diagnosed during childhood and represents a serious , lifelong medical problem .',
  'Dyslipidemia is the primary cause of cardiovascular disease , which is a serious human health problem in large parts of the world .',
  'Hypertriglyceridemia has become a serious public health problem .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'Oxidatively modified DNA ( 8-oxodeoxyguanine ) and low-density lipoproteins ( LDL ) occur in SLE , a disease in which premature atherosclerosis is a serious problem .'],
 'dyslipidemia': ['A major problem with the focus on low fat is that high-carbohydrate diets can contribute to increasing triglyceride and decreasing high-density lipoprotein ( HDL ) concentrations .',
  'Another area of development is that of acyl coenzyme A cholesterol acyltransferase inhibitors , i.e. , drugs interfering with cholesterol esterification in tissues , particularly in the arterial wall ; the major problem with these seems to be that of poor tolerability and of lack of definitive proof of plasma cholesterol reduction in humans .',
  'A drawback of this method is the necessity of LDL isolation before chromatography .',
  'Statin adherence is a serious problem in patients with hyperlipidemia .',
  'Dyslipidaemia is becoming a serious health problem in the developing world also , even among the apparently healthy , and necessitates periodic lipid profile screening .',
  '8-oxodeoxyguanine ( oxidatively modified DNA ) and oxidized low-density lipoproteins ( LDL ) occur in SLE , a disease in which premature atherosclerosis is a serious problem .',
  'Dyslipidemia constitutes a serious health problem that should be diagnosed and treated by the family physician .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'The hyperlipidemia is a serious health problem that increases the risk of many complications including cardiovascular disease .',
  'Dyslipidemia was a serious public health problem in the studied population , especially among women and the elderly .',
  'Our results thus reveal a serious limitation to the reproducibility of current lipid profiling experiments and reveal challenges to the integration of such data from different laboratories .',
  'Dyslipidemia has become a serious health problem in children and adolescents worldwide for its high prevalence .',
  'Hypercholesterolemia represents a serious public health problem as it significantly increases the risk of developing cardiovascular diseases .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'Abnormal lipid levels contribute significantly to the risk of coronary heart disease , a major cardiovascular disease and a serious health problem .',
  'The management of hyperlipidemia in individuals aged 60 or over is a serious problem , given the frequency of metabolic abnormalities in this age group .',
  'High blood low-density-lipoprotein ( LDL ) cholesterol is a serious health problem among an increased number of patients in the Western world .',
  'Chylomicronemia caused by a deficiency in lipoprotein lipase ( LPL ) or GPIHBP1 ( the endothelial cell protein that transports LPL to the capillary lumen ) is typically diagnosed during childhood and represents a serious , lifelong medical problem .',
  'Dyslipidemia is the primary cause of cardiovascular disease , which is a serious human health problem in large parts of the world .',
  'Hypertriglyceridemia has become a serious public health problem .',
  'Despite the obvious heterogeneity and a certain paucity of studies , we found consistent results concerning the prevalence of hypercholesterolemia in Portugal , and we can state that this constitutes a serious health problem in our country .',
  'Oxidatively modified DNA ( 8-oxodeoxyguanine ) and low-density lipoproteins ( LDL ) occur in SLE , a disease in which premature atherosclerosis is a serious problem .'],
 'cocaine': ['One problem with LVM is that it is producing life-threatening neutropenia in an alarming number of cocaine abusers .',
  'Crack use is considered a serious public health problem in Brazil , and there are few solution strategies .',
  'Cocaine abuse remains a devastating medical problem for our society .',
  'International smuggling of cocaine by internal concealment is a serious and growing problem .',
  'Levamisole-contaminated cocaine toxicity is a serious emerging public health concern , and providers should be aware of its presentation and management .',
  'Cocaine use remains a serious problem , despite intensive efforts to curb abuse .',
  'Crack use has become a severe health problem in Brazil .',
  'Cocaine abuse is a serious and socially damaging illegal drug problem .',
  'Cocaine abuse continues to be a serious health problem worldwide .',
  'Cocaine abuse is a serious social problem that precipitates a significant number of emergency hospital encounters .',
  'Although cocaine addiction remains a serious health and societal problem in the United States , no FDA-approved treatment has been developed .',
  'Although crack cocaine does not yet constitute a major drug problem in the Nordic countries , heed should be paid to North America where crack cocaine has developed into a serious and widespread problem only a few years after its introduction .',
  'Cocaine use disorder ( CUD ) remains a debilitating health problem in the United States for which there are no Food and Drug Administration-approved treatment options .',
  'Cocaine use continues to be a serious worldwide public health problem .',
  'Crack cocaine dependence has become a severe public health problem in Brazil , and current psychosocial approaches to this problem have shown little or no effectiveness .',
  'Crack cocaine ( crack ) dependence is a severe disorder associated with considerable morbidity and mortality , constituting a major public health problem in Brazil .',
  'The high prevalence of cocaine use \xa0 continues to be a serious public health concern .',
  'Chronic cocaine abuse remains a serious and costly public health problem .',
  'Soon thereafter , it became apparent that crack cocaine abuse was a serious and important public health concern .',
  'The high consumption of crack has become a serious public health problem .',
  'Cocaine abuse continues to be a serious health problem worldwide .',
  'The high prevalence of levamisole-adulterated cocaine and potential toxicity in cocaine users is a serious public health concern .',
  'Cocaine represents a serious problem to society .',
  'This is a serious public health problem because cocaine is highly addictive and is associated with a variety of serious complications .',
  'Cocaine abuse is a serious health problem in many areas of the world , yet there are no proven effective medications for the treatment of cocaine dependence .'],
 'crack': ['One problem with LVM is that it is producing life-threatening neutropenia in an alarming number of cocaine abusers .',
  'Crack use is considered a serious public health problem in Brazil , and there are few solution strategies .',
  'Cocaine abuse remains a devastating medical problem for our society .',
  'International smuggling of cocaine by internal concealment is a serious and growing problem .',
  'Levamisole-contaminated cocaine toxicity is a serious emerging public health concern , and providers should be aware of its presentation and management .',
  'Cocaine use remains a serious problem , despite intensive efforts to curb abuse .',
  'Crack use has become a severe health problem in Brazil .',
  'Cocaine abuse is a serious and socially damaging illegal drug problem .',
  'Cocaine abuse continues to be a serious health problem worldwide .',
  'Cocaine abuse is a serious social problem that precipitates a significant number of emergency hospital encounters .',
  'Although cocaine addiction remains a serious health and societal problem in the United States , no FDA-approved treatment has been developed .',
  'Although crack cocaine does not yet constitute a major drug problem in the Nordic countries , heed should be paid to North America where crack cocaine has developed into a serious and widespread problem only a few years after its introduction .',
  'Cocaine use disorder ( CUD ) remains a debilitating health problem in the United States for which there are no Food and Drug Administration-approved treatment options .',
  'Cocaine use continues to be a serious worldwide public health problem .',
  'Crack cocaine dependence has become a severe public health problem in Brazil , and current psychosocial approaches to this problem have shown little or no effectiveness .',
  'Crack cocaine ( crack ) dependence is a severe disorder associated with considerable morbidity and mortality , constituting a major public health problem in Brazil .',
  'The high prevalence of cocaine use \xa0 continues to be a serious public health concern .',
  'Chronic cocaine abuse remains a serious and costly public health problem .',
  'Soon thereafter , it became apparent that crack cocaine abuse was a serious and important public health concern .',
  'The high consumption of crack has become a serious public health problem .',
  'Cocaine abuse continues to be a serious health problem worldwide .',
  'The high prevalence of levamisole-adulterated cocaine and potential toxicity in cocaine users is a serious public health concern .',
  'Cocaine represents a serious problem to society .',
  'This is a serious public health problem because cocaine is highly addictive and is associated with a variety of serious complications .',
  'Cocaine abuse is a serious health problem in many areas of the world , yet there are no proven effective medications for the treatment of cocaine dependence .'],
 'burns': ['The problem with wood is that it is a fire-prone material .',
  'Burn scars remain a serious psychological and physiological problem for affected people .',
  'Although patients frequently experience sleep disturbances and nightmares in the first weeks after a severe burn , information is scarce on the course and prevention of this problem .',
  'Burn infection is a serious problem that delays wound healing and leads to death .',
  'The treatment of burns of various depth and location which are combined with thermoinhalation affections of the respiratory organs is a serious problem during the entire course of burn disease .',
  'Electrical injury is a serious public health problem .',
  'Burn injuries are a serious public health problem .',
  'Concomitant smoke inhalation trauma in burn patients is a serious medical problem .',
  'A serious problem in emergency medicine is the correct evaluation of skin burn depth to make the appropriate choice of treatment .',
  'Scars are a serious health concern for burn victims and individuals with skin conditions associated with wound healing .',
  'Burn scars are a serious psychological and physiological problem for affected individuals .',
  'Burns are a serious health problem leading to several thousand deaths annually , and despite the growth of science and technology , automated burns diagnosis still remains a major challenge .',
  'High-voltage electrocution injuries are a serious problem with potential for both immediate and delayed neurologic sequelae .',
  'High-voltage electrocution injuries are a serious problem with potential for both immediate and delayed neurologic sequelae .',
  'Child firesetting constitutes a serious and widespread problem , yet little definitive evidence exists distinguishing child firesetters from their nonfiresetting peers .',
  'According to WHO , burns are a serious public health problem and the second most common cause for injury in rural Nepal , accounting for 5 % of disabilities .',
  'Despite the fact that advances of burn treatment have led to reduction in the morbidity caused by burns , burn infection is still a serious problem .',
  'As a serious yet preventable problem , scald injuries in children have been a priority for prevention in Australia and other developed countries .',
  'Severe deformities of the ears are a distressing problem after burn injury .',
  'Electrical burns are a serious problem within burn medicine even though they are relatively uncommon .',
  'Sandal burn injuries are a serious health problem .',
  'Burns are a devastating public health problem that result in 10 million disability-adjusted life-years lost in low- and middle-income countries .',
  'Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns .',
  'Electrical burn injuries continue to be a serious problem of modern society .',
  'Car fires are a deadly postcrash problem .',
  'Occupational burns have been determined to be a serious public health concern .',
  'Fire and burn-related injuries are a leading cause of morbidity and mortality worldwide , and is a serious public health problem in developing countries .',
  'Burn-related injuries are a serious problem for individuals < or=20 years of age and are potentially preventable .',
  'Introduction Burns are a serious public health problem globally , causing an estimated 265,000 deaths per year .',
  'Injuries and deaths from burns are a serious , yet preventable health problem globally .',
  "Exposure to electrical current via industrial or residential accidents or lightning strikes is a serious and growing concern in today 's medical community .",
  'Burns are a serious public health problem among paediatrics .',
  'Although rare , head burns involving the calvarium are a serious complication of burns and electrical injury , and present therapeutic challenges to the surgical burn care team .',
  'Fires caused by cigarettes through the ignition of upholstered furniture and mattresses are a serious public health problem , accounting for more than 1500 deaths and 7000 serious injuries per year in the United States .',
  'One child had a severe electrical injury and posed a difficult management problem .',
  'High-voltage electrocution injuries are a serious problem with potential for immediate , delayed , and long-term neurologic sequelae .',
  'Burn scars remain a serious physical and psychological problem for the affected people .',
  'Burn injuries are a devastating critical care problem .',
  'Burns are a serious public health problem worldwide accounting for an estimated 265,000 deaths annually from fires alone .',
  'Fire-related mortality among Aboriginal people in BC is a preventable public health concern .',
  'Danger from OR fires still a serious problem . ASA Panel reports risks .',
  'Smoke inhalation in burn patients is a serious medical problem around the world .',
  'Electrocution is a serious public health concern and reported worldwide with few fatal ending .',
  'Immediately following injury , burn shock represents a life-threatening problem .',
  'Full thickness burns of the chest in childhood are a devastating problem that requires challenging reconstructive options .',
  'Burn injuries are a serious problem worldwide , with most occurrences in low- and middle-income countries .',
  'IED attacks pose a serious medical problem , considering their high number and the severity of injuries they cause .',
  'Occupational exposure to welding fumes is a serious occupational health problem all over the world .',
  'Although there generally is ready access to appropriate care and short transport times , burn injury remains a serious concern .',
  'Consequently we can conclude that in Lithuania as well as all over the world burns are considered to be a serious medical , psychological , economic and social problem .',
  'Burn scars remain a serious physical and psychological problem for the affected .',
  'Burns of the head and neck with or without respiratory tract injury remain a serious and complex problem .',
  'Occupational exposure to welding fumes is a serious occupational health problem all over the world .',
  'Abusive inhalation of butane gas is becoming a serious public health problem among teenagers and young adult population ; however , there has been little reporting on explosion burns associated with abuse of butane cigarette lighter fluid .',
  'Damage to the nervous system can be a serious problem for patients struck by lightning .',
  'Self-inflicted burns have been considered a serious mental health problem throughout the world and especially in economically developing countries .',
  'Infection of burn wounds is a serious problem because it can delay healing , increase scarring and invasive infection may result in the death of the patient .',
  'Burns represent a serious problem around the world especially in low- and middle-income countries .',
  'Burn injuries are a serious global public health concern with significant worldwide mortality and morbidity rates .',
  'The fire is a tragic demonstration of shortcomings in hazardous material management and emergency response .'],
 'physician': ['A problem with the current law is that doctors who follow current best practice can not be confident that they will be protected from criminal prosecution .',
  'A problem with this approach , however , is that the labor components of the typical health care provider are no longer atypical .',
  'The problem with this avoidance position is that sensitive issues such as sexuality , drug use , and death and dying are laden with spiritual implications , particularly when students are asked to make personal decisions regarding these issues .',
  'While individual accountability is a serious problem for health care providers , corporate liability is a major problem for the institution .',
  'The number of negligence claims against physicians and health institutes is increasing and has become a serious financial problem .',
  'STN-DBS is not morally neutral and the case involves a tragic dilemma : a conflict between irreconcilable duties for the physician .',
  '[ A serious medical morality problem ] .',
  'This fact , far from being an advantage , turns into a serious problem when nursing staff has to choose the most adequate for each case .',
  'In particular , the question of " whose agent ( physician ) are you ? " when a family is in conflict often creates a serious ethical dilemma for the family physician .',
  'At present , the increasing trend of medical disputes has become a serious problem in the work of medical institutions , and directly affects the social stability and orderly development of the institutions .',
  'The conflicts that arise when minors or their legal representatives refuse to receive medical treatment considered necessary by the paediatrician pose a serious ethical dilemma and also have a considerable emotional impact .'],
 'conflict': ['A problem with the current law is that doctors who follow current best practice can not be confident that they will be protected from criminal prosecution .',
  'A problem with this approach , however , is that the labor components of the typical health care provider are no longer atypical .',
  'The problem with this avoidance position is that sensitive issues such as sexuality , drug use , and death and dying are laden with spiritual implications , particularly when students are asked to make personal decisions regarding these issues .',
  'While individual accountability is a serious problem for health care providers , corporate liability is a major problem for the institution .',
  'The number of negligence claims against physicians and health institutes is increasing and has become a serious financial problem .',
  'STN-DBS is not morally neutral and the case involves a tragic dilemma : a conflict between irreconcilable duties for the physician .',
  '[ A serious medical morality problem ] .',
  'This fact , far from being an advantage , turns into a serious problem when nursing staff has to choose the most adequate for each case .',
  'In particular , the question of " whose agent ( physician ) are you ? " when a family is in conflict often creates a serious ethical dilemma for the family physician .',
  'At present , the increasing trend of medical disputes has become a serious problem in the work of medical institutions , and directly affects the social stability and orderly development of the institutions .',
  'The conflicts that arise when minors or their legal representatives refuse to receive medical treatment considered necessary by the paediatrician pose a serious ethical dilemma and also have a considerable emotional impact .'],
 'waste': ['An important problem with the process is that they do not take necessary precautionary measures before handling e-waste .',
  'The generation of liquid crystal display waste is becoming a serious social problem .',
  'These wastes cause a serious disposable problem with the environment .',
  '( First Nations is the term commonly used in Canada to describe the various societies of indigenous peoples who are accorded status as " Indians " by the Indian Act of 1985 and who are not of Inuit or Métis descent . ) Along with a lack of adequate funding to address human and environmental issues-as well as past industrial exploitation of First Nations lands-the safety and acceptability of many solid waste management practices in Canadian First Nations communities have become a serious concern for many members from both human and environmental health perspectives .',
  'With the development of science and technology , solid waste management has become a serious environmental problem for most communities all over the world .',
  'Municipal solid waste ( MSW ) management is a serious problem for public administrations , especially in terms of treatment and final disposal .',
  'It is important to visualize an alternative and profitable use of this waste , as it constitutes a serious environmental problem .',
  'The rapid growing CFRP market raises a serious concern of the waste management .',
  'Exposure to waste is a serious health concern in Beitbridge .',
  'Meanwhile , a serious problem of environmental sustainable development caused by the production and utilization of paper has been resulted to modern society .',
  'Thus , the management system of solid waste is very poor and has become a serious problem .',
  'Hazardous waste disposal is a serious environmental concern in China .',
  'This species has not only caused considerable concern among public health officials but also highlighted that the growing accumulations of used tires are a serious solid waste problem and a challenge to the recycling industry .',
  'Solid waste is a serious and growing problem thoughout tropical Asia .',
  'Wastes have been considered to be a serious worldwide environmental problem in recent years .',
  'A mass of construction and demolition ( C&D ) waste are generated in Shanghai every year , and it has become a serious environment problem .',
  'Littered waste is a severe environmental problem .',
  'The shortage of natural aggregates has recently emerged as a serious problem owing to the tremendous growth of the concrete industry .',
  'Improper healthcare waste management ( HCWM ) poses a serious public health problem worldwide .',
  'Infectious hospital waste disposal a troublesome , costly problem .',
  'Currently , villages " besieged with garbage " have become a serious problem in rural areas of China .',
  'Hospital wastes pose a serious problem .',
  'Waste glass creates a serious environmental problem , mainly because of the inconsistency of the waste glass streams .',
  'Inorganic urban solid waste ( IUSW ) is a serious problem in developing countries , and IUSW in the street that does not have adequate final disposal is responsible for serious environmental effects .',
  'Countries face a serious problem due to the generation and management of higher volumes of waste .',
  'The disposal of industrial wastes has been recognized as a serious problem long before the ecological movement gained its present strength .',
  'Construction waste is a serious problem that should be addressed to protect environment and save resources , some of which have a high recovery value .',
  'Hospital wastes pose a serious public health problem .',
  'The aim of this study is to define a multi-criteria , web-based approach that can be used to manage the illegal dumping of solid waste , which is a serious environmental concern both in developing and developed countries .',
  'These laboratories produce solid and liquid biomedical waste ( BMW ) that constitutes a serious health problem for humans and their environment .',
  'The combined contamination of brominated flame retardants ( BFRs ) and heavy metals in electronic waste ( e-waste ) recycling and disposal areas has been a serious concern owing to their environmental persistence and chronic toxicities .',
  'We wanted to tackle the shortage of land for waste disposal that is a serious and growing problem in most large urban regions .',
  'Solid waste management is one of the most challenging issues in urban cities , which are facing a serious pollution problem due to the generation of huge quantities of solid waste .',
  'The disposal of household hazardous waste and materials as municipal solid waste ( MSW ) remains a vexing problem for solid waste managers and policymakers .',
  'Principles thereby are : Avoidance of waste , prevention of problematic substances , reduction of waste , utilization of waste and disposal of waste . As soon as we are in the position to put these principles into practice , is waste no longer a threatening problem for us and our environment .',
  'Their disposal poses a serious environmental pollution problem .',
  'The amount of the related wastes is estimated at up to 50,000 tons per year , representing a serious disposal problem with a consequent negative impact on the environment .',
  'Municipal solid waste ( MSW ) piling up is becoming a serious problem in all developing countries ( DC ) as a result of inequitable waste collection and treatment .',
  'The solid residues ( pulp , husk and parchment ) represent a serious environmental problem and do not have an adequate disposal mechanism .',
  'These waste materials in large quantities can create a serious environmental problem .',
  'The enormous amount of Ulva biomass thus becomes a troublesome waste disposal problem .',
  'The disposal of solid waste is a serious problem worldwide that is made worse in developing countries due to inadequate planning and unsustainable solid waste management .',
  'The enormous quantities of municipal solid waste ( MSW ) generation in Indian cities has emerged as a serious concern .',
  'The disposal of construction and demolition ( C&D ) waste has become a serious problem in China due to the rapid increase of Chinese construction industry in recent years .',
  'Management of household solid waste and agro industrial residues generated from various sources is a serious problem due to huge ever increasing population and pollution .',
  'Household solid waste management is a severe problem in big cities of developing countries . Mismanaged solid waste dumpsites produce bad sanitary , ecological and economic consequences for the whole population , especially for the poorest urban inhabitants .',
  'This , together with the fact that in many European countries the rate of recycling and reuse of C&DW is still quite low has engendered a serious environmental problem and a motivation to develop strategies and management plans to solve it .'],
 'disposal': ['An important problem with the process is that they do not take necessary precautionary measures before handling e-waste .',
  'Further improvements can only be applied by a chemical precipitation , with the drawback of increasing the wastewater disposal cost up to 6.5 \xa0 euros \xa0 CAP',
  'The accumulation of BPC in the SMBR sludge mixture would facilitate the formation of a sludge fouling layer on the membrane surface , thus causing a serious fouling problem .',
  'The huge volume of sludge emanating from the tannery effluent treatment plants poses a serious environmental problem .',
  'The generation of liquid crystal display waste is becoming a serious social problem .',
  'Organic wastes , such as the organic fractions of municipal solid waste ( OFMSW ) or sewage sludge ( SS ) , have become a serious environmental problem in Russia as well as in other countries .',
  'Massively produced sewage sludge brings a serious problem to environment .',
  'These wastes cause a serious disposable problem with the environment .',
  'Sea sludge , which is sediment of fish excrement and sewage on the sea bottom , continues to be a serious environmental problem .',
  '( First Nations is the term commonly used in Canada to describe the various societies of indigenous peoples who are accorded status as " Indians " by the Indian Act of 1985 and who are not of Inuit or Métis descent . ) Along with a lack of adequate funding to address human and environmental issues-as well as past industrial exploitation of First Nations lands-the safety and acceptability of many solid waste management practices in Canadian First Nations communities have become a serious concern for many members from both human and environmental health perspectives .',
  'Molasses is a wildly used feedstock for fermentation , but it also poses a severe wastewater-disposal problem worldwide .',
  'With the development of science and technology , solid waste management has become a serious environmental problem for most communities all over the world .',
  'Phytoremediation technologies generate huge quantities of biomass , the disposal of which is a serious concern .',
  'Municipal solid waste ( MSW ) management is a serious problem for public administrations , especially in terms of treatment and final disposal .',
  'It is important to visualize an alternative and profitable use of this waste , as it constitutes a serious environmental problem .',
  'The rapid growing CFRP market raises a serious concern of the waste management .',
  'Exposure to waste is a serious health concern in Beitbridge .',
  'Meanwhile , a serious problem of environmental sustainable development caused by the production and utilization of paper has been resulted to modern society .',
  'Sago industries effluent containing large amounts of organic content produced excess sludge which is a serious problem in wastewater treatment .',
  'Disposal of tons of sludge produced daily by sewage treatment plants in large cities is a serious problem .',
  'Thus , the management system of solid waste is very poor and has become a serious problem .',
  'Hazardous waste disposal is a serious environmental concern in China .',
  'The excessive growth of filamentous bacteria and the resultant bulking of activated sludge constitute a serious problem in numerous wastewater treatment plants .',
  'This species has not only caused considerable concern among public health officials but also highlighted that the growing accumulations of used tires are a serious solid waste problem and a challenge to the recycling industry .',
  'Solid waste is a serious and growing problem thoughout tropical Asia .',
  'Wastes have been considered to be a serious worldwide environmental problem in recent years .',
  'A mass of construction and demolition ( C&D ) waste are generated in Shanghai every year , and it has become a serious environment problem .',
  'Littered waste is a severe environmental problem .',
  'The shortage of natural aggregates has recently emerged as a serious problem owing to the tremendous growth of the concrete industry .',
  'Even though treated effluent water from wastewater treatment plants are utilized for irrigation , disposal of sewage sludge is becoming a serious problem .',
  'Improper healthcare waste management ( HCWM ) poses a serious public health problem worldwide .',
  'Infectious hospital waste disposal a troublesome , costly problem .',
  'Currently , villages " besieged with garbage " have become a serious problem in rural areas of China .',
  'Hospital wastes pose a serious problem .',
  'Waste glass creates a serious environmental problem , mainly because of the inconsistency of the waste glass streams .',
  'Sewage sludge is a serious problem facing modern wastewater treatment plants .',
  'This review aims to provide a critical overview regarding the deactivation of sludge-associated pathogens by AD , through which a serious concern on the effectiveness and rationality of AD towards sludge pathogens control was raised .',
  'Inorganic urban solid waste ( IUSW ) is a serious problem in developing countries , and IUSW in the street that does not have adequate final disposal is responsible for serious environmental effects .',
  'Countries face a serious problem due to the generation and management of higher volumes of waste .',
  'The disposal of industrial wastes has been recognized as a serious problem long before the ecological movement gained its present strength .',
  'Construction waste is a serious problem that should be addressed to protect environment and save resources , some of which have a high recovery value .',
  'With increasing construction of wastewater treatment plants and stricter policies , municipal sewage sludge ( MSS ) disposal has become a serious problem .',
  'The calcification of Anaerobic Granular Sludge is a serious problem in the application of anaerobic methanization biotechnology .',
  'Hospital wastes pose a serious public health problem .',
  'The aim of this study is to define a multi-criteria , web-based approach that can be used to manage the illegal dumping of solid waste , which is a serious environmental concern both in developing and developed countries .',
  'These laboratories produce solid and liquid biomedical waste ( BMW ) that constitutes a serious health problem for humans and their environment .',
  'The combined contamination of brominated flame retardants ( BFRs ) and heavy metals in electronic waste ( e-waste ) recycling and disposal areas has been a serious concern owing to their environmental persistence and chronic toxicities .',
  'Ultimate disposal of the sludge or the adsorbate , however , is a serious problem .',
  'We wanted to tackle the shortage of land for waste disposal that is a serious and growing problem in most large urban regions .',
  'Solid waste management is one of the most challenging issues in urban cities , which are facing a serious pollution problem due to the generation of huge quantities of solid waste .',
  'Therefore , this by-product of activated sludge process ( ASP ) presents a serious environmental problem .',
  'The disposal of household hazardous waste and materials as municipal solid waste ( MSW ) remains a vexing problem for solid waste managers and policymakers .',
  'Principles thereby are : Avoidance of waste , prevention of problematic substances , reduction of waste , utilization of waste and disposal of waste . As soon as we are in the position to put these principles into practice , is waste no longer a threatening problem for us and our environment .',
  'Their disposal poses a serious environmental pollution problem .',
  'As a result of the wide application and utilization of the waste activated sludge process , excess sludge presents a serious disposal problem .',
  'Paper mill sludges are produced in large amounts and their disposal is a serious environmental problem .',
  'The amount of the related wastes is estimated at up to 50,000 tons per year , representing a serious disposal problem with a consequent negative impact on the environment .',
  'Municipal solid waste ( MSW ) piling up is becoming a serious problem in all developing countries ( DC ) as a result of inequitable waste collection and treatment .',
  'The disposal of excess sludge from wastewater treatment plants is a serious problem that needs to be addressed .',
  'The solid residues ( pulp , husk and parchment ) represent a serious environmental problem and do not have an adequate disposal mechanism .',
  'Excess sludge production from wastewater treatment plants has significantly increased , and sludge disposal has become a serious social and environmental problem .',
  'Million tons of sewage sludge produced yearly creates a severe pollution problem to environment , and thus needs either to be properly disposed of , or recovered .',
  'Filamentous bulking sludge due to excessive growth of filamentous bacteria is a serious operational problem in activated sludge plants .',
  'These waste materials in large quantities can create a serious environmental problem .',
  'Removal of sludges from Wastewater Treatment Plants ( WWTP ) represents a serious worldwide environmental problem for which alternatives other than their simple incineration are investigated .',
  'The enormous amount of Ulva biomass thus becomes a troublesome waste disposal problem .',
  'The disposal of solid waste is a serious problem worldwide that is made worse in developing countries due to inadequate planning and unsustainable solid waste management .',
  'The enormous quantities of municipal solid waste ( MSW ) generation in Indian cities has emerged as a serious concern .',
  'Large filamentous populations were present in about 60 % of the plants , which means that bulking of activated sludge , which is no longer a serious problem in modern domestic nutrient removal plants , still occurs frequently in industrial treatment plants .',
  'Settling problems caused by pin-point sludge constitute a serious problem in biological wastewater treatment , particularly in many industrial plants .',
  'The disposal of construction and demolition ( C&D ) waste has become a serious problem in China due to the rapid increase of Chinese construction industry in recent years .',
  'Management of household solid waste and agro industrial residues generated from various sources is a serious problem due to huge ever increasing population and pollution .',
  'Household solid waste management is a severe problem in big cities of developing countries . Mismanaged solid waste dumpsites produce bad sanitary , ecological and economic consequences for the whole population , especially for the poorest urban inhabitants .',
  'Sewage sludge is a serious problem due to the high treatment costs and the risks to environment and human health .',
  'This , together with the fact that in many European countries the rate of recycling and reuse of C&DW is still quite low has engendered a serious environmental problem and a motivation to develop strategies and management plans to solve it .',
  'The current practice of the illegal dumping of solid waste on the river banks has created a serious environmental and public health problem .'],
 'trials': ['A problem with the BPS model is that it has not been operationalized in terms of patient behavior .',
  'A commonly reported problem with the conduct of multicentre randomised controlled trials ( RCTs ) is that recruitment is often slower or more difficult than expected , with many trials failing to reach their planned sample size within the timescale and funding originally envisaged .',
  'The problem with these studies and the guidelines is that they are not very easy to interpret , they include controversial issues , and they are not easy to apply to every patient or country .',
  'The problem with studies published to date is that there are many limitations , not least of which is the challenge of achieving patient adherence with performing incentive spirometry as prescribed .',
  'A problem with the trial was that on available ( inconclusive ) evidence it appeared that one patient out of 500 was killed by the drug .',
  'One potential problem with its use in the UK is that the test has been standardised on American children .',
  'A potential limitation with the study is that the MNA was used as gold standard among patients younger than 65 years .',
  'A limitation with randomized controlled trials is that , while they provide unbiased evidence of the efficacy of interventions , they do so under unreal conditions and in a very limited and highly selected patient population .',
  'The primary problem with their study is that it does not consider deterioration to CESR that occurs in CESI patients over time .',
  'The problem with these methods is that each of the two stages is usually agnostic about the role of the other one in addressing the clinical goal .',
  'A problem with using an undetectable hs-cTn cutoff is that this value may be defined differently among hospitals and is also difficult to monitor .',
  'One problem with our data is that we do not have patient level information for Medicare patients who did not have a knee replacement during the study period .',
  'A problem with the score summation approach toward case identification on screening scales is that different studies may find that different thresholds are optimal for distinguishing cases from noncases .',
  'The problem with this approach is that the investigator may inadvertently leave out the most beneficial treatment .',
  'The problem with this approach is that the population in clinical trials is a selected group of patients , which has the potential to bias results .',
  'A problem with meta-analyses that do not report absolute risks with drug vs placebo and that extract ORs instead of relative risks ( RRs ) from RCT data is that it is hard for the reader to know how to interpret the findings and communicate them to patients .',
  'The general problem with research is that its purpose does not necessarily benefit an individual patient now .',
  'A significant problem with large , randomized phase III trials is that improvements in therapy and supportive care can not be rapidly incorporated into treatment , and the question under study may quickly become obsolete .',
  'Even though generation of allocation sequence by simple randomisation procedure is easily facilitated , a major drawback of the technique is that treatment groups can by chance end up being dissimilar both in size and composition of prognostic factors .',
  'A major drawback of the trials is the limited number of patients included .',
  'Heterogeneity is a significant drawback of both clinical trials and systematic reviews .',
  'A major drawback of such designs is that early stopping may only occur at the conclusion of the first stage , even if lack of efficacy becomes apparent at any other time point over the course of the clinical trial .',
  'A drawback of using a Delphi process to generate a PIM list , as was done for the new German list , is that little scientific evidence is currently available for the evaluation of active substances , potential therapeutic alternatives , and indicated monitoring procedures .',
  'A serious drawback of current diagnostic models is the absence of a unified mathematical methodological approach to implementing these two stages .',
  'This represents a major drawback of biomedical literature , since the NNT allows health operators to understand how much effort is needed to prevent a given event .',
  'Unrepresentative sample selection is a serious problem for randomised trials in the drug dependence field .',
  'Insufficient patient enrollment in clinical trials remains a serious and costly problem and is often considered the most critical issue to solve for the clinical trials community .',
  'The underreporting of final results of Phase I oncology trials remains a serious problem .',
  'In addition , as longitudinal study designs become increasingly popular , missing data have become a serious issue , and the lack of methods to systematically address this problem has hampered the progress of research in the aforementioned fields .',
  'The decision was made to abbreviate the scheduled 3-day mission by approximately one day because of a threatening tropical storm in the recovery area , and a problem of communication with the spacecraft from the tracking stations .',
  "But this is a serious problem , for as data accumulate , it can be expected that there will be a discernible trend favoring one of the treatments prior to the point where we achieve the trial 's objective .",
  'At that time , the inappropriate exclusion of women from clinical trials was a serious problem .',
  'The small sample size in the studies was a serious shortcoming reducing the statistical heterogeneity and obscuring differences in outcome between drugs and between experimental conditions .',
  'This is a serious problem for international trials because they lack of a reliable measure of the effects of drugs .',
  'The risk of bias and heterogeneity among studies was a serious problem , decreasing the level of evidence .',
  'Despite missing data being a serious problem in extended follow-up studies , statistical approaches to addressing missing data were often inadequate .',
  'Substantial instances of missing data are a serious problem that undermines the scientific trustworthiness of causal conclusions from clinical trials .',
  'A Food and Drug Administration advisory committee raised missing data as a serious concern in their review of results from the ATLAS ACS 2 TIMI 51 study , a large clinical trial that assessed rivaroxaban for its ability to reduce the risk of cardiovascular death , myocardial infarction or stroke in patients with acute coronary syndrome .',
  'Patients who learned that they had been randomized to bevacizumab perceived higher risk of having a serious problem caused by treatment ( P \u2009 = \u2009 .01 ) .',
  'Confounding by indication is a vexing problem , especially in evaluating treatment effects using observational data , since treatment decisions are often related to disease severity , prognosis , and frailty .',
  'Selective reporting of outcomes in clinical trials is a serious problem .',
  'When variation of treatment effects across individuals is plausible , lack of generalizability should be a serious concern .',
  'These analyses highlight a serious concern in analyses of risk factors for complex clinical constructs -- the likelihood of differential misclassification with respect to the risk factors of interest in scales with multiple , wide-ranging domains .',
  'Obtaining an inadequate sample is a serious problem that can invalidate an entire study .',
  'In experimental aging research the handling of censored data imposes a serious problem in the calculation of survival curves of partly censored populations and the statistical comparison of such populations .',
  'In longitudinal studies where the same individuals are followed over time , bias caused by unobserved data raises a serious concern , particularly when the data are missing in a non-ignorable manner .'],
 'peptide': ['A major problem , however , with these arginine-rich peptides is that they frequently remain trapped in endosomal compartments following internalization .',
  'However , a major problem associated with peptide therapies is that they are poorly taken up by APCs .',
  'In summary , we have demonstrated that lipophilicity can be conferred to hydrophilic peptides to a degree permitting the permeation of the BBB by passive diffusion , without the drawback of agonist inactivation , which is often caused by irreversible derivatization .',
  'A drawback of this approach , however , is that once synthesis of the peptide is complete , regeneration of the thioamide requires the toxic , corrosive , and flammable gas H',
  'A major drawback of therapeutic peptides is their short half-life , which results in the need for multiple applications and high synthesis costs .',
  'High turnover rate of hepcidin is a major drawback of therapies directly targeting this peptide .',
  'This relatively small 37-amino acid peptide constitutes a serious scientific , research and to some extent a medical problem .',
  'As demonstrated here , peptide-based drug discovery could be a serious option for addressing new therapeutic challenges .',
  'Over the last few decades , scientific interest in food-derived bioactive peptides has grown as an alternative to pharmacological treatments in the control of lifestyle-associated diseases , which represent a serious health problem worldwide .',
  'This relatively small , 37-amino acid peptide constitutes a serious scientific , research and to some extent a medical problem .'],
 'peptides': ['A major problem , however , with these arginine-rich peptides is that they frequently remain trapped in endosomal compartments following internalization .',
  'However , a major problem associated with peptide therapies is that they are poorly taken up by APCs .',
  'In summary , we have demonstrated that lipophilicity can be conferred to hydrophilic peptides to a degree permitting the permeation of the BBB by passive diffusion , without the drawback of agonist inactivation , which is often caused by irreversible derivatization .',
  'A drawback of this approach , however , is that once synthesis of the peptide is complete , regeneration of the thioamide requires the toxic , corrosive , and flammable gas H',
  'A major drawback of therapeutic peptides is their short half-life , which results in the need for multiple applications and high synthesis costs .',
  'High turnover rate of hepcidin is a major drawback of therapies directly targeting this peptide .',
  'This relatively small 37-amino acid peptide constitutes a serious scientific , research and to some extent a medical problem .',
  'As demonstrated here , peptide-based drug discovery could be a serious option for addressing new therapeutic challenges .',
  'Over the last few decades , scientific interest in food-derived bioactive peptides has grown as an alternative to pharmacological treatments in the control of lifestyle-associated diseases , which represent a serious health problem worldwide .',
  'This relatively small , 37-amino acid peptide constitutes a serious scientific , research and to some extent a medical problem .'],
 'amino': ['A major problem , however , with these arginine-rich peptides is that they frequently remain trapped in endosomal compartments following internalization .',
  'However , a major problem associated with peptide therapies is that they are poorly taken up by APCs .',
  'In summary , we have demonstrated that lipophilicity can be conferred to hydrophilic peptides to a degree permitting the permeation of the BBB by passive diffusion , without the drawback of agonist inactivation , which is often caused by irreversible derivatization .',
  'A drawback of this approach , however , is that once synthesis of the peptide is complete , regeneration of the thioamide requires the toxic , corrosive , and flammable gas H',
  'A major drawback of therapeutic peptides is their short half-life , which results in the need for multiple applications and high synthesis costs .',
  'High turnover rate of hepcidin is a major drawback of therapies directly targeting this peptide .',
  'This relatively small 37-amino acid peptide constitutes a serious scientific , research and to some extent a medical problem .',
  'As demonstrated here , peptide-based drug discovery could be a serious option for addressing new therapeutic challenges .',
  'Over the last few decades , scientific interest in food-derived bioactive peptides has grown as an alternative to pharmacological treatments in the control of lifestyle-associated diseases , which represent a serious health problem worldwide .',
  'This relatively small , 37-amino acid peptide constitutes a serious scientific , research and to some extent a medical problem .'],
 'propofol': ['One problem with it is that the insertion of a cotton-tipped applicator soaked in local anesthetic is painful .',
  'However , a major drawback of sedation with the use of propofol is its high incidence of injection pain .',
  'A common drawback of propofol is pain on injection and lidocaine is commonly mixed with propofol to reduce its incidence and severity .',
  'Alghedon patch contains part of the drug ( approximately 15 % ) in the skin-contact adhesive : this innovative solution allows to overcome a typical drawback of transdermal patches , i.e. the long lag-time before the drug appears in plasma after the first administration , and provides rapid analgesia during the first hours of administration .',
  'Though propofol is a widely used anesthetic agent in day-care procedures due to its rapid onset and quick recovery has a drawback of requiring resuscitation maneuvers more often than the conventional methods .',
  'However , a major drawback of sedation with the use of propofol is its high incidence of injection pain .',
  'An assessment of health risk of exposure to these inhalant anesthetics poses a serious problem for employers , mostly due to the fact that maximum admissible concentrations ( MAC ) for these compounds have not been established .',
  'However , since volatile anaesthetics are probably not the most important risk factors , it might be even better -- if appropriate -- to avoid general anaesthesia by using a regional , opioid-free anaesthesia if PONV is a serious problem .',
  'A serious problem for a pediatrician is the iatrogenic OP resulting from a long-term use of some medicines ( glucocorticosteroids , hydantoin derivatives , barbiturates ) , or long-lasting immobilization for surgical and orthopaedic reasons , or from chronic general diseases .',
  'A serious problem for a paediatrician is the iatrogenic OP resulting from a long-term use of some medicines ( glucocorticosteroids ) or long-lasting immobilization for surgical and orthopaedic reasons , or from chronic general diseases .',
  'Neurotoxicity of spinally administered hyperbaric 5 % lidocaine is becoming a serious concern in view of the recent literature .',
  'However , their systemic administration may more frequently associate with their well-known side-effect , sedation , which is a serious problem in persons in safety-critical jobs such as aviation .'],
 'sedation': ['One problem with it is that the insertion of a cotton-tipped applicator soaked in local anesthetic is painful .',
  'However , a major drawback of sedation with the use of propofol is its high incidence of injection pain .',
  'A common drawback of propofol is pain on injection and lidocaine is commonly mixed with propofol to reduce its incidence and severity .',
  'Alghedon patch contains part of the drug ( approximately 15 % ) in the skin-contact adhesive : this innovative solution allows to overcome a typical drawback of transdermal patches , i.e. the long lag-time before the drug appears in plasma after the first administration , and provides rapid analgesia during the first hours of administration .',
  'Though propofol is a widely used anesthetic agent in day-care procedures due to its rapid onset and quick recovery has a drawback of requiring resuscitation maneuvers more often than the conventional methods .',
  'However , a major drawback of sedation with the use of propofol is its high incidence of injection pain .',
  'An assessment of health risk of exposure to these inhalant anesthetics poses a serious problem for employers , mostly due to the fact that maximum admissible concentrations ( MAC ) for these compounds have not been established .',
  'However , since volatile anaesthetics are probably not the most important risk factors , it might be even better -- if appropriate -- to avoid general anaesthesia by using a regional , opioid-free anaesthesia if PONV is a serious problem .',
  'A serious problem for a pediatrician is the iatrogenic OP resulting from a long-term use of some medicines ( glucocorticosteroids , hydantoin derivatives , barbiturates ) , or long-lasting immobilization for surgical and orthopaedic reasons , or from chronic general diseases .',
  'A serious problem for a paediatrician is the iatrogenic OP resulting from a long-term use of some medicines ( glucocorticosteroids ) or long-lasting immobilization for surgical and orthopaedic reasons , or from chronic general diseases .',
  'Neurotoxicity of spinally administered hyperbaric 5 % lidocaine is becoming a serious concern in view of the recent literature .',
  'However , their systemic administration may more frequently associate with their well-known side-effect , sedation , which is a serious problem in persons in safety-critical jobs such as aviation .'],
 'lidocaine': ['One problem with it is that the insertion of a cotton-tipped applicator soaked in local anesthetic is painful .',
  'However , a major drawback of sedation with the use of propofol is its high incidence of injection pain .',
  'A common drawback of propofol is pain on injection and lidocaine is commonly mixed with propofol to reduce its incidence and severity .',
  'Alghedon patch contains part of the drug ( approximately 15 % ) in the skin-contact adhesive : this innovative solution allows to overcome a typical drawback of transdermal patches , i.e. the long lag-time before the drug appears in plasma after the first administration , and provides rapid analgesia during the first hours of administration .',
  'Though propofol is a widely used anesthetic agent in day-care procedures due to its rapid onset and quick recovery has a drawback of requiring resuscitation maneuvers more often than the conventional methods .',
  'However , a major drawback of sedation with the use of propofol is its high incidence of injection pain .',
  'An assessment of health risk of exposure to these inhalant anesthetics poses a serious problem for employers , mostly due to the fact that maximum admissible concentrations ( MAC ) for these compounds have not been established .',
  'However , since volatile anaesthetics are probably not the most important risk factors , it might be even better -- if appropriate -- to avoid general anaesthesia by using a regional , opioid-free anaesthesia if PONV is a serious problem .',
  'A serious problem for a pediatrician is the iatrogenic OP resulting from a long-term use of some medicines ( glucocorticosteroids , hydantoin derivatives , barbiturates ) , or long-lasting immobilization for surgical and orthopaedic reasons , or from chronic general diseases .',
  'A serious problem for a paediatrician is the iatrogenic OP resulting from a long-term use of some medicines ( glucocorticosteroids ) or long-lasting immobilization for surgical and orthopaedic reasons , or from chronic general diseases .',
  'Neurotoxicity of spinally administered hyperbaric 5 % lidocaine is becoming a serious concern in view of the recent literature .',
  'However , their systemic administration may more frequently associate with their well-known side-effect , sedation , which is a serious problem in persons in safety-critical jobs such as aviation .'],
 'injection': ['One problem with it is that the insertion of a cotton-tipped applicator soaked in local anesthetic is painful .',
  'However , a major drawback of sedation with the use of propofol is its high incidence of injection pain .',
  'A common drawback of propofol is pain on injection and lidocaine is commonly mixed with propofol to reduce its incidence and severity .',
  'Alghedon patch contains part of the drug ( approximately 15 % ) in the skin-contact adhesive : this innovative solution allows to overcome a typical drawback of transdermal patches , i.e. the long lag-time before the drug appears in plasma after the first administration , and provides rapid analgesia during the first hours of administration .',
  'Though propofol is a widely used anesthetic agent in day-care procedures due to its rapid onset and quick recovery has a drawback of requiring resuscitation maneuvers more often than the conventional methods .',
  'However , a major drawback of sedation with the use of propofol is its high incidence of injection pain .',
  'An assessment of health risk of exposure to these inhalant anesthetics poses a serious problem for employers , mostly due to the fact that maximum admissible concentrations ( MAC ) for these compounds have not been established .',
  'However , since volatile anaesthetics are probably not the most important risk factors , it might be even better -- if appropriate -- to avoid general anaesthesia by using a regional , opioid-free anaesthesia if PONV is a serious problem .',
  'A serious problem for a pediatrician is the iatrogenic OP resulting from a long-term use of some medicines ( glucocorticosteroids , hydantoin derivatives , barbiturates ) , or long-lasting immobilization for surgical and orthopaedic reasons , or from chronic general diseases .',
  'A serious problem for a paediatrician is the iatrogenic OP resulting from a long-term use of some medicines ( glucocorticosteroids ) or long-lasting immobilization for surgical and orthopaedic reasons , or from chronic general diseases .',
  'Neurotoxicity of spinally administered hyperbaric 5 % lidocaine is becoming a serious concern in view of the recent literature .',
  'However , their systemic administration may more frequently associate with their well-known side-effect , sedation , which is a serious problem in persons in safety-critical jobs such as aviation .'],
 'doppler': ['The problem with the delayed CT technique is that since measurements are made at 2 hours and onward , it is applicable only to patients who have received larger doses of contrast .',
  'The problem with virtual vascular 3D-CT endoscopic images is that endoscopic findings in the vascular wall are incomplete because of the partial volume effect and pulsation of the aneurysm and vascular wall .',
  'A problem with the use of ultrasonography is that the mild lesions likely to be observed in population surveys are not always easy to assess .',
  'A drawback of the technique is that it is difficult to distinguish between small gaseous emboli and large solid emboli .',
  'A major drawback of the technique is that only the elastic pulmonary arteries are accessible to current ultrasound catheters .',
  'A drawback of both methods was the large number of not evaluable arteries ( 6 in MRA , 11 in color Doppler sonography ) .',
  'However , the presence of HCC nodules that are inconspicuous when using conventional sonography is a major drawback of RFA and limits its feasibility as a treatment for HCC .',
  'Usage of color Doppler and duplex Doppler ultrasonography has greatly contributed to diagnostic efficiency , while therapeutically , the disease remains a serious and controversial problem .',
  'The radiographic representation of soft tissues and body cavities was more difficult and the development of contrast agents in particular posed a serious problem .',
  'The results confirm the suspicion that considerable output variations exist and suggest a serious problem to the practitioner wishing to expand his radiographic technique armementarium .'],
 'emboli': ['The problem with the delayed CT technique is that since measurements are made at 2 hours and onward , it is applicable only to patients who have received larger doses of contrast .',
  'The problem with virtual vascular 3D-CT endoscopic images is that endoscopic findings in the vascular wall are incomplete because of the partial volume effect and pulsation of the aneurysm and vascular wall .',
  'A problem with the use of ultrasonography is that the mild lesions likely to be observed in population surveys are not always easy to assess .',
  'A drawback of the technique is that it is difficult to distinguish between small gaseous emboli and large solid emboli .',
  'A major drawback of the technique is that only the elastic pulmonary arteries are accessible to current ultrasound catheters .',
  'A drawback of both methods was the large number of not evaluable arteries ( 6 in MRA , 11 in color Doppler sonography ) .',
  'However , the presence of HCC nodules that are inconspicuous when using conventional sonography is a major drawback of RFA and limits its feasibility as a treatment for HCC .',
  'Usage of color Doppler and duplex Doppler ultrasonography has greatly contributed to diagnostic efficiency , while therapeutically , the disease remains a serious and controversial problem .',
  'The radiographic representation of soft tissues and body cavities was more difficult and the development of contrast agents in particular posed a serious problem .',
  'The results confirm the suspicion that considerable output variations exist and suggest a serious problem to the practitioner wishing to expand his radiographic technique armementarium .'],
 'ultrasonography': ['The problem with the delayed CT technique is that since measurements are made at 2 hours and onward , it is applicable only to patients who have received larger doses of contrast .',
  'The problem with virtual vascular 3D-CT endoscopic images is that endoscopic findings in the vascular wall are incomplete because of the partial volume effect and pulsation of the aneurysm and vascular wall .',
  'A problem with the use of ultrasonography is that the mild lesions likely to be observed in population surveys are not always easy to assess .',
  'A drawback of the technique is that it is difficult to distinguish between small gaseous emboli and large solid emboli .',
  'A major drawback of the technique is that only the elastic pulmonary arteries are accessible to current ultrasound catheters .',
  'A drawback of both methods was the large number of not evaluable arteries ( 6 in MRA , 11 in color Doppler sonography ) .',
  'However , the presence of HCC nodules that are inconspicuous when using conventional sonography is a major drawback of RFA and limits its feasibility as a treatment for HCC .',
  'Usage of color Doppler and duplex Doppler ultrasonography has greatly contributed to diagnostic efficiency , while therapeutically , the disease remains a serious and controversial problem .',
  'The radiographic representation of soft tissues and body cavities was more difficult and the development of contrast agents in particular posed a serious problem .',
  'The results confirm the suspicion that considerable output variations exist and suggest a serious problem to the practitioner wishing to expand his radiographic technique armementarium .'],
 'sonography': ['The problem with the delayed CT technique is that since measurements are made at 2 hours and onward , it is applicable only to patients who have received larger doses of contrast .',
  'The problem with virtual vascular 3D-CT endoscopic images is that endoscopic findings in the vascular wall are incomplete because of the partial volume effect and pulsation of the aneurysm and vascular wall .',
  'A problem with the use of ultrasonography is that the mild lesions likely to be observed in population surveys are not always easy to assess .',
  'A drawback of the technique is that it is difficult to distinguish between small gaseous emboli and large solid emboli .',
  'A major drawback of the technique is that only the elastic pulmonary arteries are accessible to current ultrasound catheters .',
  'A drawback of both methods was the large number of not evaluable arteries ( 6 in MRA , 11 in color Doppler sonography ) .',
  'However , the presence of HCC nodules that are inconspicuous when using conventional sonography is a major drawback of RFA and limits its feasibility as a treatment for HCC .',
  'Usage of color Doppler and duplex Doppler ultrasonography has greatly contributed to diagnostic efficiency , while therapeutically , the disease remains a serious and controversial problem .',
  'The radiographic representation of soft tissues and body cavities was more difficult and the development of contrast agents in particular posed a serious problem .',
  'The results confirm the suspicion that considerable output variations exist and suggest a serious problem to the practitioner wishing to expand his radiographic technique armementarium .'],
 'radiographic': ['The problem with the delayed CT technique is that since measurements are made at 2 hours and onward , it is applicable only to patients who have received larger doses of contrast .',
  'The problem with virtual vascular 3D-CT endoscopic images is that endoscopic findings in the vascular wall are incomplete because of the partial volume effect and pulsation of the aneurysm and vascular wall .',
  'A problem with the use of ultrasonography is that the mild lesions likely to be observed in population surveys are not always easy to assess .',
  'A drawback of the technique is that it is difficult to distinguish between small gaseous emboli and large solid emboli .',
  'A major drawback of the technique is that only the elastic pulmonary arteries are accessible to current ultrasound catheters .',
  'A drawback of both methods was the large number of not evaluable arteries ( 6 in MRA , 11 in color Doppler sonography ) .',
  'However , the presence of HCC nodules that are inconspicuous when using conventional sonography is a major drawback of RFA and limits its feasibility as a treatment for HCC .',
  'Usage of color Doppler and duplex Doppler ultrasonography has greatly contributed to diagnostic efficiency , while therapeutically , the disease remains a serious and controversial problem .',
  'The radiographic representation of soft tissues and body cavities was more difficult and the development of contrast agents in particular posed a serious problem .',
  'The results confirm the suspicion that considerable output variations exist and suggest a serious problem to the practitioner wishing to expand his radiographic technique armementarium .'],
 'arteries': ['The problem with the delayed CT technique is that since measurements are made at 2 hours and onward , it is applicable only to patients who have received larger doses of contrast .',
  'The problem with virtual vascular 3D-CT endoscopic images is that endoscopic findings in the vascular wall are incomplete because of the partial volume effect and pulsation of the aneurysm and vascular wall .',
  'A problem with the use of ultrasonography is that the mild lesions likely to be observed in population surveys are not always easy to assess .',
  'A drawback of the technique is that it is difficult to distinguish between small gaseous emboli and large solid emboli .',
  'A major drawback of the technique is that only the elastic pulmonary arteries are accessible to current ultrasound catheters .',
  'A drawback of both methods was the large number of not evaluable arteries ( 6 in MRA , 11 in color Doppler sonography ) .',
  'However , the presence of HCC nodules that are inconspicuous when using conventional sonography is a major drawback of RFA and limits its feasibility as a treatment for HCC .',
  'Usage of color Doppler and duplex Doppler ultrasonography has greatly contributed to diagnostic efficiency , while therapeutically , the disease remains a serious and controversial problem .',
  'The radiographic representation of soft tissues and body cavities was more difficult and the development of contrast agents in particular posed a serious problem .',
  'The results confirm the suspicion that considerable output variations exist and suggest a serious problem to the practitioner wishing to expand his radiographic technique armementarium .'],
 'allergic': ['The basic problem with diagnostic tests such as skin prick test ( SPT ) , measurement of specific IgE ( RAST ) or histamine release from basophils ( HR ) is that in contrast to inhalant allergens , no standardized extracts are commercially available .',
  'Anyone who suffers from hayfever will know what a serious problem allergies can be .',
  'Allergy is a serious and apparently increasing public health problem yet relatively little is known about the types of allergy seen in routine tertiary practice , including their spatial distribution , co-occurrence or referral patterns .',
  'Type I allergy represents a severe health problem in industrialized countries where up to 20 % of the population suffer from allergic rhinitis , conjunctivitis and allergic asthma bronchiale and in severe cases from anaphylaxis , leading to death .',
  'The increase in allergic reactions compels the anaesthetist to exercise great care when administering anaesthetics exclusively intravenously , because anaphylactic or anaphylactoid reactions can become a life-threatening problem for the patient within a very short time .',
  'Drug allergic reactions frequently represent a serious diagnostic problem .',
  'Antihistamine use does not appear to be a serious problem .',
  'Allergic conditions present a serious problem for the Polish population .',
  'However , its allergenic reactions , being the main adverse effects ( AEs ) of SHLPI , have been a serious problem of its clinical safety .',
  'However , having a chronic disease like a severe allergy may add stress and challenges beyond normal development and involves a struggle between adapting socially , feeling healthy , and managing the disease .',
  'Allergic disease is a serious problem in practical healthcare .',
  'Given that during OIT an allergic patient ingests an allergen that could potentially cause a serious reaction , the safety of OIT is of particular concern .',
  'Allergy to short ragweed ( Ambrosia artemisiifolia ) pollen is a serious and expanding health problem in North America and Europe .',
  'Allergic reactions to drugs are a serious public health concern .',
  'Changes in complement and coagulation factors in a patient suffering a severe anaphylactoid reaction to injected contrast material : some considerations of pathogenesis .',
  'Type I allergy represents a severe health problem in industrialized countries where up to 20 % of the population suffers from allergic rhinitis , conjunctivitis and allergic asthma bronchiale and in severe cases from anaphylaxis , leading to death .',
  'Childhood allergies are a serious problem , as they may lead to lifetime chronic disease .',
  'In conclusion , the present study shows that anaphylaxis represents a serious and relevant medical problem in the pediatric population and should be ever carefully managed .',
  'Mouse allergy in both laboratory workers and in inner-city children is associated with allergic rhinitis and asthma , posing a serious public health concern .',
  'Although anaphylaxis continues to be recognized as a life-threatening clinical problem , efforts to develop in-vitro methods for diagnosis and verification continue .',
  'One patient with a fatal outcome was initially diagnosed as allergic alveolitis rather than infection and received steroid treatment illustrating the obvious challenges in the differential diagnosis between these disease entities .',
  ': Allergy is a serious problem affecting approximately 1 of 4 individuals .',
  'In conclusion , the present study shows that anaphylaxis represents a serious and relevant medical problem in the general population at any age , and should always be carefully managed .',
  'From our experience we conclude that dextran-induced anaphylactoid reactions are still a serious problem despite immunoprophylaxis .',
  'Allergic diseases represent a serious public health problem all over the world , and they use to be associated with environmental factors as well as with each patient genetic predisposition .',
  'Wrong concepts related to anaphylaxis treatment are frequently observed and this is a serious problem since GPs are the front-line doctors in the management of out-patient anaphylactic reactions and therefore it is absolutely mandatory that they can be able not only to accurately diagnose and treat an acute anaphylactic episode but also to make a correct retrospective diagnosis and to advise on the use of epinephrine auto-injectors .',
  'Anaphylaxis is a life-threatening , systemic allergic reaction that presents unique challenges for emergency care practitioners .',
  'Heparin-induced IgE-mediated hypersensitivity and anaphylactoid reactions , although rare , can pose a serious clinical problem for patients requiring cardiopulmonary bypass ( CPB ) .',
  'Anaphylaxis is a severe life-threatening systemic reaction that offers many challenges to the clinician .',
  'Perioperative anaphylactic shock is a serious problem due to the difficulty of judgment and potentially disastrous outcome .',
  'Allergy prevention remains a vexing problem .'],
 'anaphylaxis': ['The basic problem with diagnostic tests such as skin prick test ( SPT ) , measurement of specific IgE ( RAST ) or histamine release from basophils ( HR ) is that in contrast to inhalant allergens , no standardized extracts are commercially available .',
  'Anyone who suffers from hayfever will know what a serious problem allergies can be .',
  'Allergy is a serious and apparently increasing public health problem yet relatively little is known about the types of allergy seen in routine tertiary practice , including their spatial distribution , co-occurrence or referral patterns .',
  'Type I allergy represents a severe health problem in industrialized countries where up to 20 % of the population suffer from allergic rhinitis , conjunctivitis and allergic asthma bronchiale and in severe cases from anaphylaxis , leading to death .',
  'The increase in allergic reactions compels the anaesthetist to exercise great care when administering anaesthetics exclusively intravenously , because anaphylactic or anaphylactoid reactions can become a life-threatening problem for the patient within a very short time .',
  'Drug allergic reactions frequently represent a serious diagnostic problem .',
  'Antihistamine use does not appear to be a serious problem .',
  'Allergic conditions present a serious problem for the Polish population .',
  'However , its allergenic reactions , being the main adverse effects ( AEs ) of SHLPI , have been a serious problem of its clinical safety .',
  'However , having a chronic disease like a severe allergy may add stress and challenges beyond normal development and involves a struggle between adapting socially , feeling healthy , and managing the disease .',
  'Allergic disease is a serious problem in practical healthcare .',
  'Given that during OIT an allergic patient ingests an allergen that could potentially cause a serious reaction , the safety of OIT is of particular concern .',
  'Allergy to short ragweed ( Ambrosia artemisiifolia ) pollen is a serious and expanding health problem in North America and Europe .',
  'Allergic reactions to drugs are a serious public health concern .',
  'Changes in complement and coagulation factors in a patient suffering a severe anaphylactoid reaction to injected contrast material : some considerations of pathogenesis .',
  'Type I allergy represents a severe health problem in industrialized countries where up to 20 % of the population suffers from allergic rhinitis , conjunctivitis and allergic asthma bronchiale and in severe cases from anaphylaxis , leading to death .',
  'Childhood allergies are a serious problem , as they may lead to lifetime chronic disease .',
  'In conclusion , the present study shows that anaphylaxis represents a serious and relevant medical problem in the pediatric population and should be ever carefully managed .',
  'Mouse allergy in both laboratory workers and in inner-city children is associated with allergic rhinitis and asthma , posing a serious public health concern .',
  'Although anaphylaxis continues to be recognized as a life-threatening clinical problem , efforts to develop in-vitro methods for diagnosis and verification continue .',
  'One patient with a fatal outcome was initially diagnosed as allergic alveolitis rather than infection and received steroid treatment illustrating the obvious challenges in the differential diagnosis between these disease entities .',
  ': Allergy is a serious problem affecting approximately 1 of 4 individuals .',
  'In conclusion , the present study shows that anaphylaxis represents a serious and relevant medical problem in the general population at any age , and should always be carefully managed .',
  'From our experience we conclude that dextran-induced anaphylactoid reactions are still a serious problem despite immunoprophylaxis .',
  'Allergic diseases represent a serious public health problem all over the world , and they use to be associated with environmental factors as well as with each patient genetic predisposition .',
  'Wrong concepts related to anaphylaxis treatment are frequently observed and this is a serious problem since GPs are the front-line doctors in the management of out-patient anaphylactic reactions and therefore it is absolutely mandatory that they can be able not only to accurately diagnose and treat an acute anaphylactic episode but also to make a correct retrospective diagnosis and to advise on the use of epinephrine auto-injectors .',
  'Anaphylaxis is a life-threatening , systemic allergic reaction that presents unique challenges for emergency care practitioners .',
  'Heparin-induced IgE-mediated hypersensitivity and anaphylactoid reactions , although rare , can pose a serious clinical problem for patients requiring cardiopulmonary bypass ( CPB ) .',
  'Anaphylaxis is a severe life-threatening systemic reaction that offers many challenges to the clinician .',
  'Perioperative anaphylactic shock is a serious problem due to the difficulty of judgment and potentially disastrous outcome .',
  'Allergy prevention remains a vexing problem .'],
 'praziquantel': ['A basic problem with the current approach to controlling resistance is that the two most common strategies , highly restrictive formularies and drug cycling , work in opposition .',
  'A major drawback of lamivudine treatment is the development of resistance , observed in 15 - 20 % of patients after 1 year and up to 70 % after 5 years of continued treatment .',
  'Treatment retention increased , thus potentially preventing drug resistance , a serious problem in the Republic of Moldova .',
  'This phenomenon , which we call super-resistance , is becoming a serious concern .',
  'Arso PIR has a severe drug resistance problem .',
  'However , their overuse has led to a serious problem of increasing drug resistance .',
  'Multidrug resistance is a serious problem .',
  'Acaricide resistance is a serious problem , with regional variation in resistance levels .',
  'However , the development of drug resistance against those medicines is becoming a serious concern .',
  'Strong selective pressure has caused a serious concern for a rise in resistance to praziquantel leading to the necessity for additional pharmaceuticals , with a distinctly different mechanism of action , to be used in combination therapy with praziquantel .',
  'Above all , resistance to existing drugs is widespread and has become a serious problem threatening the success of control measures .',
  'Drug resistance is a serious problem , especially in the United States .',
  'Resistance to this agent poses a serious clinical dilemma .',
  'However , resistance is occurred and becomes a serious clinical concern .',
  'Although still uncommon , resistance to CAZ-AVI has emerged and may represents a serious cause of concern .'],
 'foodborne': ['The problem with these two approaches is that they are either overly inclusive ( i.e. , detect all bacteria of a given species regardless of spoilage potential ) or overly selective ( i.e. , rely upon individual , putative spoilage-associated genes ) .',
  'Staphylococcus food poisoning still a serious problem .',
  'Listeriosis is a serious foodborne disease of a global concern , and can effectively be controlled by a continuous surveillance of the virulent and multidrug-resistant strains of Listeria monocytogenes .',
  'Staphylococcus food poisoning still a serious problem .',
  'Listeria monocytogenes is a food-borne human pathogen and a serious concern in food production and preservation .',
  'Foodborne disease caused by Vibrio parahaemolyticus is a serious public health problem in many countries .',
  'Foodborne illness caused by L. monocytogenes is a serious public health concern because of the high associated mortality .',
  'Airway infections with Listeria monocytogenes , although representing a serious problem in early onset neonatal listeriosis , has not been investigated in detail in animal models so far .',
  'Physicians were more likely to provide food-safety information to patients if they perceived foodborne disease to be a serious problem , perceived food-safety education as their role , felt that patients perceived them as a valuable resource for food-safety advice , or felt comfortable making food-safety recommendations .',
  'The fact that anhydrobiotic organisms escape treatments with biocides should be considered a serious problem , both for the food industry and from the perspective of human-mediated spread of organisms .',
  'Foodborne illness is a serious and preventable public health problem affecting 1 in 6 Americans with cost estimates over $ 50 billion annually .',
  'The Gram-positive bacterium Listeria monocytogenes is a human foodborne pathogen that remains a serious public health concern .',
  'Infectious diseases spreading every day through food have become a life-threatening problem for millions of people around the world .',
  'The model was applied to ovine listeriosis , which is a serious disease problem in Norway .',
  'Bacterial cross-contamination and recontamination during household food preparation could play an important role in the dissemination of such bacteria , and therefore could contribute to a serious health problem , more specifically for immunocompromised people .',
  'Frequently cited statistics indicate that the burden of foodborne disease is a serious public health problem , particularly for vulnerable populations such as children .',
  'It is a quantitative presentation of just what these dangers are in public restaurants . They constitute a vexing problem to every health officer , and he needs the plain facts for the education of his public . With these , his people will back him in efforts to improve such places .',
  'Foodborne illness is a serious and preventable public health problem , with high health and economic tolls in the United States .',
  'Listeria monocytogenes , the etiologic agent of listeriosis , remains a serious public health concern , with its frequent occurrence in food environments coupled with a high mortality rate .',
  'Food contamination due to the presence of microorganisms is a serious problem .',
  'Foodborne illness is a serious public health concern .',
  'Bacterial contamination continues to be a serious concern for food safety .',
  'Listeria monocytogenes , the etiologic agent of listeriosis , remains a serious public health concern with its frequent occurrence in food coupled with a high mortality rate .',
  'Listeria monocytogenes is an important cause of human foodborne infections and its ability to form biofilms is a serious concern to the food industry .',
  'Listeria monocytogenes , a foodborne pathogenic bacterium , remains a serious public health concern due to its frequent occurrence in food products coupled with a high mortality rate .',
  'Foodborne illness is a serious public health problem .',
  'The contamination of enterotoxigenic Clostridium perfringens spores on food contact surfaces posses a serious concern to food industry due to their high resistance to various preservation methods typically applied to control foodborne pathogens .',
  'Our findings revealed that B. cereus must be considered a serious health hazard and Bacillus thuringiensis should be considered of a greater potential concern to food safety among all B. cereus group members .',
  'In recent years , food safety incidents become a serious social problem .',
  'Foodborne disease caused by pathogenic Vibrio parahaemolyticus has become a serious public health problem in many countries .',
  "Changes in consumers ' habits have led to an increase of convenient LPFP with a relative long shelf-life ( at least 3 weeks ) which , on the other hand , may constitute a serious problem from a safety perspective since Listeria monocytogenes and sometimes Clostridium botulinum ( mainly type E ) may able to grow .",
  'Foodborne illnesses caused by bacterial microorganisms are common worldwide and constitute a serious public health concern .',
  'Food contamination by pathogenic microorganisms has been a serious public health problem and a cause of huge economic losses worldwide .',
  'Listeriosis is a serious problem because of the high mortality in case of generalized infection , which can reach up to 20 % .',
  'This study is aimed at evaluating the microbiological quality of the meals served in school lunchrooms for the purpose of ascertaining whether it is suitable or , to the contrary , the intake thereof may involve a serious health problem for this high-risk group .',
  'Food borne diseases are a serious public health problem .',
  'Foodborne disease outbreak caused by food microbiological contamination is a serious public health problem .',
  'Foodborne diseases caused by pathogens and toxins are a serious threat to food safety and human health ; thus , they are major concern to society .',
  'This rehydration method could have a role in the preparation of therapeutic feeds where microbiological contamination of the environment is a serious problem and availability of adequate water is not a limiting factor .',
  'Foodborne illnesses have always been a serious problem that threats public health , so it is necessary to develop a method that can detect the pathogens rapidly and sensitively .',
  'Foodborne illness resulting from infectious organisms occurring in vegetables and processed meat is a serious health concern in the United States .',
  'Contamination of Cronobacter spp . ( Enterobacter sakazakii ) in infant formulas and other food products is a severe problem .'],
 'food': ['The problem with these two approaches is that they are either overly inclusive ( i.e. , detect all bacteria of a given species regardless of spoilage potential ) or overly selective ( i.e. , rely upon individual , putative spoilage-associated genes ) .',
  'Staphylococcus food poisoning still a serious problem .',
  'Staphylococcus food poisoning still a serious problem .',
  'Foodborne disease caused by Vibrio parahaemolyticus is a serious public health problem in many countries .',
  'Household food insecurity is a serious public health concern in high-income countries .',
  'This study suggests that , to resolve such a serious food access problem , assistance policies , such as mobile grocery stores and lunch-box delivery , need to be activated in countries similar to Korea since this problem could potentially deteriorate the national medical finances as well as the regional and individual disparities .',
  'Physicians were more likely to provide food-safety information to patients if they perceived foodborne disease to be a serious problem , perceived food-safety education as their role , felt that patients perceived them as a valuable resource for food-safety advice , or felt comfortable making food-safety recommendations .',
  'The fact that anhydrobiotic organisms escape treatments with biocides should be considered a serious problem , both for the food industry and from the perspective of human-mediated spread of organisms .',
  'Foodborne illness is a serious and preventable public health problem affecting 1 in 6 Americans with cost estimates over $ 50 billion annually .',
  'Infectious diseases spreading every day through food have become a life-threatening problem for millions of people around the world .',
  'Food and nutrition insecurity continues to pose a serious global challenge , reflecting government shortcomings in meeting international obligations to ensure the availability , accessibility , and quality of food and to ensure the highest attainable standard of health of their peoples .',
  'Food scarcity is a serious problem for many developing as well as developed countries .',
  'Bacterial cross-contamination and recontamination during household food preparation could play an important role in the dissemination of such bacteria , and therefore could contribute to a serious health problem , more specifically for immunocompromised people .',
  'Frequently cited statistics indicate that the burden of foodborne disease is a serious public health problem , particularly for vulnerable populations such as children .',
  'It is a quantitative presentation of just what these dangers are in public restaurants . They constitute a vexing problem to every health officer , and he needs the plain facts for the education of his public . With these , his people will back him in efforts to improve such places .',
  'Foodborne illness is a serious and preventable public health problem , with high health and economic tolls in the United States .',
  'Food contamination due to the presence of microorganisms is a serious problem .',
  'Foodborne illness is a serious public health concern .',
  'Bacterial contamination continues to be a serious concern for food safety .',
  'Food insecurity is a serious public health concern , affecting approximately 15 million children in the U.S. alone .',
  'Household food insecurity is a serious public health concern in rich countries with developed economies closely associated with inequality .',
  'Food insecurity is a serious public health concern that disproportionately impacts minority groups .',
  'Foodborne illness is a serious public health problem .',
  'The contamination of enterotoxigenic Clostridium perfringens spores on food contact surfaces posses a serious concern to food industry due to their high resistance to various preservation methods typically applied to control foodborne pathogens .',
  'Our findings revealed that B. cereus must be considered a serious health hazard and Bacillus thuringiensis should be considered of a greater potential concern to food safety among all B. cereus group members .',
  'Three spotlights underpin this debt : 1 ) a severe contrast in diets and food security between regions , 2 ) a concern about the role that international agrifood trade is playing in regional food security , and 3 ) a mismatch between regional biocapacity and food security .',
  'In recent years , food safety incidents become a serious social problem .',
  'Food insecurity is thus not only a serious social concern but also a healthcare issue requiring the attention of UK health professionals .',
  'The lack of dietary diversity is a severe problem experienced by most poor households globally .',
  'Foodborne disease caused by pathogenic Vibrio parahaemolyticus has become a serious public health problem in many countries .',
  'Food security is a severe problem in the United States .',
  'Foodborne illnesses caused by bacterial microorganisms are common worldwide and constitute a serious public health concern .',
  'Food contamination by pathogenic microorganisms has been a serious public health problem and a cause of huge economic losses worldwide .',
  'This study is aimed at evaluating the microbiological quality of the meals served in school lunchrooms for the purpose of ascertaining whether it is suitable or , to the contrary , the intake thereof may involve a serious health problem for this high-risk group .',
  'Food borne diseases are a serious public health problem .',
  'Foodborne disease outbreak caused by food microbiological contamination is a serious public health problem .',
  'Foodborne diseases caused by pathogens and toxins are a serious threat to food safety and human health ; thus , they are major concern to society .',
  'This rehydration method could have a role in the preparation of therapeutic feeds where microbiological contamination of the environment is a serious problem and availability of adequate water is not a limiting factor .',
  'Foodborne illnesses have always been a serious problem that threats public health , so it is necessary to develop a method that can detect the pathogens rapidly and sensitively .',
  'Foodborne illness resulting from infectious organisms occurring in vegetables and processed meat is a serious health concern in the United States .',
  'Contamination of Cronobacter spp . ( Enterobacter sakazakii ) in infant formulas and other food products is a severe problem .',
  'In the Horn of Africa , scurvy is a serious public health problem for refugees who are dependent on standard relief food ( cereals , legumes , and oil ) .'],
 'aging': ['It is common to broadly group people of different ages into " generations " and to speak of distinctions between such groups in terms of " generational differences . " The problem with this practice , is that there exists no credible scientific evidence that ( a ) generations exist , ( b ) that people can be reliably classified into generational groups , and ( c ) that there are demonstrable differences between such groups .',
  'Amid the rapid ongoing shift from treating the elderly in hospitals to treating them at home , self-care by elderly people living alone is a serious and complicated problem .',
  '[ The aged , a serious problem ] .',
  'With the general aging of the population they represent a serious and growing public health concern .',
  "after the Great East Japan Earthquake in 2011 , inactivity and the homebound status of older victims in affected areas have been a serious public health concern owing to the victims ' prolonged existence as evacuees in mountainous areas .",
  'Over-hospitalization of institutionalized older adults remains a serious concern in the health care industry .',
  'In chronically ill homebound adults , symptom burden is a serious problem that needs to be addressed alongside primary and specialty care needs .',
  'In China , aging has become a serious social problem , and the number of empty-nest elderly is on the rise .',
  'Therefore , presenteeism is likely to become a serious public health problem .',
  'Aside from the cost , the lack of necessary care services is also a serious concern of community-based eldercare .',
  'Presenteeism is a serious emerging problem in an occupational setting .',
  'Disuse atrophy in the elderly is becoming a serious problem in many developed countries .',
  'The records of 6520 older people were studied ; 40.1 % of the participants studied had expressed the possibility of having three to five people available in case of a serious problem , and 83.6 % reported that the rest of the people around them were very interested in what happens to them .',
  'In industry this condition presents a serious problem to older workers , to employers and to insurance carriers .',
  'Thus , aging is a serious public health problem .',
  'In comparison , there is no country like Japan , which has a serious problem of an increasingly aging population , and where pharmacists play important roles in home care .',
  'While aging is a serious global concern , in-home healthcare monitoring solutions are limited to context-aware systems and wearable sensors , which may easily be forgotten or ignored for privacy and comfort reasons .',
  'The death of adults in their prime , who are parents , community leaders and producers in most societies , causes a particularly onerous burden besides being a serious public health problem .',
  'Hospital-associated deconditioning due to a combination of illness and inactivity is a serious problem for elderly adults .',
  'SI can be a serious problem among adolescents following a major earthquake , especially those who are older , who live in one-child households , or who are female .',
  "It is a serious problem facing the elderly in today 's society .",
  'Long-term care is becoming a serious concern as the population ages , women move into the workforce , and family size decreases .',
  'Although current models of care are generally well-suited to providing treatment for individual medical conditions , the emergence of multimorbidity is becoming a serious concern for practitioners and policy researchers , particularly in developing countries .',
  'Ageism is a serious problem in medical care .',
  'The rise in institutional care costs , such as that associated with care in chronic hospitals or nursing homes , is a serious social concern in Japan , and this is particularly so in rural areas which are more rapidly aging than others .',
  'An aging population has become a serious problem in China .',
  '( 3 ) Results : Multimorbidity was a serious health problem in rural , disease-causing poverty , older-age households , with the prevalence of multimorbidity estimated as 40 % for women and 35.4 % for men .',
  'Taiwan has been confronted with a serious problem of aging in recent years .',
  'Recently , emerging issues on the road involving the adult children of politically powerful families have become a serious social problem in China , and have drawn widespread media and public attention .',
  'The dry form of ARMD is becoming a serious problem because of the rise in the number of old individuals .',
  'PrUs were a serious problem in this community-dwelling economically vulnerable group , and home care played a critical role in providing health care to this population .',
  'Aging will be a serious social problem in the future .',
  'A serious social problem in a super-aged society is the rise in the number of elderly people who need long-term care ( LTC ) , which is mainly due to cerebrovascular disease , dementia , age-related frailty , falls and fractures , and joint disease .',
  'Shanghai has experienced rapid urbanization and has a serious housing aging problem .',
  'Aging populations are expanding worldwide , and the increasing requirement for nursing care has become a serious problem .',
  'Regression in the elderly is a serious problem that requires staff teamwork .',
  'Isolated death of elderly is recognized as a severe social problem in public health and it is an urgent requirement that a supportive community network be organized so that its occurrence is minimized .',
  'It is also expected to pose a serious problem in future societies composed of large numbers of elderly people .',
  'In connection with population aging and the huge variety of factors and conditions that can induce this condition , it is becoming a serious and growing problem .',
  "The issue of older adults ' care is becoming a serious concern in Japan , which has a rapidly aging population and a low birthrate .",
  'Those diseases constitute a serious health problem within the sickness absenteeism of workers over 40 .',
  'this reflects a serious concern about the staffing of the geriatric service .',
  'With the rising incidence of chronic diseases , and the increase of aging population has led to multimorbidity a serious public health problem .',
  'It is one of the most prevalent CV conditions worldwide in subjects > 65 years , estimated to increase greatly with the aging of the population , becoming a severe socioeconomic problem in the future .',
  "The new social and economic roles of senior 's age people are a serious problem that urgently needs to be resolved .",
  'Frailty in older adults is a serious problem because of various adverse health outcomes in many countries with aging populations , such as Japan .',
  'In Japan there is a serious problem that we will have to face and handle , which is the super aging of society around 2010 .',
  'Multimorbidity is increasingly being recognized as a serious public health concern .',
  'Thailand is becoming an aging society , this presenting as a serious problem situation especially regarding health .',
  'The combination of an aging population and a high incidence in geriatric patients constitute a serious potential public health concern .',
  'Loss of the only child is the most traumatic event for the parents , which is a serious and unique problem in Chinese society that deserves attention .',
  'Due to its course and incidence are a major cause of disability and impaired quality of life for seniors , as well as a serious economic problem in health care .',
  'The rapid growth of population aging makes providing adequate long-term care ( LTC ) services for the elderly a serious social dilemma in China .',
  'We conclude that HCAIs are a serious health problem in German nursing home residents .',
  'Ageism ( negative attitudes and behavior toward older adults ) is a serious social issue and is of growing concern as the population of older adults continues to increase .',
  'This condition is becoming a serious problem because of the increasing numbers of the aged population all over the world .'],
 'influenza': ['The inherent problem with current influenza vaccines is that they do not generate effective cross-protection against heterologous viral strains .',
  'Influenza is a serious public health concern worldwide , as it causes significant morbidity and mortality .',
  'The research advances on flavonoids showing anti-influenza activity and the efforts made by researchers and industries consolidate the interest on new alternatives for the therapy of an infectious disease that represents a serious public health problem throughout the world .',
  'Influenza A viruses ( IAVs ) have always remain a serious concern for the global economy and public health .',
  'Since 2003 , the highly pathogenic avian influenza ( HPAI ) H5N1 has become a serious problem in animals and an increasing threat to public health .',
  'Influenza virus infection is a serious problem in the elderly because of the high pneumonia complication rate and a significant increase in mortality .',
  'Influenza is a serious public health problem , since seasonal epidemics affect approximately 5 - 10 % of the population and thus give rise to a heavy social and healthcare burden .',
  'Influenza virus infections represent a serious public health problem worldwide , due to the rapid emergence of drug resistance .',
  'Influenza is a serious public health problem that causes severe illnesses and deaths for higher risk populations .',
  'Although gene exchange is not likely to occur freely , reassortment between the H5N1 highly pathogenic avian influenza virus ( HPAIV ) and currently circulating human viruses is a serious concern .',
  'Influenza A viruses ( IAVs ) represent a serious concern globally because they are capable of rapid spread and cause severe disease in humans and other animals .',
  'Influenza virus infections represent a serious public health problem causing contagious respiratory disease and substantial morbidity and mortality in humans , resulting in a considerable economic burden worldwide .',
  'Influenza virus is a serious health concern .',
  'Influenza is a serious public health problem that causes a contagious respiratory disease .',
  'Highly pathogenic avian influenza H5N1 remains a serious concern for both poultry and human health .',
  'Effective vaccination against influenza virus infection is a serious problem mainly due to antigenic variability of the virus .',
  'Globally , avian influenza ( AI ) is a serious problem in poultry farming .',
  'In addition , T cells play a major role in defending host against influenza virus infection , a serious medical problem with high morbidity and mortality in the elderly people .',
  'Influenza virus infections constitute a serious public health problem',
  'Avian influenza has become a serious concern from both veterinary and public health points of view .',
  'Seasonal influenza infection in hospitals is a serious problem , and infection prevention is important .',
  'Human infections with avian influenza viruses are a serious public health concern .',
  'Influenza infection and associated epidemics represent a serious public health problem .',
  'Any increase in beta-lactam-resistant Haemophilus influenzae is a serious problem in respiratory and otolaryngology medicine .',
  'Influenza is a serious problem for infants < 6 months of age , whose hospitalization rates for influenza and associated illness are comparable with rates in the elderly .',
  'Influenza virus infections represent a serious concern to public health , being characterized by high morbidity and significant mortality .',
  'Human influenza remains a serious public health problem .',
  'Influenza is a serious health problem worldwide .',
  'Influenza viruses remain a serious public health problem .',
  'Influenza remains a serious worldwide public health problem .',
  'Influenza is a serious public health problem that causes severe illnesses and deaths for higher risk populations .',
  'The emergence of a novel H7N9 avian influenza that infects humans is a serious cause for concern .',
  'Influenza remains a serious health problem , annually causing epidemics embracing up to 10 % of the population of the world , and at the periods of pandemics this number may rise 4- to 6-fold .',
  'Influenza A virus ( IAV ) infection is a serious public health problem not only in South East Asia but also in European and African countries .',
  'Influenza is a serious public health concern , resulting in morbidity , mortality and significant expense to healthcare systems worldwide .',
  'Planning for a severe influenza pandemic entails facing many substantive public health challenges , especially in the area of the distribution of insufficient supplies of materials and personnel .',
  'Influenza viral infection represents a serious public health problem that causes contagious respiratory disease , which is most effectively prevented through vaccination to reduce transmission and future infection .',
  'Respiratory infections caused by viruses such as influenza and coronavirus are a serious global problem due to their high infection rates and potential to spark pandemics , such as the current COVID-19 pandemic .',
  'The emergence of oseltamivir-resistant 2009 H1N1 influenza virus ( conferred by the H275Y substitution in NA ) during therapy or prophylaxis in immunocompromised patients is a serious concern .',
  'Influenza infection is a serious problem in institutions for the elderly and those with increased risk factors because of the high pneumonia complication rate and a significant increase in mortality .',
  'Pandemic influenza A ( H1N1 ) was a serious health problem during the winter of 2009 - 2010 in Turkey .',
  'Influenza , a vaccine preventable disease , is a serious global public health concern which results in a considerable burden on the healthcare system .',
  'As healthcare-associated influenza is a serious public health concern , this review examines legal and ethical arguments supporting mandatory influenza vaccination policies for healthcare personnel , implementation issues and evidence of effectiveness .',
  'Influenza remains a serious public-health problem worldwide .',
  'Since influenza encephalopathy in infants is a serious problem in Japan , we have to investigate the usefulness of the vaccine in this age group .',
  'Influenza viral infections represent a serious public health problem , with influenza virus causing a contagious respiratory disease which is most effectively prevented through vaccination .',
  'Influenza is a serious medical and social problem for humanity .',
  'The RNA virus influenza A is a serious public health problem , with epidemics resulting in more than 250 \u2009 000 deaths every year .',
  'Seasonal and pandemic influenza infections remain a serious public health concern .',
  'Influenza epidemics are a serious global public health and economic problem .',
  'Recurrence of highly pathogenic avian influenza ( HPAI ) virus subtype H7 in humans and poultry continues to be a serious concern to public health .',
  'Continuously evolving highly pathogenic influenza A viruses are a serious health concern which necessitates a coupling of theoretical and experimental approaches to predict the evolutionary trends of the influenza A virus , with a focus on the H5 subtype .',
  'Influenza is a serious economic concern due to the costly countermeasures it necessitates .',
  'Influenza virus infections pose a serious public health problem and vaccination is the most effective public health intervention against them .',
  'Currently , H5N1 influenza viruses remain a serious public health concern in Asia and now in Europe .',
  'Sporadic emergence of the highly pathogenic avian influenza ( HPAI ) H5N1 virus infection in humans is a serious concern because of the potential for a pandemic .',
  'Influenza is a deadly and costly public health problem .',
  'Influenza is an acute respiratory illness and has become a serious public health problem worldwide .',
  'Influenza A viruses cause major morbidity and represent a severe global health problem .',
  'The spread of H5 subtype highly pathogenic avian influenza ( HPAI ) viruses of the Gs/GD lineage by migratory waterfowl is a serious concern for animal and public health .',
  'Healthcare associated influenza is a serious public health problem that contributes to patient morbidity and mortality .',
  'Influenza , one of the oldest and most common infections , poses a serious health problem causing significant morbidity and mortality , and imposing substantial economic costs .',
  'Influenza is a serious health problem in Europe .',
  'Flu caused by influenza viruses , is a serious public health problem all over the world with its high morbidity and mortality .',
  'Influenza is a serious problem for infants < 6 months of age , whose hospitalization rates for influenza and associated illness are comparable with rates in the elderly .',
  'Influenza is a serious global public health problem and an economic burden .',
  'Influenza is one of the most common human respiratory diseases , and represents a serious public health concern .',
  'Epidemics of influenza occurring each year in Poland in winter are a serious health problem and bring underestimated financial losses .',
  'Influenza A virus ( IAV ) poses a severe threat to human health and is a major public health problem worldwide .',
  'Influenza virus infection is a serious public health problem in the world , and understanding the molecular mechanisms involved in viral replication is crucial .',
  'Influenza A virus induces severe respiratory tract infection and results in a serious global health problem .',
  'Recurrence of the highly pathogenic avian influenza virus subtype H5N1 in humans and poultry continues to be a serious public health concern .',
  'Influenza virus infections are a serious public health concern throughout the world .',
  'Influenza A viruses ( IAVs ) cause seasonal epidemics and occasional pandemics , representing a serious public health concern .',
  'H5N1 infection and the potential for spread from human to human continue to pose a severe public health concern .',
  'Influenza in aging presents a serious clinical problem .',
  'Outbreaks of avian , human and swine influenza are a serious concern for public health .',
  'Seasonal influenza is a serious problem leading to elevated mortality in octogenarian and nonagenarian patients admitted to a general hospital .',
  'More recently , a swine-origin influenza A ( H1N1 ) virus that is spreading via human-to-human transmission has become a serious public concern .',
  'Seasonal influenza has become a serious public health problem worldwide , and vaccination is recognized as the most effective preventative measure .',
  'Of several infections , influenza virus infection is considered a serious problem .',
  'Influenza is a serious public health problem and the ED is an important healthcare location to educate patients .',
  'Influenza represents a serious public health concern .',
  'Avian influenza ( AI ) currently poses a serious problem for poultry farming worldwide .',
  'Influenza constitutes a serious problem for healthcare and social services worldwide , owing to its pattern and the severity of its complications in some categories of subjects at risk , such as the elderly and immunocompromised individuals .',
  'Seasonal influenza has become a serious public health problem worldwide and vaccination is recognized as the most effective preventative measure .',
  'Influenza A virus ( IAV ) is a serious global health problem worldwide due to frequent and severe outbreaks .',
  'Seasonal influenza is a serious public health and societal problem due to its consequences resulting from absenteeism , hospitalizations , and deaths .',
  'Though influenza is a serious health problem for elderly people , their influenza vaccination rate remains low in Switzerland .',
  'Influenza is a highly contagious respiratory tract disease and is considered a serious community health problem .',
  'Secondary bacterial infections after influenza can be a serious problem , especially in young children and the elderly , yet the efficacy of current vaccines is limited .',
  'Influenza virus infections represent a serious public health and economic problem , which are most effectively prevented through vaccination .',
  'Influenza type A is considered as a severe public health concern .'],
 'infertility': ['The problem with this " gold standard " is that it builds on the misconception that fertility peaks with ovulation and that ovulation regularly occurs 24 to 48 hours after the LH surge .',
  'A serious problem with the latter assumption is that those spermatozoa lack DNA repair .',
  'A major problem faced with the genetic improvement of reproductive traits is that recording the time for an animal to reach sexual maturity is costly .',
  'A study has suggested that one drawback of ICSI is that if these embryos are cryopreserved they have lower implantation rates after thawing and transfer as compared to other frozen embryos derived from conventional oocyte insemination .',
  'A serious drawback of the treatment is that a significant proportion of men do not reach azoospermia or severe oligozoospermia , commensurate with contraceptive efficacy .',
  'Male-factor infertility presents a vexing problem for many reproductively active couples .',
  'Male infertility is a serious social problem in modern society .',
  'A serious year-round fertility problem on a commercial piggery was investigated .',
  'Infertility is a serious public health problem worldwide .',
  'Male infertility is a serious diagnostic problem and in many cases the exact cause of failure to reproduce remains unknown .',
  'Infertility is a devastating problem around the world , particularly in the high fertility context of sub-Saharan Africa .',
  'Procreation of couples where the spouse is seropositive poses a serious ethical social and epidemiological problem .',
  'Sexual precocity is a serious problem because of genetic retrogression , which has negative effects on product quality and dramatically affects price .',
  'The patient who has gonadotrophin-resistant ovaries and who requires ovulation induction or superovulation for IVF presents a serious problem .',
  'Owing to its association with infertility , EjD is a serious concern , particularly in men of reproductive age .',
  'Recent evidence on child mortality and fertility trends in the community known as Karimpur in the north Indian state of Uttar Pradesh presents a troubling puzzle : the female children of the poor are now dying at a much more rapid rate than their brothers .',
  'The quality of injectable uterotonics in three contrasting districts in Ghana is a serious problem .',
  'Male infertility is a vexing yet common problem for men all over the world .',
  'Our hope is that with increasing experience with microinjection , in the near future , this type of infertility will not remain a serious problem .',
  'Fertilization failure is a serious problem in human in vitro fertilization ( IVF ) programs and deserves further investigation and management .',
  'Declining reproductive performance is a serious breeding concern in many countries .',
  'Male infertility is a devastating problem that affects many couples worldwide .',
  'Male factor Infertility is a devastating problem from which a notable percentage of couples suffer .',
  "Infertility is a serious problem in a couple 's life that affects their marriage relationships .",
  'Infertility is a serious social problem in advanced nations , with male factor in half of all cases of infertility .',
  'Infertility is a serious social problem in advanced nations today .',
  'Infertility is a severe public health problem worldwide that prevails up to 15 % in reproductive-age couples , and male infertility accounts for half of total infertility .',
  'Testicular torsion is a serious problem in male children and , if not treated at the right time , can lead to subfertility and infertility .',
  'There is an urgent need to recognize infertility as a serious reproductive health problem and to put infertility care on the public health agenda .',
  'Pulse and chase BrdU labeling of early chick embryos represents a serious technical problem due to the hindrance of removing unincorporated BrdU after the pulse .',
  'Infertility can be a devastating problem for a couple desperate to conceive .',
  'Male infertility is a serious problem in patients on hemodialysis .',
  'In Turkey , the rate of consanguineous marriage is quite high ( 22 - 24 \xa0 % ) and as a result , the incidence of autosomal recessive diseases and congenital anomalies is also very high and gives rise to a serious public health problem .',
  'Despite advances in Assisted Reproductive Technologies , infertility has remained a serious problem .',
  'Total asthenozoospermia is a severe problem , as only a micromanipulation technique can assist the couple , and even then fertilization and pregnancy rates are very low .',
  'As various oocyte manipulations employed in assisted reproductive technology are time consuming , post-ovulatory aging is a serious problem to overcome in reproductive medicine or ova research .',
  'Achieving ejaculation was a serious problem   for the patients in whom the lowest increases in testosterone and 5 alpha-DHT levels were observed after HCG stimulation .',
  'Significant embryo loss remains a serious problem in pig production .',
  'Variations in embryo production between individual oocyte donors represent a serious problem in cattle production , when implementing ovum pick-up ( OPU ) and in \xa0 vitro maturation ( IVM ) of oocytes .',
  'However , in a related herd infertility has become a serious problem .',
  'Surrogacy in Israel is restricted to couples with a serious infertility problem .',
  'Infertility is a serious but entirely neglected public health problem in resource-poor countries .',
  'Although aneuploidy is a serious human health problem , the experimental methodology devised until now to study the mechanisms involved in the induction of aneuploidy and for the screening of aneuploidy-inducing agents has not been so much employed to have the necessary validation .',
  'Infertility because of testicular damage is a distressing problem for survivors of cancer chemotherapy .',
  'Male infertility is a serious problem in an increasing number of couples .',
  'One bull was removed from the experiment due to a severe breeding problem .',
  'Although infertility is a serious concern in survivors of pediatric cancers , little is known about the influence of the degree of sexual maturation at the time of irradiation on spermatogenic recovery after treatment .',
  'We conclude that competition for resources is a serious problem in aging germ lines , and that apoptosis helps alleviate this problem .',
  'This paper examines how people account for health-seeking behaviour regarding infertility in developing countries , where infertility is a serious problem .',
  'Ambiguous sex has a great phenotypic variability and is a serious medical and social problem .',
  'Nevertheless , as this is an iatrogenic complication of a non-vital treatment with a potentially fatal outcome , the syndrome remains a serious problem for specialists dealing with infertility .',
  'The objective of this study was retrospectively to evaluate both in-vitro fertilization ( IVF ) and non-IVF cycles in which the male partner had been taking calcium channel blockers , either to confirm or refute previous data from another centre , suggesting that these drugs cause a severe but reversible subfertility problem in the male .',
  'In the present times when newer delivery systems of contraceptive agents and menstrual regulation procedures are increasingly used for fertility regulation , it is inevitable that confirmation of early pregnancy poses a severe problem .',
  'Infertility has recently been construed to be a serious problem in sub-Saharan Africa .',
  'Thus , the zebrafish egg proteome is clearly linked to embryo developmental potential , a phenomenon that begs further investigation to elucidate the root causes of poor egg quality , presently a serious and intractable problem in livestock and human reproductive medicine .',
  'Despite the advances in male infertility microsurgery in China , the lack of standardized and well-organized training programs for male infertility microsurgery remains a serious problem affecting its development .',
  'Reproductive dysfunction and malignancies related to the male gender represent a serious health concern , whose incidence has significantly risen over the past years .',
  'Aneuploidy represents a serious problem for human health .',
  'Male infertility is a serious problem all over the world .',
  'There is an increasing awareness that infertility in Sub-Saharan Africa constitutes a severe social and public health problem .',
  'This becomes a serious problem for couples who seek to have children but are limited by unsuccessful attempts to become pregnant and a technology that is behind in mimicking the in vivo environment that would enhance gamete interaction and embryo development .',
  'Male dog infertility may represent a serious concern in the canine breeding market .',
  'Sterility is a severe social problem .',
  'The routine application of IVF may be a consequence of these failings and should this form of treatment be shown to have been unnecessary or , especially , should it result in a clinical disaster , then a serious medico-legal problem may result .',
  'Moreover , results also help to understand a serious concern about the presence of CPA in foods as a potential risk factor in male-related infertility .',
  'Infertility must be considered as a serious reproductive health problem in Mozambique .',
  'Ovarial hyperstimulation syndrome ( OHSS ) represents a serious problem encountered during in vitro fertilization ( IVF ) .',
  "The optimal timing of intracytoplasmic sperm injection ( ICSI ) is of a serious concern for fertility programs because untimely sperm entry diminishes the egg 's developmental competence .",
  'There is a serious problem with the reduction of male reproductive performance of the livestock in the world .',
  'In conclusion , decreased fertility may be a serious problem Botox ® injections could cause .',
  'Sterility is a serious problem that can affect all bionts .',
  'This paper challenges the construct that infertility is not a serious problem in resource-constrained settings and argues that there is a need for infertility care , including affordable assisted reproduction treatment , in these settings .',
  'Infertility is common , a serious medical problem in both advanced and underdeveloped countries .',
  'Aneuploidy also represents a serious problem in procedures utilizing mammalian gametes and early embryos in vitro .',
  'In addition , men with subfertility may have a serious underlying medical or genetic problem that could also be overlooked .',
  'Infertility is a serious social problem in advanced nations , with male factor infertility accounting for approximately half of all cases of infertility .',
  'Disorders of sex development ( DSD ) are a serious health problem in dogs .',
  'Recently , gradual decline in human sperm production has become a serious worldwide concern because it leads to increased rates of infertility .',
  'Male infertility is a serious problem , and its prevalence has been increasing .',
  'Infertility is a serious health problem that affects the individual , her/his family , and the community .',
  'Infertility after hemopoietic stem cell transplantation ( HST ) is a serious problem for young patients .',
  'Infertility is a serious problem for those who suffer .'],
 'undernutrition': ["The problem with poor ; QoL , nutritional care and academic performance ( AP ) of the OVC is that it sets the foundation for their adults ' life .",
  'Malnutrition remains a serious public health problem , and thus , the development of novel treatment methods is highly essential .',
  'Childhood malnutrition is still a serious worldwide public health problem and its consequences are particularly severe when present during early life .',
  'Malnutrition is a serious problem , and malabsorption of nutrients is believed to be partially responsible for its prevalence .',
  'Malnutrition is a serious problem among children in developing countries .',
  'Though Ethiopia has implemented different nutritional interventions , childhood stunting on which literature is limited continues as a severe public health problem .',
  'Undernutrition is a serious global problem that contributes to increased child morbidity and mortality , impaired neurocognitive development , and decreased educational and economic attainment .',
  'However , the prevalence of undernutrition remains a serious problem .',
  'Malnutrition is a serious public health problem in Cameroon .',
  'This study indicates that undernutrition is a serious problem among rural Malawians aged 45 - 75 years .',
  'Malnutrition is a serious public health problem that affects approximately one third of all children .',
  'Inadequate daily intake of energy and nutrients of most of the children , in combination with parasitic infections , still common in rural northeast Thailand , was shown to result in a serious public health problem .',
  'A low prevalence of children with a weight-for-age Z-score below -2 was found , indicating that at the time of the survey protein-energy malnutrition was not a serious problem for this age group .',
  'Severe acute malnutrition ( SAM ) remains a serious public health concern in low- and middle-income countries .',
  'Deficiency/disability in children is still a serious medical , social and human problem .',
  'The results indicate that malnutrition is a serious public health problem in the studied regions .',
  'Child undernutrition is a serious public health problem in many low- and middle-income countries .',
  'Malnutrition remains a serious concern in Rwanda , particularly among children under-5 years .',
  'Introduction : Child malnutrition remains a serious public health problem in Honduras , with a national prevalence according to the World Health',
  'Child wasting is a severe public health problem in the predominantly rural population of Ethiopia : A community based cross-sectional study .',
  'The severity of hunger in mountain and hill districts of Mid- and Far-Western Development Regions is a serious concern .',
  'Malnutrition remains a serious health problem in Cambodia with over 10 % of children less than five years of age suffering from acute malnutrition .',
  'In Ethiopia , child undernutrition continues to be a serious public health problem .',
  'However malnutrition in poor areas is still a serious problem .',
  'Childhood malnutrition and growth faltering is a serious concern in Nepal .',
  'These results show that malnutrition is still a serious public health problem in Kenya and requires urgent attention .',
  'Malnutrition among children is a serious public health problem in the aftermath of any natural disaster .',
  'Food insecurity remains highly prevalent in developing countries and over the past two decades it has increasingly been recognized as a serious public health problem , including in Ethiopia .',
  'A body of evidences showed that adolescent undernutrition is a serious public health problem in developing countries including Ethiopia .',
  'Malnutrition is a severe problem of public health over all the world , particularly in Latin America .',
  'Although globally the numbers of children diagnosed with failure to thrive ( FTT ) have decreased , FTT is still a serious pediatric problem .',
  'Maternal undernutrition persists as a serious problem in Ethiopia .',
  'Poor nutritional status of women has been a serious problem in Ethiopia .',
  'Malnutrition is a serious public health problem , particularly in developing countries , linked to a substantial increase in the risk of mortality and morbidity .',
  'Mortality of children with severe acute malnutrition ( SAM ) is a devastating problem in Ethiopia .',
  'Protein-energy malnutrition ( PEM ) is a serious health problem among young children in Bangladesh .',
  'The burden of food insecurity and malnutrition is a severe problem experienced by many poor households and children under the age of five are at high risk .',
  'Nutritional deficiencies in children represents a serious public health problem in Bom Jesus , Angola .',
  'Malnutrition is a serious public health problem . The humanitarian community needs to adopt alternative strategies to improve food security and the nutrition status in Yemen .',
  'Malnutrition is a serious public health problem that has been linked to increase risk of morbidity and mortality in slums of Dhaka city and where the prevalence of malnutrition is very high .',
  'Malnutrition and bacterial gastrointestinal and respiratory infections represent a serious public health problem .',
  'Undernutrition is a serious health problem and highly prevalent in developing countries .',
  'Micronutrient malnutrition is a serious public health problem in developing countries , including Sri Lanka .',
  'Despite the failures of numerous diagnostic methods-even the definition of malnutrition defied consensus-health authorities remained convinced that malnutrition was a serious and widespread problem .',
  'Childhood undernutrition is a serious public health problem in South Africa .',
  'The ENAL 96 shows that malnutrition is still a severe national problem which has not improved in the last 22 years .',
  'Childhood overnutrition is a serious public health problem , with consequences that extend into adulthood .',
  'Malnutrition in children under 5 years of age ( U5s ) is a serious public health problem in low- and middle-income countries including Bangladesh .',
  'The improper relations between Fe and energy content in food rations of women at the reproductive age were found to deserve a serious concern .',
  'However , published estimates suggest that malnutrition continues to be a serious public health problem .',
  'The study concludes that maternal malnutrition is a serious problem in the study area and that there are contextual risk factors that could be addressed to partially tackle the problem .',
  'Insufficient intake of fresh fruits , vegetables , and dairy products among children is a serious nutrition-related concern .',
  'Childhood malnutrition is a serious public health problem in Yemen .',
  'Malnutrition among the indigenous early childhood population is still currently a serious public health problem , and given that no specific studies affording the possibility of knowing the nutritional condition of this population , the question was posed of identifying the prevalence of malnutrition among the indigenous population of Mexico by means of the 1999 National Nutrition Survey .',
  'The double burden of malnutrition also affects the poor , which is a serious problem in Asia , as it has the largest number of poor subsisting on less than $ 1/day .'],
 'platelet': ['A major problem associated with platelet storage containers is that some platelet units show a dramatic fall in pH , especially above certain platelet contents .',
  'An unresolved problem with clinical use of antiplatelet therapy is that a significant number of individuals either still get thrombosis or run the risk of life-threatening bleeding .',
  'A potential problem with the perioperative use of NSAIDS is that they inhibit platelet aggregation .',
  'Unfractionated heparin is often used to prevent thrombosis in microvascular surgery , but a major drawback of heparin therapy is increased bleeding .',
  'A major drawback of fibrinolysis is the activation of platelets leading to a high rate of re-occlusion .',
  'A higher incidence of bleeding because of its anticoagulant function has been found to be a major drawback of APC as an effective anti-inflammatory drug .',
  'The absence of clots and deposits on the heparin coated IAB suggests a promising role of such devices in circumventing the tendency of clot formation on deflated balloons while avoiding the drawback of systemic anticoagulation .',
  'A major drawback of the use of these PCs is the progressive increase of P-selectin-positive platelets during storage .',
  'Acute arterial closure either from thrombosis or embolization often is a serious and potentially life-threatening clinical problem .',
  'Heparin-induced thrombocytopenia and thrombosis ( white clot syndrome ) is a devastating clinical problem as illustrated by the case presented .',
  'With increased use of anticoagulant agents , femoral neuropathy subsequent to spontaneous hemorrhage within the ileo-psoas muscle has become a serious and more frequent clinical problem .',
  'Pseudoprolongation of activated partial thromboplastin time ( APTT ) is a serious problem in anticoagulation therapy for patients with high hematocrit , such as cyanotic congenital heart diseases .',
  'Persistent platelet activation poses a serious problem among patients with acute coronary syndromes ( ACS ) and those who have undergone percutaneous coronary intervention ( PCI ) , placing them at risk for ischemic events and subacute stent thrombosis .',
  'Clopidogrel ineffectiveness is a serious problem in antiplatelet therapy .',
  'Heparin-associated thrombocytopenia and thrombosis : a serious clinical problem and potential solution .',
  'Although the treatment outcome is dramatically improved by all-trans retinoic acid ( ATRA ) , life-threatening bleeding from enhanced fibrinolytic-type disseminated intravascular coagulation ( DIC ) remains a serious clinical problem , and a standard treatment has not been established .',
  'Any hemorrhage in a hemophilic patient must be regarded as a serious problem .',
  'Therefore , we should note that acute bleeding is a serious problem that requires adequate complex infusion-transfusion therapy , circulating blood volume restoration , microcirculation improvement and prevention of all reasons of bleeding .',
  'Alloimmune platelet refractoriness ( alloPR ) among actively bleeding surgical patients with thrombocytopenia represents a life-threatening problem .',
  'Menorrhagia was a serious problem necessitating repeated transfusions and hormonal therapy .',
  '[ Circulating heparinoid anticoagulant ( antithrombin II ) . Report of a fatal case and review of the problem ] .',
  'However , there are clearly a number of inherited or acquired pathologies where hyperfibrinolysis is a serious , potentially life-threatening problem and a number of antifibrinolytc drugs are available to treat hyperfibrinolysis .',
  'Resistance to antithrombotic drugs is a serious problem because these patients are at a higher risk of myocardial infarction , stroke and cardiovascular death .',
  'Massive bleeding that can not be controlled by the usual means , such as transfusion , is a serious medical problem with high associated mortality .',
  'Thrombotic thromboctopenic purpura is a rare multisystemic life threatening disease the treatment of which is still a serious problem .',
  'Nevertheless , the concurrent increased risk of bleeding while using anticoagulants is a severe problem and negatively impacts upon clinical outcome .',
  'Despite significant benefits demonstrated with combination antiplatelet treatment in large clinical trials , the occurrence of adverse ischemic events , including stent thrombosis , remains a serious clinical problem .',
  'Introduction of anticoagulant treatment led to a marked drop of these complications , while haemorrhage became a serious problem in their care .',
  'Inadequate responses to platelet transfusions ( i.e. , platelet transfusion refractoriness [ PLT refractoriness ] ) are a serious problem .',
  'Although the antithrombotic potential of oral anticoagulants is undisputed , bleeding complications constitute a serious problem .',
  'Heparin-induced thrombocytopenia caused by heparin-platelet factor 4 antibodies ( HPF4-As ) , however , remains a serious concern .',
  'The management of life-threatening bleeding in patients who are receiving direct oral anticoagulants ( DOACs ) is a serious medical concern .',
  'In cases where extensive perioperative anticoagulation is mandatory , bleeding at the puncture site may be a serious problem and can be controlled more effectively through an open surgical approach than by percutaneous maneuvers .',
  'Thrombocytopenia is a serious clinical problem in several different clinical settings .',
  'While warfarin is the most commonly prescribed medication to prevent thromboembolic disorders , the risk of adverse drug reactions ( ADR ) poses a serious concern .',
  'For many years a serious unresolved problem was that the clotting time was normal even in severe thrombocytopenia .',
  'Since HPTs are frequently given therapeutically to patients with ARDS , a serious concern clinically has been the possibility that platelet transfusions might worsen pulmonary function in such patients .',
  'Surgical correction or low molecular weight heparin is treatment of choice , but for a severe bleeding problem due to excessive fibrinolysis , para-aminomethylbenzoic acid would be a simple and effective therapeutic approach .',
  'HES-induced coagulopathy could be a serious problem in PLIF which involves continuous bone bleeding and oozing .',
  'Heparin-associated thrombocytopenia is a serious medical problem , especially when the patient requires continued anticoagulation .',
  'The bleeding issue increases morbidity and mortality , a serious problem in daily medical practice .',
  'Heparin-induced thrombocytopenia with thrombotic complications is a serious clinical problem .',
  'Heparin-associated thrombocytopenia and thrombosis : a serious clinical problem and potential solution .',
  'The occurrence of bleeding in trauma patients is a life-threatening problem which can be explained by different mechanisms .',
  'Despite significant benefits reported with dual antiplatelet treatment in major clinical trials , the occurrence of adverse ischemic events , including stent thrombosis , remains a serious clinical problem .',
  'Intraabdominal bleeding is a serious surgical problem , particularly in elderly patients following an anticoagulant therapy .',
  'Bleeding was more common after treatment with streptokinase than with heparin , but was not a serious problem in any patient .',
  'Mean platelet volume ( MPV ) may be a useful parameter for inflammatory conditions , in differentiating between non-specific abdominal pain ( NSAP ) and conditions requiring surgery , or early diagnosis of abdominal pain as a serious problem for emergency services .',
  'Hemorrhage is no longer a fearsome problem .',
  'Of particular interest is the use of FloSeal ( collagen and thrombin gelatine ) to treat bleeding from retroneural arterial vessels , wich has often been seen to pose a serious problem for the surgeon .',
  'Anticoagulants are associated with a severe side effect , bleeding , which makes emergency neutralization an important concern .',
  'Platelet refractoriness ( unsatisfactory post-transfusion platelet increment ) is a severe problem that impairs the treatment of oncohematologic patients and is not routinely investigated in most Brazilian services .',
  'Drug-Induced Thrombocytopenia : Is it a Serious Concern for Glycoprotein IIb/IIIa Receptor Inhibitors ?',
  'Hemostasis after CPB is still a vexing problem , and the addition of antiplatelet medication to the platelet defect already incurred during CPB has led to hemorrhagic complications in cardiac surgery .'],
 'thrombocytopenia': ['A major problem associated with platelet storage containers is that some platelet units show a dramatic fall in pH , especially above certain platelet contents .',
  'An unresolved problem with clinical use of antiplatelet therapy is that a significant number of individuals either still get thrombosis or run the risk of life-threatening bleeding .',
  'A potential problem with the perioperative use of NSAIDS is that they inhibit platelet aggregation .',
  'Unfractionated heparin is often used to prevent thrombosis in microvascular surgery , but a major drawback of heparin therapy is increased bleeding .',
  'A major drawback of fibrinolysis is the activation of platelets leading to a high rate of re-occlusion .',
  'A higher incidence of bleeding because of its anticoagulant function has been found to be a major drawback of APC as an effective anti-inflammatory drug .',
  'The absence of clots and deposits on the heparin coated IAB suggests a promising role of such devices in circumventing the tendency of clot formation on deflated balloons while avoiding the drawback of systemic anticoagulation .',
  'A major drawback of the use of these PCs is the progressive increase of P-selectin-positive platelets during storage .',
  'Acute arterial closure either from thrombosis or embolization often is a serious and potentially life-threatening clinical problem .',
  'Heparin-induced thrombocytopenia and thrombosis ( white clot syndrome ) is a devastating clinical problem as illustrated by the case presented .',
  'With increased use of anticoagulant agents , femoral neuropathy subsequent to spontaneous hemorrhage within the ileo-psoas muscle has become a serious and more frequent clinical problem .',
  'Pseudoprolongation of activated partial thromboplastin time ( APTT ) is a serious problem in anticoagulation therapy for patients with high hematocrit , such as cyanotic congenital heart diseases .',
  'Persistent platelet activation poses a serious problem among patients with acute coronary syndromes ( ACS ) and those who have undergone percutaneous coronary intervention ( PCI ) , placing them at risk for ischemic events and subacute stent thrombosis .',
  'Clopidogrel ineffectiveness is a serious problem in antiplatelet therapy .',
  'Heparin-associated thrombocytopenia and thrombosis : a serious clinical problem and potential solution .',
  'Although the treatment outcome is dramatically improved by all-trans retinoic acid ( ATRA ) , life-threatening bleeding from enhanced fibrinolytic-type disseminated intravascular coagulation ( DIC ) remains a serious clinical problem , and a standard treatment has not been established .',
  'Any hemorrhage in a hemophilic patient must be regarded as a serious problem .',
  'Therefore , we should note that acute bleeding is a serious problem that requires adequate complex infusion-transfusion therapy , circulating blood volume restoration , microcirculation improvement and prevention of all reasons of bleeding .',
  'Alloimmune platelet refractoriness ( alloPR ) among actively bleeding surgical patients with thrombocytopenia represents a life-threatening problem .',
  'Menorrhagia was a serious problem necessitating repeated transfusions and hormonal therapy .',
  '[ Circulating heparinoid anticoagulant ( antithrombin II ) . Report of a fatal case and review of the problem ] .',
  'However , there are clearly a number of inherited or acquired pathologies where hyperfibrinolysis is a serious , potentially life-threatening problem and a number of antifibrinolytc drugs are available to treat hyperfibrinolysis .',
  'Resistance to antithrombotic drugs is a serious problem because these patients are at a higher risk of myocardial infarction , stroke and cardiovascular death .',
  'Massive bleeding that can not be controlled by the usual means , such as transfusion , is a serious medical problem with high associated mortality .',
  'Thrombotic thromboctopenic purpura is a rare multisystemic life threatening disease the treatment of which is still a serious problem .',
  'Nevertheless , the concurrent increased risk of bleeding while using anticoagulants is a severe problem and negatively impacts upon clinical outcome .',
  'Despite significant benefits demonstrated with combination antiplatelet treatment in large clinical trials , the occurrence of adverse ischemic events , including stent thrombosis , remains a serious clinical problem .',
  'Introduction of anticoagulant treatment led to a marked drop of these complications , while haemorrhage became a serious problem in their care .',
  'Inadequate responses to platelet transfusions ( i.e. , platelet transfusion refractoriness [ PLT refractoriness ] ) are a serious problem .',
  'Although the antithrombotic potential of oral anticoagulants is undisputed , bleeding complications constitute a serious problem .',
  'Heparin-induced thrombocytopenia caused by heparin-platelet factor 4 antibodies ( HPF4-As ) , however , remains a serious concern .',
  'The management of life-threatening bleeding in patients who are receiving direct oral anticoagulants ( DOACs ) is a serious medical concern .',
  'In cases where extensive perioperative anticoagulation is mandatory , bleeding at the puncture site may be a serious problem and can be controlled more effectively through an open surgical approach than by percutaneous maneuvers .',
  'Thrombocytopenia is a serious clinical problem in several different clinical settings .',
  'While warfarin is the most commonly prescribed medication to prevent thromboembolic disorders , the risk of adverse drug reactions ( ADR ) poses a serious concern .',
  'For many years a serious unresolved problem was that the clotting time was normal even in severe thrombocytopenia .',
  'Since HPTs are frequently given therapeutically to patients with ARDS , a serious concern clinically has been the possibility that platelet transfusions might worsen pulmonary function in such patients .',
  'Surgical correction or low molecular weight heparin is treatment of choice , but for a severe bleeding problem due to excessive fibrinolysis , para-aminomethylbenzoic acid would be a simple and effective therapeutic approach .',
  'HES-induced coagulopathy could be a serious problem in PLIF which involves continuous bone bleeding and oozing .',
  'Heparin-associated thrombocytopenia is a serious medical problem , especially when the patient requires continued anticoagulation .',
  'The bleeding issue increases morbidity and mortality , a serious problem in daily medical practice .',
  'Heparin-induced thrombocytopenia with thrombotic complications is a serious clinical problem .',
  'Heparin-associated thrombocytopenia and thrombosis : a serious clinical problem and potential solution .',
  'The occurrence of bleeding in trauma patients is a life-threatening problem which can be explained by different mechanisms .',
  'Despite significant benefits reported with dual antiplatelet treatment in major clinical trials , the occurrence of adverse ischemic events , including stent thrombosis , remains a serious clinical problem .',
  'Intraabdominal bleeding is a serious surgical problem , particularly in elderly patients following an anticoagulant therapy .',
  'Bleeding was more common after treatment with streptokinase than with heparin , but was not a serious problem in any patient .',
  'Mean platelet volume ( MPV ) may be a useful parameter for inflammatory conditions , in differentiating between non-specific abdominal pain ( NSAP ) and conditions requiring surgery , or early diagnosis of abdominal pain as a serious problem for emergency services .',
  'Hemorrhage is no longer a fearsome problem .',
  'Of particular interest is the use of FloSeal ( collagen and thrombin gelatine ) to treat bleeding from retroneural arterial vessels , wich has often been seen to pose a serious problem for the surgeon .',
  'Anticoagulants are associated with a severe side effect , bleeding , which makes emergency neutralization an important concern .',
  'Platelet refractoriness ( unsatisfactory post-transfusion platelet increment ) is a severe problem that impairs the treatment of oncohematologic patients and is not routinely investigated in most Brazilian services .',
  'Drug-Induced Thrombocytopenia : Is it a Serious Concern for Glycoprotein IIb/IIIa Receptor Inhibitors ?',
  'Hemostasis after CPB is still a vexing problem , and the addition of antiplatelet medication to the platelet defect already incurred during CPB has led to hemorrhagic complications in cardiac surgery .'],
 'spectrometry': ['However , a limitation of current LC-MS/MS approaches , which typically employ electrospray ionization with analysis of positive ions , is that no single survey scan exhibits broad utility in the detection of unknown GSH adducts , since different structural classes of conjugate ( aromatic , benzylic , aliphatic , thioester , etc . ) behave differently upon collision-induced dissociation ( CID ) of the respective [ M + H]+ parent ions .',
  'Although a major drawback of NMR is its difficulty in studying the dynamical ordering of larger biomolecular systems , current technologies have achieved considerable success in the structural analysis of substantially large proteins and biomolecular complexes over 1MDa and have characterised a wide range of timescales across which biomolecular motion exists .',
  'Single-photon ionization mass spectrometry ( SPI-MS ) is a versatile and powerful analytical technique for online and real-time analysis of organic species ; however , it is confronted with an intrinsic drawback of lacking structural information on the investigated molecules , let alone differentiation of isobaric compounds .',
  'A major drawback of the step response technique is its high susceptibility to thermal drifts and noise which directly determine the minimum detectable binding mass .',
  'A major drawback of liquid chromatography-mass spectrometry is that no standard spectral libraries such as NIST and Wiley for GC-MS are available to facilitate the identification of unknown compounds .',
  'While as a result of the extensive sample preparation ( analyte isolation ) preceding TIMS and the " softer " ionization in vacuum , spectral interferences only seldom occur with this technique , their occurrence is recognized to be the most important drawback of ICPMS .',
  'The drift in sensitivity due to carbon deposition on the sampling cone , skimmer cone and ion lenses has been a serious problem in gas chromatography/inductively coupled plasma mass spectrometry ( GC/ICP-MS ) .',
  'When the mass spectra of biological samples ( proteins , peptides , and so on ) are obtained routinely by matrix-assisted laser desorption/ionization mass spectrometry ( MALDI-MS ) , a serious problem is the reduction of the ionization efficiency by impurities , such as buffer salts and detergents .',
  'Free-energy calculations for high-dimensional systems , such as peptides or proteins , always suffer from a serious sampling problem in a huge conformational space .',
  'The signal-to-noise ratio , which becomes a serious problem in field desorption mass spectrometry at low accelerating voltages , and the low instrument sensitivity were improved considerably by our use of a method of adding scans with low total ion currents obtained over a longer desorption time .',
  'At the current stage , multidimensional NMR spectra that do not have a serious dynamic range problem , such as triple resonance experiments used for sequential assignments , are readily recorded and faithfully reconstructed using non-uniform sampling .',
  'The heterogeneity of ion signals is a severe problem in MALDI , which results in poor data reproducibility and makes MALDI unsuitable for quantitative analysis .',
  'Ionization suppression is a serious problem in liquid chromatography/mass spectrometry-based metabolomics , and stable isotope dilution-based comparative quantification is one of the most important methods of overcoming this problem .',
  'However , this approach found little use in the studies of disordered proteins , where the sampling of vast conformational space presents a serious problem .'],
 'ionization': ['However , a limitation of current LC-MS/MS approaches , which typically employ electrospray ionization with analysis of positive ions , is that no single survey scan exhibits broad utility in the detection of unknown GSH adducts , since different structural classes of conjugate ( aromatic , benzylic , aliphatic , thioester , etc . ) behave differently upon collision-induced dissociation ( CID ) of the respective [ M + H]+ parent ions .',
  'Although a major drawback of NMR is its difficulty in studying the dynamical ordering of larger biomolecular systems , current technologies have achieved considerable success in the structural analysis of substantially large proteins and biomolecular complexes over 1MDa and have characterised a wide range of timescales across which biomolecular motion exists .',
  'Single-photon ionization mass spectrometry ( SPI-MS ) is a versatile and powerful analytical technique for online and real-time analysis of organic species ; however , it is confronted with an intrinsic drawback of lacking structural information on the investigated molecules , let alone differentiation of isobaric compounds .',
  'A major drawback of the step response technique is its high susceptibility to thermal drifts and noise which directly determine the minimum detectable binding mass .',
  'A major drawback of liquid chromatography-mass spectrometry is that no standard spectral libraries such as NIST and Wiley for GC-MS are available to facilitate the identification of unknown compounds .',
  'While as a result of the extensive sample preparation ( analyte isolation ) preceding TIMS and the " softer " ionization in vacuum , spectral interferences only seldom occur with this technique , their occurrence is recognized to be the most important drawback of ICPMS .',
  'The drift in sensitivity due to carbon deposition on the sampling cone , skimmer cone and ion lenses has been a serious problem in gas chromatography/inductively coupled plasma mass spectrometry ( GC/ICP-MS ) .',
  'When the mass spectra of biological samples ( proteins , peptides , and so on ) are obtained routinely by matrix-assisted laser desorption/ionization mass spectrometry ( MALDI-MS ) , a serious problem is the reduction of the ionization efficiency by impurities , such as buffer salts and detergents .',
  'Free-energy calculations for high-dimensional systems , such as peptides or proteins , always suffer from a serious sampling problem in a huge conformational space .',
  'The signal-to-noise ratio , which becomes a serious problem in field desorption mass spectrometry at low accelerating voltages , and the low instrument sensitivity were improved considerably by our use of a method of adding scans with low total ion currents obtained over a longer desorption time .',
  'At the current stage , multidimensional NMR spectra that do not have a serious dynamic range problem , such as triple resonance experiments used for sequential assignments , are readily recorded and faithfully reconstructed using non-uniform sampling .',
  'The heterogeneity of ion signals is a severe problem in MALDI , which results in poor data reproducibility and makes MALDI unsuitable for quantitative analysis .',
  'Ionization suppression is a serious problem in liquid chromatography/mass spectrometry-based metabolomics , and stable isotope dilution-based comparative quantification is one of the most important methods of overcoming this problem .',
  'However , this approach found little use in the studies of disordered proteins , where the sampling of vast conformational space presents a serious problem .'],
 'coinfection': ['The problem with the emergence of HIV-associated tuberculosis ( which usually occurs in young adults ) is that attention has been diverted away from the fact that , in the developed world , the elderly represent the biggest pool of tubercular disease and therefore the greatest pool of infection within the community .',
  'The treatment regimen of HIV-TB coinfection is associated with a major drawback of low therapeutic concentration of drugs in lungs .',
  'Co-infection of tuberculosis ( TB ) and HIV is a serious problem in most developing countries and in industrialized countries , co-infection of TB and HIV is seen mainly among migrant population .',
  'The pandemic spread of tuberculosis ( TB ) and human immunodeficiency virus ( HIV ) represents a serious world problem .',
  'To this end , reactivation of latent tuberculosis infection represents a serious concern of anti-TNFalpha antibody therapy .',
  'Reactivation tuberculosis ( TB ) is a serious problem in immunocompromised individuals , especially those with human immunodeficiency virus ( HIV ) coinfection .',
  'The interaction between HIV and M. tuberculosis infection poses a serious health problem which will result in a major increase in disease , death and health care service needs in many countries .',
  'HIV-associated TB is a serious public health problem in Myanmar .',
  'Tuberculosis associated with human immunodeficiency virus ( HIV ) infection continues to represent a serious medical and public health problem .',
  'The co-infection of tuberculosis ( TB ) and human immunodeficiency virus ( HIV ) continue to be a severe problem in the European region .',
  'Coinfection with Mycobacterium tuberculosis and human immunodeficiency virus ( HIV ) is a serious problem , particularly in developing countries .',
  'The situation of tuberculosis ( TB ) is being modified by the human immunodeficiency virus ( HIV ) , which is increasing the occurrence of new cases and the generation of drug resistant strains , affecting not only the people infected with HIV , but also their close contacts and the general population , conforming a serious public health concern .'],
 'women': ["Violence against women , especially by intimate partners , is a serious public health problem that is associated with physical , reproductive and mental health consequences . Even though most societies proscribe violence against women , the reality is that violations against women 's rights are often sanctioned under the garb of cultural practices and norms , or through misinterpretation of religious tenets .",
  'Violence against women represents a serious concern worldwide .',
  'These variables are what make violence against women a preventable problem .',
  'There is growing recognition in the ranks of the South African government that violence against women is a serious problem facing us all .',
  'Research conducted in Australia and overseas provides an evidence base for the contention that violence against women is a serious problem for healthcare and society , and should be addressed comprehensively in both the healthcare and socio-legal context to protect the woman and the family .',
  'Violence against women is a serious social problem and affects mainly young women .',
  'Although this was an exploratory study , the results attest that female abuse is a serious social problem in this community , and that the rate of abuse exceeds that of other Palestinian groups .',
  'Sexual violence against women is a form of gender violence and both a severe human rights violation and public health problem .',
  'Violence against women is now widely recognized as a serious human right abuse , and an important public health problem with substantial consequences physical , mental , sexual , and reproductive health .',
  'Violence against women is widely recognized as a serious public health problem in the world .',
  'Spain seems to have a serious problem with public health and respecting human rights in obstetric violence .',
  'Gender violence is a human rights violation and a serious public health problem that should be addressed with an inter-sector and interdisciplinary focus .',
  'Gender-based violence against women is a serious concern in India .',
  'It was observed that health professionals characterize violence against women as a severe and important problem in society , caused by and leading to gender inequality .',
  "Violence against women represents a serious violation of women 's human rights and has been recognized as a clinical and public health problem , independently of nationality , ethnicity , cultural norms and socioeconomic status .",
  'Violence against women is a serious problem in Turkey .',
  'Violence against women is a serious health and social problem for women worldwide .',
  'violence against women is a serious problem caused by the social construction of feminineness and masculineness that results in the domination of women by men .',
  'Violence against women is recognized by globally as a serious health and social problem that impedes development .',
  'Violence against women ( VAW ) is a serious public health and human rights concern .',
  'Gender-based violence ( GBV ) is a serious global public health problem that becomes aggravated during public health emergencies that involve quarantine measures .',
  'Violence against women represents a serious problem in America .'],
 'gender': ["Violence against women , especially by intimate partners , is a serious public health problem that is associated with physical , reproductive and mental health consequences . Even though most societies proscribe violence against women , the reality is that violations against women 's rights are often sanctioned under the garb of cultural practices and norms , or through misinterpretation of religious tenets .",
  'Violence against women represents a serious concern worldwide .',
  'These variables are what make violence against women a preventable problem .',
  'There is growing recognition in the ranks of the South African government that violence against women is a serious problem facing us all .',
  'Research conducted in Australia and overseas provides an evidence base for the contention that violence against women is a serious problem for healthcare and society , and should be addressed comprehensively in both the healthcare and socio-legal context to protect the woman and the family .',
  'Violence against women is a serious social problem and affects mainly young women .',
  'Although this was an exploratory study , the results attest that female abuse is a serious social problem in this community , and that the rate of abuse exceeds that of other Palestinian groups .',
  'Sexual violence against women is a form of gender violence and both a severe human rights violation and public health problem .',
  'Violence against women is now widely recognized as a serious human right abuse , and an important public health problem with substantial consequences physical , mental , sexual , and reproductive health .',
  'Violence against women is widely recognized as a serious public health problem in the world .',
  'Spain seems to have a serious problem with public health and respecting human rights in obstetric violence .',
  'Gender violence is a human rights violation and a serious public health problem that should be addressed with an inter-sector and interdisciplinary focus .',
  'Gender-based violence against women is a serious concern in India .',
  'It was observed that health professionals characterize violence against women as a severe and important problem in society , caused by and leading to gender inequality .',
  "Violence against women represents a serious violation of women 's human rights and has been recognized as a clinical and public health problem , independently of nationality , ethnicity , cultural norms and socioeconomic status .",
  'Violence against women is a serious problem in Turkey .',
  'Violence against women is a serious health and social problem for women worldwide .',
  'violence against women is a serious problem caused by the social construction of feminineness and masculineness that results in the domination of women by men .',
  'Violence against women is recognized by globally as a serious health and social problem that impedes development .',
  'Violence against women ( VAW ) is a serious public health and human rights concern .',
  'Gender-based violence ( GBV ) is a serious global public health problem that becomes aggravated during public health emergencies that involve quarantine measures .',
  'Violence against women represents a serious problem in America .'],
 'nephrotoxicity': ['The main problem with cyclosporine is that in many responders proteinuria relapses when the drug is stopped .',
  'Cyclosporine A ( CsA ) is a potent immunosuppressant with the drawback of renal side effects .',
  'Cyclosporine A ( CsA ) is a potent immunosuppressant with the drawback of renal side-effects .',
  'Postischemic renal failure is a severe problem following cadaveric renal transplantation , especially if the kidney has been harvested from a non-heartbeating donor , and thereby subjected to periods of both warm and cold ischemia .',
  'Reconstruction of the urinary tract because of ureteral stricture after kidney transplantation is a serious problem .',
  'While sirolimus ( SRL ) is thought to be a non-nephrotoxic agent , cyclosporine A ( CsA ) toxicity is a serious problem in kidney transplantation .',
  'Despite huge progress in transplantation , renal transplantation remains a serious problem since patients treated with the calcineurin inhibitors cyclosporine and tacrolimus are at high risk of developing renal injury .',
  'Nephrotoxicity induced by antimicrobial or anticancer drugs is a serious clinical problem .',
  'Cyclosporin A (CyA)-induced nephrotoxicity is still a serious clinical problem .',
  'The nephrotoxicity of CYA , however , is a serious problem , and constitutes the major obstacle limiting the use of CYA as an immunosuppressive agent for renal transplantation .',
  'There have been no opportunistic infections , aseptic necrosis or peptic ulcers in this group and cyclosporine nephrotoxicity has not been a serious problem in the pediatric recipients .',
  'Bone loss remains a serious problem after kidney transplantation and is most pronounced during the first months after engraftment .',
  'Urological complications of kidney transplantation remain a serious postoperative problem .',
  'Delayed renal allograft function is a serious problem .',
  'Ureteral necrosis is a serious problem in kidney transplantation .',
  'Although kidney transplantation was hailed as an optimal solution to such devastating disease , many issues related to immune-suppressive drugs soon emerged and it became evident that cardiovascular disease would remain a vexing problem .',
  'Acute renal failure is a serious problem following heart transplantation .',
  'The exponential increase in the number of patients on the renal transplant waiting list globally has become a serious problem fueled by an increase in the number of patients with end-stage renal disease , the shortage of organs for transplant , and the failure of transplanted kidneys for various reasons .',
  'The immunosuppressive drug tacrolimus ( FK506 ) is used clinically to reduce the rejection rate in patients with kidney transplantation ; however , the resultant nephrotoxicity remains a serious problem .',
  'In transplant recipients , nephrotoxicity due to long-term use of calcineurin inhibitor ( CNI ) is a serious problem that can not be overlooked .',
  'However , the nephrotoxicity induced by FK506 remains a serious clinical problem .',
  'For renal transplant recipient treated with ICIs , the increased incidence of rejection is a serious concern .',
  'Renal failure after heart transplantation ( HTx ) still remains a serious problem , especially when cyclosporin A is used for immunosuppression in the early postoperative therapy .',
  'The nephrotoxicity induced by immunosuppressant FK506 remains a serious clinical problem , and the underlying mechanism has not been completely understood .',
  'Allograft loss remains a severe clinical problem after kidney transplantation .',
  'The prevalence of end-stage renal disease is emerging as a serious worldwide public health problem because of the shortage of donor organs and the need to take lifelong immunosuppressive medication in patients who receive a transplanted kidney .',
  'PVAN was the leading cause of renal loss in SPK patients in the first 2 years after transplantation and is a serious concern for SPK recipients .',
  'Cyclosporin has improved graft survival after renal transplantation , but cyclosporin nephrotoxicity is a severe clinical problem .',
  'Drug nephrotoxicity is a serious health and economic problem worldwide .',
  'Post-transplant renal osteopathy ( ROP ) remains a serious problem , which contributes to substantial long-term morbidity of the graft recipients .',
  'Acute tubular necrosis ( ATN ) represents a serious problem in kidney transplantation .'],
 'cyclosporine': ['The main problem with cyclosporine is that in many responders proteinuria relapses when the drug is stopped .',
  'Cyclosporine A ( CsA ) is a potent immunosuppressant with the drawback of renal side effects .',
  'Cyclosporine A ( CsA ) is a potent immunosuppressant with the drawback of renal side-effects .',
  'Postischemic renal failure is a severe problem following cadaveric renal transplantation , especially if the kidney has been harvested from a non-heartbeating donor , and thereby subjected to periods of both warm and cold ischemia .',
  'Reconstruction of the urinary tract because of ureteral stricture after kidney transplantation is a serious problem .',
  'While sirolimus ( SRL ) is thought to be a non-nephrotoxic agent , cyclosporine A ( CsA ) toxicity is a serious problem in kidney transplantation .',
  'Despite huge progress in transplantation , renal transplantation remains a serious problem since patients treated with the calcineurin inhibitors cyclosporine and tacrolimus are at high risk of developing renal injury .',
  'Nephrotoxicity induced by antimicrobial or anticancer drugs is a serious clinical problem .',
  'Cyclosporin A (CyA)-induced nephrotoxicity is still a serious clinical problem .',
  'The nephrotoxicity of CYA , however , is a serious problem , and constitutes the major obstacle limiting the use of CYA as an immunosuppressive agent for renal transplantation .',
  'There have been no opportunistic infections , aseptic necrosis or peptic ulcers in this group and cyclosporine nephrotoxicity has not been a serious problem in the pediatric recipients .',
  'Bone loss remains a serious problem after kidney transplantation and is most pronounced during the first months after engraftment .',
  'Urological complications of kidney transplantation remain a serious postoperative problem .',
  'Delayed renal allograft function is a serious problem .',
  'Ureteral necrosis is a serious problem in kidney transplantation .',
  'Although kidney transplantation was hailed as an optimal solution to such devastating disease , many issues related to immune-suppressive drugs soon emerged and it became evident that cardiovascular disease would remain a vexing problem .',
  'Acute renal failure is a serious problem following heart transplantation .',
  'The exponential increase in the number of patients on the renal transplant waiting list globally has become a serious problem fueled by an increase in the number of patients with end-stage renal disease , the shortage of organs for transplant , and the failure of transplanted kidneys for various reasons .',
  'The immunosuppressive drug tacrolimus ( FK506 ) is used clinically to reduce the rejection rate in patients with kidney transplantation ; however , the resultant nephrotoxicity remains a serious problem .',
  'In transplant recipients , nephrotoxicity due to long-term use of calcineurin inhibitor ( CNI ) is a serious problem that can not be overlooked .',
  'However , the nephrotoxicity induced by FK506 remains a serious clinical problem .',
  'For renal transplant recipient treated with ICIs , the increased incidence of rejection is a serious concern .',
  'Renal failure after heart transplantation ( HTx ) still remains a serious problem , especially when cyclosporin A is used for immunosuppression in the early postoperative therapy .',
  'The nephrotoxicity induced by immunosuppressant FK506 remains a serious clinical problem , and the underlying mechanism has not been completely understood .',
  'Allograft loss remains a severe clinical problem after kidney transplantation .',
  'The prevalence of end-stage renal disease is emerging as a serious worldwide public health problem because of the shortage of donor organs and the need to take lifelong immunosuppressive medication in patients who receive a transplanted kidney .',
  'PVAN was the leading cause of renal loss in SPK patients in the first 2 years after transplantation and is a serious concern for SPK recipients .',
  'Cyclosporin has improved graft survival after renal transplantation , but cyclosporin nephrotoxicity is a severe clinical problem .',
  'Drug nephrotoxicity is a serious health and economic problem worldwide .',
  'Post-transplant renal osteopathy ( ROP ) remains a serious problem , which contributes to substantial long-term morbidity of the graft recipients .',
  'Acute tubular necrosis ( ATN ) represents a serious problem in kidney transplantation .'],
 'cyclosporin': ['The main problem with cyclosporine is that in many responders proteinuria relapses when the drug is stopped .',
  'Cyclosporine A ( CsA ) is a potent immunosuppressant with the drawback of renal side effects .',
  'Cyclosporine A ( CsA ) is a potent immunosuppressant with the drawback of renal side-effects .',
  'Postischemic renal failure is a severe problem following cadaveric renal transplantation , especially if the kidney has been harvested from a non-heartbeating donor , and thereby subjected to periods of both warm and cold ischemia .',
  'Reconstruction of the urinary tract because of ureteral stricture after kidney transplantation is a serious problem .',
  'While sirolimus ( SRL ) is thought to be a non-nephrotoxic agent , cyclosporine A ( CsA ) toxicity is a serious problem in kidney transplantation .',
  'Despite huge progress in transplantation , renal transplantation remains a serious problem since patients treated with the calcineurin inhibitors cyclosporine and tacrolimus are at high risk of developing renal injury .',
  'Nephrotoxicity induced by antimicrobial or anticancer drugs is a serious clinical problem .',
  'Cyclosporin A (CyA)-induced nephrotoxicity is still a serious clinical problem .',
  'The nephrotoxicity of CYA , however , is a serious problem , and constitutes the major obstacle limiting the use of CYA as an immunosuppressive agent for renal transplantation .',
  'There have been no opportunistic infections , aseptic necrosis or peptic ulcers in this group and cyclosporine nephrotoxicity has not been a serious problem in the pediatric recipients .',
  'Bone loss remains a serious problem after kidney transplantation and is most pronounced during the first months after engraftment .',
  'Urological complications of kidney transplantation remain a serious postoperative problem .',
  'Delayed renal allograft function is a serious problem .',
  'Ureteral necrosis is a serious problem in kidney transplantation .',
  'Although kidney transplantation was hailed as an optimal solution to such devastating disease , many issues related to immune-suppressive drugs soon emerged and it became evident that cardiovascular disease would remain a vexing problem .',
  'Acute renal failure is a serious problem following heart transplantation .',
  'The exponential increase in the number of patients on the renal transplant waiting list globally has become a serious problem fueled by an increase in the number of patients with end-stage renal disease , the shortage of organs for transplant , and the failure of transplanted kidneys for various reasons .',
  'The immunosuppressive drug tacrolimus ( FK506 ) is used clinically to reduce the rejection rate in patients with kidney transplantation ; however , the resultant nephrotoxicity remains a serious problem .',
  'In transplant recipients , nephrotoxicity due to long-term use of calcineurin inhibitor ( CNI ) is a serious problem that can not be overlooked .',
  'However , the nephrotoxicity induced by FK506 remains a serious clinical problem .',
  'For renal transplant recipient treated with ICIs , the increased incidence of rejection is a serious concern .',
  'Renal failure after heart transplantation ( HTx ) still remains a serious problem , especially when cyclosporin A is used for immunosuppression in the early postoperative therapy .',
  'The nephrotoxicity induced by immunosuppressant FK506 remains a serious clinical problem , and the underlying mechanism has not been completely understood .',
  'Allograft loss remains a severe clinical problem after kidney transplantation .',
  'The prevalence of end-stage renal disease is emerging as a serious worldwide public health problem because of the shortage of donor organs and the need to take lifelong immunosuppressive medication in patients who receive a transplanted kidney .',
  'PVAN was the leading cause of renal loss in SPK patients in the first 2 years after transplantation and is a serious concern for SPK recipients .',
  'Cyclosporin has improved graft survival after renal transplantation , but cyclosporin nephrotoxicity is a severe clinical problem .',
  'Drug nephrotoxicity is a serious health and economic problem worldwide .',
  'Post-transplant renal osteopathy ( ROP ) remains a serious problem , which contributes to substantial long-term morbidity of the graft recipients .',
  'Acute tubular necrosis ( ATN ) represents a serious problem in kidney transplantation .'],
 'mosquito': ['The problem with chemical control of these mosquitoes is that the breeding sites are always well dispersed and not easily located , and more manenergy and money are required to treat them individually .',
  'Mosquito-borne viral infections are becoming common and a serious public health problem in DRC .',
  'Mass attacks by Hymenoptera have become a serious public health problem in tropics .',
  'Recently , the bed bug , Cimex lectularius L. has re-emerged as a serious and growing problem in many parts of the world .',
  'In recent years , resurgence of mosquito-borne diseases has become a serious health problem in India .',
  'Mosquitoes in Habahe County of Xinjiang Uigur Autonomous Region in China are considered a serious nuisance problem to local residents , but little is known of their role in enzootic disease .',
  'Mosquitoes are responsible for the transmission of a number of pathogens and may pose a serious nuisance problem .',
  'Worldwide invasion of Aedes albopictus ( Skuse ) has become a serious concern in vector control .',
  'Pathogenic mosquito-borne viruses are a serious public health issue in tropical and subtropical regions and are increasingly becoming a problem in other climate zones .',
  'A serious problem is posed by the inadvertent transport of live mosquitoes aboard aircraft arriving from tropical countries where vector-borne diseases are endemic .',
  'Mosquito control is a serious concern in developing countries like India due to the lack of general awareness , development of resistance , and socioeconomic reasons .',
  'The presence of different species of ( primarily insectivorous ) bats in urban areas represents a serious public health problem .',
  'Mosquito-borne diseases are a serious global problem , particularly in tropical and sub-tropical countries such as Nepal .',
  'Environmental disasters cause significant disruption of ecosystems , flooding , contamination of water supplies , and displacement of human populations , which can result in increases in transmission and outbreaks of mosquito-borne and zoonotic diseases that can become a serious and long-term public health problem for the region .',
  'Bed bugs have reemerged recently as a serious and growing problem not only in North America but in many parts of the world .',
  'Mosquito-borne diseases continue to be a serious public-health concern in Australia .',
  'The results showed that Shenzhen and Dongguan have a severe problem with bed bug infestations : the control of bed bugs is a constant concern , except during the winter .',
  'The unavailability of a vaccine and of anti-viral drugs has made this mosquito-borne disease a serious health concern .',
  'Mosquitoes constitute a severe health problem in many areas all over the world .'],
 'mosquitoes': ['The problem with chemical control of these mosquitoes is that the breeding sites are always well dispersed and not easily located , and more manenergy and money are required to treat them individually .',
  'Mosquito-borne viral infections are becoming common and a serious public health problem in DRC .',
  'Mass attacks by Hymenoptera have become a serious public health problem in tropics .',
  'Recently , the bed bug , Cimex lectularius L. has re-emerged as a serious and growing problem in many parts of the world .',
  'In recent years , resurgence of mosquito-borne diseases has become a serious health problem in India .',
  'Mosquitoes in Habahe County of Xinjiang Uigur Autonomous Region in China are considered a serious nuisance problem to local residents , but little is known of their role in enzootic disease .',
  'Mosquitoes are responsible for the transmission of a number of pathogens and may pose a serious nuisance problem .',
  'Worldwide invasion of Aedes albopictus ( Skuse ) has become a serious concern in vector control .',
  'Pathogenic mosquito-borne viruses are a serious public health issue in tropical and subtropical regions and are increasingly becoming a problem in other climate zones .',
  'A serious problem is posed by the inadvertent transport of live mosquitoes aboard aircraft arriving from tropical countries where vector-borne diseases are endemic .',
  'Mosquito control is a serious concern in developing countries like India due to the lack of general awareness , development of resistance , and socioeconomic reasons .',
  'The presence of different species of ( primarily insectivorous ) bats in urban areas represents a serious public health problem .',
  'Mosquito-borne diseases are a serious global problem , particularly in tropical and sub-tropical countries such as Nepal .',
  'Environmental disasters cause significant disruption of ecosystems , flooding , contamination of water supplies , and displacement of human populations , which can result in increases in transmission and outbreaks of mosquito-borne and zoonotic diseases that can become a serious and long-term public health problem for the region .',
  'Bed bugs have reemerged recently as a serious and growing problem not only in North America but in many parts of the world .',
  'Mosquito-borne diseases continue to be a serious public-health concern in Australia .',
  'The results showed that Shenzhen and Dongguan have a severe problem with bed bug infestations : the control of bed bugs is a constant concern , except during the winter .',
  'The unavailability of a vaccine and of anti-viral drugs has made this mosquito-borne disease a serious health concern .',
  'Mosquitoes constitute a severe health problem in many areas all over the world .'],
 'mri': ['The major problem with long-TE images is that the motion of the heart degrades the spatial resolution of the image during the TE period .',
  'A problem with this rotating-illumination scheme is that the tomographic data are inconsistent ; namely , the acoustic data recorded at each tomographic view angle ( i.e. , probe position ) are produced by a distinct object function .',
  'The problem with these methods is that they need to deal with intensity bias correction and other MRI-specific noise .',
  'Since the very early developments of microaxial tomography , a considerable drawback of this method was a complicated image acquisition and processing procedure that requires much operator time .',
  'Although paraCEST is a method with immense scope for generating image contrast in MRI , it suffers from the serious drawback of high detection limits .',
  'A major drawback of electrical impedance tomography is the poor quality of the conductivity images , i.e. , the low spatial resolution as well as large errors in the reconstructed conductivity values .',
  'A drawback of MR-guided interventions is the limitation in verbal communication during image acquisition .',
  'Long acquisition times have long been a major drawback of magnetic resonance imaging ( MRI ) and have limited its use for all those organ systems with various types of movement , such as respiration , pulsation , and peristalsis .',
  'The lack of stereopsis was a relative drawback of the system but was compensated for with repeated procedures .',
  'Despite the wide applicability and many fascinating aspects of image-guided navigation systems , a major drawback of this technology is they use images , mainly MRI pictures , acquired preoperatively , on which the planning of the operative procedure as well as its intraoperative performance is based .',
  'Unpleasant acoustic noise is a drawback of almost every MRI scan .',
  'A drawback of these current techniques is that the field map scans and the measurement can capture different patient positions , which invalidates the stationary condition .',
  'Motion during MRI examinations is a serious problem that degrades the quality of the data ( images ) acquired .',
  'However , there is a serious concern regarding its physical stability ; therefore , we investigated this issue using magnetic resonance imaging ( MRI ) .',
  'A serious problem encountered in this technique is the presence of artifacts due to patient motion .',
  'Artifacts caused by patient motion during scanning remain a serious problem in most MRI applications .'],
 'motion': ['The major problem with long-TE images is that the motion of the heart degrades the spatial resolution of the image during the TE period .',
  'A problem with this rotating-illumination scheme is that the tomographic data are inconsistent ; namely , the acoustic data recorded at each tomographic view angle ( i.e. , probe position ) are produced by a distinct object function .',
  'The problem with these methods is that they need to deal with intensity bias correction and other MRI-specific noise .',
  'Since the very early developments of microaxial tomography , a considerable drawback of this method was a complicated image acquisition and processing procedure that requires much operator time .',
  'Although paraCEST is a method with immense scope for generating image contrast in MRI , it suffers from the serious drawback of high detection limits .',
  'A major drawback of electrical impedance tomography is the poor quality of the conductivity images , i.e. , the low spatial resolution as well as large errors in the reconstructed conductivity values .',
  'A drawback of MR-guided interventions is the limitation in verbal communication during image acquisition .',
  'Long acquisition times have long been a major drawback of magnetic resonance imaging ( MRI ) and have limited its use for all those organ systems with various types of movement , such as respiration , pulsation , and peristalsis .',
  'The lack of stereopsis was a relative drawback of the system but was compensated for with repeated procedures .',
  'Despite the wide applicability and many fascinating aspects of image-guided navigation systems , a major drawback of this technology is they use images , mainly MRI pictures , acquired preoperatively , on which the planning of the operative procedure as well as its intraoperative performance is based .',
  'Unpleasant acoustic noise is a drawback of almost every MRI scan .',
  'A drawback of these current techniques is that the field map scans and the measurement can capture different patient positions , which invalidates the stationary condition .',
  'Motion during MRI examinations is a serious problem that degrades the quality of the data ( images ) acquired .',
  'However , there is a serious concern regarding its physical stability ; therefore , we investigated this issue using magnetic resonance imaging ( MRI ) .',
  'A serious problem encountered in this technique is the presence of artifacts due to patient motion .',
  'Artifacts caused by patient motion during scanning remain a serious problem in most MRI applications .'],
 'alcoholism': ['A limitation with this perspective is that it neglects the harm drinking causes to people around the drinker , and thus , it fails to give a full picture of alcohol-related harm in society .',
  'A problem with standard drink measures is that different distilled spirits , wines , and malt beverages vary considerably in alcohol content .',
  'Hazardous drinking ( HD ) is a serious health problem in people infected with human immunodeficiency virus type 1 ( HIV-1 ) .',
  'PRACTICAL APPLICATIONS : Alcohol abuse and alcoholism have become a serious public health problem worldwide .',
  'Alcoholism is a serious public health problem .',
  'Alcohol dependence is a serious public health problem .',
  'Alcohol relapse after transplantation is a serious concern in transplant centers and is a subject of controversy and debate .',
  'Most studies have been carried out on individuals with a serious drinking problem , in most cases alcoholics .',
  'Alcohol and violence on farms is a serious public health problem .',
  'Alcohol use disorders are a serious public health concern among soldiers .',
  'Alcohol consumption is a serious problem in terms of public health because it remains a major cause of illness and premature death .',
  'Alcohol misuse , in particular binge drinking , is a serious concern among military personnel because it is strongly associated with adverse consequences and has a deleterious effect on readiness .',
  'Alcohol use disorder ( AUD ) is a devastating public health problem in which both genetic and environmental factors play a role .',
  'Ethanol addiction is a serious public health problem that still needs more effective pharmacological treatment .',
  'The consequences of heavy alcohol use remain a serious public health problem .',
  'Thus , it could be argued that the majority of people " recover " from alcohol problems without treatment because a substantial proportion of these individuals did not actually have a severe alcohol problem .',
  'Hazardous drinking is a serious societal concern in military populations .',
  'Alcohol-induced immune activation and neuroinflammation are a serious health concern for PLWH .',
  'Possibly because staff do not identify alcohol use as a serious problem for psychiatric inpatients , it is not considered in treatment planning .',
  'Alcohol abuse poses a serious public health problem , and repeated ingestion can produce tolerance , leading to dependence and addiction .',
  "Alcoholism is a serious public health concern that is characterized by the development of tolerance to alcohol 's effects , increased consumption , loss of control over drinking and the development of physical dependence .",
  'Excessive alcohol consumption poses a serious problem for public health .',
  'Clearly the level of alcohol use and abuse is high in Spain and constitutes a severe public health and socioeconomic problem .',
  'Alcoholism in Islamic countries has such a low incidence that it is not yet considered a serious public health problem of the Moslem states .',
  'Alcohol dependence is a serious and common public health problem .',
  'Alcohol is the most commonly abused legal substance and alcoholism is a serious public health problem .',
  'A majority of cases had a severe drinking problem ; in fact , alcoholism was twice as common as initially anticipated .',
  'Alcoholism is a serious public health problem throughout the world .',
  'Alcohol-related violence is a serious and common social problem .',
  'Alcohol use disorders ( AUDs ) represent a severe , world-wide problem , and are usually comorbid with psychiatric disorders , comorbidity increases the risks associated with AUDs , and results in more serious consequences for patients .',
  'In recent years , alcohol-related health and social problems have become a serious concern in Japan because of the marked increase in per capita alcohol consumption .',
  'Binge drinking continues to be a serious public health concern .',
  'Excessive alcohol use is a serious public health concern worldwide , but less attention has been given to the prevalence , risk and protective factors , and consequences of early alcohol use in low-income , developing countries .',
  'Alcohol abuse and dependence are a serious public health problem .',
  'Due to its negative impact on both health and productivity , alcohol misuse is a serious concern in the workplace .',
  'One patient in 10 showed a severe alcohol-related problem .',
  'James Bond has a severe chronic alcohol problem .',
  'We wished to determine if offspring of families exhibiting a positive history of alcoholism ( FH+ ) reported a serious alcohol or drug problem ( including seeking treatment ) at a higher rate than those without such backgrounds ( FH- ) .',
  'This study revealed that problem drinking and alcohol dependence are a serious problem in Japanese general population .',
  'With the number of chronic heavy users of ethanol in the United States estimated to be 15 to 20 million and the evidence increasing that ethanol causes serious cardiac metabolic disturbances , ethanol abuse is obviously a serious problem and most likely is an important contributing factor to cardiac morbidity and mortality .',
  'Pathological and social consequences associated with excessive alcohol consumption and dependence constitute a serious concern for human well-being .',
  'Alcoholism is a serious health problem .',
  'Consumption of alcohol is a serious social problem .',
  'Harmful alcohol consumption in Germany is a serious public health problem : About 7.7 million adults in Germany can be classified as risky alcohol consumers , about 74,000 deaths per year are related to alcohol consumption , and about 1.8 million adults in Germany ( 18 - 64 \u2009 years ) are classified as alcohol dependent .',
  'Alcohol use disorder ( AUD ) persists as a devastating public health problem ; widely effective pharmacological treatments are needed .',
  'Alcohol is a serious public health concern that has a differential impact on individuals depending upon age and sex .',
  'Ethanol use disorders are a serious medical and public health problem in the world today .',
  'The Alcohol Dependence Syndrome ( ADS ) is a serious problem of public health .',
  'Despite a recent decline in per capita alcohol consumption , alcoholism remains a serious public health problem in France .',
  'Alcoholism is a serious public health problem and has been identified as the third major cause of preventable mortality in the world .',
  'False negatives in the assessment of lifetime alcohol use disorders : a serious but unappreciated problem .',
  'Alcohol dependence encompasses a serious medical and societal problem that constitutes a major public health concern .',
  'Alcohol abuse is a serious medical and social problem .',
  'Preliminary studies on the effects of antabus ( tetraethylthiuram disulfide ) in the therapy of alcoholic patients indicate that it is very valuable in providing a " chemical foundation " for sobriety , even in those with a severe , long term drinking problem .',
  'Injury is a serious problem for a substantial proportion of patients who undergo detoxification , particularly those with alcohol dependence .',
  'Problems with alcohol remain a serious public health concern despite decreased use among some populations .',
  'Alcohol dependence , a chronic relapsing brain disease with the characteristics of drinking alcohol out of control , has become a serious social problem .',
  'Outbreak of Botulism Due to Illicit Prison-Brewed Alcohol : Public Health Response to a Serious and Recurrent Problem .',
  '[ Editorial : Alcohol -- a serious problem ] .',
  'Intoxicated aggression is both a dangerous and a costly problem for society , with alcohol being involved in over 50 % of violent crimes , and the cost of alcohol-consumption-related crime being estimated at $ 205 billion in the United States alone .',
  'Despite extensive public health campaigns , the consequences of alcohol intoxication continue to be a serious public health concern .',
  'The prevalence of gastric mucosal injury caused by alcohol has been on the rise , which has been considered a serious problem .',
  'Alcoholism is a serious public health problem in Chile and the best treatment strategy for this problem is far from being clear .',
  'Patients with acute alcohol intoxication present a serious and still growing problem for pre- and intra-hospital emergency services .',
  'Despite the fact that alcoholism is a severe public health problem of worldwide proportions , only a limited number of medications is used as coadjuvant treatment .',
  'Each year , 17 million adults experience a serious problem with alcohol , but only 3 million get help .',
  'Alcohol dependence ( AD ) is a serious and common public health problem .',
  'Alcohol abuse and dependence represents a serious health problem worldwide with social , interpersonal and legal interpolations .',
  'With the exception of Denmark , alcohol has for a long time been regarded as a serious public health problem , and the reduction of total consumption of alcohol has been held as one of the most important ways of combating alcohol problems .',
  'Participants ( N = 25 ) with a severe mental illness who were receiving mental health outpatient treatment at a state psychiatric hospital were interviewed regarding the resolution of their alcohol problem .',
  'Alcoholism and alcohol-related problems in Latin America constitute a serious problem that may be increasing despite variations by ethnicity , country , and other variables .',
  "Although support was not found for anger as a mediator , there was strong convergence between AA 's explicit emphasis on anger and the present findings : Anger appears to be a serious , enduring problem related to relapse and heavy alcohol consumption .",
  'Alcohol abuse and dependence , defined in the Diagnostic and Statistical Manual of Mental Disorders ( 3rd edition , revised ) , is a serious mental health problem in older adults .',
  'Alcohol dependence constitutes a serious worldwide public health problem .',
  'Excessive alcohol intake can pose a serious problem in public health .',
  'Alcohol abuse is a serious health problem , leading to life-threatening damage to most of the important organ systems .',
  'At the HIV outpatient department of the University Hospital in Basel , nurses are assessing patients and it is evident that alcohol intake is a serious health problem for some of them .',
  'Alcohol abuse and addiction is not only a severe social problem , but also an important biological medical issue .',
  'The person with alcoholism was viewed as having a serious problem by only slightly more than half of the respondents .',
  'Historically , substance misuse has been a serious problem faced by worldwide military personnel .',
  'Problematic drinking is a serious and persistent problem among U.S. military service members and veterans , who face barriers to seeking help and are less likely to seek help than the civilian population .',
  'Western Balkan countries exhibit high levels of alcohol consumption , which constitutes a serious public health concern .',
  'Problem drinking is a serious public health problem in the workplace .',
  'Alcohol use disorder is a serious health problem with high comorbidities .',
  'Alcohol use disorders ( AUDs ) are a devastating public health problem .',
  'Alcohol-related diseases represent a serious problem all over the world and they show a gradually increasing tendency .',
  'Excessive alcohol intake is a serious but preventable public health problem in the United States and worldwide .',
  'Alcohol use disorder ( AUD ) is a serious public health problem that results in tremendous social , legal and medical costs to society .',
  'Alcoholism in the elderly . A serious but solvable problem .',
  'Ethanol withdrawal is a serious clinical problem owing in part to over stimulation of ionotropic glutamate receptors in the brain and is linked to elevated oxidative damage .',
  'Alcohol misuse has now become a serious public health problem and early intervention is important in minimizing the harm .',
  'Scotland has a serious problem with alcohol .',
  'Gastric mucosal damage induced by ethanol is a serious medical problem .',
  'Smoking is a serious health concern both globally and in the U.S. Because drinking amplifies the negative health effects of smoking , the high association of these behaviors is an additional source of population morbidity .',
  'Alcoholism is a serious problem throughout the world .',
  'Alcoholism , one of the most frequent diseases in the world , has been transformed in a serious social problem and in Brazil , it has triplicated in the last decades .',
  'Alcohol problems are a serious public health concern , and few problem drinkers ever seek treatment .',
  'Alcohol dependence poses a serious medical and sociological problem .',
  'A positive BT in the presence of a positive CAGE occurred in three patients and although insensitive it was absolutely specific for a serious drinking problem .',
  'Alcohol abuse is a serious health problem worldwide that causes a variety of physical and mental disorders .',
  'The findings , such as 3 % daily drinkers , clearly indicated a worrisome prevalence of non-ritual alcohol use among Israelis and reinforced the position that the phenomenon of drinking is liable to develop into an important social and public health problem in the State of Israel .',
  'Never previously reported is whether this " quantitative " approach to screening can be used to effectively screen ambulatory patients for the presence of a serious drinking problem .'],
 'schistosomiasis': ['Ocular lesions have been reported in patients with schistosomiasis ; however , the problem with studying schistosomal infection of the human eye is that biopsies are almost impossible to take , and histopathological examination of suspicious lesions can only be undertaken post-mortem or after enucleation .',
  'Schistosomiasis remains a serious public health problem , with 200 million people infected and 779 million people at risk worldwide .',
  'Despite the success of control programmes , schistosomiasis is still a serious public health problem in the world .',
  'Schistosomiasis is a neglected disease closely related to the low levels of social development and a serious public health problem .',
  'Schistosomiasis is a severe public health problem in the Dongting Lake region , and its distribution , prevalence , and intensity of infection are particularly sensitive to environmental changes .',
  'Schistosoma japonicum is one of the three major blood fluke species , the etiological agents of schistosomiasis which remains a serious public health problem with an estimated 200 million people infected in 76 countries .',
  'Schistosomiasis is a serious public health problem , prevalent in tropical and subtropical areas , especially in poor communities without access to safe drinking water and adequate sanitation .',
  'Schistosomiasis is a serious health problem especially in developing countries and affects more than 243 million people .',
  'Hepatic fibrosis caused by chronic infection with Schistosoma japonica remains a serious public health problem in the world .',
  'Schistosomiasis remains a serious public health problem with an estimated 200 million people infected in 76 countries .',
  'Urinary schistosomosis is a serious public health problem prevalent in low-income rural regions of sub-Saharan Africa , including coastal part of Kenya .',
  'Human schistosomiasis remains a serious worldwide public health problem .',
  'Schistosomiasis is one of the most important parasitic diseases present in developing countries configuring it as a serious public health problem , directly related to poverty and social disadvantage .',
  'Worldwide schistosomiasis continues to be a serious public health problem .',
  'Worldwide Schistosomiasis mansoni continues to be a serious public health problem .',
  "Schistosomiasis is one of the world 's most prevalent zoonotic diseases and a serious worldwide public health problem .",
  'Schistosome parasites still represent a serious public health concern and a major economic problem in developing countries .',
  'Urogenital schistosomiasis due to Schistosoma haematobium is a serious underestimated public health problem affecting 112 million people - particularly in sub-Saharan Africa .',
  'Schistosomiasis is a serious public health problem in Brazil and worldwide .',
  'Urogenital schistosomiaisis is a serious public health problem in sub-Saharan Africa .',
  'Schistosomiasis affects more than 200 million individuals worldwide , with a further 650 million living at risk of infection , constituting a severe health problem in developing countries .',
  'Schistosomiasis is a serious health problem in many parts of Africa which is linked to poor water quality and limited sanitation resources .',
  'Schistosomiasis remains a serious public health concern in China .',
  'A serious public health problem ensued , with an epidemic of intestinal schistosomiasis occurring in the previously schistosome-free Richard-Toll region within 2 years .',
  'In spite of the numerous efforts made to control their transmission , parasite schistosomes still represent a serious public health concern and a major economic problem in many developing countries .',
  'Schistosomiasis remains a severe problem of public health in developing countries .',
  "Manson 's schistosomiasis continues to be a severe public health problem in Brazil , where thousands of people live under the risk of contracting this parasitosis .",
  'Schistosomiasis is a serious global health problem that afflicts more than 230 million people in 77 countries .',
  'Schistosomiasis is a severe public health problem , which can cause tissue fibrosis and can even be fatal .',
  'Schistosomiasis remains a serious public health problem with 200 million people infected and 779 million people at risk worldwide .',
  'Schistosoma japonicum , once endemic all the East Asia , remains as a serious public health problem in certain regions .',
  'In spite of numerous efforts towards the control of its transmission , schistosomiasis still remains an important parasitic disease and represents a serious public health concern and a major economical problem in a lot of developing countries .',
  'Schistosomiasis is a debilitating disease that represents a major health problem in at least 74 tropical and subtropical countries .',
  'Schistosomiasis , caused by parasitic trematodes of the genus Schistosoma , remains a devastating public health problem , with over 200 million people infected and 779 million people at risk worldwide , especially in developing countries .',
  'Schistosomiasis caused by Schistosoma spp . is a serious public health concern , especially in sub-Saharan Africa .',
  'Schistosomiasis is a serious global problem and the second most devastating parasitic disease following malaria .',
  'Schistosomiasis japonica , caused by Schistosoma japonicum , is still a serious public health problem in China .',
  'Schistosomiasis is a severe public health problem in China .',
  'Worldwide schistosomiasis remains a serious public health problem with approximately 67 million people infected and 200 million at risk of infection from inhabiting or transiting endemically active regions .',
  'Schistosomiasis ( SCH ) and soil-transmitted helminthiasis ( STH ) are widely distributed in the Democratic Republic of the Congo ( DRC ) and constitute a serious public health problem .',
  "Although schistosomiasis remains a serious health problem worldwide , significant achievements in schistosomiasis control has been made in the People 's Republic of China .",
  'Schistosomiasis remains a serious health problem in Africa .',
  'Schistosomiasis remains a serious worldwide public health problem .',
  'Schistosomiasis , one of the most prevalent neglected tropical diseases , is a life-threatening public health problem in Yemen especially in rural communities .',
  'Schistosomiasis caused by schsitosomes is a serious global public health concern .',
  'Despite intensive long-term control programmes , schistosomiasis japonica remains a serious public health problem in China and the Philippines .',
  'As a complement to chemotherapy and other control approaches , the development of an effective vaccine is necessary to combat Schistosomiasis japonica that remains a serious public health problem in China .',
  'Schistosomiasis , caused mainly by S. mansoni , S. haematobium and S. japonicum , continues to be a serious tropical disease and public health problem resulting in an unacceptably high level of morbidity in countries where it is endemic .',
  'Schistosomiasis remains a severe problem of public health in developing countries .',
  'Intestinal schistosomiasis was not regarded as a serious health problem because a mass treatment programme is in place .',
  'The prevalence of scabies is high in children in the displacement camps , suggesting that it may be a serious public health problem not only in these camps , but also in the entire country .',
  'Schistosoma mansoni is a major causative agent of schistosomiasis , which constitutes a severe health problem in developing countries .',
  'Such savings might encourage more frequent measurements in regions where schistosomiasis is a serious but neglected problem .',
  'Schistosomiasis remains a serious public health problem in affected countries , and routine , highly sensitive and cost-effective diagnostic methods are lacking .',
  'The inherent morbidity and mortality caused by schistosomiasis is a serious public health problem in developing countries .',
  'Schistosomiasis is considered a serious public health problem in 78 countries and territories located in Africa , Asia and America and it is estimated in more than 249 million people infected by any of the species of Schistosoma .',
  'Schistosomiasis is endemic in 74 countries and is considered a serious public health problem in some locations .',
  'Schistosomiasis remains a serious world-wide public health problem with a still unfulfilled need for routine cost-effective methods of diagnosis .'],
 'schistosoma': ['Ocular lesions have been reported in patients with schistosomiasis ; however , the problem with studying schistosomal infection of the human eye is that biopsies are almost impossible to take , and histopathological examination of suspicious lesions can only be undertaken post-mortem or after enucleation .',
  'Schistosomiasis remains a serious public health problem , with 200 million people infected and 779 million people at risk worldwide .',
  'Despite the success of control programmes , schistosomiasis is still a serious public health problem in the world .',
  'Schistosomiasis is a neglected disease closely related to the low levels of social development and a serious public health problem .',
  'Schistosomiasis is a severe public health problem in the Dongting Lake region , and its distribution , prevalence , and intensity of infection are particularly sensitive to environmental changes .',
  'Schistosoma japonicum is one of the three major blood fluke species , the etiological agents of schistosomiasis which remains a serious public health problem with an estimated 200 million people infected in 76 countries .',
  'Schistosomiasis is a serious public health problem , prevalent in tropical and subtropical areas , especially in poor communities without access to safe drinking water and adequate sanitation .',
  'Schistosomiasis is a serious health problem especially in developing countries and affects more than 243 million people .',
  'Hepatic fibrosis caused by chronic infection with Schistosoma japonica remains a serious public health problem in the world .',
  'Schistosomiasis remains a serious public health problem with an estimated 200 million people infected in 76 countries .',
  'Urinary schistosomosis is a serious public health problem prevalent in low-income rural regions of sub-Saharan Africa , including coastal part of Kenya .',
  'Human schistosomiasis remains a serious worldwide public health problem .',
  'Schistosomiasis is one of the most important parasitic diseases present in developing countries configuring it as a serious public health problem , directly related to poverty and social disadvantage .',
  'Worldwide schistosomiasis continues to be a serious public health problem .',
  'Worldwide Schistosomiasis mansoni continues to be a serious public health problem .',
  "Schistosomiasis is one of the world 's most prevalent zoonotic diseases and a serious worldwide public health problem .",
  'Schistosome parasites still represent a serious public health concern and a major economic problem in developing countries .',
  'Urogenital schistosomiasis due to Schistosoma haematobium is a serious underestimated public health problem affecting 112 million people - particularly in sub-Saharan Africa .',
  'Schistosomiasis is a serious public health problem in Brazil and worldwide .',
  'Urogenital schistosomiaisis is a serious public health problem in sub-Saharan Africa .',
  'Schistosomiasis affects more than 200 million individuals worldwide , with a further 650 million living at risk of infection , constituting a severe health problem in developing countries .',
  'Schistosomiasis is a serious health problem in many parts of Africa which is linked to poor water quality and limited sanitation resources .',
  'Schistosomiasis remains a serious public health concern in China .',
  'A serious public health problem ensued , with an epidemic of intestinal schistosomiasis occurring in the previously schistosome-free Richard-Toll region within 2 years .',
  'In spite of the numerous efforts made to control their transmission , parasite schistosomes still represent a serious public health concern and a major economic problem in many developing countries .',
  'Schistosomiasis remains a severe problem of public health in developing countries .',
  "Manson 's schistosomiasis continues to be a severe public health problem in Brazil , where thousands of people live under the risk of contracting this parasitosis .",
  'Schistosomiasis is a serious global health problem that afflicts more than 230 million people in 77 countries .',
  'Schistosomiasis is a severe public health problem , which can cause tissue fibrosis and can even be fatal .',
  'Schistosomiasis remains a serious public health problem with 200 million people infected and 779 million people at risk worldwide .',
  'Schistosoma japonicum , once endemic all the East Asia , remains as a serious public health problem in certain regions .',
  'In spite of numerous efforts towards the control of its transmission , schistosomiasis still remains an important parasitic disease and represents a serious public health concern and a major economical problem in a lot of developing countries .',
  'Schistosomiasis is a debilitating disease that represents a major health problem in at least 74 tropical and subtropical countries .',
  'Schistosomiasis , caused by parasitic trematodes of the genus Schistosoma , remains a devastating public health problem , with over 200 million people infected and 779 million people at risk worldwide , especially in developing countries .',
  'Schistosomiasis caused by Schistosoma spp . is a serious public health concern , especially in sub-Saharan Africa .',
  'Schistosomiasis is a serious global problem and the second most devastating parasitic disease following malaria .',
  'Schistosomiasis japonica , caused by Schistosoma japonicum , is still a serious public health problem in China .',
  'Schistosomiasis is a severe public health problem in China .',
  'Worldwide schistosomiasis remains a serious public health problem with approximately 67 million people infected and 200 million at risk of infection from inhabiting or transiting endemically active regions .',
  'Schistosomiasis ( SCH ) and soil-transmitted helminthiasis ( STH ) are widely distributed in the Democratic Republic of the Congo ( DRC ) and constitute a serious public health problem .',
  "Although schistosomiasis remains a serious health problem worldwide , significant achievements in schistosomiasis control has been made in the People 's Republic of China .",
  'Schistosomiasis remains a serious health problem in Africa .',
  'Schistosomiasis remains a serious worldwide public health problem .',
  'Schistosomiasis , one of the most prevalent neglected tropical diseases , is a life-threatening public health problem in Yemen especially in rural communities .',
  'Schistosomiasis caused by schsitosomes is a serious global public health concern .',
  'Despite intensive long-term control programmes , schistosomiasis japonica remains a serious public health problem in China and the Philippines .',
  'As a complement to chemotherapy and other control approaches , the development of an effective vaccine is necessary to combat Schistosomiasis japonica that remains a serious public health problem in China .',
  'Schistosomiasis , caused mainly by S. mansoni , S. haematobium and S. japonicum , continues to be a serious tropical disease and public health problem resulting in an unacceptably high level of morbidity in countries where it is endemic .',
  'Schistosomiasis remains a severe problem of public health in developing countries .',
  'Intestinal schistosomiasis was not regarded as a serious health problem because a mass treatment programme is in place .',
  'The prevalence of scabies is high in children in the displacement camps , suggesting that it may be a serious public health problem not only in these camps , but also in the entire country .',
  'Schistosoma mansoni is a major causative agent of schistosomiasis , which constitutes a severe health problem in developing countries .',
  'Such savings might encourage more frequent measurements in regions where schistosomiasis is a serious but neglected problem .',
  'Schistosomiasis remains a serious public health problem in affected countries , and routine , highly sensitive and cost-effective diagnostic methods are lacking .',
  'The inherent morbidity and mortality caused by schistosomiasis is a serious public health problem in developing countries .',
  'Schistosomiasis is considered a serious public health problem in 78 countries and territories located in Africa , Asia and America and it is estimated in more than 249 million people infected by any of the species of Schistosoma .',
  'Schistosomiasis is endemic in 74 countries and is considered a serious public health problem in some locations .',
  'Schistosomiasis remains a serious world-wide public health problem with a still unfulfilled need for routine cost-effective methods of diagnosis .'],
 'vaccine': ['The problem with this binary , however , is that it can not account for the full spectrum of responsibilities and social norms that parents enact in vaccine decisions .',
  'Although most mothers had low knowledge about PCV , did not perceive themselves as susceptible to the disease , perceived that cost was the main barrier to PCV access , and obtained little information on PCV , they considered pneumonia as a severe disease and a priority health problem , perceived benefits of the vaccine , and were likely to adopt it .',
  'Reduction in routine immunization coverage may represent a serious life-threating problem for unvaccinated or under-vaccinated children .',
  'Controversy is grounded in moral , religious , political , economic , and sociocultural arguments including whether concerns that the vaccine increases sexual risk taking , sends mixed messages about abstaining from sexual intercourse , usurps parental authority , and increases the potential for development of new health disparities are offset by the value of administering a cost-effective , age-appropriate public health measure targeting a life-threatening problem .',
  'It represents a serious public health concern and vaccination constitutes an important tool to reduce or at least mitigate its burden .',
  'This vaccine , noncompliance mostly linked to the refusal of patients , is a worrisome public health problem , on which physicians and hospital staff in charge , as well as institutions , should turn attention toward a multi-professional preventive strategy against the morbidity risk of this infectious disease .',
  'FS occurrence in children is a serious concern because it leads to public apprehension of vaccinations .',
  'Some reasons for vaccine denial , " not believing in vaccine efficacy " ( 34.7 % to 14.9 % ) , " not considering flu as a serious problem " ( from 24 % to 12.6 % ) , " thinking not to get sick " ( 28.7 % to 18.2 % ) or " being against the vaccine " ( 32.7 % to 21 % ) , showed a statistically significant reduction after the exposure to the campaign .',
  'During the past few years , vaccine shortage has been a serious problem affecting both developed and developing countries .',
  'Declining childhood immunization represents a serious public health problem globally and in New Zealand .',
  'The movements of the opponents of vaccination appear to be more effective than the planned education of doctors and their patients , and the absence of sufficient administrative control performance of vaccination , raises a serious problem in contemporary clinical researcher .',
  'Because the problem of childhood underimmunization continues to be a serious concern for specific populations , it is essential that mothers have access to information that is concise , user friendly , and written at their level of understanding .',
  'Missing vaccination certificates pose a severe problem regarding the interpretability of vaccination data .',
  'The best safeguard against litigation , when and if a serious reaction follows vaccination , is the indication that these considerations were discussed and that an informed choice was made .',
  'Vaccine refusal is a serious public health problem , especially in the context of diseases with potential to spark global pandemics , such as Ebola virus disease in the Democratic Republic of the Congo .',
  'It presents a serious problem since recently clinical efficacy of the number of cancer vaccines has been demonstrated that focused a lot of public attention .'],
 'vaccination': ['The problem with this binary , however , is that it can not account for the full spectrum of responsibilities and social norms that parents enact in vaccine decisions .',
  'Although most mothers had low knowledge about PCV , did not perceive themselves as susceptible to the disease , perceived that cost was the main barrier to PCV access , and obtained little information on PCV , they considered pneumonia as a severe disease and a priority health problem , perceived benefits of the vaccine , and were likely to adopt it .',
  'Reduction in routine immunization coverage may represent a serious life-threating problem for unvaccinated or under-vaccinated children .',
  'Controversy is grounded in moral , religious , political , economic , and sociocultural arguments including whether concerns that the vaccine increases sexual risk taking , sends mixed messages about abstaining from sexual intercourse , usurps parental authority , and increases the potential for development of new health disparities are offset by the value of administering a cost-effective , age-appropriate public health measure targeting a life-threatening problem .',
  'It represents a serious public health concern and vaccination constitutes an important tool to reduce or at least mitigate its burden .',
  'This vaccine , noncompliance mostly linked to the refusal of patients , is a worrisome public health problem , on which physicians and hospital staff in charge , as well as institutions , should turn attention toward a multi-professional preventive strategy against the morbidity risk of this infectious disease .',
  'FS occurrence in children is a serious concern because it leads to public apprehension of vaccinations .',
  'Some reasons for vaccine denial , " not believing in vaccine efficacy " ( 34.7 % to 14.9 % ) , " not considering flu as a serious problem " ( from 24 % to 12.6 % ) , " thinking not to get sick " ( 28.7 % to 18.2 % ) or " being against the vaccine " ( 32.7 % to 21 % ) , showed a statistically significant reduction after the exposure to the campaign .',
  'During the past few years , vaccine shortage has been a serious problem affecting both developed and developing countries .',
  'Declining childhood immunization represents a serious public health problem globally and in New Zealand .',
  'The movements of the opponents of vaccination appear to be more effective than the planned education of doctors and their patients , and the absence of sufficient administrative control performance of vaccination , raises a serious problem in contemporary clinical researcher .',
  'Because the problem of childhood underimmunization continues to be a serious concern for specific populations , it is essential that mothers have access to information that is concise , user friendly , and written at their level of understanding .',
  'Missing vaccination certificates pose a severe problem regarding the interpretability of vaccination data .',
  'The best safeguard against litigation , when and if a serious reaction follows vaccination , is the indication that these considerations were discussed and that an informed choice was made .',
  'Vaccine refusal is a serious public health problem , especially in the context of diseases with potential to spark global pandemics , such as Ebola virus disease in the Democratic Republic of the Congo .',
  'It presents a serious problem since recently clinical efficacy of the number of cancer vaccines has been demonstrated that focused a lot of public attention .'],
 'headache': ['A problem with all migraine analgesics is that in long lasting migraine attacks , the headache can recur as the pharmacological effect of the medication wears off .',
  '10 % to 30 % of all children worldwide suffer from headaches at least once a week , potentially constituting a serious health problem that may lead to impairment in multiple areas .',
  'MOH is a common headache disorder and a serious public health problem all over the world .',
  'Cervicogenic headache ( CH ) is a debilitating pain problem , estimated to affect 13 - 17 % of the population with chronic headache .',
  'Headaches , although common occurrences in the elderly , can be the symptoms of a serious problem .',
  "Headaches are a serious public health concern of our days , affecting about 50 % of the world 's adult population .",
  'Headache is the most frequent neurological symptom and the most prevalent pain in children and adolescents , and constitutes a serious health problem that may lead to impairment in several areas .',
  'Migraine is a serious health problem which impair quality of life .',
  'Migraine , a common neurovascular brain disorder , represents a severe and widespread health problem ; along with medication-induced ( medication-overuse ) headache , it is the third-leading cause of disability worldwide .',
  'The therapeutic gain over placebo is modest ( + /- 11 % ) , but chronic migraine is most disabling , often drug resistant and a serious public health problem , as it affects 1 - 2 % of people in the general population .',
  'Red flags in children who present with headache -- how to recognize a serious problem .'],
 'migraine': ['A problem with all migraine analgesics is that in long lasting migraine attacks , the headache can recur as the pharmacological effect of the medication wears off .',
  '10 % to 30 % of all children worldwide suffer from headaches at least once a week , potentially constituting a serious health problem that may lead to impairment in multiple areas .',
  'MOH is a common headache disorder and a serious public health problem all over the world .',
  'Cervicogenic headache ( CH ) is a debilitating pain problem , estimated to affect 13 - 17 % of the population with chronic headache .',
  'Headaches , although common occurrences in the elderly , can be the symptoms of a serious problem .',
  "Headaches are a serious public health concern of our days , affecting about 50 % of the world 's adult population .",
  'Headache is the most frequent neurological symptom and the most prevalent pain in children and adolescents , and constitutes a serious health problem that may lead to impairment in several areas .',
  'Migraine is a serious health problem which impair quality of life .',
  'Migraine , a common neurovascular brain disorder , represents a severe and widespread health problem ; along with medication-induced ( medication-overuse ) headache , it is the third-leading cause of disability worldwide .',
  'The therapeutic gain over placebo is modest ( + /- 11 % ) , but chronic migraine is most disabling , often drug resistant and a serious public health problem , as it affects 1 - 2 % of people in the general population .',
  'Red flags in children who present with headache -- how to recognize a serious problem .'],
 'headaches': ['A problem with all migraine analgesics is that in long lasting migraine attacks , the headache can recur as the pharmacological effect of the medication wears off .',
  '10 % to 30 % of all children worldwide suffer from headaches at least once a week , potentially constituting a serious health problem that may lead to impairment in multiple areas .',
  'MOH is a common headache disorder and a serious public health problem all over the world .',
  'Cervicogenic headache ( CH ) is a debilitating pain problem , estimated to affect 13 - 17 % of the population with chronic headache .',
  'Headaches , although common occurrences in the elderly , can be the symptoms of a serious problem .',
  "Headaches are a serious public health concern of our days , affecting about 50 % of the world 's adult population .",
  'Headache is the most frequent neurological symptom and the most prevalent pain in children and adolescents , and constitutes a serious health problem that may lead to impairment in several areas .',
  'Migraine is a serious health problem which impair quality of life .',
  'Migraine , a common neurovascular brain disorder , represents a severe and widespread health problem ; along with medication-induced ( medication-overuse ) headache , it is the third-leading cause of disability worldwide .',
  'The therapeutic gain over placebo is modest ( + /- 11 % ) , but chronic migraine is most disabling , often drug resistant and a serious public health problem , as it affects 1 - 2 % of people in the general population .',
  'Red flags in children who present with headache -- how to recognize a serious problem .'],
 'pregnancy': ['The problem with analyzing decidual tissues from spontaneous abortions is that cause versus effect phenomena are difficult to distinguish .',
  'Data from this study showed that exposure to medication is a serious health problem for women of reproductive age and it contributes to the increase in the number of hospitalizations .',
  'Substance abuse during pregnancy continues to be a serious health problem in the United States .',
  'Teenage pregnancy is a socio-economic challenge and a serious public health problem for communities in South Africa .',
  "Malaria infection during pregnancy is a serious health problem in most of the world 's tropical regions .",
  'Use of alcohol and drugs during pregnancy is regarded as a serious problem in the medical field .',
  'Anaemia is a serious problem in pregnancy in malaria-endemic countries .',
  'Connected with perinatal diseases as well as gastrointestinal and respiratory infections malaria has been still a serious health problem of that region .',
  'Unplanned pregnancies among college/tertiary female students pose a serious public health concern in South Africa ( SA ) and are associated with adverse health and social outcomes that impact negatively on educational progress and future career prospects .',
  'Fetal Alcohol Syndrome ( FAS ) has been recognized as a serious developmental problem occurring in some offspring of alcoholic women .',
  'Rejection episodes were occasionally a serious problem , occurring in 9 % of the pregnancies .',
  "We use data from the Fragile Families and Child Wellbeing Study , augmented with information from hospital medical records , to estimate the effects of the birth of a child with a severe health problem on the likelihood that the infant 's father engages in illegal activities .",
  '" Brazil is the world champion of caesareans . " This prowess points out a serious public health problem . While the increase in the percentage of caesareans among all deliveries is an international phenomenon , it is highest by far in Brazil , where caesareans account for nearly 40 % of births , that is , three times the maximum recommended by WHO .',
  'In Pakistan , like other developing countries , utilization of family planning methods is a serious public health concern among married women .',
  'Malaria in pregnancy is a serious health problem that contributes greatly to maternal morbidity and mortality .',
  'Teenage pregnancy rates have declined over the last years but still remains a serious medical and social problem .',
  'Unintended pregnancy is a serious problem in the United States .',
  'Unplanned pregnancy is a serious and frequently occurring problem among ADAF women , with many opportunities for prevention .',
  'Illicit drug use during pregnancy is a serious social and public health problem inflicting an array of deleterious effects on both mother and offspring .',
  'Multivariable regression analysis indicated that female pediatricians , adolescent medicine subspecialists , agreeing that pregnancy is a serious problem for adolescents in their practice , and having read the AAP policy statement predicted high knowledge about IUDs as well as Implants for adolescents .',
  'Foetal exposure to maternally administered opiates such as morphine represent a serious human health problem but disposition studies in man are difficult to perform .',
  'The lack of information needed to assess the safety of drug treatments during human pregnancy remains a serious public health problem .',
  'Teenage pregnancy is a serious public health and social problem , with 95 % occurring in developing countries .',
  'Cocaine addiction is a serious health problem for pregnant women and their babies .',
  'Lack of local data on pregnancy intendedness poses a serious problem for those responsible for regional program development and evaluation .',
  'Globally , adolescent pregnancy constitutes a serious public health problem of a multifactorial nature .',
  "The rise in teenage pregnancy and young people 's vulnerability to HIV have been a serious problem .",
  '[ Teenage fecundity rates in Chile : a serious public health problem ] .',
  'Background Teenage pregnancies constitute a serious health and social problem worldwide .',
  'The mass incarceration of pregnant and parenting women is a serious problem in U.S. A policy focus is needed that takes a public health approach .',
  'The excessive intake of alcohol is a serious public health problem , especially given the severe damage provoked by chronic or prenatal exposure to alcohol that affects many physiological processes , such as memory , motor function , and cognitive abilities .',
  'In the United States , unintended pregnancy is a serious health , social , and economic concern .',
  'The recurrent abortion syndrome has been considered a serious obstetrical problem , since it was not possible to diagnose the causes in over 40 % of the cases .',
  'Drinking alcohol in pregnancy is a serious public health concern worldwide .',
  'Malaria during pregnancy remains a serious public health problem , with substantial risks for the mother , her foetus and the newborn .',
  'Recurrent pregnancy loss is a devastating health problem that affects many couples who are trying to establish a family .',
  'This conservative rate -- nearly one in every 100 live births -- confirms the perception of many health professionals that fetal alcohol exposure is a serious problem .',
  'Recurrent miscarriage is a serious clinical problem that affects 1 - 5 % of all couples trying to conceive .',
  'Unintended pregnancy is a serious concern in reproductive health which needs to be addressed .',
  'Recurrent pregnancy loss ( RPL ) is a serious problem for pregnancy .',
  'Overall , 34 % of women and 31 % of men felt that prematurity is a common problem in the United States , and 38 % of women and 25 % of men believed prematurity to be a serious problem in the United States .',
  'Recurrent spontaneous abortion ( RSA ) is a serious problem in pregnancy .',
  'Malaria in pregnancy remains a serious public health problem in the Republic of Congo despite the implementation of intermittent preventive treatment with sulfadoxine-pyrimethamine ( IPTp-SP ) in 2006 .',
  'Drug of abuse consumption throughout pregnancy is a serious public health problem and an important economic cost to the health system .',
  'Teenage pregnancy has become a serious public health problem , particularly in developing countries with limited obstetric facilities .',
  'Recurrent pregnancy loss ( RPL ) is a devastating reproductive problem affecting approximately 5 % of couples trying to conceive .',
  'The use of addictive substances during pregnancy is a serious social problem , not only because of effects on the health of the woman and child , but also because drug or alcohol dependency detracts from child care and enhances the prospect of child neglect and family breakdown .',
  'Placental malaria is a serious problem in sub-Saharan Africa .',
  'Recurrent pregnancy loss ( RPL ) is a serious problem in the reproductive age women .',
  'Whether or not increased prevalence of oral contraceptive use in developing countries is associated with increased morbidity and mortality from circulatory system diseases is a serious concern for health and family planning administrators .',
  'Drinking alcohol in pregnancy is of a serious public health concern worldwide .',
  'Maternal substance abuse is a serious problem with significant adverse effects to mothers , fetuses , and children .',
  'Unplanned pregnancies are a serious health concern in Wisconsin .',
  'A greater percentage would terminate a pregnancy for a serious medical problem .',
  "Adolescent pregnancy , occurring in girls aged 10 - 19 years , remains a serious health and social problem worldwide , and has been associated with numerous risk factors evident in the young people 's family , peer , school , and neighbourhood contexts .",
  'Recurrent pregnancy loss is a vexing problem facing many couples .',
  'Sexual relations with intercourse ( ASR-I ) and high prevalence of teen pregnancies ( 19.2 % , in 2002 ) among adolescents in Puerto Rico constitute a serious biopsychosocial problem .',
  'Unwanted pregnancy causes a serious health , economic , and social problem to the woman and her family .',
  'Malaria during pregnancy remains a serious public health problem .',
  'In Colombia , with higher frequency of Plasmodium vivax over Plasmodium falciparum infection , recent reports confirmed gestational malaria as a serious public health problem .',
  'Fetal alcohol exposure is a serious social and public health problem .',
  'Analysis of data from the 1988 National Survey of Family Growth -- corrected for the underreporting of abortion -- reveals that contraceptive failure during the first year of use remains a serious problem in the United States , contributing substantially to unintended pregnancy .',
  'Prenatal alcohol exposure ( PAE ) continues to be a serious public health problem , yet no reliable clinical tools are available for assessing levels of drinking during pregnancy .',
  'Fetal alcohol syndrome ( FAS ) is a serious global health problem and is observed at high frequencies in certain South African communities .',
  'Fetal exposure to alcohol is a serious public health problem and is associated with anomalies of the eye ground , as well as neurodevelopmental delay , growth delay , and characteristic facial features .',
  'Fetal drug addiction is a serious public health problem .',
  'A serious problem is the evaluation of retrospective drug risks in cases of drugs administered before pregnancy was confirmed .',
  'Unintended pregnancy is a serious problem in the United States .',
  'Placental malaria ( PM ) remains a severe public health problem in areas of high malaria transmission .',
  'Teen pregnancy . Why it remains a serious social , economic , and educational problem in the U.S.',
  'Malaria during pregnancy remains a serious public health problem .',
  'Fetal alcohol spectrum disorder ( FASD ) is a serious and widespread problem in this country .',
  'A variety of public education programs developed over the last 20 years have promoted alcohol abstention during pregnancy , yet FASD remains a serious public health concern .',
  'The growing number of pregnant women using illicit substances presents a serious public health concern .',
  'Recurrent pregnancy loss is a vexing problem facing many couples and doctors .',
  'Consumption of drugs of abuse , tobacco and alcohol throughout pregnancy is a serious public health problem and results in an important economic cost to the health system .',
  'Heroin abuse during pregnancy is a serious problem worldwide .',
  'Drug abuse by pregnant women is considered a serious public health problem worldwide .',
  'Pregnancy in adolescence constitutes a serious public health problem at these ages .',
  'Hence , alterations in its activity caused by the transfer of maternal drugs over a prolonged period of time could pose a serious problem to nurslings when they require drugs for their own benefit .'],
 'caesareans': ['The problem with analyzing decidual tissues from spontaneous abortions is that cause versus effect phenomena are difficult to distinguish .',
  'Rejection episodes were occasionally a serious problem , occurring in 9 % of the pregnancies .',
  '" Brazil is the world champion of caesareans . " This prowess points out a serious public health problem . While the increase in the percentage of caesareans among all deliveries is an international phenomenon , it is highest by far in Brazil , where caesareans account for nearly 40 % of births , that is , three times the maximum recommended by WHO .',
  'The recurrent abortion syndrome has been considered a serious obstetrical problem , since it was not possible to diagnose the causes in over 40 % of the cases .',
  'Recurrent pregnancy loss is a devastating health problem that affects many couples who are trying to establish a family .',
  'Recurrent miscarriage is a serious clinical problem that affects 1 - 5 % of all couples trying to conceive .',
  'Recurrent pregnancy loss ( RPL ) is a serious problem for pregnancy .',
  'Recurrent spontaneous abortion ( RSA ) is a serious problem in pregnancy .',
  'Recurrent pregnancy loss ( RPL ) is a devastating reproductive problem affecting approximately 5 % of couples trying to conceive .',
  'Recurrent pregnancy loss ( RPL ) is a serious problem in the reproductive age women .',
  'Recurrent pregnancy loss is a vexing problem facing many couples .',
  'Recurrent pregnancy loss is a vexing problem facing many couples and doctors .'],
 'conceive': ['The problem with analyzing decidual tissues from spontaneous abortions is that cause versus effect phenomena are difficult to distinguish .',
  'Rejection episodes were occasionally a serious problem , occurring in 9 % of the pregnancies .',
  '" Brazil is the world champion of caesareans . " This prowess points out a serious public health problem . While the increase in the percentage of caesareans among all deliveries is an international phenomenon , it is highest by far in Brazil , where caesareans account for nearly 40 % of births , that is , three times the maximum recommended by WHO .',
  'The recurrent abortion syndrome has been considered a serious obstetrical problem , since it was not possible to diagnose the causes in over 40 % of the cases .',
  'Recurrent pregnancy loss is a devastating health problem that affects many couples who are trying to establish a family .',
  'Recurrent miscarriage is a serious clinical problem that affects 1 - 5 % of all couples trying to conceive .',
  'Recurrent pregnancy loss ( RPL ) is a serious problem for pregnancy .',
  'Recurrent spontaneous abortion ( RSA ) is a serious problem in pregnancy .',
  'Recurrent pregnancy loss ( RPL ) is a devastating reproductive problem affecting approximately 5 % of couples trying to conceive .',
  'Recurrent pregnancy loss ( RPL ) is a serious problem in the reproductive age women .',
  'Recurrent pregnancy loss is a vexing problem facing many couples .',
  'Recurrent pregnancy loss is a vexing problem facing many couples and doctors .'],
 'wine': ['However , the problem with many of the cross-sectional studies of wine expertise that have been published to date is that they simply can not rule out the possibility that those with superior chemosensory abilities end-up gravitating toward a career in wine .',
  'One major problem associated with PBRs however , is that the bacteria usually associated with microalgae in nonaxenic cultures can lead to biofouling and thereby affect algal productivity .',
  'Agglomeration of bFGF at low salt concentrations was a serious problem .',
  "Fermentations carried out at 450-L and 20-L scale to produce Fab ' antibody fragments indicated a serious problem to control levels of dissolved oxygen in the broth due to the large oxygen demand at high cell densities .",
  'Since biofouling organisms are a serious problem in culture , competing with the scallops for food and oxygen , environmentally-friendly methods are required to mitigate the effects of this fouling in the culture systems .',
  'Microbial contamination of alcoholic fermentation processes ( e.g. winemaking and fuel-ethanol production ) is a serious problem for the industry since it may render the product unacceptable and/or reduce its productivity , leading to large economic losses .',
  'Protein haze remains a serious problem for the wine industry and requires costly bentonite treatment , leading to significant wine volume loss .',
  'The fermentation of industrial bacteria encounters a serious problem in continuous culture , i.e. the production traits lose .',
  'However , melanin accumulation during culture represents a serious problem for the purification of erythritol from the fermentation broth .',
  'Biofouling is a serious problem in marine aquaculture and it has a number of negative impacts including increased forces on aquaculture structures and reduced water exchange across nets .',
  'Tartaric instability of wines still represents a serious problem in terms of the commercial value of bottled wines , particularly whites , leading consumers to be suspicious as regards the effective healthiness or wholesomeness of products .',
  'The disposal of bio-waste ( e.g. , Corynebacterium glutamicum ) produced by the fermentation industry is a serious problem and has a negative impact on economic returns .',
  'Contamination of bacteria in large-scale yeast fermentations is a serious problem and a threat to the development of successful biofuel production plants .',
  'This is an off-flavor that is a serious problem for the wine industry .',
  'Acetic acid bacteria ( AAB ) irreversibly spoil wines and represent a serious problem .',
  'Biofouling is a severe problem of any water borne structure .',
  'Brettanomyces bruxellensis spoilage is a serious problem for the wine industry .',
  'Foaming of the culture medium had not been encountered previously , but was a serious problem in pilot scale production due to the very rapid growth of a large volume of L. giganteum .',
  'Grape pomace ( GP ) from Vitis labrusca , the main byproduct from " American table wine " production , is recalcitrant to degradation , and its accumulation is a serious problem with negative environmental impacts .',
  'Cork taint in wine is a serious problem which is exacerbated by the difficulty of its assessment .',
  'It was thought that energy supply is a severe problem for anaerobic fermentation of glycerol to produce succinate .'],
 'fermentation': ['However , the problem with many of the cross-sectional studies of wine expertise that have been published to date is that they simply can not rule out the possibility that those with superior chemosensory abilities end-up gravitating toward a career in wine .',
  'One major problem associated with PBRs however , is that the bacteria usually associated with microalgae in nonaxenic cultures can lead to biofouling and thereby affect algal productivity .',
  'Agglomeration of bFGF at low salt concentrations was a serious problem .',
  "Fermentations carried out at 450-L and 20-L scale to produce Fab ' antibody fragments indicated a serious problem to control levels of dissolved oxygen in the broth due to the large oxygen demand at high cell densities .",
  'Since biofouling organisms are a serious problem in culture , competing with the scallops for food and oxygen , environmentally-friendly methods are required to mitigate the effects of this fouling in the culture systems .',
  'Microbial contamination of alcoholic fermentation processes ( e.g. winemaking and fuel-ethanol production ) is a serious problem for the industry since it may render the product unacceptable and/or reduce its productivity , leading to large economic losses .',
  'Protein haze remains a serious problem for the wine industry and requires costly bentonite treatment , leading to significant wine volume loss .',
  'The fermentation of industrial bacteria encounters a serious problem in continuous culture , i.e. the production traits lose .',
  'However , melanin accumulation during culture represents a serious problem for the purification of erythritol from the fermentation broth .',
  'Biofouling is a serious problem in marine aquaculture and it has a number of negative impacts including increased forces on aquaculture structures and reduced water exchange across nets .',
  'Tartaric instability of wines still represents a serious problem in terms of the commercial value of bottled wines , particularly whites , leading consumers to be suspicious as regards the effective healthiness or wholesomeness of products .',
  'The disposal of bio-waste ( e.g. , Corynebacterium glutamicum ) produced by the fermentation industry is a serious problem and has a negative impact on economic returns .',
  'Contamination of bacteria in large-scale yeast fermentations is a serious problem and a threat to the development of successful biofuel production plants .',
  'This is an off-flavor that is a serious problem for the wine industry .',
  'Acetic acid bacteria ( AAB ) irreversibly spoil wines and represent a serious problem .',
  'Biofouling is a severe problem of any water borne structure .',
  'Brettanomyces bruxellensis spoilage is a serious problem for the wine industry .',
  'Foaming of the culture medium had not been encountered previously , but was a serious problem in pilot scale production due to the very rapid growth of a large volume of L. giganteum .',
  'Grape pomace ( GP ) from Vitis labrusca , the main byproduct from " American table wine " production , is recalcitrant to degradation , and its accumulation is a serious problem with negative environmental impacts .',
  'Cork taint in wine is a serious problem which is exacerbated by the difficulty of its assessment .',
  'It was thought that energy supply is a severe problem for anaerobic fermentation of glycerol to produce succinate .'],
 'biofouling': ['However , the problem with many of the cross-sectional studies of wine expertise that have been published to date is that they simply can not rule out the possibility that those with superior chemosensory abilities end-up gravitating toward a career in wine .',
  'One major problem associated with PBRs however , is that the bacteria usually associated with microalgae in nonaxenic cultures can lead to biofouling and thereby affect algal productivity .',
  'Agglomeration of bFGF at low salt concentrations was a serious problem .',
  "Fermentations carried out at 450-L and 20-L scale to produce Fab ' antibody fragments indicated a serious problem to control levels of dissolved oxygen in the broth due to the large oxygen demand at high cell densities .",
  'Since biofouling organisms are a serious problem in culture , competing with the scallops for food and oxygen , environmentally-friendly methods are required to mitigate the effects of this fouling in the culture systems .',
  'Microbial contamination of alcoholic fermentation processes ( e.g. winemaking and fuel-ethanol production ) is a serious problem for the industry since it may render the product unacceptable and/or reduce its productivity , leading to large economic losses .',
  'Protein haze remains a serious problem for the wine industry and requires costly bentonite treatment , leading to significant wine volume loss .',
  'The fermentation of industrial bacteria encounters a serious problem in continuous culture , i.e. the production traits lose .',
  'However , melanin accumulation during culture represents a serious problem for the purification of erythritol from the fermentation broth .',
  'Biofouling is a serious problem in marine aquaculture and it has a number of negative impacts including increased forces on aquaculture structures and reduced water exchange across nets .',
  'Tartaric instability of wines still represents a serious problem in terms of the commercial value of bottled wines , particularly whites , leading consumers to be suspicious as regards the effective healthiness or wholesomeness of products .',
  'The disposal of bio-waste ( e.g. , Corynebacterium glutamicum ) produced by the fermentation industry is a serious problem and has a negative impact on economic returns .',
  'Contamination of bacteria in large-scale yeast fermentations is a serious problem and a threat to the development of successful biofuel production plants .',
  'This is an off-flavor that is a serious problem for the wine industry .',
  'Acetic acid bacteria ( AAB ) irreversibly spoil wines and represent a serious problem .',
  'Biofouling is a severe problem of any water borne structure .',
  'Brettanomyces bruxellensis spoilage is a serious problem for the wine industry .',
  'Foaming of the culture medium had not been encountered previously , but was a serious problem in pilot scale production due to the very rapid growth of a large volume of L. giganteum .',
  'Grape pomace ( GP ) from Vitis labrusca , the main byproduct from " American table wine " production , is recalcitrant to degradation , and its accumulation is a serious problem with negative environmental impacts .',
  'Cork taint in wine is a serious problem which is exacerbated by the difficulty of its assessment .',
  'It was thought that energy supply is a severe problem for anaerobic fermentation of glycerol to produce succinate .'],
 'wines': ['However , the problem with many of the cross-sectional studies of wine expertise that have been published to date is that they simply can not rule out the possibility that those with superior chemosensory abilities end-up gravitating toward a career in wine .',
  'One major problem associated with PBRs however , is that the bacteria usually associated with microalgae in nonaxenic cultures can lead to biofouling and thereby affect algal productivity .',
  'Agglomeration of bFGF at low salt concentrations was a serious problem .',
  "Fermentations carried out at 450-L and 20-L scale to produce Fab ' antibody fragments indicated a serious problem to control levels of dissolved oxygen in the broth due to the large oxygen demand at high cell densities .",
  'Since biofouling organisms are a serious problem in culture , competing with the scallops for food and oxygen , environmentally-friendly methods are required to mitigate the effects of this fouling in the culture systems .',
  'Microbial contamination of alcoholic fermentation processes ( e.g. winemaking and fuel-ethanol production ) is a serious problem for the industry since it may render the product unacceptable and/or reduce its productivity , leading to large economic losses .',
  'Protein haze remains a serious problem for the wine industry and requires costly bentonite treatment , leading to significant wine volume loss .',
  'The fermentation of industrial bacteria encounters a serious problem in continuous culture , i.e. the production traits lose .',
  'However , melanin accumulation during culture represents a serious problem for the purification of erythritol from the fermentation broth .',
  'Biofouling is a serious problem in marine aquaculture and it has a number of negative impacts including increased forces on aquaculture structures and reduced water exchange across nets .',
  'Tartaric instability of wines still represents a serious problem in terms of the commercial value of bottled wines , particularly whites , leading consumers to be suspicious as regards the effective healthiness or wholesomeness of products .',
  'The disposal of bio-waste ( e.g. , Corynebacterium glutamicum ) produced by the fermentation industry is a serious problem and has a negative impact on economic returns .',
  'Contamination of bacteria in large-scale yeast fermentations is a serious problem and a threat to the development of successful biofuel production plants .',
  'This is an off-flavor that is a serious problem for the wine industry .',
  'Acetic acid bacteria ( AAB ) irreversibly spoil wines and represent a serious problem .',
  'Biofouling is a severe problem of any water borne structure .',
  'Brettanomyces bruxellensis spoilage is a serious problem for the wine industry .',
  'Foaming of the culture medium had not been encountered previously , but was a serious problem in pilot scale production due to the very rapid growth of a large volume of L. giganteum .',
  'Grape pomace ( GP ) from Vitis labrusca , the main byproduct from " American table wine " production , is recalcitrant to degradation , and its accumulation is a serious problem with negative environmental impacts .',
  'Cork taint in wine is a serious problem which is exacerbated by the difficulty of its assessment .',
  'It was thought that energy supply is a severe problem for anaerobic fermentation of glycerol to produce succinate .'],
 'implant': ['A common problem with implants is that bacteria can form biofilms on their surfaces , which can lead to infection and , eventually , to implant rejection .',
  'The major problem associated with the use of antibiotics to treat peri-implantitis is that microorganisms replicate very quickly .',
  'For this reason , post implant infection remains a serious concern among plastic surgeons .',
  'Ventriculoperitoneal shunt infection is a serious clinical problem for which implant removal is considered the treatment of choice .',
  'The implant-associated infection remains a serious problem in clinic .',
  'Health of human beings is subjected to severe threats from the spread of harmful bacteria and the implant-associated infection remains a serious problem in clinic .',
  'Implant-associated infection is a serious problem in orthopaedic surgery .',
  'The infection of orthopedic implantation devices with Staphylococcus has been a serious concern within the biomaterial community .',
  'Bacterial infection of implanted biomaterials is a serious problem that increases health care costs and negatively affects a considerable fraction of orthopedic procedures .',
  'Implant related nosocomial infections are a serious public health concern .',
  'Toxic shock syndrome has been reported to occur following breast implants and is a life-threatening problem requiring immediate removal of the implant .',
  'Bacterial infection is a serious medical problem leading to implant failure .',
  'Implant-associated infection is a common postoperative complication and remains a serious problem in orthopedic surgery .',
  'Although infection rates have decreased with the use of antibiotic-coated implants and other enhancements , the risk of infection is still considered a serious concern in penile implant revision surgeries .',
  'Implant-related bacterial infections remain a serious problem that is not solved yet .',
  'The hospital infections associated with surgical procedures and implants still represents a severe problem to modern society .',
  'Implant-associated infection is a serious problem in orthopaedic surgery .',
  'Implant infection is a serious problem that requires additional patient visits , intensive antibiotic therapy , surgery , or some combination of these .',
  'Local infection near an implant may pose a serious problem for patients .',
  'Infection is a serious problem for patients after implantation surgery , which is difficult to treat with antibiotic therapy .'],
 'implants': ['A common problem with implants is that bacteria can form biofilms on their surfaces , which can lead to infection and , eventually , to implant rejection .',
  'The major problem associated with the use of antibiotics to treat peri-implantitis is that microorganisms replicate very quickly .',
  'For this reason , post implant infection remains a serious concern among plastic surgeons .',
  'Ventriculoperitoneal shunt infection is a serious clinical problem for which implant removal is considered the treatment of choice .',
  'The implant-associated infection remains a serious problem in clinic .',
  'Health of human beings is subjected to severe threats from the spread of harmful bacteria and the implant-associated infection remains a serious problem in clinic .',
  'Implant-associated infection is a serious problem in orthopaedic surgery .',
  'The infection of orthopedic implantation devices with Staphylococcus has been a serious concern within the biomaterial community .',
  'Bacterial infection of implanted biomaterials is a serious problem that increases health care costs and negatively affects a considerable fraction of orthopedic procedures .',
  'Implant related nosocomial infections are a serious public health concern .',
  'Toxic shock syndrome has been reported to occur following breast implants and is a life-threatening problem requiring immediate removal of the implant .',
  'Bacterial infection is a serious medical problem leading to implant failure .',
  'Implant-associated infection is a common postoperative complication and remains a serious problem in orthopedic surgery .',
  'Although infection rates have decreased with the use of antibiotic-coated implants and other enhancements , the risk of infection is still considered a serious concern in penile implant revision surgeries .',
  'Implant-related bacterial infections remain a serious problem that is not solved yet .',
  'The hospital infections associated with surgical procedures and implants still represents a severe problem to modern society .',
  'Implant-associated infection is a serious problem in orthopaedic surgery .',
  'Implant infection is a serious problem that requires additional patient visits , intensive antibiotic therapy , surgery , or some combination of these .',
  'Local infection near an implant may pose a serious problem for patients .',
  'Infection is a serious problem for patients after implantation surgery , which is difficult to treat with antibiotic therapy .'],
 'orthopedic': ['A common problem with implants is that bacteria can form biofilms on their surfaces , which can lead to infection and , eventually , to implant rejection .',
  'The major problem associated with the use of antibiotics to treat peri-implantitis is that microorganisms replicate very quickly .',
  'For this reason , post implant infection remains a serious concern among plastic surgeons .',
  'Ventriculoperitoneal shunt infection is a serious clinical problem for which implant removal is considered the treatment of choice .',
  'The implant-associated infection remains a serious problem in clinic .',
  'Health of human beings is subjected to severe threats from the spread of harmful bacteria and the implant-associated infection remains a serious problem in clinic .',
  'Implant-associated infection is a serious problem in orthopaedic surgery .',
  'The infection of orthopedic implantation devices with Staphylococcus has been a serious concern within the biomaterial community .',
  'Bacterial infection of implanted biomaterials is a serious problem that increases health care costs and negatively affects a considerable fraction of orthopedic procedures .',
  'Implant related nosocomial infections are a serious public health concern .',
  'Toxic shock syndrome has been reported to occur following breast implants and is a life-threatening problem requiring immediate removal of the implant .',
  'Bacterial infection is a serious medical problem leading to implant failure .',
  'Implant-associated infection is a common postoperative complication and remains a serious problem in orthopedic surgery .',
  'Although infection rates have decreased with the use of antibiotic-coated implants and other enhancements , the risk of infection is still considered a serious concern in penile implant revision surgeries .',
  'Implant-related bacterial infections remain a serious problem that is not solved yet .',
  'The hospital infections associated with surgical procedures and implants still represents a severe problem to modern society .',
  'Implant-associated infection is a serious problem in orthopaedic surgery .',
  'Implant infection is a serious problem that requires additional patient visits , intensive antibiotic therapy , surgery , or some combination of these .',
  'Local infection near an implant may pose a serious problem for patients .',
  'Infection is a serious problem for patients after implantation surgery , which is difficult to treat with antibiotic therapy .'],
 'antifungal': ['The major problem with flucytosine is that many strains of Candida are initially resistant , and some strains may develop secondary resistance during the course of therapy .',
  'Miconazole nitrate is an antifungal drug with a drawback of poor skin-penetration in the treatment of deep seated fungal skin infections .',
  'The substantial increase in the rate of azole resistant Candida spp . yeast infections has become a serious treatment problem requiring new and more active antifungal agents .',
  'As a consequence of prolonged application of antifungal drugs , the treatment failures combined with multidrug-resistance have become a serious problem in clinical practice .',
  'In addition , intrinsic or acquired antifungal resistance may pose a serious problem to antifungal therapy .',
  'Fungal diseases are currently a serious public health problem , due to the limited number of fact-based effective principles , and the emergence of resistant strains to the polyenic antifungals .',
  'Resistance to the limited number of available antifungal drugs is a serious problem in the treatment of Candida albicans .',
  'The increasing resistance to antifungal drugs especially of these new emerging pathogens is a severe problem for managing these IFIs .',
  'The rapidly developing resistance of fungi to antifungal drugs is a serious health problem .',
  'In contrast the occurrence of strains of C. albicans resistant to 5-fluorocytosine is a serious clinical problem .',
  'Limited spectrum of antifungal activity of currently available antifungals and emergence of resistance has become a serious problem .',
  'To date resistance among individual yeast species or strains has only been a serious problem with flucytosine .',
  'Candidiasis has long been a serious human health problem , and novel antifungal approaches are greatly needed .',
  'Although numerous antifungal agents are available , IFI remains a serious problem because of obstacles to timely diagnosis and high morbidity and mortality rates associated with such infection .',
  'Acquired azole resistance is a serious clinical problem that is often associated with the appearance of aneuploidy and , in particular , with the formation of an isochromosome [ i(5L ) ] in the fungal opportunist Candida albicans .',
  'Multidrug resistance may pose a serious problem to antifungal therapy .',
  'Moreover , antifungal therapy is expensive , treatment periods can range from weeks to years , and toxicity is also a serious concern .',
  'With the limited availability of antifungal drugs and the increasing incidence of opportunistic fungal infections , the emergence of drug resistance in fungal pathogens poses a serious public health concern .',
  'In spite of the development of new antifungal drugs , epidemiological studies have shown that resistance to antifungal drugs among Candida isolates is becoming a serious problem .',
  'The increasing clinical and microbiologic resistance of Candida spp . isolates to several antifungal agents is becoming a serious problem .',
  'In the recent years , there has been a marked increase in the incidence of treatment failures in candidiasis patients receiving long-term antifungal therapy , which has posed a serious problem in its successful use in chemotherapy .',
  'Nevertheless , antifungal resistant pathogens have increased during the past decade , becoming a serious concern .',
  'C. albicans resistance to antifungal drugs is a severe problem in patients receiving prolonged therapy .',
  'In addition to microbiological resistance to existing antifungal drugs , the large number of unexplained treatment failures is a serious concern .',
  'The widespread emergence of antifungal drug resistance poses a severe clinical problem .',
  'In spite of the development of new antifungal drugs , epidemiological studies have shown that resistance to antifungal drugs in C. albicans strains is becoming a serious problem .',
  'The lack of antifungal drugs with novel modes of action reaching the clinic is a serious concern .',
  'The problem of resistance to azole class of antifungals is a serious cause of concern to the medical fraternity and thus there is an urgent need to identify non-azole scaffolds with high affinity for lanosterol 14α-demethylase ( CYP51 ) .',
  'The development of resistance to azole antifungals used in the treatment of fungal infections can be a serious medical problem .',
  'Antifungal resistance is a serious problem in clinical infections .',
  'Azole-resistant A. fumigatus is rapidly increasing and becoming a serious concern .',
  'Medical triazoles compounds have structural similarity with triazole fungicide compounds in agriculture , therefore , resistance development through exposure to triazole fungicide compounds in the environment is important but it sounds there is not a serious health problem in drug resistance in environmental isolates in Iran .',
  'Current therapy is based on the administration of antifungal drugs , but the occurrence of resistant strains to the most common molecules has become a serious health-care problem .'],
 'azole': ['The major problem with flucytosine is that many strains of Candida are initially resistant , and some strains may develop secondary resistance during the course of therapy .',
  'Miconazole nitrate is an antifungal drug with a drawback of poor skin-penetration in the treatment of deep seated fungal skin infections .',
  'The substantial increase in the rate of azole resistant Candida spp . yeast infections has become a serious treatment problem requiring new and more active antifungal agents .',
  'As a consequence of prolonged application of antifungal drugs , the treatment failures combined with multidrug-resistance have become a serious problem in clinical practice .',
  'In addition , intrinsic or acquired antifungal resistance may pose a serious problem to antifungal therapy .',
  'Fungal diseases are currently a serious public health problem , due to the limited number of fact-based effective principles , and the emergence of resistant strains to the polyenic antifungals .',
  'Resistance to the limited number of available antifungal drugs is a serious problem in the treatment of Candida albicans .',
  'The increasing resistance to antifungal drugs especially of these new emerging pathogens is a severe problem for managing these IFIs .',
  'The rapidly developing resistance of fungi to antifungal drugs is a serious health problem .',
  'In contrast the occurrence of strains of C. albicans resistant to 5-fluorocytosine is a serious clinical problem .',
  'Limited spectrum of antifungal activity of currently available antifungals and emergence of resistance has become a serious problem .',
  'To date resistance among individual yeast species or strains has only been a serious problem with flucytosine .',
  'Candidiasis has long been a serious human health problem , and novel antifungal approaches are greatly needed .',
  'Although numerous antifungal agents are available , IFI remains a serious problem because of obstacles to timely diagnosis and high morbidity and mortality rates associated with such infection .',
  'Acquired azole resistance is a serious clinical problem that is often associated with the appearance of aneuploidy and , in particular , with the formation of an isochromosome [ i(5L ) ] in the fungal opportunist Candida albicans .',
  'Multidrug resistance may pose a serious problem to antifungal therapy .',
  'Moreover , antifungal therapy is expensive , treatment periods can range from weeks to years , and toxicity is also a serious concern .',
  'With the limited availability of antifungal drugs and the increasing incidence of opportunistic fungal infections , the emergence of drug resistance in fungal pathogens poses a serious public health concern .',
  'In spite of the development of new antifungal drugs , epidemiological studies have shown that resistance to antifungal drugs among Candida isolates is becoming a serious problem .',
  'The increasing clinical and microbiologic resistance of Candida spp . isolates to several antifungal agents is becoming a serious problem .',
  'In the recent years , there has been a marked increase in the incidence of treatment failures in candidiasis patients receiving long-term antifungal therapy , which has posed a serious problem in its successful use in chemotherapy .',
  'Nevertheless , antifungal resistant pathogens have increased during the past decade , becoming a serious concern .',
  'C. albicans resistance to antifungal drugs is a severe problem in patients receiving prolonged therapy .',
  'In addition to microbiological resistance to existing antifungal drugs , the large number of unexplained treatment failures is a serious concern .',
  'The widespread emergence of antifungal drug resistance poses a severe clinical problem .',
  'In spite of the development of new antifungal drugs , epidemiological studies have shown that resistance to antifungal drugs in C. albicans strains is becoming a serious problem .',
  'The lack of antifungal drugs with novel modes of action reaching the clinic is a serious concern .',
  'The problem of resistance to azole class of antifungals is a serious cause of concern to the medical fraternity and thus there is an urgent need to identify non-azole scaffolds with high affinity for lanosterol 14α-demethylase ( CYP51 ) .',
  'The development of resistance to azole antifungals used in the treatment of fungal infections can be a serious medical problem .',
  'Antifungal resistance is a serious problem in clinical infections .',
  'Azole-resistant A. fumigatus is rapidly increasing and becoming a serious concern .',
  'Medical triazoles compounds have structural similarity with triazole fungicide compounds in agriculture , therefore , resistance development through exposure to triazole fungicide compounds in the environment is important but it sounds there is not a serious health problem in drug resistance in environmental isolates in Iran .',
  'Current therapy is based on the administration of antifungal drugs , but the occurrence of resistant strains to the most common molecules has become a serious health-care problem .'],
 'conservation': ['The main problem to deal with is that monitoring programmes intended for the assessment of marine environmental quality and for human health safety usually apply different approaches and methodologies , and even different tissues are analysed in some species ( mainly fish ) .',
  'Adulteration of the high-value silver pomfret ( Pampus argenteus ) is a serious problem worldwide , necessitating accurate identification and quantification of the species .',
  'The decline of habitat for elephants due to expanding human activity is a serious conservation problem .',
  'This raises a serious concern because these fishes are consumed by the local populations and hence would ultimately affect human health .',
  'At present , intensive fish culture does not pose a serious animal welfare problem in Germany .',
  'Fish invasion has become a serious environmental and economic damage , and obtained a priority concern by the conservation ichthyologists and land managers .',
  'Possible escape of crossbred specimens from pisciculture stations is a serious environmental concern .',
  'Diarrheic Shellfish Poisoning toxins ( DST ) are a severe health risk to shellfish consumers and can be a major problem for the shellfish industry .',
  'The overabundance of large herbivores is now recognized as a serious ecological problem .',
  'If effective control measures are not implemented , precipitous declines in bat populations are likely , particularly in cave-dense regions that constitute the main geographic corridors of the USA , a serious concern for bat conservation .',
  '1 . Selective harvesting is acknowledged as a serious concern in efforts to conserve wild animal populations .',
  'The African elephant reproduces so efficiently in the wild that overpopulation is now a serious problem in some game parks in Zimbabwe , Botswana and South Africa .',
  'The hazard to intoxication is not as common in purchased seafood , which is more stringently regulated , yet still is a serious problem .',
  'Erosion of traditional knowledge and practice is a serious and accelerating problem , but quantitative work on traditional knowledge loss and its importance to biodiversity conservation is lacking .',
  'Degradation of reservoir fish habitat has become a serious concern .',
  'At the time , this episode presented a major health risk to the community as a whole and has subsequently posed a serious economic problem for the oyster farming and distributing industry .',
  '  Childhood shellfish allergy is a serious and underdiagnosed problem in the United States .',
  'Some functional alterations were detected by the fish-based index , but the decline of functional redundancy was not reflected , highlighting a serious concern for management .',
  'This insufficient anti-predator response has led to widespread population declines among many island species exposed to novel predators , and has become a serious conservation problem .',
  'In September 2014 , contamination of boiled and dried whitebait products with pufferfish juveniles became a serious food safety concern , as tiger pufferfish Takifugu rubripes juveniles are toxic and contain tetrodotoxin ( TTX ) .',
  'This is a serious problem , particularly considering that populations of several commercially exploited fishes are declining and some exhibit recruitment problems .',
  'Human-induced eutrophication is a serious environmental problem that constrains visual communication and influences the mate choice process in fishes .',
  'However , the decreases in eel resources have been a serious concern in recent years .',
  'While fishers perceive a serious negative impact of fishing activities on sea turtles in the San Ignacio-Navachiste-Macapule area , they do not see themselves individually as part of the problem .',
  'It is a vexing problem to achieve a consensus about the proper scientific way to assess population viability for habitat conservation plans .',
  '[ The fish bowl is a serious problem ] .',
  'Crop raiding by wild herbivores close to an area of protected wildlife is a serious problem that can potentially undermine conservation efforts .',
  'Type I allergy to fish is a severe health problem in countries in which a large percentage of the population derive income from fishing .',
  'Paralytic shellfish poisoning is a serious public health concern throughout the world .',
  "This OA effect is a serious concern in SE Asia , which produces > 80 % of the world 's oysters .",
  'The severity of disturbances and the possibility of a serious behavioural problem for fish across the globe is cause for concern .',
  'Oysters are widely consumed seafood , but their shells impose a serious environmental problem .',
  'Overexploitation of commercially beneficial fish is a serious ecological problem around the world .',
  'Most roadkilled species were common generalists , but there were also relatively high roadkill numbers of threatened and endangered species ( 4.3 % of the data ) , which is a serious conservation concern .',
  'The contamination of fish and shellfish has been a serious problem for the Japanese , who consume a large amount of fish in their diet .',
  'However , they are recognized as one of the most common food allergens and pose a serious health problem in countries where fish consumption is high .',
  'Destructive fishing methods such as drag nets and dynamite fishing pose a serious problem as they destroy important habitats for fish and other organisms , and there is a long-term trend of overharvested fishery resources .',
  'Human habituation of large carnivores is becoming a serious problem that generates human-wildlife conflict , which often results in the removal of animals as nuisances .',
  'As oysters are eaten raw in Japan , their contamination with the non-bacterial agent of gastroenteritis has become a serious health problem .',
  'This raises a serious concern as these fishes are consumed by the local population which would ultimately affect human health .',
  'Wildlife-related accidents , especially deer-vehicle accidents , pose a serious problem for road safety and animal protection in many countries .',
  'Deer pressure on forest regeneration constitutes a serious problem in commercial forests in the northern hemisphere due to the increase in deer populations .',
  'A serious toxicological problem affecting many countries of the world , mild cases of this poisoning can occur within 30 minutes while in extreme cases , death through respiratory paralysis may occur within 2 - 24 hrs of ingestion of intoxicated shellfish .',
  'Wildlife mortality caused by vehicles is a serious conservation and economic problem as collisions with large mammals are global , pervasive and increasing .',
  'These recoveries represent important conservation successes but present a serious conservation problem when the recovering mammals are predators of species of conservation concern .',
  'Fish allergy constitutes a severe problem worldwide .',
  'Food allergies represent a serious public health problem worldwide with fish being one of the top eight more allergenic foods .',
  'Our projections indicate that up to 86 % of thermo-suitable habitat could be lost by 2085 , a serious conservation concern for the species .'],
 'fish': ['The main problem to deal with is that monitoring programmes intended for the assessment of marine environmental quality and for human health safety usually apply different approaches and methodologies , and even different tissues are analysed in some species ( mainly fish ) .',
  'Adulteration of the high-value silver pomfret ( Pampus argenteus ) is a serious problem worldwide , necessitating accurate identification and quantification of the species .',
  'The decline of habitat for elephants due to expanding human activity is a serious conservation problem .',
  'This raises a serious concern because these fishes are consumed by the local populations and hence would ultimately affect human health .',
  'At present , intensive fish culture does not pose a serious animal welfare problem in Germany .',
  'Fish invasion has become a serious environmental and economic damage , and obtained a priority concern by the conservation ichthyologists and land managers .',
  'Possible escape of crossbred specimens from pisciculture stations is a serious environmental concern .',
  'Diarrheic Shellfish Poisoning toxins ( DST ) are a severe health risk to shellfish consumers and can be a major problem for the shellfish industry .',
  'The overabundance of large herbivores is now recognized as a serious ecological problem .',
  'If effective control measures are not implemented , precipitous declines in bat populations are likely , particularly in cave-dense regions that constitute the main geographic corridors of the USA , a serious concern for bat conservation .',
  '1 . Selective harvesting is acknowledged as a serious concern in efforts to conserve wild animal populations .',
  'The African elephant reproduces so efficiently in the wild that overpopulation is now a serious problem in some game parks in Zimbabwe , Botswana and South Africa .',
  'The hazard to intoxication is not as common in purchased seafood , which is more stringently regulated , yet still is a serious problem .',
  'Erosion of traditional knowledge and practice is a serious and accelerating problem , but quantitative work on traditional knowledge loss and its importance to biodiversity conservation is lacking .',
  'Degradation of reservoir fish habitat has become a serious concern .',
  'At the time , this episode presented a major health risk to the community as a whole and has subsequently posed a serious economic problem for the oyster farming and distributing industry .',
  '  Childhood shellfish allergy is a serious and underdiagnosed problem in the United States .',
  'Some functional alterations were detected by the fish-based index , but the decline of functional redundancy was not reflected , highlighting a serious concern for management .',
  'This insufficient anti-predator response has led to widespread population declines among many island species exposed to novel predators , and has become a serious conservation problem .',
  'In September 2014 , contamination of boiled and dried whitebait products with pufferfish juveniles became a serious food safety concern , as tiger pufferfish Takifugu rubripes juveniles are toxic and contain tetrodotoxin ( TTX ) .',
  'This is a serious problem , particularly considering that populations of several commercially exploited fishes are declining and some exhibit recruitment problems .',
  'Human-induced eutrophication is a serious environmental problem that constrains visual communication and influences the mate choice process in fishes .',
  'However , the decreases in eel resources have been a serious concern in recent years .',
  'While fishers perceive a serious negative impact of fishing activities on sea turtles in the San Ignacio-Navachiste-Macapule area , they do not see themselves individually as part of the problem .',
  'It is a vexing problem to achieve a consensus about the proper scientific way to assess population viability for habitat conservation plans .',
  '[ The fish bowl is a serious problem ] .',
  'Crop raiding by wild herbivores close to an area of protected wildlife is a serious problem that can potentially undermine conservation efforts .',
  'Type I allergy to fish is a severe health problem in countries in which a large percentage of the population derive income from fishing .',
  'Paralytic shellfish poisoning is a serious public health concern throughout the world .',
  "This OA effect is a serious concern in SE Asia , which produces > 80 % of the world 's oysters .",
  'The severity of disturbances and the possibility of a serious behavioural problem for fish across the globe is cause for concern .',
  'Oysters are widely consumed seafood , but their shells impose a serious environmental problem .',
  'Overexploitation of commercially beneficial fish is a serious ecological problem around the world .',
  'Most roadkilled species were common generalists , but there were also relatively high roadkill numbers of threatened and endangered species ( 4.3 % of the data ) , which is a serious conservation concern .',
  'The contamination of fish and shellfish has been a serious problem for the Japanese , who consume a large amount of fish in their diet .',
  'However , they are recognized as one of the most common food allergens and pose a serious health problem in countries where fish consumption is high .',
  'Destructive fishing methods such as drag nets and dynamite fishing pose a serious problem as they destroy important habitats for fish and other organisms , and there is a long-term trend of overharvested fishery resources .',
  'Human habituation of large carnivores is becoming a serious problem that generates human-wildlife conflict , which often results in the removal of animals as nuisances .',
  'As oysters are eaten raw in Japan , their contamination with the non-bacterial agent of gastroenteritis has become a serious health problem .',
  'This raises a serious concern as these fishes are consumed by the local population which would ultimately affect human health .',
  'Wildlife-related accidents , especially deer-vehicle accidents , pose a serious problem for road safety and animal protection in many countries .',
  'Deer pressure on forest regeneration constitutes a serious problem in commercial forests in the northern hemisphere due to the increase in deer populations .',
  'A serious toxicological problem affecting many countries of the world , mild cases of this poisoning can occur within 30 minutes while in extreme cases , death through respiratory paralysis may occur within 2 - 24 hrs of ingestion of intoxicated shellfish .',
  'Wildlife mortality caused by vehicles is a serious conservation and economic problem as collisions with large mammals are global , pervasive and increasing .',
  'These recoveries represent important conservation successes but present a serious conservation problem when the recovering mammals are predators of species of conservation concern .',
  'Fish allergy constitutes a severe problem worldwide .',
  'Food allergies represent a serious public health problem worldwide with fish being one of the top eight more allergenic foods .',
  'Our projections indicate that up to 86 % of thermo-suitable habitat could be lost by 2085 , a serious conservation concern for the species .'],
 'victimization': ["One problem with this reporting is that the victim 's reports of bullying may become overshadowed by the bully 's reports of victim incompetence , resulting in the victim experiencing further victimization .",
  'Although bullying is recognized as a serious problem among adolescents , more information is needed regarding bullying within the context of physical education .',
  'School bullying is a serious problem among teenagers .',
  'Bullying victimization in school settings is a serious problem in many countries including the United States .',
  'Despite existing efforts to prevent bullying , research suggests that bullying remains a serious and common problem across the United States .',
  'Bullying is a serious public health concern across the globe .',
  "Bullying is a severe public health problem , and bystanders ' reactions are a key variable in its perpetration and maintenance .",
  'Psychologists recognize homophobic bullying as a serious problem for young lesbians and gay men ; however , when it comes to children in lesbian and gay households the issue is not so clear cut .',
  'School bullying is a serious social problem that results in potentially severe and long lasting consequences for youth , parents , teachers , and school officials .',
  'Bullying victimization in school students is a serious public health concern and has been linked to a wide range of mental health problems .',
  'School bullying is a serious , worldwide problem which is not easily counteracted .',
  'School bullying continues to be a serious problem around the world .',
  'First , does the public perceive bullying as a serious problem and judge schools-primary , secondary , and postsecondary-as safe or unsafe ?',
  'Irrespective of bullying status , delinquency is a serious problem for urban adolescents who are bullies , victims , or bully/victims .',
  'Violence and bullying in the school setting are a serious social and health problem that have created great alarm in the last few years .',
  'Bullying is a serious public health problem , and many studies have examined the effect of school-based anti-bullying programs .',
  'Bullying has been shown to be a serious problem amongst school children , but few studies have been population-based and included pre-school children .',
  'Bullying is a serious problem in schools in Turkey and is a matter of recent concern .',
  'School bullying is a serious problem affecting the victims in their daily lives at school .',
  'Bullying is a serious public health problem that may include verbal or physical injury as well as social isolation or exclusion .',
  'Bullying among youth is recognized as a serious student problem , especially in middle school .',
  'Bullying victimization among Chinese school-aged children has recently been recognized as a serious problem .',
  'Bullying and victimization behaviors are a serious problem for students , peers , parents , and school teachers .',
  'Bullying is a serious public health concern remarkably common among youth .',
  'Bullying is a serious public health concern that is associated with significant negative mental , social , and physical outcomes .',
  'Bullying is a serious problem .',
  'Bullying is a serious problem for schools , parents , and public-policymakers alike .'],
 'cisplatin': ['A major problem with the strategy followed in this protocol was that patients whose tumors had failed to respond to cisplatin-based regimens were often too ill to tolerate additional cisplatin , particularly when accompanied by nifedipine-associated hypotension .',
  'Acquired drug resistance is a major drawback of using cisplatin in the treatment of cancer ; however , platinum analogs containing the 1,2-diaminocyclohexane ( DACH ) ligand can overcome this resistance .',
  'Acquired resistance is a main drawback of using cisplatin in cancer chemotherapy ; however , analogs containing the 1,2-diaminocyclohexane ( DACH ) ligand can overcome this resistance .',
  'In summary , ammine/amine platinum ( II ) analogs have demonstrated promise at the preclinical level in their ability to circumvent acquired resistance , which is a major drawback of cisplatin use in treating cancer .',
  'Acquired drug resistance is a major drawback of using cisplatin in the treatment of cancer ; however , analogs containing the 1,2-diaminocyclohexane ( DACH ) ligand can overcome this resistance .',
  'Whereas cisplatin ( CDDP ) has strongly an effectiveness for ovarian cancers , but the drug resistance of cancer cells for CDDP was causing a serious problem .',
  'The resistance of head and neck squamous carcinoma cells ( HNSCCs ) to cis-Diamminedichloroplatinum(II ) ( CDDP ) , which is widely used for the treatment of many malignancies , is a serious problem in the clinic .',
  'In this sense , cisplatin ( CDDP ) is one of the most drugs used in the treatment of OS but drug resistance to CDDP appears as a serious problem in the use of this drug in the treatment of OS .',
  'Cisplatin resistance is still a serious problem in the clinic .',
  'Emesis after the administration of cisplatin is a severe complication , and its treatment is an important problem clinically .',
  'Cisplatin is the most important chemotherapeutic agent involved in treatment of head and neck squamous cell carcinoma ( HNSCC ) , but cisplatin resistance in HNSCC is still a serious problem in clinic .',
  'Cisplatin resistance is a serious problem in cancer treatment .',
  'Acquired platinum resistance is a serious problem in the treatment of ovarian carcinomas .',
  'Resistance to platinum-based chemotherapy frequently poses a serious problem in the treatment of head and neck squamous cell carcinoma .',
  'However , the development of resistance to cisplatin represents a serious clinical problem .',
  'Stomatitis caused by a combined chemotherapy with 5-fluorouracil ( 5-FU ) and cisplatin ( CDDP ) is a serious problem in the course of treatment for patients with oral carcinoma .',
  'Cisplatin-induced acute kidney injury is a serious problem in cancer patients during treatment of solid tumors .'],
 'cddp': ['A major problem with the strategy followed in this protocol was that patients whose tumors had failed to respond to cisplatin-based regimens were often too ill to tolerate additional cisplatin , particularly when accompanied by nifedipine-associated hypotension .',
  'Acquired drug resistance is a major drawback of using cisplatin in the treatment of cancer ; however , platinum analogs containing the 1,2-diaminocyclohexane ( DACH ) ligand can overcome this resistance .',
  'Acquired resistance is a main drawback of using cisplatin in cancer chemotherapy ; however , analogs containing the 1,2-diaminocyclohexane ( DACH ) ligand can overcome this resistance .',
  'In summary , ammine/amine platinum ( II ) analogs have demonstrated promise at the preclinical level in their ability to circumvent acquired resistance , which is a major drawback of cisplatin use in treating cancer .',
  'Acquired drug resistance is a major drawback of using cisplatin in the treatment of cancer ; however , analogs containing the 1,2-diaminocyclohexane ( DACH ) ligand can overcome this resistance .',
  'Whereas cisplatin ( CDDP ) has strongly an effectiveness for ovarian cancers , but the drug resistance of cancer cells for CDDP was causing a serious problem .',
  'The resistance of head and neck squamous carcinoma cells ( HNSCCs ) to cis-Diamminedichloroplatinum(II ) ( CDDP ) , which is widely used for the treatment of many malignancies , is a serious problem in the clinic .',
  'In this sense , cisplatin ( CDDP ) is one of the most drugs used in the treatment of OS but drug resistance to CDDP appears as a serious problem in the use of this drug in the treatment of OS .',
  'Cisplatin resistance is still a serious problem in the clinic .',
  'Emesis after the administration of cisplatin is a severe complication , and its treatment is an important problem clinically .',
  'Cisplatin is the most important chemotherapeutic agent involved in treatment of head and neck squamous cell carcinoma ( HNSCC ) , but cisplatin resistance in HNSCC is still a serious problem in clinic .',
  'Cisplatin resistance is a serious problem in cancer treatment .',
  'Acquired platinum resistance is a serious problem in the treatment of ovarian carcinomas .',
  'Resistance to platinum-based chemotherapy frequently poses a serious problem in the treatment of head and neck squamous cell carcinoma .',
  'However , the development of resistance to cisplatin represents a serious clinical problem .',
  'Stomatitis caused by a combined chemotherapy with 5-fluorouracil ( 5-FU ) and cisplatin ( CDDP ) is a serious problem in the course of treatment for patients with oral carcinoma .',
  'Cisplatin-induced acute kidney injury is a serious problem in cancer patients during treatment of solid tumors .'],
 'diaminocyclohexane': ['A major problem with the strategy followed in this protocol was that patients whose tumors had failed to respond to cisplatin-based regimens were often too ill to tolerate additional cisplatin , particularly when accompanied by nifedipine-associated hypotension .',
  'Acquired drug resistance is a major drawback of using cisplatin in the treatment of cancer ; however , platinum analogs containing the 1,2-diaminocyclohexane ( DACH ) ligand can overcome this resistance .',
  'Acquired resistance is a main drawback of using cisplatin in cancer chemotherapy ; however , analogs containing the 1,2-diaminocyclohexane ( DACH ) ligand can overcome this resistance .',
  'In summary , ammine/amine platinum ( II ) analogs have demonstrated promise at the preclinical level in their ability to circumvent acquired resistance , which is a major drawback of cisplatin use in treating cancer .',
  'Acquired drug resistance is a major drawback of using cisplatin in the treatment of cancer ; however , analogs containing the 1,2-diaminocyclohexane ( DACH ) ligand can overcome this resistance .',
  'Whereas cisplatin ( CDDP ) has strongly an effectiveness for ovarian cancers , but the drug resistance of cancer cells for CDDP was causing a serious problem .',
  'The resistance of head and neck squamous carcinoma cells ( HNSCCs ) to cis-Diamminedichloroplatinum(II ) ( CDDP ) , which is widely used for the treatment of many malignancies , is a serious problem in the clinic .',
  'In this sense , cisplatin ( CDDP ) is one of the most drugs used in the treatment of OS but drug resistance to CDDP appears as a serious problem in the use of this drug in the treatment of OS .',
  'Cisplatin resistance is still a serious problem in the clinic .',
  'Emesis after the administration of cisplatin is a severe complication , and its treatment is an important problem clinically .',
  'Cisplatin is the most important chemotherapeutic agent involved in treatment of head and neck squamous cell carcinoma ( HNSCC ) , but cisplatin resistance in HNSCC is still a serious problem in clinic .',
  'Cisplatin resistance is a serious problem in cancer treatment .',
  'Acquired platinum resistance is a serious problem in the treatment of ovarian carcinomas .',
  'Resistance to platinum-based chemotherapy frequently poses a serious problem in the treatment of head and neck squamous cell carcinoma .',
  'However , the development of resistance to cisplatin represents a serious clinical problem .',
  'Stomatitis caused by a combined chemotherapy with 5-fluorouracil ( 5-FU ) and cisplatin ( CDDP ) is a serious problem in the course of treatment for patients with oral carcinoma .',
  'Cisplatin-induced acute kidney injury is a serious problem in cancer patients during treatment of solid tumors .'],
 'ligand': ['A major problem with the strategy followed in this protocol was that patients whose tumors had failed to respond to cisplatin-based regimens were often too ill to tolerate additional cisplatin , particularly when accompanied by nifedipine-associated hypotension .',
  'Acquired drug resistance is a major drawback of using cisplatin in the treatment of cancer ; however , platinum analogs containing the 1,2-diaminocyclohexane ( DACH ) ligand can overcome this resistance .',
  'Acquired resistance is a main drawback of using cisplatin in cancer chemotherapy ; however , analogs containing the 1,2-diaminocyclohexane ( DACH ) ligand can overcome this resistance .',
  'In summary , ammine/amine platinum ( II ) analogs have demonstrated promise at the preclinical level in their ability to circumvent acquired resistance , which is a major drawback of cisplatin use in treating cancer .',
  'Acquired drug resistance is a major drawback of using cisplatin in the treatment of cancer ; however , analogs containing the 1,2-diaminocyclohexane ( DACH ) ligand can overcome this resistance .',
  'Whereas cisplatin ( CDDP ) has strongly an effectiveness for ovarian cancers , but the drug resistance of cancer cells for CDDP was causing a serious problem .',
  'The resistance of head and neck squamous carcinoma cells ( HNSCCs ) to cis-Diamminedichloroplatinum(II ) ( CDDP ) , which is widely used for the treatment of many malignancies , is a serious problem in the clinic .',
  'In this sense , cisplatin ( CDDP ) is one of the most drugs used in the treatment of OS but drug resistance to CDDP appears as a serious problem in the use of this drug in the treatment of OS .',
  'Cisplatin resistance is still a serious problem in the clinic .',
  'Emesis after the administration of cisplatin is a severe complication , and its treatment is an important problem clinically .',
  'Cisplatin is the most important chemotherapeutic agent involved in treatment of head and neck squamous cell carcinoma ( HNSCC ) , but cisplatin resistance in HNSCC is still a serious problem in clinic .',
  'Cisplatin resistance is a serious problem in cancer treatment .',
  'Acquired platinum resistance is a serious problem in the treatment of ovarian carcinomas .',
  'Resistance to platinum-based chemotherapy frequently poses a serious problem in the treatment of head and neck squamous cell carcinoma .',
  'However , the development of resistance to cisplatin represents a serious clinical problem .',
  'Stomatitis caused by a combined chemotherapy with 5-fluorouracil ( 5-FU ) and cisplatin ( CDDP ) is a serious problem in the course of treatment for patients with oral carcinoma .',
  'Cisplatin-induced acute kidney injury is a serious problem in cancer patients during treatment of solid tumors .'],
 'nerve': ['The problem with calling it by this name is that it surrounds a true mixed peripheral nerve and not a radicule ( root ) .',
  'Common peroneal nerve ( CPN ) injury following a knee dislocation is a serious problem , and an optimal treatment is yet to be established .',
  'Peripheral nerve regeneration is a serious clinical problem .',
  'Neuromas are a debilitating peripheral nerve problem due to aberrant axon sprouting and inflammation after nerve injury .',
  'Peripheral nerve involvement has been described at alarming rates in some studies , which increases the chance of deformities , a serious problem , especially if one considers the age of these patients .',
  'Nerve injury , especially the large-size nerve damage , is a serious problem affecting millions of people .',
  'Perioperative peripheral neuropathy in abdominal free flap breast reconstruction is a preventable problem .',
  'Peripheral nerves are exposed to physical injuries usually caused by trauma that may lead to a significant loss of sensory or motor functions and is considered as a serious health problem for societies today .',
  'Poor muscle and nerve functional recovery after nerve damage is a serious clinical problem , particularly if there is prolonged delay before nerve-muscle contact is reestablished .',
  'Peripheral nerve injury is a serious clinical problem to be solved .',
  'Peripheral nerve injury ( PNI ) is a serious clinical health problem caused by the damage of peripheral nerves which results in neurological deficits and permanent disability .',
  'Peripheral nerve injury is a serious medical problem and severely affects normal life of patient .',
  'Peroneal nerve palsy after knee dislocation is a serious problem , and neurolysis at the time of knee reconstruction does not always result in return of peroneal nerve function .',
  'Knee dislocation with a common peroneal nerve injury is a serious problem .',
  "Peripheral nerve injury is a serious problem affecting significantly patients ' life .",
  'Peroneal nerve palsy following knee dislocation is a serious problem , and neurolysis at the time of knee reconstruction does not always result in return of peroneal nerve function .',
  'Peripheral nerve injury ( PNI ) is a serious public health problem that is linked with motor , sensory and autonomic deficits .'],
 'peroneal': ['The problem with calling it by this name is that it surrounds a true mixed peripheral nerve and not a radicule ( root ) .',
  'Common peroneal nerve ( CPN ) injury following a knee dislocation is a serious problem , and an optimal treatment is yet to be established .',
  'Peripheral nerve regeneration is a serious clinical problem .',
  'Neuromas are a debilitating peripheral nerve problem due to aberrant axon sprouting and inflammation after nerve injury .',
  'Peripheral nerve involvement has been described at alarming rates in some studies , which increases the chance of deformities , a serious problem , especially if one considers the age of these patients .',
  'Nerve injury , especially the large-size nerve damage , is a serious problem affecting millions of people .',
  'Perioperative peripheral neuropathy in abdominal free flap breast reconstruction is a preventable problem .',
  'Peripheral nerves are exposed to physical injuries usually caused by trauma that may lead to a significant loss of sensory or motor functions and is considered as a serious health problem for societies today .',
  'Poor muscle and nerve functional recovery after nerve damage is a serious clinical problem , particularly if there is prolonged delay before nerve-muscle contact is reestablished .',
  'Peripheral nerve injury is a serious clinical problem to be solved .',
  'Peripheral nerve injury ( PNI ) is a serious clinical health problem caused by the damage of peripheral nerves which results in neurological deficits and permanent disability .',
  'Peripheral nerve injury is a serious medical problem and severely affects normal life of patient .',
  'Peroneal nerve palsy after knee dislocation is a serious problem , and neurolysis at the time of knee reconstruction does not always result in return of peroneal nerve function .',
  'Knee dislocation with a common peroneal nerve injury is a serious problem .',
  "Peripheral nerve injury is a serious problem affecting significantly patients ' life .",
  'Peroneal nerve palsy following knee dislocation is a serious problem , and neurolysis at the time of knee reconstruction does not always result in return of peroneal nerve function .',
  'Peripheral nerve injury ( PNI ) is a serious public health problem that is linked with motor , sensory and autonomic deficits .'],
 'neurolysis': ['The problem with calling it by this name is that it surrounds a true mixed peripheral nerve and not a radicule ( root ) .',
  'Common peroneal nerve ( CPN ) injury following a knee dislocation is a serious problem , and an optimal treatment is yet to be established .',
  'Peripheral nerve regeneration is a serious clinical problem .',
  'Neuromas are a debilitating peripheral nerve problem due to aberrant axon sprouting and inflammation after nerve injury .',
  'Peripheral nerve involvement has been described at alarming rates in some studies , which increases the chance of deformities , a serious problem , especially if one considers the age of these patients .',
  'Nerve injury , especially the large-size nerve damage , is a serious problem affecting millions of people .',
  'Perioperative peripheral neuropathy in abdominal free flap breast reconstruction is a preventable problem .',
  'Peripheral nerves are exposed to physical injuries usually caused by trauma that may lead to a significant loss of sensory or motor functions and is considered as a serious health problem for societies today .',
  'Poor muscle and nerve functional recovery after nerve damage is a serious clinical problem , particularly if there is prolonged delay before nerve-muscle contact is reestablished .',
  'Peripheral nerve injury is a serious clinical problem to be solved .',
  'Peripheral nerve injury ( PNI ) is a serious clinical health problem caused by the damage of peripheral nerves which results in neurological deficits and permanent disability .',
  'Peripheral nerve injury is a serious medical problem and severely affects normal life of patient .',
  'Peroneal nerve palsy after knee dislocation is a serious problem , and neurolysis at the time of knee reconstruction does not always result in return of peroneal nerve function .',
  'Knee dislocation with a common peroneal nerve injury is a serious problem .',
  "Peripheral nerve injury is a serious problem affecting significantly patients ' life .",
  'Peroneal nerve palsy following knee dislocation is a serious problem , and neurolysis at the time of knee reconstruction does not always result in return of peroneal nerve function .',
  'Peripheral nerve injury ( PNI ) is a serious public health problem that is linked with motor , sensory and autonomic deficits .'],
 'fviii': ['A major problem in treating hemophilia A patients with therapeutic factor VIII ( FVIII ) is that 20 % to 30 % of these patients produce neutralizing anti-FVIII antibodies .',
  'Reactivation : a severe problem in familial hemophagocytic lymphohistiocytosis .',
  'Inhibitor antibody formation in patients with haemophilia receiving factor VIII ( FVIII ) concentrate is a serious problem .',
  'The production of factor VIII ( FVIII ) inhibitors is a serious problem of replacement therapy with FVIII concentrates in hemophiliacs .',
  'Inhibitor formation in haemophilia patients receiving factor VIII ( FVIII ) concentrate is a serious problem requiring tolerance induction therapy .',
  'Factor VIII (FVIII)-neutralizing antibodies ( " inhibitors " ) are a serious problem in hemophilia A ( HA ) .',
  'Development of inhibitors is a severe complication of haemophilia posing many management challenges .',
  'The development of an inhibitor in a hemophiliac is a serious clinical problem .',
  "Development of neutralizing anti-factor (F)VIII antibodies ( ' inhibitors ' ) is a serious clinical problem in hemophilia A. Increased inhibitor risk has been associated with certain FVIII missense substitutions , including R593C in the A2 domain .",
  'The development of inhibitors to the infused factor in patients with haemophilia is a serious clinical problem .',
  'The production of factor VIII ( FVIII ) inhibitory antibodies is a serious problem in patients with hemophilia A. Immune tolerance induction ( ITI ) is the only strategy proven to eradicate persistent inhibitors and has been shown to be successful in 70 % of patients with hemophilia A. However , a minority of hemophilia patients present life-long inhibitors .',
  'Development of inhibitors to coagulation factors is a serious clinical problem in de-veloped countries and is more so in developing countries where treatment options are often limited .',
  'Although the antibodies cause a serious problem for affected individuals , they have been very useful in characterizing normal factor VIII and nonfunctional factor VIII-like protein that is found in the plasmas of 10 per cent of patients with mild hemophilia .',
  'The development of an inhibitor to transfused factor VIII ( FVIII ) is a serious treatment-related problem in haemophiliac children .',
  'Since development of inhibitory antibodies to FVIII is a serious problem in treatment of hemophilia A patients , we investigated the potential of this approach for inducing tolerance to FVIII in a hemophilia mouse model .',
  'In approximately 10 to 15 percent of congenital hemophilia A patients circulating antibodies to factor VIII appear in the blood that poses a serious problem in their treatment .'],
 'hemophilia': ['A major problem in treating hemophilia A patients with therapeutic factor VIII ( FVIII ) is that 20 % to 30 % of these patients produce neutralizing anti-FVIII antibodies .',
  'Reactivation : a severe problem in familial hemophagocytic lymphohistiocytosis .',
  'Inhibitor antibody formation in patients with haemophilia receiving factor VIII ( FVIII ) concentrate is a serious problem .',
  'The production of factor VIII ( FVIII ) inhibitors is a serious problem of replacement therapy with FVIII concentrates in hemophiliacs .',
  'Inhibitor formation in haemophilia patients receiving factor VIII ( FVIII ) concentrate is a serious problem requiring tolerance induction therapy .',
  'Factor VIII (FVIII)-neutralizing antibodies ( " inhibitors " ) are a serious problem in hemophilia A ( HA ) .',
  'Development of inhibitors is a severe complication of haemophilia posing many management challenges .',
  'The development of an inhibitor in a hemophiliac is a serious clinical problem .',
  "Development of neutralizing anti-factor (F)VIII antibodies ( ' inhibitors ' ) is a serious clinical problem in hemophilia A. Increased inhibitor risk has been associated with certain FVIII missense substitutions , including R593C in the A2 domain .",
  'The development of inhibitors to the infused factor in patients with haemophilia is a serious clinical problem .',
  'The production of factor VIII ( FVIII ) inhibitory antibodies is a serious problem in patients with hemophilia A. Immune tolerance induction ( ITI ) is the only strategy proven to eradicate persistent inhibitors and has been shown to be successful in 70 % of patients with hemophilia A. However , a minority of hemophilia patients present life-long inhibitors .',
  'Development of inhibitors to coagulation factors is a serious clinical problem in de-veloped countries and is more so in developing countries where treatment options are often limited .',
  'Although the antibodies cause a serious problem for affected individuals , they have been very useful in characterizing normal factor VIII and nonfunctional factor VIII-like protein that is found in the plasmas of 10 per cent of patients with mild hemophilia .',
  'The development of an inhibitor to transfused factor VIII ( FVIII ) is a serious treatment-related problem in haemophiliac children .',
  'Since development of inhibitory antibodies to FVIII is a serious problem in treatment of hemophilia A patients , we investigated the potential of this approach for inducing tolerance to FVIII in a hemophilia mouse model .',
  'In approximately 10 to 15 percent of congenital hemophilia A patients circulating antibodies to factor VIII appear in the blood that poses a serious problem in their treatment .'],
 'haemophilia': ['A major problem in treating hemophilia A patients with therapeutic factor VIII ( FVIII ) is that 20 % to 30 % of these patients produce neutralizing anti-FVIII antibodies .',
  'Reactivation : a severe problem in familial hemophagocytic lymphohistiocytosis .',
  'Inhibitor antibody formation in patients with haemophilia receiving factor VIII ( FVIII ) concentrate is a serious problem .',
  'The production of factor VIII ( FVIII ) inhibitors is a serious problem of replacement therapy with FVIII concentrates in hemophiliacs .',
  'Inhibitor formation in haemophilia patients receiving factor VIII ( FVIII ) concentrate is a serious problem requiring tolerance induction therapy .',
  'Factor VIII (FVIII)-neutralizing antibodies ( " inhibitors " ) are a serious problem in hemophilia A ( HA ) .',
  'Development of inhibitors is a severe complication of haemophilia posing many management challenges .',
  'The development of an inhibitor in a hemophiliac is a serious clinical problem .',
  "Development of neutralizing anti-factor (F)VIII antibodies ( ' inhibitors ' ) is a serious clinical problem in hemophilia A. Increased inhibitor risk has been associated with certain FVIII missense substitutions , including R593C in the A2 domain .",
  'The development of inhibitors to the infused factor in patients with haemophilia is a serious clinical problem .',
  'The production of factor VIII ( FVIII ) inhibitory antibodies is a serious problem in patients with hemophilia A. Immune tolerance induction ( ITI ) is the only strategy proven to eradicate persistent inhibitors and has been shown to be successful in 70 % of patients with hemophilia A. However , a minority of hemophilia patients present life-long inhibitors .',
  'Development of inhibitors to coagulation factors is a serious clinical problem in de-veloped countries and is more so in developing countries where treatment options are often limited .',
  'Although the antibodies cause a serious problem for affected individuals , they have been very useful in characterizing normal factor VIII and nonfunctional factor VIII-like protein that is found in the plasmas of 10 per cent of patients with mild hemophilia .',
  'The development of an inhibitor to transfused factor VIII ( FVIII ) is a serious treatment-related problem in haemophiliac children .',
  'Since development of inhibitory antibodies to FVIII is a serious problem in treatment of hemophilia A patients , we investigated the potential of this approach for inducing tolerance to FVIII in a hemophilia mouse model .',
  'In approximately 10 to 15 percent of congenital hemophilia A patients circulating antibodies to factor VIII appear in the blood that poses a serious problem in their treatment .'],
 'inhibitor': ['A major problem in treating hemophilia A patients with therapeutic factor VIII ( FVIII ) is that 20 % to 30 % of these patients produce neutralizing anti-FVIII antibodies .',
  'Reactivation : a severe problem in familial hemophagocytic lymphohistiocytosis .',
  'Inhibitor antibody formation in patients with haemophilia receiving factor VIII ( FVIII ) concentrate is a serious problem .',
  'The production of factor VIII ( FVIII ) inhibitors is a serious problem of replacement therapy with FVIII concentrates in hemophiliacs .',
  'Inhibitor formation in haemophilia patients receiving factor VIII ( FVIII ) concentrate is a serious problem requiring tolerance induction therapy .',
  'Factor VIII (FVIII)-neutralizing antibodies ( " inhibitors " ) are a serious problem in hemophilia A ( HA ) .',
  'Development of inhibitors is a severe complication of haemophilia posing many management challenges .',
  'The development of an inhibitor in a hemophiliac is a serious clinical problem .',
  "Development of neutralizing anti-factor (F)VIII antibodies ( ' inhibitors ' ) is a serious clinical problem in hemophilia A. Increased inhibitor risk has been associated with certain FVIII missense substitutions , including R593C in the A2 domain .",
  'The development of inhibitors to the infused factor in patients with haemophilia is a serious clinical problem .',
  'The production of factor VIII ( FVIII ) inhibitory antibodies is a serious problem in patients with hemophilia A. Immune tolerance induction ( ITI ) is the only strategy proven to eradicate persistent inhibitors and has been shown to be successful in 70 % of patients with hemophilia A. However , a minority of hemophilia patients present life-long inhibitors .',
  'Development of inhibitors to coagulation factors is a serious clinical problem in de-veloped countries and is more so in developing countries where treatment options are often limited .',
  'Although the antibodies cause a serious problem for affected individuals , they have been very useful in characterizing normal factor VIII and nonfunctional factor VIII-like protein that is found in the plasmas of 10 per cent of patients with mild hemophilia .',
  'The development of an inhibitor to transfused factor VIII ( FVIII ) is a serious treatment-related problem in haemophiliac children .',
  'Since development of inhibitory antibodies to FVIII is a serious problem in treatment of hemophilia A patients , we investigated the potential of this approach for inducing tolerance to FVIII in a hemophilia mouse model .',
  'In approximately 10 to 15 percent of congenital hemophilia A patients circulating antibodies to factor VIII appear in the blood that poses a serious problem in their treatment .'],
 'nematodes': ['However , the problem with ivermectin is that it is a monotherapy microfilaricide which has limited effect on the adult worm , and thus will need to be continued for the life span of the adult worm , which may last up to 15 years .',
  'These findings strongly suggest that AR , particularly in Haemonchus sp. , is a serious problem in these sheep flocks .',
  'Helminth infections represent a serious problem for the production of small ruminants that is currently aggravated by resistance to anthelmintic products and has induced a search for control alternatives , such as natural products .',
  'In veterinary practice , frequent treatment of closed populations has led to a serious problem of anthelminthic drug resistance which is now largely irreversible .',
  'Gastrointestinal nematodes ( GIN ) are a serious concern for sheep producers worldwide .',
  'Drug resistance in gastrointestinal nematodes is a severe problem for sheep farmers .',
  'Anthelmintic resistance ( AR ) is a serious problem for the control of equine gastrointestinal nematodes , particularly in the cyathostomins .',
  'Gastrointestinal nematodes ( GIN ) are a serious health problem and represent the most significant constraint in sheep grazing operations .',
  'Gastrointestinal nematodes are considered a serious economic problem affecting the livestock industry around the world .',
  'Anthelmintic resistance in nematode parasites of livestock is a serious problem worldwide .',
  'Multi-drug resistance in nematodes is a serious problem as lately several resistant phenotypes have emerged following the intermittent usage of synthetic nematicides .',
  'Anthelmintic resistance is a serious global problem because of the worldwide spread of resistant nematodes in animals and humans .',
  'Findings provided strong evidence that anthelmintic resistance is a serious problem on small ruminant farms throughout the southeastern United States .',
  'Unfortunately , IVM resistance is now a serious problem for parasite control in livestock and there is a concern about resistance development and spread in nematode parasites of humans .',
  'Anthelmintic resistance is a serious problem for the control of equine gastrointestinal nematodes .',
  'Anthelmintic resistance is a serious concern to the effective control of GIN parasites and has fuelled the focus to design and promote sustainable control of practices of parasite control .',
  'Although there has been extensive applied agricultural research ( research on plant-parasitic species has a long tradition ) , insufficient taxonomical knowledge , especially of free-living nematodes , is a serious problem concerning the use of nematodes in soil classification and assessment .',
  'Resistance to anthelmintics that are used to control parasite populations in domestic animals has become a serious problem worldwide .',
  'The infection of grazing ruminants with gastro-intestinal nematodes ( GINs ) is a severe problem in the Middle East .',
  'It is concluded that anthelmintic resistance to benzimidazoles and the probenzimidazole , febantel , is a serious and widespread problem in H. contortus in sheep in Malaysia .',
  'Recent studies on sheep and goat farms in the southern United States indicate that multiple-anthelmintic resistance in Haemonchus contortus is becoming a severe problem .',
  'It seems that BZresistance of H. contortus in Iran is not a serious problem as anticipated before .',
  'The results indicate that strongyles resistance to ivermectin in Poland is not a serious problem .',
  "Haemonchus contortus constitutes a severe problem for ruminant 's production , it is the most frequent nematode parasite both in template and tropical regions , induces economical losses , and shows increasing resistance to currently available anthelmintics .",
  'These data demonstrate a serious emerging problem in the United States of llama and alpaca GIN resistant to drugs from two of the three major anthelmintic classes .'],
 'anthelmintic': ['However , the problem with ivermectin is that it is a monotherapy microfilaricide which has limited effect on the adult worm , and thus will need to be continued for the life span of the adult worm , which may last up to 15 years .',
  'These findings strongly suggest that AR , particularly in Haemonchus sp. , is a serious problem in these sheep flocks .',
  'Helminth infections represent a serious problem for the production of small ruminants that is currently aggravated by resistance to anthelmintic products and has induced a search for control alternatives , such as natural products .',
  'In veterinary practice , frequent treatment of closed populations has led to a serious problem of anthelminthic drug resistance which is now largely irreversible .',
  'Gastrointestinal nematodes ( GIN ) are a serious concern for sheep producers worldwide .',
  'Drug resistance in gastrointestinal nematodes is a severe problem for sheep farmers .',
  'Anthelmintic resistance ( AR ) is a serious problem for the control of equine gastrointestinal nematodes , particularly in the cyathostomins .',
  'Gastrointestinal nematodes ( GIN ) are a serious health problem and represent the most significant constraint in sheep grazing operations .',
  'Gastrointestinal nematodes are considered a serious economic problem affecting the livestock industry around the world .',
  'Anthelmintic resistance in nematode parasites of livestock is a serious problem worldwide .',
  'Multi-drug resistance in nematodes is a serious problem as lately several resistant phenotypes have emerged following the intermittent usage of synthetic nematicides .',
  'Anthelmintic resistance is a serious global problem because of the worldwide spread of resistant nematodes in animals and humans .',
  'Findings provided strong evidence that anthelmintic resistance is a serious problem on small ruminant farms throughout the southeastern United States .',
  'Unfortunately , IVM resistance is now a serious problem for parasite control in livestock and there is a concern about resistance development and spread in nematode parasites of humans .',
  'Anthelmintic resistance is a serious problem for the control of equine gastrointestinal nematodes .',
  'Anthelmintic resistance is a serious concern to the effective control of GIN parasites and has fuelled the focus to design and promote sustainable control of practices of parasite control .',
  'Although there has been extensive applied agricultural research ( research on plant-parasitic species has a long tradition ) , insufficient taxonomical knowledge , especially of free-living nematodes , is a serious problem concerning the use of nematodes in soil classification and assessment .',
  'Resistance to anthelmintics that are used to control parasite populations in domestic animals has become a serious problem worldwide .',
  'The infection of grazing ruminants with gastro-intestinal nematodes ( GINs ) is a severe problem in the Middle East .',
  'It is concluded that anthelmintic resistance to benzimidazoles and the probenzimidazole , febantel , is a serious and widespread problem in H. contortus in sheep in Malaysia .',
  'Recent studies on sheep and goat farms in the southern United States indicate that multiple-anthelmintic resistance in Haemonchus contortus is becoming a severe problem .',
  'It seems that BZresistance of H. contortus in Iran is not a serious problem as anticipated before .',
  'The results indicate that strongyles resistance to ivermectin in Poland is not a serious problem .',
  "Haemonchus contortus constitutes a severe problem for ruminant 's production , it is the most frequent nematode parasite both in template and tropical regions , induces economical losses , and shows increasing resistance to currently available anthelmintics .",
  'These data demonstrate a serious emerging problem in the United States of llama and alpaca GIN resistant to drugs from two of the three major anthelmintic classes .'],
 'multidrug': ['A major problem with treating patients with cancer by traditional chemotherapeutic regimes is that their tumors often develop a multidrug resistant ( MDR ) phenotype and subsequently become insensitive to a range of different chemotoxic drugs .',
  'As a drawback of established drugs , like paclitaxel or the vinca alkaloids , the outcome of cancer chemotherapy is often affected by the emergence of the multidrug resistance phenotype .',
  'Multidrug resistance is a serious problem in current chemotherapy .',
  'Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases .',
  'The development of drug resistance and especially of multidrug resistance ( MDR ) is a serious problem during treatment of various malignant tumors .',
  'Multidrug resistance ( MDR ) is a severe problem in the treatment of cancer with overexpression of glycoprotein P ( Pgp , ABCB1 ) as a reason for chemotherapy failure .',
  'Multidrug resistance ( MDR ) is a serious problem faced in the treatment of malignant tumors .',
  'However , multidrug resistance ( MDR ) becomes a severe problem after long-term administration of chemotherapy drugs .',
  'The development of multidrug resistance ( MDR ) in breast cancer patients is a serious therapeutic problem .',
  'Multidrug resistance ( MDR ) to anticancer drugs is a serious health problem that in many cases leads to cancer treatment failure .',
  'Multidrug resistance ( MDR ) of hepatocellular carcinoma is a serious problem .',
  'Multidrug resistance ( MDR ) represents a serious problem in cancer treatment .',
  'Drug-drug interactions mediated by transporters are a serious clinical concern hence a tremendous amount of work has been done on the characterization of the transporter-mediated proteins in humans and animals .',
  'Multidrug resistance mediated by ATP binding cassette ( ABC ) transporters such as P-glycoprotein ( P-gp ) represents a serious problem for the development of effective anticancer drugs .',
  'Multidrug resistance ( MDR ) is a serious problem that hampers the success of cancer pharmacotherapy .',
  'This finding indicate that multidrug resistance does not represent a serious problem among NTS serotypes collected from the our medical center as monitored over a period of 7 years .',
  'Multidrug resistance ( MDR ) presents a serious problem in cancer chemotherapy .',
  'A DPD-deficient phenotype among cancer patients , which has posed a serious problem in 5FU-based chemotherapy , was reported to be in part ascribed to germline mutations in dihydropyrimidine dehydrogenase ( DPYD ) gene .',
  'Multidrug resistance of cancer cells constitutes a serious problem in chemotherapy and a challenging issue in the discovery of new cytotoxic drugs .',
  'The acquisition of multidrug resistance poses a serious problem in chemotherapy , and new types of transporters have been actively sought to overcome it .',
  'Multidrug resistance , mediated by the P-glycoprotein 170 transport pump , is a serious problem in multiple myeloma .',
  'The multi-drug resistance ( MDR ) of cancer cells , including 5-fluorouracil ( 5-FU ) resistance , has been a serious problem for patients with cancer .',
  'Multidrug resistance presents a serious problem in cancer chemotherapy .',
  'ATP-driven pumping of a variety of drugs out of cells by the human P-glycoprotein poses a serious problem to medical therapy .',
  'Drug resistance , in particular multidrug resistance , is a serious problem that impedes the effectiveness of chemotherapy .',
  'Multidrug resistance , especially multidrug efflux mechanisms that extrude structurally unrelated cytotoxic compounds from the cell by multidrug transporters , is a serious problem and one of the main reasons for the failure of therapeutic treatment of infections by pathogenic microorganisms as well as of cancer cells .',
  'Multidrug resistance is a serious problem in successful cancer chemotherapy .',
  'Multidrug resistance ( MDR ) is a serious medical problem and presents a major challenge to the treatment of disease and the development of novel therapeutics .',
  'Understanding fluconazole resistance is important as it emerged as a serious clinical problem for this CYP51 , sterol 14alpha-demethylase , inhibitor .',
  'The multidrug resistance ( MDR ) of malignant tumor is a troublesome problem in the chemotherapy .',
  'Multidrug resistance of cancer cells and pathogens is a serious clinical problem .',
  'Multidrug resistance of cancer cells is a serious problem in the treatment of tumors and is the leading cause of the frequent failure of chemotherapy .',
  'Multidrug resistance ( MDR ) is a serious problem in chemotherapy and is one of the main reasons for a poor outcome of gastric cancer .',
  'Multidrug resistance is a severe clinical problem in the chemotherapy of malignant disease .',
  'Multidrug resistance ( MDR ) presents a serious problem in cancer chemotherapy .'],
 'hens': ['The problem with this explanation is that , like mammalian hair , simple feathers could serve as insulation only when present in sufficiently high concentrations .',
  'Behaviors , such as aggression and certain fear-related behaviors , are a serious problem in the poultry industry that can lead to injury and cannibalism .',
  'Coccidiosis caused by Eimeria spp . is a common parasitic disease posing a serious problem in pigeon keeping .',
  'Over the last decades , mass mortalities of wild birds constitute a serious problem and may possibly have more causations such as natural toxins including cyanotoxins , parasitic diseases , industrial chemicals and other anthropogenic contaminants .',
  'This bird is considered an important vector of pathogens to man and domestic animals , and today it represents a serious hygienic-sanitary problem .',
  'The findings presented in this paper suggest that mycotic proventriculitis , presumably associated with M. ornithogaster , may be a serious but possibly opportunistic , although unusual , disease problem in gray partridges on game farms .',
  'Bone fragility in caged laying hens is a severe welfare problem , with fracture incidences in commercial flocks of up to 30 % of all hens during their life .',
  '1 . \u2003 Foot Pad Dermatitis ( FPD ) can be a serious health , quality and welfare problem in poultry production , with a significant affect on the economics of production .',
  'Death by chocolate : a fatal problem for an inquisitive wild parrot .',
  'ND is a serious problem in developing countries , causing huge loss in the poultry industry .',
  'The culling of male chicks is a serious problem , both in terms of animal welfare and waste disposal .',
  'Recently it has become a serious problem for layer especially when the birds start laying and also at the later stage of laying .',
  'Fractures of the keel bone , a bone extending ventrally from the sternum , are a serious health and welfare problem in free range laying hens .',
  'The disposal of by-products of duck production , including duck skin , is a serious concern as it results in environmental pollution .',
  'Severe feather pecking ( SFP ) is a serious problem in the egg production industry with regard to animal welfare and performance .',
  'Parasitical invasions constitute a serious veterinary-economic problem in pheasant breeding .',
  'Areca quid chewing is a serious problem in eastern Taiwan .',
  'Osteoporosis is a serious problem for the laying hen industry with economic , production , and welfare consequences .',
  'They confirm that in some circumstances laying from perches can be a serious problem , but that in other circumstances incidence can be reduced to a manageable frequency .',
  'Feather pecking is a serious problem in poultry housing , as it may lead to feather damage , injuries and even mortality .',
  'Tibiotarsal rotation in ostrich chicks is a serious problem that accounts for considerable financial loss to ostrich farmers .',
  'Feather pecking in laying hens is a serious behavioral problem and is often associated with feather eating .',
  'Poor nutrition is a serious problem in captive psittacine birds .',
  'Heat stress has become a serious problem in poultry industry along with rising of the global temperatures .',
  'On seven ( 23 % ) study farms , where less than 87 % of young chicks survived to 10 weeks without developing this condition , TTR was considered a serious problem .',
  'Land snails are an important calcium source for many passerines and human-induced changes in snail populations may pose a severe problem for breeding birds .',
  'Although NFM poses a serious problem , it remains a neglected pest of poultry in China and other Asian countries .',
  "Foot pad dermatitis ( FPD ) is a serious problem of the modern poultry industry , negatively affecting birds ' welfare and health status , walking and feeding activity , growth performance , carcass quality , and economic performance of meat production .",
  'The disposal of by-products of duck production , including duck skin , is a serious concern as it results in environmental pollution .',
  'However , pecking the feathers of conspecifics remains a serious problem that negatively affects the welfare of the birds as well as the economy of a farm .',
  'The poultry red mite ( Dermanyssus gallinae ) is a serious problem for the poultry industry worldwide .',
  'The blood feeding poultry red mite ( PRM ) , Dermanyssus gallinae , causes substantial economic damage to the egg laying industry worldwide , and is a serious welfare concern for laying hens and poultry house workers .',
  'Feather pecking is a serious economic and welfare problem in laying hens .',
  'Feather pecking in laying hens is a serious behavioral problem that is often associated with feather eating .',
  'Spotlight on avian pathology : red mite , a serious emergent problem in layer hens .',
  'Even though PRM poses a serious problem , very little is known about the basic biology of the mite .',
  'The husbandry of chicken for meat generates high levels of gases , being a serious problem for the health of birds and workers as well as for the environment .',
  'Long-term energy stress ( ES ) during the cold season is a serious problem for the breeding of yaks .',
  'Osteoporosis also makes bone breakage a serious problem during catching and transport of hens prior to slaughter .'],
 'poultry': ['The problem with this explanation is that , like mammalian hair , simple feathers could serve as insulation only when present in sufficiently high concentrations .',
  'Behaviors , such as aggression and certain fear-related behaviors , are a serious problem in the poultry industry that can lead to injury and cannibalism .',
  'Coccidiosis caused by Eimeria spp . is a common parasitic disease posing a serious problem in pigeon keeping .',
  'Over the last decades , mass mortalities of wild birds constitute a serious problem and may possibly have more causations such as natural toxins including cyanotoxins , parasitic diseases , industrial chemicals and other anthropogenic contaminants .',
  'This bird is considered an important vector of pathogens to man and domestic animals , and today it represents a serious hygienic-sanitary problem .',
  'The findings presented in this paper suggest that mycotic proventriculitis , presumably associated with M. ornithogaster , may be a serious but possibly opportunistic , although unusual , disease problem in gray partridges on game farms .',
  'Bone fragility in caged laying hens is a severe welfare problem , with fracture incidences in commercial flocks of up to 30 % of all hens during their life .',
  '1 . \u2003 Foot Pad Dermatitis ( FPD ) can be a serious health , quality and welfare problem in poultry production , with a significant affect on the economics of production .',
  'Death by chocolate : a fatal problem for an inquisitive wild parrot .',
  'ND is a serious problem in developing countries , causing huge loss in the poultry industry .',
  'The culling of male chicks is a serious problem , both in terms of animal welfare and waste disposal .',
  'Recently it has become a serious problem for layer especially when the birds start laying and also at the later stage of laying .',
  'Fractures of the keel bone , a bone extending ventrally from the sternum , are a serious health and welfare problem in free range laying hens .',
  'The disposal of by-products of duck production , including duck skin , is a serious concern as it results in environmental pollution .',
  'Severe feather pecking ( SFP ) is a serious problem in the egg production industry with regard to animal welfare and performance .',
  'Parasitical invasions constitute a serious veterinary-economic problem in pheasant breeding .',
  'Areca quid chewing is a serious problem in eastern Taiwan .',
  'Osteoporosis is a serious problem for the laying hen industry with economic , production , and welfare consequences .',
  'They confirm that in some circumstances laying from perches can be a serious problem , but that in other circumstances incidence can be reduced to a manageable frequency .',
  'Feather pecking is a serious problem in poultry housing , as it may lead to feather damage , injuries and even mortality .',
  'Tibiotarsal rotation in ostrich chicks is a serious problem that accounts for considerable financial loss to ostrich farmers .',
  'Feather pecking in laying hens is a serious behavioral problem and is often associated with feather eating .',
  'Poor nutrition is a serious problem in captive psittacine birds .',
  'Heat stress has become a serious problem in poultry industry along with rising of the global temperatures .',
  'On seven ( 23 % ) study farms , where less than 87 % of young chicks survived to 10 weeks without developing this condition , TTR was considered a serious problem .',
  'Land snails are an important calcium source for many passerines and human-induced changes in snail populations may pose a severe problem for breeding birds .',
  'Although NFM poses a serious problem , it remains a neglected pest of poultry in China and other Asian countries .',
  "Foot pad dermatitis ( FPD ) is a serious problem of the modern poultry industry , negatively affecting birds ' welfare and health status , walking and feeding activity , growth performance , carcass quality , and economic performance of meat production .",
  'The disposal of by-products of duck production , including duck skin , is a serious concern as it results in environmental pollution .',
  'However , pecking the feathers of conspecifics remains a serious problem that negatively affects the welfare of the birds as well as the economy of a farm .',
  'The poultry red mite ( Dermanyssus gallinae ) is a serious problem for the poultry industry worldwide .',
  'The blood feeding poultry red mite ( PRM ) , Dermanyssus gallinae , causes substantial economic damage to the egg laying industry worldwide , and is a serious welfare concern for laying hens and poultry house workers .',
  'Feather pecking is a serious economic and welfare problem in laying hens .',
  'Feather pecking in laying hens is a serious behavioral problem that is often associated with feather eating .',
  'Spotlight on avian pathology : red mite , a serious emergent problem in layer hens .',
  'Even though PRM poses a serious problem , very little is known about the basic biology of the mite .',
  'The husbandry of chicken for meat generates high levels of gases , being a serious problem for the health of birds and workers as well as for the environment .',
  'Long-term energy stress ( ES ) during the cold season is a serious problem for the breeding of yaks .',
  'Osteoporosis also makes bone breakage a serious problem during catching and transport of hens prior to slaughter .'],
 'birds': ['The problem with this explanation is that , like mammalian hair , simple feathers could serve as insulation only when present in sufficiently high concentrations .',
  'Behaviors , such as aggression and certain fear-related behaviors , are a serious problem in the poultry industry that can lead to injury and cannibalism .',
  'Coccidiosis caused by Eimeria spp . is a common parasitic disease posing a serious problem in pigeon keeping .',
  'Over the last decades , mass mortalities of wild birds constitute a serious problem and may possibly have more causations such as natural toxins including cyanotoxins , parasitic diseases , industrial chemicals and other anthropogenic contaminants .',
  'This bird is considered an important vector of pathogens to man and domestic animals , and today it represents a serious hygienic-sanitary problem .',
  'The findings presented in this paper suggest that mycotic proventriculitis , presumably associated with M. ornithogaster , may be a serious but possibly opportunistic , although unusual , disease problem in gray partridges on game farms .',
  'Bone fragility in caged laying hens is a severe welfare problem , with fracture incidences in commercial flocks of up to 30 % of all hens during their life .',
  '1 . \u2003 Foot Pad Dermatitis ( FPD ) can be a serious health , quality and welfare problem in poultry production , with a significant affect on the economics of production .',
  'Death by chocolate : a fatal problem for an inquisitive wild parrot .',
  'ND is a serious problem in developing countries , causing huge loss in the poultry industry .',
  'The culling of male chicks is a serious problem , both in terms of animal welfare and waste disposal .',
  'Recently it has become a serious problem for layer especially when the birds start laying and also at the later stage of laying .',
  'Fractures of the keel bone , a bone extending ventrally from the sternum , are a serious health and welfare problem in free range laying hens .',
  'The disposal of by-products of duck production , including duck skin , is a serious concern as it results in environmental pollution .',
  'Severe feather pecking ( SFP ) is a serious problem in the egg production industry with regard to animal welfare and performance .',
  'Parasitical invasions constitute a serious veterinary-economic problem in pheasant breeding .',
  'Areca quid chewing is a serious problem in eastern Taiwan .',
  'Osteoporosis is a serious problem for the laying hen industry with economic , production , and welfare consequences .',
  'They confirm that in some circumstances laying from perches can be a serious problem , but that in other circumstances incidence can be reduced to a manageable frequency .',
  'Feather pecking is a serious problem in poultry housing , as it may lead to feather damage , injuries and even mortality .',
  'Tibiotarsal rotation in ostrich chicks is a serious problem that accounts for considerable financial loss to ostrich farmers .',
  'Feather pecking in laying hens is a serious behavioral problem and is often associated with feather eating .',
  'Poor nutrition is a serious problem in captive psittacine birds .',
  'Heat stress has become a serious problem in poultry industry along with rising of the global temperatures .',
  'On seven ( 23 % ) study farms , where less than 87 % of young chicks survived to 10 weeks without developing this condition , TTR was considered a serious problem .',
  'Land snails are an important calcium source for many passerines and human-induced changes in snail populations may pose a severe problem for breeding birds .',
  'Although NFM poses a serious problem , it remains a neglected pest of poultry in China and other Asian countries .',
  "Foot pad dermatitis ( FPD ) is a serious problem of the modern poultry industry , negatively affecting birds ' welfare and health status , walking and feeding activity , growth performance , carcass quality , and economic performance of meat production .",
  'The disposal of by-products of duck production , including duck skin , is a serious concern as it results in environmental pollution .',
  'However , pecking the feathers of conspecifics remains a serious problem that negatively affects the welfare of the birds as well as the economy of a farm .',
  'The poultry red mite ( Dermanyssus gallinae ) is a serious problem for the poultry industry worldwide .',
  'The blood feeding poultry red mite ( PRM ) , Dermanyssus gallinae , causes substantial economic damage to the egg laying industry worldwide , and is a serious welfare concern for laying hens and poultry house workers .',
  'Feather pecking is a serious economic and welfare problem in laying hens .',
  'Feather pecking in laying hens is a serious behavioral problem that is often associated with feather eating .',
  'Spotlight on avian pathology : red mite , a serious emergent problem in layer hens .',
  'Even though PRM poses a serious problem , very little is known about the basic biology of the mite .',
  'The husbandry of chicken for meat generates high levels of gases , being a serious problem for the health of birds and workers as well as for the environment .',
  'Long-term energy stress ( ES ) during the cold season is a serious problem for the breeding of yaks .',
  'Osteoporosis also makes bone breakage a serious problem during catching and transport of hens prior to slaughter .'],
 'pecking': ['The problem with this explanation is that , like mammalian hair , simple feathers could serve as insulation only when present in sufficiently high concentrations .',
  'Behaviors , such as aggression and certain fear-related behaviors , are a serious problem in the poultry industry that can lead to injury and cannibalism .',
  'Coccidiosis caused by Eimeria spp . is a common parasitic disease posing a serious problem in pigeon keeping .',
  'Over the last decades , mass mortalities of wild birds constitute a serious problem and may possibly have more causations such as natural toxins including cyanotoxins , parasitic diseases , industrial chemicals and other anthropogenic contaminants .',
  'This bird is considered an important vector of pathogens to man and domestic animals , and today it represents a serious hygienic-sanitary problem .',
  'The findings presented in this paper suggest that mycotic proventriculitis , presumably associated with M. ornithogaster , may be a serious but possibly opportunistic , although unusual , disease problem in gray partridges on game farms .',
  'Bone fragility in caged laying hens is a severe welfare problem , with fracture incidences in commercial flocks of up to 30 % of all hens during their life .',
  '1 . \u2003 Foot Pad Dermatitis ( FPD ) can be a serious health , quality and welfare problem in poultry production , with a significant affect on the economics of production .',
  'Death by chocolate : a fatal problem for an inquisitive wild parrot .',
  'ND is a serious problem in developing countries , causing huge loss in the poultry industry .',
  'The culling of male chicks is a serious problem , both in terms of animal welfare and waste disposal .',
  'Recently it has become a serious problem for layer especially when the birds start laying and also at the later stage of laying .',
  'Fractures of the keel bone , a bone extending ventrally from the sternum , are a serious health and welfare problem in free range laying hens .',
  'The disposal of by-products of duck production , including duck skin , is a serious concern as it results in environmental pollution .',
  'Severe feather pecking ( SFP ) is a serious problem in the egg production industry with regard to animal welfare and performance .',
  'Parasitical invasions constitute a serious veterinary-economic problem in pheasant breeding .',
  'Areca quid chewing is a serious problem in eastern Taiwan .',
  'Osteoporosis is a serious problem for the laying hen industry with economic , production , and welfare consequences .',
  'They confirm that in some circumstances laying from perches can be a serious problem , but that in other circumstances incidence can be reduced to a manageable frequency .',
  'Feather pecking is a serious problem in poultry housing , as it may lead to feather damage , injuries and even mortality .',
  'Tibiotarsal rotation in ostrich chicks is a serious problem that accounts for considerable financial loss to ostrich farmers .',
  'Feather pecking in laying hens is a serious behavioral problem and is often associated with feather eating .',
  'Poor nutrition is a serious problem in captive psittacine birds .',
  'Heat stress has become a serious problem in poultry industry along with rising of the global temperatures .',
  'On seven ( 23 % ) study farms , where less than 87 % of young chicks survived to 10 weeks without developing this condition , TTR was considered a serious problem .',
  'Land snails are an important calcium source for many passerines and human-induced changes in snail populations may pose a severe problem for breeding birds .',
  'Although NFM poses a serious problem , it remains a neglected pest of poultry in China and other Asian countries .',
  "Foot pad dermatitis ( FPD ) is a serious problem of the modern poultry industry , negatively affecting birds ' welfare and health status , walking and feeding activity , growth performance , carcass quality , and economic performance of meat production .",
  'The disposal of by-products of duck production , including duck skin , is a serious concern as it results in environmental pollution .',
  'However , pecking the feathers of conspecifics remains a serious problem that negatively affects the welfare of the birds as well as the economy of a farm .',
  'The poultry red mite ( Dermanyssus gallinae ) is a serious problem for the poultry industry worldwide .',
  'The blood feeding poultry red mite ( PRM ) , Dermanyssus gallinae , causes substantial economic damage to the egg laying industry worldwide , and is a serious welfare concern for laying hens and poultry house workers .',
  'Feather pecking is a serious economic and welfare problem in laying hens .',
  'Feather pecking in laying hens is a serious behavioral problem that is often associated with feather eating .',
  'Spotlight on avian pathology : red mite , a serious emergent problem in layer hens .',
  'Even though PRM poses a serious problem , very little is known about the basic biology of the mite .',
  'The husbandry of chicken for meat generates high levels of gases , being a serious problem for the health of birds and workers as well as for the environment .',
  'Long-term energy stress ( ES ) during the cold season is a serious problem for the breeding of yaks .',
  'Osteoporosis also makes bone breakage a serious problem during catching and transport of hens prior to slaughter .'],
 'stent': ['Despite advances in the design of balloons and stents , restenosis remains a major drawback of coronary angioplasty .',
  'In this report we discuss the incidence of surgically induced distal target vessel stenosis in patients who undergo the minimally invasive coronary artery bypass grafting procedure , which represents a major drawback of the procedure in our experience .',
  'A high revascularization rate was the drawback of off-pump CABG for CHD patients in long-term follow-up .',
  'Coronary restenosis after stenting is still a major drawback of percutaneous coronary interventions ( PCI ) for 30 - 40 % of patients .',
  'Carotid angioplasty and stenting ( CAS ) is emerging as an alternative treatment for carotid stenosis , but neointimal hyperplasia ( NIH ) remains a drawback of this treatment strategy .',
  'A major drawback of this technique is the risk of side-branch ( SB ) closure after main vessel ( MV ) stenting .',
  'Restenosis after percutaneous transluminal coronary ( balloon ) angioplasty ( PTCA ) remains a major drawback of the procedure .',
  'Restenosis is a considerable drawback of stent-supported angioplasty of renal artery stenosis especially in small vessel diameters .',
  'Stent migration is a major drawback of currently used stents .',
  'Reoccurrence of restenosis following angioplasty of renal instent restenosis is a considerable drawback of stent-supported angioplasty of renal artery stenosis especially in small vessel diameters .',
  'The occurrence of in-stent restenosis is a major drawback of percutaneous transluminal coronary angioplasty with stent placement .',
  'In-stent restenosis ( ISR ) represents a major drawback of stented superficial femoral arteries ( SFAs ) .',
  'In the long term , a drawback of these stents is the occurrence of nontumoral occlusion at their proximal or distal parts .',
  'Ever since the first percutaneous transluminal angioplasty ( PTA ) was carried out in Switzerland in 1977 , restenosis remains a major drawback of this minimally invasive treatment intervention .',
  'Although the concept of coronary stenting significantly improved the interventional therapy of coronary artery disease , restenosis remains a major unsolved drawback of this technique .',
  'Coronary stents are playing an effective way of curing cardiovascular diseases while a major drawback of restenosis is in general still present .',
  'Although coronary artery bypass surgery has provided major advances in the treatment of coronary artery disease , narrowing of bypass vessels still constitutes a drawback of this therapy .',
  'Restenosis is a serious therapeutic problem after percutaneous transluminal angioplasty ( PTA ) .',
  'In-stent restenosis is a serious concern for patients treated through the stenting procedure , although this can be solved using drug-eluting stents and/or drug-eluting balloon catheters .',
  'With the possibility to implant long vessel segments using antiproliferative drugs to prevent restenosis , the practice of transforming the coronary vessels into stiff tubes with a full metal jacket covering all side branches and being unable to adjust to the long-term wall changes , including wall remodeling with lumen ectasia becomes a serious concern .',
  'The indication for interposition graft placement was recurrent stenosis with inability to perform endarterectomy in nine operations , a severe kink or technical problem during endarterectomy in nine , aneurysmal changes of the artery in six , and thrombosis of the endarterectomy site segment with stroke in two .',
  'In-stent restenosis still remains a serious clinical problem .',
  'Stent dislodgment remains a vexing problem in percutaneous coronary intervention .',
  'BACKGROUND : Slow flow or no reflow phenomenon is increasingly being recognized as a serious problem during coronary angioplasty and stenting .',
  'Stent thrombosis ( ST ) remains a catastrophic problem in patients undergoing percutaneous coronary intervention ( PCI ) .',
  'Despite improved pharmacological control of SAT in many patients , the potential for stent occlusion remains a life-threatening problem for those with more complex lesions .',
  'Slow or no reflow is a serious problem complicating catheter-based revascularization of degenerated saphenous vein bypass grafts .',
  'Intimal hyperplasia is a serious problem after percutaneous transluminal coronary angioplasty .',
  'Restenosis remains a vexing problem in patients undergoing percutaneous coronary interventions ( PCI ) .',
  'Despite significant advances in reducing the acute complications of percutaneous revascularization procedures with periprocedural medications and better techniques , chronic restenosis of dilated lesions remains a serious and frequent problem , occurring in 30 % to 50 % of cases .',
  'Late onset of type 1 endoleak with graft stents may cause severe lumen compression of the stent and aneurysm enlargement which might cause a serious problem especially in a patient whose graft stents left iliac branch is thrombosed and the left leg is supplied by the bypass graft from right CFA .',
  'Failure to deploy stents is a serious and relatively common problem that is associated with significant morbidity and mortality rates .',
  'In-stent restenosis remains a serious problem after the implantation of drug-eluting stents , which is attributable to neointima formation and re-endothelialization .',
  'Restenosis following percutaneous transluminal coronary angioplasty ( PTCA ) remains a serious problem in interventional cardiology .',
  'Restenosis after percutaneous coronary intervention remains a serious clinical problem .',
  'As the population with SFA stenting continues to increase , occurrence of ISR has become a serious problem .',
  'Restenosis after percutaneous coronary intervention remains to be a serious medical problem .',
  'Restenosis after percutaneous coronary intervention continues to be a serious problem in clinical cardiology .',
  'Restenosis after angioplasty is a serious clinical problem that can result in re-occlusion of the coronary artery .',
  'In-stent stenosis is a serious problem , occurring more frequently than earlier reports suggest and potentially resulting in late complications .',
  'Restenosis after coronary intervention has remained a vexing problem despite the introduction of nearly 24 newer coronary interventional devices .',
  'Refractory angina is a serious but relatively uncommon health problem , with a reported incidence of approximately 30 patients per million people/year .',
  'Intimal hyperplasia is a serious problem after percutaneous transluminal coronary angioplasty ( PTCA ) .',
  'Despite improved pharmacological control of SAT in many patients , the potential for stent occlusion remains a life-threatening problem for those with more complex lesions .',
  'Restenosis is a serious problem limiting the long-term efficacy of percutaneous transluminal coronary angioplasty .',
  'Slow/no-reflow phenomenon is a serious problem complicating primary percutaneous coronary intervention ( PCI ) for acute myocardial infarction ( AMI ) and is associated with a poor prognosis .',
  'Recurrent in-stent restenosis after balloon angioplasty poses a serious management problem .',
  'Chronic total coronary occlusions which make up 10 % to 20 % of all interventional procedures in high-volume centres remain a vexing problem for invasive cardiologists for 2 main reasons .',
  'Nevertheless , ISR remains a serious concern as late stent complications .',
  'Bare metal or drug-eluting stent implantation in last remaining vessel PCI ? A serious dilemma .',
  'However , abrupt closure after successful angioplasty remains a serious problem .',
  'Adverse events after thrombolysis were infrequent and , apart from cardiac arrest , not a serious problem when they occurred in the community : seven of 13 patients were resuscitated after cardiac arrest out of hospital .',
  'Late stent thrombosis ( LST ) which is a life threatening complication has emerged as a serious problem of drug-eluting stents ( DES ) .',
  'Although substantial progress in catheter and stent design has contributed to the success of percutaneous transluminal angioplasty ( PTA ) of atherosclerotic disease , the incidence of restenosis caused by in-stent neointimal hyperplasia remains a serious problem .',
  'Shedding light on in-stent restenosis : are bioresorbable vascular scaffolds the solution for a vexing problem ?',
  'In-stent restenosis after BMS implantation is a serious clinical problem .',
  'Although coronary angioplasty has become modern treatment of stable angina as well as of acute coronaries , acute occlusion of the vessel is still a serious problem .'],
 'coronary': ['Despite advances in the design of balloons and stents , restenosis remains a major drawback of coronary angioplasty .',
  'In this report we discuss the incidence of surgically induced distal target vessel stenosis in patients who undergo the minimally invasive coronary artery bypass grafting procedure , which represents a major drawback of the procedure in our experience .',
  'A high revascularization rate was the drawback of off-pump CABG for CHD patients in long-term follow-up .',
  'Coronary restenosis after stenting is still a major drawback of percutaneous coronary interventions ( PCI ) for 30 - 40 % of patients .',
  'Carotid angioplasty and stenting ( CAS ) is emerging as an alternative treatment for carotid stenosis , but neointimal hyperplasia ( NIH ) remains a drawback of this treatment strategy .',
  'A major drawback of this technique is the risk of side-branch ( SB ) closure after main vessel ( MV ) stenting .',
  'Restenosis after percutaneous transluminal coronary ( balloon ) angioplasty ( PTCA ) remains a major drawback of the procedure .',
  'Restenosis is a considerable drawback of stent-supported angioplasty of renal artery stenosis especially in small vessel diameters .',
  'Stent migration is a major drawback of currently used stents .',
  'Reoccurrence of restenosis following angioplasty of renal instent restenosis is a considerable drawback of stent-supported angioplasty of renal artery stenosis especially in small vessel diameters .',
  'The occurrence of in-stent restenosis is a major drawback of percutaneous transluminal coronary angioplasty with stent placement .',
  'In-stent restenosis ( ISR ) represents a major drawback of stented superficial femoral arteries ( SFAs ) .',
  'In the long term , a drawback of these stents is the occurrence of nontumoral occlusion at their proximal or distal parts .',
  'Ever since the first percutaneous transluminal angioplasty ( PTA ) was carried out in Switzerland in 1977 , restenosis remains a major drawback of this minimally invasive treatment intervention .',
  'Although the concept of coronary stenting significantly improved the interventional therapy of coronary artery disease , restenosis remains a major unsolved drawback of this technique .',
  'Coronary stents are playing an effective way of curing cardiovascular diseases while a major drawback of restenosis is in general still present .',
  'Although coronary artery bypass surgery has provided major advances in the treatment of coronary artery disease , narrowing of bypass vessels still constitutes a drawback of this therapy .',
  'Restenosis is a serious therapeutic problem after percutaneous transluminal angioplasty ( PTA ) .',
  'In-stent restenosis is a serious concern for patients treated through the stenting procedure , although this can be solved using drug-eluting stents and/or drug-eluting balloon catheters .',
  'With the possibility to implant long vessel segments using antiproliferative drugs to prevent restenosis , the practice of transforming the coronary vessels into stiff tubes with a full metal jacket covering all side branches and being unable to adjust to the long-term wall changes , including wall remodeling with lumen ectasia becomes a serious concern .',
  'The indication for interposition graft placement was recurrent stenosis with inability to perform endarterectomy in nine operations , a severe kink or technical problem during endarterectomy in nine , aneurysmal changes of the artery in six , and thrombosis of the endarterectomy site segment with stroke in two .',
  'In-stent restenosis still remains a serious clinical problem .',
  'Stent dislodgment remains a vexing problem in percutaneous coronary intervention .',
  'BACKGROUND : Slow flow or no reflow phenomenon is increasingly being recognized as a serious problem during coronary angioplasty and stenting .',
  'Stent thrombosis ( ST ) remains a catastrophic problem in patients undergoing percutaneous coronary intervention ( PCI ) .',
  'Despite improved pharmacological control of SAT in many patients , the potential for stent occlusion remains a life-threatening problem for those with more complex lesions .',
  'Slow or no reflow is a serious problem complicating catheter-based revascularization of degenerated saphenous vein bypass grafts .',
  'Intimal hyperplasia is a serious problem after percutaneous transluminal coronary angioplasty .',
  'Restenosis remains a vexing problem in patients undergoing percutaneous coronary interventions ( PCI ) .',
  'Despite significant advances in reducing the acute complications of percutaneous revascularization procedures with periprocedural medications and better techniques , chronic restenosis of dilated lesions remains a serious and frequent problem , occurring in 30 % to 50 % of cases .',
  'Late onset of type 1 endoleak with graft stents may cause severe lumen compression of the stent and aneurysm enlargement which might cause a serious problem especially in a patient whose graft stents left iliac branch is thrombosed and the left leg is supplied by the bypass graft from right CFA .',
  'Failure to deploy stents is a serious and relatively common problem that is associated with significant morbidity and mortality rates .',
  'In-stent restenosis remains a serious problem after the implantation of drug-eluting stents , which is attributable to neointima formation and re-endothelialization .',
  'Restenosis following percutaneous transluminal coronary angioplasty ( PTCA ) remains a serious problem in interventional cardiology .',
  'Restenosis after percutaneous coronary intervention remains a serious clinical problem .',
  'As the population with SFA stenting continues to increase , occurrence of ISR has become a serious problem .',
  'Restenosis after percutaneous coronary intervention remains to be a serious medical problem .',
  'Restenosis after percutaneous coronary intervention continues to be a serious problem in clinical cardiology .',
  'Restenosis after angioplasty is a serious clinical problem that can result in re-occlusion of the coronary artery .',
  'In-stent stenosis is a serious problem , occurring more frequently than earlier reports suggest and potentially resulting in late complications .',
  'Restenosis after coronary intervention has remained a vexing problem despite the introduction of nearly 24 newer coronary interventional devices .',
  'Refractory angina is a serious but relatively uncommon health problem , with a reported incidence of approximately 30 patients per million people/year .',
  'Intimal hyperplasia is a serious problem after percutaneous transluminal coronary angioplasty ( PTCA ) .',
  'Despite improved pharmacological control of SAT in many patients , the potential for stent occlusion remains a life-threatening problem for those with more complex lesions .',
  'Restenosis is a serious problem limiting the long-term efficacy of percutaneous transluminal coronary angioplasty .',
  'Slow/no-reflow phenomenon is a serious problem complicating primary percutaneous coronary intervention ( PCI ) for acute myocardial infarction ( AMI ) and is associated with a poor prognosis .',
  'Recurrent in-stent restenosis after balloon angioplasty poses a serious management problem .',
  'Chronic total coronary occlusions which make up 10 % to 20 % of all interventional procedures in high-volume centres remain a vexing problem for invasive cardiologists for 2 main reasons .',
  'Nevertheless , ISR remains a serious concern as late stent complications .',
  'Bare metal or drug-eluting stent implantation in last remaining vessel PCI ? A serious dilemma .',
  'However , abrupt closure after successful angioplasty remains a serious problem .',
  'Adverse events after thrombolysis were infrequent and , apart from cardiac arrest , not a serious problem when they occurred in the community : seven of 13 patients were resuscitated after cardiac arrest out of hospital .',
  'Late stent thrombosis ( LST ) which is a life threatening complication has emerged as a serious problem of drug-eluting stents ( DES ) .',
  'Although substantial progress in catheter and stent design has contributed to the success of percutaneous transluminal angioplasty ( PTA ) of atherosclerotic disease , the incidence of restenosis caused by in-stent neointimal hyperplasia remains a serious problem .',
  'Shedding light on in-stent restenosis : are bioresorbable vascular scaffolds the solution for a vexing problem ?',
  'In-stent restenosis after BMS implantation is a serious clinical problem .',
  'Although coronary angioplasty has become modern treatment of stable angina as well as of acute coronaries , acute occlusion of the vessel is still a serious problem .'],
 'angioplasty': ['Despite advances in the design of balloons and stents , restenosis remains a major drawback of coronary angioplasty .',
  'In this report we discuss the incidence of surgically induced distal target vessel stenosis in patients who undergo the minimally invasive coronary artery bypass grafting procedure , which represents a major drawback of the procedure in our experience .',
  'A high revascularization rate was the drawback of off-pump CABG for CHD patients in long-term follow-up .',
  'Coronary restenosis after stenting is still a major drawback of percutaneous coronary interventions ( PCI ) for 30 - 40 % of patients .',
  'Carotid angioplasty and stenting ( CAS ) is emerging as an alternative treatment for carotid stenosis , but neointimal hyperplasia ( NIH ) remains a drawback of this treatment strategy .',
  'A major drawback of this technique is the risk of side-branch ( SB ) closure after main vessel ( MV ) stenting .',
  'Restenosis after percutaneous transluminal coronary ( balloon ) angioplasty ( PTCA ) remains a major drawback of the procedure .',
  'Restenosis is a considerable drawback of stent-supported angioplasty of renal artery stenosis especially in small vessel diameters .',
  'Stent migration is a major drawback of currently used stents .',
  'Reoccurrence of restenosis following angioplasty of renal instent restenosis is a considerable drawback of stent-supported angioplasty of renal artery stenosis especially in small vessel diameters .',
  'The occurrence of in-stent restenosis is a major drawback of percutaneous transluminal coronary angioplasty with stent placement .',
  'In-stent restenosis ( ISR ) represents a major drawback of stented superficial femoral arteries ( SFAs ) .',
  'In the long term , a drawback of these stents is the occurrence of nontumoral occlusion at their proximal or distal parts .',
  'Ever since the first percutaneous transluminal angioplasty ( PTA ) was carried out in Switzerland in 1977 , restenosis remains a major drawback of this minimally invasive treatment intervention .',
  'Although the concept of coronary stenting significantly improved the interventional therapy of coronary artery disease , restenosis remains a major unsolved drawback of this technique .',
  'Coronary stents are playing an effective way of curing cardiovascular diseases while a major drawback of restenosis is in general still present .',
  'Although coronary artery bypass surgery has provided major advances in the treatment of coronary artery disease , narrowing of bypass vessels still constitutes a drawback of this therapy .',
  'Restenosis is a serious therapeutic problem after percutaneous transluminal angioplasty ( PTA ) .',
  'In-stent restenosis is a serious concern for patients treated through the stenting procedure , although this can be solved using drug-eluting stents and/or drug-eluting balloon catheters .',
  'With the possibility to implant long vessel segments using antiproliferative drugs to prevent restenosis , the practice of transforming the coronary vessels into stiff tubes with a full metal jacket covering all side branches and being unable to adjust to the long-term wall changes , including wall remodeling with lumen ectasia becomes a serious concern .',
  'The indication for interposition graft placement was recurrent stenosis with inability to perform endarterectomy in nine operations , a severe kink or technical problem during endarterectomy in nine , aneurysmal changes of the artery in six , and thrombosis of the endarterectomy site segment with stroke in two .',
  'In-stent restenosis still remains a serious clinical problem .',
  'Stent dislodgment remains a vexing problem in percutaneous coronary intervention .',
  'BACKGROUND : Slow flow or no reflow phenomenon is increasingly being recognized as a serious problem during coronary angioplasty and stenting .',
  'Stent thrombosis ( ST ) remains a catastrophic problem in patients undergoing percutaneous coronary intervention ( PCI ) .',
  'Despite improved pharmacological control of SAT in many patients , the potential for stent occlusion remains a life-threatening problem for those with more complex lesions .',
  'Slow or no reflow is a serious problem complicating catheter-based revascularization of degenerated saphenous vein bypass grafts .',
  'Intimal hyperplasia is a serious problem after percutaneous transluminal coronary angioplasty .',
  'Restenosis remains a vexing problem in patients undergoing percutaneous coronary interventions ( PCI ) .',
  'Despite significant advances in reducing the acute complications of percutaneous revascularization procedures with periprocedural medications and better techniques , chronic restenosis of dilated lesions remains a serious and frequent problem , occurring in 30 % to 50 % of cases .',
  'Late onset of type 1 endoleak with graft stents may cause severe lumen compression of the stent and aneurysm enlargement which might cause a serious problem especially in a patient whose graft stents left iliac branch is thrombosed and the left leg is supplied by the bypass graft from right CFA .',
  'Failure to deploy stents is a serious and relatively common problem that is associated with significant morbidity and mortality rates .',
  'In-stent restenosis remains a serious problem after the implantation of drug-eluting stents , which is attributable to neointima formation and re-endothelialization .',
  'Restenosis following percutaneous transluminal coronary angioplasty ( PTCA ) remains a serious problem in interventional cardiology .',
  'Restenosis after percutaneous coronary intervention remains a serious clinical problem .',
  'As the population with SFA stenting continues to increase , occurrence of ISR has become a serious problem .',
  'Restenosis after percutaneous coronary intervention remains to be a serious medical problem .',
  'Restenosis after percutaneous coronary intervention continues to be a serious problem in clinical cardiology .',
  'Restenosis after angioplasty is a serious clinical problem that can result in re-occlusion of the coronary artery .',
  'In-stent stenosis is a serious problem , occurring more frequently than earlier reports suggest and potentially resulting in late complications .',
  'Restenosis after coronary intervention has remained a vexing problem despite the introduction of nearly 24 newer coronary interventional devices .',
  'Refractory angina is a serious but relatively uncommon health problem , with a reported incidence of approximately 30 patients per million people/year .',
  'Intimal hyperplasia is a serious problem after percutaneous transluminal coronary angioplasty ( PTCA ) .',
  'Despite improved pharmacological control of SAT in many patients , the potential for stent occlusion remains a life-threatening problem for those with more complex lesions .',
  'Restenosis is a serious problem limiting the long-term efficacy of percutaneous transluminal coronary angioplasty .',
  'Slow/no-reflow phenomenon is a serious problem complicating primary percutaneous coronary intervention ( PCI ) for acute myocardial infarction ( AMI ) and is associated with a poor prognosis .',
  'Recurrent in-stent restenosis after balloon angioplasty poses a serious management problem .',
  'Chronic total coronary occlusions which make up 10 % to 20 % of all interventional procedures in high-volume centres remain a vexing problem for invasive cardiologists for 2 main reasons .',
  'Nevertheless , ISR remains a serious concern as late stent complications .',
  'Bare metal or drug-eluting stent implantation in last remaining vessel PCI ? A serious dilemma .',
  'However , abrupt closure after successful angioplasty remains a serious problem .',
  'Adverse events after thrombolysis were infrequent and , apart from cardiac arrest , not a serious problem when they occurred in the community : seven of 13 patients were resuscitated after cardiac arrest out of hospital .',
  'Late stent thrombosis ( LST ) which is a life threatening complication has emerged as a serious problem of drug-eluting stents ( DES ) .',
  'Although substantial progress in catheter and stent design has contributed to the success of percutaneous transluminal angioplasty ( PTA ) of atherosclerotic disease , the incidence of restenosis caused by in-stent neointimal hyperplasia remains a serious problem .',
  'Shedding light on in-stent restenosis : are bioresorbable vascular scaffolds the solution for a vexing problem ?',
  'In-stent restenosis after BMS implantation is a serious clinical problem .',
  'Although coronary angioplasty has become modern treatment of stable angina as well as of acute coronaries , acute occlusion of the vessel is still a serious problem .'],
 'stents': ['Despite advances in the design of balloons and stents , restenosis remains a major drawback of coronary angioplasty .',
  'In this report we discuss the incidence of surgically induced distal target vessel stenosis in patients who undergo the minimally invasive coronary artery bypass grafting procedure , which represents a major drawback of the procedure in our experience .',
  'A high revascularization rate was the drawback of off-pump CABG for CHD patients in long-term follow-up .',
  'Coronary restenosis after stenting is still a major drawback of percutaneous coronary interventions ( PCI ) for 30 - 40 % of patients .',
  'Carotid angioplasty and stenting ( CAS ) is emerging as an alternative treatment for carotid stenosis , but neointimal hyperplasia ( NIH ) remains a drawback of this treatment strategy .',
  'A major drawback of this technique is the risk of side-branch ( SB ) closure after main vessel ( MV ) stenting .',
  'Restenosis after percutaneous transluminal coronary ( balloon ) angioplasty ( PTCA ) remains a major drawback of the procedure .',
  'Restenosis is a considerable drawback of stent-supported angioplasty of renal artery stenosis especially in small vessel diameters .',
  'Stent migration is a major drawback of currently used stents .',
  'Reoccurrence of restenosis following angioplasty of renal instent restenosis is a considerable drawback of stent-supported angioplasty of renal artery stenosis especially in small vessel diameters .',
  'The occurrence of in-stent restenosis is a major drawback of percutaneous transluminal coronary angioplasty with stent placement .',
  'In-stent restenosis ( ISR ) represents a major drawback of stented superficial femoral arteries ( SFAs ) .',
  'In the long term , a drawback of these stents is the occurrence of nontumoral occlusion at their proximal or distal parts .',
  'Ever since the first percutaneous transluminal angioplasty ( PTA ) was carried out in Switzerland in 1977 , restenosis remains a major drawback of this minimally invasive treatment intervention .',
  'Although the concept of coronary stenting significantly improved the interventional therapy of coronary artery disease , restenosis remains a major unsolved drawback of this technique .',
  'Coronary stents are playing an effective way of curing cardiovascular diseases while a major drawback of restenosis is in general still present .',
  'Although coronary artery bypass surgery has provided major advances in the treatment of coronary artery disease , narrowing of bypass vessels still constitutes a drawback of this therapy .',
  'Restenosis is a serious therapeutic problem after percutaneous transluminal angioplasty ( PTA ) .',
  'In-stent restenosis is a serious concern for patients treated through the stenting procedure , although this can be solved using drug-eluting stents and/or drug-eluting balloon catheters .',
  'With the possibility to implant long vessel segments using antiproliferative drugs to prevent restenosis , the practice of transforming the coronary vessels into stiff tubes with a full metal jacket covering all side branches and being unable to adjust to the long-term wall changes , including wall remodeling with lumen ectasia becomes a serious concern .',
  'The indication for interposition graft placement was recurrent stenosis with inability to perform endarterectomy in nine operations , a severe kink or technical problem during endarterectomy in nine , aneurysmal changes of the artery in six , and thrombosis of the endarterectomy site segment with stroke in two .',
  'In-stent restenosis still remains a serious clinical problem .',
  'Stent dislodgment remains a vexing problem in percutaneous coronary intervention .',
  'BACKGROUND : Slow flow or no reflow phenomenon is increasingly being recognized as a serious problem during coronary angioplasty and stenting .',
  'Stent thrombosis ( ST ) remains a catastrophic problem in patients undergoing percutaneous coronary intervention ( PCI ) .',
  'Despite improved pharmacological control of SAT in many patients , the potential for stent occlusion remains a life-threatening problem for those with more complex lesions .',
  'Slow or no reflow is a serious problem complicating catheter-based revascularization of degenerated saphenous vein bypass grafts .',
  'Intimal hyperplasia is a serious problem after percutaneous transluminal coronary angioplasty .',
  'Restenosis remains a vexing problem in patients undergoing percutaneous coronary interventions ( PCI ) .',
  'Despite significant advances in reducing the acute complications of percutaneous revascularization procedures with periprocedural medications and better techniques , chronic restenosis of dilated lesions remains a serious and frequent problem , occurring in 30 % to 50 % of cases .',
  'Late onset of type 1 endoleak with graft stents may cause severe lumen compression of the stent and aneurysm enlargement which might cause a serious problem especially in a patient whose graft stents left iliac branch is thrombosed and the left leg is supplied by the bypass graft from right CFA .',
  'Failure to deploy stents is a serious and relatively common problem that is associated with significant morbidity and mortality rates .',
  'In-stent restenosis remains a serious problem after the implantation of drug-eluting stents , which is attributable to neointima formation and re-endothelialization .',
  'Restenosis following percutaneous transluminal coronary angioplasty ( PTCA ) remains a serious problem in interventional cardiology .',
  'Restenosis after percutaneous coronary intervention remains a serious clinical problem .',
  'As the population with SFA stenting continues to increase , occurrence of ISR has become a serious problem .',
  'Restenosis after percutaneous coronary intervention remains to be a serious medical problem .',
  'Restenosis after percutaneous coronary intervention continues to be a serious problem in clinical cardiology .',
  'Restenosis after angioplasty is a serious clinical problem that can result in re-occlusion of the coronary artery .',
  'In-stent stenosis is a serious problem , occurring more frequently than earlier reports suggest and potentially resulting in late complications .',
  'Restenosis after coronary intervention has remained a vexing problem despite the introduction of nearly 24 newer coronary interventional devices .',
  'Refractory angina is a serious but relatively uncommon health problem , with a reported incidence of approximately 30 patients per million people/year .',
  'Intimal hyperplasia is a serious problem after percutaneous transluminal coronary angioplasty ( PTCA ) .',
  'Despite improved pharmacological control of SAT in many patients , the potential for stent occlusion remains a life-threatening problem for those with more complex lesions .',
  'Restenosis is a serious problem limiting the long-term efficacy of percutaneous transluminal coronary angioplasty .',
  'Slow/no-reflow phenomenon is a serious problem complicating primary percutaneous coronary intervention ( PCI ) for acute myocardial infarction ( AMI ) and is associated with a poor prognosis .',
  'Recurrent in-stent restenosis after balloon angioplasty poses a serious management problem .',
  'Chronic total coronary occlusions which make up 10 % to 20 % of all interventional procedures in high-volume centres remain a vexing problem for invasive cardiologists for 2 main reasons .',
  'Nevertheless , ISR remains a serious concern as late stent complications .',
  'Bare metal or drug-eluting stent implantation in last remaining vessel PCI ? A serious dilemma .',
  'However , abrupt closure after successful angioplasty remains a serious problem .',
  'Adverse events after thrombolysis were infrequent and , apart from cardiac arrest , not a serious problem when they occurred in the community : seven of 13 patients were resuscitated after cardiac arrest out of hospital .',
  'Late stent thrombosis ( LST ) which is a life threatening complication has emerged as a serious problem of drug-eluting stents ( DES ) .',
  'Although substantial progress in catheter and stent design has contributed to the success of percutaneous transluminal angioplasty ( PTA ) of atherosclerotic disease , the incidence of restenosis caused by in-stent neointimal hyperplasia remains a serious problem .',
  'Shedding light on in-stent restenosis : are bioresorbable vascular scaffolds the solution for a vexing problem ?',
  'In-stent restenosis after BMS implantation is a serious clinical problem .',
  'Although coronary angioplasty has become modern treatment of stable angina as well as of acute coronaries , acute occlusion of the vessel is still a serious problem .'],
 'allograft': ['In conclusion , the ability of Tregs to promote the Th17/neutrophil-mediated pathway of rejection that we have described should be considered as a potential drawback of Treg-based cell therapy .',
  'Chemoprophylaxis with trimethoprim/sulphamethoxazole is recommended during the early post-transplantation period , but the optimal duration has not been determined and a main drawback of chemoprophylaxis is the development of resistance of the commensal faecal flora .',
  'One child died of a secondary acute rejection resistant to treatment 7 years after the transplantation , 1 has a severe coronary problem 13 years after the transplantation , and three children ( including the diseased child ) have psychomotor development abnormalities .',
  'De-novo malignancies continue to be a serious problem after kidney transplantation .',
  'Despite significant advances in organ preservation , surgical techniques and perioperative care , primary graft dysfunction is a serious medical problem in transplantation medicine in general and a specific problem in patients undergoing lung transplantation .',
  'The detectable rejection process shows that the posterior part of the eye is not absolutely immunologically privileged and that rejection is a serious problem in human retinal transplantation .',
  'Graft rejection is a serious problem despite immunosuppressive agents .',
  'Antibody-mediated graft rejection caused by donor-specific antibodies ( DSA-MR ) remains a serious problem after heart transplantation ( HTx ) .',
  'De novo malignancies following renal transplantation represent a serious problem endangering the prognosis of otherwise successfully transplanted patients .',
  'Tricuspid regurgitation following heart transplantation can become a severe problem in a subset of patients , where medical therapy fails .',
  'Among the various complications of heart transplantation ( HTx ) , the vasculopathy of the allograft ( CAV ) , a phenomenon of chronic rejection , is still a serious problem .',
  'Delayed xenograft rejection remains a serious problem .',
  'Chronic graft rejection mediated by cellular immune responses still poses a serious clinical problem in transplant surgery .',
  'Although 85,000 heart transplantations have been performed worldwide , coronary allograft vasculopathy ( CAV ) , which is a phenomenon of chronic rejection , is still a serious problem .',
  'While our experience is of a far lower incidence of rejection than registry data , rejection remains a serious problem after paediatric heart transplantation .',
  'Despite the availability of potent immunosuppressive drugs , rejection after organ transplantation in children remains a serious concern , and may lead to significant morbidity , graft loss , and death of the patient .',
  'Hemodynamically significant acute graft rejection in pediatric heart transplant recipients is a devastating problem with poor short- and long-term outcomes .',
  'Noncompliance with immunosuppressant therapy is a serious problem that leads to the possibility of graft rejection , even in the long term after liver transplantation .',
  'End-stage allograft failure following cardiac transplantation is a devastating problem , and retransplantation offers the only chance for survival .',
  'Graft coronary artery disease , a serious problem after orthotopic heart transplantation ( OHT ) , has multifactorial etiologies with dyslipidemia as one of the major risk factors .',
  'However , acute and chronic rejection still remains a vexing problem for the long term function of the transplanted organ .',
  'Citrulline levels < 13 micromoles/L should alert the clinical team that a serious problem ( rejection or infection ) could be looming in a previously stable intestinal recipient .',
  'Severe cardiac allograft rejection remains a serious problem despite the advances of cyclosporine-based immunosuppression .',
  'In clinical heart-lung transplantation , reperfusion injury is a serious problem .',
  'Inflammatory processes in chronic rejection remain a serious clinical problem in organ transplantation .',
  'Morbidity caused by early allograft dysfunction , manifested by a progressive increase in pulmonary vascular resistance and a decrease in oxygenation , remains a serious problem in lung transplantation .',
  'TCAD is a serious problem in transplant recipients and may affect patients of any age , even neonates .',
  'Despite unequivocal success , relapse after transplant remains a serious problem , being the main cause of treatment failure .',
  'The lack of an absolute correlation between DSA , crossmatching and outcome presents a serious dilemma for the transplant community .',
  'Polyoma is a serious concern for SPK transplant recipients .',
  'However , the development of malignancies after transplantation is a serious problem .',
  'To date , however , no study has provided any psychosocial follow-up of donors who developed a serious health problem such as end-stage renal disease ( ESRD ) .',
  'It is concluded that the development of obstructive airway disease represents a serious problem in all types of lung transplantation .',
  'Allograft rejection is a serious concern in heart transplant medicine .',
  'We believe that immunosuppression-induced pneumonitis in a lung allograft is a serious dilemma for lung transplant physicians',
  'However , graft rejection is a severe problem with clinical small bowel transplantation , because small intestinal wall contains large amounts of lymphoid tissue .',
  'Primary graft dysfunction remains a serious problem after heart transplant .',
  'With new immunosuppressive agents the incidence of acute rejection has been significantly reduced , but infection has become a serious problem .',
  'Graft rejection remains a serious problem in patients transplanted for severe aplastic anemia .',
  'In lung transplantation , reimplantation response is still a serious problem .',
  'Although 100,000 cardiac transplants have been performed , coronary allograft vasculopathy ( CAV ) , which is a phenomenon of chronic rejection , is still a serious problem .',
  'Malignant tumors represent a serious problem in transplantation medicine .',
  'Allograft rejection continues to be a vexing problem in clinical lung transplantation , and the role played by passenger leukocytes in the rejection or acceptance of an organ is unclear .',
  'In organ allotransplantation represents a serious problem acute rejection , which is the reaction of recipient organism aimed to reject the transplanted organ .'],
 'phage': ['In earlier studies the inability of phages to kill intracellular bacteria has been thought to be a major drawback of phage therapy .',
  'A drawback of the common phagemid/helper phage systems is the high infective background of phages that do not display the protein of interest , but are propagated due to non-specific binding to selection targets .',
  'A major drawback of phage therapy is that bacteriophages have high specificity and can not infect all the sub-strains of a particular pathogenic strain .',
  'However , a major drawback of phage display technology is that because the degree of the enrichment can not be controlled during the bio-panning process , it frequently results in a limited number of clones .',
  'A major drawback of filamentous phage is its size .',
  'A drawback of the approach is the absence of PTMs in phage-displayed peptides .',
  'T4 phage is also important in phage therapy , which represents an alternative treatment of bacterial infections since the bacterial resistance to antibiotics has become a serious medical problem .',
  'Today , multi-drug resistant bacteria are a serious health problem , and phage therapy enjoys renewed interest .',
  'Most phage-resistant Y. pestis mutants become attenuated and thus should not pose a serious problem for bacteriophage therapy of plague .',
  'Along with increasing worldwide fruit and vegetable consumption , plant diseases and human foodborne illnesses are becoming a serious economic problem , resulting in a focus on optimization of phage treatment .',
  'Antibiotic-resistant bacteria have emerged as a serious problem ; bacteriophages have , therefore , been proposed as a therapeutic alternative to antibiotics .',
  'The high load of coliforms of treated wastewater effluents that are discharged into the rivers or agricultural lands is a serious concern of the Iran Department of Environment and the reduction of coliforms using phages to overcome this problem is an asset .',
  'Bacterial resistance to antibiotics , a serious problem in contemporary medicine , does not implicate resistance to phage lysis mechanisms .',
  'Bacteriophages are recognized as a serious problem in industrial fermentations ; however , YS61 differed from many virulent phages associated with food fermentations since it was difficult to propagate and was very susceptible to resistance development .'],
 'phages': ['In earlier studies the inability of phages to kill intracellular bacteria has been thought to be a major drawback of phage therapy .',
  'A drawback of the common phagemid/helper phage systems is the high infective background of phages that do not display the protein of interest , but are propagated due to non-specific binding to selection targets .',
  'A major drawback of phage therapy is that bacteriophages have high specificity and can not infect all the sub-strains of a particular pathogenic strain .',
  'However , a major drawback of phage display technology is that because the degree of the enrichment can not be controlled during the bio-panning process , it frequently results in a limited number of clones .',
  'A major drawback of filamentous phage is its size .',
  'A drawback of the approach is the absence of PTMs in phage-displayed peptides .',
  'T4 phage is also important in phage therapy , which represents an alternative treatment of bacterial infections since the bacterial resistance to antibiotics has become a serious medical problem .',
  'Today , multi-drug resistant bacteria are a serious health problem , and phage therapy enjoys renewed interest .',
  'Most phage-resistant Y. pestis mutants become attenuated and thus should not pose a serious problem for bacteriophage therapy of plague .',
  'Along with increasing worldwide fruit and vegetable consumption , plant diseases and human foodborne illnesses are becoming a serious economic problem , resulting in a focus on optimization of phage treatment .',
  'Antibiotic-resistant bacteria have emerged as a serious problem ; bacteriophages have , therefore , been proposed as a therapeutic alternative to antibiotics .',
  'The high load of coliforms of treated wastewater effluents that are discharged into the rivers or agricultural lands is a serious concern of the Iran Department of Environment and the reduction of coliforms using phages to overcome this problem is an asset .',
  'Bacterial resistance to antibiotics , a serious problem in contemporary medicine , does not implicate resistance to phage lysis mechanisms .',
  'Bacteriophages are recognized as a serious problem in industrial fermentations ; however , YS61 differed from many virulent phages associated with food fermentations since it was difficult to propagate and was very susceptible to resistance development .'],
 'bacteriophages': ['In earlier studies the inability of phages to kill intracellular bacteria has been thought to be a major drawback of phage therapy .',
  'A drawback of the common phagemid/helper phage systems is the high infective background of phages that do not display the protein of interest , but are propagated due to non-specific binding to selection targets .',
  'A major drawback of phage therapy is that bacteriophages have high specificity and can not infect all the sub-strains of a particular pathogenic strain .',
  'However , a major drawback of phage display technology is that because the degree of the enrichment can not be controlled during the bio-panning process , it frequently results in a limited number of clones .',
  'A major drawback of filamentous phage is its size .',
  'A drawback of the approach is the absence of PTMs in phage-displayed peptides .',
  'T4 phage is also important in phage therapy , which represents an alternative treatment of bacterial infections since the bacterial resistance to antibiotics has become a serious medical problem .',
  'Today , multi-drug resistant bacteria are a serious health problem , and phage therapy enjoys renewed interest .',
  'Most phage-resistant Y. pestis mutants become attenuated and thus should not pose a serious problem for bacteriophage therapy of plague .',
  'Along with increasing worldwide fruit and vegetable consumption , plant diseases and human foodborne illnesses are becoming a serious economic problem , resulting in a focus on optimization of phage treatment .',
  'Antibiotic-resistant bacteria have emerged as a serious problem ; bacteriophages have , therefore , been proposed as a therapeutic alternative to antibiotics .',
  'The high load of coliforms of treated wastewater effluents that are discharged into the rivers or agricultural lands is a serious concern of the Iran Department of Environment and the reduction of coliforms using phages to overcome this problem is an asset .',
  'Bacterial resistance to antibiotics , a serious problem in contemporary medicine , does not implicate resistance to phage lysis mechanisms .',
  'Bacteriophages are recognized as a serious problem in industrial fermentations ; however , YS61 differed from many virulent phages associated with food fermentations since it was difficult to propagate and was very susceptible to resistance development .'],
 'coliforms': ['In earlier studies the inability of phages to kill intracellular bacteria has been thought to be a major drawback of phage therapy .',
  'A drawback of the common phagemid/helper phage systems is the high infective background of phages that do not display the protein of interest , but are propagated due to non-specific binding to selection targets .',
  'A major drawback of phage therapy is that bacteriophages have high specificity and can not infect all the sub-strains of a particular pathogenic strain .',
  'However , a major drawback of phage display technology is that because the degree of the enrichment can not be controlled during the bio-panning process , it frequently results in a limited number of clones .',
  'A major drawback of filamentous phage is its size .',
  'A drawback of the approach is the absence of PTMs in phage-displayed peptides .',
  'T4 phage is also important in phage therapy , which represents an alternative treatment of bacterial infections since the bacterial resistance to antibiotics has become a serious medical problem .',
  'Today , multi-drug resistant bacteria are a serious health problem , and phage therapy enjoys renewed interest .',
  'Most phage-resistant Y. pestis mutants become attenuated and thus should not pose a serious problem for bacteriophage therapy of plague .',
  'Along with increasing worldwide fruit and vegetable consumption , plant diseases and human foodborne illnesses are becoming a serious economic problem , resulting in a focus on optimization of phage treatment .',
  'Antibiotic-resistant bacteria have emerged as a serious problem ; bacteriophages have , therefore , been proposed as a therapeutic alternative to antibiotics .',
  'The high load of coliforms of treated wastewater effluents that are discharged into the rivers or agricultural lands is a serious concern of the Iran Department of Environment and the reduction of coliforms using phages to overcome this problem is an asset .',
  'Bacterial resistance to antibiotics , a serious problem in contemporary medicine , does not implicate resistance to phage lysis mechanisms .',
  'Bacteriophages are recognized as a serious problem in industrial fermentations ; however , YS61 differed from many virulent phages associated with food fermentations since it was difficult to propagate and was very susceptible to resistance development .'],
 'cerebral': ['A drawback of pre-existing in vitro models is that since susceptibility to ischemic injury is age-dependent ; neuroprotection is being studied in neurons that have intrinsic resistance to oxygen-glucose deprivation ( OGD ) .',
  'Limited coverage of the brain in the z-axis has been a drawback of perfusion CT .',
  'Reperfusion injury is a serious problem in ischemic stroke therapy , which leads to neuronal damage and intracranial hemorrhage ( ICH ) .',
  'Unfortunately , the cerebral re-perfusion syndrome is still a serious and not completely solved problem .',
  'Because it is a severe and complex problem , several studies have been done aiming to elucidate the mechanisms of the ischemic phenomenon and aiming to abolish or to diminish its effects , using drugs that protect the neurons from ischaemia-induced damage .',
  'Cell therapy is a potential therapeutic method for cerebral ischemia , which remains a serious problem .',
  'Cerebral ischemia/reperfusion injury is a severe problem in patients with brain ischemia .',
  'BACKGROUND Cerebral ischemia-reperfusion injury ( CIRI ) remains a serious health problem .',
  "Vascular insufficiency of the child 's brain is a serious problem because perfusion can be disturbed sufficiently enough to cause permanent brain changes with extensive neurological deficit resulting in some .",
  'Cerebral ischemia-reperfusion ( IR ) has attracted wide attention as a serious clinical problem .',
  "Cerebral ischemia-reperfusion ( I/R ) injury is also a serious problem for patients ' outcomes .",
  'In particularly , hippocampal injury after ischemia-reperfusion is a serious problem as it contributes to vascular dementia .',
  'Ischemia is a serious problem in clinical medicine , and effective methods are needed to detect ischemia before the injury becomes irreversible .',
  'Unfortunately , cerebral re-perfusion syndrome is a serious unresolved problem .',
  'Inflammatory response that occur post-ischemia is a serious problem in the treatment of ischemic brain disease .'],
 'perfusion': ['A drawback of pre-existing in vitro models is that since susceptibility to ischemic injury is age-dependent ; neuroprotection is being studied in neurons that have intrinsic resistance to oxygen-glucose deprivation ( OGD ) .',
  'Limited coverage of the brain in the z-axis has been a drawback of perfusion CT .',
  'Reperfusion injury is a serious problem in ischemic stroke therapy , which leads to neuronal damage and intracranial hemorrhage ( ICH ) .',
  'Unfortunately , the cerebral re-perfusion syndrome is still a serious and not completely solved problem .',
  'Because it is a severe and complex problem , several studies have been done aiming to elucidate the mechanisms of the ischemic phenomenon and aiming to abolish or to diminish its effects , using drugs that protect the neurons from ischaemia-induced damage .',
  'Cell therapy is a potential therapeutic method for cerebral ischemia , which remains a serious problem .',
  'Cerebral ischemia/reperfusion injury is a severe problem in patients with brain ischemia .',
  'BACKGROUND Cerebral ischemia-reperfusion injury ( CIRI ) remains a serious health problem .',
  "Vascular insufficiency of the child 's brain is a serious problem because perfusion can be disturbed sufficiently enough to cause permanent brain changes with extensive neurological deficit resulting in some .",
  'Cerebral ischemia-reperfusion ( IR ) has attracted wide attention as a serious clinical problem .',
  "Cerebral ischemia-reperfusion ( I/R ) injury is also a serious problem for patients ' outcomes .",
  'In particularly , hippocampal injury after ischemia-reperfusion is a serious problem as it contributes to vascular dementia .',
  'Ischemia is a serious problem in clinical medicine , and effective methods are needed to detect ischemia before the injury becomes irreversible .',
  'Unfortunately , cerebral re-perfusion syndrome is a serious unresolved problem .',
  'Inflammatory response that occur post-ischemia is a serious problem in the treatment of ischemic brain disease .'],
 'neurons': ['A drawback of pre-existing in vitro models is that since susceptibility to ischemic injury is age-dependent ; neuroprotection is being studied in neurons that have intrinsic resistance to oxygen-glucose deprivation ( OGD ) .',
  'Limited coverage of the brain in the z-axis has been a drawback of perfusion CT .',
  'Reperfusion injury is a serious problem in ischemic stroke therapy , which leads to neuronal damage and intracranial hemorrhage ( ICH ) .',
  'Unfortunately , the cerebral re-perfusion syndrome is still a serious and not completely solved problem .',
  'Because it is a severe and complex problem , several studies have been done aiming to elucidate the mechanisms of the ischemic phenomenon and aiming to abolish or to diminish its effects , using drugs that protect the neurons from ischaemia-induced damage .',
  'Cell therapy is a potential therapeutic method for cerebral ischemia , which remains a serious problem .',
  'Cerebral ischemia/reperfusion injury is a severe problem in patients with brain ischemia .',
  'BACKGROUND Cerebral ischemia-reperfusion injury ( CIRI ) remains a serious health problem .',
  "Vascular insufficiency of the child 's brain is a serious problem because perfusion can be disturbed sufficiently enough to cause permanent brain changes with extensive neurological deficit resulting in some .",
  'Cerebral ischemia-reperfusion ( IR ) has attracted wide attention as a serious clinical problem .',
  "Cerebral ischemia-reperfusion ( I/R ) injury is also a serious problem for patients ' outcomes .",
  'In particularly , hippocampal injury after ischemia-reperfusion is a serious problem as it contributes to vascular dementia .',
  'Ischemia is a serious problem in clinical medicine , and effective methods are needed to detect ischemia before the injury becomes irreversible .',
  'Unfortunately , cerebral re-perfusion syndrome is a serious unresolved problem .',
  'Inflammatory response that occur post-ischemia is a serious problem in the treatment of ischemic brain disease .'],
 'urine': ["A drawback of free supply may be that , as in 24 % of the present series , women primarily use the pads as a solution to the problem of incontinence , without a doctor 's intervention and before a trial of continence-promoting or curative measures .",
  'Desmopressin plays a major role in the treatment of monosymptomatic enuresis but has the drawback of a high relapse rate after medical treatment .',
  'Stress urinary incontinence ( SUI ) , defined as the involuntary loss of considerable amounts of urine during increased abdominal pressure ( exertion , effort , sneezing , coughing , etc . ) , is a severe problem to the individuals affected and a significant medical , social and economic challenge .',
  'Nocturnal enuresis is a serious health problem affecting a significant portion of the population .',
  'Urinary incontinence , although not life threatening , can be a distressing problem with a profound impact on quality of life .',
  'Nocturia -- waking up during the night due to the urge to urinate and empty the bladder -- is a serious problem for affected patients .',
  "It was seen that urinary incontinence is a serious health problem in the postpartum period , that it disrupts a woman 's daily activities , affects her sex life but that despite this , women do not receive needed medical assistance .",
  'Incontinence can be a devastating problem to many individuals .',
  'Urinary incontinence is a debilitating problem that requires careful evaluation .',
  'The students who had experienced urinary loss rated the problem with a 2.3 average score ( ranging form 0 to 6 ) , with 0 being no problem and 10 being a serious problem .',
  'Nocturnal enuresis after the fifth year of life is a distressing problem .',
  'Accidental urine leakage is a distressing problem that affects around one in three women .',
  'Preview Involuntary loss of urine is a troublesome , embarrassing problem among women .',
  'Overactive bladder ( OAB ) is a distressing problem that affects many women in the UK .',
  'Urinary incontinence is a debilitating problem that affects over 20 million people in the United States .',
  'Recurrent stress urinary incontinence is a distressing problem .',
  'However , only 24 % of the stress incontinent and 28 % of the urge incontinent patients found their incontinence to be " quite a problem " or " a serious problem . " Patients leaking urine only " occasionally , " " once a week , " leaking " drops , " and finding the leakage to be " a bit of a problem " had median leakage 0 g during ST and 24hPT .',
  'Sixty-five percent of patients using pads considered urinary leakage to be a problem , but only 1 considered it a serious problem .',
  'Urge urinary incontinence is a debilitating chronic condition that poses challenges for affected women and the clinicians who care for them .',
  'Urinary incontinence is a serious problem for many women .',
  'Urinary retention is a serious urological problem associated with spinal cord injuries ( SCIs ) and other pelvic disorders .',
  'Urinary incontinence ( UI ) is a distressing problem for older people .',
  'Urinary incontinence is a severe and common health problem .',
  'Urination impairments in children with neurological disorders are a serious clinical problem .',
  'Urinary incontinence results in substantial morbidity within society and presents a serious public health problem .',
  'Women were more often incontinent than men and experienced it as a serious problem , and more women than men had changed their dietary habits .',
  'Urinary incontinence ( UI ) or involuntary leakage of urine is a distressing and serious health problem .',
  'Urinary incontinence is a serious and costly problem that affects many patients , especially the elderly .',
  'For a limited group of people , urinary incontinence is a severe problem .',
  'Stress urinary incontinence ( SUI ) is a serious problem in women who have delivered vaginally , and causes some sexual dysfunction .',
  'Urinary incontinence in children is a distressing problem that often is magnified during puberty , since the children then realize the full significance of the disorder .',
  'Incontinence is a distressing , complex health problem which disproportionately affects older people .',
  'Bladder hyperactivity is a debilitating problem that affects many individuals .'],
 'mycoplasma': ['Cell line contamination is a major drawback of main cell banks of the world and it has cost of losing important biological products or valuable research .',
  'A drawback of the agroinfiltration technique is its temperature dependence : early studies have shown that temperatures above 29 \u2009 ° C are nonpermissive to tumour induction by the bacterium as a result of failure in pilus formation .',
  'This presents a serious concern regarding the risk of mycoplasma contamination for research laboratories and commercial facilities developing and manufacturing cell-derived biological and biopharmaceutical products for therapeutic use .',
  'Mycoplasma gallisepticum ( MG ) has repeatedly emerged as a serious problem in U.S. broiler , layer , and turkey industries .',
  'Necrotic enteritis ( NE ) is a serious problem to the poultry farms , which report NE outbreaks more than once per year , as a result of the inappropriate use of antibiotics in the feed .',
  'Mycoplasmal pneumonia caused by Mycoplasma hyopneumoniae is a serious economic problem for swine producers in the United States .',
  'Mycoplasma synoviae ( MS ) remains a serious concern in production of poultry and affects world production of chickens and turkeys .',
  'The increasing resistance of genital mycoplasmas to tetracyclines is a serious problem , since this group of antibiotics is one of the few that is effective against virtually all species of mycoplasmas .',
  'Mycoplasma contamination of cultured cell lines is a serious problem in research , altering cellular response to different stimuli thus compromising experimental results .',
  'It is a serious shortcoming if testing for mycoplasmas is not included in routine bacterial examination of clinical samples .',
  'Experience indicates that mycoplasma contamination is still a serious problem in the cell culture field , with estimates on frequencies of infection varying from 10 % upwards .',
  'Mycoplasma contamination is a serious and frequent problem in the culture laboratory .',
  'CAB-resistant prolactinomas remain a serious concern .',
  'The high isolation rate of mycoplasmas in apparently healthy and clinically sick sheep and goats in this study indicates a carrier status in these SR which may constitute a serious problem in disease control .',
  'Mycoplasma and other bacterial contamination is a serious problem for those involved in cell culture .'],
 'mycoplasmas': ['Cell line contamination is a major drawback of main cell banks of the world and it has cost of losing important biological products or valuable research .',
  'A drawback of the agroinfiltration technique is its temperature dependence : early studies have shown that temperatures above 29 \u2009 ° C are nonpermissive to tumour induction by the bacterium as a result of failure in pilus formation .',
  'This presents a serious concern regarding the risk of mycoplasma contamination for research laboratories and commercial facilities developing and manufacturing cell-derived biological and biopharmaceutical products for therapeutic use .',
  'Mycoplasma gallisepticum ( MG ) has repeatedly emerged as a serious problem in U.S. broiler , layer , and turkey industries .',
  'Necrotic enteritis ( NE ) is a serious problem to the poultry farms , which report NE outbreaks more than once per year , as a result of the inappropriate use of antibiotics in the feed .',
  'Mycoplasmal pneumonia caused by Mycoplasma hyopneumoniae is a serious economic problem for swine producers in the United States .',
  'Mycoplasma synoviae ( MS ) remains a serious concern in production of poultry and affects world production of chickens and turkeys .',
  'The increasing resistance of genital mycoplasmas to tetracyclines is a serious problem , since this group of antibiotics is one of the few that is effective against virtually all species of mycoplasmas .',
  'Mycoplasma contamination of cultured cell lines is a serious problem in research , altering cellular response to different stimuli thus compromising experimental results .',
  'It is a serious shortcoming if testing for mycoplasmas is not included in routine bacterial examination of clinical samples .',
  'Experience indicates that mycoplasma contamination is still a serious problem in the cell culture field , with estimates on frequencies of infection varying from 10 % upwards .',
  'Mycoplasma contamination is a serious and frequent problem in the culture laboratory .',
  'CAB-resistant prolactinomas remain a serious concern .',
  'The high isolation rate of mycoplasmas in apparently healthy and clinically sick sheep and goats in this study indicates a carrier status in these SR which may constitute a serious problem in disease control .',
  'Mycoplasma and other bacterial contamination is a serious problem for those involved in cell culture .'],
 'leishmaniasis': ['This data proves the ability of this system as a promising DNA vaccine carrier for leishmaniasis to cover the main drawback of naked pDNA delivery that is rapid elimination from the circulation .',
  'Zoonotic cutaneous leishmaniasis ( ZCL ) is a serious and increasing public health problem in many rural areas of Iran .',
  'The cutaneous leishmaniasis ( CL ) is a parasitic disease which represents a serious problem for the public health not only in Tunisia but also all over the world .',
  'Due to its morbility and disfiguring scars , cutaneous leishmaniasis is a serious Public Health problem .',
  'Leishmaniasis is a serious health problem in various endemic areas .',
  'Presently , Leishmaniasis is common in most countries of the world and is a serious health problem in the world .',
  'Kala-azar is a serious health problem in India .',
  'Zoonotic Cutaneous Leishmaniasis ( ZCL ) is still a serious health problem in Iran .',
  'The leishmaniasis and Chagas diseases constitute a serious public health problem worldwide with few and ineffective treatment options .',
  'Leishmaniasis is caused by several protozoan species of Leishmania , and being endemically present in 98 countries around the world , it is also a severe public-health problem .',
  'Visceral leishmaniasis ( VL ) is a serious health problem in Iran .',
  'Visceral leishmaniosis ( VL ) remains a serious public health problem in Brazil .',
  'Leishmaniasis is a serious global health problem affecting many people worldwide .',
  'Cutaneous leishmaniasis is currently a serious public health problem in northern Africa , especially in Morocco .',
  'Leishmaniasis remains a severe public health problem and its burden is increasing .',
  'In Brazil , cutaneous leishmaniasis represents a serious public health problem , and chemotherapy is an important element of the clinical management of this disease .',
  'Leishmaniasis is a complex disease that is considered a serious public health problem .',
  'Leishmaniasis is a complex disease caused by protozoan parasite Leishmania and the treatment remains a serious problem since the available drugs exhibited high toxicity and side effects .',
  'Despite the advances in the diagnosis and treatment of leishmaniasis , it is still considered as a severe public health problem particularly in developing countries and a great economic burden on the health resources .',
  'Epidemics of fatal visceral leishmaniasis caused by the intracellular protozoan Leishmania are a severe public health problem in tropical and subtropical regions of the world .',
  'Visceral leishmaniasis is a disease caused by Leishmania ( Leishmania ) chagasi and represents a serious public health problem .',
  'The RESULTS suggest that CVL is widely distributed in Natal , may be increasingly urbanizing and will spread through neighborhoods but not endemic , resulting in a serious public health problem , emphasizing the need for epidemiological studies to a greater understanding of the distribution of canine leishmaniasis in these specific areas and contribute proactively to the public health policies .',
  'Leishmaniasis remains a serious health problem .',
  'Human leishmaniasis , both visceral and cutaneous , has been reported in Morocco for centuries and constitutes a serious public health problem .',
  'Phlebotomine sand flies are considered the main vectors of Leishmania , the causal agents of leishmaniasis , which is a serious emerging public health problem worldwide .',
  'In recent years leishmaniasis has become a serious Public Health problem in Italy .',
  'Canine and human zoonotic leishmaniasis caused by Leishmania infantum , which is transmitted by the bite of infected phlebotomine sand flies , is a serious public health problem in the Mediterranean basin and Latin America .',
  'Pakistan is one of the countries in which cutaneous leishmaniasis is becoming an epidemic disease and because of its morbidity and disfiguring scars , it is considered a serious public health problem .',
  'Antimony-unresponsiveness in visceral leishmaniasis is a serious problem numerically , clinically and economically .',
  'Phlebotomus papatasi ( Diptera : Psychodidae ) is the Old World sand fly vector of zoonotic cutaneous leishmaniasis caused by Leishmania major ( Trypanosomatidae : Kinetoplastida ) , a debilitating and disfiguring protist parasitic disease prevalent throughout southern Mediterranean countries , the Middle East , as well as southern and eastern European countries , where it is regarded as a serious public health problem .',
  'Leishmaniasis represents a severe , increasing , public health problem .',
  'Visceral leishmaniasis presents a serious problem in endemic regions that is difficult to treat or prevent .',
  'Leishmaniasis is considered a serious public health problem in several regions in Brazil and worldwide .',
  'The Indian government proposes to eliminate kala-azar , which has been a serious public health problem in Bihar .',
  'VL in Brazil represents a serious public health problem ; therefore , it is important to study new alternatives to treat infected dogs .',
  'In Brazil , visceral leishmaniasis poses a serious endemic and epidemic problem .',
  'Leishmaniasis is a serious health problem that needs a suitable vaccine delivery system to control the disease .',
  'Leishmaniasis represents a serious health problem worldwide and drug resistance is a growing concern .',
  'Visceral leishmaniasis ( VL ) is an important neglected disease caused by a protozoan parasite , and represents a serious public health problem in many parts of the world .',
  'Zoonotic cutaneous leishmaniasis ( ZCL ) is a serious and increasing public health problem in many parts of Saudi Arabia .',
  'Visceral leishmaniasis ( VL ) is a deadly parasitic diseases caused by Leishmania donovani ; it is a major health problem in many countries .',
  'Cutaneous leishmaniasis ( CL ) is a serious health problem in Suriname .',
  'Visceral leishmaniasis is a serious public health problem on the Indian subcontinent , causing high morbidity and mortality .',
  'Dogs are the main reservoir for visceral leishmaniasis in urban areas , which has become a serious public health concern in Brazil .',
  'In Mexico cutaneous leishmaniasis ( CL ) occurs in 17 of 32 States , and is a serious public health problem .',
  'American tegumentary leishmaniasis ( ATL ) is a widespread anthropozoonosis caused by protozoa of the genus Leishmania and is considered a serious public health problem .',
  'Leishmaniasis is a severe public-health problem , with high rates of morbidity and mortality .',
  'Leishmaniosis is currently considered a serious public health problem and it is listed as a neglected tropical disease by World Health Organization ( WHO ) .',
  'Phlebotomine sand flies are vectors of Leishmania parasites causing different clinical forms of leishmaniases that represent a serious emerging public health problem worldwide .',
  'Leishmaniasis is a serious problem that affects mostly poor countries .',
  'Visceral leishmaniasis ( VL ) is a vector-borne disease affecting humans and domestic animals that constitutes a serious public health problem in many countries .',
  'Several animal models have been established to study visceral leishmaniosis ( VL ) , a worldwide vector-borne disease affecting humans and domestic animals that constitutes a serious public health problem .',
  'Leishmaniasis , a neglected tropical disease caused by parasites of the genus Leishmania , causes a serious burden of disease around the world , represents a threat to the life of millions of people , and therefore is a major public health problem .',
  'Visceral leishmaniasis ( VL ) still represents a serious public health problem in Brazil due to the inefficiency of the control measures currently employed , that included early diagnosis and treatment of human cases , vector control , euthanasia of infected dogs and , recently approved in Brazil , treatment with Milteforam drug .',
  'Cutaneous leishmaniasis due to Leishmania major is a serious and increasing problem affecting many rural areas of 17 out of 31 provinces in Iran .',
  'Antimony unresponsiveness in mucocutaneous and visceral leishmaniasis is a serious clinical problem .',
  'Species of the genus Leishmania ( Kinetoplastida , Trypanosomatidae ) are causative agents of leishmaniasis , a complex disease with variable clinical spectrum and epidemiological diversity , constituting , in some countries , a serious public health problem .',
  'Zoonotic cutaneous leishmaniasis ( ZCL ) constitutes a serious public health problem in many parts of the world including Iran .',
  'Visceral Leishmaniasis or Kala-azar ( KA ) is a serious health concern in India .',
  'A model district action plan for control of Visceral Leishmaniasis a serious public health problem in north-east Bihar was developed in late 1989 and implemented in 1992 in district Vaishali .',
  'Leishmaniasis is a serious public health problem in Yemen .',
  'Cutaneous leishmaniasis ( CL ) is a serious public health problem in many tropical and subtropical regions of the world .',
  'Human visceral leishmaniasis is a serious public health problem in endemic countries because of its high potential lethality , particularly in children .',
  'Leishmaniasis is a serious health problem in some parts of the world .',
  'Leishmaniasis constitutes a severe public health problem , with an estimated prevalence of 12 million cases .',
  'Currently , the therapy is toxic , expensive and the resistance has emerged as a serious problem , which has compelled the search for new antileishmanial agents .',
  'Leishmaniasis , one of the most neglected diseases , is a serious public health problem in many countries , including Brazil .',
  'Unresponsiveness of Leishmania spp . to antimonial drugs is a serious problem in some endemic areas .',
  'Visceral leishmaniasis ( VL ) is a deadly neglected tropical disease that poses a serious problem in various countries all over the world .',
  'In Brazil , visceral leishmaniasis ( VL ) is a serious public health problem because of its magnitude , geographical expansion and potential harms caused by illnesses , including death .',
  'Zoonotic visceral leishmaniasis ( ZVL ) is a serious public health problem in several Brazilian cities .',
  'Caused by infection with Leishmania donovani or L. infantum , VL represents a serious public health problem in endemic regions and is rapidly emerging as an opportunistic infection in HIV patients .',
  'Leishmaniasis , a category 1 disease , has remained neglected for decades , and therefore , has developed into a severe health problem worldwide .',
  'Leishmaniasis remains a serious public health problem in several parts of the developing world .',
  'Leishmaniasis is a serious health problem in several parts of the world , and localized cutaneous leishmaniasis ( LCL ) is the most frequent presentation of the tegumentary form of this disease cluster .',
  'Visceral leishmaniasis is a serious public health problem .',
  'Infection with Leishmania infantum causes the disease visceral leishmaniasis ( VL ) , which is a serious clinical and veterinary problem .',
  'Leishmaniosis , caused by intracellular parasites of the genus Leishmania , has become a serious public health problem around the world , and for which there are currently extensive limitations .',
  'The increasing rates of antimony resistance are becoming a serious health problem in treatment of anthroponotic cutaneous leishmaniasis ( ACL ) .',
  'The control of leishmaniasis remains a serious problem .',
  'In Peru , leishmaniasis is a metaxenic disease that represents a serious public health problem , due to its wide distribution and the number of people in danger of contracting the disease , being the vulnerable population mainly those with low economic resources .',
  'Visceral leishmaniasis is a serious public health problem that requires global control strategies , especially with respect to factors that may intervene in reducing the incidence of endemicity .',
  'Leishmaniasis from Leishmania infantum is a parasitary zoonotic disease and a serious problem to public health .',
  'Cutaneous Leishmaniasis is a serious public health problem , typically affecting poor populations with limited access to health care .',
  'Visceral leishmaniasis ( VL ) remains a serious public health problem in China .',
  'For example , leishmaniosis has become into a serious Third World problem .',
  'Visceral leishmaniasis is a serious public health problem in Brazil , and control of this disease constitutes a major challenge .',
  'Resistance to pentavalent antimonial drugs has become a serious problem in the treatment of cutaneous leishmaniasis in some endemic areas .',
  'Visceral leishmaniasis ( VL ) represents a serious public health problem , as Leishmania infantum is one of main disease causative agents in the Americas .',
  'Although visceral leishmaniasis disease is controlled overall in China , it remains a serious public health problem and remains fundamentally uncontrolled in Jiashi County , Xinjiang Uygur Autonomous Region .',
  'Visceral leishmaniasis , or kala-azar , is recognised as a serious emerging public health problem in India .',
  'The parasitic protozoan Leishmania is the aetiological agent of a spectrum of clinical diseases , ranging from disfiguring skin lesions to life-threatening visceral infection , and is a serious health problem in tropical and subtropical areas world-wide .',
  'Leishmaniasis remains a serious public health problem in developing countries without effective control , whether by vaccination or chemotherapy .',
  'Leishmaniasis is a serious health problem in many countries , and continues expanding to new geographic areas including Europe and USA .',
  'Among neglected tropical diseases , visceral leishmaniasis ( VL ) shows great relevance in global terms and is a serious public health concern due to the possibility of severe and lethal forms in humans .',
  'Human leishmaniasis is a severe health problem in many countries around the world .',
  'Visceral Leishmaniasis ( VL ) is an infectious disease which constitutes a serious public health problem , integrating the list of neglected tropical diseases .',
  'Leishmania ( Viannia ) braziliensis is the major causative agent of American tegumentary leishmaniasis , a disease that has a wide geographical distribution and is a severe public health problem .',
  'In India , it is a serious problem in Bihar , West Bengal and eastern Uttar Pradesh where there is under-reporting of kala-azar and post kala-azar dermal leishmaniasis in women and children 0 - 9 years of age .',
  'Visceral leishmaniasis remains a serious public health problem in developing countries .',
  'Cutaneous leishmaniasis ( CL ) remains a serious public health concern in Kerman Province , eastern Iran .',
  'Leishmaniasis is considered a serious public health problem and the current available therapy has several disadvantages , which makes the search for new therapeutic targets and alternative treatments extremely necessary .'],
 'climate': ['This mode of CO2 release will prevent acidification of the seawater around the release point , which is a major environmental drawback of ocean sequestration of liquid , unemulsified CO2 .',
  'Increased CO2 in the atmosphere is such a serious problem for mankind that many research and development approaches are implemented to reduce CO2 emissions .',
  'Global climate change is a vexing economic , environmental , and public health problem .',
  'Global warming is a serious problem facing the world today .',
  'Atmospheric greenhouse gas ( GHG ) concentration increases are a serious problem impacting global climate .',
  'Climate change is a serious global problem , and the majority of greenhouse gas emissions come from industries that are enabled by engineers and represented by the engineering professional institutions .',
  'CH(4 ) has a global warming potential 21 times greater than CO(2 ) ; thus , it poses a serious environmental problem .',
  'The signs of climate change are undeniable , and the inevitable impact for Earth and all its inhabitants is a serious concern .',
  "This leads to a severe concern that decomposition of soil organic carbon ( SOC ) previously stored in this region , which accounts for about 50 % of the world 's SOC storage , will cause positive feedback that accelerates climate warming .",
  'With the rapid development of metropolises worldwide , the urban heat island ( UHI ) effect is becoming a serious environmental problem in recent years .',
  'Hypothermia is considered a serious problem in big cities .',
  'Energy generation is currently a serious concern in the progress of human civilization .',
  'The impact of climate change on human health is a serious concern .',
  'Increase in concentrations of various greenhouse gases and their possible contributions to the global warming are becoming a serious concern .',
  'With climate modeling predicting a raise of at least 2 ° C by year 2100 , the fate of ice has become a serious concern , but we still do not understand how ice grows ( or melts ) .',
  'Even relatively conservative assumptions put a severe upward pressure on forecast global energy demand and highlight three areas of concern .',
  'Elevated atmospheric CO₂ concentration is a serious global environmental problem .',
  'Americans do exhibit some differences , placing lower priority on the environment and global warming , and with fewer believing that " global warming has been established as a serious problem and immediate action is necessary " .',
  'Frost presents a serious problem for the human environment , resulting in such phenomena as downed power lines , damaged crops and stalled aircraft .',
  "LCC is a serious problem in the Earth science domain for this impacts the regional climate by modifying the distribution of terrestrial carbon stocking and roughness of the Earth 's surface .",
  'The urban heat island effect has become a serious environmental problem with the expansion of cities and industrial areas .',
  'Ice formation is a catastrophic problem affecting our daily life in a number of ways .',
  'City-scale warming is becoming a serious problem in terms of human health .',
  'However , climate change , with its associated negative health effects , also constitutes a worrisome problem .',
  'The short-term effects of high temperatures are a serious concern in the context of climate change .',
  'As much as energy supply remains a major challenge in most of the African countries , the compounding environmental effect of energy consumption has continued to be a serious concern to policymakers and environmental stakeholders .',
  'Accumulation of greenhouse gases especially CO2 in the atmosphere leading to global warming with undesirable climate changes has been a serious global concern .',
  'Experiencing a Severe Weather Event Increases Concern About Climate Change .',
  'This dynamic loss is a serious concern , with some modelling studies suggesting that the collapse of a major ice sheet could be imminent or potentially underway in West Antarctica , but others predicting a more limited response .',
  'However , the simultaneous formation of CO2 is a serious problem .',
  'The increase in greenhouse gas emissions is a serious environmental problem and has stimulated the scientific community to pay attention to the need for detection and monitoring of gases released into the atmosphere .',
  'Global warming caused by the increasing CO2 concentration in atmosphere is a serious problem in the international political , economic , scientific and environmental fields in recent years .'],
 'warming': ['This mode of CO2 release will prevent acidification of the seawater around the release point , which is a major environmental drawback of ocean sequestration of liquid , unemulsified CO2 .',
  'Increased CO2 in the atmosphere is such a serious problem for mankind that many research and development approaches are implemented to reduce CO2 emissions .',
  'Global climate change is a vexing economic , environmental , and public health problem .',
  'Global warming is a serious problem facing the world today .',
  'Atmospheric greenhouse gas ( GHG ) concentration increases are a serious problem impacting global climate .',
  'Climate change is a serious global problem , and the majority of greenhouse gas emissions come from industries that are enabled by engineers and represented by the engineering professional institutions .',
  'CH(4 ) has a global warming potential 21 times greater than CO(2 ) ; thus , it poses a serious environmental problem .',
  'The signs of climate change are undeniable , and the inevitable impact for Earth and all its inhabitants is a serious concern .',
  "This leads to a severe concern that decomposition of soil organic carbon ( SOC ) previously stored in this region , which accounts for about 50 % of the world 's SOC storage , will cause positive feedback that accelerates climate warming .",
  'With the rapid development of metropolises worldwide , the urban heat island ( UHI ) effect is becoming a serious environmental problem in recent years .',
  'Hypothermia is considered a serious problem in big cities .',
  'Energy generation is currently a serious concern in the progress of human civilization .',
  'The impact of climate change on human health is a serious concern .',
  'Increase in concentrations of various greenhouse gases and their possible contributions to the global warming are becoming a serious concern .',
  'With climate modeling predicting a raise of at least 2 ° C by year 2100 , the fate of ice has become a serious concern , but we still do not understand how ice grows ( or melts ) .',
  'Even relatively conservative assumptions put a severe upward pressure on forecast global energy demand and highlight three areas of concern .',
  'Elevated atmospheric CO₂ concentration is a serious global environmental problem .',
  'Americans do exhibit some differences , placing lower priority on the environment and global warming , and with fewer believing that " global warming has been established as a serious problem and immediate action is necessary " .',
  'Frost presents a serious problem for the human environment , resulting in such phenomena as downed power lines , damaged crops and stalled aircraft .',
  "LCC is a serious problem in the Earth science domain for this impacts the regional climate by modifying the distribution of terrestrial carbon stocking and roughness of the Earth 's surface .",
  'The urban heat island effect has become a serious environmental problem with the expansion of cities and industrial areas .',
  'Ice formation is a catastrophic problem affecting our daily life in a number of ways .',
  'City-scale warming is becoming a serious problem in terms of human health .',
  'However , climate change , with its associated negative health effects , also constitutes a worrisome problem .',
  'The short-term effects of high temperatures are a serious concern in the context of climate change .',
  'As much as energy supply remains a major challenge in most of the African countries , the compounding environmental effect of energy consumption has continued to be a serious concern to policymakers and environmental stakeholders .',
  'Accumulation of greenhouse gases especially CO2 in the atmosphere leading to global warming with undesirable climate changes has been a serious global concern .',
  'Experiencing a Severe Weather Event Increases Concern About Climate Change .',
  'This dynamic loss is a serious concern , with some modelling studies suggesting that the collapse of a major ice sheet could be imminent or potentially underway in West Antarctica , but others predicting a more limited response .',
  'However , the simultaneous formation of CO2 is a serious problem .',
  'The increase in greenhouse gas emissions is a serious environmental problem and has stimulated the scientific community to pay attention to the need for detection and monitoring of gases released into the atmosphere .',
  'Global warming caused by the increasing CO2 concentration in atmosphere is a serious problem in the international political , economic , scientific and environmental fields in recent years .'],
 'co2': ['This mode of CO2 release will prevent acidification of the seawater around the release point , which is a major environmental drawback of ocean sequestration of liquid , unemulsified CO2 .',
  'Increased CO2 in the atmosphere is such a serious problem for mankind that many research and development approaches are implemented to reduce CO2 emissions .',
  'Global climate change is a vexing economic , environmental , and public health problem .',
  'Global warming is a serious problem facing the world today .',
  'Atmospheric greenhouse gas ( GHG ) concentration increases are a serious problem impacting global climate .',
  'Climate change is a serious global problem , and the majority of greenhouse gas emissions come from industries that are enabled by engineers and represented by the engineering professional institutions .',
  'CH(4 ) has a global warming potential 21 times greater than CO(2 ) ; thus , it poses a serious environmental problem .',
  'The signs of climate change are undeniable , and the inevitable impact for Earth and all its inhabitants is a serious concern .',
  "This leads to a severe concern that decomposition of soil organic carbon ( SOC ) previously stored in this region , which accounts for about 50 % of the world 's SOC storage , will cause positive feedback that accelerates climate warming .",
  'With the rapid development of metropolises worldwide , the urban heat island ( UHI ) effect is becoming a serious environmental problem in recent years .',
  'Hypothermia is considered a serious problem in big cities .',
  'Energy generation is currently a serious concern in the progress of human civilization .',
  'The impact of climate change on human health is a serious concern .',
  'Increase in concentrations of various greenhouse gases and their possible contributions to the global warming are becoming a serious concern .',
  'With climate modeling predicting a raise of at least 2 ° C by year 2100 , the fate of ice has become a serious concern , but we still do not understand how ice grows ( or melts ) .',
  'Even relatively conservative assumptions put a severe upward pressure on forecast global energy demand and highlight three areas of concern .',
  'Elevated atmospheric CO₂ concentration is a serious global environmental problem .',
  'Americans do exhibit some differences , placing lower priority on the environment and global warming , and with fewer believing that " global warming has been established as a serious problem and immediate action is necessary " .',
  'Frost presents a serious problem for the human environment , resulting in such phenomena as downed power lines , damaged crops and stalled aircraft .',
  "LCC is a serious problem in the Earth science domain for this impacts the regional climate by modifying the distribution of terrestrial carbon stocking and roughness of the Earth 's surface .",
  'The urban heat island effect has become a serious environmental problem with the expansion of cities and industrial areas .',
  'Ice formation is a catastrophic problem affecting our daily life in a number of ways .',
  'City-scale warming is becoming a serious problem in terms of human health .',
  'However , climate change , with its associated negative health effects , also constitutes a worrisome problem .',
  'The short-term effects of high temperatures are a serious concern in the context of climate change .',
  'As much as energy supply remains a major challenge in most of the African countries , the compounding environmental effect of energy consumption has continued to be a serious concern to policymakers and environmental stakeholders .',
  'Accumulation of greenhouse gases especially CO2 in the atmosphere leading to global warming with undesirable climate changes has been a serious global concern .',
  'Experiencing a Severe Weather Event Increases Concern About Climate Change .',
  'This dynamic loss is a serious concern , with some modelling studies suggesting that the collapse of a major ice sheet could be imminent or potentially underway in West Antarctica , but others predicting a more limited response .',
  'However , the simultaneous formation of CO2 is a serious problem .',
  'The increase in greenhouse gas emissions is a serious environmental problem and has stimulated the scientific community to pay attention to the need for detection and monitoring of gases released into the atmosphere .',
  'Global warming caused by the increasing CO2 concentration in atmosphere is a serious problem in the international political , economic , scientific and environmental fields in recent years .'],
 'nitrate': ['Deammonification ( partial nitritation-anammox ) is a proven process for the treatment of high-nitrogen waste streams , but long startup time is a known drawback of this technology .',
  'Large nutrient losses to groundwater and surface waters are a major drawback of the highly productive agricultural sector in The Netherlands .',
  'Nitrogen accumulation is a serious environmental problem in freshwater ponds , which can lead to massive death of fish and shrimps as well as the eutrophication .',
  'Typically up to 70 % of ingested protein-N is excreted representing a loss of productivity potential and a serious environmental problem in terms of nitrogenous pollution of lands and water .',
  'The impurity poses a serious problem for an accurate measurement of the oxygen isotope compositions for atmospheric sulfate , since atmospheric nitrate bears extremely positive Delta17O and delta18O values .',
  'Anthropogenic nitrate contamination is a serious problem in many natural environments .',
  'The reactive nitrogen ( Nr ) pollution is a serious environmental problem .',
  'The presence of elevated concentrations of nitrates in drinking water has become a serious concern worldwide .',
  'Nitrogen contamination is a global concern and has been a serious problem in agricultural areas .',
  'Nitrate pollution in groundwater is a serious problem in many parts of the world .',
  'The elevated level of nitrate in groundwater is a serious problem in Korean agricultural areas .',
  'The environmental and health effects caused by nitrate contamination of aquatic systems are a serious problem throughout the world .',
  'Nitrate ( NO(3-)N ) contamination of drinking groundwater is a serious worldwide problem .',
  'Nitrate pollution in aquatic systems caused by intensive agricultural activities is a serious problem in the Sanjiang Plain .',
  'Tolerance to the organic nitrates is a vexing problem .',
  'Nitrate and nitrite contamination of surface waters ( e.g. lakes ) has become a severe environmental and health problem , especially in developing countries .',
  'Atmospheric N deposition is a serious problem in subtropical China where N is present in large amounts but P is deficient .',
  'Inorganic pollutants in groundwater , such as sulfate and nitrate , have been a serious problem in China for decades .',
  'The presence of nitrate in water and wastewater is a serious environmental problem .',
  'Nitrate NO(3)(- ) contamination of groundwater resources is a serious problem .',
  'Excess nitrogen ( N ) is a serious water-quality problem in most of the estuaries in the United States , especially those downstream of developed coastal basins .',
  'Substantial loss of ammonia can reduce the nutrient value of the compost product and may lead to a severe odor problem in the composting facility .',
  'Agricultural contributions of nitrogen are a serious concern for many water resources and have spurred the implementation of riparian buffer zones to reduce groundwater nitrate ( NO ) .',
  'The nitrate concentration of surface has become a serious concern in agricultural industry through out the world .',
  'Nitrate is a serious contaminant of ground and surface water , which cause high concern in the field of health and environmental protection .',
  'Discharge of nitrogen ( N ) from fertilizers applied to vegetables is becoming a serious environmental problem .',
  'A considerable increase in nitrate concentration in groundwater has become a serious concern worldwide .',
  'Nitrate ( NO3(- ) ) pollution is a severe problem in aquatic systems in Taihu Lake Basin in China .',
  'Nitrate is a serious problem in closed-circuit public aquariums because its accumulation rapidly becomes toxic to many lifeforms .'],
 'nitrogen': ['Deammonification ( partial nitritation-anammox ) is a proven process for the treatment of high-nitrogen waste streams , but long startup time is a known drawback of this technology .',
  'Large nutrient losses to groundwater and surface waters are a major drawback of the highly productive agricultural sector in The Netherlands .',
  'Nitrogen accumulation is a serious environmental problem in freshwater ponds , which can lead to massive death of fish and shrimps as well as the eutrophication .',
  'Typically up to 70 % of ingested protein-N is excreted representing a loss of productivity potential and a serious environmental problem in terms of nitrogenous pollution of lands and water .',
  'The impurity poses a serious problem for an accurate measurement of the oxygen isotope compositions for atmospheric sulfate , since atmospheric nitrate bears extremely positive Delta17O and delta18O values .',
  'Anthropogenic nitrate contamination is a serious problem in many natural environments .',
  'The reactive nitrogen ( Nr ) pollution is a serious environmental problem .',
  'The presence of elevated concentrations of nitrates in drinking water has become a serious concern worldwide .',
  'Nitrogen contamination is a global concern and has been a serious problem in agricultural areas .',
  'Nitrate pollution in groundwater is a serious problem in many parts of the world .',
  'The elevated level of nitrate in groundwater is a serious problem in Korean agricultural areas .',
  'The environmental and health effects caused by nitrate contamination of aquatic systems are a serious problem throughout the world .',
  'Nitrate ( NO(3-)N ) contamination of drinking groundwater is a serious worldwide problem .',
  'Nitrate pollution in aquatic systems caused by intensive agricultural activities is a serious problem in the Sanjiang Plain .',
  'Tolerance to the organic nitrates is a vexing problem .',
  'Nitrate and nitrite contamination of surface waters ( e.g. lakes ) has become a severe environmental and health problem , especially in developing countries .',
  'Atmospheric N deposition is a serious problem in subtropical China where N is present in large amounts but P is deficient .',
  'Inorganic pollutants in groundwater , such as sulfate and nitrate , have been a serious problem in China for decades .',
  'The presence of nitrate in water and wastewater is a serious environmental problem .',
  'Nitrate NO(3)(- ) contamination of groundwater resources is a serious problem .',
  'Excess nitrogen ( N ) is a serious water-quality problem in most of the estuaries in the United States , especially those downstream of developed coastal basins .',
  'Substantial loss of ammonia can reduce the nutrient value of the compost product and may lead to a severe odor problem in the composting facility .',
  'Agricultural contributions of nitrogen are a serious concern for many water resources and have spurred the implementation of riparian buffer zones to reduce groundwater nitrate ( NO ) .',
  'The nitrate concentration of surface has become a serious concern in agricultural industry through out the world .',
  'Nitrate is a serious contaminant of ground and surface water , which cause high concern in the field of health and environmental protection .',
  'Discharge of nitrogen ( N ) from fertilizers applied to vegetables is becoming a serious environmental problem .',
  'A considerable increase in nitrate concentration in groundwater has become a serious concern worldwide .',
  'Nitrate ( NO3(- ) ) pollution is a severe problem in aquatic systems in Taihu Lake Basin in China .',
  'Nitrate is a serious problem in closed-circuit public aquariums because its accumulation rapidly becomes toxic to many lifeforms .'],
 'groundwater': ['Deammonification ( partial nitritation-anammox ) is a proven process for the treatment of high-nitrogen waste streams , but long startup time is a known drawback of this technology .',
  'Large nutrient losses to groundwater and surface waters are a major drawback of the highly productive agricultural sector in The Netherlands .',
  'A drawback of As(III ) detection using square wave anodic stripping voltammetry ( SWASV ) is that it is susceptible to interferences from various metals or organic compounds , especially in real sample water .',
  'Arsenic ( As ) contamination is a severe problem in the intertidal zones of the Bohai Sea ( China ) with wide salinity variation .',
  'Nitrogen accumulation is a serious environmental problem in freshwater ponds , which can lead to massive death of fish and shrimps as well as the eutrophication .',
  'Arsenic poisoning from drinking groundwater is a serious problem , particularly in developing Asian countries .',
  'Arsenic in drinking water is a serious problem for human health .',
  'This is a serious global health problem because arsenic is a Group 1 ( proven ) human carcinogen and chronic exposure is known to cause skin , lung , and bladder tumors .',
  'Arsenic ( As ) contamination in soil and groundwater has become a serious problem to public health .',
  'Typically up to 70 % of ingested protein-N is excreted representing a loss of productivity potential and a serious environmental problem in terms of nitrogenous pollution of lands and water .',
  'The impurity poses a serious problem for an accurate measurement of the oxygen isotope compositions for atmospheric sulfate , since atmospheric nitrate bears extremely positive Delta17O and delta18O values .',
  'Groundwater pollution by arsenic is a serious worldwide problem , especially in Asian countries .',
  'Phytotoxicity of aluminum ( Al ) has become a serious problem in inhibiting plant growth on acid soils .',
  'A severe reoccurrence of AR was found in 2 of the 10 AR problem farms .',
  'The deactivation of selective catalytic reduction ( SCR ) catalysts by arsenic is a serious problem for NH',
  'Arsenic ( As ) contamination of the environment has emerged as a serious problem .',
  'Arsenic , in drinking water is a serious concern .',
  'Anthropogenic nitrate contamination is a serious problem in many natural environments .',
  'The reactive nitrogen ( Nr ) pollution is a serious environmental problem .',
  'Arsenic pollution in soil has been a serious problem all over the world .',
  'Arsenic-contaminated drinking water is known to be a serious human health problem .',
  'Arsenic contamination of ground water has become a serious problem all over the world .',
  'Arsenic contamination in groundwater from crystalline basement rocks in West Africa has only been documented in isolated areas and presents a serious health threat in a region already facing multiple challenges related to water quality and scarcity .',
  'Phytotoxicity of aluminum ion ( Al3 + ) is a serious problem limiting crop production on acid soils .',
  'The presence of elevated concentrations of nitrates in drinking water has become a serious concern worldwide .',
  'Arsenic in groundwater is a serious problem in New England , particularly for domestic well owners drawing water from bedrock aquifers .',
  'This study revealed that aluminum toxicity is a serious harmful problem for rice crop productivity in acid soil .',
  'A serious problem in extracting IAA from plant tissues is the considerable loss .',
  'Contamination of arsenic ( As ) in rice ( Oryza sativa L. ) paddies and subsequent uptake by rice plants is a serious concern , because rice is a staple crop for millions of people .',
  'Arsenic contamination in water bodies is a serious problem and causes various health problems due to which US Environment Protection Agency ( USEPA ) set its maximum permissible limit of 10 \xa0 ppb .',
  'Nitrogen contamination is a global concern and has been a serious problem in agricultural areas .',
  'Chronic exposure to arsenic is a serious problem to human health .',
  '• Strategies to reduce arsenic ( As ) in rice grain , below concentrations that represent a serious human health concern , require that the mechanisms of As accumulation within grain be established .',
  'Contamination of drinking water by arsenic and other heavy metals and their related toxicology is a serious concern now-a-days .',
  'The neurotoxicity of arsenic is a serious health problem , especially for children .',
  'Nitrate pollution in groundwater is a serious problem in many parts of the world .',
  'Naturally occurring arsenic in groundwater in Cambodia is a serious health concern .',
  'Though , little is known about the effects of arsenical on leukemia resistant to chemotherapy , emerging as a serious clinical problem .',
  'In Morocco , acute aluminum phosphide poisoning ( AAlPP ) is a serious health care problem .',
  'Residual dissolved aluminum ( Al ) in drinking water is becoming a serious concern due to its high potential risks to human health .',
  'Arsenic contamination is a serious problem in rice cultivated soils of many developing countries .',
  'The elevated level of nitrate in groundwater is a serious problem in Korean agricultural areas .',
  'The environmental and health effects caused by nitrate contamination of aquatic systems are a serious problem throughout the world .',
  'The toxicity of aluminium in dialysis patients was a serious problem for haemodialysis units in the seventies and eighties of the last century .',
  'Accumulation of arsenic in plants is a serious South-east Asian environmental problem .',
  "In this project , our goal was to assess Bangladeshi research participants ' attitudes towards receiving information regarding genetic susceptibility to the effects of consuming arsenic-contaminated drinking water , a serious environmental health concern in Bangladesh and other countries .",
  'Groundwater arsenic contamination has become a serious global concern due to its adverse effects on human health .',
  'Exposure to arsenic via drinking water is a serious health concern in the US .',
  'Arsenic contamination of drinking water is a serious water quality problem in many parts of the world .',
  'Arsenic ( As ) is naturally occurring toxic metalloid which is considered as a serious environmental and health concern .',
  'Water sources pollution by arsenic ions is a serious environmental problem all around the world .',
  'The extensive extraction of arsenic (As)-contaminated groundwaters for drinking , household and agricultural purposes represents a serious health concern in many districts of Bangladesh .',
  'Arsenic toxicity is a serious global health concern since over 200 million people are chronically exposed worldwide .',
  'Nitrate ( NO(3-)N ) contamination of drinking groundwater is a serious worldwide problem .',
  'Globally , arsenic contaminated groundwater is a serious concern for human health .',
  'Arsenicosis became a serious problem for the affected communities .',
  'Nitrate pollution in aquatic systems caused by intensive agricultural activities is a serious problem in the Sanjiang Plain .',
  'Pollution of antimony ( Sb ) raises a serious environmental problem .',
  'Phenyl substituted arsenic compounds are widely used as feed additives in the poultry industry and have become a serious environmental concern .',
  'Elevated arsenic concentration in the environment and agricultural soil is a serious concern to crop production and human health .',
  'Arsenic exposure was a serious health problem in the region .',
  'Arsenic (As)-polluted groundwater constitutes a serious problem for peanut plants , as roots can accumulate the metalloid in their edible parts .',
  'The present data suggested that exposure to arsenic is associated with an increased prevalence of underweight , a serious health problem in developing countries , which in turn is associated with increased skin manifestation of arsenic poisoning .',
  'The contamination of arsenic in human drinking water supplies is a serious global health concern .',
  'High concentration of arsenic ( As ) in rice is a serious problem worldwide .',
  'Arsenic ( As ) contamination of rice grain is a serious problem worldwide .',
  'Arsenic created a serious public health problem in Bangladesh due to its presence in groundwater and dissemination of the toxic effects to millions of people .',
  'Tolerance to the organic nitrates is a vexing problem .',
  'Nitrate and nitrite contamination of surface waters ( e.g. lakes ) has become a severe environmental and health problem , especially in developing countries .',
  'Exposure to arsenic and its compounds was a serious problem in one of the plants .',
  'Human exposure to drinking water contaminated with arsenic is a serious global health concern and it predisposes people to cardiovascular diseases , such as hypertension , atherosclerosis , and microvascular diseases .',
  'Atmospheric N deposition is a serious problem in subtropical China where N is present in large amounts but P is deficient .',
  'Arsenic contamination of the groundwater in the Hetao area in Inner Mongolia , China , has been a serious problem since the 1980s .',
  'Elevated Al concentration in water of this aquifer is described as a serious health concern when used for the household water supply .',
  'Inorganic pollutants in groundwater , such as sulfate and nitrate , have been a serious problem in China for decades .',
  'Arsenic pollution of groundwater is a serious problem in many regions of Latin America that causes severe risks to human health .',
  'In the Red River Delta , Vietnam , arsenic ( As ) contamination of groundwater is a serious problem where more than seventeen million people are affected .',
  'Arsenic concentrations of tubewell water that exceed acceptable limits poses a serious health problem in Bangladesh .',
  'Arsenic poisoning continues to be a serious medical problem that may easily be overlooked or misdiagnosed .',
  "Water contamination particularly ground water contamination with arsenic is a serious problem in today 's scenario since arsenic is associated with several kinds of health problems , such arsenic associated health anomalies are commonly called as ' Arsenism ' .",
  'Toxicity of aluminum ( Al ) is a serious problem for agricultural plants , especially due to excessive soil acidification caused by continuous intensive agriculture and modified environmental conditions related with global climate change .',
  'The presence of arsenic in drinking water has been a serious health problem in many countries .',
  'Arsenic exposure via drinking water is a serious environmental health concern .',
  'The presence of nitrate in water and wastewater is a serious environmental problem .',
  'Arsenic ( As ) contamination of the groundwater in the Mekong Delta is a serious problem affecting millions of people who rely on this important resource for drinking and agriculture .',
  'The environmental contaminant arsenic causes cancer , developmental retardation , and other degenerative diseases and , thus , is a serious health concern worldwide .',
  'Nitrate NO(3)(- ) contamination of groundwater resources is a serious problem .',
  'Arsenic contamination in soil is a serious problem affecting both site use and groundwater quality .',
  'Arsenic contamination of soil and groundwater is a serious problem worldwide .',
  'Arsenic trioxide ( arsenite , As(III ) ) has shown a remarkable clinical efficacy , whereas its side effects are still a serious concern .',
  'Excess nitrogen ( N ) is a serious water-quality problem in most of the estuaries in the United States , especially those downstream of developed coastal basins .',
  'Arsenic is a toxic metalloid widely present in nature , and arsenic poisoning in drinking water is a serious global public problem .',
  'Arsenic ( As ) contamination of water is a serious problem in developing countries .',
  'The high toxicity of arsenic derivatives converts this element in a serious problem of public health worldwide .',
  'In India , acute aluminium phosphide poisoning ( AAlPP ) is a serious health care problem .',
  'Microbe-mediated redox transformation of arsenic ( As ) leading to its mobilization has become a serious environmental concern in various subsurface ecosystems especially within the alluvial aquifers .',
  'Substantial loss of ammonia can reduce the nutrient value of the compost product and may lead to a severe odor problem in the composting facility .',
  'Loss of cognitive function due to arsenic exposure is a serious health concern in many parts of the world , including China .',
  'Agricultural contributions of nitrogen are a serious concern for many water resources and have spurred the implementation of riparian buffer zones to reduce groundwater nitrate ( NO ) .',
  'The nitrate concentration of surface has become a serious concern in agricultural industry through out the world .',
  'Studies have shown a significant form of toxic As ( III ) being released through the reductive dissolution of iron-oxy/hydroxide minerals and microbial reduction mechanisms , which leads to a serious health concern .',
  'Arsenic ( As ) pollution is a serious concern worldwide .',
  'Arsenic toxicity is a serious public health problem worldwide that brings more than 100 million people into the risk of arsenic exposure from groundwater and food contamination .',
  'Diabetes is a menacing problem , particularly to inhabitants of groundwater arsenic contaminated areas needing new medical approaches .',
  'Arsenic contamination has become a menacing health concern , warranting search for new drugs capable of ameliorating its toxicity .',
  'Nitrate is a serious contaminant of ground and surface water , which cause high concern in the field of health and environmental protection .',
  'Discharge of nitrogen ( N ) from fertilizers applied to vegetables is becoming a serious environmental problem .',
  'Chronic arsenic toxicity is a serious environmental health problem across the world .',
  'Soil contamination with co-existing arsenic ( As ) and antimony ( Sb ) has become a serious environmental problem worldwide .',
  'Arsenic ( As ) in rice grains is a serious food safety concern .',
  'The exposure of paddy fields to arsenic ( As ) through groundwater irrigation is a serious concern that may not only lead to As accumulation to unacceptable levels but also interfere with mineral nutrients in rice grains .',
  'Arsenic in drinking water presents a serious public health problem in Serbia , but its relationship with diabetes has not been studied previously .',
  'A considerable increase in nitrate concentration in groundwater has become a serious concern worldwide .',
  'Arsenic contamination of groundwater is a serious concern worldwide .',
  'Arsenic ( As ) contamination has emerged as a serious public health concern worldwide because of its accumulation and mobility through the food chain .',
  'Nitrate ( NO3(- ) ) pollution is a severe problem in aquatic systems in Taihu Lake Basin in China .',
  'Nitrate is a serious problem in closed-circuit public aquariums because its accumulation rapidly becomes toxic to many lifeforms .',
  'In recent years , the arsenic contamination of the herb and its relative products becomes a serious problem due to elevated soil As concentration .',
  'Arsenic contamination in groundwater is a severe global problem , most notably in Southeast Asia where millions suffer from acute and chronic arsenic poisoning .',
  'Soil arsenic ( As ) contamination is a serious concern because of its mark negative impacts on plant growth and physiological processes .',
  'Human exposure to drinking water contaminated with arsenic is a serious global health concern and predisposes to cardiovascular disease states , such as hypertension , atherosclerosis , and microvascular disease .',
  'Aluminum ( Al ) toxicity is a serious problem for rice crop productivity in acidic soils worldwide .',
  'The ubiquitous presence of arsenic ( a toxic metalloid ) in our environment , particularly in our drinking water , is a serious health hazard of global concern .'],
 'internet': ['A major drawback of existing health games is that they are not very well described and attributed with ( machine-readable , quantitative , and qualitative ) metadata such as the characterizing goal of the game , the target user group , or expected health effects well proven in scientific studies .',
  'Internet addition disorder ( IAD ) is currently becoming a serious mental health problem among Chinese adolescents .',
  'As excessive use of internet gaming has become a serious public health concern , increasing studies have revealed that impulsivity is one of the important risk factors of internet gaming disorder ( IGD ) .',
  'Problematic online game use ( POGU ) has become a serious global public health concern among adolescents .',
  'Excessive computer game playing ( ECGP ) has already become a serious social problem .',
  'The results of the study are in accordance with our previous findings on Internet use and mental health , confirming that Internet addiction is a potentially a serious public health problem .',
  'Internet addiction among college students has become a serious problem in China .',
  'Internet addiction is a serious problem , and the incidence has increased significantly in recent years .',
  'Internet addiction ( IA ) is currently becoming a serious mental health problem .',
  'Internet addiction has become a serious behavioral health problem in Asia .',
  'Internet addiction is a serious problem that can negatively impact both the physical and mental health of individuals .',
  'The number of internet users is increasing rapidly and internet addiction among adolescents has become a serious public health problem in Korea .',
  'Computer overuse has been a serious problem for the past several years .',
  'Widespread use of the internet is a serious concern among university students worldwide .',
  'Internet addiction is a serious problem with a profound impact on mental health .',
  'Two groups of adult video gamers were identified : those players who did ( N=37 ) and those who did not ( N=80 ) identify as having a serious gaming problem at the initial survey intake .',
  'Internet addiction ( IA ) among adolescents is a serious public health problem around the world .',
  'We aimed to examine the effectivity of a guided ICBT combined with a serious gaming intervention in improving self-reported psychophysiological and immunological health endpoints in response to psychophysiological and immune-related challenges .',
  'Internet addiction ( IA ) , also referred to as Internet use disorder , is a serious problem all over the world , especially in Asian countries .',
  'Procrastination is seen as a severe problem among young people , and many factors have been claimed to be associated with it , playing video games being one of them .',
  'The spread of these games through the internet and social networks is becoming a serious health problem facing physicians and medical professionals every day , especially in the ED ; for this reason , it is necessary to be aware of the risks represented by such behaviors in order to recognize and identify preliminary symptoms and develop useful prevention programs .',
  'Using serious games seems to be attractive in order to link between a serious purpose , which is handling a health problem and gaming .',
  'Problematic online gaming ( POG ) and problematic Internet use ( PIU ) have become a serious public mental health problem , with Internet gaming disorder ( IGD ) included in " Conditions for further study " section of DSM-5 .'],
 'gaming': ['A major drawback of existing health games is that they are not very well described and attributed with ( machine-readable , quantitative , and qualitative ) metadata such as the characterizing goal of the game , the target user group , or expected health effects well proven in scientific studies .',
  'Internet addition disorder ( IAD ) is currently becoming a serious mental health problem among Chinese adolescents .',
  'As excessive use of internet gaming has become a serious public health concern , increasing studies have revealed that impulsivity is one of the important risk factors of internet gaming disorder ( IGD ) .',
  'Problematic online game use ( POGU ) has become a serious global public health concern among adolescents .',
  'Excessive computer game playing ( ECGP ) has already become a serious social problem .',
  'The results of the study are in accordance with our previous findings on Internet use and mental health , confirming that Internet addiction is a potentially a serious public health problem .',
  'Internet addiction among college students has become a serious problem in China .',
  'Internet addiction is a serious problem , and the incidence has increased significantly in recent years .',
  'Internet addiction ( IA ) is currently becoming a serious mental health problem .',
  'Internet addiction has become a serious behavioral health problem in Asia .',
  'Internet addiction is a serious problem that can negatively impact both the physical and mental health of individuals .',
  'The number of internet users is increasing rapidly and internet addiction among adolescents has become a serious public health problem in Korea .',
  'Computer overuse has been a serious problem for the past several years .',
  'Widespread use of the internet is a serious concern among university students worldwide .',
  'Internet addiction is a serious problem with a profound impact on mental health .',
  'Two groups of adult video gamers were identified : those players who did ( N=37 ) and those who did not ( N=80 ) identify as having a serious gaming problem at the initial survey intake .',
  'Internet addiction ( IA ) among adolescents is a serious public health problem around the world .',
  'We aimed to examine the effectivity of a guided ICBT combined with a serious gaming intervention in improving self-reported psychophysiological and immunological health endpoints in response to psychophysiological and immune-related challenges .',
  'Internet addiction ( IA ) , also referred to as Internet use disorder , is a serious problem all over the world , especially in Asian countries .',
  'Procrastination is seen as a severe problem among young people , and many factors have been claimed to be associated with it , playing video games being one of them .',
  'The spread of these games through the internet and social networks is becoming a serious health problem facing physicians and medical professionals every day , especially in the ED ; for this reason , it is necessary to be aware of the risks represented by such behaviors in order to recognize and identify preliminary symptoms and develop useful prevention programs .',
  'Using serious games seems to be attractive in order to link between a serious purpose , which is handling a health problem and gaming .',
  'Problematic online gaming ( POG ) and problematic Internet use ( PIU ) have become a serious public mental health problem , with Internet gaming disorder ( IGD ) included in " Conditions for further study " section of DSM-5 .'],
 'games': ['A major drawback of existing health games is that they are not very well described and attributed with ( machine-readable , quantitative , and qualitative ) metadata such as the characterizing goal of the game , the target user group , or expected health effects well proven in scientific studies .',
  'Internet addition disorder ( IAD ) is currently becoming a serious mental health problem among Chinese adolescents .',
  'As excessive use of internet gaming has become a serious public health concern , increasing studies have revealed that impulsivity is one of the important risk factors of internet gaming disorder ( IGD ) .',
  'Problematic online game use ( POGU ) has become a serious global public health concern among adolescents .',
  'Excessive computer game playing ( ECGP ) has already become a serious social problem .',
  'The results of the study are in accordance with our previous findings on Internet use and mental health , confirming that Internet addiction is a potentially a serious public health problem .',
  'Internet addiction among college students has become a serious problem in China .',
  'Internet addiction is a serious problem , and the incidence has increased significantly in recent years .',
  'Internet addiction ( IA ) is currently becoming a serious mental health problem .',
  'Internet addiction has become a serious behavioral health problem in Asia .',
  'Internet addiction is a serious problem that can negatively impact both the physical and mental health of individuals .',
  'The number of internet users is increasing rapidly and internet addiction among adolescents has become a serious public health problem in Korea .',
  'Computer overuse has been a serious problem for the past several years .',
  'Widespread use of the internet is a serious concern among university students worldwide .',
  'Internet addiction is a serious problem with a profound impact on mental health .',
  'Two groups of adult video gamers were identified : those players who did ( N=37 ) and those who did not ( N=80 ) identify as having a serious gaming problem at the initial survey intake .',
  'Internet addiction ( IA ) among adolescents is a serious public health problem around the world .',
  'We aimed to examine the effectivity of a guided ICBT combined with a serious gaming intervention in improving self-reported psychophysiological and immunological health endpoints in response to psychophysiological and immune-related challenges .',
  'Internet addiction ( IA ) , also referred to as Internet use disorder , is a serious problem all over the world , especially in Asian countries .',
  'Procrastination is seen as a severe problem among young people , and many factors have been claimed to be associated with it , playing video games being one of them .',
  'The spread of these games through the internet and social networks is becoming a serious health problem facing physicians and medical professionals every day , especially in the ED ; for this reason , it is necessary to be aware of the risks represented by such behaviors in order to recognize and identify preliminary symptoms and develop useful prevention programs .',
  'Using serious games seems to be attractive in order to link between a serious purpose , which is handling a health problem and gaming .',
  'Problematic online gaming ( POG ) and problematic Internet use ( PIU ) have become a serious public mental health problem , with Internet gaming disorder ( IGD ) included in " Conditions for further study " section of DSM-5 .'],
 'bacterial': ['A serious drawback of DDS is the risk of favoring the selection of resistant microorganisms that can spread easily through the ICU and the hospital .',
  'Bacterial zoonoses still represent a serious medical problem .',
  'Robust detection of bacteria can significantly reduce risks of nosocomial infections , which are a serious problem even in developed countries ( 4.1 million cases each year in Europe ) .',
  'Thus , overcoming microbial infections have again become a serious clinical problem .',
  'Bacterial resistance is usually a serious problem in tertiary care hospitals .',
  'Toxic megacolon complicating pseudomembranous enterocolitis is a serious problem that carries a high morbidity and mortality rate , regardless of treatment .',
  'Xanthomonas maltophilia infection is recognized as a serious problem in association with immunosuppressive and invasive therapies , and with the use of broad-spectrum antibiotics .',
  'Bacterial infections constitute a severe problem in various areas of everyday life , causing pain and death , and adding enormous costs to healthcare worldwide .',
  'Bacterial infections have evolved as a life-threatening problem afflicting people due to the abuse of antibiotics and emergence of drug-resistant bacteria .',
  'Infections by motile , pathogenic bacteria , such as Campylobacter species , Clostridium species , Escherichia coli , Helicobacter pylori , Listeria monocytogenes , Neisseria gonorrhoeae , Pseudomonas aeruginosa , Salmonella species , Vibrio cholerae , and Yersinia species , represent a severe economic and health problem worldwide .',
  'Bacterial infections represent a serious health care problem , and all multicellular organisms have developed defense mechanisms to eliminate pathogens that enter the host via different paths including wounds .',
  'Bacterial infections remain a serious health concern , in particular causing life-threatening infections of hospitalized and immunocompromised patients .',
  'Infections caused by Gram-positive bacteria are a serious problem and is associated with high mortality .',
  'Endotoxicity originating from a dangerous debris ( i.e. , lipopolysaccharide , LPS ) of Gram-negative bacteria is a challenging clinical problem , but no drugs or therapeutic strategies that can successfully address this issue have been identified yet .',
  'Carbapenemase-producing organisms ( CPOs ) are a serious emerging problem for health care facilities worldwide .',
  'Bacterial infections are a serious health concern and are responsible for millions of illnesses and deaths each year in communities around the world .',
  'Chronic infections are a serious health care problem , and bacterial persisters have been implicated in infection reoccurrence .',
  'Host Defense Peptides ( HDPs ) have gained considerable interest due to the omnipresent threat of bacterial infection as a serious public health concern .',
  'Microbial pathogenesis is a serious health concern .',
  'Despite aggressive antibacterial control measures , C. trachomatis infections have been increasing , constituting a serious public health concern due to its morbidity and socioeconomic burden .',
  'Bacterial infection is a serious problem threatening human health .',
  'Bacterial spores are the most resistant form of life known on Earth and represent a serious problem for ( i ) bioterrorism attack , ( ii ) horizontal transmission of microbial pathogens in the community , and ( iii ) persistence in patients and in a nosocomial environment .',
  'This is a serious concern due to the fact that each of these patients dispenses up to 3500 bacilli in each cough , and may infect 10 - 15 people each year , eventually creating a public health problem .',
  'Pathogenic bacteria have become a serious socio-economic concern .',
  'Bacterial infectious diseases are currently a serious health problem , especially in patients compromised by illness or those receiving immune-suppressant drugs .',
  'The increasing emergence and spread of multiresistant microorganisms in hospital wards is a serious concern .',
  "Multiresistant hospital-acquired bacteria should be viewed as a serious public health issue rather than an individual hospital 's problem .",
  'Furthermore , systemic infection remains a serious concern in bacteria treatment .',
  'Although antibiotics represent an effective therapeutic option in the short-term , recurrent infections still remain a serious problem .',
  'Bacterial infections cause various life-threatening diseases and have become a serious public health problem due to the emergence of drug-resistant strains .',
  'Bacterial infectious disease is a serious public health concern throughout the world .',
  'Long-term survival of bacterial pathogens during persistent bacterial infections can be associated with antibiotic treatment failure and poses a serious public health problem .',
  'Despite cART , non – AIDS-defining bacterial infections are still a serious problem .',
  'Currently , hospital infection is a serious public health problem , and several factors may influence the occurrence of these infections , including the presence of insects , which are carriers of multidrug-resistant bacterial species .',
  'Bacteremia with resultant damage to multiple organ systems remains a serious problem in intensive care of human patients .',
  'Bacterial infections are a serious issue for public health and represent one of the major challenges of modern medicine .',
  'It is a serious health problem affecting millions of people each year and is the leading cause of Gram-negative bacteremia .',
  'The bacterial infections have always a serious problem to public health .',
  'Bacterial infections of various origins remain a serious medical problem , despite significant progress in fighting them .'],
 'dyes': ['First , these aminoanthraquinones are strong and persistent blue dyes and the administration of lower doses would minimize a potential cosmetic drawback of these compounds .',
  'But enzymatic washing of denim till date involved acid cellulase ( Trichoderma reesei ) and neutral cellulase ( Humicola isolens ) the use of which has a drawback of backstaining of the indigo dye on to the fabric .',
  'This report points out a serious regulatory problem regarding the management of second-hand clothes prior to sale and , more generally , of controls in street markets .',
  'In a search for new vital stains to reveal the microanatomy of nudibranch mollusks , the slow or very low solubility of many dyes in sea water posed a serious problem .',
  'Textile waste presents a serious environmental problem with only a small fraction of products from the fashion industry collected and re-used or recycled .',
  'Water pollution caused by dyes has been a serious problem affecting human health and environment .',
  'Textile industries generate large quantities of dye containing wastewater which pose a serious environmental problem .',
  'The water sources contaminated by toxic dyes would pose a serious problem for public health .',
  'In the last decade , adsorption has been used to minimize the pollution caused by dyes , which represents a serious environmental problem .',
  'Azo dyes are nonspecifically reduced under anaerobic conditions but the slow rates at which reactive azo dyes are converted presents a serious problem for the application of anaerobic technology as a first stage in the complete biodegradation of these compounds .',
  'The textile hub of Coimbatore city is facing a serious water pollution problem , both for surface water and groundwater .',
  'However , the release of coloured wastewaters represents a serious environmental problem and a public health concern .',
  'Microbial biodegradation and biodeterioration of cellulose based thickeners is a serious problem in industry .',
  'The degradation of textile effluent using microorganisms has been studied extensively , but disposal of generated biomass after dye degradation is a serious problem .',
  'Today , discharge of hazardous dyes from textile industries in water bodies like lakes , rivers and groundwater has become a serious problem , which contributes to increase their pollution levels significantly .',
  'The discharge of dye-colored wastewaters in surface water represents a serious environmental problem because it may decrease the water transparency , therefore having an effect on photosynthesis , and a public health concern because dyes and their reducing products are carcinogenic .',
  'The presence of synthetic dyes in wastewaters generated by the textile industry constitutes a serious environmental and health problem that urges the scientific community on an appropriate action .',
  'Environmental pollution by discharge of dye-containing effluents represents a serious ecological concern in many countries .',
  'The release of colored wastewater represents a serious environmental problem and public health concern .',
  'Metabolic engineering was then further applied to eliminate a byproduct of the spontaneous conversion of indoxyl to indigo , thereby solving a serious problem with the use of bio-indigo in the final denim dyeing application .',
  'Massive consumption of cotton fabrics has brought up a serious problem concerning the waste cotton fabrics ( WCFs ) disposal .',
  'The interference of industrial effluents such as dyes , surfactants , metals , polycyclic aromatic hydrocarbons , and pharmaceutical waste has become a severe global problem for human health due to their carcinogenic , mutagenic , and toxic properties .',
  'The discharge of organic dyes into the aquatic environment is a serious problem owing to the persistence of possible health risks and ecological hazards of these pollutants .',
  'Water pollution caused by the discharge of hazardous textile effluents is a serious environmental problem worldwide .',
  'The degradation of textile effluent using microorganisms has been studied extensively , but disposal of generated biomass after dye degradation is a serious problem .',
  'Leather wastes tanned with chromium are generated during the production process of leather , hence the wastes from hand crafted goods and footwear industries are a serious environmental problem .',
  'The discharge of dyes , specifically synthetic dyes , in wastewater represents a serious environmental problem and causes public health concerns .',
  'Wool , a recalcitrant waste mainly composed of keratin , constituted a serious problem for the environment and was not effectively valorized .',
  'As water is the most important source for survival for all individuals around the world , water pollution via synthetic toxic dyes and microorganisms is considered as a serious worldwide environmental problem .',
  'PRACTITIONER POINTS : The discharge of textile dye wastewater represents a serious environmental problem and public health concern .',
  'Water pollution due to release of industrial wastewater has already become a serious problem in almost every industry using dyes to color its products .',
  'Textile wastewater heavy metal pollution has become a severe environmental problem worldwide .',
  'The large amount of synthetic dyes in effluents is a serious concern to be addressed .',
  'Dye pollution in wastewater is a severe environmental problem because treating water containing dyes using conventional physical , chemical , and biological treatments is difficult .',
  'The high chroma of cellulosic ethanol production wastewater poses a serious environmental concern ; however , color-causing compounds are still not fully clear .',
  'Cotton lint trash is a serious problem in the textile industry .',
  'In the treatment of synthetic dye wastewater by photosynthetic bacteria under optical irradiation , excessive algal growth and adhesion on the wall of the reactor has been a severe problem .',
  'Experimental results indicate that the phenol under alkaline condition and aniline in all pH conditions cause a serious color problem during the period of early initial ozonation .'],
 'textile': ['First , these aminoanthraquinones are strong and persistent blue dyes and the administration of lower doses would minimize a potential cosmetic drawback of these compounds .',
  'But enzymatic washing of denim till date involved acid cellulase ( Trichoderma reesei ) and neutral cellulase ( Humicola isolens ) the use of which has a drawback of backstaining of the indigo dye on to the fabric .',
  'This report points out a serious regulatory problem regarding the management of second-hand clothes prior to sale and , more generally , of controls in street markets .',
  'In a search for new vital stains to reveal the microanatomy of nudibranch mollusks , the slow or very low solubility of many dyes in sea water posed a serious problem .',
  'Textile waste presents a serious environmental problem with only a small fraction of products from the fashion industry collected and re-used or recycled .',
  'Water pollution caused by dyes has been a serious problem affecting human health and environment .',
  'Textile industries generate large quantities of dye containing wastewater which pose a serious environmental problem .',
  'The water sources contaminated by toxic dyes would pose a serious problem for public health .',
  'In the last decade , adsorption has been used to minimize the pollution caused by dyes , which represents a serious environmental problem .',
  'Azo dyes are nonspecifically reduced under anaerobic conditions but the slow rates at which reactive azo dyes are converted presents a serious problem for the application of anaerobic technology as a first stage in the complete biodegradation of these compounds .',
  'The textile hub of Coimbatore city is facing a serious water pollution problem , both for surface water and groundwater .',
  'However , the release of coloured wastewaters represents a serious environmental problem and a public health concern .',
  'Microbial biodegradation and biodeterioration of cellulose based thickeners is a serious problem in industry .',
  'The degradation of textile effluent using microorganisms has been studied extensively , but disposal of generated biomass after dye degradation is a serious problem .',
  'Today , discharge of hazardous dyes from textile industries in water bodies like lakes , rivers and groundwater has become a serious problem , which contributes to increase their pollution levels significantly .',
  'The discharge of dye-colored wastewaters in surface water represents a serious environmental problem because it may decrease the water transparency , therefore having an effect on photosynthesis , and a public health concern because dyes and their reducing products are carcinogenic .',
  'The presence of synthetic dyes in wastewaters generated by the textile industry constitutes a serious environmental and health problem that urges the scientific community on an appropriate action .',
  'Environmental pollution by discharge of dye-containing effluents represents a serious ecological concern in many countries .',
  'The release of colored wastewater represents a serious environmental problem and public health concern .',
  'Metabolic engineering was then further applied to eliminate a byproduct of the spontaneous conversion of indoxyl to indigo , thereby solving a serious problem with the use of bio-indigo in the final denim dyeing application .',
  'Massive consumption of cotton fabrics has brought up a serious problem concerning the waste cotton fabrics ( WCFs ) disposal .',
  'The interference of industrial effluents such as dyes , surfactants , metals , polycyclic aromatic hydrocarbons , and pharmaceutical waste has become a severe global problem for human health due to their carcinogenic , mutagenic , and toxic properties .',
  'The discharge of organic dyes into the aquatic environment is a serious problem owing to the persistence of possible health risks and ecological hazards of these pollutants .',
  'Water pollution caused by the discharge of hazardous textile effluents is a serious environmental problem worldwide .',
  'The degradation of textile effluent using microorganisms has been studied extensively , but disposal of generated biomass after dye degradation is a serious problem .',
  'Leather wastes tanned with chromium are generated during the production process of leather , hence the wastes from hand crafted goods and footwear industries are a serious environmental problem .',
  'The discharge of dyes , specifically synthetic dyes , in wastewater represents a serious environmental problem and causes public health concerns .',
  'Wool , a recalcitrant waste mainly composed of keratin , constituted a serious problem for the environment and was not effectively valorized .',
  'As water is the most important source for survival for all individuals around the world , water pollution via synthetic toxic dyes and microorganisms is considered as a serious worldwide environmental problem .',
  'PRACTITIONER POINTS : The discharge of textile dye wastewater represents a serious environmental problem and public health concern .',
  'Water pollution due to release of industrial wastewater has already become a serious problem in almost every industry using dyes to color its products .',
  'Textile wastewater heavy metal pollution has become a severe environmental problem worldwide .',
  'The large amount of synthetic dyes in effluents is a serious concern to be addressed .',
  'Dye pollution in wastewater is a severe environmental problem because treating water containing dyes using conventional physical , chemical , and biological treatments is difficult .',
  'The high chroma of cellulosic ethanol production wastewater poses a serious environmental concern ; however , color-causing compounds are still not fully clear .',
  'Cotton lint trash is a serious problem in the textile industry .',
  'In the treatment of synthetic dye wastewater by photosynthetic bacteria under optical irradiation , excessive algal growth and adhesion on the wall of the reactor has been a severe problem .',
  'Experimental results indicate that the phenol under alkaline condition and aniline in all pH conditions cause a serious color problem during the period of early initial ozonation .'],
 'dye': ['First , these aminoanthraquinones are strong and persistent blue dyes and the administration of lower doses would minimize a potential cosmetic drawback of these compounds .',
  'But enzymatic washing of denim till date involved acid cellulase ( Trichoderma reesei ) and neutral cellulase ( Humicola isolens ) the use of which has a drawback of backstaining of the indigo dye on to the fabric .',
  'This report points out a serious regulatory problem regarding the management of second-hand clothes prior to sale and , more generally , of controls in street markets .',
  'In a search for new vital stains to reveal the microanatomy of nudibranch mollusks , the slow or very low solubility of many dyes in sea water posed a serious problem .',
  'Textile waste presents a serious environmental problem with only a small fraction of products from the fashion industry collected and re-used or recycled .',
  'Water pollution caused by dyes has been a serious problem affecting human health and environment .',
  'Textile industries generate large quantities of dye containing wastewater which pose a serious environmental problem .',
  'The water sources contaminated by toxic dyes would pose a serious problem for public health .',
  'In the last decade , adsorption has been used to minimize the pollution caused by dyes , which represents a serious environmental problem .',
  'Azo dyes are nonspecifically reduced under anaerobic conditions but the slow rates at which reactive azo dyes are converted presents a serious problem for the application of anaerobic technology as a first stage in the complete biodegradation of these compounds .',
  'The textile hub of Coimbatore city is facing a serious water pollution problem , both for surface water and groundwater .',
  'However , the release of coloured wastewaters represents a serious environmental problem and a public health concern .',
  'Microbial biodegradation and biodeterioration of cellulose based thickeners is a serious problem in industry .',
  'The degradation of textile effluent using microorganisms has been studied extensively , but disposal of generated biomass after dye degradation is a serious problem .',
  'Today , discharge of hazardous dyes from textile industries in water bodies like lakes , rivers and groundwater has become a serious problem , which contributes to increase their pollution levels significantly .',
  'The discharge of dye-colored wastewaters in surface water represents a serious environmental problem because it may decrease the water transparency , therefore having an effect on photosynthesis , and a public health concern because dyes and their reducing products are carcinogenic .',
  'The presence of synthetic dyes in wastewaters generated by the textile industry constitutes a serious environmental and health problem that urges the scientific community on an appropriate action .',
  'Environmental pollution by discharge of dye-containing effluents represents a serious ecological concern in many countries .',
  'The release of colored wastewater represents a serious environmental problem and public health concern .',
  'Metabolic engineering was then further applied to eliminate a byproduct of the spontaneous conversion of indoxyl to indigo , thereby solving a serious problem with the use of bio-indigo in the final denim dyeing application .',
  'Massive consumption of cotton fabrics has brought up a serious problem concerning the waste cotton fabrics ( WCFs ) disposal .',
  'The interference of industrial effluents such as dyes , surfactants , metals , polycyclic aromatic hydrocarbons , and pharmaceutical waste has become a severe global problem for human health due to their carcinogenic , mutagenic , and toxic properties .',
  'The discharge of organic dyes into the aquatic environment is a serious problem owing to the persistence of possible health risks and ecological hazards of these pollutants .',
  'Water pollution caused by the discharge of hazardous textile effluents is a serious environmental problem worldwide .',
  'The degradation of textile effluent using microorganisms has been studied extensively , but disposal of generated biomass after dye degradation is a serious problem .',
  'Leather wastes tanned with chromium are generated during the production process of leather , hence the wastes from hand crafted goods and footwear industries are a serious environmental problem .',
  'The discharge of dyes , specifically synthetic dyes , in wastewater represents a serious environmental problem and causes public health concerns .',
  'Wool , a recalcitrant waste mainly composed of keratin , constituted a serious problem for the environment and was not effectively valorized .',
  'As water is the most important source for survival for all individuals around the world , water pollution via synthetic toxic dyes and microorganisms is considered as a serious worldwide environmental problem .',
  'PRACTITIONER POINTS : The discharge of textile dye wastewater represents a serious environmental problem and public health concern .',
  'Water pollution due to release of industrial wastewater has already become a serious problem in almost every industry using dyes to color its products .',
  'Textile wastewater heavy metal pollution has become a severe environmental problem worldwide .',
  'The large amount of synthetic dyes in effluents is a serious concern to be addressed .',
  'Dye pollution in wastewater is a severe environmental problem because treating water containing dyes using conventional physical , chemical , and biological treatments is difficult .',
  'The high chroma of cellulosic ethanol production wastewater poses a serious environmental concern ; however , color-causing compounds are still not fully clear .',
  'Cotton lint trash is a serious problem in the textile industry .',
  'In the treatment of synthetic dye wastewater by photosynthetic bacteria under optical irradiation , excessive algal growth and adhesion on the wall of the reactor has been a severe problem .',
  'Experimental results indicate that the phenol under alkaline condition and aniline in all pH conditions cause a serious color problem during the period of early initial ozonation .'],
 'infectious': ["A major drawback of modern society 's rapidly increasing mobility is the ease with which dangerous infections can be imported into Europe .",
  'Infectious diseases are a serious social problem .',
  'Infectious diseases constitute a serious problem for human health and life .',
  'Infectious diseases , although a small part in the overall statistics of deaths , have not ceased to be a serious public health problem .',
  'Despite smaller numbers of deaths reported from infectious causes these diseases still represent a serious problem for Poland compared to countries in Western Europe .',
  'Infectious diseases remain a serious public health concern globally , while the need for reliable and representative surveillance systems remains as acute as ever .',
  'In many countries , the number of this type of incidents has markedly decreased , whereas in Poland blood-borne infections are still a serious problem .',
  'This raises a serious concern for public health and leaves nations with the task of determining the infectious agents that have the greatest potential to establish within their borders .',
  'In spite of some unquestionable positive tendencies observed over the last few years , occupational infectious diseases still pose a serious problem in Poland .',
  'Infectious diseases represent a serious and worldwide public health problem .',
  'The spread of viral infections remains a serious public health problem .',
  'The re-emerging diseases of the twenty-first century are a serious problem for public health and even though there has been enormous progress in medical science and in the battle against infectious diseases , they are still a long way from being really brought under control .',
  'Infectious diseases are a serious global problem , which not only take an enormous human toll but also incur tremendous economic losses .',
  'Therefore , chronically infected people should perceive it as a serious health problem and move on to appropriate health behaviour .'],
 'poland': ["A major drawback of modern society 's rapidly increasing mobility is the ease with which dangerous infections can be imported into Europe .",
  'Infectious diseases are a serious social problem .',
  'Infectious diseases constitute a serious problem for human health and life .',
  'Infectious diseases , although a small part in the overall statistics of deaths , have not ceased to be a serious public health problem .',
  'Despite smaller numbers of deaths reported from infectious causes these diseases still represent a serious problem for Poland compared to countries in Western Europe .',
  'Infectious diseases remain a serious public health concern globally , while the need for reliable and representative surveillance systems remains as acute as ever .',
  'In many countries , the number of this type of incidents has markedly decreased , whereas in Poland blood-borne infections are still a serious problem .',
  'This raises a serious concern for public health and leaves nations with the task of determining the infectious agents that have the greatest potential to establish within their borders .',
  'In spite of some unquestionable positive tendencies observed over the last few years , occupational infectious diseases still pose a serious problem in Poland .',
  'Infectious diseases represent a serious and worldwide public health problem .',
  'The spread of viral infections remains a serious public health problem .',
  'The re-emerging diseases of the twenty-first century are a serious problem for public health and even though there has been enormous progress in medical science and in the battle against infectious diseases , they are still a long way from being really brought under control .',
  'Infectious diseases are a serious global problem , which not only take an enormous human toll but also incur tremendous economic losses .',
  'Therefore , chronically infected people should perceive it as a serious health problem and move on to appropriate health behaviour .'],
 'hepatotoxicity': ['A major drawback of these nonsteroidal compounds was a strong inhibition of the hepatic drug-metabolizing enzyme CYP1A2 .',
  'A rapid decline of cytochrome P450 ( CYP450 ) enzyme activities remains a drawback of rat hepatocyte-based in vitro cultures .',
  'The β-carboline alkaloid harmine is a high affinity inhibitor of DYRK1A but suffers from the drawback of inhibiting monoamine oxidase A ( MAO-A ) with even higher potency .',
  'Drug-induced hepatotoxicity is a serious problem and has repeatedly led to the withdrawal of a drug after successful launching .',
  'Drug-induced liver injury ( DILI ) due to the use of prescription and non-prescription medication by HIV-positive and HIV-negative patients is one of the main causes of acute liver failure and transplantation in Western countries and , although rare , has to be considered a serious problem because of its unforeseeable nature and possibly fatal course .',
  'Despite growing research , drug-induced liver injury ( DILI ) remains a serious issue of increasing importance to the medical community that challenges health systems , pharmaceutical industries and drug regulatory agencies .',
  'This case illustrates how a severe metabolic alkalosis can result from a significant ingestion of Gaviscon , and that such presentations can give rise to diagnostic dilemma .',
  'Drug-induced toxicity , which impairs human organ function , is a serious problem during drug development that hinders the clinical use of many marketed drugs , and the underlying mechanisms are complicated .',
  'Drug-induced liver injury ( DILI ) is a serious problem in pre-clinical stages of drug development and clinical pharmacotherapy , but the pathogenesis of DILI has not been elucidated .',
  'Idiosyncratic drug-induced liver injury ( iDILI ) is a serious concern in drug development .',
  'In current scenario of human health and diseases , drug-induced hepatic injury has been recognized as a serious and unresolved problem .',
  'Drug-induced liver injury has become a serious health problem in contemporary society .',
  'Drug-induced liver injury has become a serious public health problem that can not be ignored .',
  'Drug-induced liver injury ( DILI ) is considered gradually as a serious public health issue , and hepatotoxicity has been regarded as the main clinical problem caused by it .',
  'Hepatic adverse drug reactions remain a serious concern for several drugs widely used in clinical practice .',
  'Acetaminophen (APAP)-induced acute liver failure ( ALF ) is a serious health problem in developed countries .',
  'Despite the treatment availability and monitoring , drug-induced hepatotoxicity ( DIH ) is a serious concern and can lead to discontinuation of treatment .',
  'Idiosyncratic drug-induced liver injury ( iDILI ) is a frequent cause of acute liver injury and a serious problem in late stage drug-development .',
  'Drug-induced liver injury ( DILI ) is a severe adverse drug reaction which is of major concern to patients , clinicians and the pharmaceutical industry .',
  'Hepatotoxicity to isoniazid is a serious problem .',
  'Drug-induced liver injury ( DILI ) is considered a serious problem related to public health , due to its unpredictability and acute response .',
  'Acetaminophen ( APAP ) hepatotoxicity is a serious public health problem in western countries .',
  'Drug-induced liver injury has become a serious public health problem .',
  'Liver toxicity is a severe problem associated with Traditional Chinese Medicine ( TCM ) .',
  'The liver performs a variety of essential functions ; hence drug-induced liver injury ( DILI ) is a serious concern that can ultimately lead to the withdrawal of a drug from the market or discontinuation of drug development .',
  'Drug-induced liver injury ( DILI ) , which is caused by drugs and herbal or dietary supplements , remains a serious concern for drug developers , regulators , and clinicians ; however , serum biomarkers utilized to detect and monitor DILI have not changed in decades and have limitations .',
  'Acetaminophen-associated liver toxicity remains a serious concern , but guidance regarding dose selection is ambiguous , and the literature describing acetaminophen efficacy and toxicity in pediatrics is limited .',
  'Drug-induced liver injury ( DILI ) is a serious concern during drug development and the treatment of human disease .',
  'Hepatotoxicity is a serious problem during drug development and for the use of many established drugs .',
  'Hepatotoxicity and acute liver failure caused by an acetaminophen overdose is a serious clinical problem in western countries .',
  'The induction of human cytochrome P450 enzymes ( CYPs ) often poses a serious problem in clinical practice .',
  'Drug-induced liver injury ( DILI ) is a serious worldwide health problem that accounts for more than 50 % of acute liver failure .',
  "Resveratrol ( 3,5,4'-trihydroxy-trans-stilbene ) is an unfulfilled promise for health care : its exploitation is hindered by rapid conjugative metabolism in enterocytes and hepatocytes ; low water solubility is a serious practical problem ."],
 'acetaminophen': ['A major drawback of these nonsteroidal compounds was a strong inhibition of the hepatic drug-metabolizing enzyme CYP1A2 .',
  'A rapid decline of cytochrome P450 ( CYP450 ) enzyme activities remains a drawback of rat hepatocyte-based in vitro cultures .',
  'The β-carboline alkaloid harmine is a high affinity inhibitor of DYRK1A but suffers from the drawback of inhibiting monoamine oxidase A ( MAO-A ) with even higher potency .',
  'Drug-induced hepatotoxicity is a serious problem and has repeatedly led to the withdrawal of a drug after successful launching .',
  'Drug-induced liver injury ( DILI ) due to the use of prescription and non-prescription medication by HIV-positive and HIV-negative patients is one of the main causes of acute liver failure and transplantation in Western countries and , although rare , has to be considered a serious problem because of its unforeseeable nature and possibly fatal course .',
  'Despite growing research , drug-induced liver injury ( DILI ) remains a serious issue of increasing importance to the medical community that challenges health systems , pharmaceutical industries and drug regulatory agencies .',
  'This case illustrates how a severe metabolic alkalosis can result from a significant ingestion of Gaviscon , and that such presentations can give rise to diagnostic dilemma .',
  'Drug-induced toxicity , which impairs human organ function , is a serious problem during drug development that hinders the clinical use of many marketed drugs , and the underlying mechanisms are complicated .',
  'Drug-induced liver injury ( DILI ) is a serious problem in pre-clinical stages of drug development and clinical pharmacotherapy , but the pathogenesis of DILI has not been elucidated .',
  'Idiosyncratic drug-induced liver injury ( iDILI ) is a serious concern in drug development .',
  'In current scenario of human health and diseases , drug-induced hepatic injury has been recognized as a serious and unresolved problem .',
  'Drug-induced liver injury has become a serious health problem in contemporary society .',
  'Drug-induced liver injury has become a serious public health problem that can not be ignored .',
  'Drug-induced liver injury ( DILI ) is considered gradually as a serious public health issue , and hepatotoxicity has been regarded as the main clinical problem caused by it .',
  'Hepatic adverse drug reactions remain a serious concern for several drugs widely used in clinical practice .',
  'Acetaminophen (APAP)-induced acute liver failure ( ALF ) is a serious health problem in developed countries .',
  'Despite the treatment availability and monitoring , drug-induced hepatotoxicity ( DIH ) is a serious concern and can lead to discontinuation of treatment .',
  'Idiosyncratic drug-induced liver injury ( iDILI ) is a frequent cause of acute liver injury and a serious problem in late stage drug-development .',
  'Drug-induced liver injury ( DILI ) is a severe adverse drug reaction which is of major concern to patients , clinicians and the pharmaceutical industry .',
  'Hepatotoxicity to isoniazid is a serious problem .',
  'Drug-induced liver injury ( DILI ) is considered a serious problem related to public health , due to its unpredictability and acute response .',
  'Acetaminophen ( APAP ) hepatotoxicity is a serious public health problem in western countries .',
  'Drug-induced liver injury has become a serious public health problem .',
  'Liver toxicity is a severe problem associated with Traditional Chinese Medicine ( TCM ) .',
  'The liver performs a variety of essential functions ; hence drug-induced liver injury ( DILI ) is a serious concern that can ultimately lead to the withdrawal of a drug from the market or discontinuation of drug development .',
  'Drug-induced liver injury ( DILI ) , which is caused by drugs and herbal or dietary supplements , remains a serious concern for drug developers , regulators , and clinicians ; however , serum biomarkers utilized to detect and monitor DILI have not changed in decades and have limitations .',
  'Acetaminophen-associated liver toxicity remains a serious concern , but guidance regarding dose selection is ambiguous , and the literature describing acetaminophen efficacy and toxicity in pediatrics is limited .',
  'Drug-induced liver injury ( DILI ) is a serious concern during drug development and the treatment of human disease .',
  'Hepatotoxicity is a serious problem during drug development and for the use of many established drugs .',
  'Hepatotoxicity and acute liver failure caused by an acetaminophen overdose is a serious clinical problem in western countries .',
  'The induction of human cytochrome P450 enzymes ( CYPs ) often poses a serious problem in clinical practice .',
  'Drug-induced liver injury ( DILI ) is a serious worldwide health problem that accounts for more than 50 % of acute liver failure .',
  "Resveratrol ( 3,5,4'-trihydroxy-trans-stilbene ) is an unfulfilled promise for health care : its exploitation is hindered by rapid conjugative metabolism in enterocytes and hepatocytes ; low water solubility is a serious practical problem ."],
 'glucocorticoid': ['However , steroid-induced bone loss constitutes a potential drawback of this treatment option .',
  'Glucocorticoid (GC)-induced osteoporosis and fractures have become a serious problem for Eastern Asians .',
  'Focal bone loss around inflamed joints in patients with autoimmune disease , such as rheumatoid arthritis , remains a serious clinical problem .',
  'These results indicated that clenbuterol induced the muscular hypertrophy but inhibited the longitudinal growth of bones in young male rats , which may be a serious concern in any ergogenic use .',
  'Among the side-effects caused by steroids , non-traumatic osteonecrosis of the femoral head ( ONF ) constitutes a serious problem .',
  'Glucocorticoids-induced osteoporosis is a serious problem for patients with systemic autoimmune disease requiring relatively long-term glucocorticoid treatment .',
  'Glucocorticoid is effective medicines for the treatment of , such as , collagen diseases , pulmonary diseases , skin diseases , organ transplantation , however , glucocorticoid induced osteoporosis have been a serious problem .',
  'Steroid-induced osteoporosis ( SIO ) is a serious complication of long-term steroid therapy and is of particular concern in growing children .',
  'Glucocorticoid-induced osteoporosis ( GIOP ) is a serious problem for patients with rheumatic diseases requiring long-term glucocorticoid treatment .',
  'Glucocorticoid (GC)-induced osteoporosis ( GIO ) is a serious problem for patients taking GC therapy .',
  'Glucocorticoid induced osteopenia is also a serious clinical problem in patients with various nonrenal diseases and can be prevented , or at least attenuated , by pamidronate and other bisphosphonates .'],
 'steroid': ['However , steroid-induced bone loss constitutes a potential drawback of this treatment option .',
  'Glucocorticoid (GC)-induced osteoporosis and fractures have become a serious problem for Eastern Asians .',
  'Focal bone loss around inflamed joints in patients with autoimmune disease , such as rheumatoid arthritis , remains a serious clinical problem .',
  'These results indicated that clenbuterol induced the muscular hypertrophy but inhibited the longitudinal growth of bones in young male rats , which may be a serious concern in any ergogenic use .',
  'Among the side-effects caused by steroids , non-traumatic osteonecrosis of the femoral head ( ONF ) constitutes a serious problem .',
  'Glucocorticoids-induced osteoporosis is a serious problem for patients with systemic autoimmune disease requiring relatively long-term glucocorticoid treatment .',
  'Glucocorticoid is effective medicines for the treatment of , such as , collagen diseases , pulmonary diseases , skin diseases , organ transplantation , however , glucocorticoid induced osteoporosis have been a serious problem .',
  'Steroid-induced osteoporosis ( SIO ) is a serious complication of long-term steroid therapy and is of particular concern in growing children .',
  'Glucocorticoid-induced osteoporosis ( GIOP ) is a serious problem for patients with rheumatic diseases requiring long-term glucocorticoid treatment .',
  'Glucocorticoid (GC)-induced osteoporosis ( GIO ) is a serious problem for patients taking GC therapy .',
  'Glucocorticoid induced osteopenia is also a serious clinical problem in patients with various nonrenal diseases and can be prevented , or at least attenuated , by pamidronate and other bisphosphonates .'],
 'prostatectomy': ['However , a major drawback of LRPE is the transperitoneal route of access to the extraperitoneal prostate .',
  'Prolonged postoperative incontinence is a major drawback of RRP .',
  'However , a major drawback of LRPE is the transperitoneal route of access to the extraperitoneal organ of the prostate .',
  'Urinary incontinence after prostatectomy or radiation is a devastating problem in men and remains the most feared complication following the treatment of localized prostate cancer .',
  'Urinary complications resulting from benign prostatic hyperplasia and bladder outlet obstruction continue to be a serious health problem .',
  'Anastomotic strictures ( AS ) are uncommon but a vexing problem after radical prostatectomy .',
  'In contrast to urinary continence , erectile dysfunction is still a serious concern for patients who undergo radical prostatectomy .',
  'While severe urinary dysfunction is rare , sexual impairment remains a serious concern after rectal resection with TME .',
  'Urinary incontinence post retropubic " anatomical " radical prostatectomy remains a distressing problem for the patient and the physician rating from 6 to 20 % even in the hands of experienced surgeons from high volume Academic Centers .',
  'Since the surgical technique does not seem to be the factor responsible for such a serious problem , more accentuated by the fact that this operation is becoming increasingly frequent with the increase in life expectancy , an assessment of 15 patients before and after prostatectomy is presented .',
  'Urinary incontinence after radical prostatectomy continues to be a distressing problem , even with preservation of the neurovascular bundles and meticulous apical dissection .'],
 'extraperitoneal': ['However , a major drawback of LRPE is the transperitoneal route of access to the extraperitoneal prostate .',
  'Prolonged postoperative incontinence is a major drawback of RRP .',
  'However , a major drawback of LRPE is the transperitoneal route of access to the extraperitoneal organ of the prostate .',
  'Urinary incontinence after prostatectomy or radiation is a devastating problem in men and remains the most feared complication following the treatment of localized prostate cancer .',
  'Urinary complications resulting from benign prostatic hyperplasia and bladder outlet obstruction continue to be a serious health problem .',
  'Anastomotic strictures ( AS ) are uncommon but a vexing problem after radical prostatectomy .',
  'In contrast to urinary continence , erectile dysfunction is still a serious concern for patients who undergo radical prostatectomy .',
  'While severe urinary dysfunction is rare , sexual impairment remains a serious concern after rectal resection with TME .',
  'Urinary incontinence post retropubic " anatomical " radical prostatectomy remains a distressing problem for the patient and the physician rating from 6 to 20 % even in the hands of experienced surgeons from high volume Academic Centers .',
  'Since the surgical technique does not seem to be the factor responsible for such a serious problem , more accentuated by the fact that this operation is becoming increasingly frequent with the increase in life expectancy , an assessment of 15 patients before and after prostatectomy is presented .',
  'Urinary incontinence after radical prostatectomy continues to be a distressing problem , even with preservation of the neurovascular bundles and meticulous apical dissection .'],
 'lrpe': ['However , a major drawback of LRPE is the transperitoneal route of access to the extraperitoneal prostate .',
  'Prolonged postoperative incontinence is a major drawback of RRP .',
  'However , a major drawback of LRPE is the transperitoneal route of access to the extraperitoneal organ of the prostate .',
  'Urinary incontinence after prostatectomy or radiation is a devastating problem in men and remains the most feared complication following the treatment of localized prostate cancer .',
  'Urinary complications resulting from benign prostatic hyperplasia and bladder outlet obstruction continue to be a serious health problem .',
  'Anastomotic strictures ( AS ) are uncommon but a vexing problem after radical prostatectomy .',
  'In contrast to urinary continence , erectile dysfunction is still a serious concern for patients who undergo radical prostatectomy .',
  'While severe urinary dysfunction is rare , sexual impairment remains a serious concern after rectal resection with TME .',
  'Urinary incontinence post retropubic " anatomical " radical prostatectomy remains a distressing problem for the patient and the physician rating from 6 to 20 % even in the hands of experienced surgeons from high volume Academic Centers .',
  'Since the surgical technique does not seem to be the factor responsible for such a serious problem , more accentuated by the fact that this operation is becoming increasingly frequent with the increase in life expectancy , an assessment of 15 patients before and after prostatectomy is presented .',
  'Urinary incontinence after radical prostatectomy continues to be a distressing problem , even with preservation of the neurovascular bundles and meticulous apical dissection .'],
 'transperitoneal': ['However , a major drawback of LRPE is the transperitoneal route of access to the extraperitoneal prostate .',
  'Prolonged postoperative incontinence is a major drawback of RRP .',
  'However , a major drawback of LRPE is the transperitoneal route of access to the extraperitoneal organ of the prostate .',
  'Urinary incontinence after prostatectomy or radiation is a devastating problem in men and remains the most feared complication following the treatment of localized prostate cancer .',
  'Urinary complications resulting from benign prostatic hyperplasia and bladder outlet obstruction continue to be a serious health problem .',
  'Anastomotic strictures ( AS ) are uncommon but a vexing problem after radical prostatectomy .',
  'In contrast to urinary continence , erectile dysfunction is still a serious concern for patients who undergo radical prostatectomy .',
  'While severe urinary dysfunction is rare , sexual impairment remains a serious concern after rectal resection with TME .',
  'Urinary incontinence post retropubic " anatomical " radical prostatectomy remains a distressing problem for the patient and the physician rating from 6 to 20 % even in the hands of experienced surgeons from high volume Academic Centers .',
  'Since the surgical technique does not seem to be the factor responsible for such a serious problem , more accentuated by the fact that this operation is becoming increasingly frequent with the increase in life expectancy , an assessment of 15 patients before and after prostatectomy is presented .',
  'Urinary incontinence after radical prostatectomy continues to be a distressing problem , even with preservation of the neurovascular bundles and meticulous apical dissection .'],
 'gvhd': ['A major drawback of cord blood has been the risk of transfusion reaction secondary to ABO incompatibility and reduction in the stem cell pool if cord blood is manipulated to remove red cells .',
  'Delayed hematopoietic recovery is a major drawback of umbilical cord blood ( UCB ) transplantation .',
  'GvHD and infections were the main contributors to a substantial transplant related morbidity and mortality , the major drawback of allogeneic stem cell transplantation .',
  'A major drawback of cord blood has been the risk of transfusion reactions in ABO blood group incompatibility and drastic reduction in the stem cell pool if the cord blood is manipulated to remove red cells prior to cryopreservation or after thawing .',
  'Tumor relapses remain a serious problem after allogeneic stem cell transplantation ( alloSCT ) , despite the long-term persistence of minor histocompatibility antigen (MiHA)-specific memory CD8(+ ) T cells specific for the tumor .',
  'A vexing problem after hematopoietic cell transplantation ( HCT ) for leukemia is assessing the biologic significance of low numbers of cells " suspicious " for relapse seen in morphologic review of peripheral blood smears ( PBSs ) .',
  'Although higher rates of engraftment failure as compared to other stem cell sources after cord blood transplantation ( CBT ) have been a serious concern , the mechanisms underlying these failures have gradually been clarified by analyzing accumulated clinical data , thereby contributing to improvement of engraftment .',
  'However , delayed engraftment , prolonged neutropenia , secondary graft loss , and graft-versus-host disease ( GVHD ) in recipients of cord blood transplantation ( CBT ) make opportunistic infections a serious concern .',
  "Although high-dose chemotherapy with autologous peripheral blood stem cell transplantation ( autoPBSCT ) has been shown or confirmed to be an effective treatment for high-risk and relapsed non-Hodgkin 's lymphoma ( NHL ) , relapse after autoPBSCT remains a serious problem .",
  'This study confirms that infectious toxicity after peripheral blood progenitor cell transplantation is usually moderate , although bacteremia remains a serious problem .',
  'Tumor relapse after human leukocyte antigen-matched allogeneic stem cell transplantation ( SCT ) remains a serious problem , despite the long-term presence of minor histocompatibility antigen (MiHA)-specific memory T cells .',
  'Acute graft-versus-host disease ( GVHD ) following allogeneic bone marrow transplantation remains a serious problem .',
  'Relapses after autologous transplantation are a serious clinical problem in patients with haematological diseases .',
  'Although the higher rate of engraftment failure remains a serious concern after cord blood transplantation ( CBT ) , the mechanisms underlying this risk have gradually been clarified , which has helped to improve engraftment .',
  'Since the advent of bone marrow transplantation , a vexing clinical problem is that of acute graft-vs-host disease ( GVHD ) .',
  'Delayed recovery of mature blood cells poses a serious , expensive , and often life-threatening problem for many stem cell transplantation recipients , particularly if heavily pretreated and serving as their own donor , or having a CB transplantation as the only therapeutic option .',
  'Severe bacterial infections are a serious problem after cord blood transplantation ( CBT ) .'],
 'hemodialysis': ['The recirculation of previously dialyzed blood in the lumen of the single-needle catheter reduces dialysis efficiency and is a drawback of single-needle dialysis .',
  'Postdialytic rebound ( PDR ) of plasma solutes is a relevant drawback of intermittent hemodialysis , but its pathophysiological process remains undefined .',
  'Postprandial hypotension during hemodialysis is a serious problem .',
  'Repeated pain during haemodialysis access cannulations is a serious problem for haemodialysis patients even when prescribed oral or topical analgesics .',
  "Degradation of dialysis efficiency during hemodialysis , caused by incompatible indwelling needle size or increase in hematocrit , is a serious problem that can threaten a patient 's life .",
  'SVCS constitutes a serious clinical problem and often represents a definitive loss of vascular access for haemodialysis ( HD ) .',
  'Vascular access dysfunction is a serious problem in dialysis units .',
  'Aluminum ( Al ) accumulation in bone is a serious problem in patients on hemodialysis .',
  'The occurrence of thrombosis in the vascular access is a serious problem that may severely compromise or even make the hemodialysis impossible , which is vital for the patient .',
  'Secondary hyperparathyroidism remains a serious problem in hemodialysis patients .',
  'However , in conjunction with disturbances in serum phosphate , Ca , and CaxP product , hyperparathyroidism has become a serious problem in the cardiovascular diseases of patients with end-stage renal disease-even patients undergoing CAPD .',
  'Vascular access thrombosis represents a serious and common problem in hemodialysis patients .',
  'Vascular access thrombosis represents a serious and unfortunately common problem in hemodialysis patients .',
  'Arteriovenous fistula puncture pain is a serious problem for patients undergoing dialysis and a good indication for topical anesthetics .',
  'Thromboembolic obstruction of the renal artery is a serious clinical problem , but rarely diagnosed .',
  'This can cause hypovolemia-induced hypotension , a serious problem in the daily practice of hemodialysis : during one out of three sessions a hypotensive episode occurs .',
  'Orthostatic hypotension is a serious problem in patients with diabetes mellitus ( DM ) undergoing hemodialysis ( HD ) .',
  'Vascular access thrombosis represents a serious problem in haemodialysis patients .'],
 'haemodialysis': ['The recirculation of previously dialyzed blood in the lumen of the single-needle catheter reduces dialysis efficiency and is a drawback of single-needle dialysis .',
  'Postdialytic rebound ( PDR ) of plasma solutes is a relevant drawback of intermittent hemodialysis , but its pathophysiological process remains undefined .',
  'Postprandial hypotension during hemodialysis is a serious problem .',
  'Repeated pain during haemodialysis access cannulations is a serious problem for haemodialysis patients even when prescribed oral or topical analgesics .',
  "Degradation of dialysis efficiency during hemodialysis , caused by incompatible indwelling needle size or increase in hematocrit , is a serious problem that can threaten a patient 's life .",
  'SVCS constitutes a serious clinical problem and often represents a definitive loss of vascular access for haemodialysis ( HD ) .',
  'Vascular access dysfunction is a serious problem in dialysis units .',
  'Aluminum ( Al ) accumulation in bone is a serious problem in patients on hemodialysis .',
  'The occurrence of thrombosis in the vascular access is a serious problem that may severely compromise or even make the hemodialysis impossible , which is vital for the patient .',
  'Secondary hyperparathyroidism remains a serious problem in hemodialysis patients .',
  'However , in conjunction with disturbances in serum phosphate , Ca , and CaxP product , hyperparathyroidism has become a serious problem in the cardiovascular diseases of patients with end-stage renal disease-even patients undergoing CAPD .',
  'Vascular access thrombosis represents a serious and common problem in hemodialysis patients .',
  'Vascular access thrombosis represents a serious and unfortunately common problem in hemodialysis patients .',
  'Arteriovenous fistula puncture pain is a serious problem for patients undergoing dialysis and a good indication for topical anesthetics .',
  'Thromboembolic obstruction of the renal artery is a serious clinical problem , but rarely diagnosed .',
  'This can cause hypovolemia-induced hypotension , a serious problem in the daily practice of hemodialysis : during one out of three sessions a hypotensive episode occurs .',
  'Orthostatic hypotension is a serious problem in patients with diabetes mellitus ( DM ) undergoing hemodialysis ( HD ) .',
  'Vascular access thrombosis represents a serious problem in haemodialysis patients .'],
 'hypotension': ['The recirculation of previously dialyzed blood in the lumen of the single-needle catheter reduces dialysis efficiency and is a drawback of single-needle dialysis .',
  'Postdialytic rebound ( PDR ) of plasma solutes is a relevant drawback of intermittent hemodialysis , but its pathophysiological process remains undefined .',
  'Postprandial hypotension during hemodialysis is a serious problem .',
  'Repeated pain during haemodialysis access cannulations is a serious problem for haemodialysis patients even when prescribed oral or topical analgesics .',
  "Degradation of dialysis efficiency during hemodialysis , caused by incompatible indwelling needle size or increase in hematocrit , is a serious problem that can threaten a patient 's life .",
  'SVCS constitutes a serious clinical problem and often represents a definitive loss of vascular access for haemodialysis ( HD ) .',
  'Vascular access dysfunction is a serious problem in dialysis units .',
  'Aluminum ( Al ) accumulation in bone is a serious problem in patients on hemodialysis .',
  'The occurrence of thrombosis in the vascular access is a serious problem that may severely compromise or even make the hemodialysis impossible , which is vital for the patient .',
  'Secondary hyperparathyroidism remains a serious problem in hemodialysis patients .',
  'However , in conjunction with disturbances in serum phosphate , Ca , and CaxP product , hyperparathyroidism has become a serious problem in the cardiovascular diseases of patients with end-stage renal disease-even patients undergoing CAPD .',
  'Vascular access thrombosis represents a serious and common problem in hemodialysis patients .',
  'Vascular access thrombosis represents a serious and unfortunately common problem in hemodialysis patients .',
  'Arteriovenous fistula puncture pain is a serious problem for patients undergoing dialysis and a good indication for topical anesthetics .',
  'Thromboembolic obstruction of the renal artery is a serious clinical problem , but rarely diagnosed .',
  'This can cause hypovolemia-induced hypotension , a serious problem in the daily practice of hemodialysis : during one out of three sessions a hypotensive episode occurs .',
  'Orthostatic hypotension is a serious problem in patients with diabetes mellitus ( DM ) undergoing hemodialysis ( HD ) .',
  'Vascular access thrombosis represents a serious problem in haemodialysis patients .'],
 'thrombosis': ['The recirculation of previously dialyzed blood in the lumen of the single-needle catheter reduces dialysis efficiency and is a drawback of single-needle dialysis .',
  'Postdialytic rebound ( PDR ) of plasma solutes is a relevant drawback of intermittent hemodialysis , but its pathophysiological process remains undefined .',
  'Pediatric hospital-acquired ( HA ) venous thromboembolism ( VTE ) is a vexing problem with improvement efforts hampered by lack of robust surveillance methods to establish accurate rates of HA-VTE .',
  'Venous thromboembolism ( VTE ) , which is characterized by pulmonary embolism and deep vein thrombosis , has become a serious public concern .',
  'Venous thromboembolism ( VTE ) and deep vein thrombophlebitis ( DVT ) is a serious problem with high mortality and morbidity rates .',
  'Venous thromboembolism ( VTE ) remains a serious problem , and treatments surrounding this potentially life-threatening disease continue to evolve .',
  'The thrombotic risk of spaceflight : has a serious problem been overlooked for more than half of a century ?',
  'Deep venous thrombosis and pulmonary embolism , together called venous thromboembolism , remain a serious national health problem .',
  'Postprandial hypotension during hemodialysis is a serious problem .',
  'Deep-vein thrombosis ( DVT ) is a serious problem that affects millions of people annually .',
  'Most of the responding surgeons consider venous thromboembolism a serious health problem .',
  'Repeated pain during haemodialysis access cannulations is a serious problem for haemodialysis patients even when prescribed oral or topical analgesics .',
  "Degradation of dialysis efficiency during hemodialysis , caused by incompatible indwelling needle size or increase in hematocrit , is a serious problem that can threaten a patient 's life .",
  'The increasing detection of VTE among Indian population , lack of awareness , underestimation of the risk , and fear of bleeding complications after chemical prophylaxis have made deep vein thrombosis ( DVT ) a serious problem , hence a standard guideline for thromboprophylaxis after trauma is essential .',
  'SVCS constitutes a serious clinical problem and often represents a definitive loss of vascular access for haemodialysis ( HD ) .',
  'Thrombus formation remains a serious problem in developing blood compatible materials .',
  'Post-deep vein thrombosis ( DVT ) venous insufficiency is a vexing problem despite effective anticoagulation , and is characterized by vein wall fibrosis .',
  'Venous thromboembolism ( VTE ) is a serious medical problem and is one of the most important preventable causes of mortality and morbidity in hospitalized patients .',
  'Deep vein thrombosis is a serious medical problem that may lead to pulmonary embolus .',
  'Cerebral venous and sinus thrombosis ( CVST ) is still considered a severe clinical problem that is difficult to diagnose and manage and is linked to a poor prognosis .',
  'Vascular access dysfunction is a serious problem in dialysis units .',
  'Deep venous thrombosis ( DVT ) is a serious problem that can potentially lead to many complications including life-threatening pulmonary arterial thrombosis .',
  'In the United States ( U.S. ) , the high morbidity and mortality rates make VTE a serious health concern ( 1 - 2 ) .',
  'Thrombosis is a serious problem in the United States .',
  'Aluminum ( Al ) accumulation in bone is a serious problem in patients on hemodialysis .',
  'The occurrence of thrombosis in the vascular access is a serious problem that may severely compromise or even make the hemodialysis impossible , which is vital for the patient .',
  'Thrombosis is a serious problem , and often leads to irreversible vision loss .',
  'Venous thromboembolism is a serious health problem and a significant cause of morbidity and mortality .',
  'Secondary hyperparathyroidism remains a serious problem in hemodialysis patients .',
  'Travel-related thrombosis is a serious public health concern considering the large and increasing number of travellers .',
  'Deep vein thrombosis ( DVT ) and its devastating complication , pulmonary embolism , are a severe health problem with high mortality .',
  'Venous thromboembolism ( VTE ) , comprising deep vein thrombosis and pulmonary embolism , is a serious clinical and public health concern .',
  'Venous thromboembolism ( VTE ) and its manifestations , including deep vein thrombosis ( DVT ) and pulmonary embolism ( PE ) , pose a life-threatening health problem for thousands of people each year .',
  'Venous thromboembolism ( VTE ) is a serious health problem for which pharmacological prophylaxis has been proven to be effective .',
  'Deep Vein Thrombosis ( DVT ) is a life threatening condition and a serious concern among hospitalised patients , with death occurring in approximately 6 % of cases .',
  'However , in conjunction with disturbances in serum phosphate , Ca , and CaxP product , hyperparathyroidism has become a serious problem in the cardiovascular diseases of patients with end-stage renal disease-even patients undergoing CAPD .',
  'Deep vein thrombosis is a severe health problem .',
  'Vascular access thrombosis represents a serious and common problem in hemodialysis patients .',
  'Vascular access thrombosis represents a serious and unfortunately common problem in hemodialysis patients .',
  'Arteriovenous fistula puncture pain is a serious problem for patients undergoing dialysis and a good indication for topical anesthetics .',
  'Thromboembolic obstruction of the renal artery is a serious clinical problem , but rarely diagnosed .',
  'This can cause hypovolemia-induced hypotension , a serious problem in the daily practice of hemodialysis : during one out of three sessions a hypotensive episode occurs .',
  'Deep vein thrombosis ( DVT ) is a serious health problem that affects more than 2 million people annually in the United States .',
  'Inappropriate thromboprophylaxis is a serious problem in Iran .',
  'Venous thromboembolism ( VTE ) prophylaxis , despite evidence for its efficacy , is not reliably and consistently prescribed , and is currently a serious concern for patient safety .',
  'Orthostatic hypotension is a serious problem in patients with diabetes mellitus ( DM ) undergoing hemodialysis ( HD ) .',
  'Vascular access thrombosis represents a serious problem in haemodialysis patients .',
  'These data reveal that DVT is a serious health problem in Spain , with high morbidity and mortality .',
  'Venous thromboembolism ( VTE ) , which includes deep vein thrombosis ( DVT ) and pulmonary embolism ( PE ) , is a serious health and social care problem of the developed world , affecting 1 in 1000 adults every year , and with an annual financial overhead of approximately £ 640 million .',
  'Deep venous thrombosis ( DVT ) remains a serious clinical problem that affects millions of people worldwide .',
  'Venous thromboembolism is a serious , potentially lethal health problem affecting one per 1,000 people annually .',
  'Venous thromboembolism in family caregivers is a rare but a serious problem .'],
 'particulate': ['Currently monitoring of PM is done on the basis of interpolating a mass of PM by volume ( μg/m(3 ) ) but has the drawback of not taking the chemical nature of PM into account .',
  'Face masks are widely used to filter airborne pollutants , especially when particulate matter ( PM ) pollution has become a serious concern to public health .',
  'Particulate matter ( PM ) pollution is a serious environmental problem in most of the cities in the Yangtze River Delta region .',
  'The particulate matter has become a serious health problem in some large cities in the world .',
  'MPs pose a serious challenge to the marine environment such as the sources and properties of MP particles , their impact on marine organisms , and the challenges of environmental pollution .',
  'Fine particulate ( PM2.5 ) is a severe problem of air pollution in the world .',
  'Pollutant particulate matter ( PM ) is a serious global problem , presenting a threat to the health and well being of human subjects .',
  'Particulate matter ( PM ) pollution is a serious concern for the environment and public health .',
  'In China , particulate pollution is a serious environmental problem that is influencing air quality , regional and global climates , and human health .',
  'Particulate pollution is currently regarded as a severe environmental problem , which is intimately linked to reductions in air quality and human health , as well as global climate change .',
  'Particle matter ( PM ) and its associated compounds are a serious problem for urban air quality and a threat to human health .',
  'Airborne particulate matter ( PM ) pollution has become a severe environmental concern calling for electret fibrous materials with high filtration efficiency and low pressure drop .',
  'In this work , PM(10 ) samples were collected in a winter and a summer in Christchurch , a New Zealand city having intensive wood and coal burning and a serious air pollution problem in winter .',
  'Particulate pollution is a serious health problem throughout the world , exacerbating a wide range of respiratory and vascular illnesses in urban areas .',
  'Particulate matter with an aerodynamic diameter < 2.5 μm ( PM2.5 ) represents a severe environmental problem and is of negative impact on human health .',
  'Ambient inhalable particulate matter ( PM ) is a serious health concern worldwide , but especially so in China where high PM concentrations affect huge populations .',
  'Particulate air pollution is becoming a serious public health concern in urban cities of China .',
  'Airborne particulate matter ( APM ) is a major air pollutant , and the effect on human health of fine APM ( PM2.5 ) deposited deep inside the lungs has recently become a serious concern .',
  'Particulate pollution has emerged as a serious environmental health concern in Pakistan .',
  'Coarse particulate matter with aerodynamic diameter between 2.5 and [ Formula : see text ] ( [ Formula : see text ] ) air pollution is a severe environmental problem in developing countries , but its challenges to public health were rarely evaluated .',
  'The rise in particulate matter ( PM ) concentrations is a serious problem for the environment .',
  'Airborne particulate matter ( PM ) pollution has become a serious environmental problem .',
  'Particulate pollution from anthropogenic and natural sources is a severe problem in China .',
  'Atmospheric Particulate matter ( PM ) with small sizes has caused a serious air-pollution problem calling for high-performance PM-capture materials and promising remediation strategies .',
  'PM in ambient air arises from industry , local heating , and vehicle emissions and poses a serious problem mainly in large cities .'],
 'air': ['Currently monitoring of PM is done on the basis of interpolating a mass of PM by volume ( μg/m(3 ) ) but has the drawback of not taking the chemical nature of PM into account .',
  'Face masks are widely used to filter airborne pollutants , especially when particulate matter ( PM ) pollution has become a serious concern to public health .',
  'Particulate matter ( PM ) pollution is a serious environmental problem in most of the cities in the Yangtze River Delta region .',
  'The particulate matter has become a serious health problem in some large cities in the world .',
  'MPs pose a serious challenge to the marine environment such as the sources and properties of MP particles , their impact on marine organisms , and the challenges of environmental pollution .',
  'Fine particulate ( PM2.5 ) is a severe problem of air pollution in the world .',
  'Pollutant particulate matter ( PM ) is a serious global problem , presenting a threat to the health and well being of human subjects .',
  'Particulate matter ( PM ) pollution is a serious concern for the environment and public health .',
  'In China , particulate pollution is a serious environmental problem that is influencing air quality , regional and global climates , and human health .',
  'Particulate pollution is currently regarded as a severe environmental problem , which is intimately linked to reductions in air quality and human health , as well as global climate change .',
  'Particle matter ( PM ) and its associated compounds are a serious problem for urban air quality and a threat to human health .',
  'Airborne particulate matter ( PM ) pollution has become a severe environmental concern calling for electret fibrous materials with high filtration efficiency and low pressure drop .',
  'In this work , PM(10 ) samples were collected in a winter and a summer in Christchurch , a New Zealand city having intensive wood and coal burning and a serious air pollution problem in winter .',
  'Particulate pollution is a serious health problem throughout the world , exacerbating a wide range of respiratory and vascular illnesses in urban areas .',
  'Particulate matter with an aerodynamic diameter < 2.5 μm ( PM2.5 ) represents a severe environmental problem and is of negative impact on human health .',
  'Ambient inhalable particulate matter ( PM ) is a serious health concern worldwide , but especially so in China where high PM concentrations affect huge populations .',
  'Particulate air pollution is becoming a serious public health concern in urban cities of China .',
  'Airborne particulate matter ( APM ) is a major air pollutant , and the effect on human health of fine APM ( PM2.5 ) deposited deep inside the lungs has recently become a serious concern .',
  'Particulate pollution has emerged as a serious environmental health concern in Pakistan .',
  'Coarse particulate matter with aerodynamic diameter between 2.5 and [ Formula : see text ] ( [ Formula : see text ] ) air pollution is a severe environmental problem in developing countries , but its challenges to public health were rarely evaluated .',
  'The rise in particulate matter ( PM ) concentrations is a serious problem for the environment .',
  'Airborne particulate matter ( PM ) pollution has become a serious environmental problem .',
  'Particulate pollution from anthropogenic and natural sources is a severe problem in China .',
  'Atmospheric Particulate matter ( PM ) with small sizes has caused a serious air-pollution problem calling for high-performance PM-capture materials and promising remediation strategies .',
  'PM in ambient air arises from industry , local heating , and vehicle emissions and poses a serious problem mainly in large cities .'],
 'aureus': ['A serious drawback of this strain , however , is its ineffectiveness against Gram-positive strains , such as the human pathogen Staphylococcus aureus .',
  'A major drawback of mecA PCR to detect methicillin-resistant Staphylococcus aureus ( MRSA ) directly from patient materials is the high frequency of methicillin-resistant coagulase-negative staphylococci .',
  'Staphylococcus epidermidis is a normal commensal of skin that has become a serious clinical problem because of the combination of increased use of intravascular devices and an increasing number of hospitalized immunocompromised patients .',
  '[ Methicillin-resistant Staphylococcus aureus : a serious problem for the patient ] .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) has recently become a serious problem in various fields of medicine .',
  'Staphylococcus aureus has become a serious concern in hospitals and community due to rapid adaptation to existing antimicrobial agents .',
  'MRSA bacteraemia is now a serious problem in children in England and Wales .',
  'The growing emergency of infections with community-acquired methicillin-resistant Staphylococcus aureus ( CA-MRSA ) secreting the Panton-Valentine toxin ( PVL ) has become a serious health problem with epidemic proportions .',
  'Staphylococcus aureus is a frequent cause of infections , and antibiotic-resistant S. aureus has become a serious problem .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) poses a serious therapeutic problem worldwide , and its frequency in most African countries has not been reported .',
  'Ampicillin-resistant S. aureus ( ARSA ) now poses a serious problem for hospitalized patients , and their care providers .',
  'In the last decades , MRSA started as a serious problem only in hospitals , but in recent years it also rose as an alarming community pathogen .',
  'In the present study , we evaluated the clinical diagnosis and treatment of cutaneous anthrax , a rare disease that nonetheless remains a serious healthcare problem in developing countries .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) , that have acquired multiresistance to all classes of antibiotics , have become a serious nosocomial problem .',
  'Vancomycin has been the drug of choice for the treatment of multiresistant MRSA infections in the last three decades , but the management of invasive MRSA infections will become a serious problem if VISA strains become widespread .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) infections are a serious global problem , with considerable impact on patients and substantial health care costs .',
  'As with S. aureus , coagulase-negative staphylococci ( CNS ) represent a serious concern in hospital-acquired infections .',
  'Methicillin resistant Staphylococcus aureus ( MRSA ) constitute a serious health care problem worldwide .',
  'Identification of methicillin-resistant Staphylococcus aureus by drug-susceptibility tests alone poses a serious problem , because a considerable number of clinical S. aureus isolates are borderline resistant to methicillin .',
  'The high prevalence of CA-MRSA carriage in the population could pose a serious public health concern for the region .',
  'The predominance of constitutive erythromycin resistance is a serious problem and limits the use of clindamycin for severe staphylococcal infections not only in this university hospital , but in many countries worldwide .',
  'Staphylococcus aureus is an important cause of food intoxication , whereas methicillin-resistant S. aureus ( MRSA ) constitutes a serious public-health concern due to its ability to colonize and infect humans and animals .',
  'PRACTICAL APPLICATIONS : Methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious concern in hospitals because of its known antibiotic resistance .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) strains are a major cause of hospital-acquired infections and are considered a serious public health concern .',
  'Bacterial resistance to antibiotics is a serious global problem and includes strains of beta-lactam-resistant Staphylococcus aureus and methicillin-resistant S. aureus ( MRSA ) .',
  'MRSA remains a serious problem because of the high incidence and multidrug resistance of the strains , even for strains isolated from foods , food environments and food handlers .',
  'Nosocomial infections caused by methicillin-resistant staphylococci ( MRSA ) pose a serious problem in many countries .',
  'This report demonstrates that family members can serve as reservoirs of CA-MRSA which may become a serious problem in containing the spread of MRSA .',
  'The widespread emergence of methicillin resistant Staphylococcus aureus , as a common cause of nosocomial infections , is becoming a serious concern in global public health .',
  'Increasing levels of antibiotic resistance in pathogens , including Staphylococcus aureus , remains a serious problem for public health , leading to the need for better alternative antimicrobial strategies .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) continues to be a serious human pathogen , and particularly the spread of community associated (CA)-MRSA strains such as USA300 is a concern , as these strains can cause severe infections in otherwise healthy adults .',
  'Infection by methicillin-resistant Staphylococcus aureus ( MRSA ) presents a serious problem , as these organisms are resistant to a wide range of antibiotics .',
  'Methicillin-resistant Staphylococcus aureus infection is a serious clinical problem worldwide .',
  'Community-associated methicillin resistant Staphylococcus aureus ( CA-MRSA ) has become a severe health concern because of its treatment difficulties .',
  'Nosocomial infections involving epidemic methicillin-resistant Staphylococcus aureus ( MRSA ) strains are a serious problem in many countries .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) commonly causes refractory infections and has recently become a serious public health concern .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) has become a serious problem in intensive care units , because of development of multiresistance , and also intrinsic resistance to beta-lactam antibiotics .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) infection is a serious clinical problem worldwide .',
  'An increasing prevalence of methicillin-resistant Staphylococcus aureus ( MRSA ) has created a serious therapeutic problem .',
  'In Japan , most strains of MRSA now represent high level resistance to all antibiotics , except for a few antibiotics , such as vancomycin and arbekacin , and therefore , they posed a serious problem clinically and epidemiologically , via immuno-suppressed inpatients , in particular , as the causative pathogen of nosocomial infection .',
  'The understanding and control of infections caused by staphylococci are still far from complete , and staphylococcal infections continue to be a serious problem .',
  'Multidrug-resistance of methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious therapeutical problem .',
  'Although severe infection caused by methicillin-resistant Staphylococcus aureus ( MRSA ) has become a serious social problem in medical facilities , it is relatively uncommon in the urological field .',
  'Infections caused by hard-to-treat methicillin-resistant Staphylococcus aureus ( MRSA ) are a serious global public-health concern , as MRSA has become broadly resistant to many classes of antibiotics .',
  'Nosocomial infections due to staphylococci continue to pose a serious health concern worldwide .',
  'Methicillin-resistant Staphylococcus aureus-related infections have become a serious problem worldwide .',
  'Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment , especially methicillin-resistant S. aureus ( MRSA ) .',
  'Staphylococcus aureus harboured by Panton-Valentine leukocidin ( PVL ) is emerging as a serious problem worldwide .',
  'The presence of methicillin-resistant Staphylococcus aureus ( MRSA ) in hospitals and the community is a serious problem .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) is a life-threatening pathogen in humans and its presence in animals is a public health concern .',
  '\ufeffStaphylococcus aureus continues to be a serious health problem worldwide due to its intrinsic nature of virulence , ability to cause a wide array of infection , and its capacity to develop resistance to a number of antibiotics .',
  'Currently , coagulase negative staphylococci ( CoNS ) have got much attention as a serious health problem especially in neonates and children .',
  '[ Robert Koch Institute : Multiresistant staphylococci -- a serious problem in hospital health ] .',
  'The emergence of these infections is a serious therapeutic problem , since vancomycine is a major antibiotic used in the treatment of meticillin-resistant S. aureus ( MRSA ) infections .',
  'The frequent importation of PVL-positive CA-MRSA into healthcare settings , transmission and association with outbreaks is a serious ongoing concern .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) has emerged as a serious problem in the community .',
  'MRSA is a serious clinical and epidemiologic problem .',
  'The results indicate that MRSHo with high antibiotic resistance and unknown SCCmec might become a serious problem in the future for the treatment of patients such as children .',
  'The investigation of methicillin resistance in Staphylococcus aureus ( MRSA ) is a serious problem for the physician and microbiologist .',
  'Emergence of drug resistant strains especially methicillin resistant S. aureus ( MRSA ) is a serious problem in hospital environment .',
  'Staphylococcus aureus is a human pathogen rapidly becoming a serious health problem due to ease of acquiring antibiotic resistance .',
  'Very low birthweight or premature infants had become the targets of MRSA infection and this has now become a serious problem .',
  'This result suggests a serious problem may be encountered in treatment of staphylococcal infections in Jordan .',
  'Staphylococcus aureus , particularly methicillin-resistant S.aureus ( MRSA ) , is a life-threatening pathogen in humans , and its presence in food is a public health concern .',
  'The high resistance acquired by MRSA needs a serious concern and efforts should be carried out for the discovery of better therapeutics .',
  'Appearance of MRSA strains in the community is becoming a serious public health problem .',
  'The global spread of methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious problem , particularly in mainland China .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) is spreading worldwide and poses a serious public health problem , being present in hospital settings and communities .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) isolates is a serious public health problem whose ever-increasing rate is commensurate with the pressure it is exerting on the healthcare system .',
  'The prevalence of community-acquired meticillin-resistant Staphylococcus aureus ( CA-MRSA ) strains has become a serious problem worldwide .',
  'Therefore , MRSA strains have become a serious problem in the clinical setting .',
  'MRSA infection poses a serious problem for physicians and their patients .',
  "Infections with methicillin-resistant Staphylococcus aureus ( MRSA ) and methicillin-resistant coagulase-negative Staphylococcus ( MR-CNS ) are a serious problem in hospitals because these bacteria produce penicillin-binding protein 2 ' ( PBP2 ' or PBP2a ) , which shows low affinity to β-lactam antibiotics .",
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) has been a serious problem as its infection is associated with higher mortality and increase cost worldwide .',
  'The results indicate that MRSC with high antibiotic resistance and unknown SCCmec might become a serious problem in the future for the treatment of patients particularly children .',
  'The presence and dissemination of community-associated MRSA containing vanA could become a serious public health concern .',
  'Detection of methicillin-resistant Staphylococcus aureus ( MRSA ) isolates represents a serious problem to low and media level microbiology labs .',
  'Recent studies indicated increase in the resistance of S. aureus to different antibiotics , which is a serious problem in the treatment of infections resulting from S. aureus in this region .',
  'Bacterial contamination of surfaces with methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious problem in the hospital environment and is responsible for significant nosocomial infections .',
  'Staphylococcus aureus bacteremia ( SAB ) is a serious and growing problem .',
  'Community-associated methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious public health concern and in Australia , one that disproportionately affects Aboriginal people .',
  'Infections caused by methicillin-resistant Staphylococcus aureus pose a serious problem postoperatively .',
  'Methicillin resistance in Staphylococcus aureus and in coagulase-negative staphylococci represents a serious problem both for the microbiologist and the physician .',
  'Staphylococcus epidermidis strains isolated from nosocomial infections represent a serious problem worldwide .',
  'Methicillin-Resistant Staphylococcus aureus ( MRSA ) , which is resistant to many antibiotics , creates a serious problem for human health if present in food .',
  'Staphylococcus aureus is a major human pathogen , causing community and hospital-acquired infections , and is a serious healthcare concern due to the increasing prevalence of multiple antibiotic resistances amongst clinical isolates .',
  'Emergence of daptomycin-nonsusceptible ( DNS ) Staphylococcus aureus is a dreadful problem in the treatment of endocarditis .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious nosocomial problem , globally distributed .',
  'The emergence of methicillin-resistant S. pseudintermedius ( MRSP ) is also becoming a serious concern .',
  'The emergence and rapid transmission of multidrug-resistant S. aureus strains have become a serious health concern , and highlight the challenges associated with the development of a vaccine to combat S. aureus pneumonia .',
  'The presence of nosocomial MRSA is a serious medical problem which requires continued attention to care in the overuse of antibiotics and indwelling devices in hospitals .',
  'The increasing prevalence of community-acquired MRSA and its emerging antibiotic resistance in foods is a serious problem for public health .',
  'Methicillin-resistant strains of Staphylococcus aureus ( MRSA ) constitute a serious diagnostic and therapeutic problem .',
  'Community-acquired methicillin-resistant Staphylococcus aureus ( CA-MRSA ) may represent a serious public health problem , owing to the spread of toxin-producing lineages .',
  'Due mainly to indiscriminate abuse of antibiotics , the methicillin-resistant strain known by its initials as MRSA is the most extended nosocomial infection globally and is a severe community and hospital healthcare problem .',
  'Infections caused by clinical methicillin-resistant Staphylococcus aureus ( MRSA ) are a serious public problem .',
  'Methicillin-Resistant Staphylococcus Aureus ( MRSA ) has been widely recognized as a serious problem in hospital settings .',
  'Methicillin-resistant staphylococcus aureus ( MRSA ) bacteremia is a life-threatening illness and a major global health care problem .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) poses a serious problem in some geographic areas .',
  'Staphylococcus aureus is the most common cause of skin and soft tissue infections , and rapidly emerging antibiotic-resistant strains are creating a serious public health concern .',
  'Antimicrobial resistance of methicillin-resistant Staphylococcus aureus ( MRSA ) poses a serious problem for clinicians worldwide .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) isolates are a serious public health problem whose ever-increasing rate is commensurate with the pressure it is exerting on the healthcare system .',
  'In recent years , disease caused by antibiotic-resistant S. aureus is a serious clinical problem that poses a great threat to public health .',
  'In common with coagulase-negative staphylococci , they present a serious therapeutic problem because they are often resistant to multiple antibiotics .',
  'It is concluded that the emergence of methicillin and gentamicin-tobramycin resistance among hospital staphylococci represents a serious , persistent problem .',
  "Everybody agrees that infection control is a serious problem and that something needs to be done about it , but nobody can agree exactly what . In this week 's special report , we look at NHS plans to improve the worst MRSA record in Europe .",
  'Conclusions : S. aureus in ENT departments to be a serious therapeutic and epidemiologic problem .',
  'Antibiotic resistance is a serious problem in Staphylococcus epidermidis infections as many clinical isolates of this organism are resistant to up to eight different antibiotics .',
  'This adaptation of S. aureus isolates looks to be a worrisome problem and should be carefully monitored .',
  'Infections with MRSA strains that are resistant to beta-lactams and other types of antibiotics are a serious therapeutic problem - first , because in such cases only a limited spectrum of antibiotics can be used ; and second , because such infections require prolonged hospitalization and result in economic losses .',
  'Misidentification of nosocomial S. aureus as MRSA is a serious problem in Libyan hospitals .',
  'Methicillin-resistant Staphylococcus remains a severe public health problem worldwide .',
  'Nosocomial methicillin-resistant Staphylococcus aureus ( MRSA ) infection in infants has become a serious concern and a new means of preventing the transmission of MRSA in the community needs to be considered .',
  'Device associated infections caused by Staphylococcus aureus in hospitalised patients is a serious healthcare problem .',
  'Emergence of drug resistant strains especially methicillin resistant Staphylococcus aureus is a serious problem in hospital environments .',
  'Staphylococcus aureus bacteremia is still a serious problem , and the optimal treatment is under debate .',
  'Staphylococcus aureus is a serious current health care concern .',
  'Drug-resistant staphylococci constitute a serious problem that urgently requires the discovery of new therapeutic agents .',
  'Multiple antibiotics resistance is becoming a serious problem in the management of Staph . aureus infections .',
  'Staphylococcus aureus ( Sa ) is a serious concern due to increasing resistance to antibiotics .',
  'Meticillin-resistant Staphylococcus aureus ( MRSA ) is a major pathogen responsible for significant numbers of healthcare-associated infections and isolates containing Panton-Valentine leukocidin ( PVL ) that cause severe skin infections are emerging as a serious problem .',
  'Today , significant increase in the prevalence and emergence of methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious public health concern and is likely to have a dramatic negative impact on many current medical practices .',
  'The presence of MRSA in the in-patients is a serious problem as it can act as reservoir to cause outbreak of colonisation and infection .',
  'An increasing prevalence of methicillin-resistant Staphylococcus ( S. ) aureus ( MRSA ) has a serious therapeutic problem , and accurate methods to detect such strains are needed .',
  'The increasing number of coagulase-negative staphylococci ( CNS ) causing mastitis and of bacteria resistant to conventional antibiotics has become a serious problem in recent years .'],
 'staphylococcus': ['A serious drawback of this strain , however , is its ineffectiveness against Gram-positive strains , such as the human pathogen Staphylococcus aureus .',
  'A major drawback of mecA PCR to detect methicillin-resistant Staphylococcus aureus ( MRSA ) directly from patient materials is the high frequency of methicillin-resistant coagulase-negative staphylococci .',
  'Staphylococcus epidermidis is a normal commensal of skin that has become a serious clinical problem because of the combination of increased use of intravascular devices and an increasing number of hospitalized immunocompromised patients .',
  '[ Methicillin-resistant Staphylococcus aureus : a serious problem for the patient ] .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) has recently become a serious problem in various fields of medicine .',
  'Staphylococcus aureus has become a serious concern in hospitals and community due to rapid adaptation to existing antimicrobial agents .',
  'MRSA bacteraemia is now a serious problem in children in England and Wales .',
  'The growing emergency of infections with community-acquired methicillin-resistant Staphylococcus aureus ( CA-MRSA ) secreting the Panton-Valentine toxin ( PVL ) has become a serious health problem with epidemic proportions .',
  'Staphylococcus aureus is a frequent cause of infections , and antibiotic-resistant S. aureus has become a serious problem .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) poses a serious therapeutic problem worldwide , and its frequency in most African countries has not been reported .',
  'Ampicillin-resistant S. aureus ( ARSA ) now poses a serious problem for hospitalized patients , and their care providers .',
  'In the last decades , MRSA started as a serious problem only in hospitals , but in recent years it also rose as an alarming community pathogen .',
  'In the present study , we evaluated the clinical diagnosis and treatment of cutaneous anthrax , a rare disease that nonetheless remains a serious healthcare problem in developing countries .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) , that have acquired multiresistance to all classes of antibiotics , have become a serious nosocomial problem .',
  'Vancomycin has been the drug of choice for the treatment of multiresistant MRSA infections in the last three decades , but the management of invasive MRSA infections will become a serious problem if VISA strains become widespread .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) infections are a serious global problem , with considerable impact on patients and substantial health care costs .',
  'As with S. aureus , coagulase-negative staphylococci ( CNS ) represent a serious concern in hospital-acquired infections .',
  'Methicillin resistant Staphylococcus aureus ( MRSA ) constitute a serious health care problem worldwide .',
  'Identification of methicillin-resistant Staphylococcus aureus by drug-susceptibility tests alone poses a serious problem , because a considerable number of clinical S. aureus isolates are borderline resistant to methicillin .',
  'The high prevalence of CA-MRSA carriage in the population could pose a serious public health concern for the region .',
  'The predominance of constitutive erythromycin resistance is a serious problem and limits the use of clindamycin for severe staphylococcal infections not only in this university hospital , but in many countries worldwide .',
  'Staphylococcus aureus is an important cause of food intoxication , whereas methicillin-resistant S. aureus ( MRSA ) constitutes a serious public-health concern due to its ability to colonize and infect humans and animals .',
  'PRACTICAL APPLICATIONS : Methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious concern in hospitals because of its known antibiotic resistance .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) strains are a major cause of hospital-acquired infections and are considered a serious public health concern .',
  'Bacterial resistance to antibiotics is a serious global problem and includes strains of beta-lactam-resistant Staphylococcus aureus and methicillin-resistant S. aureus ( MRSA ) .',
  'MRSA remains a serious problem because of the high incidence and multidrug resistance of the strains , even for strains isolated from foods , food environments and food handlers .',
  'Nosocomial infections caused by methicillin-resistant staphylococci ( MRSA ) pose a serious problem in many countries .',
  'This report demonstrates that family members can serve as reservoirs of CA-MRSA which may become a serious problem in containing the spread of MRSA .',
  'The widespread emergence of methicillin resistant Staphylococcus aureus , as a common cause of nosocomial infections , is becoming a serious concern in global public health .',
  'Increasing levels of antibiotic resistance in pathogens , including Staphylococcus aureus , remains a serious problem for public health , leading to the need for better alternative antimicrobial strategies .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) continues to be a serious human pathogen , and particularly the spread of community associated (CA)-MRSA strains such as USA300 is a concern , as these strains can cause severe infections in otherwise healthy adults .',
  'Infection by methicillin-resistant Staphylococcus aureus ( MRSA ) presents a serious problem , as these organisms are resistant to a wide range of antibiotics .',
  'Methicillin-resistant Staphylococcus aureus infection is a serious clinical problem worldwide .',
  'Community-associated methicillin resistant Staphylococcus aureus ( CA-MRSA ) has become a severe health concern because of its treatment difficulties .',
  'Nosocomial infections involving epidemic methicillin-resistant Staphylococcus aureus ( MRSA ) strains are a serious problem in many countries .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) commonly causes refractory infections and has recently become a serious public health concern .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) has become a serious problem in intensive care units , because of development of multiresistance , and also intrinsic resistance to beta-lactam antibiotics .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) infection is a serious clinical problem worldwide .',
  'An increasing prevalence of methicillin-resistant Staphylococcus aureus ( MRSA ) has created a serious therapeutic problem .',
  'In Japan , most strains of MRSA now represent high level resistance to all antibiotics , except for a few antibiotics , such as vancomycin and arbekacin , and therefore , they posed a serious problem clinically and epidemiologically , via immuno-suppressed inpatients , in particular , as the causative pathogen of nosocomial infection .',
  'The understanding and control of infections caused by staphylococci are still far from complete , and staphylococcal infections continue to be a serious problem .',
  'Multidrug-resistance of methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious therapeutical problem .',
  'Although severe infection caused by methicillin-resistant Staphylococcus aureus ( MRSA ) has become a serious social problem in medical facilities , it is relatively uncommon in the urological field .',
  'Infections caused by hard-to-treat methicillin-resistant Staphylococcus aureus ( MRSA ) are a serious global public-health concern , as MRSA has become broadly resistant to many classes of antibiotics .',
  'Nosocomial infections due to staphylococci continue to pose a serious health concern worldwide .',
  'Methicillin-resistant Staphylococcus aureus-related infections have become a serious problem worldwide .',
  'Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment , especially methicillin-resistant S. aureus ( MRSA ) .',
  'Staphylococcus aureus harboured by Panton-Valentine leukocidin ( PVL ) is emerging as a serious problem worldwide .',
  'The presence of methicillin-resistant Staphylococcus aureus ( MRSA ) in hospitals and the community is a serious problem .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) is a life-threatening pathogen in humans and its presence in animals is a public health concern .',
  '\ufeffStaphylococcus aureus continues to be a serious health problem worldwide due to its intrinsic nature of virulence , ability to cause a wide array of infection , and its capacity to develop resistance to a number of antibiotics .',
  'Currently , coagulase negative staphylococci ( CoNS ) have got much attention as a serious health problem especially in neonates and children .',
  '[ Robert Koch Institute : Multiresistant staphylococci -- a serious problem in hospital health ] .',
  'The emergence of these infections is a serious therapeutic problem , since vancomycine is a major antibiotic used in the treatment of meticillin-resistant S. aureus ( MRSA ) infections .',
  'The frequent importation of PVL-positive CA-MRSA into healthcare settings , transmission and association with outbreaks is a serious ongoing concern .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) has emerged as a serious problem in the community .',
  'MRSA is a serious clinical and epidemiologic problem .',
  'The results indicate that MRSHo with high antibiotic resistance and unknown SCCmec might become a serious problem in the future for the treatment of patients such as children .',
  'The investigation of methicillin resistance in Staphylococcus aureus ( MRSA ) is a serious problem for the physician and microbiologist .',
  'Emergence of drug resistant strains especially methicillin resistant S. aureus ( MRSA ) is a serious problem in hospital environment .',
  'Staphylococcus aureus is a human pathogen rapidly becoming a serious health problem due to ease of acquiring antibiotic resistance .',
  'Very low birthweight or premature infants had become the targets of MRSA infection and this has now become a serious problem .',
  'This result suggests a serious problem may be encountered in treatment of staphylococcal infections in Jordan .',
  'Staphylococcus aureus , particularly methicillin-resistant S.aureus ( MRSA ) , is a life-threatening pathogen in humans , and its presence in food is a public health concern .',
  'The high resistance acquired by MRSA needs a serious concern and efforts should be carried out for the discovery of better therapeutics .',
  'Appearance of MRSA strains in the community is becoming a serious public health problem .',
  'The global spread of methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious problem , particularly in mainland China .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) is spreading worldwide and poses a serious public health problem , being present in hospital settings and communities .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) isolates is a serious public health problem whose ever-increasing rate is commensurate with the pressure it is exerting on the healthcare system .',
  'The prevalence of community-acquired meticillin-resistant Staphylococcus aureus ( CA-MRSA ) strains has become a serious problem worldwide .',
  'Therefore , MRSA strains have become a serious problem in the clinical setting .',
  'MRSA infection poses a serious problem for physicians and their patients .',
  "Infections with methicillin-resistant Staphylococcus aureus ( MRSA ) and methicillin-resistant coagulase-negative Staphylococcus ( MR-CNS ) are a serious problem in hospitals because these bacteria produce penicillin-binding protein 2 ' ( PBP2 ' or PBP2a ) , which shows low affinity to β-lactam antibiotics .",
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) has been a serious problem as its infection is associated with higher mortality and increase cost worldwide .',
  'The results indicate that MRSC with high antibiotic resistance and unknown SCCmec might become a serious problem in the future for the treatment of patients particularly children .',
  'The presence and dissemination of community-associated MRSA containing vanA could become a serious public health concern .',
  'Detection of methicillin-resistant Staphylococcus aureus ( MRSA ) isolates represents a serious problem to low and media level microbiology labs .',
  'Recent studies indicated increase in the resistance of S. aureus to different antibiotics , which is a serious problem in the treatment of infections resulting from S. aureus in this region .',
  'Bacterial contamination of surfaces with methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious problem in the hospital environment and is responsible for significant nosocomial infections .',
  'Staphylococcus aureus bacteremia ( SAB ) is a serious and growing problem .',
  'Community-associated methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious public health concern and in Australia , one that disproportionately affects Aboriginal people .',
  'Infections caused by methicillin-resistant Staphylococcus aureus pose a serious problem postoperatively .',
  'Methicillin resistance in Staphylococcus aureus and in coagulase-negative staphylococci represents a serious problem both for the microbiologist and the physician .',
  'Staphylococcus epidermidis strains isolated from nosocomial infections represent a serious problem worldwide .',
  'Methicillin-Resistant Staphylococcus aureus ( MRSA ) , which is resistant to many antibiotics , creates a serious problem for human health if present in food .',
  'Staphylococcus aureus is a major human pathogen , causing community and hospital-acquired infections , and is a serious healthcare concern due to the increasing prevalence of multiple antibiotic resistances amongst clinical isolates .',
  'Emergence of daptomycin-nonsusceptible ( DNS ) Staphylococcus aureus is a dreadful problem in the treatment of endocarditis .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious nosocomial problem , globally distributed .',
  'The emergence of methicillin-resistant S. pseudintermedius ( MRSP ) is also becoming a serious concern .',
  'The emergence and rapid transmission of multidrug-resistant S. aureus strains have become a serious health concern , and highlight the challenges associated with the development of a vaccine to combat S. aureus pneumonia .',
  'The presence of nosocomial MRSA is a serious medical problem which requires continued attention to care in the overuse of antibiotics and indwelling devices in hospitals .',
  'The increasing prevalence of community-acquired MRSA and its emerging antibiotic resistance in foods is a serious problem for public health .',
  'Methicillin-resistant strains of Staphylococcus aureus ( MRSA ) constitute a serious diagnostic and therapeutic problem .',
  'Community-acquired methicillin-resistant Staphylococcus aureus ( CA-MRSA ) may represent a serious public health problem , owing to the spread of toxin-producing lineages .',
  'Due mainly to indiscriminate abuse of antibiotics , the methicillin-resistant strain known by its initials as MRSA is the most extended nosocomial infection globally and is a severe community and hospital healthcare problem .',
  'Infections caused by clinical methicillin-resistant Staphylococcus aureus ( MRSA ) are a serious public problem .',
  'Methicillin-Resistant Staphylococcus Aureus ( MRSA ) has been widely recognized as a serious problem in hospital settings .',
  'Methicillin-resistant staphylococcus aureus ( MRSA ) bacteremia is a life-threatening illness and a major global health care problem .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) poses a serious problem in some geographic areas .',
  'Staphylococcus aureus is the most common cause of skin and soft tissue infections , and rapidly emerging antibiotic-resistant strains are creating a serious public health concern .',
  'Antimicrobial resistance of methicillin-resistant Staphylococcus aureus ( MRSA ) poses a serious problem for clinicians worldwide .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) isolates are a serious public health problem whose ever-increasing rate is commensurate with the pressure it is exerting on the healthcare system .',
  'In recent years , disease caused by antibiotic-resistant S. aureus is a serious clinical problem that poses a great threat to public health .',
  'In common with coagulase-negative staphylococci , they present a serious therapeutic problem because they are often resistant to multiple antibiotics .',
  'It is concluded that the emergence of methicillin and gentamicin-tobramycin resistance among hospital staphylococci represents a serious , persistent problem .',
  "Everybody agrees that infection control is a serious problem and that something needs to be done about it , but nobody can agree exactly what . In this week 's special report , we look at NHS plans to improve the worst MRSA record in Europe .",
  'Conclusions : S. aureus in ENT departments to be a serious therapeutic and epidemiologic problem .',
  'Antibiotic resistance is a serious problem in Staphylococcus epidermidis infections as many clinical isolates of this organism are resistant to up to eight different antibiotics .',
  'This adaptation of S. aureus isolates looks to be a worrisome problem and should be carefully monitored .',
  'Infections with MRSA strains that are resistant to beta-lactams and other types of antibiotics are a serious therapeutic problem - first , because in such cases only a limited spectrum of antibiotics can be used ; and second , because such infections require prolonged hospitalization and result in economic losses .',
  'Misidentification of nosocomial S. aureus as MRSA is a serious problem in Libyan hospitals .',
  'Methicillin-resistant Staphylococcus remains a severe public health problem worldwide .',
  'Nosocomial methicillin-resistant Staphylococcus aureus ( MRSA ) infection in infants has become a serious concern and a new means of preventing the transmission of MRSA in the community needs to be considered .',
  'Device associated infections caused by Staphylococcus aureus in hospitalised patients is a serious healthcare problem .',
  'Emergence of drug resistant strains especially methicillin resistant Staphylococcus aureus is a serious problem in hospital environments .',
  'Staphylococcus aureus bacteremia is still a serious problem , and the optimal treatment is under debate .',
  'Staphylococcus aureus is a serious current health care concern .',
  'Drug-resistant staphylococci constitute a serious problem that urgently requires the discovery of new therapeutic agents .',
  'Multiple antibiotics resistance is becoming a serious problem in the management of Staph . aureus infections .',
  'Staphylococcus aureus ( Sa ) is a serious concern due to increasing resistance to antibiotics .',
  'Meticillin-resistant Staphylococcus aureus ( MRSA ) is a major pathogen responsible for significant numbers of healthcare-associated infections and isolates containing Panton-Valentine leukocidin ( PVL ) that cause severe skin infections are emerging as a serious problem .',
  'Today , significant increase in the prevalence and emergence of methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious public health concern and is likely to have a dramatic negative impact on many current medical practices .',
  'The presence of MRSA in the in-patients is a serious problem as it can act as reservoir to cause outbreak of colonisation and infection .',
  'An increasing prevalence of methicillin-resistant Staphylococcus ( S. ) aureus ( MRSA ) has a serious therapeutic problem , and accurate methods to detect such strains are needed .',
  'The increasing number of coagulase-negative staphylococci ( CNS ) causing mastitis and of bacteria resistant to conventional antibiotics has become a serious problem in recent years .'],
 'staphylococci': ['A serious drawback of this strain , however , is its ineffectiveness against Gram-positive strains , such as the human pathogen Staphylococcus aureus .',
  'Staphylococcus epidermidis is a normal commensal of skin that has become a serious clinical problem because of the combination of increased use of intravascular devices and an increasing number of hospitalized immunocompromised patients .',
  'Staphylococcus aureus has become a serious concern in hospitals and community due to rapid adaptation to existing antimicrobial agents .',
  'Staphylococcus aureus is a frequent cause of infections , and antibiotic-resistant S. aureus has become a serious problem .',
  'Ampicillin-resistant S. aureus ( ARSA ) now poses a serious problem for hospitalized patients , and their care providers .',
  'In the present study , we evaluated the clinical diagnosis and treatment of cutaneous anthrax , a rare disease that nonetheless remains a serious healthcare problem in developing countries .',
  'As with S. aureus , coagulase-negative staphylococci ( CNS ) represent a serious concern in hospital-acquired infections .',
  'The predominance of constitutive erythromycin resistance is a serious problem and limits the use of clindamycin for severe staphylococcal infections not only in this university hospital , but in many countries worldwide .',
  'Increasing levels of antibiotic resistance in pathogens , including Staphylococcus aureus , remains a serious problem for public health , leading to the need for better alternative antimicrobial strategies .',
  'The understanding and control of infections caused by staphylococci are still far from complete , and staphylococcal infections continue to be a serious problem .',
  'Nosocomial infections due to staphylococci continue to pose a serious health concern worldwide .',
  '\ufeffStaphylococcus aureus continues to be a serious health problem worldwide due to its intrinsic nature of virulence , ability to cause a wide array of infection , and its capacity to develop resistance to a number of antibiotics .',
  'Currently , coagulase negative staphylococci ( CoNS ) have got much attention as a serious health problem especially in neonates and children .',
  '[ Robert Koch Institute : Multiresistant staphylococci -- a serious problem in hospital health ] .',
  'Staphylococcus aureus is a human pathogen rapidly becoming a serious health problem due to ease of acquiring antibiotic resistance .',
  'This result suggests a serious problem may be encountered in treatment of staphylococcal infections in Jordan .',
  'Recent studies indicated increase in the resistance of S. aureus to different antibiotics , which is a serious problem in the treatment of infections resulting from S. aureus in this region .',
  'Staphylococcus aureus bacteremia ( SAB ) is a serious and growing problem .',
  'Staphylococcus epidermidis strains isolated from nosocomial infections represent a serious problem worldwide .',
  'Staphylococcus aureus is a major human pathogen , causing community and hospital-acquired infections , and is a serious healthcare concern due to the increasing prevalence of multiple antibiotic resistances amongst clinical isolates .',
  'Emergence of daptomycin-nonsusceptible ( DNS ) Staphylococcus aureus is a dreadful problem in the treatment of endocarditis .',
  'The emergence and rapid transmission of multidrug-resistant S. aureus strains have become a serious health concern , and highlight the challenges associated with the development of a vaccine to combat S. aureus pneumonia .',
  'Staphylococcus aureus is the most common cause of skin and soft tissue infections , and rapidly emerging antibiotic-resistant strains are creating a serious public health concern .',
  'In recent years , disease caused by antibiotic-resistant S. aureus is a serious clinical problem that poses a great threat to public health .',
  'In common with coagulase-negative staphylococci , they present a serious therapeutic problem because they are often resistant to multiple antibiotics .',
  'Conclusions : S. aureus in ENT departments to be a serious therapeutic and epidemiologic problem .',
  'Antibiotic resistance is a serious problem in Staphylococcus epidermidis infections as many clinical isolates of this organism are resistant to up to eight different antibiotics .',
  'This adaptation of S. aureus isolates looks to be a worrisome problem and should be carefully monitored .',
  'Device associated infections caused by Staphylococcus aureus in hospitalised patients is a serious healthcare problem .',
  'Staphylococcus aureus bacteremia is still a serious problem , and the optimal treatment is under debate .',
  'Staphylococcus aureus is a serious current health care concern .',
  'Drug-resistant staphylococci constitute a serious problem that urgently requires the discovery of new therapeutic agents .',
  'Multiple antibiotics resistance is becoming a serious problem in the management of Staph . aureus infections .',
  'Staphylococcus aureus ( Sa ) is a serious concern due to increasing resistance to antibiotics .',
  'The increasing number of coagulase-negative staphylococci ( CNS ) causing mastitis and of bacteria resistant to conventional antibiotics has become a serious problem in recent years .'],
 'vancomycin': ['To maintain the effectiveness of a locally delivered antibiotic without the drawback of a second surgery , we propose a hydrogel drug delivery system in which the drug release rate of vancomycin and degradation rate of the hydrogel are linked via covalent incorporation of vancomycin in the hydrogel backbone .',
  'Facilitating vancomycin-resistant enterococci colonization and/or infection is a potential drawback of both drugs .',
  'Ampicillin resistance in Enterococcus faecium is a serious concern worldwide , complicating the treatment of E. faecium infections .',
  'The emergence and expansion of VREfm CC17 with limited antibiotic options in our hospital present a serious public health menace and represent challenges to infection control .',
  'The detection of vancomycin-resistant-enterococci ( VRE ) among wild animals represents a worrisome public health concern .',
  'The isolation of enterococci that are resistant to clinically relevant antibiotics , such as erythromycin , is of a serious concern given the role enterococci play in the transfer of antibiotic resistance genes .',
  'The emerging threat of widespread vancomycin resistance poses a serious public health concern given the fact that vancomycin has long been the preferred treatment of antibiotic-resistant gram-positive organisms .',
  'Multiple-drug-resistant enterococcal infections canbe a serious problem in pediatric patients particularly concomitance with severe underlying diseases and lead to significant morbidity and mortality .',
  'The increasing frequency of Enterococcus faecium isolates with multidrug resistance is a serious clinical problem given the severely limited number of therapeutic options available to treat these infections .',
  'Infections due to vancomycin resistant enterococci ( VRE ) constitute a serious therapeutic problem in some cases .',
  'We conclude that the combination of vancomycin , ticarcillin , and amikacin is more effective than ticarcillin-clavulanate and amikacin as empirical antibiotic therapy in clinical settings in which gram-positive bacteremias are a serious problem .',
  'The emergence of glycopeptide resistance in enterococci results in a severe clinical problem .',
  'Vancomycin-resistant Enterococcus faecium is increasingly recognized as a serious problem by hospital epidemiologists .',
  'Outbreaks of vancomycin-resistant enterococcus ( VRE ) are a serious problem in hospitals .',
  'The emergence of multidrug-resistant enterococci ( MDRE ) and particularly vancomycin-resistant enterococci ( VRE ) is considered a serious health problem worldwide , causing the need for new antimicrobials .',
  "Resistance to glycopeptides in enterococci , which first emerged in the late 1980 's and is now widespread mainly in the United States , is posing a serious clinical problem due to the lack of alternative and efficacious therapeutic options , particularly against infections caused by VanA strains that are highly resistant to glycopeptides and almost all other antibiotics .",
  'The vancomycin-resistant Enterococci ( VRE ) have progressively become a severe medical problem .',
  'Development of high-level gentamicin resistance among enterococci represents a serious therapeutic problem as it precludes synergy between aminoglycosides and cell-wall active agents .',
  'Vancomycin-resistant Enterococci ( VRE ) is a serious concern for public health .',
  'As major causes of hospital-acquired infections , antibiotic-resistant enterococci are a serious public health concern .',
  'In Korea , the proportion of VRE among all enterococcal of VRE is no longer low in some settings and recent observations of a sudden increase of VRE isolation in several hospitals in Korea suggests that VRE infection may become a serious problem in the near future .',
  'Recently , vancomycin-resistant enterococci ( VRE ) such as E. faecalis and E. faecium have caused a serious problem of hospital-acquired infections in Europe and the USA .',
  'Emergence of vancomycin resistance among CNS is a serious public health concern , because CNS usually are multidrug-resistant , and glycopeptide antibiotics , among which only vancomycin is available in the United States , are the only remaining effective therapy .',
  'Colonization with multidrug-resistant vancomycin-resistant-enterococci ( VRE ) could become a serious problem , since there is no proven therapy in case of an infection or in case of transfer of glycopeptid-resistance to other organisms .',
  'Enterococci have become a vexing problem in clinical medicine because of their ability to infect patients who are typically receiving antibiotic therapy for unrelated underlying illness .',
  'Vancomycin-resistant enterococci ( VRE ) are a serious problem all over the world .',
  "Transfer of aac(6')-aph(2″ ) transposons mediating high-level gentamicin resistance ( HLGR ) in Enterococcus faecalis is a serious problem in the clinic .",
  'A three-drug antibiotic regimen including vancomycin and amikacin has been recommended as effective treatment in clinical settings in which Gram-positive bacteremias are a serious problem .',
  'The clinical development of nonsusceptibility to the lipopeptide antibiotic daptomycin remains a serious concern during therapy for infections caused by vancomycin-resistant'],
 'enterococci': ['To maintain the effectiveness of a locally delivered antibiotic without the drawback of a second surgery , we propose a hydrogel drug delivery system in which the drug release rate of vancomycin and degradation rate of the hydrogel are linked via covalent incorporation of vancomycin in the hydrogel backbone .',
  'Facilitating vancomycin-resistant enterococci colonization and/or infection is a potential drawback of both drugs .',
  'Ampicillin resistance in Enterococcus faecium is a serious concern worldwide , complicating the treatment of E. faecium infections .',
  'The emergence and expansion of VREfm CC17 with limited antibiotic options in our hospital present a serious public health menace and represent challenges to infection control .',
  'The detection of vancomycin-resistant-enterococci ( VRE ) among wild animals represents a worrisome public health concern .',
  'The isolation of enterococci that are resistant to clinically relevant antibiotics , such as erythromycin , is of a serious concern given the role enterococci play in the transfer of antibiotic resistance genes .',
  'The emerging threat of widespread vancomycin resistance poses a serious public health concern given the fact that vancomycin has long been the preferred treatment of antibiotic-resistant gram-positive organisms .',
  'Multiple-drug-resistant enterococcal infections canbe a serious problem in pediatric patients particularly concomitance with severe underlying diseases and lead to significant morbidity and mortality .',
  'The increasing frequency of Enterococcus faecium isolates with multidrug resistance is a serious clinical problem given the severely limited number of therapeutic options available to treat these infections .',
  'Infections due to vancomycin resistant enterococci ( VRE ) constitute a serious therapeutic problem in some cases .',
  'We conclude that the combination of vancomycin , ticarcillin , and amikacin is more effective than ticarcillin-clavulanate and amikacin as empirical antibiotic therapy in clinical settings in which gram-positive bacteremias are a serious problem .',
  'The emergence of glycopeptide resistance in enterococci results in a severe clinical problem .',
  'Vancomycin-resistant Enterococcus faecium is increasingly recognized as a serious problem by hospital epidemiologists .',
  'Outbreaks of vancomycin-resistant enterococcus ( VRE ) are a serious problem in hospitals .',
  'The emergence of multidrug-resistant enterococci ( MDRE ) and particularly vancomycin-resistant enterococci ( VRE ) is considered a serious health problem worldwide , causing the need for new antimicrobials .',
  "Resistance to glycopeptides in enterococci , which first emerged in the late 1980 's and is now widespread mainly in the United States , is posing a serious clinical problem due to the lack of alternative and efficacious therapeutic options , particularly against infections caused by VanA strains that are highly resistant to glycopeptides and almost all other antibiotics .",
  'The vancomycin-resistant Enterococci ( VRE ) have progressively become a severe medical problem .',
  'Development of high-level gentamicin resistance among enterococci represents a serious therapeutic problem as it precludes synergy between aminoglycosides and cell-wall active agents .',
  'Vancomycin-resistant Enterococci ( VRE ) is a serious concern for public health .',
  'As major causes of hospital-acquired infections , antibiotic-resistant enterococci are a serious public health concern .',
  'In Korea , the proportion of VRE among all enterococcal of VRE is no longer low in some settings and recent observations of a sudden increase of VRE isolation in several hospitals in Korea suggests that VRE infection may become a serious problem in the near future .',
  'Recently , vancomycin-resistant enterococci ( VRE ) such as E. faecalis and E. faecium have caused a serious problem of hospital-acquired infections in Europe and the USA .',
  'Emergence of vancomycin resistance among CNS is a serious public health concern , because CNS usually are multidrug-resistant , and glycopeptide antibiotics , among which only vancomycin is available in the United States , are the only remaining effective therapy .',
  'Colonization with multidrug-resistant vancomycin-resistant-enterococci ( VRE ) could become a serious problem , since there is no proven therapy in case of an infection or in case of transfer of glycopeptid-resistance to other organisms .',
  'Enterococci have become a vexing problem in clinical medicine because of their ability to infect patients who are typically receiving antibiotic therapy for unrelated underlying illness .',
  'Vancomycin-resistant enterococci ( VRE ) are a serious problem all over the world .',
  "Transfer of aac(6')-aph(2″ ) transposons mediating high-level gentamicin resistance ( HLGR ) in Enterococcus faecalis is a serious problem in the clinic .",
  'A three-drug antibiotic regimen including vancomycin and amikacin has been recommended as effective treatment in clinical settings in which Gram-positive bacteremias are a serious problem .',
  'The clinical development of nonsusceptibility to the lipopeptide antibiotic daptomycin remains a serious concern during therapy for infections caused by vancomycin-resistant'],
 'faecium': ['To maintain the effectiveness of a locally delivered antibiotic without the drawback of a second surgery , we propose a hydrogel drug delivery system in which the drug release rate of vancomycin and degradation rate of the hydrogel are linked via covalent incorporation of vancomycin in the hydrogel backbone .',
  'Facilitating vancomycin-resistant enterococci colonization and/or infection is a potential drawback of both drugs .',
  'Ampicillin resistance in Enterococcus faecium is a serious concern worldwide , complicating the treatment of E. faecium infections .',
  'The emergence and expansion of VREfm CC17 with limited antibiotic options in our hospital present a serious public health menace and represent challenges to infection control .',
  'The detection of vancomycin-resistant-enterococci ( VRE ) among wild animals represents a worrisome public health concern .',
  'The isolation of enterococci that are resistant to clinically relevant antibiotics , such as erythromycin , is of a serious concern given the role enterococci play in the transfer of antibiotic resistance genes .',
  'The emerging threat of widespread vancomycin resistance poses a serious public health concern given the fact that vancomycin has long been the preferred treatment of antibiotic-resistant gram-positive organisms .',
  'Multiple-drug-resistant enterococcal infections canbe a serious problem in pediatric patients particularly concomitance with severe underlying diseases and lead to significant morbidity and mortality .',
  'The increasing frequency of Enterococcus faecium isolates with multidrug resistance is a serious clinical problem given the severely limited number of therapeutic options available to treat these infections .',
  'Infections due to vancomycin resistant enterococci ( VRE ) constitute a serious therapeutic problem in some cases .',
  'We conclude that the combination of vancomycin , ticarcillin , and amikacin is more effective than ticarcillin-clavulanate and amikacin as empirical antibiotic therapy in clinical settings in which gram-positive bacteremias are a serious problem .',
  'The emergence of glycopeptide resistance in enterococci results in a severe clinical problem .',
  'Vancomycin-resistant Enterococcus faecium is increasingly recognized as a serious problem by hospital epidemiologists .',
  'Outbreaks of vancomycin-resistant enterococcus ( VRE ) are a serious problem in hospitals .',
  'The emergence of multidrug-resistant enterococci ( MDRE ) and particularly vancomycin-resistant enterococci ( VRE ) is considered a serious health problem worldwide , causing the need for new antimicrobials .',
  "Resistance to glycopeptides in enterococci , which first emerged in the late 1980 's and is now widespread mainly in the United States , is posing a serious clinical problem due to the lack of alternative and efficacious therapeutic options , particularly against infections caused by VanA strains that are highly resistant to glycopeptides and almost all other antibiotics .",
  'The vancomycin-resistant Enterococci ( VRE ) have progressively become a severe medical problem .',
  'Development of high-level gentamicin resistance among enterococci represents a serious therapeutic problem as it precludes synergy between aminoglycosides and cell-wall active agents .',
  'Vancomycin-resistant Enterococci ( VRE ) is a serious concern for public health .',
  'As major causes of hospital-acquired infections , antibiotic-resistant enterococci are a serious public health concern .',
  'In Korea , the proportion of VRE among all enterococcal of VRE is no longer low in some settings and recent observations of a sudden increase of VRE isolation in several hospitals in Korea suggests that VRE infection may become a serious problem in the near future .',
  'Recently , vancomycin-resistant enterococci ( VRE ) such as E. faecalis and E. faecium have caused a serious problem of hospital-acquired infections in Europe and the USA .',
  'Emergence of vancomycin resistance among CNS is a serious public health concern , because CNS usually are multidrug-resistant , and glycopeptide antibiotics , among which only vancomycin is available in the United States , are the only remaining effective therapy .',
  'Colonization with multidrug-resistant vancomycin-resistant-enterococci ( VRE ) could become a serious problem , since there is no proven therapy in case of an infection or in case of transfer of glycopeptid-resistance to other organisms .',
  'Enterococci have become a vexing problem in clinical medicine because of their ability to infect patients who are typically receiving antibiotic therapy for unrelated underlying illness .',
  'Vancomycin-resistant enterococci ( VRE ) are a serious problem all over the world .',
  "Transfer of aac(6')-aph(2″ ) transposons mediating high-level gentamicin resistance ( HLGR ) in Enterococcus faecalis is a serious problem in the clinic .",
  'A three-drug antibiotic regimen including vancomycin and amikacin has been recommended as effective treatment in clinical settings in which Gram-positive bacteremias are a serious problem .',
  'The clinical development of nonsusceptibility to the lipopeptide antibiotic daptomycin remains a serious concern during therapy for infections caused by vancomycin-resistant'],
 'enterococcus': ['To maintain the effectiveness of a locally delivered antibiotic without the drawback of a second surgery , we propose a hydrogel drug delivery system in which the drug release rate of vancomycin and degradation rate of the hydrogel are linked via covalent incorporation of vancomycin in the hydrogel backbone .',
  'Facilitating vancomycin-resistant enterococci colonization and/or infection is a potential drawback of both drugs .',
  'Ampicillin resistance in Enterococcus faecium is a serious concern worldwide , complicating the treatment of E. faecium infections .',
  'The emergence and expansion of VREfm CC17 with limited antibiotic options in our hospital present a serious public health menace and represent challenges to infection control .',
  'The detection of vancomycin-resistant-enterococci ( VRE ) among wild animals represents a worrisome public health concern .',
  'The isolation of enterococci that are resistant to clinically relevant antibiotics , such as erythromycin , is of a serious concern given the role enterococci play in the transfer of antibiotic resistance genes .',
  'The emerging threat of widespread vancomycin resistance poses a serious public health concern given the fact that vancomycin has long been the preferred treatment of antibiotic-resistant gram-positive organisms .',
  'Multiple-drug-resistant enterococcal infections canbe a serious problem in pediatric patients particularly concomitance with severe underlying diseases and lead to significant morbidity and mortality .',
  'The increasing frequency of Enterococcus faecium isolates with multidrug resistance is a serious clinical problem given the severely limited number of therapeutic options available to treat these infections .',
  'Infections due to vancomycin resistant enterococci ( VRE ) constitute a serious therapeutic problem in some cases .',
  'We conclude that the combination of vancomycin , ticarcillin , and amikacin is more effective than ticarcillin-clavulanate and amikacin as empirical antibiotic therapy in clinical settings in which gram-positive bacteremias are a serious problem .',
  'The emergence of glycopeptide resistance in enterococci results in a severe clinical problem .',
  'Vancomycin-resistant Enterococcus faecium is increasingly recognized as a serious problem by hospital epidemiologists .',
  'Outbreaks of vancomycin-resistant enterococcus ( VRE ) are a serious problem in hospitals .',
  'The emergence of multidrug-resistant enterococci ( MDRE ) and particularly vancomycin-resistant enterococci ( VRE ) is considered a serious health problem worldwide , causing the need for new antimicrobials .',
  "Resistance to glycopeptides in enterococci , which first emerged in the late 1980 's and is now widespread mainly in the United States , is posing a serious clinical problem due to the lack of alternative and efficacious therapeutic options , particularly against infections caused by VanA strains that are highly resistant to glycopeptides and almost all other antibiotics .",
  'The vancomycin-resistant Enterococci ( VRE ) have progressively become a severe medical problem .',
  'Development of high-level gentamicin resistance among enterococci represents a serious therapeutic problem as it precludes synergy between aminoglycosides and cell-wall active agents .',
  'Vancomycin-resistant Enterococci ( VRE ) is a serious concern for public health .',
  'As major causes of hospital-acquired infections , antibiotic-resistant enterococci are a serious public health concern .',
  'In Korea , the proportion of VRE among all enterococcal of VRE is no longer low in some settings and recent observations of a sudden increase of VRE isolation in several hospitals in Korea suggests that VRE infection may become a serious problem in the near future .',
  'Recently , vancomycin-resistant enterococci ( VRE ) such as E. faecalis and E. faecium have caused a serious problem of hospital-acquired infections in Europe and the USA .',
  'Emergence of vancomycin resistance among CNS is a serious public health concern , because CNS usually are multidrug-resistant , and glycopeptide antibiotics , among which only vancomycin is available in the United States , are the only remaining effective therapy .',
  'Colonization with multidrug-resistant vancomycin-resistant-enterococci ( VRE ) could become a serious problem , since there is no proven therapy in case of an infection or in case of transfer of glycopeptid-resistance to other organisms .',
  'Enterococci have become a vexing problem in clinical medicine because of their ability to infect patients who are typically receiving antibiotic therapy for unrelated underlying illness .',
  'Vancomycin-resistant enterococci ( VRE ) are a serious problem all over the world .',
  "Transfer of aac(6')-aph(2″ ) transposons mediating high-level gentamicin resistance ( HLGR ) in Enterococcus faecalis is a serious problem in the clinic .",
  'A three-drug antibiotic regimen including vancomycin and amikacin has been recommended as effective treatment in clinical settings in which Gram-positive bacteremias are a serious problem .',
  'The clinical development of nonsusceptibility to the lipopeptide antibiotic daptomycin remains a serious concern during therapy for infections caused by vancomycin-resistant'],
 'interactions': ['However , a notable drawback of a binary representation of interaction data is that missing endpoints for non-interacting drug-target pairs are not differentiated from inactive cases , and that predicted levels of activity depend on pre-defined binarization thresholds .',
  'On the contrary , PXR activation also imposes a serious concern for drug-drug interactions ( DDIs ) .',
  'A serious problem in everyday clinical practice is the co-administration of drugs using the same infusion line .',
  'Drug-Drug Interaction ( DDI ) is a serious concern in cardiac patients due to polypharmacy .',
  'Drug interactions ( DIs ) constitute a serious problem and are considered to contribute to 6 - 30 % of all adverse events ( AEs ) .',
  'In fact , drug interactions constitute a serious problem for current oncology primarily resulting from a narrow therapeutic index specific for the majority of anticancer drugs .',
  'The occurrence of drug-drug-interactions ( DDI ) from multiple drug dispensations is a serious problem , both for individuals and health-care systems , since patients with complications due to DDI are likely to reenter the system at a costlier level .',
  'The number of potentially relevant drug interactions represents a severe problem in drug prescribing .',
  'Potential drug-disease interactions affecting patients with COVID-19 and comorbid cardiovascular diseases are also becoming a serious concern .',
  'Drug-drug interactions ( DDIs ) present a serious , ever increasing clinical problem .',
  'However , a serious concern is the potential appearance of clinically significant drug⁻herb interactions in patients .',
  'Ideally , each of the major symptom domains associated with DLB ( behavioral , motor , and cognitive ) would be treated , but drug interactions in these patients are a serious concern .'],
 'ddi': ['However , a notable drawback of a binary representation of interaction data is that missing endpoints for non-interacting drug-target pairs are not differentiated from inactive cases , and that predicted levels of activity depend on pre-defined binarization thresholds .',
  'On the contrary , PXR activation also imposes a serious concern for drug-drug interactions ( DDIs ) .',
  'A serious problem in everyday clinical practice is the co-administration of drugs using the same infusion line .',
  'Drug-Drug Interaction ( DDI ) is a serious concern in cardiac patients due to polypharmacy .',
  'Drug interactions ( DIs ) constitute a serious problem and are considered to contribute to 6 - 30 % of all adverse events ( AEs ) .',
  'In fact , drug interactions constitute a serious problem for current oncology primarily resulting from a narrow therapeutic index specific for the majority of anticancer drugs .',
  'The occurrence of drug-drug-interactions ( DDI ) from multiple drug dispensations is a serious problem , both for individuals and health-care systems , since patients with complications due to DDI are likely to reenter the system at a costlier level .',
  'The number of potentially relevant drug interactions represents a severe problem in drug prescribing .',
  'Potential drug-disease interactions affecting patients with COVID-19 and comorbid cardiovascular diseases are also becoming a serious concern .',
  'Drug-drug interactions ( DDIs ) present a serious , ever increasing clinical problem .',
  'However , a serious concern is the potential appearance of clinically significant drug⁻herb interactions in patients .',
  'Ideally , each of the major symptom domains associated with DLB ( behavioral , motor , and cognitive ) would be treated , but drug interactions in these patients are a serious concern .'],
 'ddis': ['However , a notable drawback of a binary representation of interaction data is that missing endpoints for non-interacting drug-target pairs are not differentiated from inactive cases , and that predicted levels of activity depend on pre-defined binarization thresholds .',
  'On the contrary , PXR activation also imposes a serious concern for drug-drug interactions ( DDIs ) .',
  'A serious problem in everyday clinical practice is the co-administration of drugs using the same infusion line .',
  'Drug-Drug Interaction ( DDI ) is a serious concern in cardiac patients due to polypharmacy .',
  'Drug interactions ( DIs ) constitute a serious problem and are considered to contribute to 6 - 30 % of all adverse events ( AEs ) .',
  'In fact , drug interactions constitute a serious problem for current oncology primarily resulting from a narrow therapeutic index specific for the majority of anticancer drugs .',
  'The occurrence of drug-drug-interactions ( DDI ) from multiple drug dispensations is a serious problem , both for individuals and health-care systems , since patients with complications due to DDI are likely to reenter the system at a costlier level .',
  'The number of potentially relevant drug interactions represents a severe problem in drug prescribing .',
  'Potential drug-disease interactions affecting patients with COVID-19 and comorbid cardiovascular diseases are also becoming a serious concern .',
  'Drug-drug interactions ( DDIs ) present a serious , ever increasing clinical problem .',
  'However , a serious concern is the potential appearance of clinically significant drug⁻herb interactions in patients .',
  'Ideally , each of the major symptom domains associated with DLB ( behavioral , motor , and cognitive ) would be treated , but drug interactions in these patients are a serious concern .'],
 'nosocomial': ['Currently , blood culture is the gold standard for confirming a suspected BSI , but has the drawback of lengthy time-to-detection ( TTD ) required for indicating the presence of microbes .',
  'The ever increasing number of legal claims and lawsuits associated with nosocomial infections has become a serious problem .',
  'With the emergence of nosocomial infections as a serious problem among US hospitals , the Center for Disease Control undertook in 1974 a nationwide study to evaluate approaches to infection control .',
  'Nosocomial infections ( NI ) are a serious health problem resulting in an enromous burden of excess morbidity and mortaliti rates , and health care costs .',
  'This nosocomial infection therefore represents a serious problem , especially in developing countries where health funding and health facilities are limited .',
  "OBJECTIVE : Considering that the nosocomial infections have been a serious problem of public health all over the world in both developed and developing countries , this revision has the aim of amplifying the pediatrician 's knowledge , in different interfaces of the question .",
  'Nosocomial infections represent a serious public health problem .',
  'Possible nosocomial transmission of blood-borne pathogens is a serious concern for health care workers and patients alike .',
  'Nosocomial infection is a serious problem of morbidity and mortality that , according to the 2003 national prevalence data affected 6,5 - 7 % of all the patients admitted in Spanish hospitals .',
  'Nosocomial infections in this hospital is a serious health problem ; it is necessary to focus our medical work in this regard for the prevention and control of NI .',
  'Bacteremia is one of the most common nosocomial infections and is still a severe condition that frequently represents a life-threatening problem for the patient .',
  'Nosocomial VRE infections have become a serious problem in immuno-compromised patients throughout the world , and many VREs have been isolated in Japan in the last few years ; however , fortunately , nosocomial outbreaks are still rare .',
  'Nosocomial infections caused by multiresistant Gram-positive cocci are a serious problem for public health systems worldwide .',
  'Nosocomial bloodstream infections ( BSI ) create a serious health problem in hospitals all over the world .',
  'Nosocomial infection is a serious health and financial problem .',
  'Nosocomial infections are a serious problem for every hospital for medical and economic reasons .',
  'The nationwide prevalence study showed that nosocomial infection is a serious health problem that requires urgent intervention .',
  'Nosocomial infection ( i.e. infection in healthcare facilities ) raises a serious public health problem , as implied by the existence of pathogens characteristic to healthcare facilities such as methicillin-resistant Staphylococcus aureus and hospital-mediated outbreaks of influenza and severe acute respiratory syndrome .',
  'Nosocomial infections are a serious problem in treatment because they are caused by bacteria that have developed increased antibiotic resistance .',
  'Nosocomial infections remain a serious public health problem with serious consequences .',
  'Nosocomial infections ( NIs ) are a serious health problem in hospitals worldwide and are followed by a series of consequences , medical , judicial , ethical and economic .',
  'Nosocomial infection via the hospital environment is a serious problem , and highly touched surfaces are the main route of transmission .',
  'Nosocomial infection is regarded as a serious problem whose incidence and complexity has been increasing , thus generating various types of social and economic implications .',
  'Nosocomial or hospital acquired infection has been recognized as a serious public health problem in the last twenty years .',
  'Nosocomial infections are a serious problem in health care facilities .'],
 'malaria': ['This result reveals a possible drawback of the development of anti-malarial vaccines , especially considering the wide endemic areas for both parasitoses .',
  'Over-diagnosis and over-treatment of malaria is increasingly being recognized as a serious concern in malaria endemic regions .',
  'Malaria around the China-Myanmar border is a serious health problem in the countries of South-East Asia .',
  'Malaria remains a serious public health problem in Brazil despite a significant drop in the number of cases in the past decade .',
  'Malaria and other arthropod born diseases remain a serious public health problem affecting the lives and health of certain social groups when the two basic strategies to control fail due to : ( 1 ) the lack of effective chemoprophylaxis/chemotherapy or the rapid development of drug resistance of the infectious agents and ( 2 ) the ineffectiveness of pesticides or the arthropod vectors develop resistance to them .',
  'Since the sixties , the emergence of malarial parasites resistant to the most potent anti-malarials has posed a serious problem to the therapy of malaria .',
  "Malaria infection during pregnancy is a serious health problem in most of the world 's tropical regions .",
  'Malaria is a serious global health problem which is especially devastating to the developing world .',
  'Malaria is a serious public health concern in several parts of India , particularly in tribal areas of Madhya Pradesh ( MP ) .',
  'Malaria , a disease caused by the protozoan parasite Plasmodium , remains a serious healthcare problem in developing countries worldwide .',
  'Plasmodium knowlesi is a monkey malaria species that is becoming a serious public health concern infecting hundreds and perhaps thousands of humans in Southeast Asia .',
  'Malaria is a devastating world health problem .',
  'Malaria remains a serious problem in French Guiana , which is at potential risk for drought linked with the El Niño Event and where there could be a risk of malaria epidemic after the onset of an El Niño event .',
  'Malaria remains a serious health problem in many parts of the world .',
  'Malaria is a serious health problem in the states of Córdoba and Antioquia , Northwestern Colombia , where 64.4 % of total Colombian cases were reported in 2007 .',
  'Transfusion-transmitted malaria remains a serious concern for blood safety .',
  'Despite considerable progress in malaria control over the past decade , malaria remains a serious problem -- particularly in Africa , south of the Sahara , where about 90 % of clinical cases occur .',
  'Anaemia is a serious problem in pregnancy in malaria-endemic countries .',
  'Malaria remains a serious health concern across the globe .',
  'Connected with perinatal diseases as well as gastrointestinal and respiratory infections malaria has been still a serious health problem of that region .',
  'Imported malaria poses a serious public health problem in Qatar because its population is " naïve " to such infection ; where local transmission might lead to serious , life-threatening infection and might even trigger epidemics .',
  'Malaria is a serious public health problem in over 90 countries worldwide .',
  'Malaria is and remains a serious health concern in Africa .',
  'Drug resistant P. falciparum in Nigeria constitutes a serious problem to malaria chemotherapy .',
  'It is recognized as a serious problem in Plasmodium falciparum-endemic sub-Saharan Africa , where recent data suggests that it is more common than previously believed .',
  'The paper concludes by arguing that malaria in urban India is a serious problem that can not be neglected .',
  'Malaria is caused by Plasmodium infection and remains a serious public health problem worldwide , despite control efforts .',
  'Malaria is a leading cause of death in developing countries , and the emergence of strains resistant to the main therapeutic agent , chloroquine , has become a serious problem .',
  'About 63 % of the respondents mentioned mosquito bite as the cause for this disease and 65 % considered malaria as a serious problem .',
  'Malaria is still a serious public health problem around the world and in our country .',
  'Participants understand that malaria is a serious problem that no single tool can defeat .',
  'Malaria , a devastating infectious parasitic disease , has been recognized by the World Health organization ( WHO ) as a major public health problem worldwide .',
  'Malaria is a serious public health problem that affects about 300 - 500 million people and claims 1.5 - 2.7 million deaths every year .',
  'Malaria in India , while decreasing , remains a serious public health problem , and the contribution of submicroscopic and asymptomatic infections to its persistence is poorly understood .',
  'The recent detection of clinical Artemisinin ( ART ) resistance manifested as delayed parasite clearance in the Cambodia-Thailand border area raises a serious concern .',
  'Malaria is a serious public health problem in Indonesia , particularly in areas outside Java and Bali .',
  'Malaria is a serious public health problem at present ; it affects almost half of the population from over 100 countries and poses a high risk of reintroduction in Cuba .',
  'Malaria is a serious public health problem in the north-eastern region of India including Assam , in view of development of chloroquine resistant Plasmodium falciparum .',
  'Drug resistance to anti-malarial compounds remains a serious problem , with resistance to newer pharmaceuticals developing at an alarming rate .',
  'Malaria was the most significant vector borne disease constituting a serious healthy problem until it was suppressed in 1965 .',
  'Malaria is a serious health concern for three billion people worldwide , killing nearly 600,000 people a year .',
  'Malaria is a serious health problem in developing countries .',
  'Malaria is still a serious public health problem in some parts of the world .',
  'The spread of chloroquine resistance poses a serious problem in Africa , where falciparum malaria transmission is the highest in the world .',
  'Malaria is a serious health problem in Colombia .',
  'Plasmodium vivax can be transmitted through the transfusions of various blood components , which became a severe problem with the safety of blood transfusions and blood-related products in ROK .',
  'The reemergence of Plasmodium vivax in South Korea since 1993 represents a serious public health concern .',
  'Malaria is a serious health problem in Malawi .',
  'The number of malaria cases is declining worldwide ; however , it remains as a serious health problem .',
  'The emergence and spread of drug-resistant malaria parasites is a serious public health problem in the tropical world .',
  'Malaria in pregnancy is a serious health problem that contributes greatly to maternal morbidity and mortality .',
  'We revisit this result using the same temperature data , now updated to the present from 1950 to 2002 for four high-altitude sites in East Africa where malaria has become a serious public health problem .',
  'The malaria caused by Plasmodium falciparum remains a serious public health problem in the world , due largely to the absence of an effective vaccine .',
  'Parental and environmental context associated with severe malaria for children under 5 years of age remains a serious public health problem that affects malaria outcomes in resource-limited areas .',
  'The recent reports of artemisinin ( ART ) resistance in the Thai-Cambodian border area raise a serious concern on the long-term efficacy of ARTs .',
  'Though intensive antimalaria efforts in Turkey have been successful in bringing down the number of cases , historically malaria was a serious public health concern .',
  'Drug resistance in Plasmodium falciparum is a serious problem in most endemic areas .',
  'Malaria remains a serious problem in global public health , particularly widespread in South America and in tropical regions of Africa and Asia .',
  'Malaria remains a devastating global health problem , resulting in many annual deaths due to the complications of severe malaria .',
  'Malaria is a life-threatening infectious disease , affecting over 250 million individuals worldwide each year , eradicating malaria has been one of the greatest challenges to public health for a century .',
  "Falciparum malaria represents a serious and an increasing world public health problem due to the acquired parasite 's resistance to the most available drugs .",
  'Infection by the parasite of malaria is a serious healthcare problem for populations residing primarily in tropical and subtropical countries .',
  'In Colombia , Plasmodium resistance to antimalarials such as chloroquine and antifolates is a serious problem .',
  'Malaria , particularly that one caused by Plasmodium falciparum , remains a serious health problem in Africa , South America , and many parts of Asia where it afflicts about 500 million people and is responsible for the death of more than one million children each year .',
  'Until the late Nineteenth century , endemic malaria was a serious public health problem in Sardinia , as in much of Southern Italy .',
  'Despite the remarkable progress that has been made to reduce global malaria mortality by 29 % in the past 5 years , malaria is still a serious global health problem .',
  'Vivax malaria , which was once thought to be a relatively benign condition , is appearing in its more malignant form , with severity gradually becoming a serious concern .',
  'Malaria is still a serious health problem in Thailand .',
  'Malaria infection is a serious public health problem throughout Liberia , but vector surveillance is limited or nonexistent in remote regions of the country .',
  'Malaria is still a serious public health problem in the world and control remains a major priority for the approximately 25.000 French troops deployed , mostly on permanent assignment , in malaria transmission regions .',
  'With an incidence of 4.5 p. 100 men.year , malaria infection remains a serious problem requiring priority status for control in military personnel .',
  'Malaria remains a serious public health problem globally .',
  'Human malaria , which is caused by infection with Plasmodium , is a serious global public health problem .',
  'Cerebral malaria ( CM ) is a life-threatening complication of Plasmodium falciparum malaria that continues to be a major global health problem .',
  'Throughout West Africa , and Liberia in particular , malaria remains a serious health concern .',
  'It is a known fact that malaria is a serious health problem worldwide due to the emergence of resistant strains .',
  'Drug resistance is a serious problem in malaria , and prospects for new drugs are not optimistic .',
  'Chloroquine resistance represents a severe problem both for prophylaxis and treatment of malaria .',
  'The spread of resistance in Plasmodium falciparum to chloroquine , the most useful of these drugs , has been a serious problem since the 1960s , and the resistant strains show various degrees of cross-resistance to other drugs .',
  'The evolutionary relationships among the apicomplexan blood pathogens known as the malaria parasites ( order Haemosporida ) , some of which infect nearly 200 million humans each year , has remained a vexing phylogenetic problem due to limitations in taxon sampling , character sampling and the extreme nucleotide base composition biases that are characteristic of this clade .',
  'IMPORTED MALARIA AS A SERIOUS PROBLEM DURING SURVEILLANCE AND CONSOLIDATION PHASES OF MALARIA ERADICATION CAMPAIGNS .',
  'Malaria disease remains a serious worldwide health problem .',
  'Malaria is a serious public health problem in many parts of the world .',
  'Malaria during pregnancy remains a serious public health problem , with substantial risks for the mother , her foetus and the newborn .',
  "Malaria and Chagas ' disease continue to be a serious problem in endemic areas , but are also of concern as a result of their introduction into other regions .",
  'Malaria was a serious problem in 39.6 % of the families surveyed in June 1999 .',
  'The rising emergence of drug resistance towards the once effective artemisinin combination therapies ( ACTs ) has become a serious concern and warrants more robust drug development strategies , with the objective of eradicating malaria infections .',
  'Imported malaria in travellers comprises only a small fraction , but the disease has become a serious problem in Europe and the United States .',
  'Malaria is a serious problem in the countries of the developing world .',
  'Although malaria has presented a significant reduction in morbidity and mortality worldwide during the last decade , it remains a serious global public health problem .',
  'Misuse of LLINs for deviant purposes is common and is a serious environmental concern , as people believe that traditional methods of prevention against malaria that have enabled them to survive through a long time are effective and sufficient .',
  'Malaria remains a serious health problem because resistance develops to all currently used drugs when their parasite targets mutate .',
  'In Colombia , malaria represents a serious public health problem .',
  'Malaria is a life-threatening health problem worldwide and treatment remains a major challenge .',
  'Malaria remains a serious public health problem in Cameroon .',
  'Malaria is an infectious disease gradually becoming a serious concern for public health institutions , even in European countries where the eradication of the disease was previously taken for granted .',
  'The resistance of Plasmodium spp . to currently used drugs has become a serious problem and efforts are being directed in obtaining new drugs with different structural features .',
  'Malaria is a serious public health problem in sub-Saharan Africa and is a leading cause of morbidity and mortality .',
  'The results of the present study reveals that malaria is still a serious health problem in Sistan and Baluchistan province , Iran .',
  'Malaria in pregnancy remains a serious public health problem in the Republic of Congo despite the implementation of intermittent preventive treatment with sulfadoxine-pyrimethamine ( IPTp-SP ) in 2006 .',
  'Despite being a serious public health concern , the geographical distribution of P. knowlesi malaria risk is poorly understood because the parasite is often misidentified as one of the human malarias .',
  'Chloroquine-resistant falciparum malaria is a serious problem in much of sub-Saharan Africa .',
  'Malaria , the most virulent parasitic disease , has become a devastating health problem in tropical and subtropical regions , especially in Africa , due to favorable temperature and rainfall conditions for the development of the causative vector .',
  'While malaria remains a serious public health concern , its rapid or prompt diagnosis in remote areas is important in the fight against the disease .',
  'Unlike the situation in Taiwan , malaria in Korea did not cause a serious health problem as in Taiwan .',
  'Placental malaria is a serious problem in sub-Saharan Africa .',
  'Malaria still remains a serious health problem in large areas of the world , and in this article , recent research progress mainly made by us toward malaria vaccine development has been reviewed .',
  'malaria is considered to be a serious health problem in Haiti , mainly in the rural zones of the coastal area located at 600 m above the sea level , particularly shallow zones with rice crops .',
  'French Guiana is one of the areas in South America most affected by malaria and where the disease has become a serious public health problem .',
  'Malaria is a serious health concern in Africa .',
  'Malaria is a serious public concern in Ethiopia , 75 % of the land and 60 % of the population are exposed to the disease .',
  'The emergence and spread of Plasmodium falciparum parasite resistant to sulfadoxine and pyrimethamine ( SP ) poses a serious public health problem .',
  'Although there is acceptable knowledge ( about 80 % of the subject knew that mosquito bite causes malaria ) and positive attitude towards malaria ( 100 % of respondents agreed that malaria was a serious health problem in this area and 97 % of respondents agreed that they would like to participate in malaria control activities ) , it is necessary to increase the community awareness of the transmission of the disease , its consequences and ways and means to control the disease to a minimum , especially in endemic areas .',
  'Over-diagnosis of malaria and over-treatment with antimalarials was found to be a serious problem .',
  'Malaria still constitutes a serious public health problem in Nigeria despite control efforts .',
  'Despite tremendous progress , malaria remains a serious public health problem in Pakistan .',
  'This species acts as a vector of Plasmodium vivax , an important etiological agent of malaria , which represents a serious public health problem .',
  'Hyperparasitemia itself might be important for the development of a fatal event in malaria , but a recommendation to perform a dangerous , expensive , and labor-intensive procedure such as blood exchange transfusion for its treatment should be based on substantial clinical research , especially in areas where malaria is a major health problem .',
  'Despite a resurgence in control efforts , malaria remains a serious public-health problem , causing millions of deaths each year .',
  'Malaria is a serious health problem in many of the countries from which refugees come to Australia .',
  'Increasing parasite resistance to nearly all available antimalarial drugs becomes a serious problem to human health and necessitates the need to continue the search for new effective drugs .',
  '92.5 % of the study population considered malaria to be a serious health problem , thus reflecting their attitude to the disease .',
  'Malaria during pregnancy remains a serious public health problem .',
  'In Colombia , with higher frequency of Plasmodium vivax over Plasmodium falciparum infection , recent reports confirmed gestational malaria as a serious public health problem .',
  'Urban malaria can be a serious public health problem in Africa .',
  'Malaria is a life-threatening disease of global concern .',
  'Malaria remains a serious public health problem with significant morbidity and mortality accounting for nearly 20 % of all childhood deaths in Africa .',
  'Nevertheless , malaria remains a serious health concern , and Uganda ranks third in SSA in total malaria burden .',
  'The malaria parasite resistance to the existing drugs is a serious problem to the currently used antimalarials and , thus , highlights the urgent need to develop new and effective anti-malarial molecules .',
  'Malaria remains a serious public health problem , especially in developing countries .',
  'The prevalence of morbidity and mortality from drug resistant malaria ( Plasmodium falciparum ) is increasing in most of the developing countries , which is also a global threat because international travel is common now and imported malaria is increasingly a serious problem .',
  'Malaria used to be a serious health problem in Fujian province in the past , but no local malaria transmission has been found since 2000 .',
  'A large number of oil fields and related installations in Assam are located in forest areas or on their fringes where malaria is a serious problem among field staff and security personnel , adversely affecting oil production .',
  'Plasmodium falciparum malaria imposes a serious public health concern throughout the tropics .',
  'This raises a serious concern on the long-term efficacy of artemisinin-based combination therapies , as these combination therapies currently constitute the last effective and most tolerable treatment for multidrug-resistant Plasmodium falciparum .',
  'Malaria remains a serious clinical and public health problem , the object of an ongoing technological and humanitarian struggle to abate the very substantial harm done .',
  'Malaria represents a serious public health problem , presenting with high rates of incidence , morbidity and mortality in tropical and subtropical regions of the world .',
  'Despite progress in the control of malaria , it remains a serious public health problem .',
  'Malaria is a serious problem in the Brazilian Amazon region , and the detection of possible risk factors could be of great interest for public health authorities .',
  'Malaria remains a serious problem for ADF soldiers deploying to malarious areas , particularly the incidence of relapsing vivax malaria and the tolerance of these vivax strains to primaquine .',
  'Malaria is still a serious health problem in Thailand .',
  'Malaria is one of the most prevalent vector borne infectious disease and a serious global health problem in the world .',
  'Malaria is a serious public health problem , the control of which involves actions directed against its vector , mosquitoes of the genus Anopheles Meigan , 1818 .',
  'For decades , malaria was a serious public health problem in Puerto Rico .',
  'Placental malaria ( PM ) remains a severe public health problem in areas of high malaria transmission .',
  'Malaria , transmitted by anopheline mosquitoes , remains a serious health problem in the tropics .',
  'Malaria during pregnancy remains a serious public health problem .',
  'Malaria remains a serious public health problem with significant morbidity and mortality .',
  'Malaria is a life-threatening disease and , what is more , the resistance to available antimalarial drugs is a recurring problem . The resistance of',
  'Nowadays , it occurs in Santiago Island alone and though prophylaxis is not recommended by the World Health Organization , studies have highlight the prospect of malaria becoming a serious public health problem as a result of the presence of antimalarial drug resistance associated with mutations in the parasite populations and underscore the need for tighter surveillance .',
  'Malaria is a serious public health problem in numerous countries of the world .',
  'Malaria is a serious public health problem of the world especially in Africa and Asia where the areas are located in the tropical and subtropical regions .',
  'Malaria transmission is a serious emergence in urban and semiurban areas worldwide , becoming a major international public health concern .',
  'Regarding degedege as a separate entity may explain why malaria is not perceived as a serious health problem in the area , and why little preventive actions are taken .',
  'For this reason , the increasing prevalence of strains of Plasmodium falciparum resistant to chloroquine and other antimalarial drugs poses a serious problem for control of malaria .',
  'Malaria , a life-threatening blood disease , has been a major concern in the field of healthcare .',
  'Malaria was a serious problem on the campus of the complex and routine methods of malaria control by providing screened doors , larviciding , fogging , limited spraying in the unauthorized colonies and chemotherapy were not effective .',
  'To assess the level of adherence to standard treatment guidelines among clinicians prescribing treatment for children admitted with a diagnosis of malaria and/or lower respiratory tract infection ( LRTI ) , and determine the association between ( non ) adherence and hospital outcomes , given that non-rational use of medicines is a serious global problem .',
  'These observations highlight the alarming prospect of malaria to become a serious public health problem and underscore the need for a tighter surveillance .',
  'Malaria infections remain a serious global health problem in the world , particularly among children and pregnant women in Sub-Saharan Africa .',
  'These massive increases in morbidity have devastating impact on the affected communities and highlight that malaria epidemics are a serious and increasing public health problem in the highlands of Papua New Guinea .',
  'Malaria is a serious global health problem , and rapid , accurate diagnosis is required to control the disease .',
  'Malaria remains a severe health problem in Sub-Saharan Africa , with approximately one million deaths and 365 million cases each year .',
  'Malaria continues to be a serious public health problem particularly in Africa .',
  'Malaria is an important tropical disease and has remained a serious health problem in many countries .',
  'Malaria , caused by the Plasmodium parasite , remains a serious global public health concern .'],
 'uranium': ['The development of a new class of carbon electrocatalysts for nitrate reduction reaction ( NRR ) that have high activity and durability is extremely important , as currently reported metallic electrocatalysts show a main drawback of low stability owing to leaching and oxidation .',
  'Therefore , at present , it faces a serious problem due to aging equipment , especially those directly in contact with the environment such as the underground settling tanks of nuclear and radioactive waste .',
  'The accumulation of radionuclides can be a serious problem especially when this sludge is going to be reused , so more exhaustive information is required to prevent the possible radiological impact of these samples in the environment and also on the people .',
  'The migration of the uranium ( U ) in high-level radioactive waste that is held in deep geological repositories via fractures in deep granite aquifers is a serious safety concern , thus , this study investigates the effect of fracture filling materials designed to mitigate these concerns .',
  'With the increasing demand for new energy , nuclear industry has been developing very fast , and uranium ( U ) pollution becomes a serious environmental problem especially in the mining area .',
  'Remediation of these systems turns into a serious problem due to various anthropogenic activities that have significantly raised the amount of heavy metals and radionuclides in it .',
  'High concentrations of uranium(VI ) in the Witwatersrand Basin , South Africa from mining leachate is a serious environmental concern .',
  'Radiocesium contamination of forests has been a severe problem after the Fukushima Daiichi Nuclear Power Plant accident in 2011 .',
  'Uranium contamination is a serious concern at several sites motivating the development of novel treatment strategies such as the Geobacter-mediated reductive immobilization of uranium .',
  'Uranium contamination in the environment is a serious public health concern .',
  'Environmental contamination by uranium ( U ) and other radionuclides is a serious problem worldwide , especially due to , e.g. mining activities .'],
 'radionuclides': ['The development of a new class of carbon electrocatalysts for nitrate reduction reaction ( NRR ) that have high activity and durability is extremely important , as currently reported metallic electrocatalysts show a main drawback of low stability owing to leaching and oxidation .',
  'Therefore , at present , it faces a serious problem due to aging equipment , especially those directly in contact with the environment such as the underground settling tanks of nuclear and radioactive waste .',
  'The accumulation of radionuclides can be a serious problem especially when this sludge is going to be reused , so more exhaustive information is required to prevent the possible radiological impact of these samples in the environment and also on the people .',
  'The migration of the uranium ( U ) in high-level radioactive waste that is held in deep geological repositories via fractures in deep granite aquifers is a serious safety concern , thus , this study investigates the effect of fracture filling materials designed to mitigate these concerns .',
  'With the increasing demand for new energy , nuclear industry has been developing very fast , and uranium ( U ) pollution becomes a serious environmental problem especially in the mining area .',
  'Remediation of these systems turns into a serious problem due to various anthropogenic activities that have significantly raised the amount of heavy metals and radionuclides in it .',
  'High concentrations of uranium(VI ) in the Witwatersrand Basin , South Africa from mining leachate is a serious environmental concern .',
  'Radiocesium contamination of forests has been a severe problem after the Fukushima Daiichi Nuclear Power Plant accident in 2011 .',
  'Uranium contamination is a serious concern at several sites motivating the development of novel treatment strategies such as the Geobacter-mediated reductive immobilization of uranium .',
  'Uranium contamination in the environment is a serious public health concern .',
  'Environmental contamination by uranium ( U ) and other radionuclides is a serious problem worldwide , especially due to , e.g. mining activities .'],
 'nuclear': ['The development of a new class of carbon electrocatalysts for nitrate reduction reaction ( NRR ) that have high activity and durability is extremely important , as currently reported metallic electrocatalysts show a main drawback of low stability owing to leaching and oxidation .',
  'Therefore , at present , it faces a serious problem due to aging equipment , especially those directly in contact with the environment such as the underground settling tanks of nuclear and radioactive waste .',
  'The accumulation of radionuclides can be a serious problem especially when this sludge is going to be reused , so more exhaustive information is required to prevent the possible radiological impact of these samples in the environment and also on the people .',
  'The migration of the uranium ( U ) in high-level radioactive waste that is held in deep geological repositories via fractures in deep granite aquifers is a serious safety concern , thus , this study investigates the effect of fracture filling materials designed to mitigate these concerns .',
  'With the increasing demand for new energy , nuclear industry has been developing very fast , and uranium ( U ) pollution becomes a serious environmental problem especially in the mining area .',
  'Remediation of these systems turns into a serious problem due to various anthropogenic activities that have significantly raised the amount of heavy metals and radionuclides in it .',
  'High concentrations of uranium(VI ) in the Witwatersrand Basin , South Africa from mining leachate is a serious environmental concern .',
  'Radiocesium contamination of forests has been a severe problem after the Fukushima Daiichi Nuclear Power Plant accident in 2011 .',
  'Uranium contamination is a serious concern at several sites motivating the development of novel treatment strategies such as the Geobacter-mediated reductive immobilization of uranium .',
  'Uranium contamination in the environment is a serious public health concern .',
  'Environmental contamination by uranium ( U ) and other radionuclides is a serious problem worldwide , especially due to , e.g. mining activities .'],
 'electrocatalysts': ['The development of a new class of carbon electrocatalysts for nitrate reduction reaction ( NRR ) that have high activity and durability is extremely important , as currently reported metallic electrocatalysts show a main drawback of low stability owing to leaching and oxidation .',
  'Therefore , at present , it faces a serious problem due to aging equipment , especially those directly in contact with the environment such as the underground settling tanks of nuclear and radioactive waste .',
  'The accumulation of radionuclides can be a serious problem especially when this sludge is going to be reused , so more exhaustive information is required to prevent the possible radiological impact of these samples in the environment and also on the people .',
  'The migration of the uranium ( U ) in high-level radioactive waste that is held in deep geological repositories via fractures in deep granite aquifers is a serious safety concern , thus , this study investigates the effect of fracture filling materials designed to mitigate these concerns .',
  'With the increasing demand for new energy , nuclear industry has been developing very fast , and uranium ( U ) pollution becomes a serious environmental problem especially in the mining area .',
  'Remediation of these systems turns into a serious problem due to various anthropogenic activities that have significantly raised the amount of heavy metals and radionuclides in it .',
  'High concentrations of uranium(VI ) in the Witwatersrand Basin , South Africa from mining leachate is a serious environmental concern .',
  'Radiocesium contamination of forests has been a severe problem after the Fukushima Daiichi Nuclear Power Plant accident in 2011 .',
  'Uranium contamination is a serious concern at several sites motivating the development of novel treatment strategies such as the Geobacter-mediated reductive immobilization of uranium .',
  'Uranium contamination in the environment is a serious public health concern .',
  'Environmental contamination by uranium ( U ) and other radionuclides is a serious problem worldwide , especially due to , e.g. mining activities .'],
 'olive': ['Accordingly , the aim of this research work was to evaluate strategies for the development of a virgin olive oil enriched with phenolic compounds obtained from olive cake to increase phenolic ingestion without the drawback of a higher calorie intake .',
  'Olive mill wastewater ( OMW ) , a liquid by-product of the olive oil industry , represents a severe environmental problem owing to its high pollution load .',
  'The management of the wastewater originating from olive oil producing industries poses a serious environmental problem .',
  'The illegal cooking oil has become a serious social problem and raised widespread alarm recently .',
  'Olive mill eflluent ( OME ) wastewater represents a serious environmental problem in the Mediterranean area .',
  'Unfortunately , the increasing market demand towards virgin olive oil could often result in its adulteration with less expensive oils , which is a serious problem for the public and quality control evaluators of virgin olive oil .',
  'Olive mill wastewaters ( OMW ) pose a serious environmental concern owing to high polyphenol content .',
  'Adulteration of virgin olive oil with less expensive oils such as hazelnut oil is a serious problem for quality control of olive oil .',
  'Olive mills wastewater ( OMW ) causes a serious environmental problem in the olive oil producing countries .',
  "This activity , however , may represent a serious environmental problem due to the discharge of highly polluted effluents , usually referred to as ' olive mill wastewaters ' ( OMWs ) .",
  'This wastewater material , containing a high level of phenolic compounds , poses a serious environmental problem in almost all Mediterranean countries .',
  'The contamination of soils with dry olive-mill residue can represent a serious problem as being an environmental stressor in plants .',
  'Adulteration of extra virgin olive oil ( EVOO ) with hazelnut oil ( HAO ) is a serious concern both for oil suppliers and consumers .',
  'Illegal cooking oil ( ICO , also named swill-cooked dirty oil ) has recently become a serious food safety problem in China .',
  'Table olive processing wastewaters constitute a dangerous environmental problem in the Mediterranean countries because of their large volumes , high organic matter and salt concentration .',
  'Wastewater from the olive mill constitutes a serious environmental concern , as it is characterized by a high inorganic and organic load .',
  'Olive oil production , one of the main agro-industries in Mediterranean countries , generates significant amounts of olive mill wastewaters ( OMWs ) , which represent a serious environmental problem , because of their high organic load , the acidic pH and the presence of recalcitrant and toxic substances such as phenolic and lipidic compounds ( up to several grams per litre ) .',
  'Olive mill effluents constitute a serious environmental problem in the Mediterranean Sea region due to the unique features associated with this type of agro-waste ( i.e. seasonal and localized production , high and diverse organic load , low flow rates )',
  'The adulteration of extra virgin olive oil ( EVOO ) with hazelnut oil ( HO ) is frequent and constitutes a serious concern both for oil suppliers and consumers .',
  'Olive mill wastewaters ( OMW ) can be a severe problem when disposed of as untreated because of their high organic load , elevated concentration of polyphenols , and moderately low biodegradability .',
  'Palm oil mill effluent ( POME ) is a serious and expensive environmental problem in Malaysia .'],
 'oil': ['Accordingly , the aim of this research work was to evaluate strategies for the development of a virgin olive oil enriched with phenolic compounds obtained from olive cake to increase phenolic ingestion without the drawback of a higher calorie intake .',
  'Olive mill wastewater ( OMW ) , a liquid by-product of the olive oil industry , represents a severe environmental problem owing to its high pollution load .',
  'The management of the wastewater originating from olive oil producing industries poses a serious environmental problem .',
  'The illegal cooking oil has become a serious social problem and raised widespread alarm recently .',
  'Olive mill eflluent ( OME ) wastewater represents a serious environmental problem in the Mediterranean area .',
  'Unfortunately , the increasing market demand towards virgin olive oil could often result in its adulteration with less expensive oils , which is a serious problem for the public and quality control evaluators of virgin olive oil .',
  'Olive mill wastewaters ( OMW ) pose a serious environmental concern owing to high polyphenol content .',
  'Adulteration of virgin olive oil with less expensive oils such as hazelnut oil is a serious problem for quality control of olive oil .',
  'Olive mills wastewater ( OMW ) causes a serious environmental problem in the olive oil producing countries .',
  "This activity , however , may represent a serious environmental problem due to the discharge of highly polluted effluents , usually referred to as ' olive mill wastewaters ' ( OMWs ) .",
  'This wastewater material , containing a high level of phenolic compounds , poses a serious environmental problem in almost all Mediterranean countries .',
  'The contamination of soils with dry olive-mill residue can represent a serious problem as being an environmental stressor in plants .',
  'Adulteration of extra virgin olive oil ( EVOO ) with hazelnut oil ( HAO ) is a serious concern both for oil suppliers and consumers .',
  'Illegal cooking oil ( ICO , also named swill-cooked dirty oil ) has recently become a serious food safety problem in China .',
  'Table olive processing wastewaters constitute a dangerous environmental problem in the Mediterranean countries because of their large volumes , high organic matter and salt concentration .',
  'Wastewater from the olive mill constitutes a serious environmental concern , as it is characterized by a high inorganic and organic load .',
  'Olive oil production , one of the main agro-industries in Mediterranean countries , generates significant amounts of olive mill wastewaters ( OMWs ) , which represent a serious environmental problem , because of their high organic load , the acidic pH and the presence of recalcitrant and toxic substances such as phenolic and lipidic compounds ( up to several grams per litre ) .',
  'Olive mill effluents constitute a serious environmental problem in the Mediterranean Sea region due to the unique features associated with this type of agro-waste ( i.e. seasonal and localized production , high and diverse organic load , low flow rates )',
  'The adulteration of extra virgin olive oil ( EVOO ) with hazelnut oil ( HO ) is frequent and constitutes a serious concern both for oil suppliers and consumers .',
  'Olive mill wastewaters ( OMW ) can be a severe problem when disposed of as untreated because of their high organic load , elevated concentration of polyphenols , and moderately low biodegradability .',
  'Palm oil mill effluent ( POME ) is a serious and expensive environmental problem in Malaysia .'],
 'wastewaters': ['Accordingly , the aim of this research work was to evaluate strategies for the development of a virgin olive oil enriched with phenolic compounds obtained from olive cake to increase phenolic ingestion without the drawback of a higher calorie intake .',
  'Olive mill wastewater ( OMW ) , a liquid by-product of the olive oil industry , represents a severe environmental problem owing to its high pollution load .',
  'The management of the wastewater originating from olive oil producing industries poses a serious environmental problem .',
  'The illegal cooking oil has become a serious social problem and raised widespread alarm recently .',
  'Olive mill eflluent ( OME ) wastewater represents a serious environmental problem in the Mediterranean area .',
  'Unfortunately , the increasing market demand towards virgin olive oil could often result in its adulteration with less expensive oils , which is a serious problem for the public and quality control evaluators of virgin olive oil .',
  'Olive mill wastewaters ( OMW ) pose a serious environmental concern owing to high polyphenol content .',
  'Adulteration of virgin olive oil with less expensive oils such as hazelnut oil is a serious problem for quality control of olive oil .',
  'Olive mills wastewater ( OMW ) causes a serious environmental problem in the olive oil producing countries .',
  "This activity , however , may represent a serious environmental problem due to the discharge of highly polluted effluents , usually referred to as ' olive mill wastewaters ' ( OMWs ) .",
  'This wastewater material , containing a high level of phenolic compounds , poses a serious environmental problem in almost all Mediterranean countries .',
  'The contamination of soils with dry olive-mill residue can represent a serious problem as being an environmental stressor in plants .',
  'Adulteration of extra virgin olive oil ( EVOO ) with hazelnut oil ( HAO ) is a serious concern both for oil suppliers and consumers .',
  'Illegal cooking oil ( ICO , also named swill-cooked dirty oil ) has recently become a serious food safety problem in China .',
  'Table olive processing wastewaters constitute a dangerous environmental problem in the Mediterranean countries because of their large volumes , high organic matter and salt concentration .',
  'Wastewater from the olive mill constitutes a serious environmental concern , as it is characterized by a high inorganic and organic load .',
  'Olive oil production , one of the main agro-industries in Mediterranean countries , generates significant amounts of olive mill wastewaters ( OMWs ) , which represent a serious environmental problem , because of their high organic load , the acidic pH and the presence of recalcitrant and toxic substances such as phenolic and lipidic compounds ( up to several grams per litre ) .',
  'Olive mill effluents constitute a serious environmental problem in the Mediterranean Sea region due to the unique features associated with this type of agro-waste ( i.e. seasonal and localized production , high and diverse organic load , low flow rates )',
  'The adulteration of extra virgin olive oil ( EVOO ) with hazelnut oil ( HO ) is frequent and constitutes a serious concern both for oil suppliers and consumers .',
  'Olive mill wastewaters ( OMW ) can be a severe problem when disposed of as untreated because of their high organic load , elevated concentration of polyphenols , and moderately low biodegradability .',
  'Palm oil mill effluent ( POME ) is a serious and expensive environmental problem in Malaysia .'],
 'phenolic': ['Accordingly , the aim of this research work was to evaluate strategies for the development of a virgin olive oil enriched with phenolic compounds obtained from olive cake to increase phenolic ingestion without the drawback of a higher calorie intake .',
  'Olive mill wastewater ( OMW ) , a liquid by-product of the olive oil industry , represents a severe environmental problem owing to its high pollution load .',
  'The management of the wastewater originating from olive oil producing industries poses a serious environmental problem .',
  'The illegal cooking oil has become a serious social problem and raised widespread alarm recently .',
  'Olive mill eflluent ( OME ) wastewater represents a serious environmental problem in the Mediterranean area .',
  'Unfortunately , the increasing market demand towards virgin olive oil could often result in its adulteration with less expensive oils , which is a serious problem for the public and quality control evaluators of virgin olive oil .',
  'Olive mill wastewaters ( OMW ) pose a serious environmental concern owing to high polyphenol content .',
  'Adulteration of virgin olive oil with less expensive oils such as hazelnut oil is a serious problem for quality control of olive oil .',
  'Olive mills wastewater ( OMW ) causes a serious environmental problem in the olive oil producing countries .',
  "This activity , however , may represent a serious environmental problem due to the discharge of highly polluted effluents , usually referred to as ' olive mill wastewaters ' ( OMWs ) .",
  'This wastewater material , containing a high level of phenolic compounds , poses a serious environmental problem in almost all Mediterranean countries .',
  'The contamination of soils with dry olive-mill residue can represent a serious problem as being an environmental stressor in plants .',
  'Adulteration of extra virgin olive oil ( EVOO ) with hazelnut oil ( HAO ) is a serious concern both for oil suppliers and consumers .',
  'Illegal cooking oil ( ICO , also named swill-cooked dirty oil ) has recently become a serious food safety problem in China .',
  'Table olive processing wastewaters constitute a dangerous environmental problem in the Mediterranean countries because of their large volumes , high organic matter and salt concentration .',
  'Wastewater from the olive mill constitutes a serious environmental concern , as it is characterized by a high inorganic and organic load .',
  'Olive oil production , one of the main agro-industries in Mediterranean countries , generates significant amounts of olive mill wastewaters ( OMWs ) , which represent a serious environmental problem , because of their high organic load , the acidic pH and the presence of recalcitrant and toxic substances such as phenolic and lipidic compounds ( up to several grams per litre ) .',
  'Olive mill effluents constitute a serious environmental problem in the Mediterranean Sea region due to the unique features associated with this type of agro-waste ( i.e. seasonal and localized production , high and diverse organic load , low flow rates )',
  'The adulteration of extra virgin olive oil ( EVOO ) with hazelnut oil ( HO ) is frequent and constitutes a serious concern both for oil suppliers and consumers .',
  'Olive mill wastewaters ( OMW ) can be a severe problem when disposed of as untreated because of their high organic load , elevated concentration of polyphenols , and moderately low biodegradability .',
  'Palm oil mill effluent ( POME ) is a serious and expensive environmental problem in Malaysia .'],
 'mrsa': ['A major drawback of mecA PCR to detect methicillin-resistant Staphylococcus aureus ( MRSA ) directly from patient materials is the high frequency of methicillin-resistant coagulase-negative staphylococci .',
  '[ Methicillin-resistant Staphylococcus aureus : a serious problem for the patient ] .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) has recently become a serious problem in various fields of medicine .',
  'MRSA bacteraemia is now a serious problem in children in England and Wales .',
  'The growing emergency of infections with community-acquired methicillin-resistant Staphylococcus aureus ( CA-MRSA ) secreting the Panton-Valentine toxin ( PVL ) has become a serious health problem with epidemic proportions .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) poses a serious therapeutic problem worldwide , and its frequency in most African countries has not been reported .',
  'In the last decades , MRSA started as a serious problem only in hospitals , but in recent years it also rose as an alarming community pathogen .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) , that have acquired multiresistance to all classes of antibiotics , have become a serious nosocomial problem .',
  'Vancomycin has been the drug of choice for the treatment of multiresistant MRSA infections in the last three decades , but the management of invasive MRSA infections will become a serious problem if VISA strains become widespread .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) infections are a serious global problem , with considerable impact on patients and substantial health care costs .',
  'Methicillin resistant Staphylococcus aureus ( MRSA ) constitute a serious health care problem worldwide .',
  'Identification of methicillin-resistant Staphylococcus aureus by drug-susceptibility tests alone poses a serious problem , because a considerable number of clinical S. aureus isolates are borderline resistant to methicillin .',
  'The high prevalence of CA-MRSA carriage in the population could pose a serious public health concern for the region .',
  'Staphylococcus aureus is an important cause of food intoxication , whereas methicillin-resistant S. aureus ( MRSA ) constitutes a serious public-health concern due to its ability to colonize and infect humans and animals .',
  'PRACTICAL APPLICATIONS : Methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious concern in hospitals because of its known antibiotic resistance .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) strains are a major cause of hospital-acquired infections and are considered a serious public health concern .',
  'Bacterial resistance to antibiotics is a serious global problem and includes strains of beta-lactam-resistant Staphylococcus aureus and methicillin-resistant S. aureus ( MRSA ) .',
  'MRSA remains a serious problem because of the high incidence and multidrug resistance of the strains , even for strains isolated from foods , food environments and food handlers .',
  'Nosocomial infections caused by methicillin-resistant staphylococci ( MRSA ) pose a serious problem in many countries .',
  'This report demonstrates that family members can serve as reservoirs of CA-MRSA which may become a serious problem in containing the spread of MRSA .',
  'The widespread emergence of methicillin resistant Staphylococcus aureus , as a common cause of nosocomial infections , is becoming a serious concern in global public health .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) continues to be a serious human pathogen , and particularly the spread of community associated (CA)-MRSA strains such as USA300 is a concern , as these strains can cause severe infections in otherwise healthy adults .',
  'Infection by methicillin-resistant Staphylococcus aureus ( MRSA ) presents a serious problem , as these organisms are resistant to a wide range of antibiotics .',
  'Methicillin-resistant Staphylococcus aureus infection is a serious clinical problem worldwide .',
  'Community-associated methicillin resistant Staphylococcus aureus ( CA-MRSA ) has become a severe health concern because of its treatment difficulties .',
  'Nosocomial infections involving epidemic methicillin-resistant Staphylococcus aureus ( MRSA ) strains are a serious problem in many countries .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) commonly causes refractory infections and has recently become a serious public health concern .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) has become a serious problem in intensive care units , because of development of multiresistance , and also intrinsic resistance to beta-lactam antibiotics .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) infection is a serious clinical problem worldwide .',
  'An increasing prevalence of methicillin-resistant Staphylococcus aureus ( MRSA ) has created a serious therapeutic problem .',
  'In Japan , most strains of MRSA now represent high level resistance to all antibiotics , except for a few antibiotics , such as vancomycin and arbekacin , and therefore , they posed a serious problem clinically and epidemiologically , via immuno-suppressed inpatients , in particular , as the causative pathogen of nosocomial infection .',
  'Multidrug-resistance of methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious therapeutical problem .',
  'Although severe infection caused by methicillin-resistant Staphylococcus aureus ( MRSA ) has become a serious social problem in medical facilities , it is relatively uncommon in the urological field .',
  'Infections caused by hard-to-treat methicillin-resistant Staphylococcus aureus ( MRSA ) are a serious global public-health concern , as MRSA has become broadly resistant to many classes of antibiotics .',
  'Methicillin-resistant Staphylococcus aureus-related infections have become a serious problem worldwide .',
  'Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment , especially methicillin-resistant S. aureus ( MRSA ) .',
  'Staphylococcus aureus harboured by Panton-Valentine leukocidin ( PVL ) is emerging as a serious problem worldwide .',
  'The presence of methicillin-resistant Staphylococcus aureus ( MRSA ) in hospitals and the community is a serious problem .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) is a life-threatening pathogen in humans and its presence in animals is a public health concern .',
  'The emergence of these infections is a serious therapeutic problem , since vancomycine is a major antibiotic used in the treatment of meticillin-resistant S. aureus ( MRSA ) infections .',
  'The frequent importation of PVL-positive CA-MRSA into healthcare settings , transmission and association with outbreaks is a serious ongoing concern .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) has emerged as a serious problem in the community .',
  'MRSA is a serious clinical and epidemiologic problem .',
  'The results indicate that MRSHo with high antibiotic resistance and unknown SCCmec might become a serious problem in the future for the treatment of patients such as children .',
  'The investigation of methicillin resistance in Staphylococcus aureus ( MRSA ) is a serious problem for the physician and microbiologist .',
  'Emergence of drug resistant strains especially methicillin resistant S. aureus ( MRSA ) is a serious problem in hospital environment .',
  'Very low birthweight or premature infants had become the targets of MRSA infection and this has now become a serious problem .',
  'Staphylococcus aureus , particularly methicillin-resistant S.aureus ( MRSA ) , is a life-threatening pathogen in humans , and its presence in food is a public health concern .',
  'The high resistance acquired by MRSA needs a serious concern and efforts should be carried out for the discovery of better therapeutics .',
  'Appearance of MRSA strains in the community is becoming a serious public health problem .',
  'The global spread of methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious problem , particularly in mainland China .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) is spreading worldwide and poses a serious public health problem , being present in hospital settings and communities .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) isolates is a serious public health problem whose ever-increasing rate is commensurate with the pressure it is exerting on the healthcare system .',
  'The prevalence of community-acquired meticillin-resistant Staphylococcus aureus ( CA-MRSA ) strains has become a serious problem worldwide .',
  'Therefore , MRSA strains have become a serious problem in the clinical setting .',
  'MRSA infection poses a serious problem for physicians and their patients .',
  "Infections with methicillin-resistant Staphylococcus aureus ( MRSA ) and methicillin-resistant coagulase-negative Staphylococcus ( MR-CNS ) are a serious problem in hospitals because these bacteria produce penicillin-binding protein 2 ' ( PBP2 ' or PBP2a ) , which shows low affinity to β-lactam antibiotics .",
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) has been a serious problem as its infection is associated with higher mortality and increase cost worldwide .',
  'The results indicate that MRSC with high antibiotic resistance and unknown SCCmec might become a serious problem in the future for the treatment of patients particularly children .',
  'The presence and dissemination of community-associated MRSA containing vanA could become a serious public health concern .',
  'Detection of methicillin-resistant Staphylococcus aureus ( MRSA ) isolates represents a serious problem to low and media level microbiology labs .',
  'Bacterial contamination of surfaces with methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious problem in the hospital environment and is responsible for significant nosocomial infections .',
  'Community-associated methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious public health concern and in Australia , one that disproportionately affects Aboriginal people .',
  'Infections caused by methicillin-resistant Staphylococcus aureus pose a serious problem postoperatively .',
  'Methicillin resistance in Staphylococcus aureus and in coagulase-negative staphylococci represents a serious problem both for the microbiologist and the physician .',
  'Methicillin-Resistant Staphylococcus aureus ( MRSA ) , which is resistant to many antibiotics , creates a serious problem for human health if present in food .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious nosocomial problem , globally distributed .',
  'The emergence of methicillin-resistant S. pseudintermedius ( MRSP ) is also becoming a serious concern .',
  'The presence of nosocomial MRSA is a serious medical problem which requires continued attention to care in the overuse of antibiotics and indwelling devices in hospitals .',
  'The increasing prevalence of community-acquired MRSA and its emerging antibiotic resistance in foods is a serious problem for public health .',
  'Methicillin-resistant strains of Staphylococcus aureus ( MRSA ) constitute a serious diagnostic and therapeutic problem .',
  'Community-acquired methicillin-resistant Staphylococcus aureus ( CA-MRSA ) may represent a serious public health problem , owing to the spread of toxin-producing lineages .',
  'Due mainly to indiscriminate abuse of antibiotics , the methicillin-resistant strain known by its initials as MRSA is the most extended nosocomial infection globally and is a severe community and hospital healthcare problem .',
  'Infections caused by clinical methicillin-resistant Staphylococcus aureus ( MRSA ) are a serious public problem .',
  'Methicillin-Resistant Staphylococcus Aureus ( MRSA ) has been widely recognized as a serious problem in hospital settings .',
  'Methicillin-resistant staphylococcus aureus ( MRSA ) bacteremia is a life-threatening illness and a major global health care problem .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) poses a serious problem in some geographic areas .',
  'Antimicrobial resistance of methicillin-resistant Staphylococcus aureus ( MRSA ) poses a serious problem for clinicians worldwide .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) isolates are a serious public health problem whose ever-increasing rate is commensurate with the pressure it is exerting on the healthcare system .',
  'It is concluded that the emergence of methicillin and gentamicin-tobramycin resistance among hospital staphylococci represents a serious , persistent problem .',
  "Everybody agrees that infection control is a serious problem and that something needs to be done about it , but nobody can agree exactly what . In this week 's special report , we look at NHS plans to improve the worst MRSA record in Europe .",
  'Infections with MRSA strains that are resistant to beta-lactams and other types of antibiotics are a serious therapeutic problem - first , because in such cases only a limited spectrum of antibiotics can be used ; and second , because such infections require prolonged hospitalization and result in economic losses .',
  'Misidentification of nosocomial S. aureus as MRSA is a serious problem in Libyan hospitals .',
  'Methicillin-resistant Staphylococcus remains a severe public health problem worldwide .',
  'Nosocomial methicillin-resistant Staphylococcus aureus ( MRSA ) infection in infants has become a serious concern and a new means of preventing the transmission of MRSA in the community needs to be considered .',
  'Emergence of drug resistant strains especially methicillin resistant Staphylococcus aureus is a serious problem in hospital environments .',
  'Meticillin-resistant Staphylococcus aureus ( MRSA ) is a major pathogen responsible for significant numbers of healthcare-associated infections and isolates containing Panton-Valentine leukocidin ( PVL ) that cause severe skin infections are emerging as a serious problem .',
  'Today , significant increase in the prevalence and emergence of methicillin-resistant Staphylococcus aureus ( MRSA ) is a serious public health concern and is likely to have a dramatic negative impact on many current medical practices .',
  'The presence of MRSA in the in-patients is a serious problem as it can act as reservoir to cause outbreak of colonisation and infection .',
  'An increasing prevalence of methicillin-resistant Staphylococcus ( S. ) aureus ( MRSA ) has a serious therapeutic problem , and accurate methods to detect such strains are needed .'],
 'otitis': ['However , if the primary otoplasty technique is a cartilage-sculpting method , the efficiency of this technique remains unknown because no patient in this study had cartilage-sculpting otoplasty as primary otoplasty , which is possibly the main drawback of this study .',
  'Hypertrophic adenoids with otitis media with effusion is a common infectious disease and present a serious otological problem in children .',
  'Ototoxicity is a serious health problem that greatly affects millions of people worldwide .',
  'Serous otitis media : a serious problem .',
  'The treatment of cholesteatoma in patients without a permanent residence or in medically underdeveloped countries presents a serious problem in middle ear surgery .',
  'Unresolved otitis media ; a serious new problem .',
  'The extremely high prevalence of otitis media , in spite of sophisticated innate and adaptive immune systems , is a vexing problem for clinicians and scientists .',
  'Chronic suppurative otitis media is a serious health problem worldwide .',
  'Their ototoxicity is a serious health problem and , as their ototoxic mechanism involves the production of NO , we need to assess the use of NO inhibitors for the prevention of aminoglycoside-induced sensorineural hearing loss .',
  '[ Intracranial otogenic complications : inspite of therapeutic progress still a serious problem ] .',
  'In 10.4 % of the cases , otorrhea was noticed ; it formed a serious problem in 3.1 % of the ears .',
  'Non-tuberculous otomastoiditis is a severe ear disease with challenging considerations , and should be treated aggressively in order to avoid morbidity .',
  'Acute otitis media ( AOM ) is a serious health concern for millions of children .',
  'Otitis media can be a vexing , recurrent problem .',
  'The lack of precision in nomenclature is a serious problem for the inner ear drug delivery field and needs to be recognized .',
  'The patient with persistent foul drainage from a previously operated-on mastoid cavity has a serious problem that requires aggressive attention from the otologic surgeon .',
  'A case is represented as an illustration , that regardless of the big progress in the medical knowledge and the opportunities of the surgery technique nowadays , these complications continue to be a serious problem in the otorhinolaryngology and enforced close collaboration .',
  'Chronic suppurative otitis media ( CSOM ) is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions .',
  'Acute otitis media ( AOM ) is a serious public health problem and is considered one of the most common diagnoses in pediatric outpatient units .',
  'Cholesteatoma is a serious otolaryngologic condition that to date remains an important problem and poses a challenge to otolaryngologists around the world .',
  'The otorrhea forms a serious problem in 30 % of the VT that show drainage ; it is more frequent in younger children and in those with a history of recurrent otitis media , especially if they were associated with otorrhea .',
  'Ototoxicity is a serious and pervasive problem in this patient population .',
  'The unfavorable temporoauriculomastoid region is a serious clinical problem that makes total ear reconstruction a real challenge .'],
 'otoplasty': ['However , if the primary otoplasty technique is a cartilage-sculpting method , the efficiency of this technique remains unknown because no patient in this study had cartilage-sculpting otoplasty as primary otoplasty , which is possibly the main drawback of this study .',
  'Hypertrophic adenoids with otitis media with effusion is a common infectious disease and present a serious otological problem in children .',
  'Ototoxicity is a serious health problem that greatly affects millions of people worldwide .',
  'Serous otitis media : a serious problem .',
  'The treatment of cholesteatoma in patients without a permanent residence or in medically underdeveloped countries presents a serious problem in middle ear surgery .',
  'Unresolved otitis media ; a serious new problem .',
  'The extremely high prevalence of otitis media , in spite of sophisticated innate and adaptive immune systems , is a vexing problem for clinicians and scientists .',
  'Chronic suppurative otitis media is a serious health problem worldwide .',
  'Their ototoxicity is a serious health problem and , as their ototoxic mechanism involves the production of NO , we need to assess the use of NO inhibitors for the prevention of aminoglycoside-induced sensorineural hearing loss .',
  '[ Intracranial otogenic complications : inspite of therapeutic progress still a serious problem ] .',
  'In 10.4 % of the cases , otorrhea was noticed ; it formed a serious problem in 3.1 % of the ears .',
  'Non-tuberculous otomastoiditis is a severe ear disease with challenging considerations , and should be treated aggressively in order to avoid morbidity .',
  'Acute otitis media ( AOM ) is a serious health concern for millions of children .',
  'Otitis media can be a vexing , recurrent problem .',
  'The lack of precision in nomenclature is a serious problem for the inner ear drug delivery field and needs to be recognized .',
  'The patient with persistent foul drainage from a previously operated-on mastoid cavity has a serious problem that requires aggressive attention from the otologic surgeon .',
  'A case is represented as an illustration , that regardless of the big progress in the medical knowledge and the opportunities of the surgery technique nowadays , these complications continue to be a serious problem in the otorhinolaryngology and enforced close collaboration .',
  'Chronic suppurative otitis media ( CSOM ) is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions .',
  'Acute otitis media ( AOM ) is a serious public health problem and is considered one of the most common diagnoses in pediatric outpatient units .',
  'Cholesteatoma is a serious otolaryngologic condition that to date remains an important problem and poses a challenge to otolaryngologists around the world .',
  'The otorrhea forms a serious problem in 30 % of the VT that show drainage ; it is more frequent in younger children and in those with a history of recurrent otitis media , especially if they were associated with otorrhea .',
  'Ototoxicity is a serious and pervasive problem in this patient population .',
  'The unfavorable temporoauriculomastoid region is a serious clinical problem that makes total ear reconstruction a real challenge .'],
 'ototoxicity': ['However , if the primary otoplasty technique is a cartilage-sculpting method , the efficiency of this technique remains unknown because no patient in this study had cartilage-sculpting otoplasty as primary otoplasty , which is possibly the main drawback of this study .',
  'Hypertrophic adenoids with otitis media with effusion is a common infectious disease and present a serious otological problem in children .',
  'Ototoxicity is a serious health problem that greatly affects millions of people worldwide .',
  'Serous otitis media : a serious problem .',
  'The treatment of cholesteatoma in patients without a permanent residence or in medically underdeveloped countries presents a serious problem in middle ear surgery .',
  'Unresolved otitis media ; a serious new problem .',
  'The extremely high prevalence of otitis media , in spite of sophisticated innate and adaptive immune systems , is a vexing problem for clinicians and scientists .',
  'Chronic suppurative otitis media is a serious health problem worldwide .',
  'Their ototoxicity is a serious health problem and , as their ototoxic mechanism involves the production of NO , we need to assess the use of NO inhibitors for the prevention of aminoglycoside-induced sensorineural hearing loss .',
  '[ Intracranial otogenic complications : inspite of therapeutic progress still a serious problem ] .',
  'In 10.4 % of the cases , otorrhea was noticed ; it formed a serious problem in 3.1 % of the ears .',
  'Non-tuberculous otomastoiditis is a severe ear disease with challenging considerations , and should be treated aggressively in order to avoid morbidity .',
  'Acute otitis media ( AOM ) is a serious health concern for millions of children .',
  'Otitis media can be a vexing , recurrent problem .',
  'The lack of precision in nomenclature is a serious problem for the inner ear drug delivery field and needs to be recognized .',
  'The patient with persistent foul drainage from a previously operated-on mastoid cavity has a serious problem that requires aggressive attention from the otologic surgeon .',
  'A case is represented as an illustration , that regardless of the big progress in the medical knowledge and the opportunities of the surgery technique nowadays , these complications continue to be a serious problem in the otorhinolaryngology and enforced close collaboration .',
  'Chronic suppurative otitis media ( CSOM ) is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions .',
  'Acute otitis media ( AOM ) is a serious public health problem and is considered one of the most common diagnoses in pediatric outpatient units .',
  'Cholesteatoma is a serious otolaryngologic condition that to date remains an important problem and poses a challenge to otolaryngologists around the world .',
  'The otorrhea forms a serious problem in 30 % of the VT that show drainage ; it is more frequent in younger children and in those with a history of recurrent otitis media , especially if they were associated with otorrhea .',
  'Ototoxicity is a serious and pervasive problem in this patient population .',
  'The unfavorable temporoauriculomastoid region is a serious clinical problem that makes total ear reconstruction a real challenge .'],
 'arsenic': ['A drawback of As(III ) detection using square wave anodic stripping voltammetry ( SWASV ) is that it is susceptible to interferences from various metals or organic compounds , especially in real sample water .',
  'Arsenic ( As ) contamination is a severe problem in the intertidal zones of the Bohai Sea ( China ) with wide salinity variation .',
  'Arsenic poisoning from drinking groundwater is a serious problem , particularly in developing Asian countries .',
  'Arsenic in drinking water is a serious problem for human health .',
  'This is a serious global health problem because arsenic is a Group 1 ( proven ) human carcinogen and chronic exposure is known to cause skin , lung , and bladder tumors .',
  'Arsenic ( As ) contamination in soil and groundwater has become a serious problem to public health .',
  'Groundwater pollution by arsenic is a serious worldwide problem , especially in Asian countries .',
  'Phytotoxicity of aluminum ( Al ) has become a serious problem in inhibiting plant growth on acid soils .',
  'A severe reoccurrence of AR was found in 2 of the 10 AR problem farms .',
  'The deactivation of selective catalytic reduction ( SCR ) catalysts by arsenic is a serious problem for NH',
  'Arsenic ( As ) contamination of the environment has emerged as a serious problem .',
  'Arsenic , in drinking water is a serious concern .',
  'Arsenic pollution in soil has been a serious problem all over the world .',
  'Arsenic-contaminated drinking water is known to be a serious human health problem .',
  'Arsenic contamination of ground water has become a serious problem all over the world .',
  'Arsenic contamination in groundwater from crystalline basement rocks in West Africa has only been documented in isolated areas and presents a serious health threat in a region already facing multiple challenges related to water quality and scarcity .',
  'Phytotoxicity of aluminum ion ( Al3 + ) is a serious problem limiting crop production on acid soils .',
  'Arsenic in groundwater is a serious problem in New England , particularly for domestic well owners drawing water from bedrock aquifers .',
  'This study revealed that aluminum toxicity is a serious harmful problem for rice crop productivity in acid soil .',
  'A serious problem in extracting IAA from plant tissues is the considerable loss .',
  'Contamination of arsenic ( As ) in rice ( Oryza sativa L. ) paddies and subsequent uptake by rice plants is a serious concern , because rice is a staple crop for millions of people .',
  'Arsenic contamination in water bodies is a serious problem and causes various health problems due to which US Environment Protection Agency ( USEPA ) set its maximum permissible limit of 10 \xa0 ppb .',
  'Chronic exposure to arsenic is a serious problem to human health .',
  '• Strategies to reduce arsenic ( As ) in rice grain , below concentrations that represent a serious human health concern , require that the mechanisms of As accumulation within grain be established .',
  'Contamination of drinking water by arsenic and other heavy metals and their related toxicology is a serious concern now-a-days .',
  'The neurotoxicity of arsenic is a serious health problem , especially for children .',
  'Naturally occurring arsenic in groundwater in Cambodia is a serious health concern .',
  'Though , little is known about the effects of arsenical on leukemia resistant to chemotherapy , emerging as a serious clinical problem .',
  'In Morocco , acute aluminum phosphide poisoning ( AAlPP ) is a serious health care problem .',
  'Residual dissolved aluminum ( Al ) in drinking water is becoming a serious concern due to its high potential risks to human health .',
  'Arsenic contamination is a serious problem in rice cultivated soils of many developing countries .',
  'The toxicity of aluminium in dialysis patients was a serious problem for haemodialysis units in the seventies and eighties of the last century .',
  'Accumulation of arsenic in plants is a serious South-east Asian environmental problem .',
  "In this project , our goal was to assess Bangladeshi research participants ' attitudes towards receiving information regarding genetic susceptibility to the effects of consuming arsenic-contaminated drinking water , a serious environmental health concern in Bangladesh and other countries .",
  'Groundwater arsenic contamination has become a serious global concern due to its adverse effects on human health .',
  'Exposure to arsenic via drinking water is a serious health concern in the US .',
  'Arsenic contamination of drinking water is a serious water quality problem in many parts of the world .',
  'Arsenic ( As ) is naturally occurring toxic metalloid which is considered as a serious environmental and health concern .',
  'Water sources pollution by arsenic ions is a serious environmental problem all around the world .',
  'The extensive extraction of arsenic (As)-contaminated groundwaters for drinking , household and agricultural purposes represents a serious health concern in many districts of Bangladesh .',
  'Arsenic toxicity is a serious global health concern since over 200 million people are chronically exposed worldwide .',
  'Globally , arsenic contaminated groundwater is a serious concern for human health .',
  'Arsenicosis became a serious problem for the affected communities .',
  'Pollution of antimony ( Sb ) raises a serious environmental problem .',
  'Phenyl substituted arsenic compounds are widely used as feed additives in the poultry industry and have become a serious environmental concern .',
  'Elevated arsenic concentration in the environment and agricultural soil is a serious concern to crop production and human health .',
  'Arsenic exposure was a serious health problem in the region .',
  'Arsenic (As)-polluted groundwater constitutes a serious problem for peanut plants , as roots can accumulate the metalloid in their edible parts .',
  'The present data suggested that exposure to arsenic is associated with an increased prevalence of underweight , a serious health problem in developing countries , which in turn is associated with increased skin manifestation of arsenic poisoning .',
  'The contamination of arsenic in human drinking water supplies is a serious global health concern .',
  'High concentration of arsenic ( As ) in rice is a serious problem worldwide .',
  'Arsenic ( As ) contamination of rice grain is a serious problem worldwide .',
  'Arsenic created a serious public health problem in Bangladesh due to its presence in groundwater and dissemination of the toxic effects to millions of people .',
  'Exposure to arsenic and its compounds was a serious problem in one of the plants .',
  'Human exposure to drinking water contaminated with arsenic is a serious global health concern and it predisposes people to cardiovascular diseases , such as hypertension , atherosclerosis , and microvascular diseases .',
  'Arsenic contamination of the groundwater in the Hetao area in Inner Mongolia , China , has been a serious problem since the 1980s .',
  'Elevated Al concentration in water of this aquifer is described as a serious health concern when used for the household water supply .',
  'Arsenic pollution of groundwater is a serious problem in many regions of Latin America that causes severe risks to human health .',
  'In the Red River Delta , Vietnam , arsenic ( As ) contamination of groundwater is a serious problem where more than seventeen million people are affected .',
  'Arsenic concentrations of tubewell water that exceed acceptable limits poses a serious health problem in Bangladesh .',
  'Arsenic poisoning continues to be a serious medical problem that may easily be overlooked or misdiagnosed .',
  "Water contamination particularly ground water contamination with arsenic is a serious problem in today 's scenario since arsenic is associated with several kinds of health problems , such arsenic associated health anomalies are commonly called as ' Arsenism ' .",
  'Toxicity of aluminum ( Al ) is a serious problem for agricultural plants , especially due to excessive soil acidification caused by continuous intensive agriculture and modified environmental conditions related with global climate change .',
  'The presence of arsenic in drinking water has been a serious health problem in many countries .',
  'Arsenic exposure via drinking water is a serious environmental health concern .',
  'Arsenic ( As ) contamination of the groundwater in the Mekong Delta is a serious problem affecting millions of people who rely on this important resource for drinking and agriculture .',
  'The environmental contaminant arsenic causes cancer , developmental retardation , and other degenerative diseases and , thus , is a serious health concern worldwide .',
  'Arsenic contamination in soil is a serious problem affecting both site use and groundwater quality .',
  'Arsenic contamination of soil and groundwater is a serious problem worldwide .',
  'Arsenic trioxide ( arsenite , As(III ) ) has shown a remarkable clinical efficacy , whereas its side effects are still a serious concern .',
  'Arsenic is a toxic metalloid widely present in nature , and arsenic poisoning in drinking water is a serious global public problem .',
  'Arsenic ( As ) contamination of water is a serious problem in developing countries .',
  'The high toxicity of arsenic derivatives converts this element in a serious problem of public health worldwide .',
  'In India , acute aluminium phosphide poisoning ( AAlPP ) is a serious health care problem .',
  'Microbe-mediated redox transformation of arsenic ( As ) leading to its mobilization has become a serious environmental concern in various subsurface ecosystems especially within the alluvial aquifers .',
  'Loss of cognitive function due to arsenic exposure is a serious health concern in many parts of the world , including China .',
  'Studies have shown a significant form of toxic As ( III ) being released through the reductive dissolution of iron-oxy/hydroxide minerals and microbial reduction mechanisms , which leads to a serious health concern .',
  'Arsenic ( As ) pollution is a serious concern worldwide .',
  'Arsenic toxicity is a serious public health problem worldwide that brings more than 100 million people into the risk of arsenic exposure from groundwater and food contamination .',
  'Diabetes is a menacing problem , particularly to inhabitants of groundwater arsenic contaminated areas needing new medical approaches .',
  'Arsenic contamination has become a menacing health concern , warranting search for new drugs capable of ameliorating its toxicity .',
  'Chronic arsenic toxicity is a serious environmental health problem across the world .',
  'Soil contamination with co-existing arsenic ( As ) and antimony ( Sb ) has become a serious environmental problem worldwide .',
  'Arsenic ( As ) in rice grains is a serious food safety concern .',
  'The exposure of paddy fields to arsenic ( As ) through groundwater irrigation is a serious concern that may not only lead to As accumulation to unacceptable levels but also interfere with mineral nutrients in rice grains .',
  'Arsenic in drinking water presents a serious public health problem in Serbia , but its relationship with diabetes has not been studied previously .',
  'Arsenic contamination of groundwater is a serious concern worldwide .',
  'Arsenic ( As ) contamination has emerged as a serious public health concern worldwide because of its accumulation and mobility through the food chain .',
  'In recent years , the arsenic contamination of the herb and its relative products becomes a serious problem due to elevated soil As concentration .',
  'Arsenic contamination in groundwater is a severe global problem , most notably in Southeast Asia where millions suffer from acute and chronic arsenic poisoning .',
  'Soil arsenic ( As ) contamination is a serious concern because of its mark negative impacts on plant growth and physiological processes .',
  'Human exposure to drinking water contaminated with arsenic is a serious global health concern and predisposes to cardiovascular disease states , such as hypertension , atherosclerosis , and microvascular disease .',
  'Aluminum ( Al ) toxicity is a serious problem for rice crop productivity in acidic soils worldwide .',
  'The ubiquitous presence of arsenic ( a toxic metalloid ) in our environment , particularly in our drinking water , is a serious health hazard of global concern .'],
 'hcv': ['Type 1 interferons ( IFNs ) have been shown to be efficacious against hepatitis C virus ( HCV ) , hepatitis B virus ( HBV ) , and some cancers with a significant drawback of short drug exposure .',
  'Hepatitis C virus ( HCV ) is a serious global problem , and present therapeutics are inadequate to cure HCV infection .',
  'Chronic hepatitis C virus infection represents a serious global public health problem , typically resulting in fibrosis , cirrhosis , and ultimately hepatocellular carcinoma .',
  'Recurrent hepatocellular carcinoma after living donor liver transplantation : a preventable problem or an acceptable risk ?',
  'Hepatitis C virus ( HCV ) infection remains a serious health problem worldwide .',
  'US participants reported higher levels of knowledge of IPV , were more likely to believe that IPV was a serious problem , and were more likely to consider IPV to be a healthcare problem compared with Vietnamese and Chinese participants .',
  'HCV infected patients and healthy subjects were selected from the expatriate Egyptian population living in Qatar , where chronic HCV infection poses a serious health problem .',
  'Abstract Hepatitis C virus ( HCV ) infection is a serious health problem worldwide that can lead to hepatocellular carcinoma or end-stage liver disease .',
  'Interferon (IFN)-alpha is regarded as an efficient therapy for chronic hepatitis C , despite the fact that less than 50 % of patients receiving IFN-alpha are known to show an initial biochemical response , and several adverse reactions related to this therapy are becoming a serious clinical problem .',
  'Graft loss because of hepatitis C virus recurrence is a serious problem after liver transplantation ( LT ) , and the response to pegylated interferon ( PEG-IFN ) and ribavirin ( RBV ) is poor .',
  'Currently , hepatitis C virus ( HCV ) infection is considered a serious health-care problem all over the world .',
  'Hepatitis C virus ( HCV ) infection is a serious public health problem , since 80 % to 85 % of HCV carriers develop a persistent infection that can progress into liver cirrhosis and hepatocarcinoma .',
  'Hepatitis C represents a serious worldwide health-care problem .',
  'Care-associated HCV infections represented a huge part of hepatitis C burden in the past via contaminated blood and unsafe injections and continue to be a serious problem of public health .',
  'While a test for multiple antibodies is thought to be effective for the screening of HCV , more blood needs to be discarded , having a serious cost-performance problem .',
  'Hepatitis C virus ( HCV ) infection represents a serious health-care problem .',
  'Especially the chronic form of hepatitis C ( HC ) , with 55 - 85 % of acute cases progressing to it , is a serious problem worldwide .',
  'However , a small proportion of patients persistently infected with HCV , in whom anti-HCV are undetectable , constitute a serious diagnostic and possibly epidemiologic problem , as they could facilitate pathogen spread in the population .',
  'The chronic infection by the hepatits C virus represents a serious sanitary problem affecting 1 - 3 % of the world-wide population .',
  'Graft loss due to hepatitis C ( HCV ) recurrence is a serious problem after LT .',
  'Hepatitis C virus ( HCV ) recurrence after orthotopic liver transplantation ( OLT ) remains a serious problem in the clinical management of post-oLT patients .',
  'Hepatitis C virus infection among maintenance hemodialysis patients : a preventable problem of the world .',
  'Hepatitis C virus ( HCV ) infection is a serious problem among those co-infected with human immunodeficiency virus ; however , its impact in the central nervous system ( CNS ) remains unclear .',
  'We conclude that HCV infection is a serious health problem among kidney transplant recipients and it significantly affects the graft outcome .',
  'HCV is a serious public health concern , and if IDU are to be encouraged into drug treatment it is essential that service providers are perceived to be non-discriminatory .',
  'Hepatitis C virus ( HCV ) genotype 3a infection poses a serious health problem worldwide .',
  'Hepatitis C virus infection constitutes a serious health problem in need of more effective therapies .',
  'Hepatitis C virus ( HCV ) infection has become a severe health problem worldwide .',
  'Hepatitis C virus ( HCV ) infection represents a serious health problem .',
  'Hepatitis C virus ( HCV ) is a serious global health problem affecting approximately 130 - 150 million individuals .',
  'On account of the asymptomatic course , no possibility to prevent by vaccination and \n the serious consequences of long-term infection ( liver cirrhosis , hepatocellular carcinoma ) , hepatitis C ( HCV \n infection ) is a serious public health problem .',
  'Hepatitis C virus ( HCV ) infection is a serious and rising global healthcare problem .',
  'Hepatitis C virus ( HCV ) infection is a serious health problem in New York City .',
  'Hepatitis C virus ( HCV ) infection is a serious problem worldwide .',
  'The detection of HCC in cirrhotic patients with BEV remains a serious , unsolved problem .',
  'Viral hepatitis C is a serious public health problem in France by the number of infected patients , the evolutive profile and by the lack of fully efficient therapeutics .',
  'Hepatitis C is emerging as a serious worldwide problem .',
  'Hepatitis C virus ( HCV ) infection is a serious problem worldwide , but no effective drugs are currently available .',
  'Hepatitis C virus ( HCV ) infection is a serious public health concern throughout the world .',
  'Hepatitis C is a serious public health problem with more than 170 million chronic carriers worldwide .',
  'Although more than 80 per cent of the study group had heard of hepatitis C , only 50 per cent considered the infection to be a serious problem .',
  'Hepatitis C virus ( HCV ) infection one of the most common blood-borne infections is endemic in Cameroon and a serious problem in hemodialysis ( HD ) .',
  'Infection with hepatitis C virus ( HCV ) is a serious public health problem worldwide .',
  'With over 170 million individuals chronically infected with hepatitis C virus ( HCV ) worldwide , HCV is currently a serious global health concern , leading to chronic hepatitis , cirrhosis and HCC , thereby causing significant morbidity and mortality .',
  'Acute and chronic hepatitis C virus ( HCV ) infection remains a serious health problem worldwide , however , there has been advancement in the treatment of HCV infection due to standard treatment using pegylated interferon and ribavirin .',
  'However , since no vaccine exists for hepatitis C and the increased chances for the development of chronic infection hepatitis C will remain a serious health concern .',
  'From the epidemiological point of view the HIV-1 prevalence is decreasing ; hepatitis C turned out to be a serious medical problem for IVDA .',
  'Hepatitis C is a serious problem on the Greek island of Crete , where a high prevalence of antibodies against hepatitis C ( anti-HCV ) has recently been reported .',
  'Chronic hepatitis C is a serious global medical problem necessitating effective treatment .',
  'Hepatitis B ( HBV ) and C ( HCV ) infections are a serious global and national public health problem .',
  'Hepatitis C virus ( HCV ) infection is a serious and significant global health problem in the Pakistan and elsewhere .',
  'HCV is a serious public health concern requiring screening , education , reduction of disease transmission , and access to care .',
  'In the liver transplant ( LT ) setting , these regimens are expected to have an important effect , because graft loss due to HCV recurrence is a serious problem after LT .',
  'Chronic hepatitis C virus ( HCV ) infection is a serious global health problem affecting 150 million individuals worldwide .',
  'HCV virus infections have become a serious epidemiological problem throughout the world .',
  'Hepatitis C : a serious public health concern .',
  'Chronic hepatitis C virus ( HCV ) infection is a serious public health problem worldwide .',
  'Hepatitis C virus ( HCV ) is a serious public health problem affecting 170 million carriers worldwide .',
  'Hepatitis C virus ( HCV ) infection is a serious public health problem throughout the world .',
  'Human immunodeficiency virus (HIV)/hepatitis C virus ( HCV ) coinfection has become a serious public health problem .',
  'Infection with hepatitis C virus ( HCV ) is still a serious problem in hemodialysis patients , despite screening of blood products for anti-HCV antibodies .',
  'Individual factors included the perception that untreated HCV infection was not a serious health concern , family responsibilities , and self-perceived discrimination against HCV-infected women .',
  'Hepatitis C is a serious public health problem throughout the world ; chronic renal patients are highly exposed to this infection .',
  'Hepatitis C virus ( HCV ) infection is a serious health problem in Georgia .',
  'The hepatitis C virus ( HCV ) is globally recognized as a serious public health concern .',
  'Hepatitis C virus ( HCV ) represents a serious public health concern .',
  'Resistance to antiviral therapy remains a serious problem in the management of chronic hepatitis C. In most patients , HCV RNA could be detected in peripheral blood mononuclear cell ( PBMC ) .',
  'Hepatitis C virus ( HCV ) infection is considered by the World Health Organization ( WHO ) to be a serious public health concern and one of the major public health priorities .',
  'Recurrent hepatitis C infection in the posttransplant setting is a serious problem .',
  'Hepatitis C virus ( HCV ) infection is a serious global health problem .',
  'HCV infection is a serious public health problem and a leading cause of chronic liver disease .',
  'Hepatitis B virus and Hepatitis C virus infections are among the most common viral infections globally and maintain their position as a serious public health problem .',
  'Hepatitis C virus ( HCV ) infections are a serious viral health problem globally , causing liver cirrhosis and inflammation that can develop to hepatocellular carcinoma and death .',
  'Currently , hepatitis C is a serious public health problem .',
  'Hepatitis C virus ( HCV ) is a serious global health problem which accounts for approximately 40 % of chronic liver diseases worldwide .',
  'Hepatitis C virus ( HCV ) recurrence is a serious problem after orthotopic liver transplantation ( OLT ) .',
  'Hepatitis C virus ( HCV ) recurrence after liver transplantation ( LT ) used to be a serious problem in the era of interferon-based treatment .',
  'Hepatitis C virus ( HCV ) represents a serious worldwide healthcare problem .',
  'Chronic hepatitis C ( CHC ) is a serious clinical problem .',
  'Despite its significantly higher prevalence , hepatitis C , now a serious public health problem , has long been overshadowed by HIV infection in France .',
  'Hepatitis C virus ( HCV ) infection is a serious health problem world-wide .',
  'Hepatitis C virus ( HCV ) infection is a serious global health problem .',
  'Persistent hepatitis C virus ( HCV ) infection causes chronic liver diseases and is a serious global health problem .',
  'The global epidemic of hepatitis B and hepatitis C is a serious publichealth problem .',
  'Hepatitis C virus (HCV)/human immunodeficiency virus ( HIV ) co-infection has become a serious public health problem especially in high risk groups such as injection drug users in China .',
  'Non-A , non-B ( type C ) hepatitis is a serious world problem which typically results in chronic hepatitis and may lead to cirrhosis and hepatocellular carcinoma .',
  'However , the recurrence of HCC after transplantation remains a serious problem that affects about 20 % of post-transplant cases .',
  'Infections by HCV represent a serious global health problem , because millions of people worldwide are infected and no efficient treatment is available at the present time .',
  'Hepatitis C virus ( HCV ) infection is a serious public health problem because of its worldwide diffusion and sequelae .',
  'It imposes a serious problem to public health in the world as the population of chronically infected HCV patients who are at risk of progressive liver disease is projected to increase significantly in the next decades .',
  'Hepatitis C is a disease that constitutes a serious global health problem , is often asymptomatic and difficult to diagnose and about 60 - 80 % of infected patients develop chronic diseases over time .',
  'Hepatitis C virus ( HCV ) infection is a serious global health problem , with 3 - 4 million new cases reported each year .',
  "Hepatitis C Virus ( HCV ) is a serious global health problem , infecting almost 3 % of the world 's population .",
  'Hepatitis C virus ( HCV ) remains a serious global health problem that lacks an effective cure .',
  'Hepatitis C virus ( HCV ) infection is a serious public health problem .',
  'Chronic hepatitis C virus ( HCV ) infection is a serious health problem in Taiwan .',
  'Hepatitis C virus ( HCV ) infection represents a serious public health problem worldwide .',
  'Hepatitis B , hepatitis C , and HIV infections are a serious global and public health problem .',
  'Hepatitis C virus ( HCV ) infection is a serious public health problem , that affects approximately 170 million people worldwide .',
  'In North African countries , HCV seems to be a serious problem that is driven by different vectors even in different geographical locations within the same country .',
  'Hepatitis C recurrence after liver transplantation is a serious problem , leading to increased graft loss and morbidity in some individuals .',
  'Hepatitis C virus infection is a serious public health problem .',
  'Hepatitis C virus ( HCV ) infection remains a serious public health problem worldwide .',
  'Hepatitis C virus ( HCV ) , the major etiological agent of transfusion-associated non-A , non-B hepatitis , is a severe health problem affecting up to 3 % of the world population .',
  "Chronic infection with hepatitis C virus ( HCV ) is a serious public health problem affecting an estimated 2 % of the world 's population .",
  'Hepatitis C virus ( HCV ) is a serious global health problem and establishes chronic infection in a significant number of infected humans worldwide .',
  'Infection by hepatitis C viruses ( HCVs ) is a serious medical problem with no broadly effective treatment available for the progression of chronic hepatitis .',
  'Drug resistance remains a serious problem that limits the effectiveness of US Food and Drug Administration (FDA)-approved direct-acting antiviral ( DAA ) drugs against HCV proteins .',
  'Hepatitis C virus ( HCV ) infection is a serious health problem leading to cirrhosis , liver failure and hepatocellular carcinoma .',
  'Chronic hepatitis C infection is a serious therapeutic problem .',
  'Among patients with renal insufficiency undergoing chronic dialysis treatment , chronic hepatitis due to infection with viruses of the hepatitis B ( HBV ) or hepatitis C ( HCV ) type represents a serious medical problem .',
  'Hepatitis C virus (HCV)-mediated chronic liver disease is a serious health problem around the world and often causes fibrosis/cirrhosis and hepatocellular carcinoma .',
  'Chronic hepatitis C ( CHC ) is a serious medical problem necessitating more effective treatment .',
  'Chronic hepatitis C ( HCV ) infection is a serious problem all over the world and has a special importance in Egypt , where the prevalence of infection is 14.7 % of population .',
  'Infection with hepatitis C virus is a serious worldwide health problem .',
  'Hepatitis C ( HCV ) viral infection is a serious medical problem in Egypt and it has a devastating impact on the Egyptian economy .',
  'Hepatitis C virus ( HCV ) infections are a serious global-scaled public health problem .',
  'Hepatitis C virus ( HCV ) infections caused by occupational percutaneous injuries are a serious problem for healthcare workers and there has been a gradual increase in the number of HCV infections .',
  'HCV ( hepatitis C virus ) infection is a serious health care problem that affects more than 170 million people worldwide .',
  'Infections with Hepatitis C virus ( HCV ) pose a serious health problem worldwide .',
  'The hepatitis C is a severe public health problem worldwide because its consequences .',
  'Recurrent hepatitis C after liver transplantation is a serious problem faced by liver transplant recipients .',
  'Recurrent hepatitis C virus ( HCV ) has been a serious problem after liver transplantation ( LT ) .',
  'Hepatitis B virus ( HBV ) and hepatitis C virus ( HCV ) infections are a serious global public health problem affecting billions of people .'],
 'milk': ['A major drawback of using dairy slurry as fertilizer is that it may contains pathogens such as Mycobacterium avium subsp . paratuberculosis ( MAP ) , and it could represent a risk to animal and public health .',
  'The use of OTC has become a serious problem because of the possible existence of its residues in milk , which can be directly toxic or cause allergic reactions in some hypersensitive individuals .',
  'Melamine adulteration in milk is a serious health concern for the consumers .',
  'The dioxin intake from commercial baby food is considered not to be a serious problem at the moment .',
  'The presence of pathogenic bacteria poses a serious problem in sustaining the safety of dairy products .',
  'Lactose intolerance , a serious health problem for Asians , can be solved using probiotic bacteria having high lactose hydrolysis activities .',
  'As demand for milk-derived products is increasing , it leads to increased production of whey , which poses a serious management problem .',
  'The results showed that AFM1 contamination is a serious problem for public health .',
  'Milk proteolysis caused by Pseudomonas fluorescens is a serious problem in the dairy industries as a result of its ability to grow under refrigeration .',
  'Milk antimicrobial residues are a serious concern for the dairy industry .',
  'Bacteriophage infection in dairy fermentation constitutes a serious problem worldwide .',
  'Human error often becomes a serious problem in dairy life .',
  'Thermal stable proteases may constitute a serious problem to ultra-high temperature ( UHT ) processed milk , leading to undesirable physical and sensory alterations .',
  'The results indicated that the contamination of the samples with AFM1 in such a level could be a serious public health problem at the moment .',
  'The results indicate a serious problem in the use of some assays that were designed to evaluate residues bulk tank milk samples to analyze samples from individual cows .',
  'The levels ofAFM1 in total samples indicated that feeds for cows in this region were contaminated with AFB1 in such a level that appears to be a serious public health problem at the moment .',
  'Contaminants in infant foods and human breast milk were highlighted in this paper as a serious problem as they can pose a potential hazard for infants .',
  'Lactose intolerance is a serious global health problem .',
  'Contaminations of these feeds by AFs and its possible transmission into edible materials like milk , egg and organs of the body , are a serious problem .',
  'Light-induced degradation reactions in milk create a serious problem for the dairy industry because of the development of off-flavors , the decrease in nutritional quality , and the severity and speed by which these phenomena develop .',
  'AFs tend to contaminate a wide range of foods which is a serious and recurring food safety problem worldwide .',
  'Udder infections with environmental pathogens like Escherichia coli are a serious problem for the dairy industry .',
  'These results show the necessity of a survey involving a larger number of milk and its products and suggest that presently the contamination of milk and milk products with AFM1 does not appear to be a serious health problem in Kuwait .',
  'This poses a serious problem for the US dairy industry .',
  'It can be concluded that AFM1 levels in the samples purchased in Central Anatolia Region , appear to be a serious public health problem at the moment .',
  'Antibiotic residues in milk are a serious health and technological problem in dairy processes .',
  'Because yoghurt is the most popular dairy product consumed in Iran , the AFM(1 ) contamination is a serious problem for public health .',
  'These findings should raise a serious public health concern considering the extent to which the communities of the study areas are in contact with their animals and the levels at which they use untreated milk .',
  'represent a serious problem in the dairy industry as they can cause spoilage of milk and dairy products .',
  "Development of a prediction model for a severe reaction in cow 's milk challenges ."],
 'dairy': ['A major drawback of using dairy slurry as fertilizer is that it may contains pathogens such as Mycobacterium avium subsp . paratuberculosis ( MAP ) , and it could represent a risk to animal and public health .',
  'Intramammary infections are a serious problem for dairy sheep farms , and Staphylococcus epidermidis is one of the main etiological agents of ovine mastitis .',
  'Bovine mastitis caused by Prototheca is a serious and complex problem that accounts for high economic losses in the dairy industry .',
  'The use of OTC has become a serious problem because of the possible existence of its residues in milk , which can be directly toxic or cause allergic reactions in some hypersensitive individuals .',
  'Melamine adulteration in milk is a serious health concern for the consumers .',
  'The trial showed that the vaccine was efficacious in reducing the incidence of clinical mastitis and prevalence of subclinical mastitis in a herd that had a serious staphylococcal mastitis problem .',
  'Mastitis is a serious problem in dairy sector and among various aetiological agents , the incidence of staphylococci and streptococci remains high in milking animal .',
  'The dioxin intake from commercial baby food is considered not to be a serious problem at the moment .',
  'The presence of pathogenic bacteria poses a serious problem in sustaining the safety of dairy products .',
  'Lactose intolerance , a serious health problem for Asians , can be solved using probiotic bacteria having high lactose hydrolysis activities .',
  'Endometritis in dairy cow herds is a serious economic problem all over the world due to the large economic losses .',
  'The authors feel strongly that this work identifies a serious and ill-defined problem in the management of neonatal calves .',
  'Mastitis is a severe problem in humans and other animals and is characterized by mammary gland cell apoptosis .',
  'Oxidative stress in the mammary gland of high-yielding dairy cows is a serious problem .',
  'As demand for milk-derived products is increasing , it leads to increased production of whey , which poses a serious management problem .',
  'Mastitis , either subclinical or clinical , did not appear to be a serious problem in this particular flock .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) poses a serious problem in dairy animals suffering from mastitis .',
  'The results showed that AFM1 contamination is a serious problem for public health .',
  'A severe mastitis problem associated with Cryptococcus neoformans in a large dairy herd .',
  'Herds had been participating for 15 or 22 yr in mastitis control programs against Streptococcus agalactiae and Staphylococcus aureus , had low bulk tank SCC , and had maintained good standards of hygiene and husbandry , but clinical mastitis remained a serious problem .',
  'Sheep of four flocks ( group A ) , in which insufficient lamb growth apparently associated with insufficient milk production and probably related to udder induration , was a serious problem , were clinically examined in mid-lactation .',
  'Coliform mastitis ( CM ) is not only a serious economical and animal welfare touching problem in dairy cattle , but also in sows after farrowing .',
  'Colic in camelids is considered a severe problem because clinical signs are subtle and often not recognized until the condition is untreatable .',
  'Milk proteolysis caused by Pseudomonas fluorescens is a serious problem in the dairy industries as a result of its ability to grow under refrigeration .',
  'E. coli mastitis can be a severe problem during the beginning of lactation whereas it is completely self-curing after peak lactation ( 8 weeks ) .',
  'Digital dermatitis is a serious problem in dairy production in many countries .',
  'Milk antimicrobial residues are a serious concern for the dairy industry .',
  'Bacteriophage infection in dairy fermentation constitutes a serious problem worldwide .',
  'Poor udder health represents a serious problem in dairy production and has been investigated intensively , but heifers generally have not been the main focus of mastitis control .',
  'Human error often becomes a serious problem in dairy life .',
  'Reproductive diseases after parturition are a serious problem in dairy cattle .',
  'Thermal stable proteases may constitute a serious problem to ultra-high temperature ( UHT ) processed milk , leading to undesirable physical and sensory alterations .',
  'The results indicated that the contamination of the samples with AFM1 in such a level could be a serious public health problem at the moment .',
  'The results indicate a serious problem in the use of some assays that were designed to evaluate residues bulk tank milk samples to analyze samples from individual cows .',
  'The present data suggest that the effects of calf breed do not place a serious problem on the economic traits of Holstein dams .',
  'The incidence of attacking or avoiding calves is greater among heifers than among older cows and rejection is occasionally a serious problem .',
  'The levels ofAFM1 in total samples indicated that feeds for cows in this region were contaminated with AFB1 in such a level that appears to be a serious public health problem at the moment .',
  'Bovine mastitis caused by Staphylococcus aureus is a serious problem in dairy production and effective immunoprophylaxis is an unmet goal so far .',
  'Mastitis is a serious problem for sheep and rabbit farms , Staphylococcus aureus being the main causal agent .',
  'Contaminants in infant foods and human breast milk were highlighted in this paper as a serious problem as they can pose a potential hazard for infants .',
  'Lactose intolerance is a serious global health problem .',
  'Contaminations of these feeds by AFs and its possible transmission into edible materials like milk , egg and organs of the body , are a serious problem .',
  'Light-induced degradation reactions in milk create a serious problem for the dairy industry because of the development of off-flavors , the decrease in nutritional quality , and the severity and speed by which these phenomena develop .',
  'Pyometra is a serious problem in dairy cow herds , causing large economic losses due to infertility .',
  'AFs tend to contaminate a wide range of foods which is a serious and recurring food safety problem worldwide .',
  'Mastitis is an important animal health disease which constitutes a serious problem for the dairy industry in New Zealand .',
  'Udder infections with environmental pathogens like Escherichia coli are a serious problem for the dairy industry .',
  'In dairy cow herds , mastitis is a serious problem .',
  'These results show the necessity of a survey involving a larger number of milk and its products and suggest that presently the contamination of milk and milk products with AFM1 does not appear to be a serious health problem in Kuwait .',
  'This poses a serious problem for the US dairy industry .',
  'It can be concluded that AFM1 levels in the samples purchased in Central Anatolia Region , appear to be a serious public health problem at the moment .',
  'Uterine torsion appears to be a serious problem in buffaloes that has certain peculiarities including time of occurrence , site and direction of torsion , and the high mortality rates .',
  'Mastitis poses a serious problem for humans and animals in the postpartum period .',
  'Antibiotic residues in milk are a serious health and technological problem in dairy processes .',
  'Bovine digital dermatitis ( DD ) is a severe infectious disease causing lameness in dairy cattle worldwide and is an important ruminant welfare problem that has considerable economic issues .',
  'Because yoghurt is the most popular dairy product consumed in Iran , the AFM(1 ) contamination is a serious problem for public health .',
  'The detection of mastitis caused by Prototheca sp. indicates a serious problem which can affect an entire herd .',
  'Bovine mastitis caused by the yeast-like alga Prototheca zopfii represents a serious veterinary problem and may result in heavy economic losses to particular dairy farms .',
  'These findings should raise a serious public health concern considering the extent to which the communities of the study areas are in contact with their animals and the levels at which they use untreated milk .',
  'represent a serious problem in the dairy industry as they can cause spoilage of milk and dairy products .',
  "Development of a prediction model for a severe reaction in cow 's milk challenges .",
  'Calf mortality generally occurs in calves prior to weaning , which is a serious problem in cattle breeding .',
  'Hormone treatment promotes calving ease with a markedly reduced incidence of the detrimental effects of dystocia , which may be a serious problem in first-calf heifers .'],
 'sludge': ['Further improvements can only be applied by a chemical precipitation , with the drawback of increasing the wastewater disposal cost up to 6.5 \xa0 euros \xa0 CAP',
  'The accumulation of BPC in the SMBR sludge mixture would facilitate the formation of a sludge fouling layer on the membrane surface , thus causing a serious fouling problem .',
  'The huge volume of sludge emanating from the tannery effluent treatment plants poses a serious environmental problem .',
  'Organic wastes , such as the organic fractions of municipal solid waste ( OFMSW ) or sewage sludge ( SS ) , have become a serious environmental problem in Russia as well as in other countries .',
  'Massively produced sewage sludge brings a serious problem to environment .',
  'Sea sludge , which is sediment of fish excrement and sewage on the sea bottom , continues to be a serious environmental problem .',
  'Molasses is a wildly used feedstock for fermentation , but it also poses a severe wastewater-disposal problem worldwide .',
  'Phytoremediation technologies generate huge quantities of biomass , the disposal of which is a serious concern .',
  'Sago industries effluent containing large amounts of organic content produced excess sludge which is a serious problem in wastewater treatment .',
  'Disposal of tons of sludge produced daily by sewage treatment plants in large cities is a serious problem .',
  'The excessive growth of filamentous bacteria and the resultant bulking of activated sludge constitute a serious problem in numerous wastewater treatment plants .',
  'Even though treated effluent water from wastewater treatment plants are utilized for irrigation , disposal of sewage sludge is becoming a serious problem .',
  'Sewage sludge is a serious problem facing modern wastewater treatment plants .',
  'This review aims to provide a critical overview regarding the deactivation of sludge-associated pathogens by AD , through which a serious concern on the effectiveness and rationality of AD towards sludge pathogens control was raised .',
  'With increasing construction of wastewater treatment plants and stricter policies , municipal sewage sludge ( MSS ) disposal has become a serious problem .',
  'The calcification of Anaerobic Granular Sludge is a serious problem in the application of anaerobic methanization biotechnology .',
  'Ultimate disposal of the sludge or the adsorbate , however , is a serious problem .',
  'Therefore , this by-product of activated sludge process ( ASP ) presents a serious environmental problem .',
  'As a result of the wide application and utilization of the waste activated sludge process , excess sludge presents a serious disposal problem .',
  'Paper mill sludges are produced in large amounts and their disposal is a serious environmental problem .',
  'The disposal of excess sludge from wastewater treatment plants is a serious problem that needs to be addressed .',
  'Excess sludge production from wastewater treatment plants has significantly increased , and sludge disposal has become a serious social and environmental problem .',
  'Million tons of sewage sludge produced yearly creates a severe pollution problem to environment , and thus needs either to be properly disposed of , or recovered .',
  'Filamentous bulking sludge due to excessive growth of filamentous bacteria is a serious operational problem in activated sludge plants .',
  'Removal of sludges from Wastewater Treatment Plants ( WWTP ) represents a serious worldwide environmental problem for which alternatives other than their simple incineration are investigated .',
  'Large filamentous populations were present in about 60 % of the plants , which means that bulking of activated sludge , which is no longer a serious problem in modern domestic nutrient removal plants , still occurs frequently in industrial treatment plants .',
  'Settling problems caused by pin-point sludge constitute a serious problem in biological wastewater treatment , particularly in many industrial plants .',
  'Sewage sludge is a serious problem due to the high treatment costs and the risks to environment and human health .',
  'The current practice of the illegal dumping of solid waste on the river banks has created a serious environmental and public health problem .'],
 'sewage': ['Further improvements can only be applied by a chemical precipitation , with the drawback of increasing the wastewater disposal cost up to 6.5 \xa0 euros \xa0 CAP',
  'The accumulation of BPC in the SMBR sludge mixture would facilitate the formation of a sludge fouling layer on the membrane surface , thus causing a serious fouling problem .',
  'The huge volume of sludge emanating from the tannery effluent treatment plants poses a serious environmental problem .',
  'Organic wastes , such as the organic fractions of municipal solid waste ( OFMSW ) or sewage sludge ( SS ) , have become a serious environmental problem in Russia as well as in other countries .',
  'Massively produced sewage sludge brings a serious problem to environment .',
  'Sea sludge , which is sediment of fish excrement and sewage on the sea bottom , continues to be a serious environmental problem .',
  'Molasses is a wildly used feedstock for fermentation , but it also poses a severe wastewater-disposal problem worldwide .',
  'Phytoremediation technologies generate huge quantities of biomass , the disposal of which is a serious concern .',
  'Sago industries effluent containing large amounts of organic content produced excess sludge which is a serious problem in wastewater treatment .',
  'Disposal of tons of sludge produced daily by sewage treatment plants in large cities is a serious problem .',
  'The excessive growth of filamentous bacteria and the resultant bulking of activated sludge constitute a serious problem in numerous wastewater treatment plants .',
  'Even though treated effluent water from wastewater treatment plants are utilized for irrigation , disposal of sewage sludge is becoming a serious problem .',
  'Sewage sludge is a serious problem facing modern wastewater treatment plants .',
  'This review aims to provide a critical overview regarding the deactivation of sludge-associated pathogens by AD , through which a serious concern on the effectiveness and rationality of AD towards sludge pathogens control was raised .',
  'With increasing construction of wastewater treatment plants and stricter policies , municipal sewage sludge ( MSS ) disposal has become a serious problem .',
  'The calcification of Anaerobic Granular Sludge is a serious problem in the application of anaerobic methanization biotechnology .',
  'Ultimate disposal of the sludge or the adsorbate , however , is a serious problem .',
  'Therefore , this by-product of activated sludge process ( ASP ) presents a serious environmental problem .',
  'As a result of the wide application and utilization of the waste activated sludge process , excess sludge presents a serious disposal problem .',
  'Paper mill sludges are produced in large amounts and their disposal is a serious environmental problem .',
  'The disposal of excess sludge from wastewater treatment plants is a serious problem that needs to be addressed .',
  'Excess sludge production from wastewater treatment plants has significantly increased , and sludge disposal has become a serious social and environmental problem .',
  'Million tons of sewage sludge produced yearly creates a severe pollution problem to environment , and thus needs either to be properly disposed of , or recovered .',
  'Filamentous bulking sludge due to excessive growth of filamentous bacteria is a serious operational problem in activated sludge plants .',
  'Removal of sludges from Wastewater Treatment Plants ( WWTP ) represents a serious worldwide environmental problem for which alternatives other than their simple incineration are investigated .',
  'Large filamentous populations were present in about 60 % of the plants , which means that bulking of activated sludge , which is no longer a serious problem in modern domestic nutrient removal plants , still occurs frequently in industrial treatment plants .',
  'Settling problems caused by pin-point sludge constitute a serious problem in biological wastewater treatment , particularly in many industrial plants .',
  'Sewage sludge is a serious problem due to the high treatment costs and the risks to environment and human health .',
  'The current practice of the illegal dumping of solid waste on the river banks has created a serious environmental and public health problem .'],
 'wastewater': ['Further improvements can only be applied by a chemical precipitation , with the drawback of increasing the wastewater disposal cost up to 6.5 \xa0 euros \xa0 CAP',
  'The accumulation of BPC in the SMBR sludge mixture would facilitate the formation of a sludge fouling layer on the membrane surface , thus causing a serious fouling problem .',
  'The huge volume of sludge emanating from the tannery effluent treatment plants poses a serious environmental problem .',
  'Organic wastes , such as the organic fractions of municipal solid waste ( OFMSW ) or sewage sludge ( SS ) , have become a serious environmental problem in Russia as well as in other countries .',
  'Massively produced sewage sludge brings a serious problem to environment .',
  'Sea sludge , which is sediment of fish excrement and sewage on the sea bottom , continues to be a serious environmental problem .',
  'Molasses is a wildly used feedstock for fermentation , but it also poses a severe wastewater-disposal problem worldwide .',
  'Phytoremediation technologies generate huge quantities of biomass , the disposal of which is a serious concern .',
  'Sago industries effluent containing large amounts of organic content produced excess sludge which is a serious problem in wastewater treatment .',
  'Disposal of tons of sludge produced daily by sewage treatment plants in large cities is a serious problem .',
  'The excessive growth of filamentous bacteria and the resultant bulking of activated sludge constitute a serious problem in numerous wastewater treatment plants .',
  'Even though treated effluent water from wastewater treatment plants are utilized for irrigation , disposal of sewage sludge is becoming a serious problem .',
  'Sewage sludge is a serious problem facing modern wastewater treatment plants .',
  'This review aims to provide a critical overview regarding the deactivation of sludge-associated pathogens by AD , through which a serious concern on the effectiveness and rationality of AD towards sludge pathogens control was raised .',
  'With increasing construction of wastewater treatment plants and stricter policies , municipal sewage sludge ( MSS ) disposal has become a serious problem .',
  'The calcification of Anaerobic Granular Sludge is a serious problem in the application of anaerobic methanization biotechnology .',
  'Ultimate disposal of the sludge or the adsorbate , however , is a serious problem .',
  'Therefore , this by-product of activated sludge process ( ASP ) presents a serious environmental problem .',
  'As a result of the wide application and utilization of the waste activated sludge process , excess sludge presents a serious disposal problem .',
  'Paper mill sludges are produced in large amounts and their disposal is a serious environmental problem .',
  'The disposal of excess sludge from wastewater treatment plants is a serious problem that needs to be addressed .',
  'Excess sludge production from wastewater treatment plants has significantly increased , and sludge disposal has become a serious social and environmental problem .',
  'Million tons of sewage sludge produced yearly creates a severe pollution problem to environment , and thus needs either to be properly disposed of , or recovered .',
  'Filamentous bulking sludge due to excessive growth of filamentous bacteria is a serious operational problem in activated sludge plants .',
  'Removal of sludges from Wastewater Treatment Plants ( WWTP ) represents a serious worldwide environmental problem for which alternatives other than their simple incineration are investigated .',
  'Large filamentous populations were present in about 60 % of the plants , which means that bulking of activated sludge , which is no longer a serious problem in modern domestic nutrient removal plants , still occurs frequently in industrial treatment plants .',
  'Settling problems caused by pin-point sludge constitute a serious problem in biological wastewater treatment , particularly in many industrial plants .',
  'Sewage sludge is a serious problem due to the high treatment costs and the risks to environment and human health .',
  'The current practice of the illegal dumping of solid waste on the river banks has created a serious environmental and public health problem .'],
 'nsaids': ['Gastrointestinal ( GI ) toxicity is a major drawback of the chronic use of nonsteroidal anti-inflammatory drugs ( NSAIDs ) .',
  'NSAID gastropathy is a serious , iatrogenic problem of common NSAID usage of major public health dimensions .',
  'Although non-steroidal anti-inflammatory drugs(NSAIDs ) , which are non-selective COX inhibitors , have been very often used as painkillers , their side effects such as gastrointestinal hemorrhage remain a serious problem .',
  'This case illustrates that decreased intestinal motility can be a severe problem for patients taking clozapine , which may lead to life-threatening complications .',
  'Nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy is considered a serious and increasing clinical problem without available treatment .',
  'Although simultaneous use of several systemic NSAIDs has no pharmacological justification , this may raise a serious public health problem with the increasing use of over-the-counter non-steroidal anti-inflammatory agents .',
  'The risk of upper gastrointestinal ( GI ) complications associated with the use of NSAIDs is a serious public health concern .',
  'NSAIDs and self-medication : A serious concern .',
  'Nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal damage is a serious problem in patients , but effective therapy is not available at present .',
  'Non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy is a serious public health problem .',
  'The side effects of conventional non-steroidal anti-inflammatory drugs ( NSAIDs ) on the stomach is undoubtedly a serious public health problem contributing significantly to the morbidity and mortality of patients receiving these drugs .',
  'The treatment of a severe relapse of colitis in a patient who has had one episode of steroid related BIH remains a dilemma .'],
 'nsaid': ['Gastrointestinal ( GI ) toxicity is a major drawback of the chronic use of nonsteroidal anti-inflammatory drugs ( NSAIDs ) .',
  'NSAID gastropathy is a serious , iatrogenic problem of common NSAID usage of major public health dimensions .',
  'Although non-steroidal anti-inflammatory drugs(NSAIDs ) , which are non-selective COX inhibitors , have been very often used as painkillers , their side effects such as gastrointestinal hemorrhage remain a serious problem .',
  'This case illustrates that decreased intestinal motility can be a severe problem for patients taking clozapine , which may lead to life-threatening complications .',
  'Nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy is considered a serious and increasing clinical problem without available treatment .',
  'Although simultaneous use of several systemic NSAIDs has no pharmacological justification , this may raise a serious public health problem with the increasing use of over-the-counter non-steroidal anti-inflammatory agents .',
  'The risk of upper gastrointestinal ( GI ) complications associated with the use of NSAIDs is a serious public health concern .',
  'NSAIDs and self-medication : A serious concern .',
  'Nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal damage is a serious problem in patients , but effective therapy is not available at present .',
  'Non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy is a serious public health problem .',
  'The side effects of conventional non-steroidal anti-inflammatory drugs ( NSAIDs ) on the stomach is undoubtedly a serious public health problem contributing significantly to the morbidity and mortality of patients receiving these drugs .',
  'The treatment of a severe relapse of colitis in a patient who has had one episode of steroid related BIH remains a dilemma .'],
 'gastropathy': ['Gastrointestinal ( GI ) toxicity is a major drawback of the chronic use of nonsteroidal anti-inflammatory drugs ( NSAIDs ) .',
  'NSAID gastropathy is a serious , iatrogenic problem of common NSAID usage of major public health dimensions .',
  'Although non-steroidal anti-inflammatory drugs(NSAIDs ) , which are non-selective COX inhibitors , have been very often used as painkillers , their side effects such as gastrointestinal hemorrhage remain a serious problem .',
  'This case illustrates that decreased intestinal motility can be a severe problem for patients taking clozapine , which may lead to life-threatening complications .',
  'Nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy is considered a serious and increasing clinical problem without available treatment .',
  'Although simultaneous use of several systemic NSAIDs has no pharmacological justification , this may raise a serious public health problem with the increasing use of over-the-counter non-steroidal anti-inflammatory agents .',
  'The risk of upper gastrointestinal ( GI ) complications associated with the use of NSAIDs is a serious public health concern .',
  'NSAIDs and self-medication : A serious concern .',
  'Nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal damage is a serious problem in patients , but effective therapy is not available at present .',
  'Non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy is a serious public health problem .',
  'The side effects of conventional non-steroidal anti-inflammatory drugs ( NSAIDs ) on the stomach is undoubtedly a serious public health problem contributing significantly to the morbidity and mortality of patients receiving these drugs .',
  'The treatment of a severe relapse of colitis in a patient who has had one episode of steroid related BIH remains a dilemma .'],
 'salmonella': ['Salmonella antimicrobial resistance ( AMR ) is a serious concern that can reduce successful treatment of infections , increasing recovery time , medical costs , and mortality rates in humans and animals .',
  'The isolation of salmonellae in apparently healthy and clinically sick dogs in this study indicates a carrier status which may constitute a serious problem in disease control in the study area .',
  'Antibiotic resistance in Salmonella enteritidis and S. typhimurium , one of most frequent etiologic pathogens of food-borne bacterial gastroenteritidis in humans , is a serious health problem worldwide .',
  'Non-typhoidal Salmonella ( NTS ) infection is a serious public health problem globally .',
  'Salmonella infection is a serious concern in poultry farming because of its impact on both economic loss and human health .',
  'Non-typhoidal Salmonella ( NTS ) infection is a serious public health problem globally .',
  'Increasing antimicrobial resistance has become a serious concern worldwide and antimicrobial use in animal agriculture is currently under scrutiny .',
  'Salmonella infections are a serious medical and veterinary problem world-wide and cause concern in the food industry .',
  'Salmonella Heidelberg has been isolated and reported from poultry and poultry products in Brazil since 1962 , whereas Salmonella Enteritidis ( SE ) has only emerged as a serious problem in poultry and public health since 1993 .',
  'Antimicrobial-resistant Salmonella species are threatening to become a serious public health problem .',
  'Salmonellosis is a severe economic threat in poultry and a public health concern .',
  'The emergence of ciprofloxacin-resistant Salmonella represents a serious health problem that must be addressed by Libyan health authorities .',
  'Since it is estimated that these reported cases only represent 1 to 10 % of the real incidence of this disease , it must be concluded that human salmonellosis is a serious problem all over the world .',
  'Campylobacter , a major foodborne pathogen found in poultry products , remains a serious problem facing poultry processors .',
  'Salmonellosis in Equidae is a serious global problem .',
  'The proposed research outlines a serious common concern of Salmonella resistance to antimicrobials following prolonged exposure to the disinfectants ( biocides ) .',
  'Although infection of pigs with Salmonella Typhimurium represents a serious problem , most studies on Salmonella infection have been carried out in other species .',
  'Salmonella is a serious problem for both animal production and public health worldwide .',
  'Enteric fever is a serious public health problem in Pakistan , where multidrug-resistant salmonellosis causes enteric fever with increased morbidity and mortality .',
  'Salmonella enterica serotype Choleraesuis , which is associated with severe human infections and multidrug resistance , poses a serious problem in Taiwan .',
  'The association between egg consumption and Salmonella outbreaks is a serious economic and public health problem .',
  'Salmonella carriage in pigs represents a serious health problem that undoubtedly contributes to the spread of human disease .',
  'Salmonella infection is a distressing health problem worldwide .',
  'The present surveillance data showed a high incidence of salmonellosis in Qatar that poses a serious public health problem .',
  'Salmonella enterica subspecies enterica infection remains a serious problem in a wide range of animals and in man .',
  'The emergence of Salmonella strains that are resistant to a variety of antimicrobials is a serious global public health concern .',
  'The wide spread of antimicrobial-resistant Salmonella has been a serious global human and animal health problem .',
  'Infections with Salmonella enterica serovars remain a serious problem worldwide .',
  'Nosocomial salmonellosis is at present a serious problem for many large therapeutic and prophylactic institutions .',
  'Bacterial kidney disease ( BKD ) caused by Renibacterium salmoninarum ( Rs ) is a serious problem among Pacific Northwest salmon hatcheries and has raised concerns that salmon reared in hatcheries may spread BKD to natural populations .',
  'Horizontal infection of table eggs by food borne , human infection causative agents such as Salmonella is a serious concern for consumers and industry .',
  'Increasing antimicrobial resistance in Salmonella Typhi is a serious public health concern , especially in industrializing countries .',
  'The presence of these virulence genes indicates high pathogenicity potential of these isolates which is a serious public health concern because of zoonotic potential of Salmonella .',
  'In the beef industry , product contamination by Salmonella enterica is a serious public health concern , which may result in human infection and cause significant financial loss due to product recalls .',
  'The rise in antimicrobial resistance in a plethora of nosocomial and opportunistic bacterial pathogens often isolated from commercial eggs , poses a serious public health concern .',
  'Salmonella spp . are a leading cause of human infectious disease worldwide and pose a serious health concern .',
  'Salmonella infections continue to be a serious problem in modern medicine .',
  'Salmonella-infections , the epidemiology and the spread of these germs into the environment are a serious hygienic problem even today .',
  'Salmonella infections are a serious public health problem in developing countries and represent a constant concern for the food industry .',
  'Is salmonellosis still a serious problem in veterinary practice ?'],
 'salmonellosis': ['Salmonella antimicrobial resistance ( AMR ) is a serious concern that can reduce successful treatment of infections , increasing recovery time , medical costs , and mortality rates in humans and animals .',
  'The isolation of salmonellae in apparently healthy and clinically sick dogs in this study indicates a carrier status which may constitute a serious problem in disease control in the study area .',
  'Antibiotic resistance in Salmonella enteritidis and S. typhimurium , one of most frequent etiologic pathogens of food-borne bacterial gastroenteritidis in humans , is a serious health problem worldwide .',
  'Non-typhoidal Salmonella ( NTS ) infection is a serious public health problem globally .',
  'Salmonella infection is a serious concern in poultry farming because of its impact on both economic loss and human health .',
  'Non-typhoidal Salmonella ( NTS ) infection is a serious public health problem globally .',
  'Increasing antimicrobial resistance has become a serious concern worldwide and antimicrobial use in animal agriculture is currently under scrutiny .',
  'Salmonella infections are a serious medical and veterinary problem world-wide and cause concern in the food industry .',
  'Salmonella Heidelberg has been isolated and reported from poultry and poultry products in Brazil since 1962 , whereas Salmonella Enteritidis ( SE ) has only emerged as a serious problem in poultry and public health since 1993 .',
  'Antimicrobial-resistant Salmonella species are threatening to become a serious public health problem .',
  'Salmonellosis is a severe economic threat in poultry and a public health concern .',
  'The emergence of ciprofloxacin-resistant Salmonella represents a serious health problem that must be addressed by Libyan health authorities .',
  'Since it is estimated that these reported cases only represent 1 to 10 % of the real incidence of this disease , it must be concluded that human salmonellosis is a serious problem all over the world .',
  'Campylobacter , a major foodborne pathogen found in poultry products , remains a serious problem facing poultry processors .',
  'Salmonellosis in Equidae is a serious global problem .',
  'The proposed research outlines a serious common concern of Salmonella resistance to antimicrobials following prolonged exposure to the disinfectants ( biocides ) .',
  'Although infection of pigs with Salmonella Typhimurium represents a serious problem , most studies on Salmonella infection have been carried out in other species .',
  'Salmonella is a serious problem for both animal production and public health worldwide .',
  'Enteric fever is a serious public health problem in Pakistan , where multidrug-resistant salmonellosis causes enteric fever with increased morbidity and mortality .',
  'Salmonella enterica serotype Choleraesuis , which is associated with severe human infections and multidrug resistance , poses a serious problem in Taiwan .',
  'The association between egg consumption and Salmonella outbreaks is a serious economic and public health problem .',
  'Salmonella carriage in pigs represents a serious health problem that undoubtedly contributes to the spread of human disease .',
  'Salmonella infection is a distressing health problem worldwide .',
  'The present surveillance data showed a high incidence of salmonellosis in Qatar that poses a serious public health problem .',
  'Salmonella enterica subspecies enterica infection remains a serious problem in a wide range of animals and in man .',
  'The emergence of Salmonella strains that are resistant to a variety of antimicrobials is a serious global public health concern .',
  'The wide spread of antimicrobial-resistant Salmonella has been a serious global human and animal health problem .',
  'Infections with Salmonella enterica serovars remain a serious problem worldwide .',
  'Nosocomial salmonellosis is at present a serious problem for many large therapeutic and prophylactic institutions .',
  'Bacterial kidney disease ( BKD ) caused by Renibacterium salmoninarum ( Rs ) is a serious problem among Pacific Northwest salmon hatcheries and has raised concerns that salmon reared in hatcheries may spread BKD to natural populations .',
  'Horizontal infection of table eggs by food borne , human infection causative agents such as Salmonella is a serious concern for consumers and industry .',
  'Increasing antimicrobial resistance in Salmonella Typhi is a serious public health concern , especially in industrializing countries .',
  'The presence of these virulence genes indicates high pathogenicity potential of these isolates which is a serious public health concern because of zoonotic potential of Salmonella .',
  'In the beef industry , product contamination by Salmonella enterica is a serious public health concern , which may result in human infection and cause significant financial loss due to product recalls .',
  'The rise in antimicrobial resistance in a plethora of nosocomial and opportunistic bacterial pathogens often isolated from commercial eggs , poses a serious public health concern .',
  'Salmonella spp . are a leading cause of human infectious disease worldwide and pose a serious health concern .',
  'Salmonella infections continue to be a serious problem in modern medicine .',
  'Salmonella-infections , the epidemiology and the spread of these germs into the environment are a serious hygienic problem even today .',
  'Salmonella infections are a serious public health problem in developing countries and represent a constant concern for the food industry .',
  'Is salmonellosis still a serious problem in veterinary practice ?'],
 'mesenteric': ['Diagnosis and therapy of mesenteric ischaemia as the cause of an acute abdomen is a serious problem because of its 60 - 80 % mortality .',
  '[ Acute mesenteric ischemia : a severe problem in digestive pathology ] .',
  'Intestinal ischemia-reperfusion injury is a serious and widespread clinical problem .',
  'Injury to the intestinal mucosa is a life-threatening problem in a variety of clinical disorders , including hemorrhagic shock , trauma , burn , pancreatitis , and heat stroke .',
  'Intestinal ischemia-reperfusion ( I/R ) injury is a life-threatening vascular emergency and has long been a disturbing problem for surgeons .',
  'Acute mesenteric ischemia is highly lethal and therefore a serious problem for surgery and intensive care medicine ; accordingly its pathophysiology warrants further study .',
  'Intestinal ischaemia with ensuing gangrene has been a serious clinical problem .',
  'Acute mesenteric ischemia is a serious problem with high morbidity and mortality rates .',
  'Ischemia-reperfusion ( IR ) injury of the small intestine is a serious problem in abdominal aortic aneurysm surgery or small intestine transplantation .',
  'Intestinal ischaemia-reperfusion ( II/R ) injury is a serious clinical problem .',
  'Intestinal ischemia , however , caused , is still a serious and growing clinical problem with an unacceptable mortality rate of over 60 % .',
  'Ischemia is a troublesome problem that can cause intestinal emergencies and complicate the treatment .',
  'Intestinal edema remains a serious clinical problem , and novel approaches to study its pathophysiology are needed .',
  'Intestinal ischemia and reperfusion ( IR ) syndrome is a life-threatening dilemma caused by diverse events .',
  'Intestinal ischemia-reperfusion ( I/R ) is a serious clinical dilemma with high morbidity and mortality .',
  'As a complication after surgery for abdominal aortic aneurysms , colonic ischemia remains a serious problem , especially in cases of ruptured AAA .',
  'Chronic mesenteric ischemia is a life-threatening clinical problem resulting in death from inanition and/or bowel infarction , if left untreated , albeit low disease prevalence .',
  'Mesenteric ischemia is a devastating disease process that frequently challenges clinicians .',
  'Although dysplasia was a serious diagnostic concern , we concluded that ischemia due to the intestinal atresia induced this benign pseudodysplastic regenerative mucosa , judging from the pattern of coexisting inflammation and the literature review .'],
 'ischaemia': ['Diagnosis and therapy of mesenteric ischaemia as the cause of an acute abdomen is a serious problem because of its 60 - 80 % mortality .',
  '[ Acute mesenteric ischemia : a severe problem in digestive pathology ] .',
  'Intestinal ischemia-reperfusion injury is a serious and widespread clinical problem .',
  'Injury to the intestinal mucosa is a life-threatening problem in a variety of clinical disorders , including hemorrhagic shock , trauma , burn , pancreatitis , and heat stroke .',
  'Intestinal ischemia-reperfusion ( I/R ) injury is a life-threatening vascular emergency and has long been a disturbing problem for surgeons .',
  'Acute mesenteric ischemia is highly lethal and therefore a serious problem for surgery and intensive care medicine ; accordingly its pathophysiology warrants further study .',
  'Intestinal ischaemia with ensuing gangrene has been a serious clinical problem .',
  'Acute mesenteric ischemia is a serious problem with high morbidity and mortality rates .',
  'Ischemia-reperfusion ( IR ) injury of the small intestine is a serious problem in abdominal aortic aneurysm surgery or small intestine transplantation .',
  'Intestinal ischaemia-reperfusion ( II/R ) injury is a serious clinical problem .',
  'Intestinal ischemia , however , caused , is still a serious and growing clinical problem with an unacceptable mortality rate of over 60 % .',
  'Ischemia is a troublesome problem that can cause intestinal emergencies and complicate the treatment .',
  'Intestinal edema remains a serious clinical problem , and novel approaches to study its pathophysiology are needed .',
  'Intestinal ischemia and reperfusion ( IR ) syndrome is a life-threatening dilemma caused by diverse events .',
  'Intestinal ischemia-reperfusion ( I/R ) is a serious clinical dilemma with high morbidity and mortality .',
  'As a complication after surgery for abdominal aortic aneurysms , colonic ischemia remains a serious problem , especially in cases of ruptured AAA .',
  'Chronic mesenteric ischemia is a life-threatening clinical problem resulting in death from inanition and/or bowel infarction , if left untreated , albeit low disease prevalence .',
  'Mesenteric ischemia is a devastating disease process that frequently challenges clinicians .',
  'Although dysplasia was a serious diagnostic concern , we concluded that ischemia due to the intestinal atresia induced this benign pseudodysplastic regenerative mucosa , judging from the pattern of coexisting inflammation and the literature review .'],
 'intestine': ['Diagnosis and therapy of mesenteric ischaemia as the cause of an acute abdomen is a serious problem because of its 60 - 80 % mortality .',
  '[ Acute mesenteric ischemia : a severe problem in digestive pathology ] .',
  'Intestinal ischemia-reperfusion injury is a serious and widespread clinical problem .',
  'Injury to the intestinal mucosa is a life-threatening problem in a variety of clinical disorders , including hemorrhagic shock , trauma , burn , pancreatitis , and heat stroke .',
  'Intestinal ischemia-reperfusion ( I/R ) injury is a life-threatening vascular emergency and has long been a disturbing problem for surgeons .',
  'Acute mesenteric ischemia is highly lethal and therefore a serious problem for surgery and intensive care medicine ; accordingly its pathophysiology warrants further study .',
  'Intestinal ischaemia with ensuing gangrene has been a serious clinical problem .',
  'Acute mesenteric ischemia is a serious problem with high morbidity and mortality rates .',
  'Ischemia-reperfusion ( IR ) injury of the small intestine is a serious problem in abdominal aortic aneurysm surgery or small intestine transplantation .',
  'Intestinal ischaemia-reperfusion ( II/R ) injury is a serious clinical problem .',
  'Intestinal ischemia , however , caused , is still a serious and growing clinical problem with an unacceptable mortality rate of over 60 % .',
  'Ischemia is a troublesome problem that can cause intestinal emergencies and complicate the treatment .',
  'Intestinal edema remains a serious clinical problem , and novel approaches to study its pathophysiology are needed .',
  'Intestinal ischemia and reperfusion ( IR ) syndrome is a life-threatening dilemma caused by diverse events .',
  'Intestinal ischemia-reperfusion ( I/R ) is a serious clinical dilemma with high morbidity and mortality .',
  'As a complication after surgery for abdominal aortic aneurysms , colonic ischemia remains a serious problem , especially in cases of ruptured AAA .',
  'Chronic mesenteric ischemia is a life-threatening clinical problem resulting in death from inanition and/or bowel infarction , if left untreated , albeit low disease prevalence .',
  'Mesenteric ischemia is a devastating disease process that frequently challenges clinicians .',
  'Although dysplasia was a serious diagnostic concern , we concluded that ischemia due to the intestinal atresia induced this benign pseudodysplastic regenerative mucosa , judging from the pattern of coexisting inflammation and the literature review .'],
 'rabies': ['Canine rabies remains a serious public health problem in Thailand .',
  'Rabies is a serious problem in the 11 states that make up CentralAsia .',
  'Rabies infection of domestic and wild animals is a serious problem throughout the world .',
  'The cases of rabies increase greatly in recent years in China and rabies continues to be a serious problem in developing countries due to the reservoirs of Rabies virus in dogs and wildlife vectors .',
  "Excessive barking can be a mild annoyance or a severe problem , particularly if the owner is under pressure from other people to stop the dog 's behavior .",
  'Bovine rabies continues to be a serious problem facing the cattle industry in South and Central America .',
  'Canine rabies , responsible for most human rabies deaths , is a serious global public health concern .',
  'Rabies is a fatal neurological pathogen that is a persistent problem throughout the developing world where it is spread primarily by domestic dogs .',
  'Rabies : a rare disease but a serious pediatric problem .',
  'Rabies remains a serious public health problem in many developing countries .',
  'Rabies is a fatal viral zoonosis and a serious public health problem .',
  'Rabies is endemic in the Central African Republic ( CAR ) and a neglected enzootic disease which represents a serious public health problem .',
  'Rabies is an endemic disease in Brazil , where it is considered a serious public health problem .',
  'Rabies is a fatal neurological disease and a persistent global problem .',
  'In this ecosystem , paralytic rabies is a serious economic problem because of its frequency and readiness to spread ( 41 separate outbreaks were recorded in addition to an epidemic ) .',
  'Dog bite injuries to the face are a serious , yet modifiable public health concern .',
  'Rabies is a preventable neglected public health problem and associated with multiple cultural , religious , and social practices , myths in our country .',
  'In Tunisia , rabies continues to be considered as a serious public health concern .',
  'Rabies has emerged as a serious problem in the most recent years in northern China .',
  'In India , rabies is enzootic and is a serious public health and economic problem .',
  'Rabies is a fatal disease caused by infection with rabies virus ( RABV ) , and human rabies is still a critical public-health concern in China .',
  'Rabies is a fatal viral zoonosis and a serious public health problem .',
  'Canine rabies remains a serious public health problem in Thailand .',
  'Rabies is a fatal viral zoonosis and a serious public health problem .',
  'Because of its association with dogs , rabies virus ( RABV ) is still endemic in Thailand , where it is a serious public health problem .',
  'Human animal-bite injuries are a serious public health problem due to associated risk for rabies virus exposure .',
  'Rabies , an acute progressive encephalomyelitis , continues to be a serious public health problem in India and many other countries in Asia and Africa .',
  'Rabies remains a serious problem in China with three epidemics since 1949 and the country in the midst of the third epidemic .',
  'A severe dog bite in a small child . ( How can it become an ethical dilemma ? ) .',
  'Rabies is a fatal zoonotic disease caused by rabies virus ( RABV ) and remains a public health problem in Malaysia .',
  'Human rabies , often contracted through dog bites , is a serious but neglected public health problem in the tropics , including Ghana .',
  'Rabies , a fatal encephalitis of viral origin , is still a major health problem in the developing world .',
  'Rabies is a severe problem in the Phillippines .',
  'Rabies among dogs remains a considerable risk to humans and constitutes a serious public health concern in many parts of the world .',
  'Facial injuries caused by dog bites pose a serious problem .',
  'Rabies is a fatal viral zoonosis and a serious public health problem .',
  'As Her Royal Highness Princess Haya of Jordan pointed out in a video to mark World Rabies Day on 28 September 2013 , rabies is a serious world public health problem that is all too often underestimated and even neglected .',
  'Rabies is a serious concern world-wide .',
  'Rabies is invariably a fatal encephalomyelitis that is considered to be a serious public health problem .',
  'In conclusion , the prevalence of rabies cases in children in China remains a serious concern , the number and immune status of dogs in rural areas , and knowledge of rabies by risk populations should be considered in future rabies prevention and control programs .',
  'Rabies is a fatal viral zoonosis and a serious public health problem .',
  'Rabies is a neglected enzootic disease which represents a serious public health problem .',
  'In China canine rabies poses a serious public health problem in that human mortality ranks the second highest globally .',
  'Rabies is a serious concern to public health and wildlife management worldwide .',
  'Rabies poses a serious public health concern in developing countries such as India .',
  'Rabies is a fatal and viral zoonosis that causes acute , progressive encephalitis and remains an important concern in public health .',
  'Raccoon rabies remains a serious public health problem throughout much of the eastern seaboard of North America due to the urban nature of the reservoir host and the many challenges inherent in multi-jurisdictional efforts to administer co-ordinated and comprehensive wildlife rabies control programmes .',
  'In México , rabies continues to be a serious health and economic problem , and urban rabies still predominates with a large number of human and animal cases recorded yearly .',
  'Rabies is invariably a fatal encephalomyelitis that is considered to be a serious public health problem .',
  'Rabies is a widespread disease in African domestic dogs and a serious public health problem in developing countries .',
  'Rabies is a fatal disease once contracted , and a serious public health problem .',
  'Rabies is a fatal viral zoonosis and a serious public health problem .',
  'Dog bites constitute a serious , yet preventable , public health concern that requires targeted , community-specific efforts .',
  'Dog bites are a serious public health concern .',
  'Rabies is a serious public health problem in Asia .',
  'Rabies remains a serious public health problem in many developing countries .',
  'Rabies , a fatal but preventable zoonosis , is a major public health problem in developing countries .',
  'Aggressive behavior in pet dogs is a serious problem for dog owners across the globe , with bite injuries representing a serious risk to both people and other dogs .',
  'Rabies is a fatal acute viral disease of the central nervous system , which is a serious public health problem in Asian and African countries .',
  'Rabies is a fatal anthropozoonotic viral infection of the central nervous system that remains a serious public health problem in many countries .',
  'Canine rabies is a serious health problem in Morocco and about 22 human deaths are reported yearly . Following the World Health Organization ( WHO ) recommendations , Moroccan authorities evaluated oral rabies vaccine baits specially designed for dogs .',
  'Usually , monkey bites and injuries do not present a serious problem in daily routine because they occur sporadically .',
  'Rabies , a zoonotic viral encephalitis , continues to be a serious public health problem in India and several other countries in Asia and Africa .',
  'Rabies continues to be a serious problem in both developed and developing nations due to the reservoir of rabies virus in wildlife vectors .',
  'Dog bite injuries in children are a preventable health problem .'],
 'lactamases': ['Resistance due to New Delhi metallo-β-lactamase ( NDM ) and OXA-48/181 continues to emerge as a threat which is associated with nosocomial outbreaks and is a serious healthcare concern .',
  '[ Wide-spectrum beta-lactamases : are they a serious problem today in Spain ? ] .',
  'Also , the emergence of metallo-beta-lactamases (MBL)-producing bacteria is becoming a severe therapeutic problem .',
  'The spread of carbapenem-resistant Enterobacteriaceae ( CRE ) mediated by New Delhi metallo-β-lactamase ( NDM ) poses a serious challenge to clinicians and has become a major public health concern .',
  'β-lactamases viz . , extended spectrum β-lactamase ( ESBL ) , AmpC , and metallo β-lactamase ( MBL ) production in Klebsiella pneumoniae has led to a serious concern about septicemic neonates in Neonatal Intensive Care Units due to high resistance against commonly used antimicrobials .',
  'Production of AmpC and extended spectrum beta-lactamases among urinary isolates has created a serious problem to the successful management of the urinary tract infection .',
  'Extended-spectrum β-lactamases (ESBLs)-producing Salmonella is considered a serious concern to public health worldwide .',
  'Carbapenemases , which are β-lactamases with the capacity to hydrolyze or inactivate carbapenems , have become a serious concern as they have the largest hydrolytic spectrum and therefore limit the utility of most β-lactam antibiotics .',
  'In contrast , extended spectrum beta lactamases ( ESBL ) and colistin resistance are becoming a serious problem in animals .',
  'Extended-spectrum β-lactamase-producing Escherichia coli ( ESBL-EC ) are a serious public health concern worldwide .',
  'Extended-spectrum β-lactamases ( ESβLs ) pose a serious problem in the treatment of urinary tract infections ( UTIs ) .',
  'Resistance to a wide variety of common antimicrobials has made the proliferation of Extended spectrum β-lactmase ( ESBL ) producing strains a serious global health concern that has complicated treatment strategies .',
  'The variety of extended-spectrum beta-lactamases found among members of the family Enterobacteriaceae isolated from major medical centers in South Africa is troubling and adds to the growing list of countries where these enzymes pose a serious problem for antimicrobial therapy .',
  'Surgical wound infection is a serious problem , especially with metallo-beta lactamases (MBLs)- producing gram-negative bacteria as Pseudomonas aeruginosa .',
  'Emerging β-lactamase-producing-bacteria ( ESBL , AmpC and carbapenemases ) have become a serious problem in our community due to their startling spread worldwide and their ability to cause infections which are difficult to treat .',
  'Infections caused by metallo-beta-lactamase producing gram-negative bacteria are becoming a serious problem in Japanese clinical settings despite the recent progress in medical technology .',
  'Infections caused by extended-spectrum β-lactamase (ESBL)-producing bacteria have become a serious clinical concern worldwide .',
  'The spread of Extended-Spectrum beta (β)-Lactamases (ESBL)-producing Enterobacteriaceae has become a serious global problem .',
  'Extended-spectrum beta-lactamases and AmpC beta-lactamase producers among Enterobacteriaceae isolates from this ICU continued to be a serious therapeutic problem , although the carbapenems were highly active against these resistance phenotypes .',
  'The increasing frequency of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae is becoming a serious public health concern .',
  'Antimicrobial resistance ( AMR ) due to the emergence and spread of extended-spectrum beta-lactamase ( ESBL ) producing bacteria are becoming a serious global public health concern .',
  'The spread of multidrug-resistant Enterobacteriaceae related to the production of extended-spectrum β-lactamases and carbapenemases is a serious public health problem worldwide .',
  'The spread of multidrug-resistant Enterobacteriaceae related to the production of extended-spectrum β-lactamases ( ESBL ) and carbapenemases is a serious public health problem worldwide .',
  'The continuing evolution of beta-lactamases that are capable of hydrolyzing our most potent beta-lactams presents a vexing clinical problem , in particular since a number of them are resistant to inhibitors .',
  'The emergence of metallo-β-lactamase (MBL)-producing Enterobacteriaceae is a serious public health concern .',
  'The global dissemination of metallo-ß-lactamase (MBL)-producing carbapenem resistant Enterobacterales ( CRE ) is a serious public health concern .',
  'Infections with bacteria that contain hydrolytic beta-lactamase enzymes are becoming a serious problem in the United States .',
  'Multiresistant Enterobacteriaceae producing extended-spectrum β-lactamases ( ESBL ) constitute a serious healthcare concern .',
  'Metallo-β-lactamase ( MBL ) producing bacteria constitute nowadays a serious global concern worldwide .',
  'Metallo-beta-lactamase ( MBL ) producing Pseudomonas aeruginosa in the burn patients is a leading cause of morbidity and mortality and remains a serious health concern among the clinicians .',
  'Serine and metallo-carbapenemases are a serious health concern due to their capability to hydrolyze nearly all β-lactam antibiotics .',
  'In recent years , the increasing instance of carbapenem-resistant A. baumannii producing metallo-beta-lactamases ( MBLs ) or OXAtype beta-lactamases is causing a serious clinical problem .',
  'Bloodstream infection caused by extended-spectrum beta-lactamase (ESBL)-producing pathogens has become a serious concern worldwide .',
  'The more frequent occurrence of infections caused by Bush group 1 beta-lactamase producing organisms , including species of the genus Enterobacter , is a serious problem in this field .',
  'The UTIs which are caused by multidrug resistant Extended-Spectrum Beta-Lactamase ( ESBL ) producing bacteria further pose a severe problem , as the treatment options are limited .',
  'The worldwide proliferation of life-threatening metallo-β-lactamase (MBL)-producing Gram-negative bacteria is a serious concern to public health .',
  'The existence of multidrug-resistant organisms , including extended-spectrum beta-lactamases ( ESBLs ) , is on rise across the globe and is becoming a severe problem .',
  'Infections caused by Enterobacteriaceae producing extended-spectrum β-lactamases ( ESBLs ) are a serious therapeutic and clinical problem .'],
 'lactamase': ['Resistance due to New Delhi metallo-β-lactamase ( NDM ) and OXA-48/181 continues to emerge as a threat which is associated with nosocomial outbreaks and is a serious healthcare concern .',
  '[ Wide-spectrum beta-lactamases : are they a serious problem today in Spain ? ] .',
  'Also , the emergence of metallo-beta-lactamases (MBL)-producing bacteria is becoming a severe therapeutic problem .',
  'The spread of carbapenem-resistant Enterobacteriaceae ( CRE ) mediated by New Delhi metallo-β-lactamase ( NDM ) poses a serious challenge to clinicians and has become a major public health concern .',
  'β-lactamases viz . , extended spectrum β-lactamase ( ESBL ) , AmpC , and metallo β-lactamase ( MBL ) production in Klebsiella pneumoniae has led to a serious concern about septicemic neonates in Neonatal Intensive Care Units due to high resistance against commonly used antimicrobials .',
  'Production of AmpC and extended spectrum beta-lactamases among urinary isolates has created a serious problem to the successful management of the urinary tract infection .',
  'Extended-spectrum β-lactamases (ESBLs)-producing Salmonella is considered a serious concern to public health worldwide .',
  'Carbapenemases , which are β-lactamases with the capacity to hydrolyze or inactivate carbapenems , have become a serious concern as they have the largest hydrolytic spectrum and therefore limit the utility of most β-lactam antibiotics .',
  'In contrast , extended spectrum beta lactamases ( ESBL ) and colistin resistance are becoming a serious problem in animals .',
  'Extended-spectrum β-lactamase-producing Escherichia coli ( ESBL-EC ) are a serious public health concern worldwide .',
  'Extended-spectrum β-lactamases ( ESβLs ) pose a serious problem in the treatment of urinary tract infections ( UTIs ) .',
  'Resistance to a wide variety of common antimicrobials has made the proliferation of Extended spectrum β-lactmase ( ESBL ) producing strains a serious global health concern that has complicated treatment strategies .',
  'The variety of extended-spectrum beta-lactamases found among members of the family Enterobacteriaceae isolated from major medical centers in South Africa is troubling and adds to the growing list of countries where these enzymes pose a serious problem for antimicrobial therapy .',
  'Surgical wound infection is a serious problem , especially with metallo-beta lactamases (MBLs)- producing gram-negative bacteria as Pseudomonas aeruginosa .',
  'Emerging β-lactamase-producing-bacteria ( ESBL , AmpC and carbapenemases ) have become a serious problem in our community due to their startling spread worldwide and their ability to cause infections which are difficult to treat .',
  'Infections caused by metallo-beta-lactamase producing gram-negative bacteria are becoming a serious problem in Japanese clinical settings despite the recent progress in medical technology .',
  'Infections caused by extended-spectrum β-lactamase (ESBL)-producing bacteria have become a serious clinical concern worldwide .',
  'The spread of Extended-Spectrum beta (β)-Lactamases (ESBL)-producing Enterobacteriaceae has become a serious global problem .',
  'Extended-spectrum beta-lactamases and AmpC beta-lactamase producers among Enterobacteriaceae isolates from this ICU continued to be a serious therapeutic problem , although the carbapenems were highly active against these resistance phenotypes .',
  'The increasing frequency of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae is becoming a serious public health concern .',
  'Antimicrobial resistance ( AMR ) due to the emergence and spread of extended-spectrum beta-lactamase ( ESBL ) producing bacteria are becoming a serious global public health concern .',
  'The spread of multidrug-resistant Enterobacteriaceae related to the production of extended-spectrum β-lactamases and carbapenemases is a serious public health problem worldwide .',
  'The spread of multidrug-resistant Enterobacteriaceae related to the production of extended-spectrum β-lactamases ( ESBL ) and carbapenemases is a serious public health problem worldwide .',
  'The continuing evolution of beta-lactamases that are capable of hydrolyzing our most potent beta-lactams presents a vexing clinical problem , in particular since a number of them are resistant to inhibitors .',
  'The emergence of metallo-β-lactamase (MBL)-producing Enterobacteriaceae is a serious public health concern .',
  'The global dissemination of metallo-ß-lactamase (MBL)-producing carbapenem resistant Enterobacterales ( CRE ) is a serious public health concern .',
  'Infections with bacteria that contain hydrolytic beta-lactamase enzymes are becoming a serious problem in the United States .',
  'Multiresistant Enterobacteriaceae producing extended-spectrum β-lactamases ( ESBL ) constitute a serious healthcare concern .',
  'Metallo-β-lactamase ( MBL ) producing bacteria constitute nowadays a serious global concern worldwide .',
  'Metallo-beta-lactamase ( MBL ) producing Pseudomonas aeruginosa in the burn patients is a leading cause of morbidity and mortality and remains a serious health concern among the clinicians .',
  'Serine and metallo-carbapenemases are a serious health concern due to their capability to hydrolyze nearly all β-lactam antibiotics .',
  'In recent years , the increasing instance of carbapenem-resistant A. baumannii producing metallo-beta-lactamases ( MBLs ) or OXAtype beta-lactamases is causing a serious clinical problem .',
  'Bloodstream infection caused by extended-spectrum beta-lactamase (ESBL)-producing pathogens has become a serious concern worldwide .',
  'The more frequent occurrence of infections caused by Bush group 1 beta-lactamase producing organisms , including species of the genus Enterobacter , is a serious problem in this field .',
  'The UTIs which are caused by multidrug resistant Extended-Spectrum Beta-Lactamase ( ESBL ) producing bacteria further pose a severe problem , as the treatment options are limited .',
  'The worldwide proliferation of life-threatening metallo-β-lactamase (MBL)-producing Gram-negative bacteria is a serious concern to public health .',
  'The existence of multidrug-resistant organisms , including extended-spectrum beta-lactamases ( ESBLs ) , is on rise across the globe and is becoming a severe problem .',
  'Infections caused by Enterobacteriaceae producing extended-spectrum β-lactamases ( ESBLs ) are a serious therapeutic and clinical problem .'],
 'enterobacteriaceae': ['Resistance due to New Delhi metallo-β-lactamase ( NDM ) and OXA-48/181 continues to emerge as a threat which is associated with nosocomial outbreaks and is a serious healthcare concern .',
  'The emergence and rapid spread of carbapenemase-producing Enterobacterales represents a serious public health concern .',
  '[ Wide-spectrum beta-lactamases : are they a serious problem today in Spain ? ] .',
  'Also , the emergence of metallo-beta-lactamases (MBL)-producing bacteria is becoming a severe therapeutic problem .',
  'The spread of carbapenem-resistant Enterobacteriaceae ( CRE ) mediated by New Delhi metallo-β-lactamase ( NDM ) poses a serious challenge to clinicians and has become a major public health concern .',
  'β-lactamases viz . , extended spectrum β-lactamase ( ESBL ) , AmpC , and metallo β-lactamase ( MBL ) production in Klebsiella pneumoniae has led to a serious concern about septicemic neonates in Neonatal Intensive Care Units due to high resistance against commonly used antimicrobials .',
  'Production of AmpC and extended spectrum beta-lactamases among urinary isolates has created a serious problem to the successful management of the urinary tract infection .',
  'The emergence of carbapenem resistant Escherichia coli represents a serious public health concern .',
  'Extended-spectrum β-lactamases (ESBLs)-producing Salmonella is considered a serious concern to public health worldwide .',
  'Carbapenemases , which are β-lactamases with the capacity to hydrolyze or inactivate carbapenems , have become a serious concern as they have the largest hydrolytic spectrum and therefore limit the utility of most β-lactam antibiotics .',
  'Carbapenem-resistant organism ( CRO ) colonization is a serious problem that increases the risk of infection and contributes to dissemination of antimicrobial resistance in healthcare-associated environments .',
  'Carbapenem resistant Enterobacteriaceae ( CRE ) has become a serious public health problem .',
  'The emergence and spread of carbapenemase-producing Gram-negative bacteria represents a serious public health concern .',
  'This Gram-negative bacterium species has become a serious concern due to its dramatic increase in the levels of multiple antibiotic resistances , particularly to carbapenems .',
  'In contrast , extended spectrum beta lactamases ( ESBL ) and colistin resistance are becoming a serious problem in animals .',
  'Infections caused by carbapenem-resistant enterobacteria ( CRE ) are classified as a serious problem .',
  'Carbapenem-resistant Gram-negative pathogens have progressively disseminated to different countries worldwide , presenting a serious public health concern .',
  'Extended-spectrum β-lactamase-producing Escherichia coli ( ESBL-EC ) are a serious public health concern worldwide .',
  'Extended-spectrum β-lactamases ( ESβLs ) pose a serious problem in the treatment of urinary tract infections ( UTIs ) .',
  'The emergence and spread of Carbapenem-resistant Escherichia coli ( CREC ) is becoming a serious problem in Chinese hospitals , however , the data on this is scarce .',
  'The spread of plasmids carrying carbapenemase genes resulting in fulminant antimicrobial resistance is a severe concern .',
  'The increasing spread of carbapenem resistance is a serious global public health concern that negatively affects human and animal health .',
  'Resistance to a wide variety of common antimicrobials has made the proliferation of Extended spectrum β-lactmase ( ESBL ) producing strains a serious global health concern that has complicated treatment strategies .',
  'The variety of extended-spectrum beta-lactamases found among members of the family Enterobacteriaceae isolated from major medical centers in South Africa is troubling and adds to the growing list of countries where these enzymes pose a serious problem for antimicrobial therapy .',
  'Surgical wound infection is a serious problem , especially with metallo-beta lactamases (MBLs)- producing gram-negative bacteria as Pseudomonas aeruginosa .',
  'Emerging β-lactamase-producing-bacteria ( ESBL , AmpC and carbapenemases ) have become a serious problem in our community due to their startling spread worldwide and their ability to cause infections which are difficult to treat .',
  'Carbapenem-resistant Enterobacteriaceae infections are a serious health care problem , because of the high mortality .',
  'Infections caused by metallo-beta-lactamase producing gram-negative bacteria are becoming a serious problem in Japanese clinical settings despite the recent progress in medical technology .',
  'Multidrug resistant bacteria are a serious worldwide problem , especially carbapenem-resistant',
  'Infections caused by extended-spectrum β-lactamase (ESBL)-producing bacteria have become a serious clinical concern worldwide .',
  'Rapid dissemination of carbapenemase-producing Enterobacteriaceae is a serious concern in patient care and is a problem that has emerged in western Europe .',
  'The spread of Extended-Spectrum beta (β)-Lactamases (ESBL)-producing Enterobacteriaceae has become a serious global problem .',
  'Extended-spectrum beta-lactamases and AmpC beta-lactamase producers among Enterobacteriaceae isolates from this ICU continued to be a serious therapeutic problem , although the carbapenems were highly active against these resistance phenotypes .',
  'The increasing frequency of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae is becoming a serious public health concern .',
  'Antimicrobial resistance ( AMR ) due to the emergence and spread of extended-spectrum beta-lactamase ( ESBL ) producing bacteria are becoming a serious global public health concern .',
  'The development of colistin resistance in carbapenem-resistant strains poses a serious public health problem .',
  'Infections with Carbapenem-Resistant Gram-Negative Bacteria are a Serious Problem Among Critically Ill Children : A Single-Centre Retrospective Study .',
  'The spread of multidrug-resistant Enterobacteriaceae related to the production of extended-spectrum β-lactamases and carbapenemases is a serious public health problem worldwide .',
  'The spread of multidrug-resistant Enterobacteriaceae related to the production of extended-spectrum β-lactamases ( ESBL ) and carbapenemases is a serious public health problem worldwide .',
  'The continuing evolution of beta-lactamases that are capable of hydrolyzing our most potent beta-lactams presents a vexing clinical problem , in particular since a number of them are resistant to inhibitors .',
  'The emergence of metallo-β-lactamase (MBL)-producing Enterobacteriaceae is a serious public health concern .',
  'The global dissemination of metallo-ß-lactamase (MBL)-producing carbapenem resistant Enterobacterales ( CRE ) is a serious public health concern .',
  'Infections with bacteria that contain hydrolytic beta-lactamase enzymes are becoming a serious problem in the United States .',
  'Multiresistant Enterobacteriaceae producing extended-spectrum β-lactamases ( ESBL ) constitute a serious healthcare concern .',
  'The transmission of hospital-acquired Carbapenem-resistant Enterobacteriaceae ( CRE ) is a serious and growing concern in hospitals worldwide .',
  'Metallo-β-lactamase ( MBL ) producing bacteria constitute nowadays a serious global concern worldwide .',
  'Metallo-beta-lactamase ( MBL ) producing Pseudomonas aeruginosa in the burn patients is a leading cause of morbidity and mortality and remains a serious health concern among the clinicians .',
  'Serine and metallo-carbapenemases are a serious health concern due to their capability to hydrolyze nearly all β-lactam antibiotics .',
  'In recent years , the increasing instance of carbapenem-resistant A. baumannii producing metallo-beta-lactamases ( MBLs ) or OXAtype beta-lactamases is causing a serious clinical problem .',
  'Bloodstream infection caused by extended-spectrum beta-lactamase (ESBL)-producing pathogens has become a serious concern worldwide .',
  'The more frequent occurrence of infections caused by Bush group 1 beta-lactamase producing organisms , including species of the genus Enterobacter , is a serious problem in this field .',
  'The UTIs which are caused by multidrug resistant Extended-Spectrum Beta-Lactamase ( ESBL ) producing bacteria further pose a severe problem , as the treatment options are limited .',
  'The dissemination of carbapenemase-producing Enterobacteriaceae is currently considered a serious clinical problem due to the failure in the treatment of infections produced by them .',
  'Carbapenemase-producing Enterobacteriaceae ( CPE ) are a serious public health concern and represent a major threat to immunocompromised hosts , including solid organ ( SOT ) and stem cell transplant ( HSCT ) recipients .',
  'The worldwide proliferation of life-threatening metallo-β-lactamase (MBL)-producing Gram-negative bacteria is a serious concern to public health .',
  'The existence of multidrug-resistant organisms , including extended-spectrum beta-lactamases ( ESBLs ) , is on rise across the globe and is becoming a severe problem .',
  'Infections caused by Enterobacteriaceae producing extended-spectrum β-lactamases ( ESBLs ) are a serious therapeutic and clinical problem .'],
 'ipv': ['Intimate partner violence ( IPV ) is a serious social problem that is often hidden , unnoticed or ignored .',
  'Intimate partner violence ( IPV ) is a serious public health problem in the United States with adverse consequences for affected individuals and families .',
  'Intimate partner violence ( IPV ) is a serious public health problem .',
  'The Centers for Disease Control and Prevention describes intimate partner violence ( IPV ) as a serious , preventable problem .',
  'Intimate partner violence ( IPV ) is a serious , and preventable , public health problem in the United States .',
  'Intimate partner violence ( IPV ) is a serious public health concern for all ; however , women who experience IPV are more likely to sustain injury and report adverse health consequences .',
  'Intimate partner violence ( IPV ) against women is a serious public health and social problem and is associated with a host of adverse health outcomes and behaviors , HIV risk behaviors included , among women who are victimized .',
  'Intimate partner violence ( IPV ) is a serious public health concern and impacts the entire family unit , particularly children .',
  'Intimate partner violence ( IPV ) is a serious public health problem that disproportionately affects adolescent women seeking family planning services .',
  'Intimate partner violence ( IPV ) is a serious , under-reported public health problem in the United States .',
  "Intimate Partner Violence ( IPV ) is a serious violation of women 's human rights and a dominant chronic global public health problem .",
  'Intimate partner violence ( IPV ) against women is a serious problem throughout the world .',
  'Intimate partner violence ( IPV ) is a serious public health problem that frequently results in oral-maxillofacial traumas , generating high social and economic costs .',
  'Intimate partner violence ( IPV ) , commonly accompanied by controlling behavior , is a serious public health concern in sub-Saharan Africa .',
  'Intimate partner violence ( IPV ) is a serious public health concern that affects many Latinx couples .',
  'Intimate Partner Violence ( IPV ) is a serious international problem .',
  "Intimate partner violence ( IPV ) is a serious , widespread problem that negatively affects women 's lives , including their economic status .",
  'Intimate partner violence ( IPV ) is a serious public health problem , affecting every 1 in 4 women in their lifetime .',
  'Intimate partner violence ( IPV ) is a serious mental and physical health concern worldwide .',
  'In the United States ( U.S. ) , intimate partner violence ( IPV ) is a serious public health concern , mainly affecting the health and well-being of women .',
  'Intimate partner violence ( IPV ) has emerged as a serious problem among women in drug treatment programs .',
  'Intimate partner violence ( IPV ) is a serious public health problem leading many health care organizations to recommend universal screening as part of standard health care practice .',
  'Intimate partner violence ( IPV ) is a serious health concern , but little is known about prevalence of IPV in the armed forces , as military members cope with the pressures of long-standing operations .',
  'Intimate partner violence against women ( IPVAW ) is a serious and widespread problem worldwide .',
  'In Sri Lanka , over one in three women experience intimate partner violence ( IPV ) victimization in their lifetime , making it a serious public health concern .',
  'Domestic intimate partner violence ( IPV ) is a serious health care concern , which may be mitigated by early detection , screening , and intervention .',
  'Intimate partner violence ( IPV ) is a serious and widespread problem .',
  'Intimate partner violence ( IPV ) is a serious public health problem with known negative physical and mental health outcomes for women exposed .',
  'Intimate Partner Violence ( IPV ) is a serious , preventable public health problem that affects millions of people worldwide .',
  'Intimate partner violence ( IPV ) directed towards women is a serious public health problem .',
  'Intimate partner violence ( IPV ) is a serious public health problem , linked with a number of poor health outcomes .',
  'Intimate partner violence ( IPV ) is a serious and preventable public health problem .',
  "Intimate partner violence ( IPV ) violates women 's human rights and is a serious public health concern .",
  'Intimate partner violence ( IPV ) is a serious , devastating , and prevalent problem .',
  'Intimate partner violence ( IPV ) is prevalent throughout the world and is a devastating public health problem .',
  'Intimate partner violence ( IPV ) is a serious , pervasive problem ; however , professional literature focused on psychotherapy for women experiencing IPV is limited .',
  'Intimate partner violence ( IPV ) among immigrant women is a serious public health problem .',
  'Intimate partner violence is a serious international problem .',
  'Intimate partner violence ( IPV ) is a serious public health problem in the United States and a common cause of injury .',
  'Intimate partner violence ( IPV ) is a severe health problem associated with significant distress and impairment in women .',
  'Intimate partner homicide ( IPH ) is a serious problem throughout the world .',
  'Intimate partner violence ( IPV ) is a serious public health problem associated with increased risk of developing mental health conditions .',
  'Intimate partner violence ( IPV ) is a serious global health problem affecting millions of women worldwide .',
  'Intimate partner violence ( IPV ) is a serious problem with devastating health consequences .',
  'Intimate partner violence ( IPV ) is a serious concern for women that is associated with significant adverse health effects .',
  'Intimate partner violence ( IPV ) victimization is a serious public health problem in the world .',
  'IPV is thought to be a serious problem in Guyana , and this study confirms a high prevalence ( 16 % ) of IPV in women presenting with traumatic injuries to the Georgetown Public Hospital Corporation ED . This is likely a significant underestimate of the true prevalence .',
  'Intimate partner violence ( IPV ) is a serious social problem in South Korea , but the IPV reporting rate to the police is not high enough .',
  'Intimate partner violence against women ( IPV ) has been identified as a serious public health problem .',
  'Intimate partner violence ( IPV ) is a serious and prevalent problem throughout the United States .',
  'Intimate partner violence ( IPV ) is a serious health problem and a leading cause of nonfatal injury in North American females .',
  'Intimate partner violence ( IPV ) is a serious public health problem that disproportionately affects racial/ethnic minorities in the U.S. This study examines risk factors for IPV perpetration that are salient for racial/ethnic minorities ; specifically , we test if racial/ethnic discrimination among Latino men is associated with IPV perpetration , if poor mental health ( MH ) mediates this link , and whether relationships differ by immigrant status .',
  'Female same-sex intimate partner violence ( FSSIPV ) is a serious problem that affects the health and safety of lesbian and bisexual women .',
  'Intimate partner violence ( IPV ) is a serious health concern for women in the United States , and HIV-positive women experience more frequent and severe abuse compared with HIV-negative women .',
  'Intimate partner violence ( IPV ) is a serious public health problem that has received increased attention in the military .'],
 'aquaculture': ['Columnaris disease has long been recognized as a serious problem worldwide which affects both wild and cultured freshwater fish including the commercially important channel catfish ( Ictalurus punctatus ) .',
  'Ascidian soft tunic syndrome ( AsSTS ) caused by Azumiobodo hoyamushi ( A. hoyamushi ) is a serious aquaculture problem that results in mass mortality of ascidians .',
  'An infection of pearl oysters , Pinctada maxima , attributed to a Haplosporidium sp. by Hine and Thorne ( 1998 ) has been detected on 3 occasions and is considered to represent a serious concern to the pearling industry in Australia .',
  'Bacterial infection in the marine environment is a serious problem to maintain the stability of marine ecosystems .',
  'Gray mullet ( Mugilidae ) occur in all seas and are farmed widely around the world , and thus , the risk of their parasites spreading through transport of aquaculture seed is a serious concern .',
  'Melanin accumulations in ectopic locations , in particular muscle , represent a serious quality problem in salmon production .',
  'Grass carp ( Ctenopharyngodon idella ) hemorrhagic disease , caused by grass carp reovirus ( GCRV ) , is emerging as a serious problem in grass carp aquaculture .',
  'During the past decades , Vibrio spp . infections have been a serious problem that causes fish blight and very large economic losses , especially in China , Japan , Europe , and North America .',
  "The infectious kinetoplastid Azumiobodo hoyamushi causes ' soft tunic syndrome ' , a serious problem in aquaculture of the edible ascidian Halocynthia roretzi .",
  'Disease-induced mortality of juvenile salmon has become a serious concern in recent years .',
  'It is suggested that THV infection is not a serious problem for the Chinese soft-shelled turtle culture in this region .',
  'Grass carp ( Ctenopharyngodon idella ) hemorrhagic disease , caused by grass carp reovirus ( GCRV ) , is emerging as a serious problem in grass carp aquaculture .',
  'White tail disease ( WTD ) is a serious problem in hatcheries and nursery ponds of Macrobrachium rosenbergii in India .',
  'The marine white spot disease caused by protozoan ectoparasite Cryptocaryon irritans is a severe problem to the large yellow croaker farming industry .',
  'White tail disease ( WTD ) was found to be a serious problem in hatcheries and nursery ponds of Macrobrachium rosenbergii in India .',
  'White tail disease ( WTD ) caused by Macrobrachium rosenbergii nodavirus ( MrNV ) and extra small virus ( XSV ) is a serious problem in prawn hatcheries .',
  'These are lactococcosis caused by Lactococcus garvieae , which is of economical importance in rainbow trout ( Oncorhynchus mykiss ) ; pseudomonadiasis caused by Pseudomonas anguilliseptica which affects gilthead seabream ( Sparus aurata ) and turbot ( Scophthalmus maximus ) ; and flexibacteriosis caused by Tenacibaculum maritimum which became a devastating problem in the emerging culture of sole ( Solea spp ) .',
  'Fat accumulation in the mesenteric adipose tissue is a serious problem in grass carp ( Ctenopharyngodon idella ) culture .',
  'An epidemic of tremor disease of Chinese mitten crabs , Eriocheir sinensis , has become a serious problem in recent years .',
  'Despite the ignorance about naturally occurring zebrafish viruses , zebrafish models are rapidly expanding in areas of biomedical research where the confounding effects of unknown infectious agents present a serious concern .',
  'Economic loss due to viral endothelial cell necrosis of eel ( VECNE ) of Anguilla japonica is a serious problem for the cultured Japanese eel market .',
  'It was concluded that the tensile test method developed provides an important addition to the available tools for mechanical analysis of salmon quality , particularly with respect to the prediction of gaping during factory processing , which is a serious commercial problem .',
  'Bacterial infections are a serious problem in aquaculture since they can result in massive mortalities in farmed fish and invertebrates .',
  'Outbreaks of koi herpesvirus ( KHV ) infection in carp are still a serious problem worldwide .',
  'Limited availability of sustainable feed ingredients is a serious concern in salmon aquaculture .',
  'Bacterial cold water disease in the ayu Plecoglossus altivelis caused by Flavobacterium psychrophilum is a serious problem in the Japanese freshwater culture industry .',
  'Recent outbreaks of AHPND in Asia have been causing great losses for shrimp culture and have become a serious socioeconomic problem .',
  'Estuarine tapertail anchovy ( Coilia nasus , junior synonym C. ectenes ) is a widely distributed and commercially important aquaculture species , although its growth in aquaculture settings is so slow as to pose a serious practical problem .',
  'Viral diseases represent a serious problem in Atlantic salmon ( Salmo salar L. ) farming in Norway .',
  'Streptococcus iniae infection has emerged as a serious fish health and economic problem in the global aquaculture operations .',
  'Fishborne zoonotic trematode ( FZT ) parasites are a serious food safety problem in Asian countries because of their tradition of eating raw fish .',
  'Over the last three decades , the causative agent of viral encephalopathy and retinopathy ( VER ) disease has become a serious problem of marine finfish aquaculture , and more recently the disease has also been associated with farmed freshwater fish .',
  'White tail disease ( WTD ) is a serious problem in Macrobrachium rosenbergii hatcheries and nursery ponds in Asia .',
  'White coloration of the muscle of the giant river prawn ( Macrobrachium rosenbergii ) is a serious problem in China .',
  'Infections with koi herpesvirus ( KHV ) in carp are still a severe problem worldwide .',
  'Reduction in eel resources and catches of glass eels as seedlings for aquaculture have been a serious concern in recent years in both Europe and East Asia .',
  'Grass carp ( Ctenopharyngodon idella ) hemorrhagic disease , caused by grass carp reovirus ( GCRV ) , has been a serious problem in grass carp aquaculture for several decades .',
  'Systemic tetrahymenosis caused by the protozoan parasite Tetrahymena spp . is a serious problem in guppy ( Poecilia reticulata ) farms worldwide .',
  'White tail disease ( WTD ) , caused by Macrobrachium rosenbergii nodavirus ( MrNV ) , is a serious problem in farm cultivation and is responsible for up to 100 % mortality in the post larvae stage .',
  'L. branchialis is recognised as a pathogen that could have major effects on the aquaculture industry and with gadoid ( especially cod ) farming expanding in several North Atlantic countries , there is considerable potential for this parasite to become a serious problem for commercial mariculture .',
  'In conclusion , the observed malformations are considered a sign for a severe health problem and therefore a risk for the successful breeding of allis shad in aquaculture .',
  'White tail disease ( WTD ) is a serious problem in hatcheries and nursery ponds of Macrobrachium rosenbergii in India and many parts of the world .',
  'Bacterial cold water disease , caused by Flavobacterium psychrophilum , is a serious problem in the aquaculture industry worldwide .',
  'Pet turtle-associated salmonellosis was recognized as a serious public health problem in the 1960s and 1970s , and in February 1975 legislation banning the importation of turtles into Canada was enacted by Agriculture Canada .',
  'Infections by the gill fluke Zeuxapta seriolae are a serious concern for sea cage aquaculture of kingfish , Seriola lalandi .',
  'Rapid sexual maturity of female Macrobrachium nipponense is a severe problem for the aquaculture industry .',
  'Systemic tetrahymenosis constitutes a serious problem in guppy ( Poecilia reticulata ) production worldwide and no therapeutic solution is available for this disease .',
  'Iridovirus infections remain a severe problem in aquaculture industries worldwide .',
  'Infectious diseases are a serious problem and a major contributor to severe economic losses in intensive fish culture .',
  'The bacterium Flavobacterium psychrophilum is a serious problem for salmonid farming worldwide .',
  'Parasitic infections caused by Tetrahymena sp. constitute a serious problem in guppies , Poecilia reticulata .',
  'Antibacterial and antiparasitic agents and a cysteine protease inhibitor ( E-64 ) were tested against Tetrahymena infection , a serious problem in guppy production worldwide .',
  'Ulcer disease , caused by atypical Aeromonas salmonicida , is a serious concern in ornamental koi carp , because it induces skin ulceration , disfiguring ornamental fish and causing economic loses .',
  'The emergence of drug-resistant bacteria is a severe problem in aquaculture .',
  'Columnaris disease caused by Flavobacterium columnare is a serious problem in aquaculture , annually causing large economic losses around the world .'],
 'carp': ['Columnaris disease has long been recognized as a serious problem worldwide which affects both wild and cultured freshwater fish including the commercially important channel catfish ( Ictalurus punctatus ) .',
  'Ascidian soft tunic syndrome ( AsSTS ) caused by Azumiobodo hoyamushi ( A. hoyamushi ) is a serious aquaculture problem that results in mass mortality of ascidians .',
  'An infection of pearl oysters , Pinctada maxima , attributed to a Haplosporidium sp. by Hine and Thorne ( 1998 ) has been detected on 3 occasions and is considered to represent a serious concern to the pearling industry in Australia .',
  'Bacterial infection in the marine environment is a serious problem to maintain the stability of marine ecosystems .',
  'Gray mullet ( Mugilidae ) occur in all seas and are farmed widely around the world , and thus , the risk of their parasites spreading through transport of aquaculture seed is a serious concern .',
  'Melanin accumulations in ectopic locations , in particular muscle , represent a serious quality problem in salmon production .',
  'Grass carp ( Ctenopharyngodon idella ) hemorrhagic disease , caused by grass carp reovirus ( GCRV ) , is emerging as a serious problem in grass carp aquaculture .',
  'During the past decades , Vibrio spp . infections have been a serious problem that causes fish blight and very large economic losses , especially in China , Japan , Europe , and North America .',
  "The infectious kinetoplastid Azumiobodo hoyamushi causes ' soft tunic syndrome ' , a serious problem in aquaculture of the edible ascidian Halocynthia roretzi .",
  'Disease-induced mortality of juvenile salmon has become a serious concern in recent years .',
  'It is suggested that THV infection is not a serious problem for the Chinese soft-shelled turtle culture in this region .',
  'Grass carp ( Ctenopharyngodon idella ) hemorrhagic disease , caused by grass carp reovirus ( GCRV ) , is emerging as a serious problem in grass carp aquaculture .',
  'White tail disease ( WTD ) is a serious problem in hatcheries and nursery ponds of Macrobrachium rosenbergii in India .',
  'The marine white spot disease caused by protozoan ectoparasite Cryptocaryon irritans is a severe problem to the large yellow croaker farming industry .',
  'White tail disease ( WTD ) was found to be a serious problem in hatcheries and nursery ponds of Macrobrachium rosenbergii in India .',
  'White tail disease ( WTD ) caused by Macrobrachium rosenbergii nodavirus ( MrNV ) and extra small virus ( XSV ) is a serious problem in prawn hatcheries .',
  'These are lactococcosis caused by Lactococcus garvieae , which is of economical importance in rainbow trout ( Oncorhynchus mykiss ) ; pseudomonadiasis caused by Pseudomonas anguilliseptica which affects gilthead seabream ( Sparus aurata ) and turbot ( Scophthalmus maximus ) ; and flexibacteriosis caused by Tenacibaculum maritimum which became a devastating problem in the emerging culture of sole ( Solea spp ) .',
  'Fat accumulation in the mesenteric adipose tissue is a serious problem in grass carp ( Ctenopharyngodon idella ) culture .',
  'An epidemic of tremor disease of Chinese mitten crabs , Eriocheir sinensis , has become a serious problem in recent years .',
  'Despite the ignorance about naturally occurring zebrafish viruses , zebrafish models are rapidly expanding in areas of biomedical research where the confounding effects of unknown infectious agents present a serious concern .',
  'Economic loss due to viral endothelial cell necrosis of eel ( VECNE ) of Anguilla japonica is a serious problem for the cultured Japanese eel market .',
  'It was concluded that the tensile test method developed provides an important addition to the available tools for mechanical analysis of salmon quality , particularly with respect to the prediction of gaping during factory processing , which is a serious commercial problem .',
  'Bacterial infections are a serious problem in aquaculture since they can result in massive mortalities in farmed fish and invertebrates .',
  'Outbreaks of koi herpesvirus ( KHV ) infection in carp are still a serious problem worldwide .',
  'Limited availability of sustainable feed ingredients is a serious concern in salmon aquaculture .',
  'Bacterial cold water disease in the ayu Plecoglossus altivelis caused by Flavobacterium psychrophilum is a serious problem in the Japanese freshwater culture industry .',
  'Recent outbreaks of AHPND in Asia have been causing great losses for shrimp culture and have become a serious socioeconomic problem .',
  'Estuarine tapertail anchovy ( Coilia nasus , junior synonym C. ectenes ) is a widely distributed and commercially important aquaculture species , although its growth in aquaculture settings is so slow as to pose a serious practical problem .',
  'Viral diseases represent a serious problem in Atlantic salmon ( Salmo salar L. ) farming in Norway .',
  'Streptococcus iniae infection has emerged as a serious fish health and economic problem in the global aquaculture operations .',
  'Fishborne zoonotic trematode ( FZT ) parasites are a serious food safety problem in Asian countries because of their tradition of eating raw fish .',
  'Over the last three decades , the causative agent of viral encephalopathy and retinopathy ( VER ) disease has become a serious problem of marine finfish aquaculture , and more recently the disease has also been associated with farmed freshwater fish .',
  'White tail disease ( WTD ) is a serious problem in Macrobrachium rosenbergii hatcheries and nursery ponds in Asia .',
  'White coloration of the muscle of the giant river prawn ( Macrobrachium rosenbergii ) is a serious problem in China .',
  'Infections with koi herpesvirus ( KHV ) in carp are still a severe problem worldwide .',
  'Reduction in eel resources and catches of glass eels as seedlings for aquaculture have been a serious concern in recent years in both Europe and East Asia .',
  'Grass carp ( Ctenopharyngodon idella ) hemorrhagic disease , caused by grass carp reovirus ( GCRV ) , has been a serious problem in grass carp aquaculture for several decades .',
  'Systemic tetrahymenosis caused by the protozoan parasite Tetrahymena spp . is a serious problem in guppy ( Poecilia reticulata ) farms worldwide .',
  'White tail disease ( WTD ) , caused by Macrobrachium rosenbergii nodavirus ( MrNV ) , is a serious problem in farm cultivation and is responsible for up to 100 % mortality in the post larvae stage .',
  'L. branchialis is recognised as a pathogen that could have major effects on the aquaculture industry and with gadoid ( especially cod ) farming expanding in several North Atlantic countries , there is considerable potential for this parasite to become a serious problem for commercial mariculture .',
  'In conclusion , the observed malformations are considered a sign for a severe health problem and therefore a risk for the successful breeding of allis shad in aquaculture .',
  'White tail disease ( WTD ) is a serious problem in hatcheries and nursery ponds of Macrobrachium rosenbergii in India and many parts of the world .',
  'Bacterial cold water disease , caused by Flavobacterium psychrophilum , is a serious problem in the aquaculture industry worldwide .',
  'Pet turtle-associated salmonellosis was recognized as a serious public health problem in the 1960s and 1970s , and in February 1975 legislation banning the importation of turtles into Canada was enacted by Agriculture Canada .',
  'Infections by the gill fluke Zeuxapta seriolae are a serious concern for sea cage aquaculture of kingfish , Seriola lalandi .',
  'Rapid sexual maturity of female Macrobrachium nipponense is a severe problem for the aquaculture industry .',
  'Systemic tetrahymenosis constitutes a serious problem in guppy ( Poecilia reticulata ) production worldwide and no therapeutic solution is available for this disease .',
  'Iridovirus infections remain a severe problem in aquaculture industries worldwide .',
  'Infectious diseases are a serious problem and a major contributor to severe economic losses in intensive fish culture .',
  'The bacterium Flavobacterium psychrophilum is a serious problem for salmonid farming worldwide .',
  'Parasitic infections caused by Tetrahymena sp. constitute a serious problem in guppies , Poecilia reticulata .',
  'Antibacterial and antiparasitic agents and a cysteine protease inhibitor ( E-64 ) were tested against Tetrahymena infection , a serious problem in guppy production worldwide .',
  'Ulcer disease , caused by atypical Aeromonas salmonicida , is a serious concern in ornamental koi carp , because it induces skin ulceration , disfiguring ornamental fish and causing economic loses .',
  'The emergence of drug-resistant bacteria is a severe problem in aquaculture .',
  'Columnaris disease caused by Flavobacterium columnare is a serious problem in aquaculture , annually causing large economic losses around the world .'],
 'mastitis': ['Intramammary infections are a serious problem for dairy sheep farms , and Staphylococcus epidermidis is one of the main etiological agents of ovine mastitis .',
  'Bovine mastitis caused by Prototheca is a serious and complex problem that accounts for high economic losses in the dairy industry .',
  'The trial showed that the vaccine was efficacious in reducing the incidence of clinical mastitis and prevalence of subclinical mastitis in a herd that had a serious staphylococcal mastitis problem .',
  'Mastitis is a serious problem in dairy sector and among various aetiological agents , the incidence of staphylococci and streptococci remains high in milking animal .',
  'Endometritis in dairy cow herds is a serious economic problem all over the world due to the large economic losses .',
  'The authors feel strongly that this work identifies a serious and ill-defined problem in the management of neonatal calves .',
  'Mastitis is a severe problem in humans and other animals and is characterized by mammary gland cell apoptosis .',
  'Oxidative stress in the mammary gland of high-yielding dairy cows is a serious problem .',
  'Mastitis , either subclinical or clinical , did not appear to be a serious problem in this particular flock .',
  'Methicillin-resistant Staphylococcus aureus ( MRSA ) poses a serious problem in dairy animals suffering from mastitis .',
  'A severe mastitis problem associated with Cryptococcus neoformans in a large dairy herd .',
  'Herds had been participating for 15 or 22 yr in mastitis control programs against Streptococcus agalactiae and Staphylococcus aureus , had low bulk tank SCC , and had maintained good standards of hygiene and husbandry , but clinical mastitis remained a serious problem .',
  'Sheep of four flocks ( group A ) , in which insufficient lamb growth apparently associated with insufficient milk production and probably related to udder induration , was a serious problem , were clinically examined in mid-lactation .',
  'Coliform mastitis ( CM ) is not only a serious economical and animal welfare touching problem in dairy cattle , but also in sows after farrowing .',
  'Colic in camelids is considered a severe problem because clinical signs are subtle and often not recognized until the condition is untreatable .',
  'E. coli mastitis can be a severe problem during the beginning of lactation whereas it is completely self-curing after peak lactation ( 8 weeks ) .',
  'Digital dermatitis is a serious problem in dairy production in many countries .',
  'Poor udder health represents a serious problem in dairy production and has been investigated intensively , but heifers generally have not been the main focus of mastitis control .',
  'Reproductive diseases after parturition are a serious problem in dairy cattle .',
  'The present data suggest that the effects of calf breed do not place a serious problem on the economic traits of Holstein dams .',
  'The incidence of attacking or avoiding calves is greater among heifers than among older cows and rejection is occasionally a serious problem .',
  'Bovine mastitis caused by Staphylococcus aureus is a serious problem in dairy production and effective immunoprophylaxis is an unmet goal so far .',
  'Mastitis is a serious problem for sheep and rabbit farms , Staphylococcus aureus being the main causal agent .',
  'Pyometra is a serious problem in dairy cow herds , causing large economic losses due to infertility .',
  'Mastitis is an important animal health disease which constitutes a serious problem for the dairy industry in New Zealand .',
  'In dairy cow herds , mastitis is a serious problem .',
  'Uterine torsion appears to be a serious problem in buffaloes that has certain peculiarities including time of occurrence , site and direction of torsion , and the high mortality rates .',
  'Mastitis poses a serious problem for humans and animals in the postpartum period .',
  'Bovine digital dermatitis ( DD ) is a severe infectious disease causing lameness in dairy cattle worldwide and is an important ruminant welfare problem that has considerable economic issues .',
  'The detection of mastitis caused by Prototheca sp. indicates a serious problem which can affect an entire herd .',
  'Bovine mastitis caused by the yeast-like alga Prototheca zopfii represents a serious veterinary problem and may result in heavy economic losses to particular dairy farms .',
  'Calf mortality generally occurs in calves prior to weaning , which is a serious problem in cattle breeding .',
  'Hormone treatment promotes calving ease with a markedly reduced incidence of the detrimental effects of dystocia , which may be a serious problem in first-calf heifers .'],
 'stis': ['Available evidence indicates that STDs are a serious problem among adolescents ( 10 - 19 years ) , especially in rural areas where services are limited for any age group .',
  'Although they may or may not pose a serious public health problem , as markers of misguided or exploitative gender relations they do reveal important aspects of social psychology related to sexuality and sexual health .',
  'Since sexually transmitted diseases ( STDs ) are a serious health problem among youth , proper understanding of knowledge about STDs , beliefs about condom use and associated factors are public health necessities .',
  'The STDs in children are a worrisome problem .',
  "Both ' call girls ' ( private sex workers ) and brothel workers were infected with sexually transmitted diseases as often in their noncommercial sexual relations as in their work , smoking was a serious problem for both , and each group endured problems from clients specific to their work sites .",
  'The Huli of the Tari Basin have a serious problem with the spread of STDs following the opening of the Highlands Highway from Mendi in the early 1980s .',
  'Sexually transmitted diseases in tropical Africa are a severe problem .',
  'Sexually transmitted infections ( STIs ) remains a serious healthcare problem costing approximately 13 billion dollars annually to treat .',
  'As for several other infectious diseases , sexually transmitted diseases ( STD ) in many developing countries are characterized by a high incidence and prevalence , a high rate of complications and sequelae ( particularly in women and neonates ) , a different clinical spectrum ( more genital ulcer disease ) , and a severe problem of antimicrobial resistance ( in N. gonorrhoeae and C. trachomatis ) .',
  'The disease burden of classic sexually transmitted infections has historically been heavy , and continues to be a serious public health problem in South Africa .',
  'However , participants acknowledged that STIs are a serious problem and recommended strategies for increasing participation in an STI testing and treatment programme .',
  'Risky sexual behavior is a serious public health problem .',
  'There is an urgent need for the recognition of sexually transmitted infections ( STIs ) as a serious public health problem in Europe .',
  'Genital chlamydial infection , with its possible long-term morbidity , is a serious public health problem .',
  'Chlamydia trachomatis infection is a serious public health concern that disproportionately affects adolescent girls .',
  'Sexually transmitted infections are a serious public health concern worldwide , especially in young people .',
  'STIs are a serious public health problem .',
  'Chlamydial disease in adolescent women is a serious public health problem , but secondary preventive efforts through early detection and treatment are encumbered by the cost and complexity of mass screening .',
  'Sexually transmitted Chlamydia trachomatis infections are a serious public-health problem .',
  'Sexually transmitted infections ( STIs ) are a serious public health problem in low income countries , including Ethiopia .',
  'Sexually transmitted infections ( STIs ) are considered a serious public health problem worldwide , affecting especially young people .',
  'Chlamydia trachomatis is now one of the most prevalent bacteria found in classic sexually transmissible diseases ( STD ) , and as such , constitutes a serious public health problem .',
  'Avian chlamydiosis ( AC ) can be economically devastating to producers and a serious public health problem .',
  'This study indicates that raising awareness of chlamydia as a serious sexual health problem may not be the best way to increase the uptake of testing in a high-risk population .',
  'Sexually transmitted diseases are becoming a serious public health problem in China .',
  'Sexually transmitted diseases ( STDs ) are a serious health problem for adolescents , occurring in an estimated one-quarter of sexually active teen-agers .',
  'Sexually transmitted infections are a serious health problem in Honduras .',
  'Sexually transmitted infections ( STIs ) pose a serious public health problem globally .',
  'Our results suggest that STIs are a serious problem in Mongolia .',
  'Sexually transmitted infections ( STIs ) are a serious global health problem .',
  'Contracting sexually transmitted diseases is a serious health problem faced by young women , in part , because they may routinely engage in risky sexual behaviors .',
  'Sexually Transmitted Diseases are still considered a serious public health problem in Brazil and worldwide .',
  'Sexually transmitted infections are a serious public health problem .'],
 'stds': ['Available evidence indicates that STDs are a serious problem among adolescents ( 10 - 19 years ) , especially in rural areas where services are limited for any age group .',
  'Although they may or may not pose a serious public health problem , as markers of misguided or exploitative gender relations they do reveal important aspects of social psychology related to sexuality and sexual health .',
  'Since sexually transmitted diseases ( STDs ) are a serious health problem among youth , proper understanding of knowledge about STDs , beliefs about condom use and associated factors are public health necessities .',
  'The STDs in children are a worrisome problem .',
  "Both ' call girls ' ( private sex workers ) and brothel workers were infected with sexually transmitted diseases as often in their noncommercial sexual relations as in their work , smoking was a serious problem for both , and each group endured problems from clients specific to their work sites .",
  'The Huli of the Tari Basin have a serious problem with the spread of STDs following the opening of the Highlands Highway from Mendi in the early 1980s .',
  'Sexually transmitted diseases in tropical Africa are a severe problem .',
  'Sexually transmitted infections ( STIs ) remains a serious healthcare problem costing approximately 13 billion dollars annually to treat .',
  'As for several other infectious diseases , sexually transmitted diseases ( STD ) in many developing countries are characterized by a high incidence and prevalence , a high rate of complications and sequelae ( particularly in women and neonates ) , a different clinical spectrum ( more genital ulcer disease ) , and a severe problem of antimicrobial resistance ( in N. gonorrhoeae and C. trachomatis ) .',
  'The disease burden of classic sexually transmitted infections has historically been heavy , and continues to be a serious public health problem in South Africa .',
  'However , participants acknowledged that STIs are a serious problem and recommended strategies for increasing participation in an STI testing and treatment programme .',
  'Risky sexual behavior is a serious public health problem .',
  'There is an urgent need for the recognition of sexually transmitted infections ( STIs ) as a serious public health problem in Europe .',
  'Genital chlamydial infection , with its possible long-term morbidity , is a serious public health problem .',
  'Chlamydia trachomatis infection is a serious public health concern that disproportionately affects adolescent girls .',
  'Sexually transmitted infections are a serious public health concern worldwide , especially in young people .',
  'STIs are a serious public health problem .',
  'Chlamydial disease in adolescent women is a serious public health problem , but secondary preventive efforts through early detection and treatment are encumbered by the cost and complexity of mass screening .',
  'Sexually transmitted Chlamydia trachomatis infections are a serious public-health problem .',
  'Sexually transmitted infections ( STIs ) are a serious public health problem in low income countries , including Ethiopia .',
  'Sexually transmitted infections ( STIs ) are considered a serious public health problem worldwide , affecting especially young people .',
  'Chlamydia trachomatis is now one of the most prevalent bacteria found in classic sexually transmissible diseases ( STD ) , and as such , constitutes a serious public health problem .',
  'Avian chlamydiosis ( AC ) can be economically devastating to producers and a serious public health problem .',
  'This study indicates that raising awareness of chlamydia as a serious sexual health problem may not be the best way to increase the uptake of testing in a high-risk population .',
  'Sexually transmitted diseases are becoming a serious public health problem in China .',
  'Sexually transmitted diseases ( STDs ) are a serious health problem for adolescents , occurring in an estimated one-quarter of sexually active teen-agers .',
  'Sexually transmitted infections are a serious health problem in Honduras .',
  'Sexually transmitted infections ( STIs ) pose a serious public health problem globally .',
  'Our results suggest that STIs are a serious problem in Mongolia .',
  'Sexually transmitted infections ( STIs ) are a serious global health problem .',
  'Contracting sexually transmitted diseases is a serious health problem faced by young women , in part , because they may routinely engage in risky sexual behaviors .',
  'Sexually Transmitted Diseases are still considered a serious public health problem in Brazil and worldwide .',
  'Sexually transmitted infections are a serious public health problem .'],
 'chlamydia': ['Available evidence indicates that STDs are a serious problem among adolescents ( 10 - 19 years ) , especially in rural areas where services are limited for any age group .',
  'Although they may or may not pose a serious public health problem , as markers of misguided or exploitative gender relations they do reveal important aspects of social psychology related to sexuality and sexual health .',
  'Since sexually transmitted diseases ( STDs ) are a serious health problem among youth , proper understanding of knowledge about STDs , beliefs about condom use and associated factors are public health necessities .',
  'The STDs in children are a worrisome problem .',
  "Both ' call girls ' ( private sex workers ) and brothel workers were infected with sexually transmitted diseases as often in their noncommercial sexual relations as in their work , smoking was a serious problem for both , and each group endured problems from clients specific to their work sites .",
  'The Huli of the Tari Basin have a serious problem with the spread of STDs following the opening of the Highlands Highway from Mendi in the early 1980s .',
  'Sexually transmitted diseases in tropical Africa are a severe problem .',
  'Sexually transmitted infections ( STIs ) remains a serious healthcare problem costing approximately 13 billion dollars annually to treat .',
  'As for several other infectious diseases , sexually transmitted diseases ( STD ) in many developing countries are characterized by a high incidence and prevalence , a high rate of complications and sequelae ( particularly in women and neonates ) , a different clinical spectrum ( more genital ulcer disease ) , and a severe problem of antimicrobial resistance ( in N. gonorrhoeae and C. trachomatis ) .',
  'The disease burden of classic sexually transmitted infections has historically been heavy , and continues to be a serious public health problem in South Africa .',
  'However , participants acknowledged that STIs are a serious problem and recommended strategies for increasing participation in an STI testing and treatment programme .',
  'Risky sexual behavior is a serious public health problem .',
  'There is an urgent need for the recognition of sexually transmitted infections ( STIs ) as a serious public health problem in Europe .',
  'Genital chlamydial infection , with its possible long-term morbidity , is a serious public health problem .',
  'Chlamydia trachomatis infection is a serious public health concern that disproportionately affects adolescent girls .',
  'Sexually transmitted infections are a serious public health concern worldwide , especially in young people .',
  'STIs are a serious public health problem .',
  'Chlamydial disease in adolescent women is a serious public health problem , but secondary preventive efforts through early detection and treatment are encumbered by the cost and complexity of mass screening .',
  'Sexually transmitted Chlamydia trachomatis infections are a serious public-health problem .',
  'Sexually transmitted infections ( STIs ) are a serious public health problem in low income countries , including Ethiopia .',
  'Sexually transmitted infections ( STIs ) are considered a serious public health problem worldwide , affecting especially young people .',
  'Chlamydia trachomatis is now one of the most prevalent bacteria found in classic sexually transmissible diseases ( STD ) , and as such , constitutes a serious public health problem .',
  'Avian chlamydiosis ( AC ) can be economically devastating to producers and a serious public health problem .',
  'This study indicates that raising awareness of chlamydia as a serious sexual health problem may not be the best way to increase the uptake of testing in a high-risk population .',
  'Sexually transmitted diseases are becoming a serious public health problem in China .',
  'Sexually transmitted diseases ( STDs ) are a serious health problem for adolescents , occurring in an estimated one-quarter of sexually active teen-agers .',
  'Sexually transmitted infections are a serious health problem in Honduras .',
  'Sexually transmitted infections ( STIs ) pose a serious public health problem globally .',
  'Our results suggest that STIs are a serious problem in Mongolia .',
  'Sexually transmitted infections ( STIs ) are a serious global health problem .',
  'Contracting sexually transmitted diseases is a serious health problem faced by young women , in part , because they may routinely engage in risky sexual behaviors .',
  'Sexually Transmitted Diseases are still considered a serious public health problem in Brazil and worldwide .',
  'Sexually transmitted infections are a serious public health problem .'],
 'fetal': ['Data from this study showed that exposure to medication is a serious health problem for women of reproductive age and it contributes to the increase in the number of hospitalizations .',
  'Substance abuse during pregnancy continues to be a serious health problem in the United States .',
  'Use of alcohol and drugs during pregnancy is regarded as a serious problem in the medical field .',
  'Fetal Alcohol Syndrome ( FAS ) has been recognized as a serious developmental problem occurring in some offspring of alcoholic women .',
  "We use data from the Fragile Families and Child Wellbeing Study , augmented with information from hospital medical records , to estimate the effects of the birth of a child with a severe health problem on the likelihood that the infant 's father engages in illegal activities .",
  'Illicit drug use during pregnancy is a serious social and public health problem inflicting an array of deleterious effects on both mother and offspring .',
  'Foetal exposure to maternally administered opiates such as morphine represent a serious human health problem but disposition studies in man are difficult to perform .',
  'The lack of information needed to assess the safety of drug treatments during human pregnancy remains a serious public health problem .',
  'Cocaine addiction is a serious health problem for pregnant women and their babies .',
  'The mass incarceration of pregnant and parenting women is a serious problem in U.S. A policy focus is needed that takes a public health approach .',
  'The excessive intake of alcohol is a serious public health problem , especially given the severe damage provoked by chronic or prenatal exposure to alcohol that affects many physiological processes , such as memory , motor function , and cognitive abilities .',
  'Drinking alcohol in pregnancy is a serious public health concern worldwide .',
  'This conservative rate -- nearly one in every 100 live births -- confirms the perception of many health professionals that fetal alcohol exposure is a serious problem .',
  'Drug of abuse consumption throughout pregnancy is a serious public health problem and an important economic cost to the health system .',
  'The use of addictive substances during pregnancy is a serious social problem , not only because of effects on the health of the woman and child , but also because drug or alcohol dependency detracts from child care and enhances the prospect of child neglect and family breakdown .',
  'Drinking alcohol in pregnancy is of a serious public health concern worldwide .',
  'Maternal substance abuse is a serious problem with significant adverse effects to mothers , fetuses , and children .',
  'Fetal alcohol exposure is a serious social and public health problem .',
  'Prenatal alcohol exposure ( PAE ) continues to be a serious public health problem , yet no reliable clinical tools are available for assessing levels of drinking during pregnancy .',
  'Fetal alcohol syndrome ( FAS ) is a serious global health problem and is observed at high frequencies in certain South African communities .',
  'Fetal exposure to alcohol is a serious public health problem and is associated with anomalies of the eye ground , as well as neurodevelopmental delay , growth delay , and characteristic facial features .',
  'Fetal drug addiction is a serious public health problem .',
  'A serious problem is the evaluation of retrospective drug risks in cases of drugs administered before pregnancy was confirmed .',
  'Fetal alcohol spectrum disorder ( FASD ) is a serious and widespread problem in this country .',
  'A variety of public education programs developed over the last 20 years have promoted alcohol abstention during pregnancy , yet FASD remains a serious public health concern .',
  'The growing number of pregnant women using illicit substances presents a serious public health concern .',
  'Consumption of drugs of abuse , tobacco and alcohol throughout pregnancy is a serious public health problem and results in an important economic cost to the health system .',
  'Heroin abuse during pregnancy is a serious problem worldwide .',
  'Drug abuse by pregnant women is considered a serious public health problem worldwide .',
  'Hence , alterations in its activity caused by the transfer of maternal drugs over a prolonged period of time could pose a serious problem to nurslings when they require drugs for their own benefit .'],
 'adulteration': ['Food and beverage deterioration by spoilage yeasts is a serious problem that causes substantial financial losses each year .',
  'Adulteration by using SS ( beet sugar ) still has a serious detection problem , especially in countries in which beet is used in manufacturing sugar .',
  'Food spoilage is a serious problem in the food industry , since it leads to significant economic losses .',
  'The presence of Alicyclobacillus acidoterrestris , a thermoacidophilic and spore-forming bacterium , in pasteurized acidic juices poses a serious problem for the processing industry .',
  'Adulteration of foods is a serious economic problem concerning most foodstuffs , and in particular meat products .',
  'Protein fouling is a serious problem in many food , pharmaceutical and household industries .',
  'Food spoilage and its contamination with yeast and mold is a serious problem of food industry .',
  'Food spoilage represents a severe problem for food manufacturers .',
  'The presence of Alicyclobacillus in fruit juices and concentrates poses a serious problem for the juice industry .',
  'Moreover , adulteration of rice is a serious problem for consumers .',
  'The presence of Alicyclobacillus , a thermoacidophilic and spore-forming bacterium , in acidic fruit juices poses a serious problem for the processing industry .',
  'PRACTICAL APPLICATION : Coffee adulteration is a serious problem in the food chain as some fraudsters replace coffee powder by other cheaper products .',
  "During the products storage time , concentrations of preservative(s ) are decreasing , which may eventually cause a serious problem in the food 's microbial safety .",
  'Yeast contamination is a serious problem in the food industry and a major cause of food spoilage .',
  'Meat adulteration is a serious problem in the meat industry and needs to be tackled to ensure the authenticity of meat products and protect the consumers from being the victims .',
  'Food adulteration is a serious social problem all over the world .',
  'The oxidation of lipids in different prefabricated meat products may have detrimental effects on the organoleptic properties and/or safety of meat , and poses a serious health concern .'],
 'alicyclobacillus': ['Food and beverage deterioration by spoilage yeasts is a serious problem that causes substantial financial losses each year .',
  'Adulteration by using SS ( beet sugar ) still has a serious detection problem , especially in countries in which beet is used in manufacturing sugar .',
  'Food spoilage is a serious problem in the food industry , since it leads to significant economic losses .',
  'The presence of Alicyclobacillus acidoterrestris , a thermoacidophilic and spore-forming bacterium , in pasteurized acidic juices poses a serious problem for the processing industry .',
  'Adulteration of foods is a serious economic problem concerning most foodstuffs , and in particular meat products .',
  'Protein fouling is a serious problem in many food , pharmaceutical and household industries .',
  'Food spoilage and its contamination with yeast and mold is a serious problem of food industry .',
  'Food spoilage represents a severe problem for food manufacturers .',
  'The presence of Alicyclobacillus in fruit juices and concentrates poses a serious problem for the juice industry .',
  'Moreover , adulteration of rice is a serious problem for consumers .',
  'The presence of Alicyclobacillus , a thermoacidophilic and spore-forming bacterium , in acidic fruit juices poses a serious problem for the processing industry .',
  'PRACTICAL APPLICATION : Coffee adulteration is a serious problem in the food chain as some fraudsters replace coffee powder by other cheaper products .',
  "During the products storage time , concentrations of preservative(s ) are decreasing , which may eventually cause a serious problem in the food 's microbial safety .",
  'Yeast contamination is a serious problem in the food industry and a major cause of food spoilage .',
  'Meat adulteration is a serious problem in the meat industry and needs to be tackled to ensure the authenticity of meat products and protect the consumers from being the victims .',
  'Food adulteration is a serious social problem all over the world .',
  'The oxidation of lipids in different prefabricated meat products may have detrimental effects on the organoleptic properties and/or safety of meat , and poses a serious health concern .'],
 'juices': ['Food and beverage deterioration by spoilage yeasts is a serious problem that causes substantial financial losses each year .',
  'Adulteration by using SS ( beet sugar ) still has a serious detection problem , especially in countries in which beet is used in manufacturing sugar .',
  'Food spoilage is a serious problem in the food industry , since it leads to significant economic losses .',
  'The presence of Alicyclobacillus acidoterrestris , a thermoacidophilic and spore-forming bacterium , in pasteurized acidic juices poses a serious problem for the processing industry .',
  'Adulteration of foods is a serious economic problem concerning most foodstuffs , and in particular meat products .',
  'Protein fouling is a serious problem in many food , pharmaceutical and household industries .',
  'Food spoilage and its contamination with yeast and mold is a serious problem of food industry .',
  'Food spoilage represents a severe problem for food manufacturers .',
  'The presence of Alicyclobacillus in fruit juices and concentrates poses a serious problem for the juice industry .',
  'Moreover , adulteration of rice is a serious problem for consumers .',
  'The presence of Alicyclobacillus , a thermoacidophilic and spore-forming bacterium , in acidic fruit juices poses a serious problem for the processing industry .',
  'PRACTICAL APPLICATION : Coffee adulteration is a serious problem in the food chain as some fraudsters replace coffee powder by other cheaper products .',
  "During the products storage time , concentrations of preservative(s ) are decreasing , which may eventually cause a serious problem in the food 's microbial safety .",
  'Yeast contamination is a serious problem in the food industry and a major cause of food spoilage .',
  'Meat adulteration is a serious problem in the meat industry and needs to be tackled to ensure the authenticity of meat products and protect the consumers from being the victims .',
  'Food adulteration is a serious social problem all over the world .',
  'The oxidation of lipids in different prefabricated meat products may have detrimental effects on the organoleptic properties and/or safety of meat , and poses a serious health concern .'],
 'products': ['Food and beverage deterioration by spoilage yeasts is a serious problem that causes substantial financial losses each year .',
  'Adulteration by using SS ( beet sugar ) still has a serious detection problem , especially in countries in which beet is used in manufacturing sugar .',
  'Food spoilage is a serious problem in the food industry , since it leads to significant economic losses .',
  'The presence of Alicyclobacillus acidoterrestris , a thermoacidophilic and spore-forming bacterium , in pasteurized acidic juices poses a serious problem for the processing industry .',
  'Adulteration of foods is a serious economic problem concerning most foodstuffs , and in particular meat products .',
  'Protein fouling is a serious problem in many food , pharmaceutical and household industries .',
  'Food spoilage and its contamination with yeast and mold is a serious problem of food industry .',
  'Food spoilage represents a severe problem for food manufacturers .',
  'The presence of Alicyclobacillus in fruit juices and concentrates poses a serious problem for the juice industry .',
  'Moreover , adulteration of rice is a serious problem for consumers .',
  'The presence of Alicyclobacillus , a thermoacidophilic and spore-forming bacterium , in acidic fruit juices poses a serious problem for the processing industry .',
  'PRACTICAL APPLICATION : Coffee adulteration is a serious problem in the food chain as some fraudsters replace coffee powder by other cheaper products .',
  "During the products storage time , concentrations of preservative(s ) are decreasing , which may eventually cause a serious problem in the food 's microbial safety .",
  'Yeast contamination is a serious problem in the food industry and a major cause of food spoilage .',
  'Meat adulteration is a serious problem in the meat industry and needs to be tackled to ensure the authenticity of meat products and protect the consumers from being the victims .',
  'Food adulteration is a serious social problem all over the world .',
  'The oxidation of lipids in different prefabricated meat products may have detrimental effects on the organoleptic properties and/or safety of meat , and poses a serious health concern .'],
 'pesticide': ['However , the undesired effects of chemical pesticides have been recognized as a serious public health concern during the past decades .',
  'The largely uncontrolled use of diverse pesticides led us to hypothesize that these agents , and particularly organochlorine compounds , may pose a serious problem in the Republic of Benin .',
  'These results show that , despite the high levels of some pesticide residues , they may not be considered as a serious public health problem .',
  'However , the pesticide levels found can not be considered a serious health problem according to results from other pesticide monitoring studies .',
  'The results indicate that the occurrence of pesticide residues in apples could not be considered a serious public health problem .',
  'Exposure to insecticides is a serious environmental problem owing to their cytotoxic effects in humans and animals .',
  'Intensive use of pesticides , especially insecticides , in agriculture during the past several decades has already led to contamination of surface and underground waters and sediments in some regions , thus presents a serious problem for the environment .',
  'This results show that the detected pesticides could not be considered a serious public health problem .',
  'Three of the main classes of pesticides that pose a serious problem are organochlorines , organophosphates and carbamates .',
  'Human poisoning by pesticides has long been seen as a severe public health problem .',
  'Pesticide contamination in Tajikistan is a serious and ongoing problem that requires the attention of local , state governments , and international non-governmental organizations .',
  'Presence of harmful pesticide residue in food is a serious cause for concern among consumers so it is important to monitor levels of pesticides in foods .',
  'Contamination with 1,2-unsaturated pyrrolizidine alkaloids ( PAs ) is a serious problem for certain phytomedicines , foods , and animal feeds .',
  'Global pollution from excessive pesticide use has become a serious environmental and public health problem .',
  'Pesticide poisonings in children continue to be a serious problem .',
  'Haphazard use of pesticides in the field and stored food commodities for the control of insect and pest has been a serious problem from view of environment and public health .',
  'The presence of pesticide residues in fruit is a serious health concern .',
  'Old , obsolete pesticide stocks are a vexing problem in numerous developing countries .',
  'In addition to water contamination , the presence of pesticide residues in food poses a risk to the population , being a serious public health problem in Brazil .',
  'The use of pesticides on cash crops and exportable food commodities had always been a serious concern .',
  'Agricultural pesticides used with the criminal intent to intoxicate domestic and wild animals are a serious concern in Veterinary Medicine .',
  'Pesticide residue in vegetables is a serious problem that has adverse effects on human health .',
  'In recent years , water pollution and pesticide accumulation in the food chain have become a serious environmental and health hazard problem .',
  'Exposure to pesticides has become a serious concern for the environment and human health .',
  'Exposure to toxic substances , including pesticides , can cause irreversible damage to humans , including death , and is therefore considered a serious public health problem worldwide .',
  'Pesticide drift is a serious environmental and safety concern that affects all of US agriculture .',
  'The indiscriminate use of pesticides has become a serious environmental concern .',
  'The excessive use of pesticides is a serious health problem due to their toxicity and bioaccumulation through the food chain .',
  'Pesticide contamination in the rice fields has manifested into a serious global environmental concern .',
  'Since the beginning of the widespread use of pesticides , their removal from food has become a serious concern .',
  'Comparison of the daily intake peak ( DIP ) and daily intake mean ( DIM ) relative to the acceptable daily intake ( ADI ) shows that groundwater contamination with pesticides is a serious problem .',
  'The contamination levels of pesticide residues and bacterial contaminants could be perceived as a serious problem as most fresh fruits and vegetables recorded values of pesticide residues far above the MRLs with pathogenic bacteria isolated in higher proportions .',
  'Pesticide residues in the food above the maximum permissible residual limit ( MRL ) for safe consumption are a severe concern today .',
  'At present , pesticides used at golf courses have become a severe environmental problem polluting water supplies .',
  'The indiscriminate use of pesticides has been contributing for the environmental quality degradation , as well as it increases the occupational exposures to these products , determining a serious public health problem in rural areas .'],
 'pesticides': ['However , the undesired effects of chemical pesticides have been recognized as a serious public health concern during the past decades .',
  'The largely uncontrolled use of diverse pesticides led us to hypothesize that these agents , and particularly organochlorine compounds , may pose a serious problem in the Republic of Benin .',
  'Deliberate self-poisoning by ingesting pesticides is a serious health problem among farmers , especially in low- and middle-income countries .',
  'These results show that , despite the high levels of some pesticide residues , they may not be considered as a serious public health problem .',
  'However , the pesticide levels found can not be considered a serious health problem according to results from other pesticide monitoring studies .',
  'The results indicate that the occurrence of pesticide residues in apples could not be considered a serious public health problem .',
  'Exposure to insecticides is a serious environmental problem owing to their cytotoxic effects in humans and animals .',
  'Intensive use of pesticides , especially insecticides , in agriculture during the past several decades has already led to contamination of surface and underground waters and sediments in some regions , thus presents a serious problem for the environment .',
  'This results show that the detected pesticides could not be considered a serious public health problem .',
  'Organophosphorus agents ( OPA ) represent a serious concern to public safety as nerve agents and pesticides .',
  'Three of the main classes of pesticides that pose a serious problem are organochlorines , organophosphates and carbamates .',
  'Human poisoning by pesticides has long been seen as a severe public health problem .',
  'Pesticide contamination in Tajikistan is a serious and ongoing problem that requires the attention of local , state governments , and international non-governmental organizations .',
  'Organophosphate/phosphonate ( OPP ) compounds represent a serious concern to public safety as nerve agents and pesticides .',
  'Increase in acute intoxication signs/symptoms and decrease in PChE indicate a serious public health problem among farmers who use organophosphate pesticides .',
  'Acute pesticide poisoning has long been a serious problem as a method of suicide worldwide .',
  'Intentional self-poisoning with pesticides is a serious problem in many developing countries .',
  'Presence of harmful pesticide residue in food is a serious cause for concern among consumers so it is important to monitor levels of pesticides in foods .',
  'The poisoning by psychoactive drugs is increasinging in the recent years and organophosphates poisoning seems to be still a serious problem in such an agricultural area .',
  'Contamination with 1,2-unsaturated pyrrolizidine alkaloids ( PAs ) is a serious problem for certain phytomedicines , foods , and animal feeds .',
  'Global pollution from excessive pesticide use has become a serious environmental and public health problem .',
  'Pesticide poisonings in children continue to be a serious problem .',
  'Haphazard use of pesticides in the field and stored food commodities for the control of insect and pest has been a serious problem from view of environment and public health .',
  'The presence of pesticide residues in fruit is a serious health concern .',
  'Old , obsolete pesticide stocks are a vexing problem in numerous developing countries .',
  'In addition to water contamination , the presence of pesticide residues in food poses a risk to the population , being a serious public health problem in Brazil .',
  'The use of pesticides on cash crops and exportable food commodities had always been a serious concern .',
  'Agricultural pesticides used with the criminal intent to intoxicate domestic and wild animals are a serious concern in Veterinary Medicine .',
  'Pesticide residue in vegetables is a serious problem that has adverse effects on human health .',
  'In recent years , water pollution and pesticide accumulation in the food chain have become a serious environmental and health hazard problem .',
  'Exposure to pesticides has become a serious concern for the environment and human health .',
  'Organophosphate pesticides are used extensively worldwide , and poisoning by these agents , particularly in developing nations , is a serious public health problem .',
  'Exposure to toxic substances , including pesticides , can cause irreversible damage to humans , including death , and is therefore considered a serious public health problem worldwide .',
  'Organophosphorus compounds have been widely employed to the development of warfare nerve agents and pesticides , resulting in a huge number of people intoxicated annually , being a serious problem of public health .',
  'Pesticide and rodenticide poisonings , whether intentional or unintentional , pose a serious threat to populations , and the availability of a banned rodenticide such as tetramethylenedisulfotetramine , with its associated morbidity and lethality , is a serious public health concern .',
  'Although methodological problems constitute a major limitation in interpretation of the results , the literature indicates that parasuicide is a serious public health problem .',
  'Pesticide drift is a serious environmental and safety concern that affects all of US agriculture .',
  'The indiscriminate use of pesticides has become a serious environmental concern .',
  'The inactivation of acetylcholinesterase ( AChE ) by organophosphorus agent ( OP ) compounds is a serious problem regardless of how the individual was exposed .',
  'The excessive use of pesticides is a serious health problem due to their toxicity and bioaccumulation through the food chain .',
  'Pesticide contamination in the rice fields has manifested into a serious global environmental concern .',
  'Exposure to organophosphorus ( OP ) pesticides represents a severe health issue in developing countries , while OP intoxication with the more lethal military nerve agents is not only of military concern but also a terrorist threat .',
  'Since the beginning of the widespread use of pesticides , their removal from food has become a serious concern .',
  'Comparison of the daily intake peak ( DIP ) and daily intake mean ( DIM ) relative to the acceptable daily intake ( ADI ) shows that groundwater contamination with pesticides is a serious problem .',
  'Exposure to toxic organophosphorus pesticides ( OPP ) represents a serious problem in the public healthcare sector and might be forced in terroristic attacks .',
  'The contamination levels of pesticide residues and bacterial contaminants could be perceived as a serious problem as most fresh fruits and vegetables recorded values of pesticide residues far above the MRLs with pathogenic bacteria isolated in higher proportions .',
  'Pesticide residues in the food above the maximum permissible residual limit ( MRL ) for safe consumption are a severe concern today .',
  'Organophosphate ( OP ) intoxication remains a serious worldwide health concern , and many patients with acute OP intoxication have also consumed alcohol .',
  'At present , pesticides used at golf courses have become a severe environmental problem polluting water supplies .',
  'Organophosphorus pesticides have largely been used worldwide , and poisoning by these agents , particularly in developing countries , is a serious health problem .',
  'The indiscriminate use of pesticides has been contributing for the environmental quality degradation , as well as it increases the occupational exposures to these products , determining a serious public health problem in rural areas .'],
 'gambling': ['Problem gambling is a serious global public health concern due to adverse personal and social consequences .',
  'Problem Gambling ( PG ) represents a serious problem for affected individuals , their families and society in general .',
  'A recent meta analysis of studies examining adolescent prevalence rates by Shaffer and Hall ( 1996 ) has suggested that between 77 - 83 % of adolescents are engaging in some form of gambling behavior with between 9.9 % and 14.2 % of youth remaining at risk for a serious gambling problem .',
  'Gambling in children and adolescents is a serious and relatively common problem especially among Czech boys .',
  'Problem gambling emerges as a serious and ever growing problem of modern societies , largely affecting adolescents as well .',
  'Pathological gambling ( PG ) is a severe and persistent pattern of problem gambling that has been aligned with obsessive-compulsive disorder ( OCD ) .',
  'Problem gambling is a serious public health concern at an international level where population prevalence rates average 2 % or more and occurs more frequently in younger populations .',
  'Gambling is a serious concern for society because it is highly addictive and is associated with a myriad of negative outcomes .',
  'A cohort of 2,171 substance abusers were assessed for their gambling behavior , and divided into three groups : those with no significant gambling problem ( 87 % ) ; those with a probable problem ( 7.2 % ) ; and those with a severe problem ( 5.8 % ) .',
  'The findings from this study confirmed that gambling has the potential to become a serious health problem among elders .',
  'Problem gambling ( PG ) is a serious public health concern that disproportionately affects people experiencing poverty , homelessness , and multimorbidity including mental health and substance use concerns .',
  'Early identification and intervention may help prevent a gambling habit escalating to a serious problem .',
  'However , participants who perceived problem gambling as a dangerous condition wanted more social distance than those who did not perceive individuals with a gambling problem as dangerous .',
  'Problem gambling is a serious socioeconomic problem involving high individual and social costs .',
  'The relationship between the convenience , anonymity , and the 24-hour availability of Internet gambling and problem gambling in young people presents a serious concern .',
  'In males , the death of a parent during childhood and physical violence in the past year were positively associated with problem gambling , and a severe parental health problem during childhood was negatively associated with problem gambling .',
  'The aim of this qualitative study was to gain a deeper understanding of the experiences of Australian children who live in families where a parent or caregiver has a serious gambling problem by exploring the perspectives and understandings of the children and young people themselves .',
  'Rather , it is a serious problem in the gambling literature .',
  'Relapse is a serious challenge in problem gambling ( PG ) , as it is in substance addiction .',
  'Problem gambling emerges as a serious and ever growing problem of modern societies , largely affecting adolescents as well .',
  "Adolescents ' use of the Internet and other digital media for the purpose of gambling represents a serious concern in modern society .",
  'Although gambling disorder is a serious social problem in modern societies , information about the behavioral traits that could determine vulnerability to this psychopathology is still scarce .',
  'There is a severe lack of instruments to assess problem gambling in Chinese people .',
  'Pathological ( compulsive ) gambling is a serious emotional and social problem that has existed for centuries but has only recently been recognized as a distinct diagnostic entity that can be effectively treated .'],
 'viral': ['Hepatitis is a serious health concern with a high rate of mortality and morbidity world over .',
  'Viral hepatitis is a serious health problem throughout the world .',
  'The determination of the bioequivalence of HVDs has been a vexing problem since the inception of the current regulations .',
  'Mouse hepatitis virus ( MHV ) infection in laboratory mouse populations is a serious problem , because the MHV infections are known to interfere with research results .',
  'Viral hepatitis B , C and delta still remain a serious problem worldwide .',
  'Viral hepatitis , mainly hepatitis B and C , is a serious public health problem worldwide .',
  'Worldwide , viral hepatitis chronic infections are a serious health problem and a very interesting topic for both clinicians and researchers .',
  '[ Viral hepatitis ... a serious public health problem ] .',
  'The viral hepatitis is a serious public health problem worldwide .',
  'Although viral hepatitis infections are recognized as a serious health problem in the country , not many epidemiological and clinical studies have been done .',
  'Hepatitis is a serious public health problem with increasing cases and property damage in Heng County .',
  'Viral hepatitis is a serious global public health problem .',
  'Hepatitis caused by HEV infection has been a serious public health problem in developing countries .',
  'Viral hepatitis is a serious public health problem .',
  'Viral hepatitis represents a serious public health problem in the world especially in the Maghreb where the prevalence of the 5 viruses A , B , C , D , and E remains high and varies from one Maghreb country to another , there is few published studies on these infections in our Maghreb countries .',
  'Viral hepatitis is a serious health problem that deserves special attention .',
  'Viral hepatitis is a serious public health problem affecting billions of people globally .',
  'We report three cases of fatal INH-associated hepatitis that illustrate that this complication of preventive INH use remains a serious problem .',
  'Viral Hepatitis B , C and D are a serious public health problem in Brazil and other South American countries , mainly in the Amazonian region .',
  'Viral hepatitis is a serious public health problem affecting billions of people globally with maternal-fetal transmission on the rise .',
  'Viral hepatitis is a serious problem worldwide that was under-recognized till recently .',
  'In Pakistan , viral hepatitis is a serious public health problem affecting millions of people .',
  'Viral fulminant hepatitis ( FH ) remains a serious clinical problem with very high mortality .',
  'The presence of HAV in water samples constitutes a serious public health problem .',
  'Viral hepatitis B , C and delta still remain a serious problem in Latin America .',
  'Viral hepatitis is a serious health problem all over the world .',
  'Viral hepatitis is a serious medical and economic problem .',
  'On the last twenty years , viral hepatitis has emerged as a serious problem in almost all the Amerindian communities studied in the Amazon Basin and in other Amazon-related ecological systems from the North and Center of South America .',
  'HDV infection still remains a serious public health problem in Amazonia .',
  'Hepatitis D caused by the hepatitis delta virus ( HDV ) is a serious health problem in many regions of the world .',
  'Hepatitis A virus ( HAV ) still continues to be a serious public health problem worldwide .',
  'Hepatitis delta ( HDV ) virus still poses a serious health problem worldwide .',
  'Fulminant viral hepatitis ( FH ) remains a serious clinical problem for which the underlying pathogenesis remains unclear .',
  'Chronic forms of viral B , C and D hepatitis and fulminant hepatitis represent a serious healthcare problem .',
  'Type A hepatitis virus ( HAV ) is a serious health problem throughout the world and can be spread via fecal-oral contact .',
  'Hepatitis delta virus ( HDV ) infection is a serious health problem worldwide .',
  'Hepatitis A virus ( HAV ) infection is one of the most common causes of acute hepatitis and it is a serious health problem worldwide .',
  'Infectious hepatitis is a serious problem affecting millions of people worldwide , particularly in China and other developing countries , and it is the major risk factor for hepatic cirrhosis .',
  'Viral hepatitis is a serious health problem all over the world .',
  'Chronic hepatitis in children represents a serious health and social problem .'],
 'elder': ['The physical abuse , psychological abuse , exploitation , and neglect of older adults constitute a serious and under-recognized public health problem throughout the world .',
  'Elder abuse is a serious public health concern that increases the risks of negative health outcomes globally .',
  'Self-neglect is a serious and burgeoning public health challenge representing the most common problem faced by Adult Protective Services agencies .',
  'The financial exploitation of older adults was recently recognized by the Centers for Disease Control and Prevention as a serious public health problem .',
  'Elder abuse is a serious problem that has adverse consequence on health . Still , research on elder abuse is sparse in India .',
  'Researchers and clinicians concur that elder abuse is underreported , is a serious problem , rarely occurs as an isolated event , persists over extended periods , and requires coordinated intervention .',
  "Elder abuse is a serious problem affecting an older person 's health and well-being .",
  'Elder abuse is a serious national problem with potential for significant physical , emotional , and financial harm .',
  'Elder abuse is recognised worldwide as a serious problem , yet quantitative syntheses of prevalence studies are rare .',
  'Abuse of older people is a serious and growing social problem .',
  'Nowadays , elder abuse is a serious problem in many countries .',
  'Elder abuse is now being recognised as a serious social problem .',
  'Elder abuse is a preventable problem .',
  'Most of the participants regarded abuse and neglect of the older people as a serious problem and considered it their responsibility to intervene when they encountered it .',
  'Self-neglect is a serious and growing problem among older adults .',
  'Elder abuse is an under-researched area despite being globally recognized as a serious and escalating problem .',
  'One of these is elder abuse and neglect , a serious and growing problem .'],
 'abuse': ['The physical abuse , psychological abuse , exploitation , and neglect of older adults constitute a serious and under-recognized public health problem throughout the world .',
  'Child sexual abuse is a serious , pervasive problem with clinical , social , moral , and legal implications .',
  'Elder abuse is a serious public health concern that increases the risks of negative health outcomes globally .',
  'Child and adolescent sexual abuse is considered to be a serious public health concern and a devastating form of violence with serious physical , mental , and behavioral consequences in the short and long term .',
  'Child sexual abuse ( CSA ) is a preventable public health problem typically addressed with either after-the-fact interventions or prevention programs focused on teaching children to protect themselves and report abuse .',
  'Self-neglect is a serious and burgeoning public health challenge representing the most common problem faced by Adult Protective Services agencies .',
  'Sexual abuse can lead to long-lasting , even life-long , consequences and is a serious problem on an individual , familial and societal level .',
  'The financial exploitation of older adults was recently recognized by the Centers for Disease Control and Prevention as a serious public health problem .',
  'Child sexual abuse ( CSA ) is a serious problem causing physical , social and psychosocial harm .',
  'Despite controversy about the impact of sexual abuse on victims , accumulating evidence indicates that sexual abuse is a serious mental health problem .',
  'Sexual abuse of deaf youth is a serious problem that needs to have attention given to it in a way that will lead to real changes in the lives of the boys and girls affected .',
  'Elder abuse is a serious problem that has adverse consequence on health . Still , research on elder abuse is sparse in India .',
  'Intrafamilial child sexual abuse is a serious social and health problem , yet explanations of sexual offending against children that emphasize antisocial tendencies and atypical sexual interests do not adequately explain intrafamilial offending .',
  'Researchers and clinicians concur that elder abuse is underreported , is a serious problem , rarely occurs as an isolated event , persists over extended periods , and requires coordinated intervention .',
  'Childhood sexual abuse is a severe problem worldwide .',
  "Elder abuse is a serious problem affecting an older person 's health and well-being .",
  'Child sexual abuse ( CSA ) is a serious problem not only in the community but also in institutional settings such as youth-serving organizations , churches , and schools .',
  'International sex trafficking into the United States appears to be a serious and growing problem , although the evidence regarding prevalence , risk , and consequences is incomplete .',
  'Elder abuse is a serious national problem with potential for significant physical , emotional , and financial harm .',
  'The proposed approach is empirically tested using real data from a national survey of inmate sexual abuse where measurement errors are a serious concern .',
  'Elder abuse is recognised worldwide as a serious problem , yet quantitative syntheses of prevalence studies are rare .',
  'Abuse of older people is a serious and growing social problem .',
  'Recent literature pertinent to adult survivors suggests that childhood sexual abuse is a serious problem , and that disclosure is on the rise .',
  'Despite widespread recognition of child sexual abuse as a serious problem in sub-Saharan Africa , few far-reaching programmatic interventions addressing child sexual abuse in this setting are currently available , and those interventions that do exist tend to focus on response rather than prevention .',
  'Nowadays , elder abuse is a serious problem in many countries .',
  'Since child sexual abuse may endanger the life and well-being of the child , it is a serious problem that requires urgent action .',
  'The under-reporting of child sexual abuse by victims is a serious problem that may prolong the suffering of victims and leave perpetrators free to continue offending .',
  'Commercial sexual exploitation of children ( CSEC ) and adolescents is a serious worldwide problem .',
  'Elder abuse is now being recognised as a serious social problem .',
  'Childhood sexual abuse ( CSA ) is a serious public health problem worldwide .',
  'Elder abuse is a preventable problem .',
  'The experience of sexual abuse in childhood is a serious public health problem that is associated with suicidal behavior in numerous cases .',
  'Changing the paradigm : Using strategic communications to promote recognition of child sexual abuse as a preventable public health problem .',
  'Adolescents who have sexually abused may pose a serious problem for both the community and the treatment provider concerning the management of risk and the application of effective intervention strategies .',
  'Although sexual abuse of children is recognized as a serious problem , sibling incest has received relatively little attention .',
  'Most of the participants regarded abuse and neglect of the older people as a serious problem and considered it their responsibility to intervene when they encountered it .',
  'Incest , is a serious social problem facing society and children/adolescents themselves .',
  'Childhood sexual abuse is a serious problem .',
  'Sexual victimization by adolescents is a serious problem of growing societal concern .',
  'Self-neglect is a serious and growing problem among older adults .',
  'Commercial sexual exploitation and sex trafficking of children and adolescents represent a severe form of child abuse and an important pediatric health concern .',
  'Elder abuse is an under-researched area despite being globally recognized as a serious and escalating problem .',
  'One of these is elder abuse and neglect , a serious and growing problem .',
  'Child sexual abuse ( CSA ) is a serious public health problem that increases risk for physical and mental health problems across the life course .'],
 'neglect': ['The physical abuse , psychological abuse , exploitation , and neglect of older adults constitute a serious and under-recognized public health problem throughout the world .',
  'Elder abuse is a serious public health concern that increases the risks of negative health outcomes globally .',
  'Self-neglect is a serious and burgeoning public health challenge representing the most common problem faced by Adult Protective Services agencies .',
  'The financial exploitation of older adults was recently recognized by the Centers for Disease Control and Prevention as a serious public health problem .',
  'Elder abuse is a serious problem that has adverse consequence on health . Still , research on elder abuse is sparse in India .',
  'Researchers and clinicians concur that elder abuse is underreported , is a serious problem , rarely occurs as an isolated event , persists over extended periods , and requires coordinated intervention .',
  "Elder abuse is a serious problem affecting an older person 's health and well-being .",
  'Elder abuse is a serious national problem with potential for significant physical , emotional , and financial harm .',
  'Elder abuse is recognised worldwide as a serious problem , yet quantitative syntheses of prevalence studies are rare .',
  'Abuse of older people is a serious and growing social problem .',
  'Nowadays , elder abuse is a serious problem in many countries .',
  'Elder abuse is now being recognised as a serious social problem .',
  'Elder abuse is a preventable problem .',
  'Most of the participants regarded abuse and neglect of the older people as a serious problem and considered it their responsibility to intervene when they encountered it .',
  'Self-neglect is a serious and growing problem among older adults .',
  'Elder abuse is an under-researched area despite being globally recognized as a serious and escalating problem .',
  'One of these is elder abuse and neglect , a serious and growing problem .'],
 'older': ['The physical abuse , psychological abuse , exploitation , and neglect of older adults constitute a serious and under-recognized public health problem throughout the world .',
  'Depression is a serious mental health issue and a major concern among middle-aged women , especially during the menopause transition time .',
  'Undertreatment of depressive symptoms among older persons remains a serious problem .',
  'Elder abuse is a serious public health concern that increases the risks of negative health outcomes globally .',
  'Depression in older adults is a serious health problem with a poor prognosis .',
  'Self-neglect is a serious and burgeoning public health challenge representing the most common problem faced by Adult Protective Services agencies .',
  'The financial exploitation of older adults was recently recognized by the Centers for Disease Control and Prevention as a serious public health problem .',
  'Depression is a serious problem for the oldest-old but a number of correlates are consistently identified in the oldest-old , as well as the two other age groups in the elderly population .',
  'Late-life depression ( LLD ) is a severe public health problem .',
  'The implications of failure to recognize the possibility of depression among elderly White men suggest a serious public health problem .',
  'Elder abuse is a serious problem that has adverse consequence on health . Still , research on elder abuse is sparse in India .',
  'Researchers and clinicians concur that elder abuse is underreported , is a serious problem , rarely occurs as an isolated event , persists over extended periods , and requires coordinated intervention .',
  "Elder abuse is a serious problem affecting an older person 's health and well-being .",
  'Depression is a serious mental health problem in older adults .',
  'Late-life depression is a serious health problem that is challenging to manage but generally responds well to pharmacotherapy .',
  'Depression is a serious problem for many older adults but is too often undetected by the person , family or providers .',
  'Elder abuse is a serious national problem with potential for significant physical , emotional , and financial harm .',
  'Elder abuse is recognised worldwide as a serious problem , yet quantitative syntheses of prevalence studies are rare .',
  'Abuse of older people is a serious and growing social problem .',
  'The diagnosis and treatment of depression in elderly adults is a serious concern in outpatient settings , where it is well known that practicing physicians often overlook the possibility of depression in adult patients of all ages .',
  'Nowadays , elder abuse is a serious problem in many countries .',
  'Depressive disorders in people older than 65 years seem to be a serious medical and social problem in many countries .',
  'Depression among elderly primary care patients is a serious problem with significant morbidity and mortality .',
  'Depression is a serious public health problem that particularly affects women and elderly people .',
  'Elder abuse is now being recognised as a serious social problem .',
  'However , because undertreatment remains a serious problem among depressed elderly , well-designed prescription drug policies should be coupled with interventions to address under-treatment .',
  'Elder abuse is a preventable problem .',
  'Most of the participants regarded abuse and neglect of the older people as a serious problem and considered it their responsibility to intervene when they encountered it .',
  'Thus , depression in late life is a serious mental health problem .',
  'Self-neglect is a serious and growing problem among older adults .',
  'With the older population increasing worldwide , depressive disorder in this cohort is a serious public health problem that contributes to increased healthcare costs and mortality .',
  'Depression in later life is a severe public health problem , associated with higher rates of mortality , suicide , and dementia .',
  'Late-life depression is a serious public health problem and a concern for the primary care physician .',
  'Depression among caregivers of older persons is a serious concern , but it is often overlooked and neglected in developing countries .',
  'Diagnosing depression in the elderly poses a serious problem because of the ageing process and various diseases that influence and mask symptoms of depressed mood .',
  'Elder abuse is an under-researched area despite being globally recognized as a serious and escalating problem .',
  'One of these is elder abuse and neglect , a serious and growing problem .',
  'Older adults with low incomes rarely use mental health care , and untreated depression is a serious problem in this population .'],
 'exploitation': ['The physical abuse , psychological abuse , exploitation , and neglect of older adults constitute a serious and under-recognized public health problem throughout the world .',
  'Elder abuse is a serious public health concern that increases the risks of negative health outcomes globally .',
  'Self-neglect is a serious and burgeoning public health challenge representing the most common problem faced by Adult Protective Services agencies .',
  'The financial exploitation of older adults was recently recognized by the Centers for Disease Control and Prevention as a serious public health problem .',
  'Elder abuse is a serious problem that has adverse consequence on health . Still , research on elder abuse is sparse in India .',
  'Researchers and clinicians concur that elder abuse is underreported , is a serious problem , rarely occurs as an isolated event , persists over extended periods , and requires coordinated intervention .',
  "Elder abuse is a serious problem affecting an older person 's health and well-being .",
  'Elder abuse is a serious national problem with potential for significant physical , emotional , and financial harm .',
  'Elder abuse is recognised worldwide as a serious problem , yet quantitative syntheses of prevalence studies are rare .',
  'Abuse of older people is a serious and growing social problem .',
  'Nowadays , elder abuse is a serious problem in many countries .',
  'Elder abuse is now being recognised as a serious social problem .',
  'Elder abuse is a preventable problem .',
  'Most of the participants regarded abuse and neglect of the older people as a serious problem and considered it their responsibility to intervene when they encountered it .',
  'Self-neglect is a serious and growing problem among older adults .',
  'Elder abuse is an under-researched area despite being globally recognized as a serious and escalating problem .',
  'One of these is elder abuse and neglect , a serious and growing problem .'],
 'trypanosoma': ['Chagas disease ( CD ) , a neglected tropical disease caused by Trypanosoma cruzi , remains a serious public health problem in several Latin American countries .',
  'Chagas disease , caused by the protozoan Trypanosoma cruzi , remains a serious health concern due to the lack of effective vaccines or satisfactory treatment .',
  'Chagas disease is a serious public health problem in Latin America where about ten million individuals show Trypanosoma cruzi infection .',
  "Chagas ' disease is a neglected tropical disease caused by Trypanosoma cruzi and constitutes a serious public health problem for Latin America .",
  'Human African trypanosomiasis ( HAT ) , commonly known as sleeping sickness has remained a serious health problem in many African countries with thousands of new infected cases annually .',
  'Chagas disease is a serious problem of parasitic disease in the American continent , this zoonosis is caused by the flagellated protozoan known as Trypanosoma cruzi and transmitted through trypomastigotes present in the blood of sick hosts or in the faeces of the triatomines .',
  'Emerging reports of drug resistance in Trypanosoma brucei are a serious cause of concern as only limited drugs are available for the treatment of the disease .',
  "Trypanosoma cruzi is the causative agent of Chagas ' disease , a parasitic disease that remains a serious health concern with unsatisfactory treatment .",
  "Chagas ' disease , caused by the protozoan Trypanosoma cruzi , represents a serious health problem in Latin America , and the available chemotherapy , which is based on 2 nitro-derivatives , is not satisfactory .",
  'The parasite Trypanosoma cruzi causes Chagas disease , which remains a serious public health concern and continues to victimize thousands of people , primarily in the poorest regions of Latin America .',
  'Chagas disease , which is caused by the intracellular protozoan Trypanosoma cruzi , is a serious health problem in Latin America .',
  'Africa Trypanosomiasis remains a serious health problem , but the approved drugs for this disease are so few that novel trypanocidal compounds are demanded .',
  'Drug resistance is now a severe and increasing problem in trypanosomes , but molecular details of mechanisms of resistance are only beginning to unveil .',
  'Human African trypanosomiasis , caused by the eukaryotic parasite Trypanosoma brucei , is a serious health problem in much of central Africa .',
  'Chagas disease ( CD ) , caused by Trypanosoma cruzi , remains a serious public health problem .',
  "American trypanosoniasis or Chagas ' Disease is a serious health problem in Latin America .",
  'Chagas disease is a serious public health problem in Ecuador , where nearly 230,000 individuals show Trypanosoma cruzi infection .',
  'Chagas disease , caused by Trypanosoma cruzi , remains a serious public health concern in many areas of Latin America , including México .',
  'Trypanosoma brucei is the etiological agent responsible for African trypanosomiasis , an infectious pathology which represents a serious problem of public health and economic losses in Sub-Saharan Africa .',
  'Resistance to diminazene aceturate ( Berenil ) is a severe problem in the control of African trypanosomiasis in domestic animals .',
  'Sleeping sickness caused by Trypanosoma brucei ( T.b . ) gambiense constitutes a serious health problem in sub-Sahara Africa .',
  'Trypanosoma cruzi transplacental infection represents a serious public health concern in all the countries like Chile where recent success of insecticide spraying programs eliminated the vector .',
  'Chagas disease , caused by the protozoan Trypanosoma cruzi , remains a serious public health problem in Latin America .',
  'American trypanosomiasis or Chagas disease ( CD ) is a vector borne pathology caused by the parasite Trypanosoma cruzi ( T. cruzi ) , which remains a serious global health problem .',
  'Human African trypanosomiasis ( HAT ) remains a serious public health problem with diagnostic and treatment challenges in many African countries .',
  'Animal African Trypanosomosis ( AAT ) presents a severe problem for agricultural development in sub-Saharan Africa .',
  'American trypanosomiasis or Chagas disease is a debilitating disease representing an important social problem that affects , approximately , 10 million people in the world .',
  'A century after its discovery , American trypanosomiasis or Chagas disease remains a serious health problem in Latin America , where it affects around 7 - 8 million people .',
  'Although Trypanosoma rangeli is harmless for humans , it is a serious problem since it may be confused with diagnosis of Trypanosoma cruzi , the etiologic agent of Chagas disease .',
  'Trypanosoma cruzi associated myocardiopathy , or Chagas disease , continues to be a serious problem in Venezuela , for which there is neither a vaccine nor a cure .',
  'Chagas disease , also known as American trypanosomiasis , is a chronic and systemic parasitic infection which has become a serious epidemiological problem not only in endemic regions ( Latin America ) , but also in non-endemic ones like North America , Europe , and Oceania .',
  'Chagas disease , caused by the parasite Trypanosoma cruzi , represents a serious blood safety problem due to increasing immigration from Latin America .',
  'Chagas disease , caused by the parasite Trypanosoma cruzi , is a serious health problem in Latin America and is an emerging disease in non-endemic countries .',
  'Trypanosoma cruzi , responsible for Chagas disease , is a serious public health problem in Latin America with eight million people infected in the world .',
  'Chagas disease , caused by the intracellular protozoan Trypanosoma cruzi , is a serious health problem in Latin America .',
  'Resistance to currently used drugs is a serious problem in most fields of anti-microbial chemotherapy , particularly in the case of trypanosomosis where resistance and cross-resistance in animals and man have been developing rapidly .',
  'Chagas disease ( CD ) caused by Trypanosoma cruzi remains a serious public health problem in Latin America .',
  "Chagas ' disease is a neglected disease caused by the protozoan parasite Trypanosoma cruzi and constitutes a serious health problem worldwide .",
  'In the Gran Chaco region of Argentina , Bolivia , and Paraguay , vector transmission of Trypanosoma cruzi , the etiological agent of Chagas disease , is still a severe problem because , among other causes , houses are reinfested with Triatoma infestans , the main vector of T. cruzi in southern South America .'],
 'trypanosomiasis': ['Chagas disease ( CD ) , a neglected tropical disease caused by Trypanosoma cruzi , remains a serious public health problem in several Latin American countries .',
  'Chagas disease , caused by the protozoan Trypanosoma cruzi , remains a serious health concern due to the lack of effective vaccines or satisfactory treatment .',
  'Chagas disease is a serious public health problem in Latin America where about ten million individuals show Trypanosoma cruzi infection .',
  "Chagas ' disease is a neglected tropical disease caused by Trypanosoma cruzi and constitutes a serious public health problem for Latin America .",
  'Human African trypanosomiasis ( HAT ) , commonly known as sleeping sickness has remained a serious health problem in many African countries with thousands of new infected cases annually .',
  'Chagas disease is a serious problem of parasitic disease in the American continent , this zoonosis is caused by the flagellated protozoan known as Trypanosoma cruzi and transmitted through trypomastigotes present in the blood of sick hosts or in the faeces of the triatomines .',
  'Emerging reports of drug resistance in Trypanosoma brucei are a serious cause of concern as only limited drugs are available for the treatment of the disease .',
  "Trypanosoma cruzi is the causative agent of Chagas ' disease , a parasitic disease that remains a serious health concern with unsatisfactory treatment .",
  "Chagas ' disease , caused by the protozoan Trypanosoma cruzi , represents a serious health problem in Latin America , and the available chemotherapy , which is based on 2 nitro-derivatives , is not satisfactory .",
  'The parasite Trypanosoma cruzi causes Chagas disease , which remains a serious public health concern and continues to victimize thousands of people , primarily in the poorest regions of Latin America .',
  'Chagas disease , which is caused by the intracellular protozoan Trypanosoma cruzi , is a serious health problem in Latin America .',
  'Africa Trypanosomiasis remains a serious health problem , but the approved drugs for this disease are so few that novel trypanocidal compounds are demanded .',
  'Drug resistance is now a severe and increasing problem in trypanosomes , but molecular details of mechanisms of resistance are only beginning to unveil .',
  'Human African trypanosomiasis , caused by the eukaryotic parasite Trypanosoma brucei , is a serious health problem in much of central Africa .',
  'Chagas disease ( CD ) , caused by Trypanosoma cruzi , remains a serious public health problem .',
  "American trypanosoniasis or Chagas ' Disease is a serious health problem in Latin America .",
  'Chagas disease is a serious public health problem in Ecuador , where nearly 230,000 individuals show Trypanosoma cruzi infection .',
  'Chagas disease , caused by Trypanosoma cruzi , remains a serious public health concern in many areas of Latin America , including México .',
  'Trypanosoma brucei is the etiological agent responsible for African trypanosomiasis , an infectious pathology which represents a serious problem of public health and economic losses in Sub-Saharan Africa .',
  'Resistance to diminazene aceturate ( Berenil ) is a severe problem in the control of African trypanosomiasis in domestic animals .',
  'Sleeping sickness caused by Trypanosoma brucei ( T.b . ) gambiense constitutes a serious health problem in sub-Sahara Africa .',
  'Trypanosoma cruzi transplacental infection represents a serious public health concern in all the countries like Chile where recent success of insecticide spraying programs eliminated the vector .',
  'Chagas disease , caused by the protozoan Trypanosoma cruzi , remains a serious public health problem in Latin America .',
  'American trypanosomiasis or Chagas disease ( CD ) is a vector borne pathology caused by the parasite Trypanosoma cruzi ( T. cruzi ) , which remains a serious global health problem .',
  'Human African trypanosomiasis ( HAT ) remains a serious public health problem with diagnostic and treatment challenges in many African countries .',
  'Animal African Trypanosomosis ( AAT ) presents a severe problem for agricultural development in sub-Saharan Africa .',
  'American trypanosomiasis or Chagas disease is a debilitating disease representing an important social problem that affects , approximately , 10 million people in the world .',
  'A century after its discovery , American trypanosomiasis or Chagas disease remains a serious health problem in Latin America , where it affects around 7 - 8 million people .',
  'Although Trypanosoma rangeli is harmless for humans , it is a serious problem since it may be confused with diagnosis of Trypanosoma cruzi , the etiologic agent of Chagas disease .',
  'Trypanosoma cruzi associated myocardiopathy , or Chagas disease , continues to be a serious problem in Venezuela , for which there is neither a vaccine nor a cure .',
  'Chagas disease , also known as American trypanosomiasis , is a chronic and systemic parasitic infection which has become a serious epidemiological problem not only in endemic regions ( Latin America ) , but also in non-endemic ones like North America , Europe , and Oceania .',
  'Chagas disease , caused by the parasite Trypanosoma cruzi , represents a serious blood safety problem due to increasing immigration from Latin America .',
  'Chagas disease , caused by the parasite Trypanosoma cruzi , is a serious health problem in Latin America and is an emerging disease in non-endemic countries .',
  'Trypanosoma cruzi , responsible for Chagas disease , is a serious public health problem in Latin America with eight million people infected in the world .',
  'Chagas disease , caused by the intracellular protozoan Trypanosoma cruzi , is a serious health problem in Latin America .',
  'Resistance to currently used drugs is a serious problem in most fields of anti-microbial chemotherapy , particularly in the case of trypanosomosis where resistance and cross-resistance in animals and man have been developing rapidly .',
  'Chagas disease ( CD ) caused by Trypanosoma cruzi remains a serious public health problem in Latin America .',
  "Chagas ' disease is a neglected disease caused by the protozoan parasite Trypanosoma cruzi and constitutes a serious health problem worldwide .",
  'In the Gran Chaco region of Argentina , Bolivia , and Paraguay , vector transmission of Trypanosoma cruzi , the etiological agent of Chagas disease , is still a severe problem because , among other causes , houses are reinfested with Triatoma infestans , the main vector of T. cruzi in southern South America .'],
 'cyberbullying': ['E-mail systems and online social media platforms are ideal places for news dissemination , but a serious problem is the spread of fraudulent news headlines .',
  'The cyberbullying phenomenon is clearly established in our society and a small percentage of cases it becomes a serious problem .',
  'Computer mediation of communication potentially diffuses responsibility ; imposes a temporal asynchrony between signified intent and audience response ; and reduces the empathy that might motivate observers or witnesses to intervene and render assistance , factors that make online baiting a serious social , legal and technological problem .',
  'With the development of Internet technology , cyberbullying has become a serious social issue and public concern in modern society .',
  'Hate speech has long posed a serious problem for the integrity of digital platforms .',
  'Cyberbullying is associated with considerable negative mental and psychosocial consequences in children and young people , making it a serious public health concern .',
  "Sexual cyberbullying is becoming a serious problem in today 's society .",
  'Cyberbullying victimization and perpetration continues to be a serious public health , criminal justice , victimology , and educational problem in middle schools in the United States .',
  'In recent years , cyberbullying has been recognized as a severe public health problem and is drawing growing interest .',
  'With the emergence of fake news at a very rapid rate , a serious concern has produced in our society because of enormous fake content dissemination .',
  'Despite being relatively new , cyberbullying is now well recognized as a serious public health problem affecting children and adolescents .',
  'The widespread use of social networks has turned cyber violence into a serious problem .'],
 'acute': ['Acute kidney injury ( AKI ) is a serious problem in critically ill patients of intensive care units .',
  'Acute kidney injury ( AKI ) remains a serious clinical problem in the intensive care unit ( ICU ) .',
  'DIN accounts for 18 - 27 % of community- and hospital-acquired episodes of acute kidney injury ( AKI ) and is a serious concern during development of novel therapeutic drugs .',
  'Acute kidney injury is a serious global health problem and determinant of morbidity and mortality .',
  'Acute kidney injury ( AKI ) is a serious clinical problem with high morbidity and mortality .',
  'Ischemic acute kidney injury ( AKI ) is a serious clinical problem and no efficient therapeutics is available in clinic now .',
  'Acute kidney injury ( AKI ) is a serious clinical problem with high rate of mortality and morbidity .',
  'Acute kidney injury ( AKI ) is a severe and preventable problem of crushed earthquake victims .',
  'Acute kidney injury is a serious public health problem , especially in intensive care units , where patients may require dialysis support , resulting in 50 % mortality .',
  'Renal involvement can be a serious problem for patients with antiphospholipid syndrome ( APS ) .',
  'Acute kidney injury following cardiac surgery depicts a severe clinical problem that is strongly associated with adverse short- and long-term outcome .',
  'Acute kidney injury ( AKI ) is a serious global public health problem .',
  'The occurrence of non-function in one half of a horseshoe kidney resulting from hydronephrosis can , if unrecognized , create a serious surgical as well as medical problem .',
  'Acute kidney injury ( AKI ) is a serious and common problem that is associated with high mortality .',
  'Acute renal failure ( ARF ) remains a serious medical problem with a high mortality rate .',
  'Acute kidney injury ( AKI ) constitutes a serious public health problem because of its very high cost and mortality rate , with an increasing incidence , phenomenon which is explained by the increasingly number of older patients suffering from several comorbidities admitted in the intensive care units .',
  'Renal failure after bypass is still a threatening problem prolonging hospital care and reducing overall survival .',
  'In fact , drug-induced kidney injury is a serious problem in clinical practice and accounts for roughly 20 % of cases of acute kidney injury ( AKI ) among hospitalized patients .',
  'Acute kidney injury ( AKI ) is a serious problem .',
  'Acute kidney injury ( AKI ) is a devastating clinical problem that affects a growing number of patients , especially elderly ones , and is associated with high morbidity and mortality .',
  'In critically ill patients , acute kidney injury ( AKI ) is a devastating problem often associated with adverse outcomes .',
  'Acute Renal Failure ( ARF ) is the most costly kidney disease in hospitalized patients and remains as a serious problem in clinical medicine .',
  'Acute kidney injury following cardiac surgery is a serious problem among patients in eastern Saudi Arabia .',
  'Acute renal failure presents a serious and life-threatening problem in hospitalized patients .',
  'Acute kidney injury remains a serious clinical problem for intensive care unit patients , and its incidence is rising .',
  'Acute kidney injury ( AKI ) remains a vexing clinical problem that results in unacceptably high patient mortality , development of chronic kidney disease , and accelerated progression to end-stage kidney disease .',
  'Acute kidney injury ( AKI ) can be a devastating problem for hospitalized patients .',
  'Acute kidney injury in the context of nephrotic syndrome is a serious and alarming clinical problem .',
  'Acute kidney injury ( AKI ) is a serious problem occurring in anywhere between 8 and 30 % of children in the intensive care unit .'],
 'echinococcosis': ['Human echinococcosis remains a serious health problem for the Mediterranean countries .',
  'Hydatidosis/echinococcosis ( Echinococcus granulosus infection ) is considered to be a serious problem for both public health and the livestock economy in Greece .',
  'Echinococcal disease is still a serious problem in certain parts of the world .',
  'Cystic echinococcosis , which is one of the most important helminthic infestations , is a serious life-threatening health problem in developing countries .',
  'Cystic echinococcosis due to Echinococcus granulosus is a serious public health and economic concern in India .',
  'Cystic echinococcosis due to Echinococcus granulosus is a serious public health and livestock economy problem in Libya .',
  'Human cystic echinococcosis ( CE ) is a serious public health problem in West China .',
  'Cystic echinococcosis ( CE ) , caused by Echinococcus granulosus metacestode , invokes a serious public health concern .',
  'Cystic echinococcosis due to E. granulosus is a serious public health and livestock economy problem in Libya .',
  'Currently , cystic echinococcosis ( CE ) follow-up is a serious concern among surgeons .',
  'Cardiac and pericardial echinococcosis as a life-threatening disease may present with a clear picture most of the time , however it may also become a clinical puzzle .',
  'Human cystic echinococcosis ( CE ) caused by infection with a larval stage of Echinococcus granulosus is a serious public health problem in West China .',
  'Hydatidosis ( cystic echinococcosis ) constitutes a serious public health problem in the Province of Rio Negro , Argentina .',
  'Echinococcosis continues to be a severe public health problem in this part of China because of unhygienic practices/habits and poor knowledge among the communities regarding this disease .',
  'Cystic echinococcosis ( CE ) caused by Echinococcus granulosus remains a serious problem worldwide for issues relating to public health and the economy .',
  'Alveolar echinococcus ( AE ) is a severe health problem in endemic areas .',
  'Given that cystic echinococcosis ( CE ) is a serious clinical problem in endemic countries , there is still relatively little information available on the natural history of the human disease .',
  'Liver echinococcosis is an endemic disease in some areas of the world like Middle East and is a serious problem both from social-economic and clinical-therapeutical stand-points in other areas like Mediterranean regions .',
  'Hydatid disease caused by echinococcus granulosus is still a serious problem in both underdeveloped and developing countries .',
  'Human alveolar echinococcosis ( HAE ) , caused by the larvae of Echinococcus multilocularis , is a severe parasitic disease that is a major public health concern .',
  'Human cystic echinococcosis ( CE ) caused by infection with a larval stage of Echinococcus granulosus is a serious public health problem in Turkey .',
  'Cystic echinococcosis is a zoonotic disease with a wide geographical distribution , Greece included , and is considered to be a serious problem for the public health and the livestock economy .',
  'Human echinococcoses are parasitic helminth infections that constitute a serious public health concern in several regions across the world .',
  'Cystic echinococcosis ( CE ) is a serious public health problem in sheep-raising regions of Turkey .',
  'The cystic echinococcosis described as a young adult disease may actually observed at any age and remains a serious problem of public health in Tunisia .',
  'Childhood echinococcosis remains a serious health problem for the country .',
  'Hydatid disease caused by echinococcus granulosus is still a serious problem in both underdeveloped and developing countries .',
  'In the endemic countries , human cystic echinococcosis ( CE ) poses a serious medical and social problem .',
  'The cestode Echinococcus multilocularis infection , a serious health problem worldwide , causes alveolar echinococcosis ( AE ) , a tumor-like disease predominantly located in the liver and able to spread to any organs .',
  'Cystic echinococcosis is a serious public health problem in developing countries .',
  'Echinococcosis is still a serious problem particularly in endemic areas such as South and Central America , Mediterranean countries , and Russia .',
  'Management options for cystic echinococcosis ( CE ) remain a serious problem .',
  'Human echinococcosis remains a serious health problem for the Mediterranean countries , among them Greece .',
  'In Algeria , cystic echinococcosis ( CE ) is a serious economic and public health problem .',
  'Cystic echinococcosis , which commonly starts during childhood or adolescence , is a serious problem of public health in Tunisia .'],
 'cystic': ['Human echinococcosis remains a serious health problem for the Mediterranean countries .',
  'Hydatidosis/echinococcosis ( Echinococcus granulosus infection ) is considered to be a serious problem for both public health and the livestock economy in Greece .',
  'Notorious for its antibiotic multiresistance , P. aeruginosa is increasingly recognized as a serious problem in hospitalized patients .',
  'Multi-drug resistance among Pseudomonas aeruginosa ( P. aeruginosa ) clinical isolates is increasing and becoming a serious problem for public health authorities worldwide .',
  'Echinococcal disease is still a serious problem in certain parts of the world .',
  'Cystic echinococcosis , which is one of the most important helminthic infestations , is a serious life-threatening health problem in developing countries .',
  'Pseudomonas aeruginosa is an increasingly prevalent pathogen that has become a serious health concern due to an increasing incidence of multidrug-resistant ( MDR ) hospital-acquired infections .',
  'Infections with Pseudomonas aeruginosa are a severe problem for hospitalized patients and for patients suffering from cystic fibrosis .',
  'Cystic echinococcosis due to Echinococcus granulosus is a serious public health and economic concern in India .',
  'Cystic echinococcosis due to Echinococcus granulosus is a serious public health and livestock economy problem in Libya .',
  'As colonizers of medical-device surfaces , Pseudomonas aeruginosa strains present a serious source of infection and are of major concern .',
  'Human cystic echinococcosis ( CE ) is a serious public health problem in West China .',
  'Cystic echinococcosis ( CE ) , caused by Echinococcus granulosus metacestode , invokes a serious public health concern .',
  'In many centers , Pseudomonas cepacia has emerged as a serious problem in patients with cystic fibrosis .',
  'Cystic echinococcosis due to E. granulosus is a serious public health and livestock economy problem in Libya .',
  'Currently , cystic echinococcosis ( CE ) follow-up is a serious concern among surgeons .',
  'Infection caused by drug-resistant P. aeruginosa is important to identify as it poses a therapeutic problem and is also a serious concern for infection control management .',
  'Cardiac and pericardial echinococcosis as a life-threatening disease may present with a clear picture most of the time , however it may also become a clinical puzzle .',
  'Increase of multiple drug resistant Pseudomonas aeruginosa ( MDRP ) is becoming a serious problem in the clinical setting .',
  'Chronic pulmonary infections with Pseudomonas aeruginosa remain a serious problem in patients with cystic fibrosis .',
  'The emergence of multidrug-resistant Pseudomonas aeruginosa has become a serious problem in medical settings .',
  'Human cystic echinococcosis ( CE ) caused by infection with a larval stage of Echinococcus granulosus is a serious public health problem in West China .',
  'The infection caused by Pseudomonas aeruginosa is a serious concern in human health .',
  'Hydatidosis ( cystic echinococcosis ) constitutes a serious public health problem in the Province of Rio Negro , Argentina .',
  'Echinococcosis continues to be a severe public health problem in this part of China because of unhygienic practices/habits and poor knowledge among the communities regarding this disease .',
  'Cystic echinococcosis ( CE ) caused by Echinococcus granulosus remains a serious problem worldwide for issues relating to public health and the economy .',
  'Alveolar echinococcus ( AE ) is a severe health problem in endemic areas .',
  'Given that cystic echinococcosis ( CE ) is a serious clinical problem in endemic countries , there is still relatively little information available on the natural history of the human disease .',
  'Liver echinococcosis is an endemic disease in some areas of the world like Middle East and is a serious problem both from social-economic and clinical-therapeutical stand-points in other areas like Mediterranean regions .',
  'Pseudomonas aeruginosa is an opportunistic bacterial pathogen that forms a serious problem for immunocompromised patients and also the leading cause of mortality in cystic fibrosis .',
  'Hydatid disease caused by echinococcus granulosus is still a serious problem in both underdeveloped and developing countries .',
  'Pseudomonas aeruginosa ( P. aeruginosa ) is a menacing opportunistic , nosocomial pathogen ; become a growing concern as conventional antimicrobial therapy is now futile against it .',
  'Human alveolar echinococcosis ( HAE ) , caused by the larvae of Echinococcus multilocularis , is a severe parasitic disease that is a major public health concern .',
  'Acute lung infection due to Pseudomonas aeruginosa ( P. aeruginosa ) is a serious problem , especially in patients with structural lung conditions or immune compromised hosts , leading to an overwhelming threat with a high risk of morbidity and mortality .',
  'Human cystic echinococcosis ( CE ) caused by infection with a larval stage of Echinococcus granulosus is a serious public health problem in Turkey .',
  'Antimicrobial resistance in Pseudomonas aeruginosa is a serious clinical problem .',
  'Intrauterine infection due to the pseudomonads poses a serious problem that has not been previously recognized .',
  'Pulmonary infections with Pseudomonas aeruginosa are a serious clinical problem and are often lethal .',
  'Prevalence of ESBLs among P. aeruginosa has been increased in recent years , demonstrate a serious health problem especially in burn units worldwide .',
  'Cystic echinococcosis is a zoonotic disease with a wide geographical distribution , Greece included , and is considered to be a serious problem for the public health and the livestock economy .',
  'Human echinococcoses are parasitic helminth infections that constitute a serious public health concern in several regions across the world .',
  'Cystic echinococcosis ( CE ) is a serious public health problem in sheep-raising regions of Turkey .',
  'The co-production of plasmid-mediated AmpC along with chromosomal Pseudomonas-derived cephalosporinases thus remain a serious clinical concern owing to high resistance spectrum towards antibiotics .',
  'Colonization of the respiratory tract with Pseudomonas aeruginosa is a serious problem in cystic fibrosis and seriously ill hospitalized patients .',
  'The cystic echinococcosis described as a young adult disease may actually observed at any age and remains a serious problem of public health in Tunisia .',
  'Childhood echinococcosis remains a serious health problem for the country .',
  'Pseudomonas aeruginosa is one of the most common causes of nosocomial infections , and its multi-drug resistance has been a serious problem worldwide .',
  'Hydatid disease caused by echinococcus granulosus is still a serious problem in both underdeveloped and developing countries .',
  'P. aeruginosa multi-resistance is a serious problem in the treatment of patients with chronic osteomyelitis .',
  'The emergence of Pseudomonas aeruginosa strains resistant to carbapenems , fluoroquinolones and amikacin , which were defined as multidrug-resistant ( MDR ) strains , is a serious problem in Japan .',
  'In Japan , MDR P. aeruginosa is becoming a serious problem in the clinical setting .',
  'In the endemic countries , human cystic echinococcosis ( CE ) poses a serious medical and social problem .',
  'The cestode Echinococcus multilocularis infection , a serious health problem worldwide , causes alveolar echinococcosis ( AE ) , a tumor-like disease predominantly located in the liver and able to spread to any organs .',
  'Cystic echinococcosis is a serious public health problem in developing countries .',
  'Pseudomonas aeruginosa ( PA ) bloodstream infection ( BSI ) is a common complication in patients with acute leukemia ( AL ) , and the prevalence of antibiotic-resistant strains poses a serious problem .',
  'Among adults with cystic fibrosis , compliance can be a serious problem that minimizes the benefits of good medical care .',
  'Pseudomonas aeruginosa chronic lung infections are the leading cause of mortality in cystic fibrosis patients , a serious problem which is notably due to the numerous P. \xa0 aeruginosa virulence factors , to its ability to form biofilms and to resist the effects of most antibiotics .',
  'Drug-resistant strains of Pseudomonas are a serious health problem , so this family of antibiotics may have important therapeutic applications .',
  'Serious infection due to strains of Pseudomonas aeruginosa that exhibit resistance to all common antipseudomonal antimicrobials increasingly is a serious problem .',
  'Echinococcosis is still a serious problem particularly in endemic areas such as South and Central America , Mediterranean countries , and Russia .',
  'Pseudomonas aeruginosa biofilm-associated infections are a serious medical problem , and new compounds and therapies acting through novel mechanisms are much needed .',
  'Management options for cystic echinococcosis ( CE ) remain a serious problem .',
  'Pseudomonas aeruginosa is a Gram negative , opportunistic biofilm forming pathogenic bacterium which is developing as a serious problem worldwide .',
  "The emergence of multidrug-resistant ( MDR ) Pseudomonas aeruginosa isolates producing IMP-type metallo-β-lactamases ( MBLs ) and aminoglycoside 6'-N-acetyltransferase [ AAC(6')-Iae ] has become a serious problem in medical settings in Japan .",
  'The emergence of colistin-resistant Pseudomonas aeruginosa is becoming a serious concern worldwide .',
  'Human echinococcosis remains a serious health problem for the Mediterranean countries , among them Greece .',
  'P. aeruginosa continues to be a serious problem worldwide as a cause of respiratory tract infections in selected populations .',
  'Pseudomonas aeruginosa is an important opportunistic pathogen that has become a serious problem due to increased rates of antibiotic resistance .',
  'Extremely drug-resistant Pseudomonas \xa0 aeruginosa strains causing severe infections have become a serious concern across the world .',
  'A vexing problem in cystic fibrosis ( CF ) pathogenesis has been to explain the high prevalence of Pseudomonas aeruginosa biofilms in CF airways .',
  'In the past decade , multidrug-resistant Pseudomonas aeruginosa ( MDRP ) infection has become a serious clinical problem , due to the limitation of drug choices to fight against the bacteria .',
  'In Algeria , cystic echinococcosis ( CE ) is a serious economic and public health problem .',
  'Cystic echinococcosis , which commonly starts during childhood or adolescence , is a serious problem of public health in Tunisia .'],
 'echinococcus': ['Human echinococcosis remains a serious health problem for the Mediterranean countries .',
  'Hydatidosis/echinococcosis ( Echinococcus granulosus infection ) is considered to be a serious problem for both public health and the livestock economy in Greece .',
  'Echinococcal disease is still a serious problem in certain parts of the world .',
  'Cystic echinococcosis , which is one of the most important helminthic infestations , is a serious life-threatening health problem in developing countries .',
  'Cystic echinococcosis due to Echinococcus granulosus is a serious public health and economic concern in India .',
  'Cystic echinococcosis due to Echinococcus granulosus is a serious public health and livestock economy problem in Libya .',
  'Human cystic echinococcosis ( CE ) is a serious public health problem in West China .',
  'Cystic echinococcosis ( CE ) , caused by Echinococcus granulosus metacestode , invokes a serious public health concern .',
  'Cystic echinococcosis due to E. granulosus is a serious public health and livestock economy problem in Libya .',
  'Currently , cystic echinococcosis ( CE ) follow-up is a serious concern among surgeons .',
  'Cardiac and pericardial echinococcosis as a life-threatening disease may present with a clear picture most of the time , however it may also become a clinical puzzle .',
  'Human cystic echinococcosis ( CE ) caused by infection with a larval stage of Echinococcus granulosus is a serious public health problem in West China .',
  'Hydatidosis ( cystic echinococcosis ) constitutes a serious public health problem in the Province of Rio Negro , Argentina .',
  'Echinococcosis continues to be a severe public health problem in this part of China because of unhygienic practices/habits and poor knowledge among the communities regarding this disease .',
  'Cystic echinococcosis ( CE ) caused by Echinococcus granulosus remains a serious problem worldwide for issues relating to public health and the economy .',
  'Alveolar echinococcus ( AE ) is a severe health problem in endemic areas .',
  'Given that cystic echinococcosis ( CE ) is a serious clinical problem in endemic countries , there is still relatively little information available on the natural history of the human disease .',
  'Liver echinococcosis is an endemic disease in some areas of the world like Middle East and is a serious problem both from social-economic and clinical-therapeutical stand-points in other areas like Mediterranean regions .',
  'Hydatid disease caused by echinococcus granulosus is still a serious problem in both underdeveloped and developing countries .',
  'Human alveolar echinococcosis ( HAE ) , caused by the larvae of Echinococcus multilocularis , is a severe parasitic disease that is a major public health concern .',
  'Human cystic echinococcosis ( CE ) caused by infection with a larval stage of Echinococcus granulosus is a serious public health problem in Turkey .',
  'Cystic echinococcosis is a zoonotic disease with a wide geographical distribution , Greece included , and is considered to be a serious problem for the public health and the livestock economy .',
  'Human echinococcoses are parasitic helminth infections that constitute a serious public health concern in several regions across the world .',
  'Cystic echinococcosis ( CE ) is a serious public health problem in sheep-raising regions of Turkey .',
  'The cystic echinococcosis described as a young adult disease may actually observed at any age and remains a serious problem of public health in Tunisia .',
  'Childhood echinococcosis remains a serious health problem for the country .',
  'Hydatid disease caused by echinococcus granulosus is still a serious problem in both underdeveloped and developing countries .',
  'In the endemic countries , human cystic echinococcosis ( CE ) poses a serious medical and social problem .',
  'The cestode Echinococcus multilocularis infection , a serious health problem worldwide , causes alveolar echinococcosis ( AE ) , a tumor-like disease predominantly located in the liver and able to spread to any organs .',
  'Cystic echinococcosis is a serious public health problem in developing countries .',
  'Echinococcosis is still a serious problem particularly in endemic areas such as South and Central America , Mediterranean countries , and Russia .',
  'Management options for cystic echinococcosis ( CE ) remain a serious problem .',
  'Human echinococcosis remains a serious health problem for the Mediterranean countries , among them Greece .',
  'In Algeria , cystic echinococcosis ( CE ) is a serious economic and public health problem .',
  'Cystic echinococcosis , which commonly starts during childhood or adolescence , is a serious problem of public health in Tunisia .'],
 'plastic': ['In semi-arid areas of China , the ridge-furrow mulched with plastic film ( RF ) cultivation system is a common water-saving agricultural technique where the shortage of water resources has become a serious problem .',
  'The accumulation of plastic waste in the environment has become a serious environmental problem worldwide .',
  'Plastic residues could accumulate in soils as a consequence of using plastic mulching , which results in a serious environmental concern for agroecosystems .',
  'Conventional petrochemical plastics have become a serious environmental problem .',
  'The coupling of bioplastics with natural fibers in order to lower costs and promote degradability is one of the primary objectives of research , above all in the packaging and agricultural sectors where large amounts of non-recyclable plastics are generated , inducing a serious problem for plastic disposal and potential accumulation in the environment .',
  'Plastics , used everyday , are mostly synthetic polymers derived from fossil resources , and their accumulation is becoming a serious concern worldwide .',
  'Considering the stable chemical and physics characteristics of plastic , regular waste management methods are not suitable for recycling economic strategy of each government , which has become a serious environmental problem .',
  'Polyvinyl alcohol ( PVA ) is used widely in industry , and associated environmental pollution is a serious problem .',
  'Among the many threats that can be recorded on sandy beaches , plastic litter represents a serious problem for these complex and endangered ecosystems .',
  'Pollution caused by accumulating plastic waste in the environment has become worldwide a serious problem .',
  'White or plastic pollution has become a serious concern to the environmentalists for the last few years .',
  'Usage of phthalates as plasticizers has resulted in worldwide occurrence and is becoming a serious concern to human health and environment .',
  'In recent years , the accumulation of synthetic plastics has led to the development of a serious environmental problem .',
  'Comparisons with other studies from freshwater and marine beaches indicated similar relevance of plastic contamination , demonstrating for the first time that plastic pollution is a serious problem in the Paraná floodplain lakes .',
  'Plastic waste management has become a serious environmental and health concern owing to large amounts of plastic deposits globally .',
  'Due to the use of heavy metals as catalysts during plastic syntheses , particularly antimony , human exposure to metal release from plastic bottles has been a serious concern in recent years .',
  'Biodegradation of synthetic polymers , in particular polyethylene terephthalate ( PET ) , is of great importance , since environmental pollution with PET and other plastics has become a severe global problem .',
  'Conventional petroleum-derived plastics represent a serious problem for global pollution because , when discarded in the environment , are believed to remain for hundreds of years .',
  'Polyurethane waste disposal has become a serious problem .',
  'Rubber residues represent a severe problem to both health and environment due to their cross-linked structure that offers a prolonged degradation rate .',
  'Todays , with the industrialization of human societies , pollution of aquatic ecosystems with plastics derivatives are a serious concern , affecting the life of their organisms .',
  'BPA is potentially a serious public health problem because of its widely detected presence in the human body .',
  'Although contamination of the marine ecosystems by plastics is becoming recognised as a serious pollution problem , there are few studies that demonstrate the contribution made by freshwater catchments .',
  'The adverse biological and ecological consequences of plastic debris have become a serious problem worldwide .',
  'Globally , environmental pollution by plastic waste has become a severe ecological and social problem worldwide .',
  'Plastic wastes , which cause a serious environmental problem in urban areas , can serve as sources of energy .',
  'Plastics pollution has been recognized as a serious environmental problem .',
  'Plastic solid waste has become a serious problem when considering the disposal alternatives following the sequential hierarchy of sound solid waste management .',
  'The low degradability of petroleum-based polymers and the massive use of these materials constitute a serious problem because of the environmental pollution that they can cause .',
  'Plastic residues have become a serious environmental problem in areas where agricultural plastic film are used intensively .',
  'Polyethylene materials are a serious environmental concern as their nondegradable nature allows them to persist in the environment .',
  'The packing materials exhibit a considerable improvement in column efficiency , as demonstrated on the separation of polyaromatic hydrocarbons ( PAHs ) having a relatively long retention time , which thus far has been a serious problem of polymer-based packing materials .'],
 'plastics': ['In semi-arid areas of China , the ridge-furrow mulched with plastic film ( RF ) cultivation system is a common water-saving agricultural technique where the shortage of water resources has become a serious problem .',
  'The accumulation of plastic waste in the environment has become a serious environmental problem worldwide .',
  'Microplastics ( MPs ) have become a severe concern in marine environment worldwide .',
  'Plastic residues could accumulate in soils as a consequence of using plastic mulching , which results in a serious environmental concern for agroecosystems .',
  'Conventional petrochemical plastics have become a serious environmental problem .',
  'The coupling of bioplastics with natural fibers in order to lower costs and promote degradability is one of the primary objectives of research , above all in the packaging and agricultural sectors where large amounts of non-recyclable plastics are generated , inducing a serious problem for plastic disposal and potential accumulation in the environment .',
  'Plastics , used everyday , are mostly synthetic polymers derived from fossil resources , and their accumulation is becoming a serious concern worldwide .',
  'In recent years , microplastics in oceans have become a serious environmental problem and the focus of attention .',
  'The occurrence and accumulation of microplastics in wildlife and humans have become a serious global scale concern over the last decade .',
  'Considering the stable chemical and physics characteristics of plastic , regular waste management methods are not suitable for recycling economic strategy of each government , which has become a serious environmental problem .',
  'Increased pollution by plastics has become a serious global environmental problem , but the concerns for human health have been raised after reported presence of microplastics ( MPs ) and nanoplastics ( NPs ) in food and beverages .',
  'Polyvinyl alcohol ( PVA ) is used widely in industry , and associated environmental pollution is a serious problem .',
  'Among the many threats that can be recorded on sandy beaches , plastic litter represents a serious problem for these complex and endangered ecosystems .',
  'Pollution caused by accumulating plastic waste in the environment has become worldwide a serious problem .',
  'In recent decades , microplastic ( MP ) pollution has become a severe problem in aquatic environments .',
  'White or plastic pollution has become a serious concern to the environmentalists for the last few years .',
  'Usage of phthalates as plasticizers has resulted in worldwide occurrence and is becoming a serious concern to human health and environment .',
  'In recent years , the accumulation of synthetic plastics has led to the development of a serious environmental problem .',
  'Comparisons with other studies from freshwater and marine beaches indicated similar relevance of plastic contamination , demonstrating for the first time that plastic pollution is a serious problem in the Paraná floodplain lakes .',
  'Plastic waste management has become a serious environmental and health concern owing to large amounts of plastic deposits globally .',
  'Due to the use of heavy metals as catalysts during plastic syntheses , particularly antimony , human exposure to metal release from plastic bottles has been a serious concern in recent years .',
  'Biodegradation of synthetic polymers , in particular polyethylene terephthalate ( PET ) , is of great importance , since environmental pollution with PET and other plastics has become a severe global problem .',
  'Micro/nanoplastics are ubiquitous in the environment and cause pollution of the aquatic ecosystem , in particular , which is a serious concern worldwide .',
  'Conventional petroleum-derived plastics represent a serious problem for global pollution because , when discarded in the environment , are believed to remain for hundreds of years .',
  'Polyurethane waste disposal has become a serious problem .',
  'Rubber residues represent a severe problem to both health and environment due to their cross-linked structure that offers a prolonged degradation rate .',
  'The large proportion of the waste and resistance to degradation means micro- and nanoplastics have become a serious global environmental problem , but there are few studies on their potential toxicity for human health .',
  'Todays , with the industrialization of human societies , pollution of aquatic ecosystems with plastics derivatives are a serious concern , affecting the life of their organisms .',
  'BPA is potentially a serious public health problem because of its widely detected presence in the human body .',
  'As an emerging environmental pollutant , microplastics ( MPs ) are increasingly viewed as a serious health concern to terrestrial and aquatic ecosystems .',
  'Although contamination of the marine ecosystems by plastics is becoming recognised as a serious pollution problem , there are few studies that demonstrate the contribution made by freshwater catchments .',
  'Microplastic ( 0.001 - 5 \xa0 mm ) is a serious problem for the environment and is globally distributed .',
  'The adverse biological and ecological consequences of plastic debris have become a serious problem worldwide .',
  'These results indicate that microplastic accumulation on shorelines in the northern Gulf of Mexico may be a serious concern , and suggest that exposure to inputs from the Gulf is an important determinant of microplastic abundance .',
  'Globally , environmental pollution by plastic waste has become a severe ecological and social problem worldwide .',
  'Microplastic pollution ( plastics with particle sizes<5 mm ) has become a serious problem .',
  'The abundant presence and extensive use of polystyrene microplastics ( PSMPs ) has recently become a serious environmental concern , as impact of exposure to these substances on human health remains unknown .',
  'Plastic wastes , which cause a serious environmental problem in urban areas , can serve as sources of energy .',
  'Plastics pollution has been recognized as a serious environmental problem .',
  'Plastic solid waste has become a serious problem when considering the disposal alternatives following the sequential hierarchy of sound solid waste management .',
  'The low degradability of petroleum-based polymers and the massive use of these materials constitute a serious problem because of the environmental pollution that they can cause .',
  'Plastic residues have become a serious environmental problem in areas where agricultural plastic film are used intensively .',
  'Polyethylene materials are a serious environmental concern as their nondegradable nature allows them to persist in the environment .',
  'The packing materials exhibit a considerable improvement in column efficiency , as demonstrated on the separation of polyaromatic hydrocarbons ( PAHs ) having a relatively long retention time , which thus far has been a serious problem of polymer-based packing materials .'],
 'escherichia': ['Infection with Shiga toxin-producing ( Stx ) Escherichia coli ( STEC ) currently represents a serious public health problem due to its life-threatening complications : hemorrhagic colitis and hemolytic uremic syndrome .',
  'Human illness due to infections with Escherichia coli O157 is a serious health concern .',
  'High prevalence of diarrheagenic E. coli compounded by alarming antimicrobial resistances is a serious public health problem .',
  'Gastrointestinal infections are considered a serious public health problem in view of their high incidence and the increasing antibiotic resistance of the microorganisms involved in their pathogenesis , namely Escherichia coli .',
  'Diarrhea-causing Escherichia coli strains are responsible for numerous cases of gastrointestinal disease and constitute a serious health problem throughout the world .',
  'The pool of antimicrobial resistance determinants in the environment and in the gut flora of cattle is a serious public health concern .',
  'Shiga toxin-producing Escherichia coli ( STEC ) food-borne infections are reported worldwide and represent a serious problem for public healthcare .',
  'Human illness due to contamination of food by pathogenic strains of Escherichia coli is a serious public health concern and can cause significant economic losses in the food industry .',
  'Escherichia coli O157:H7 can cause life-threatening gastrointestinal diseases and has been a severe public health problem worldwide in recent years .',
  'Persistence of E. coli O157 in the environment is a serious public health concern .',
  'It is concluded that aminoglycoside resistance in E. coli from broilers with septicaemia remains a serious problem in Hebei , China .',
  'Foodborne diseases are a serious and growing problem , and the incidence and prevalence of antimicrobial resistance among foodborne pathogens is reported to have increased .',
  'The emerging of antimicrobial-resistant foodborne bacteria is a serious public health concern worldwide .',
  'Escherichia coli O157:H7 is a gastrointestinal pathogen that has become a serious public health concern , as it is associated with outbreaks and severe diseases such as hemolytic-uremic syndrome .',
  'Escherichia coli is considered a serious public health problem .',
  'Infections with shiga toxin-producing bacteria , like enterohemorrhagic Escherichia coli and Shigella dysenteriae , represent a serious medical problem .',
  'Recent foodborne E. coli outbreaks has left a serious concern to public health .',
  'Contamination of the environment with human sewage represents a serious public health concern in which Escherichia coli plays a central role , either directly as a human pathogen or indirectly through its use as an indicator organism .',
  'These results suggest that the His6-EMA1 protein expressed in E. coli could be a reliable immunodiagnostic antigen for ELISA test and that T. equi infection is a serious concern in the State of São Paulo , Brazil .',
  'Colisepticemia caused by bloodstream infection of the extraintestinal pathogenic Escherichia coli ( ExPEC ) has become a serious public health problem .',
  'Escherichia coli strains are responsible for many cases of gastrointestinal disease and represent a serious health problem worldwide .',
  'The transmission of antimicrobial resistance genes from enteric bacteria from the animal reservoir to indigenous bacteria in meat is a serious concern , as it can contribute to human exposure to antimicrobial resistance genes .',
  'Entero aggregative Escherichia coli ( EAEC ) is an emerging enteric pathogen associated with acute and persistent diarrhea and the evolution and spread of acquired extended spectrum betalactamases ( ESBLs ) among these strains has become a serious problem in the management of infectious diseases in developing countries .',
  'Food-borne pathogens are a serious human health concern worldwide , and the emergence of antibiotic-resistant food pathogens has further confounded this problem .',
  'Shiga toxin-producing Escherichia coli ( STEC ) are zoonotic foodborne and waterborne pathogens that are a serious public health concern because they cause outbreaks and the potentially fatal hemolytic uremic syndrome ( HUS ) .',
  'The present findings clearly demonstrate that antibiotic-resistant bacteria in beef and milk pose a serious problem in South Africa .',
  'Human infections with Escherichia coli O157:H7 and Salmonella enterica linked to fresh vegetable consumption have become a serious public health problem inflicting a heavy economic burden .',
  'Infection caused by enterotoxigenic Escherichia coli ( ETEC ) poses a serious health problem to children in developing countries .',
  'Infection caused by enterotoxigenic Escherichia coli ( ETEC ) poses a serious health problem among children and adults in developing countries .',
  'Enterohemorrhagic Shiga toxin (Stx)-producing Escherichia coli ( EHEC ) infections are a serious public health problem , and Stx is the main pathogenic agent associated with typical hemolytic-uremic syndrome ( HUS ) .',
  'Multiple antibiotic-resistant extra-intestinal pathogenic Escherichia coli ( ExPEC ) strains represent a serious health care problem both for poultry and humans .',
  'The presence of multidrug-resistant Escherichia coli of fecal origin in seafood is a serious concern .',
  'The potential presence of human pathogens in vegetables grown in soils contaminated with E. coli O157:H7 is a serious problem to our national food supply as the pathogen may survive on the leaf surface as they come in contact with contaminated soil during germination .',
  'Infection with Shiga toxin (Stx)-producing Escherichia coli ( STEC ) is a serious public health concern , causing severe diarrhea and hemolytic-uremic syndrome .',
  'Foodborne illness outbreaks resulting from contamination of Escherichia coli O157:H7 remain a serious concern in food safety .'],
 'biofilm': ['The nonspecific adsorption of proteins and bacteria on the surface of polydimethylsiloxane ( PDMS ) had been a serious concern in a wide range of applications , such as medical devices .',
  'The development of multi-species biofilms in chronic wounds is a serious health problem that primarily generates strong resistance mechanisms to antimicrobial therapy .',
  'Therefore , the biofilm formation , especially by multidrugresistant pathogens , is a serious medical problem , playing a pivotal role in the development of chronic and recurrent infections .',
  'Biofilms pose a serious problem for public health because of the increased resistance of biofilm-associated organisms to antimicrobial agents and the potential for these organisms to cause infections in patients with indwelling medical devices .',
  'Bacterial biofilms on implanted medical devices are a serious problem .',
  'High resistance of biofilms for chemical challenges is a serious industrial and medical problem .',
  'Biofilm formation in wounds is a serious problem which inhibits proper wound healing .',
  'Biofilm formation by Staphylococcus aureus is a serious problem in nosocomial infections .',
  'Device-associated infections ( DAI ) remain a serious concern in modern healthcare .',
  'Bacterial infection of biomaterials is a serious problem in the field of medical devices .',
  'Bacterial cells at biofilm stage also are more tolerant to sanitizers compared   with their planktonic counterparts , which makes STEC biofilms a serious food safety concern .',
  'Nosocomial infections caused by biofilm-positive microorganisms are a serious therapeutic problem .',
  'Bacterial biofilms are a serious global health concern , often responsible for persistent infections .',
  'Biofilm formation in association with the intercellular adhesion ( icaADBC ) gene cluster is a serious problem in nosocomial infections of Staphylococcus aureus .',
  'Biofilm formation by Salmonella is a serious concern in the food-processing industry and the persistence of the organism in biofilms becomes a constant source of contamination .',
  'It represents a serious problem for the food industry because of its environmental persistence mainly due to its ability to form biofilm on a variety of surfaces .',
  'Nowadays , the resistance of bacterial biofilms towards the available antibiotics is a severe problem .',
  'Infection of implanted medical devices by Gram-positive organisms such as Staphylococcus ssp . is a serious concern in the biomaterial community .',
  'Biofilms are considered as a severe problem in the treatment of bacterial infections ; their development causes some noticeable resistance to antibacterial agents .',
  'Bacterial biofilm cells are usually more resistant to sanitization than their planktonic counterparts , so these foodborne pathogens in biofilms pose a serious food safety concern .',
  "Biofilms ' tolerance has become a serious clinical concern due to their formidable resistance to conventional antibiotics and prevalent virulence .",
  'Bacterial adhesion infection caused by medical materials in clinical application has become a serious threat , and it urgently needs new strategies to deal with these clinical challenges .',
  'Bacterial adhesion to the calcium phosphate surface is a serious problem in surgery .',
  'Biofilms formed by Proteus mirabilis strains are a serious medical problem , especially in the case of urinary tract infections .',
  'Bacterial adhesion infection caused by medical materials in clinical application has become a serious threat , and it urgently needs new strategies to deal with these clinical challenges .',
  'These biofilms entail a serious problem in daily clinical practice because of the great prevalence of implantable device-related infections .',
  'Biofilms are a serious problem of public health , because biofilm-associated microorganisms exhibit increased resistance to antibiotics .',
  'Biofilms are associated with a wide variety of bacterial infections and pose a serious problem in clinical medicine due to their inherent resilience to antibiotic treatment .',
  'Nevertheless , fatal bacterial infections are still a serious problem when CTS nanofibers are used for wound treatment .',
  'Biofilm-associated infections in the medical devices pose a serious problem to the public health and adversely affect the function of the device .',
  'Candida biofilm can form on the surface of plastic materials ( silicon , polychloride vinyl , polymethacrylate methyl ) used to catheters , drains and dentures production that is why it is a serious problem in case of fungal infections in patients who during the diagnosis and treatment have contact with biomaterials .',
  'Infections resulting from the attachment of bacteria and biofilm formation on the surface of medical implants give rise to a severe problem for medical device safety .',
  'Staphylococcus aureus biofilms formed on medical implants represent a serious problem , being difficult to eradicate with antibiotic therapy and leading to chronic infections .',
  'Biofilm infections present a serious problem because antibacterial drugs are not effective against mature biofilms or biofilms formed by drug-resistant bacteria .',
  'Biofilm formation on orthodontic adhesives is a serious clinical problem , as it leads to enamel demineralization around fixed orthodontic appliances , often leaving white spot lesions after their removal .',
  'Biofilm-associated implant infections represent a serious public health problem .',
  'Biofilms are a serious problem , cause of severe inconvenience in the biomedical , food and industrial environment .',
  'Biofilms in the food-processing industry are a serious concern due to the potential for contamination of food products , which may lead to decreased food quality and safety .',
  'This makes biofilms a serious problem in clinical settings .',
  'Staphylococcus aureus and its biofilm formation are recognized as a serious clinical problem .',
  'In Staphylococcus aureus ( S. aureus ) , biofilms are implicated in the resilience of chronic infections , presenting a serious clinical problem world-wide .',
  'Biofilms represent a serious problem for food industries due to their persistence in processing surfaces , from which they can cause food spoilage or , even worse , lead to foodborne diseases .',
  'Biofilm infections present a serious problem in human medicine as they often lead to bacterial persistence and thus to chronic infections .',
  'These microbial cells with extracellular polymeric substances \xa0 colonize living and nonliving surfaces and \xa0 pose \xa0 a serious problem for all industries , affecting their processes , leading to a reduction of product quality and economic loss .',
  'Bacterial infection on biomaterial devices and the subsequent medical risks pose a serious problem in both human healthcare and industrial applications , resulting in a prevalence of various antimicrobial materials .',
  'Bacterial infection has become a serious clinical concern due to the emergence of drug-resistance and biofilm formation .',
  'In the meat industry , biofilms remain a serious concern because many foodborne pathogens can form biofilms in areas at meat plants that are difficult to sanitize properly , and biofilm cells are more tolerant to sanitization than their planktonic counterparts .',
  'The rise of antibiotic resistance among biofilm-producer strains demonstrates a serious concern about limited treatment options in the \xa0 hospital settings .',
  'Given these anti-biofilm properties and considering that biofilm formation is a serious problem for the food industry and human health , PEOVW has proved to be a high-value natural product .',
  'Bacterial adhesion and subsequent biofilm formation on material surfaces represent a serious problem in society from both an economical and health perspective .',
  'Biofilm formation on medical implants and devices has been a severe concern that results in their impaired performance and life-threatening complications .',
  'Biomaterial-associated infections remain a serious concern in modern healthcare .',
  'Biofilms are the leading cause of microbial infections in humans , thus representing a serious problem in health care .',
  'Biofilm formation on foods and food industrial equipment is a serious problem causing food spoilage and emergence of foodborne diseases .',
  'Bacterial attachment and the subsequent formation of biofilm on surfaces of synthetic materials pose a serious problem in both human healthcare and industrial applications .',
  'Biofilm-related infections represent a serious health problem , accounting for 65- 80 % of all infections .',
  'Bacterial biofilms pose a serious medical problem due to their significant resistance to antimicrobials , and staphylococci are recognized as the most frequent cause of biofilm-associated infections .',
  'It is widely acknowledged that biofilm has become a serious problem in the food industry , as the biofilm growth mode induces microbial resistance to chemical disinfection .',
  'Antimicrobial oligo ( p-phenylene-ethynylene ) ( OPE ) films have previously been demonstrated to show effective ultraviolet A ( UVA ) light-induced biocidal activity ; however , a serious problem arises from the accumulation of dead bacteria and debris on the films that limits their effectiveness and application .',
  'Biofilm tolerance has become a serious clinical concern in the treatment of nosocomial pneumonia owing to the resistance to various antibiotics .',
  'This matrix , together with cell proximity , confers many advantages to these microbial communities , but also constitutes a serious concern when biofilms develop in human tissues or on implanted prostheses .',
  'Because periprosthetic infection remains a vexing problem for patients receiving implanted devices , we evaluated the effect of several materials on neutrophil free radical production .',
  'Biofilm represents a serious problem in food industry , since it is a constant and important contamination source and also , bacteria present in it have an increased resistance towards physical and chemical agents of common use .',
  'Bacterial biofilm development is a serious problem in many fields , and the existing biofilm monitoring sensors often turn out to be inadequate .'],
 'vitamin': ['In parallel , an increase in some pathological alterations caused by the deficit of some micronutrients present in dairy products , mainly calcium and vitamin D , has been detected , resulting in a serious public health problem in certain groups of population .',
  'In Peru , Honduras , Argentina , Ecuador , and Brazil , vitamin A deficiency is a moderate public health problem ( prevalence from 14.0 % to 17.4 % ) , while in Colombia , Mexico , and Haiti it is a severe public health problem ( prevalence from 24.3 % to 32.0 % ) .',
  'Among mothers , 27 % had chronic energy deficiency ( body mass index , < 18.5 kg/m(2 ) ) and 20 % were night blind , indicating that vitamin A deficiency was a serious problem .',
  'Vitamin A deficiency is recognized to be a severe public health problem in most of the sahelian countries .',
  'Public health : Although the availability of vitamin A through food fortification and medicinal supplements virtually eliminated ocular vitamin A deficiency from developed countries by the second half of the 20th century , vitamin A deficiency remains a serious problem in developing countries as indicated by global surveys beginning in the 1960s .',
  'This dilemma represents a serious problem in many populations , for an association of vitamin D-deficiency and multiple independent diseases has been convincingly demonstrated .',
  '25-hydroxy vitamin D [ 25(OH ) vit D ] deficiency is a serious public health problem , particularly in the Indian sub-continent .',
  'Vitamin-A deficiency is a severe public health problem in the study area .',
  'Vitamin A deficiency ( VAD ) is a serious and widespread public health problem in developing countries .',
  'Several surveys conducted over a period of 40 years have shown that vitamin A deficiency is a serious public health problem in Ethiopia .',
  'According to international criteria , the national prevalence of marginal vitamin A status found in the survey identifies the country as having a serious public health problem of vitamin A deficiency .',
  'Vitamin D deficiency is a serious health problem among large population groups in Europe .',
  'This dilemma represents a serious problem in many populations , for an association of vitamin D-deficiency and multiple independent diseases including various types of cancer has been convincingly demonstrated .',
  'Marginal vitamin A deficiency ( MVAD ) is a serious and widespread public health problem among pregnant women and children in developing countries .',
  'Vitamin D deficiency , a preventable disorder , is a common and important public health problem for older disabled women living in the community ; black women are at higher risk than are white women .',
  'Vitamin A deficiency ( VAD ) is a serious and widespread public health problem and the leading cause of preventable blindness in young children .',
  'Mild or marginal vitamin A deficiency ( MVAD ) is still a serious and widespread public health problem in pregnant women and children in developing countries .',
  'Vitamin A insufficiency among Chongqing urban school-age children was found to be a severe health problem , significantly associated with obesity , hypertriglyceridemia and MS .',
  'Vitamin D deficiency is a serious public health problem worldwide that affects not only skeletal health , but also a wide range of acute and chronic diseases .',
  'In sub-Saharan Africa , vitamin A deficiency constitutes a severe health problem despite various supplementation and food fortification programs .',
  'In particular , vitamin A deficiency , a severe health problem affecting the lives of millions in developing countries , has triggered the development of a series of high-provitamin A crops , including Golden Rice as the best-known example .',
  'Although Turkey is located in a sunny region , vitamin D deficiency is still a serious health problem in pregnant women and their infants , especially among the low socio-economic status Turkish population .',
  'Biochemical vitamin A deficiency ( VAD ) is believed to be a serious public health problem ( low serum retinol prevalence \xa0 > 20 % ) in Indian children , justifying universal high-dose vitamin A supplementation ( VAS ) .',
  'from this study demonstrated that vitamin A deficiency among children under 5 years old appeared to be a serious public health problem in the poor rural areas of 6 Western Chinese provinces .',
  'Vitamin A ( VA ) deficiency remains a serious problem in the world today .',
  'Vitamin D deficiency has been highlighted as a serious public health problem in the United Kingdom .',
  'Xerophthalmia due to vitamin A deficiency is a leading cause of blindness in children and has been a serious problem in Indonesia .',
  'Vitamin A deficiency ( VAD ) is a serious and widespread public health problem in the Philippines .',
  'Vitamin D deficiency is becoming a serious public health problem , even in sun-drenched cities like Karachi , Pakistan .',
  'Vitamin A deficiency is a serious health problem in Bangladesh .',
  'The prevalence of vitamin A deficiency was 72 % , indicating a severe public health problem .',
  'Nutritional vitamin B₁₂ deficiency due to maternal deficiency might be a serious health problem in infants .',
  'These data suggest that Vitamin A deficiency is still a serious public health problem in rural areas of the Congo in which this study was carried out .',
  'Dietary vitamin B12 deficiency is a severe problem in the Indian subcontinent , Mexico , Central and South America , and selected areas in Africa .',
  'Vitamin A deficiency is still a serious public health problem affecting an estimated 127 million preschool children .',
  'Vitamin A deficiency is a serious problem throughout the developing world .',
  'Vitamin D insufficiency could be a serious problem in patients with high dose glucocorticoid therapy .',
  'Recent national data indicated an inverse association between vitamin D status and coronary heart disease ( CHD ) , which increases concerns about vitamin D deficiency as a serious public health problem .',
  'The observational studies conducted by our group revealed that vitamin D insufficiency does not seem to be a serious problem among active elderly people , but that elderly people with a low level of activities of daily living ( ADL ) are at a very high risk of vitamin D insufficiency .',
  'Vitamin D insufficiency is a serious problem in the study population , and living near the Equator does not assure adequate vitamin D status .',
  'Vitamin A deficiency is a serious global health problem that can be alleviated by improved nutrition .',
  'These data define vitamin A deficiency as a severe public health problem in the Bandiagara area of Mali .',
  'Thus , predominant rice consumption promotes vitamin A deficiency , a serious public health problem in at least 26 countries , including highly populated areas of Asia , Africa , and Latin America .',
  'Vitamin D deficiency is a preventable health problem .',
  'There is a serious public health problem of low vitamin D status .',
  'Among 8 studies on subclinical vitamin A deficiency , 7 of them indicated a severe public health problem ( > 20 % ) .',
  'Vitamin A deficiency : a serious nutritional problem in many areas of the world today .',
  'Vitamin D deficiency is a serious global health problem .',
  'Ca deficiency was discovered to be a serious health problem for rural children , with Ca inadequacies reaching 96 % .',
  'This dilemma represents a serious problem , for an association of vitamin D-deficiency and multiple independent diseases including various types of cancer , bone diseases , autoimmune diseases , infectious diseases , cardiovascular diseases and hypertension has now been reported in a large number of laboratory and epidemiologic investigations .',
  "With vitamin D deficiency as a serious public health problem , vitamin D status at birth was measured in neonates at latitude 32 degrees 72 ' ( southeastern United States ) .",
  "Xerophthalmia prevalence ranged from 1.6 % to 4.4 % for nightblindness and 0.6 % to 2.7 % for Bilot 's spots in the three provinces indicating a serious vitamin A deficiency problem .",
  'Vitamin D deficiency is a serious health problem despite a general improvement in socio-economic status in Turkey .',
  'Vitamin D deficiency is a serious health problem with numerous health consequences ; it is associated with diabetes , rheumatic arthritis , Parkinson , Alzheimer diseases , osteomalacia , osteoporosis , and fractures in adults and cancers .',
  'Vitamin A deficiency is a serious health problem in many developing countries .',
  'Vitamin D deficiency ( VDD ) is emerging as a serious public health problem globally ; however due to lack of resources , vitamin D levels are not routinely measured among neonates .',
  'The rise in maternal obesity highlights that maternal and newborn vitamin D deficiency will continue to be a serious public health problem until steps are taken to identify and treat low 25(OH)D.',
  'This dilemma represents a serious problem , for an association of vitamin D-deficiency and multiple independent diseases including various types of cancer , bone diseases , autoimmune diseases , infectious diseases , cardiovascular diseases and hypertension has now been reported in a large number of investigative and epidemiologic studies .',
  'On the other hand , vitamin D deficiency ( VDD ) is also a serious public health problem with significant impacts and multiple health effects .',
  'Vitamin A deficiency is a serious nutritional problem , causing multiple adverse health outcomes .',
  'Vitamin A deficiency was still a serious health problem in children in China cities .',
  'These results confirm the presence of a serious public health problem with regard to vitamin D amongst veiled women .',
  'Vitamin A ( VA ) deficiency is a serious public health problem , especially in preschool children who are at risk of increased mortality .'],
 'snakebite': ['Snakebites are a serious worldwide public health problem .',
  'Accidents involving snakebites constitute a serious public health problem in many regions around the world .',
  'Snakebite envenomation is a serious medical problem in many developing tropical and subtropical countries .',
  'Snakebites are a serious public health problem and , in the Amazon , the',
  'In North Cameroon , venom inoculations by Echis Carinatus are frequent and severe and thus pose a serious problem at Public Health Services .',
  'Snake bites represent a serious public health problem , particularly in rural areas worldwide .',
  'Intoxication of the population of Guinea due to venomous snake bites ( 100 - 150 intoxications per 100,000 with an 18 % mortality rate ) is a serious public health problem in the Republic of Guinea .',
  'Although venomous snakebites are not a serious world wide problem from the epidemiological point of view and are rare under our conditions , it is frequently a very serious and life threatening matter .',
  'Envenomation from bite of exotic snakes is rare in France and represent a serious therapeutic problem : only an adapted antivenom is effective and obtaining such a treatment is a real difficulty .',
  'However , despite these efforts a lone snakebite diagnostic kit is available until now which is a severe concern for efficacious snakebite therapy .',
  'Snakebite is a severe problem in many parts of the world , specifically in tropical and subtropical regions .',
  'Snakebites is a neglected disease and in Brazil is considered a serious health problem , with the majority of the snakebites caused by the genus Bothrops .',
  'Snakebite envenomation is a serious medical problem in many tropical developing countries and was considered by WHO as a neglected tropical disease .',
  'Hemiscorpius lepturus envenomation is recognized as a serious health concern in tropical regions .',
  'A snakebite is a serious and important problem in tropical and subtropical cities .',
  'Snakebite is a serious medical and socio-economic problem affecting the healthy individuals and agricultural and farming populations worldwide .',
  'Uncertainty as to the species diagnosis remains a serious problem in the management of snake venom poisoning .',
  'Snakebite envenoming is a serious public health problem in Central America , where approximately 5,500 cases occur every year .',
  'Snakebite is a serious medical and socio-economic problem affecting the rural and agricultural laborers of tropical and sub-tropical region across the world leading to high morbidity and mortality .',
  'Systemic envenomation represents a serious medical problem with antivenom , which is raised against Acanthophis antarcticus venom , representing the primary treatment .',
  'Snakebite envenoming is a serious and life-threatening but neglected problem in the tropics .',
  'Although low case fatality and mortality rates were observed , much can still be done to prevent snakebites as they continue to be a serious public health problem considering the severity and potentially high economic impact for the individual and to society .',
  'Snakebite is a serious problem in rural India where several highly venomous species are commonly found in and around agricultural areas where prey such as rodents and amphibians are abundant .',
  'Myonecrosis is a serious result of rattlesnake bite and constitutes a persistent clinical problem .',
  'Snakebites are a serious medical , social , and economic problem that are experienced worldwide ; however , they are most serious in tropical and subtropical countries .',
  'Mortality due to snake envenomation is not a major problem in the United States with approximately 8 - 12 deaths per year , but envenomation is a serious problem that can result in functional disability , loss of extremities , and a costly recovery .',
  'Mortality due to snakebite is a serious public health problem , and available therapeutics are known to induce debilitating side effects .',
  'Snakebites are a serious public health problem due their high morbi-mortality .',
  'Snakebites represent a serious global public health problem , especially in tropical countries .',
  'Snakebite envenoming is a serious medical problem in different areas of the world .',
  'Morbidity and mortality due to envenoming by the carpet viper ( Echis ocellatus ) in northern Nigeria remains unacceptably high and constitutes a severe economic and public health problem to the local farming community in particular .',
  'Snakebites are a serious problem in public health due to their high morbimortality .',
  'Snakebite envenomings constitute a serious and neglected public health problem .',
  'Traditional medicine is an invaluable source of research into new medicines as a supplement for the treatment of snakebite , considered as a serious public health problem worldwide .',
  'Thirty-one consecutive cases of snake bite were studied in the Benue Valley , Nigeria where carpet viper ( Echis carinatus ) bite constitutes a serious health problem .',
  'Trimeresurus bite is a serious medical problem in Asia .',
  'Brown recluse spider bites are a serious medical problem in the southeastern United States .',
  'Snake bites represent a serious public health problem in many areas of the world .',
  'Injuries caused by venomous animals affect vast areas of Latin America , Southern Asia , Southeast Asia , sub-Saharan Africa , and Oceania , and pose a serious problem for global public health .',
  'In the production of current therapeutic antisera used in Argentina for Bothrops snakebite , the Bothrops moojeni venom is not used as immunogen , since this snake is not considered a serious public health problem .',
  'Snakebite envenomation is a serious public health concern in rural areas of Uganda .',
  'While in some countries of origin the high incidence of envenomations by dangerous arachnids can result in a serious problem to the health system , we assessed the risk that the same species pose when kept as pets under controlled maintenance conditions as significantly lower .',
  'Snakebites are a serious health problem in tropical countries .',
  'Snakebites constitute a serious public health problem in Central and South America , where species of the lancehead pit vipers ( genus Bothrops ) cause the majority of accidents .',
  'Snakebite is a serious medical problem in',
  "Snakebite is a severe medical , social , and economic problem in many parts of the world , chiefly in tropical and subtropical nations where majority of the world 's dangerous snakes are found and where access to treatment is limited .",
  'Snakebite envenoming is a serious problem in Myanmar .',
  'Snakebite envenoming is a serious global public health problem , and international initiatives , under the coordination of the World Health Organization and its regional offices , are being developed to reduce the impact of this neglected tropical disease .',
  'Envenomations constitute a serious public health problem in many developing countries .',
  'Envenomings by elapid snakes of the genus Dendroaspis , collectively known as mambas , represent a serious medical problem in sub-Saharan Africa .'],
 'snakebites': ['Snakebites are a serious worldwide public health problem .',
  'Accidents involving snakebites constitute a serious public health problem in many regions around the world .',
  'Snakebite envenomation is a serious medical problem in many developing tropical and subtropical countries .',
  'Snakebites are a serious public health problem and , in the Amazon , the',
  'In North Cameroon , venom inoculations by Echis Carinatus are frequent and severe and thus pose a serious problem at Public Health Services .',
  'Snake bites represent a serious public health problem , particularly in rural areas worldwide .',
  'Intoxication of the population of Guinea due to venomous snake bites ( 100 - 150 intoxications per 100,000 with an 18 % mortality rate ) is a serious public health problem in the Republic of Guinea .',
  'Although venomous snakebites are not a serious world wide problem from the epidemiological point of view and are rare under our conditions , it is frequently a very serious and life threatening matter .',
  'Envenomation from bite of exotic snakes is rare in France and represent a serious therapeutic problem : only an adapted antivenom is effective and obtaining such a treatment is a real difficulty .',
  'However , despite these efforts a lone snakebite diagnostic kit is available until now which is a severe concern for efficacious snakebite therapy .',
  'Snakebite is a severe problem in many parts of the world , specifically in tropical and subtropical regions .',
  'Snakebites is a neglected disease and in Brazil is considered a serious health problem , with the majority of the snakebites caused by the genus Bothrops .',
  'Snakebite envenomation is a serious medical problem in many tropical developing countries and was considered by WHO as a neglected tropical disease .',
  'Hemiscorpius lepturus envenomation is recognized as a serious health concern in tropical regions .',
  'A snakebite is a serious and important problem in tropical and subtropical cities .',
  'Snakebite is a serious medical and socio-economic problem affecting the healthy individuals and agricultural and farming populations worldwide .',
  'Uncertainty as to the species diagnosis remains a serious problem in the management of snake venom poisoning .',
  'Snakebite envenoming is a serious public health problem in Central America , where approximately 5,500 cases occur every year .',
  'Snakebite is a serious medical and socio-economic problem affecting the rural and agricultural laborers of tropical and sub-tropical region across the world leading to high morbidity and mortality .',
  'Systemic envenomation represents a serious medical problem with antivenom , which is raised against Acanthophis antarcticus venom , representing the primary treatment .',
  'Snakebite envenoming is a serious and life-threatening but neglected problem in the tropics .',
  'Although low case fatality and mortality rates were observed , much can still be done to prevent snakebites as they continue to be a serious public health problem considering the severity and potentially high economic impact for the individual and to society .',
  'Snakebite is a serious problem in rural India where several highly venomous species are commonly found in and around agricultural areas where prey such as rodents and amphibians are abundant .',
  'Myonecrosis is a serious result of rattlesnake bite and constitutes a persistent clinical problem .',
  'Snakebites are a serious medical , social , and economic problem that are experienced worldwide ; however , they are most serious in tropical and subtropical countries .',
  'Mortality due to snake envenomation is not a major problem in the United States with approximately 8 - 12 deaths per year , but envenomation is a serious problem that can result in functional disability , loss of extremities , and a costly recovery .',
  'Mortality due to snakebite is a serious public health problem , and available therapeutics are known to induce debilitating side effects .',
  'Snakebites are a serious public health problem due their high morbi-mortality .',
  'Snakebites represent a serious global public health problem , especially in tropical countries .',
  'Snakebite envenoming is a serious medical problem in different areas of the world .',
  'Morbidity and mortality due to envenoming by the carpet viper ( Echis ocellatus ) in northern Nigeria remains unacceptably high and constitutes a severe economic and public health problem to the local farming community in particular .',
  'Snakebites are a serious problem in public health due to their high morbimortality .',
  'Snakebite envenomings constitute a serious and neglected public health problem .',
  'Traditional medicine is an invaluable source of research into new medicines as a supplement for the treatment of snakebite , considered as a serious public health problem worldwide .',
  'Thirty-one consecutive cases of snake bite were studied in the Benue Valley , Nigeria where carpet viper ( Echis carinatus ) bite constitutes a serious health problem .',
  'Trimeresurus bite is a serious medical problem in Asia .',
  'Brown recluse spider bites are a serious medical problem in the southeastern United States .',
  'Snake bites represent a serious public health problem in many areas of the world .',
  'Injuries caused by venomous animals affect vast areas of Latin America , Southern Asia , Southeast Asia , sub-Saharan Africa , and Oceania , and pose a serious problem for global public health .',
  'In the production of current therapeutic antisera used in Argentina for Bothrops snakebite , the Bothrops moojeni venom is not used as immunogen , since this snake is not considered a serious public health problem .',
  'Snakebite envenomation is a serious public health concern in rural areas of Uganda .',
  'While in some countries of origin the high incidence of envenomations by dangerous arachnids can result in a serious problem to the health system , we assessed the risk that the same species pose when kept as pets under controlled maintenance conditions as significantly lower .',
  'Snakebites are a serious health problem in tropical countries .',
  'Snakebites constitute a serious public health problem in Central and South America , where species of the lancehead pit vipers ( genus Bothrops ) cause the majority of accidents .',
  'Snakebite is a serious medical problem in',
  "Snakebite is a severe medical , social , and economic problem in many parts of the world , chiefly in tropical and subtropical nations where majority of the world 's dangerous snakes are found and where access to treatment is limited .",
  'Snakebite envenoming is a serious problem in Myanmar .',
  'Snakebite envenoming is a serious global public health problem , and international initiatives , under the coordination of the World Health Organization and its regional offices , are being developed to reduce the impact of this neglected tropical disease .',
  'Envenomations constitute a serious public health problem in many developing countries .',
  'Envenomings by elapid snakes of the genus Dendroaspis , collectively known as mambas , represent a serious medical problem in sub-Saharan Africa .'],
 'snake': ['Snakebites are a serious worldwide public health problem .',
  'Accidents involving snakebites constitute a serious public health problem in many regions around the world .',
  'Snakebite envenomation is a serious medical problem in many developing tropical and subtropical countries .',
  'Snakebites are a serious public health problem and , in the Amazon , the',
  'In North Cameroon , venom inoculations by Echis Carinatus are frequent and severe and thus pose a serious problem at Public Health Services .',
  'Snake bites represent a serious public health problem , particularly in rural areas worldwide .',
  'Intoxication of the population of Guinea due to venomous snake bites ( 100 - 150 intoxications per 100,000 with an 18 % mortality rate ) is a serious public health problem in the Republic of Guinea .',
  'Although venomous snakebites are not a serious world wide problem from the epidemiological point of view and are rare under our conditions , it is frequently a very serious and life threatening matter .',
  'Envenomation from bite of exotic snakes is rare in France and represent a serious therapeutic problem : only an adapted antivenom is effective and obtaining such a treatment is a real difficulty .',
  'However , despite these efforts a lone snakebite diagnostic kit is available until now which is a severe concern for efficacious snakebite therapy .',
  'Snakebite is a severe problem in many parts of the world , specifically in tropical and subtropical regions .',
  'Snakebites is a neglected disease and in Brazil is considered a serious health problem , with the majority of the snakebites caused by the genus Bothrops .',
  'Snakebite envenomation is a serious medical problem in many tropical developing countries and was considered by WHO as a neglected tropical disease .',
  'Hemiscorpius lepturus envenomation is recognized as a serious health concern in tropical regions .',
  'A snakebite is a serious and important problem in tropical and subtropical cities .',
  'Snakebite is a serious medical and socio-economic problem affecting the healthy individuals and agricultural and farming populations worldwide .',
  'Uncertainty as to the species diagnosis remains a serious problem in the management of snake venom poisoning .',
  'Snakebite envenoming is a serious public health problem in Central America , where approximately 5,500 cases occur every year .',
  'Snakebite is a serious medical and socio-economic problem affecting the rural and agricultural laborers of tropical and sub-tropical region across the world leading to high morbidity and mortality .',
  'Systemic envenomation represents a serious medical problem with antivenom , which is raised against Acanthophis antarcticus venom , representing the primary treatment .',
  'Snakebite envenoming is a serious and life-threatening but neglected problem in the tropics .',
  'Although low case fatality and mortality rates were observed , much can still be done to prevent snakebites as they continue to be a serious public health problem considering the severity and potentially high economic impact for the individual and to society .',
  'Snakebite is a serious problem in rural India where several highly venomous species are commonly found in and around agricultural areas where prey such as rodents and amphibians are abundant .',
  'Myonecrosis is a serious result of rattlesnake bite and constitutes a persistent clinical problem .',
  'Snakebites are a serious medical , social , and economic problem that are experienced worldwide ; however , they are most serious in tropical and subtropical countries .',
  'Mortality due to snake envenomation is not a major problem in the United States with approximately 8 - 12 deaths per year , but envenomation is a serious problem that can result in functional disability , loss of extremities , and a costly recovery .',
  'Mortality due to snakebite is a serious public health problem , and available therapeutics are known to induce debilitating side effects .',
  'Snakebites are a serious public health problem due their high morbi-mortality .',
  'Snakebites represent a serious global public health problem , especially in tropical countries .',
  'Snakebite envenoming is a serious medical problem in different areas of the world .',
  'Morbidity and mortality due to envenoming by the carpet viper ( Echis ocellatus ) in northern Nigeria remains unacceptably high and constitutes a severe economic and public health problem to the local farming community in particular .',
  'Snakebites are a serious problem in public health due to their high morbimortality .',
  'Snakebite envenomings constitute a serious and neglected public health problem .',
  'Traditional medicine is an invaluable source of research into new medicines as a supplement for the treatment of snakebite , considered as a serious public health problem worldwide .',
  'Thirty-one consecutive cases of snake bite were studied in the Benue Valley , Nigeria where carpet viper ( Echis carinatus ) bite constitutes a serious health problem .',
  'Trimeresurus bite is a serious medical problem in Asia .',
  'Brown recluse spider bites are a serious medical problem in the southeastern United States .',
  'Snake bites represent a serious public health problem in many areas of the world .',
  'Injuries caused by venomous animals affect vast areas of Latin America , Southern Asia , Southeast Asia , sub-Saharan Africa , and Oceania , and pose a serious problem for global public health .',
  'In the production of current therapeutic antisera used in Argentina for Bothrops snakebite , the Bothrops moojeni venom is not used as immunogen , since this snake is not considered a serious public health problem .',
  'Snakebite envenomation is a serious public health concern in rural areas of Uganda .',
  'While in some countries of origin the high incidence of envenomations by dangerous arachnids can result in a serious problem to the health system , we assessed the risk that the same species pose when kept as pets under controlled maintenance conditions as significantly lower .',
  'Snakebites are a serious health problem in tropical countries .',
  'Snakebites constitute a serious public health problem in Central and South America , where species of the lancehead pit vipers ( genus Bothrops ) cause the majority of accidents .',
  'Snakebite is a serious medical problem in',
  "Snakebite is a severe medical , social , and economic problem in many parts of the world , chiefly in tropical and subtropical nations where majority of the world 's dangerous snakes are found and where access to treatment is limited .",
  'Snakebite envenoming is a serious problem in Myanmar .',
  'Snakebite envenoming is a serious global public health problem , and international initiatives , under the coordination of the World Health Organization and its regional offices , are being developed to reduce the impact of this neglected tropical disease .',
  'Envenomations constitute a serious public health problem in many developing countries .',
  'Envenomings by elapid snakes of the genus Dendroaspis , collectively known as mambas , represent a serious medical problem in sub-Saharan Africa .'],
 'envenomation': ['Snakebites are a serious worldwide public health problem .',
  'Accidents involving snakebites constitute a serious public health problem in many regions around the world .',
  'Snakebite envenomation is a serious medical problem in many developing tropical and subtropical countries .',
  'Snakebites are a serious public health problem and , in the Amazon , the',
  'In North Cameroon , venom inoculations by Echis Carinatus are frequent and severe and thus pose a serious problem at Public Health Services .',
  'Snake bites represent a serious public health problem , particularly in rural areas worldwide .',
  'Intoxication of the population of Guinea due to venomous snake bites ( 100 - 150 intoxications per 100,000 with an 18 % mortality rate ) is a serious public health problem in the Republic of Guinea .',
  'Although venomous snakebites are not a serious world wide problem from the epidemiological point of view and are rare under our conditions , it is frequently a very serious and life threatening matter .',
  'Envenomation from bite of exotic snakes is rare in France and represent a serious therapeutic problem : only an adapted antivenom is effective and obtaining such a treatment is a real difficulty .',
  'However , despite these efforts a lone snakebite diagnostic kit is available until now which is a severe concern for efficacious snakebite therapy .',
  'Snakebite is a severe problem in many parts of the world , specifically in tropical and subtropical regions .',
  'Snakebites is a neglected disease and in Brazil is considered a serious health problem , with the majority of the snakebites caused by the genus Bothrops .',
  'Snakebite envenomation is a serious medical problem in many tropical developing countries and was considered by WHO as a neglected tropical disease .',
  'Hemiscorpius lepturus envenomation is recognized as a serious health concern in tropical regions .',
  'A snakebite is a serious and important problem in tropical and subtropical cities .',
  'Snakebite is a serious medical and socio-economic problem affecting the healthy individuals and agricultural and farming populations worldwide .',
  'Uncertainty as to the species diagnosis remains a serious problem in the management of snake venom poisoning .',
  'Snakebite envenoming is a serious public health problem in Central America , where approximately 5,500 cases occur every year .',
  'Snakebite is a serious medical and socio-economic problem affecting the rural and agricultural laborers of tropical and sub-tropical region across the world leading to high morbidity and mortality .',
  'Systemic envenomation represents a serious medical problem with antivenom , which is raised against Acanthophis antarcticus venom , representing the primary treatment .',
  'Snakebite envenoming is a serious and life-threatening but neglected problem in the tropics .',
  'Although low case fatality and mortality rates were observed , much can still be done to prevent snakebites as they continue to be a serious public health problem considering the severity and potentially high economic impact for the individual and to society .',
  'Snakebite is a serious problem in rural India where several highly venomous species are commonly found in and around agricultural areas where prey such as rodents and amphibians are abundant .',
  'Myonecrosis is a serious result of rattlesnake bite and constitutes a persistent clinical problem .',
  'Snakebites are a serious medical , social , and economic problem that are experienced worldwide ; however , they are most serious in tropical and subtropical countries .',
  'Mortality due to snake envenomation is not a major problem in the United States with approximately 8 - 12 deaths per year , but envenomation is a serious problem that can result in functional disability , loss of extremities , and a costly recovery .',
  'Mortality due to snakebite is a serious public health problem , and available therapeutics are known to induce debilitating side effects .',
  'Snakebites are a serious public health problem due their high morbi-mortality .',
  'Snakebites represent a serious global public health problem , especially in tropical countries .',
  'Snakebite envenoming is a serious medical problem in different areas of the world .',
  'Morbidity and mortality due to envenoming by the carpet viper ( Echis ocellatus ) in northern Nigeria remains unacceptably high and constitutes a severe economic and public health problem to the local farming community in particular .',
  'Snakebites are a serious problem in public health due to their high morbimortality .',
  'Snakebite envenomings constitute a serious and neglected public health problem .',
  'Traditional medicine is an invaluable source of research into new medicines as a supplement for the treatment of snakebite , considered as a serious public health problem worldwide .',
  'Thirty-one consecutive cases of snake bite were studied in the Benue Valley , Nigeria where carpet viper ( Echis carinatus ) bite constitutes a serious health problem .',
  'Trimeresurus bite is a serious medical problem in Asia .',
  'Brown recluse spider bites are a serious medical problem in the southeastern United States .',
  'Snake bites represent a serious public health problem in many areas of the world .',
  'Injuries caused by venomous animals affect vast areas of Latin America , Southern Asia , Southeast Asia , sub-Saharan Africa , and Oceania , and pose a serious problem for global public health .',
  'In the production of current therapeutic antisera used in Argentina for Bothrops snakebite , the Bothrops moojeni venom is not used as immunogen , since this snake is not considered a serious public health problem .',
  'Snakebite envenomation is a serious public health concern in rural areas of Uganda .',
  'While in some countries of origin the high incidence of envenomations by dangerous arachnids can result in a serious problem to the health system , we assessed the risk that the same species pose when kept as pets under controlled maintenance conditions as significantly lower .',
  'Snakebites are a serious health problem in tropical countries .',
  'Snakebites constitute a serious public health problem in Central and South America , where species of the lancehead pit vipers ( genus Bothrops ) cause the majority of accidents .',
  'Snakebite is a serious medical problem in',
  "Snakebite is a severe medical , social , and economic problem in many parts of the world , chiefly in tropical and subtropical nations where majority of the world 's dangerous snakes are found and where access to treatment is limited .",
  'Snakebite envenoming is a serious problem in Myanmar .',
  'Snakebite envenoming is a serious global public health problem , and international initiatives , under the coordination of the World Health Organization and its regional offices , are being developed to reduce the impact of this neglected tropical disease .',
  'Envenomations constitute a serious public health problem in many developing countries .',
  'Envenomings by elapid snakes of the genus Dendroaspis , collectively known as mambas , represent a serious medical problem in sub-Saharan Africa .'],
 'soil': ['The quality of agricultural soil is vital to human health , however soil contamination is a severe problem in China .',
  'Cadmium ( Cd ) pollution is a serious global problem , which causes irreversible toxic effects on animals .',
  'Soil erosion is a serious environmental problem in Guizhou Province , which is located in the centre of the karst areas of southwestern China .',
  'Although acute or chronic effects of the chemical contamination of shellfish have not been clearly documented , the cadmium pollution of some shellfish harvesting waters raises a serious problem .',
  'Heavy metal pollution in soils amended with biosolids has been a serious problem worldwide for clean food production .',
  'Rangeland degradation has been identified as a serious concern in alpine regions of western China on the Qinghai-Tibetan plateau ( QTP ) .',
  'Contamination of long-term sewage effluent irrigated soils by potentially toxic elements ( PTEs ) is a serious concern due to its high environmental and health risk .',
  'Accumulation of cadmium ( Cd ) shows a serious problem for the environment and poses a threat to plants .',
  'For this reason , soil metal pollution has become a severe problem in many parts of the world .',
  'As more issues have arisen in China due to rice contaminated by cadmium ( Cd ) , Cd contamination in arable soils has become a severe problem .',
  'Cd pollution in farmland is becoming a serious problem because it affects the safety of rice production and human health .',
  'Soil degradation through erosion and desertification reduces soil productivity , and is a serious problem in agricultural production of China .',
  'Soil contamination by heavy metals is a serious concern due to their toxicity and ability to accumulate in the environment .',
  'As soil cadmium ( Cd ) contamination becomes a serious concern and one of the significant environmental pollution issues all over the world , knowledge of the basic chemistry , origin , inputs , sources , quantity , chemical forms , reactions , as well as the fate and transport of Cd in different types of soil is crucial for better understanding Cd bioavailability , health risks and remedial options .',
  'High salinity soils inhibit crop production worldwide and represent a serious agricultural problem .',
  'Soil contamination by heavy metals and metalloids is a serious problem which needs to be addressed .',
  'Soil compaction is a serious global problem , and is a major cause of inadequate rooting and poor yield in crops around the world .',
  'Metal pollution in urban soils due to smelting and electroplating has become a severe problem in China .',
  'Pesticides and heavy metals pollution in soil environment has become a serious problem in many countries including China .',
  'Land degradation by water and wind erosion is a serious problem worldwide .',
  'Accumulation of Cd in rice grain is a serious concern of food safety since rice as a staple food is a major source of Cd intake in Asian countries .',
  'Increased salinity in rivers and streams is a serious environmental concern , and in Australia there is growing information about the acute tolerances to salinity for freshwater macroinvertebrates , but much less information about chronic and sub-lethal tolerances .',
  'Recently , soil contamination by heavy metals in farmland has become a severe problem .',
  'Higher pH decreases the t 1/2 of Cd in soil solution , indicating that higher pH ( alkaline ) is not a serious concern in Cd toxicity than lower pH ( acidic ) .',
  'Industrial pollutants such as heavy metals and hydrocarbons in soils represent a serious concern due to their persistence and negative effects on the environment , affecting cellular processes in living organisms and even causing mutations and cancer .',
  "Cadmium ( Cd ) exposure poses a serious environmental problem due to the metal 's bioaccumulation and difficult to eliminate from body .",
  'Soil contamination with toxic heavy metals [ such as cadmium ( Cd ) ] is becoming a serious global problem due to rapid development of social economy .',
  'Both cadmium ( Cd ) contamination in agricultural soils and drought stress pose a serious problem for crop quality and human health .',
  'The contamination of large areas of arable land with cadmium ( Cd ) is a serious concern worldwide and environmentally feasible amendments are necessary to minimize Cd accumulation in cereals such as rice ( Oryza sativa L. ) .',
  'Road embankments erosion is a serious problem in Spain .',
  'Contamination of heavy metals ( HMs ) in agricultural soil has become a serious environmental problem because it poses a serious threat to human health by entering into food chains .',
  'Soil salinization induced by the dual effects of natural environment and human activities is a serious ecological problem globally .',
  'Polluted agricultural soils are a serious problem for food safety , with phytoremediation being the most favorable alternative from the environmental perspective .',
  'Cadmium nephrotoxicity is a serious environmental health problem as it will eventually end up with end stage renal disease .',
  'Contamination of agricultural soil with heavy metals has become a serious concern worldwide .',
  'Soil heavy metal contamination is a serious environmental problem needed to be addressed due to the toxicities of metals to both humans and living organisms .',
  'The contamination of soil by Li is becoming a serious problem , which might be a threat for crop production in the near future .',
  'Contamination of soils with cadmium ( Cd ) is a serious problem worldwide .',
  'Trace metals ( TM ) contamination is a severe problem in the environment and produced an adverse effect on the productivity of crops .',
  "Heavy metal polluted soils have been a serious problem for the global ecological balance and people 's health .",
  'Cadmium ( Cd ) contaminated in rice grains is a serious problem because most Asians consume rice on a daily basis .',
  'Heavy metal contamination in agricultural soils has become a serious environmental concern due to their generally high mobility and toxic effects on plants and food security .',
  'The pollution of agricultural soils with cadmium ( Cd ) has become a serious problem worldwide .',
  'Soil erosion has become a serious problem in recent decades due to unhalted trends of unsustainable land use practices .',
  'Soil erosion is a severe problem for many developing regions that lack adequate infrastructure to combat the problem .',
  'Soil erosion has become a serious ecological problem in many catchments .',
  'Erosion of denuded steep rocky slopes causes increasing losses of nitrogen and phosphorus , which is a severe problem in rocky slope protection .',
  'Development and land use change lead to accelerated soil erosion as a serious environmental problem in river catchments in Iran .',
  'Soil contamination by heavy metals is becoming a serious environmental problem especially in saline and sodic soils and information on different fractions of metals is useful to predict their mobility and availability in soil .',
  'Such erosion has become a serious problem in China .',
  'Metal pollution in soil is a serious problem among waste landfill sites and associated environment all over the globe .',
  'Cadmium ( Cd ) stress is a serious concern in agricultural soils worldwide , and increasing accumulation and subsequent transfer to humans via the food chain can have potentially harmful effects .',
  'Cadmium pollution has become a serious environmental problem .',
  'Cadmium (Cd)-contaminated rice is a serious health concern .',
  'Combined stress of salinity and heavy metal is a serious problem for crop production ; however , physiological mechanisms of tolerance to such condition remain elusive in cotton .',
  'Soil contamination with Cd from P fertilizer and other anthropogenic and geogenic sources is a serious problem .',
  'Soil contamination by heavy metals is a serious global environmental problem , especially for developing countries .',
  'Contamination of cadmium ( Cd ) in paddy soil is a serious environmental problem threatening food safety in some parts of southern China , where rice grain Cd concentration often exceeds the Chinese limit ( 0.2 \u202f mg \u202f kg',
  'A serious problem with this is the severe soil contamination that resulted from intensive mining and metallurgical activities that has taken place in the greater area for the past 3,000 years .',
  'Agricultural soil pollution by heavy metals is a severe global ecological problem .',
  'Soil pollution with heavy metal is a serious problem across the globe and is on the rise due to the current intensification of chemical industry .',
  'The risk of the desertification of a part of Romania is increasingly evident , constituting a serious problem for the environment and the society .',
  'In many parts of the world , soil acidification and heavy metal contamination has become a serious concern due to the adverse effects on chemical properties of soil and crop yield .',
  'Wind erosion is a primary cause of desertification as well as being a serious ecological problem in arid and semi-arid areas across the world .',
  'Gully erosion is a serious environmental problem worldwide , causing soil loss , land degradation , silting up of reservoirs and even catastrophic flooding .',
  'Gully erosion is considered as a severe environmental problem in many areas of the world which causes huge damages to agricultural lands and infrastructures ( i.e. roads , buildings , and bridges ) ; however , gully erosion modeling and prediction with high accuracy are still difficult due to the complex interactions of various factors .',
  'Soil salinization is a serious and growing problem around the world .',
  'Soil contamination with heavy metals has become a serious environmental problem that requires affordable strategies of remediation .',
  'The accumulation of heavy metals in agricultural soils is a serious environmental problem .',
  'Soil contaminated with heavy metals ( HMs ) is a serious problem throughout the world that threatens all living organisms in the soil .',
  'Contamination of soils with cadmium ( Cd ) is a serious problem worldwide .',
  'Soil Cd pollution resulting from human activities has become a serious food safety concern .',
  'Cadmium ( Cd ) contamination in red soil has become a serious environmental concern due to its toxic effects on organisms and the food chain .',
  'Soil heavy metal contamination is a serious environmental problem .',
  'Soil erosion and both its on-site and off-site impacts are increasingly seen as a serious environmental problem across the world .',
  'The contamination of soil with heavy metals is a severe problem due to adverse impact of heavy metals on environmental safety and human health .',
  'The proposed methodology is demonstrated for an example at the Upper Colorado River Basin ( UCRB ) , where salinity is a serious concern .',
  'Soil heavy metal ( HM ) contamination has posed a serious problem for safe food production .',
  'Soil water erosion is a serious problem , especially in agricultural lands .',
  'Land degradation is a serious problem in tropical mountainous areas .',
  'Soil erosion caused by wind is a serious environmental problem that results in land degradation and threatens sustainable development .',
  'In recent years , toxic pollution from heavy metal(loid)s in soil has become a severe environmental problem worldwide .',
  'Soil salinization is a serious problem that affects the seedling growth in many regions .',
  'Soil heavy metals pollution is a serious problem worldwide due to its potential human health risks through food chain .',
  'Soil cadmium ( Cd ) contamination in China has become a serious concern due to its high toxicity to human health through food chains .',
  'Soil desertification has become a serious problem that endangered sustainable development in the ecotone .',
  'Soil salinity is a serious problem worldwide that reduces agricultural productivity .',
  "Cadmium poisoning poses a serious health concern due to cadmium 's increasing industrial use , yet there is currently no recommended treatment .",
  'Soil erosion is a serious environmental problem .',
  'Heavy metal ( HM ) pollution of farmland is a serious problem worldwide and consumption of HM-contaminated food products poses significant public health risks .',
  'Salinity is a serious environmental problem .',
  "Ubiquity of Cd makes it a serious environmental health problem that needs to be thoroughly assessed because it already affects or will affect large proportions of the world 's population .",
  'Agricultural soils contamination with cadmium ( Cd ) has become a serious concern through anthropogenic activities .',
  'Cadmium ( Cd ) contamination poses a serious problem in paddy soils .',
  'Soil contamination by heavy metals has become a serious problem mainly because , above certain concentrations , all metals have adverse effects on human health .',
  'Soil cadmium ( Cd ) contamination has become a serious problem in China .',
  'Soil contamination by heavy metals constitutes a serious global environmental problem , and numerous remediation technologies have been developed .',
  'Soil heavy metal pollution due to long-term sewage irrigation is a serious environmental problem in many irrigation areas in northern China .',
  'Copper and cadmium in soil is a severe soil pollution problem in China .',
  'Cadmium ( Cd ) pollution is a serious environmental problem .',
  'Overgrazing is a severe problem in several regions in Northwestern China and has caused serious land degradation .',
  'Salinity represents a serious problem in the Mediterranean region .',
  'Heavy metal pollution is a serious environmental problem in agricultural soils since the uptake of heavy metals by plants represents an entry point into the food chain and is influenced by the form and amount of nitrogen ( N ) fertilization .',
  'The accumulation of heavy metal in the soil is a serious concern for sustainable food production due to their toxic effects on plants and other living things .',
  'Soil erosion is a serious problem in areas with expanding construction , agricultural production , and improper storm water management .',
  'Heavy metal contamination of agricultural soil has become a serious global problem .',
  'Cadmium ( Cd ) contamination is a serious food safety problem .',
  'Cadmium ( Cd ) pollution is a serious widespread environmental problem that not only destroys the microbial ecology of soil and decreases crop production , but also poses a serious risk to human health .',
  'Soil contamination by cadmium ( Cd ) poses a serious environmental and public health concern .',
  'Soil salinity accumulation is strong in arid areas and it has become a serious environmental problem .',
  'Cadmium contamination is a serious environmental problem for modern agriculture and human health .',
  'Food chain contamination by cadmium ( Cd ) is globally a serious health concern resulting in chronic abnormalities .',
  'Heavy metals contamination of soil especially with cadmium ( Cd ) is a serious environmental concern in the current industrial era .',
  'Soil cadmium ( Cd ) contamination has posed a serious problem for safe food production and become a potential agricultural and environmental hazard worldwide .',
  'Since A. donax is a high-yield biomass crop , reduction of biomass might be a serious agronomical problem in saline conditions .',
  'Cadmium ( Cd ) , which is a deadly heavy metal of work-related and environmental concern , has been recognized as a substance that is teratogenic and carcinogenic for humans .',
  'A rise in [Ca2+]i may be a serious problem for plants in microgravity environment .',
  'Soil salinization is a serious problem for cultivation of rice , as among cereals rice is the most salt sensitive crop , and more than 40 % of the total agricultural land amounting to approximately 80 million ha the world over is salt affected .',
  'Cadmium is a toxic and carcinogenic heavy metal that nowadays constitutes a serious environmental health problem .',
  'Ground subsidence is not a severe problem at Wairakei but may prove to be one at the nearby Broadlands field .',
  'Contamination of arid and semi-arid ecosystems by toxic heavy metals is a serious concern due to its impact on growth and productivity of crop and health risk through food chain .',
  'Salinity is one of the most widespread agricultural problems in arid and semi-arid regions that makes fields unproductive , and soil salinization is a serious problem in the entire world .',
  'Heavy metals contaminated soil is a serious environmental concern that has a negative impact on agriculture and ecosystem .',
  'Water-induced erosion of iron tailings is a serious problem affecting ecological restoration , but , little is known about how the occurrence of erosion on tailings slopes and types of reclaimed substrates that are beneficial to reducing slope erosion .',
  'Due to the utilization of landfill technology and geothermal energy production in Tibet , the contamination of the soils and underground water by trace element has currently become a serious problem , both ecologically and to the human health point of view .',
  'Heavy metal contamination in croplands has been a serious concern because of its high health risk through soil-food chain transfer .',
  'Soil contamination by heavy metals is a serious problem to humans due to its high level of toxicity .',
  'Cadmium ( Cd ) contamination in soils has become a serious and widespread environmental problem , especially in areas with high natural background Cd values , but the mechanism of Cd enrichment in these areas is still unclear .',
  'Cadmium ( Cd ) pollution in soil is a serious problem affecting environmental safety and human health , and the majority of Cd in human body comes from edible vegetables , especially leafy vegetables .',
  'Rapid urbanization and industrial growth have triggered heavy metal contamination in agricultural soil in Dhaka , which is a serious concern for ecological risk and public health issues .',
  'Salt stress has become a severe global problem , and salinity is one of the most important abiotic factors limiting plant growth and yield .',
  'Due to the fragility of the natural environment and overexploitation of land by the local people , desertification is becoming a serious problem in the valleys .',
  'The increasing heavy metal contamination in agricultural soils has become a serious concern across the globe .',
  'Cadmium contamination of agricultural soils is a serious problem due to its toxic effects on health and yield of crop plants .',
  'Rocky desertification induced by soil loss is a serious ecological problem in karst mountain areas .'],
 'soils': ['The quality of agricultural soil is vital to human health , however soil contamination is a severe problem in China .',
  'Cadmium ( Cd ) pollution is a serious global problem , which causes irreversible toxic effects on animals .',
  'Although acute or chronic effects of the chemical contamination of shellfish have not been clearly documented , the cadmium pollution of some shellfish harvesting waters raises a serious problem .',
  'Heavy metal pollution in soils amended with biosolids has been a serious problem worldwide for clean food production .',
  'Contamination of long-term sewage effluent irrigated soils by potentially toxic elements ( PTEs ) is a serious concern due to its high environmental and health risk .',
  'Accumulation of cadmium ( Cd ) shows a serious problem for the environment and poses a threat to plants .',
  'For this reason , soil metal pollution has become a severe problem in many parts of the world .',
  'As more issues have arisen in China due to rice contaminated by cadmium ( Cd ) , Cd contamination in arable soils has become a severe problem .',
  'Cd pollution in farmland is becoming a serious problem because it affects the safety of rice production and human health .',
  'Soil contamination by heavy metals is a serious concern due to their toxicity and ability to accumulate in the environment .',
  'As soil cadmium ( Cd ) contamination becomes a serious concern and one of the significant environmental pollution issues all over the world , knowledge of the basic chemistry , origin , inputs , sources , quantity , chemical forms , reactions , as well as the fate and transport of Cd in different types of soil is crucial for better understanding Cd bioavailability , health risks and remedial options .',
  'Soil contamination by heavy metals and metalloids is a serious problem which needs to be addressed .',
  'Metal pollution in urban soils due to smelting and electroplating has become a severe problem in China .',
  'Pesticides and heavy metals pollution in soil environment has become a serious problem in many countries including China .',
  'Accumulation of Cd in rice grain is a serious concern of food safety since rice as a staple food is a major source of Cd intake in Asian countries .',
  'Recently , soil contamination by heavy metals in farmland has become a severe problem .',
  'Higher pH decreases the t 1/2 of Cd in soil solution , indicating that higher pH ( alkaline ) is not a serious concern in Cd toxicity than lower pH ( acidic ) .',
  'Industrial pollutants such as heavy metals and hydrocarbons in soils represent a serious concern due to their persistence and negative effects on the environment , affecting cellular processes in living organisms and even causing mutations and cancer .',
  "Cadmium ( Cd ) exposure poses a serious environmental problem due to the metal 's bioaccumulation and difficult to eliminate from body .",
  'Soil contamination with toxic heavy metals [ such as cadmium ( Cd ) ] is becoming a serious global problem due to rapid development of social economy .',
  'Both cadmium ( Cd ) contamination in agricultural soils and drought stress pose a serious problem for crop quality and human health .',
  'The contamination of large areas of arable land with cadmium ( Cd ) is a serious concern worldwide and environmentally feasible amendments are necessary to minimize Cd accumulation in cereals such as rice ( Oryza sativa L. ) .',
  'Contamination of heavy metals ( HMs ) in agricultural soil has become a serious environmental problem because it poses a serious threat to human health by entering into food chains .',
  'Polluted agricultural soils are a serious problem for food safety , with phytoremediation being the most favorable alternative from the environmental perspective .',
  'Cadmium nephrotoxicity is a serious environmental health problem as it will eventually end up with end stage renal disease .',
  'Contamination of agricultural soil with heavy metals has become a serious concern worldwide .',
  'Soil heavy metal contamination is a serious environmental problem needed to be addressed due to the toxicities of metals to both humans and living organisms .',
  'The contamination of soil by Li is becoming a serious problem , which might be a threat for crop production in the near future .',
  'Contamination of soils with cadmium ( Cd ) is a serious problem worldwide .',
  'Trace metals ( TM ) contamination is a severe problem in the environment and produced an adverse effect on the productivity of crops .',
  "Heavy metal polluted soils have been a serious problem for the global ecological balance and people 's health .",
  'Cadmium ( Cd ) contaminated in rice grains is a serious problem because most Asians consume rice on a daily basis .',
  'Heavy metal contamination in agricultural soils has become a serious environmental concern due to their generally high mobility and toxic effects on plants and food security .',
  'The pollution of agricultural soils with cadmium ( Cd ) has become a serious problem worldwide .',
  'Soil contamination by heavy metals is becoming a serious environmental problem especially in saline and sodic soils and information on different fractions of metals is useful to predict their mobility and availability in soil .',
  'Metal pollution in soil is a serious problem among waste landfill sites and associated environment all over the globe .',
  'Cadmium ( Cd ) stress is a serious concern in agricultural soils worldwide , and increasing accumulation and subsequent transfer to humans via the food chain can have potentially harmful effects .',
  'Cadmium pollution has become a serious environmental problem .',
  'Cadmium (Cd)-contaminated rice is a serious health concern .',
  'Soil contamination with Cd from P fertilizer and other anthropogenic and geogenic sources is a serious problem .',
  'Soil contamination by heavy metals is a serious global environmental problem , especially for developing countries .',
  'Contamination of cadmium ( Cd ) in paddy soil is a serious environmental problem threatening food safety in some parts of southern China , where rice grain Cd concentration often exceeds the Chinese limit ( 0.2 \u202f mg \u202f kg',
  'A serious problem with this is the severe soil contamination that resulted from intensive mining and metallurgical activities that has taken place in the greater area for the past 3,000 years .',
  'Agricultural soil pollution by heavy metals is a severe global ecological problem .',
  'Soil pollution with heavy metal is a serious problem across the globe and is on the rise due to the current intensification of chemical industry .',
  'In many parts of the world , soil acidification and heavy metal contamination has become a serious concern due to the adverse effects on chemical properties of soil and crop yield .',
  'Soil contamination with heavy metals has become a serious environmental problem that requires affordable strategies of remediation .',
  'The accumulation of heavy metals in agricultural soils is a serious environmental problem .',
  'Soil contaminated with heavy metals ( HMs ) is a serious problem throughout the world that threatens all living organisms in the soil .',
  'Contamination of soils with cadmium ( Cd ) is a serious problem worldwide .',
  'Soil Cd pollution resulting from human activities has become a serious food safety concern .',
  'Cadmium ( Cd ) contamination in red soil has become a serious environmental concern due to its toxic effects on organisms and the food chain .',
  'Soil heavy metal contamination is a serious environmental problem .',
  'The contamination of soil with heavy metals is a severe problem due to adverse impact of heavy metals on environmental safety and human health .',
  'Soil heavy metal ( HM ) contamination has posed a serious problem for safe food production .',
  'In recent years , toxic pollution from heavy metal(loid)s in soil has become a severe environmental problem worldwide .',
  'Soil heavy metals pollution is a serious problem worldwide due to its potential human health risks through food chain .',
  'Soil cadmium ( Cd ) contamination in China has become a serious concern due to its high toxicity to human health through food chains .',
  "Cadmium poisoning poses a serious health concern due to cadmium 's increasing industrial use , yet there is currently no recommended treatment .",
  'Heavy metal ( HM ) pollution of farmland is a serious problem worldwide and consumption of HM-contaminated food products poses significant public health risks .',
  "Ubiquity of Cd makes it a serious environmental health problem that needs to be thoroughly assessed because it already affects or will affect large proportions of the world 's population .",
  'Agricultural soils contamination with cadmium ( Cd ) has become a serious concern through anthropogenic activities .',
  'Cadmium ( Cd ) contamination poses a serious problem in paddy soils .',
  'Soil contamination by heavy metals has become a serious problem mainly because , above certain concentrations , all metals have adverse effects on human health .',
  'Soil cadmium ( Cd ) contamination has become a serious problem in China .',
  'Soil contamination by heavy metals constitutes a serious global environmental problem , and numerous remediation technologies have been developed .',
  'Soil heavy metal pollution due to long-term sewage irrigation is a serious environmental problem in many irrigation areas in northern China .',
  'Copper and cadmium in soil is a severe soil pollution problem in China .',
  'Cadmium ( Cd ) pollution is a serious environmental problem .',
  'Heavy metal pollution is a serious environmental problem in agricultural soils since the uptake of heavy metals by plants represents an entry point into the food chain and is influenced by the form and amount of nitrogen ( N ) fertilization .',
  'The accumulation of heavy metal in the soil is a serious concern for sustainable food production due to their toxic effects on plants and other living things .',
  'Heavy metal contamination of agricultural soil has become a serious global problem .',
  'Cadmium ( Cd ) contamination is a serious food safety problem .',
  'Cadmium ( Cd ) pollution is a serious widespread environmental problem that not only destroys the microbial ecology of soil and decreases crop production , but also poses a serious risk to human health .',
  'Soil contamination by cadmium ( Cd ) poses a serious environmental and public health concern .',
  'Cadmium contamination is a serious environmental problem for modern agriculture and human health .',
  'Food chain contamination by cadmium ( Cd ) is globally a serious health concern resulting in chronic abnormalities .',
  'Heavy metals contamination of soil especially with cadmium ( Cd ) is a serious environmental concern in the current industrial era .',
  'Soil cadmium ( Cd ) contamination has posed a serious problem for safe food production and become a potential agricultural and environmental hazard worldwide .',
  'Cadmium ( Cd ) , which is a deadly heavy metal of work-related and environmental concern , has been recognized as a substance that is teratogenic and carcinogenic for humans .',
  'Cadmium is a toxic and carcinogenic heavy metal that nowadays constitutes a serious environmental health problem .',
  'Contamination of arid and semi-arid ecosystems by toxic heavy metals is a serious concern due to its impact on growth and productivity of crop and health risk through food chain .',
  'Heavy metals contaminated soil is a serious environmental concern that has a negative impact on agriculture and ecosystem .',
  'Due to the utilization of landfill technology and geothermal energy production in Tibet , the contamination of the soils and underground water by trace element has currently become a serious problem , both ecologically and to the human health point of view .',
  'Heavy metal contamination in croplands has been a serious concern because of its high health risk through soil-food chain transfer .',
  'Soil contamination by heavy metals is a serious problem to humans due to its high level of toxicity .',
  'Cadmium ( Cd ) contamination in soils has become a serious and widespread environmental problem , especially in areas with high natural background Cd values , but the mechanism of Cd enrichment in these areas is still unclear .',
  'Cadmium ( Cd ) pollution in soil is a serious problem affecting environmental safety and human health , and the majority of Cd in human body comes from edible vegetables , especially leafy vegetables .',
  'Rapid urbanization and industrial growth have triggered heavy metal contamination in agricultural soil in Dhaka , which is a serious concern for ecological risk and public health issues .',
  'The increasing heavy metal contamination in agricultural soils has become a serious concern across the globe .',
  'Cadmium contamination of agricultural soils is a serious problem due to its toxic effects on health and yield of crop plants .'],
 'china': ['With the explosive economic development of China over the past few decades , air pollution has become a serious environmental problem and has attracted increasing global concern .',
  'Airborne pollution is a serious , and will be a major problem in Hong Kong within the next few years .',
  'Increasing ozone concentrations are becoming a severe problem for air pollution in China and have an adverse impact on human health .',
  'Air pollution is a serious environmental problem in China .',
  'Surface ozone is a severe air pollution problem in the North China Plain , which is home to 300 million people .',
  'Along with the rapid socioeconomic development , air pollution in China has become a severe problem .',
  'At the present time , ambient air pollution is a serious public health problem in China .',
  'In recent years , suspended particle pollution has become a serious problem in Taiwan .',
  'Ambient air pollution is becoming a serious environmental problem in China .',
  'The air pollution in China is a severe problem .',
  'Air pollution in China is a serious problem and an inevitable threat to human health .',
  'Urban air quality is becoming a serious public health concern in China .',
  'Air pollution has become a serious problem in Beijing , China .',
  'With dense population and rapid economic development of China , air pollution is still a serious problem and the prevalence of eczema has been elevating .',
  'Visibility degradation caused by air pollution has become a serious environmental problem in megacities in Northeast Asia .',
  "China 's lockdown to control COVID-19 brought significant declines in air pollutant emissions , but haze was still a serious problem in North China Plain ( NCP ) during late-January to mid-February of 2020 .",
  'Our results showed that due to the rapid urbanization and relocation of industrial plants from urban areas to rural areas in the past 20 years , air pollution in rural areas is becoming a serious problem in Shanghai and the Yangtze River delta .',
  'With rapid economic development , air pollution became a serious problem in China .',
  'With the unprecedented urbanization during the past three decades , air quality in many Chinese cities has been a serious issue which poses great challenges for urban sustainability .',
  'In China , regional haze pollution is a serious environmental problem .',
  'Nowadays , air pollution is a severe environmental problem in China .',
  'Haze is a serious pollution problem during the wintertime in North China .',
  'Air pollution is a serious environmental problem in China .',
  'Haze weather has become a serious environmental pollution problem which occurs in many Chinese cities .',
  'Air pollution is a severe public health problem in Taiwan .'],
 'haze': ['With the explosive economic development of China over the past few decades , air pollution has become a serious environmental problem and has attracted increasing global concern .',
  'Airborne pollution is a serious , and will be a major problem in Hong Kong within the next few years .',
  'Increasing ozone concentrations are becoming a severe problem for air pollution in China and have an adverse impact on human health .',
  'Air pollution is a serious environmental problem in China .',
  'Surface ozone is a severe air pollution problem in the North China Plain , which is home to 300 million people .',
  'Along with the rapid socioeconomic development , air pollution in China has become a severe problem .',
  'At the present time , ambient air pollution is a serious public health problem in China .',
  'In recent years , suspended particle pollution has become a serious problem in Taiwan .',
  'Ambient air pollution is becoming a serious environmental problem in China .',
  'The air pollution in China is a severe problem .',
  'Air pollution in China is a serious problem and an inevitable threat to human health .',
  'Urban air quality is becoming a serious public health concern in China .',
  'Air pollution has become a serious problem in Beijing , China .',
  'With dense population and rapid economic development of China , air pollution is still a serious problem and the prevalence of eczema has been elevating .',
  'Visibility degradation caused by air pollution has become a serious environmental problem in megacities in Northeast Asia .',
  "China 's lockdown to control COVID-19 brought significant declines in air pollutant emissions , but haze was still a serious problem in North China Plain ( NCP ) during late-January to mid-February of 2020 .",
  'Our results showed that due to the rapid urbanization and relocation of industrial plants from urban areas to rural areas in the past 20 years , air pollution in rural areas is becoming a serious problem in Shanghai and the Yangtze River delta .',
  'With rapid economic development , air pollution became a serious problem in China .',
  'With the unprecedented urbanization during the past three decades , air quality in many Chinese cities has been a serious issue which poses great challenges for urban sustainability .',
  'In China , regional haze pollution is a serious environmental problem .',
  'Nowadays , air pollution is a severe environmental problem in China .',
  'Haze is a serious pollution problem during the wintertime in North China .',
  'Air pollution is a serious environmental problem in China .',
  'Haze weather has become a serious environmental pollution problem which occurs in many Chinese cities .',
  'Air pollution is a severe public health problem in Taiwan .'],
 'mycobacterium': ['The emergence of new strains of Mycobacterium tuberculosis resistant to some or all current antituberculosis drugs is a serious and crescent problem .',
  'The startling increase in the occurrence of rifampicin ( Rif ) resistance in the clinical isolates of Mycobacterium tuberculosis worldwide is posing a serious concern to tuberculosis management .',
  'The selection and soaring spread of Mycobacterium tuberculosis multidrug-resistant ( MDR-TB ) and extensively drug-resistant strains ( XDR-TB ) is a severe public health problem .',
  'Mycobacterial disease remains a serious global health problem .',
  'Mycobacterial disease remains a serious international public health concern .',
  'The emergence of drug-resistant strains of Mycobacterium tuberculosis is a serious public health problem .',
  'Multidrug-resistant strains of Mycobacterium tuberculosis are a serious and continuing human health problem .',
  'Intrinsic multidrug resistance of the Mycobacterium avium-intracellulare complex presents a serious problem in the treatment of the diseases caused by these bacteria .',
  'The increasing rate of appearance of multidrug-resistant strains of Mycobacterium tuberculosis ( MDR-TB ) is a serious problem at the present time .',
  'Despite decades of research many aspects of the biology of Mycobacterium tuberculosis remain unclear and this is reflected in the antiquated tools available to treat and prevent tuberculosis and consequently this disease remains a serious public health problem .',
  'Multiple drug resistance ( MDR ) among Mycobacterium tuberculosis poses a serious therapeutic problem .',
  'Mycobacterium ulcerans causes chronic nectotizing ulcers of the skin and subcutaneous tissue and is a serious health problem in some tropical countries .',
  'The selection and soaring spread of Mycobacterium tuberculosis multidrug-resistant ( MDR-TB ) and extensively drug-resistant strains ( XDR-TB ) is a severe public health problem .',
  'Infection and transmission of multidrug-resistant Mycobacterium tuberculosis ( MDR-Mtb ) and extensively drug-resistant M. tuberculosis ( XDR-Mtb ) is a serious health problem .',
  'Drug-resistant Mycobacterium tuberculosis ( TB ) infection represents a serious and growing problem .',
  'Drug resistance has become a serious public health problem in mycobacterial infectious diseases .',
  'Infections caused by drug-resistant Mycobacterium tuberculosis strains represent a serious public health problem in recent years .',
  'Rapid and accurate diagnosis of mycobacteria is very important in the prevention and effective treatment of tuberculosis which is still a serious public health problem .',
  'The selection and spread of Mycobacterium tuberculosis multidrug-resistant ( MDR-TB ) and extensively drug-resistant strains ( XDR-TB ) is a severe public health problem .'],
 'mycobacterial': ['The emergence of new strains of Mycobacterium tuberculosis resistant to some or all current antituberculosis drugs is a serious and crescent problem .',
  'The startling increase in the occurrence of rifampicin ( Rif ) resistance in the clinical isolates of Mycobacterium tuberculosis worldwide is posing a serious concern to tuberculosis management .',
  'The selection and soaring spread of Mycobacterium tuberculosis multidrug-resistant ( MDR-TB ) and extensively drug-resistant strains ( XDR-TB ) is a severe public health problem .',
  'Mycobacterial disease remains a serious global health problem .',
  'Mycobacterial disease remains a serious international public health concern .',
  'The emergence of drug-resistant strains of Mycobacterium tuberculosis is a serious public health problem .',
  'Multidrug-resistant strains of Mycobacterium tuberculosis are a serious and continuing human health problem .',
  'Intrinsic multidrug resistance of the Mycobacterium avium-intracellulare complex presents a serious problem in the treatment of the diseases caused by these bacteria .',
  'The increasing rate of appearance of multidrug-resistant strains of Mycobacterium tuberculosis ( MDR-TB ) is a serious problem at the present time .',
  'Despite decades of research many aspects of the biology of Mycobacterium tuberculosis remain unclear and this is reflected in the antiquated tools available to treat and prevent tuberculosis and consequently this disease remains a serious public health problem .',
  'Multiple drug resistance ( MDR ) among Mycobacterium tuberculosis poses a serious therapeutic problem .',
  'Mycobacterium ulcerans causes chronic nectotizing ulcers of the skin and subcutaneous tissue and is a serious health problem in some tropical countries .',
  'The selection and soaring spread of Mycobacterium tuberculosis multidrug-resistant ( MDR-TB ) and extensively drug-resistant strains ( XDR-TB ) is a severe public health problem .',
  'Infection and transmission of multidrug-resistant Mycobacterium tuberculosis ( MDR-Mtb ) and extensively drug-resistant M. tuberculosis ( XDR-Mtb ) is a serious health problem .',
  'Drug-resistant Mycobacterium tuberculosis ( TB ) infection represents a serious and growing problem .',
  'Drug resistance has become a serious public health problem in mycobacterial infectious diseases .',
  'Infections caused by drug-resistant Mycobacterium tuberculosis strains represent a serious public health problem in recent years .',
  'Rapid and accurate diagnosis of mycobacteria is very important in the prevention and effective treatment of tuberculosis which is still a serious public health problem .',
  'The selection and spread of Mycobacterium tuberculosis multidrug-resistant ( MDR-TB ) and extensively drug-resistant strains ( XDR-TB ) is a severe public health problem .'],
 'strains': ['The emergence of new strains of Mycobacterium tuberculosis resistant to some or all current antituberculosis drugs is a serious and crescent problem .',
  'The startling increase in the occurrence of rifampicin ( Rif ) resistance in the clinical isolates of Mycobacterium tuberculosis worldwide is posing a serious concern to tuberculosis management .',
  'The selection and soaring spread of Mycobacterium tuberculosis multidrug-resistant ( MDR-TB ) and extensively drug-resistant strains ( XDR-TB ) is a severe public health problem .',
  'Mycobacterial disease remains a serious global health problem .',
  'Mycobacterial disease remains a serious international public health concern .',
  'The emergence of drug-resistant strains of Mycobacterium tuberculosis is a serious public health problem .',
  'Multidrug-resistant strains of Mycobacterium tuberculosis are a serious and continuing human health problem .',
  'Intrinsic multidrug resistance of the Mycobacterium avium-intracellulare complex presents a serious problem in the treatment of the diseases caused by these bacteria .',
  'The increasing rate of appearance of multidrug-resistant strains of Mycobacterium tuberculosis ( MDR-TB ) is a serious problem at the present time .',
  'Despite decades of research many aspects of the biology of Mycobacterium tuberculosis remain unclear and this is reflected in the antiquated tools available to treat and prevent tuberculosis and consequently this disease remains a serious public health problem .',
  'Multiple drug resistance ( MDR ) among Mycobacterium tuberculosis poses a serious therapeutic problem .',
  'Mycobacterium ulcerans causes chronic nectotizing ulcers of the skin and subcutaneous tissue and is a serious health problem in some tropical countries .',
  'The selection and soaring spread of Mycobacterium tuberculosis multidrug-resistant ( MDR-TB ) and extensively drug-resistant strains ( XDR-TB ) is a severe public health problem .',
  'Infection and transmission of multidrug-resistant Mycobacterium tuberculosis ( MDR-Mtb ) and extensively drug-resistant M. tuberculosis ( XDR-Mtb ) is a serious health problem .',
  'Drug-resistant Mycobacterium tuberculosis ( TB ) infection represents a serious and growing problem .',
  'Drug resistance has become a serious public health problem in mycobacterial infectious diseases .',
  'Infections caused by drug-resistant Mycobacterium tuberculosis strains represent a serious public health problem in recent years .',
  'Rapid and accurate diagnosis of mycobacteria is very important in the prevention and effective treatment of tuberculosis which is still a serious public health problem .',
  'The selection and spread of Mycobacterium tuberculosis multidrug-resistant ( MDR-TB ) and extensively drug-resistant strains ( XDR-TB ) is a severe public health problem .'],
 'venous': ['Pediatric hospital-acquired ( HA ) venous thromboembolism ( VTE ) is a vexing problem with improvement efforts hampered by lack of robust surveillance methods to establish accurate rates of HA-VTE .',
  'Venous thromboembolism ( VTE ) , which is characterized by pulmonary embolism and deep vein thrombosis , has become a serious public concern .',
  'Venous thromboembolism ( VTE ) and deep vein thrombophlebitis ( DVT ) is a serious problem with high mortality and morbidity rates .',
  'Venous thromboembolism ( VTE ) remains a serious problem , and treatments surrounding this potentially life-threatening disease continue to evolve .',
  'The thrombotic risk of spaceflight : has a serious problem been overlooked for more than half of a century ?',
  'Deep venous thrombosis and pulmonary embolism , together called venous thromboembolism , remain a serious national health problem .',
  'Deep-vein thrombosis ( DVT ) is a serious problem that affects millions of people annually .',
  'Most of the responding surgeons consider venous thromboembolism a serious health problem .',
  'The increasing detection of VTE among Indian population , lack of awareness , underestimation of the risk , and fear of bleeding complications after chemical prophylaxis have made deep vein thrombosis ( DVT ) a serious problem , hence a standard guideline for thromboprophylaxis after trauma is essential .',
  'Thrombus formation remains a serious problem in developing blood compatible materials .',
  'Post-deep vein thrombosis ( DVT ) venous insufficiency is a vexing problem despite effective anticoagulation , and is characterized by vein wall fibrosis .',
  'Venous thromboembolism ( VTE ) is a serious medical problem and is one of the most important preventable causes of mortality and morbidity in hospitalized patients .',
  'Deep vein thrombosis is a serious medical problem that may lead to pulmonary embolus .',
  'Cerebral venous and sinus thrombosis ( CVST ) is still considered a severe clinical problem that is difficult to diagnose and manage and is linked to a poor prognosis .',
  'Deep venous thrombosis ( DVT ) is a serious problem that can potentially lead to many complications including life-threatening pulmonary arterial thrombosis .',
  'In the United States ( U.S. ) , the high morbidity and mortality rates make VTE a serious health concern ( 1 - 2 ) .',
  'Thrombosis is a serious problem in the United States .',
  'Thrombosis is a serious problem , and often leads to irreversible vision loss .',
  'Venous thromboembolism is a serious health problem and a significant cause of morbidity and mortality .',
  'Travel-related thrombosis is a serious public health concern considering the large and increasing number of travellers .',
  'Deep vein thrombosis ( DVT ) and its devastating complication , pulmonary embolism , are a severe health problem with high mortality .',
  'Venous thromboembolism ( VTE ) , comprising deep vein thrombosis and pulmonary embolism , is a serious clinical and public health concern .',
  'Venous thromboembolism ( VTE ) and its manifestations , including deep vein thrombosis ( DVT ) and pulmonary embolism ( PE ) , pose a life-threatening health problem for thousands of people each year .',
  'Venous thromboembolism ( VTE ) is a serious health problem for which pharmacological prophylaxis has been proven to be effective .',
  'Deep Vein Thrombosis ( DVT ) is a life threatening condition and a serious concern among hospitalised patients , with death occurring in approximately 6 % of cases .',
  'Deep vein thrombosis is a severe health problem .',
  'Deep vein thrombosis ( DVT ) is a serious health problem that affects more than 2 million people annually in the United States .',
  'Inappropriate thromboprophylaxis is a serious problem in Iran .',
  'Venous thromboembolism ( VTE ) prophylaxis , despite evidence for its efficacy , is not reliably and consistently prescribed , and is currently a serious concern for patient safety .',
  'These data reveal that DVT is a serious health problem in Spain , with high morbidity and mortality .',
  'Venous thromboembolism ( VTE ) , which includes deep vein thrombosis ( DVT ) and pulmonary embolism ( PE ) , is a serious health and social care problem of the developed world , affecting 1 in 1000 adults every year , and with an annual financial overhead of approximately £ 640 million .',
  'Deep venous thrombosis ( DVT ) remains a serious clinical problem that affects millions of people worldwide .',
  'Venous thromboembolism is a serious , potentially lethal health problem affecting one per 1,000 people annually .',
  'Venous thromboembolism in family caregivers is a rare but a serious problem .'],
 'thromboembolism': ['Pediatric hospital-acquired ( HA ) venous thromboembolism ( VTE ) is a vexing problem with improvement efforts hampered by lack of robust surveillance methods to establish accurate rates of HA-VTE .',
  'Venous thromboembolism ( VTE ) , which is characterized by pulmonary embolism and deep vein thrombosis , has become a serious public concern .',
  'Venous thromboembolism ( VTE ) and deep vein thrombophlebitis ( DVT ) is a serious problem with high mortality and morbidity rates .',
  'Venous thromboembolism ( VTE ) remains a serious problem , and treatments surrounding this potentially life-threatening disease continue to evolve .',
  'The thrombotic risk of spaceflight : has a serious problem been overlooked for more than half of a century ?',
  'Deep venous thrombosis and pulmonary embolism , together called venous thromboembolism , remain a serious national health problem .',
  'Deep-vein thrombosis ( DVT ) is a serious problem that affects millions of people annually .',
  'Most of the responding surgeons consider venous thromboembolism a serious health problem .',
  'The increasing detection of VTE among Indian population , lack of awareness , underestimation of the risk , and fear of bleeding complications after chemical prophylaxis have made deep vein thrombosis ( DVT ) a serious problem , hence a standard guideline for thromboprophylaxis after trauma is essential .',
  'Thrombus formation remains a serious problem in developing blood compatible materials .',
  'Post-deep vein thrombosis ( DVT ) venous insufficiency is a vexing problem despite effective anticoagulation , and is characterized by vein wall fibrosis .',
  'Venous thromboembolism ( VTE ) is a serious medical problem and is one of the most important preventable causes of mortality and morbidity in hospitalized patients .',
  'Deep vein thrombosis is a serious medical problem that may lead to pulmonary embolus .',
  'Cerebral venous and sinus thrombosis ( CVST ) is still considered a severe clinical problem that is difficult to diagnose and manage and is linked to a poor prognosis .',
  'Deep venous thrombosis ( DVT ) is a serious problem that can potentially lead to many complications including life-threatening pulmonary arterial thrombosis .',
  'In the United States ( U.S. ) , the high morbidity and mortality rates make VTE a serious health concern ( 1 - 2 ) .',
  'Thrombosis is a serious problem in the United States .',
  'Thrombosis is a serious problem , and often leads to irreversible vision loss .',
  'Venous thromboembolism is a serious health problem and a significant cause of morbidity and mortality .',
  'Travel-related thrombosis is a serious public health concern considering the large and increasing number of travellers .',
  'Deep vein thrombosis ( DVT ) and its devastating complication , pulmonary embolism , are a severe health problem with high mortality .',
  'Venous thromboembolism ( VTE ) , comprising deep vein thrombosis and pulmonary embolism , is a serious clinical and public health concern .',
  'Venous thromboembolism ( VTE ) and its manifestations , including deep vein thrombosis ( DVT ) and pulmonary embolism ( PE ) , pose a life-threatening health problem for thousands of people each year .',
  'Venous thromboembolism ( VTE ) is a serious health problem for which pharmacological prophylaxis has been proven to be effective .',
  'Deep Vein Thrombosis ( DVT ) is a life threatening condition and a serious concern among hospitalised patients , with death occurring in approximately 6 % of cases .',
  'Deep vein thrombosis is a severe health problem .',
  'Deep vein thrombosis ( DVT ) is a serious health problem that affects more than 2 million people annually in the United States .',
  'Inappropriate thromboprophylaxis is a serious problem in Iran .',
  'Venous thromboembolism ( VTE ) prophylaxis , despite evidence for its efficacy , is not reliably and consistently prescribed , and is currently a serious concern for patient safety .',
  'These data reveal that DVT is a serious health problem in Spain , with high morbidity and mortality .',
  'Venous thromboembolism ( VTE ) , which includes deep vein thrombosis ( DVT ) and pulmonary embolism ( PE ) , is a serious health and social care problem of the developed world , affecting 1 in 1000 adults every year , and with an annual financial overhead of approximately £ 640 million .',
  'Deep venous thrombosis ( DVT ) remains a serious clinical problem that affects millions of people worldwide .',
  'Venous thromboembolism is a serious , potentially lethal health problem affecting one per 1,000 people annually .',
  'Venous thromboembolism in family caregivers is a rare but a serious problem .'],
 'vein': ['Pediatric hospital-acquired ( HA ) venous thromboembolism ( VTE ) is a vexing problem with improvement efforts hampered by lack of robust surveillance methods to establish accurate rates of HA-VTE .',
  'Venous thromboembolism ( VTE ) , which is characterized by pulmonary embolism and deep vein thrombosis , has become a serious public concern .',
  'Venous thromboembolism ( VTE ) and deep vein thrombophlebitis ( DVT ) is a serious problem with high mortality and morbidity rates .',
  'Venous thromboembolism ( VTE ) remains a serious problem , and treatments surrounding this potentially life-threatening disease continue to evolve .',
  'The thrombotic risk of spaceflight : has a serious problem been overlooked for more than half of a century ?',
  'Deep venous thrombosis and pulmonary embolism , together called venous thromboembolism , remain a serious national health problem .',
  'Deep-vein thrombosis ( DVT ) is a serious problem that affects millions of people annually .',
  'Most of the responding surgeons consider venous thromboembolism a serious health problem .',
  'The increasing detection of VTE among Indian population , lack of awareness , underestimation of the risk , and fear of bleeding complications after chemical prophylaxis have made deep vein thrombosis ( DVT ) a serious problem , hence a standard guideline for thromboprophylaxis after trauma is essential .',
  'Thrombus formation remains a serious problem in developing blood compatible materials .',
  'Post-deep vein thrombosis ( DVT ) venous insufficiency is a vexing problem despite effective anticoagulation , and is characterized by vein wall fibrosis .',
  'Venous thromboembolism ( VTE ) is a serious medical problem and is one of the most important preventable causes of mortality and morbidity in hospitalized patients .',
  'Deep vein thrombosis is a serious medical problem that may lead to pulmonary embolus .',
  'Cerebral venous and sinus thrombosis ( CVST ) is still considered a severe clinical problem that is difficult to diagnose and manage and is linked to a poor prognosis .',
  'Deep venous thrombosis ( DVT ) is a serious problem that can potentially lead to many complications including life-threatening pulmonary arterial thrombosis .',
  'In the United States ( U.S. ) , the high morbidity and mortality rates make VTE a serious health concern ( 1 - 2 ) .',
  'Thrombosis is a serious problem in the United States .',
  'Thrombosis is a serious problem , and often leads to irreversible vision loss .',
  'Venous thromboembolism is a serious health problem and a significant cause of morbidity and mortality .',
  'Travel-related thrombosis is a serious public health concern considering the large and increasing number of travellers .',
  'Deep vein thrombosis ( DVT ) and its devastating complication , pulmonary embolism , are a severe health problem with high mortality .',
  'Venous thromboembolism ( VTE ) , comprising deep vein thrombosis and pulmonary embolism , is a serious clinical and public health concern .',
  'Venous thromboembolism ( VTE ) and its manifestations , including deep vein thrombosis ( DVT ) and pulmonary embolism ( PE ) , pose a life-threatening health problem for thousands of people each year .',
  'Venous thromboembolism ( VTE ) is a serious health problem for which pharmacological prophylaxis has been proven to be effective .',
  'Deep Vein Thrombosis ( DVT ) is a life threatening condition and a serious concern among hospitalised patients , with death occurring in approximately 6 % of cases .',
  'Deep vein thrombosis is a severe health problem .',
  'Deep vein thrombosis ( DVT ) is a serious health problem that affects more than 2 million people annually in the United States .',
  'Inappropriate thromboprophylaxis is a serious problem in Iran .',
  'Venous thromboembolism ( VTE ) prophylaxis , despite evidence for its efficacy , is not reliably and consistently prescribed , and is currently a serious concern for patient safety .',
  'These data reveal that DVT is a serious health problem in Spain , with high morbidity and mortality .',
  'Venous thromboembolism ( VTE ) , which includes deep vein thrombosis ( DVT ) and pulmonary embolism ( PE ) , is a serious health and social care problem of the developed world , affecting 1 in 1000 adults every year , and with an annual financial overhead of approximately £ 640 million .',
  'Deep venous thrombosis ( DVT ) remains a serious clinical problem that affects millions of people worldwide .',
  'Venous thromboembolism is a serious , potentially lethal health problem affecting one per 1,000 people annually .',
  'Venous thromboembolism in family caregivers is a rare but a serious problem .'],
 'embolism': ['Pediatric hospital-acquired ( HA ) venous thromboembolism ( VTE ) is a vexing problem with improvement efforts hampered by lack of robust surveillance methods to establish accurate rates of HA-VTE .',
  'Venous thromboembolism ( VTE ) , which is characterized by pulmonary embolism and deep vein thrombosis , has become a serious public concern .',
  'Pulmonary embolism is also a serious problem that occurs in more than 500,000patients per year , of whom approximately 200,000will die .',
  'Venous thromboembolism ( VTE ) and deep vein thrombophlebitis ( DVT ) is a serious problem with high mortality and morbidity rates .',
  'Venous thromboembolism ( VTE ) remains a serious problem , and treatments surrounding this potentially life-threatening disease continue to evolve .',
  'The thrombotic risk of spaceflight : has a serious problem been overlooked for more than half of a century ?',
  'Deep venous thrombosis and pulmonary embolism , together called venous thromboembolism , remain a serious national health problem .',
  'Deep-vein thrombosis ( DVT ) is a serious problem that affects millions of people annually .',
  'Pulmonary embolism is a serious and difficult problem .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem and computed tomography pulmonary angiography ( CTPA ) is the gold standard for diagnosis .',
  'Most of the responding surgeons consider venous thromboembolism a serious health problem .',
  'Computed tomography pulmonary angiography ( CTPA ) is the standard imaging modality for detection or rule out of pulmonary embolism ( PE ) ; however , radiation exposure is a serious concern .',
  'The increasing detection of VTE among Indian population , lack of awareness , underestimation of the risk , and fear of bleeding complications after chemical prophylaxis have made deep vein thrombosis ( DVT ) a serious problem , hence a standard guideline for thromboprophylaxis after trauma is essential .',
  'Thrombus formation remains a serious problem in developing blood compatible materials .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem , and computed tomographic imaging is the standard for diagnosis .',
  'Post-deep vein thrombosis ( DVT ) venous insufficiency is a vexing problem despite effective anticoagulation , and is characterized by vein wall fibrosis .',
  'Venous thromboembolism ( VTE ) is a serious medical problem and is one of the most important preventable causes of mortality and morbidity in hospitalized patients .',
  'Deep vein thrombosis is a serious medical problem that may lead to pulmonary embolus .',
  'Cerebral venous and sinus thrombosis ( CVST ) is still considered a severe clinical problem that is difficult to diagnose and manage and is linked to a poor prognosis .',
  'Deep venous thrombosis ( DVT ) is a serious problem that can potentially lead to many complications including life-threatening pulmonary arterial thrombosis .',
  'In the United States ( U.S. ) , the high morbidity and mortality rates make VTE a serious health concern ( 1 - 2 ) .',
  'Septic pulmonary embolism is a serious but uncommon syndrome posing diagnostic challenges because of its broad range of clinical presentation and etiologies .',
  'Thrombosis is a serious problem in the United States .',
  'The Pulmonary Embolism Response Team ( PERT ) is a multidisciplinary team that quickly evaluates , coordinates diagnosis , and optimizes management for patients with pulmonary embolism ( PE ) , a serious public health problem .',
  'Diagnosis and management of the patient with pulmonary embolism remains a vexing clinical problem .',
  'Thrombosis is a serious problem , and often leads to irreversible vision loss .',
  'Venous thromboembolism is a serious health problem and a significant cause of morbidity and mortality .',
  'Travel-related thrombosis is a serious public health concern considering the large and increasing number of travellers .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem and computed tomography pulmonary angiography ( CTPA ) is the gold standard for diagnosis .',
  'Deep vein thrombosis ( DVT ) and its devastating complication , pulmonary embolism , are a severe health problem with high mortality .',
  'Venous thromboembolism ( VTE ) , comprising deep vein thrombosis and pulmonary embolism , is a serious clinical and public health concern .',
  'Venous thromboembolism ( VTE ) and its manifestations , including deep vein thrombosis ( DVT ) and pulmonary embolism ( PE ) , pose a life-threatening health problem for thousands of people each year .',
  'Venous thromboembolism ( VTE ) is a serious health problem for which pharmacological prophylaxis has been proven to be effective .',
  'Deep Vein Thrombosis ( DVT ) is a life threatening condition and a serious concern among hospitalised patients , with death occurring in approximately 6 % of cases .',
  'Deep vein thrombosis is a severe health problem .',
  'Deep vein thrombosis ( DVT ) is a serious health problem that affects more than 2 million people annually in the United States .',
  'Inappropriate thromboprophylaxis is a serious problem in Iran .',
  'Venous thromboembolism ( VTE ) prophylaxis , despite evidence for its efficacy , is not reliably and consistently prescribed , and is currently a serious concern for patient safety .',
  'Although massive pulmonary tumor embolism occurs relatively rarely , it can be a catastrophic problem .',
  'These data reveal that DVT is a serious health problem in Spain , with high morbidity and mortality .',
  'Venous thromboembolism ( VTE ) , which includes deep vein thrombosis ( DVT ) and pulmonary embolism ( PE ) , is a serious health and social care problem of the developed world , affecting 1 in 1000 adults every year , and with an annual financial overhead of approximately £ 640 million .',
  'Deep venous thrombosis ( DVT ) remains a serious clinical problem that affects millions of people worldwide .',
  'Venous thromboembolism is a serious , potentially lethal health problem affecting one per 1,000 people annually .',
  'Venous thromboembolism in family caregivers is a rare but a serious problem .'],
 'ulcer': ['We conclude that pressure ulcers represent a serious clinical and economic problem for a resource-constrained public hospital system .',
  'Pressure sores are a serious problem among geriatric patients in nursing homes .',
  'Hospital-acquired pressure ulcers are a serious patient safety concern , associated with poor patient outcomes and high healthcare costs .',
  'The cutaneous ulcer in a patient with a history of international travel poses a vexing diagnostic dilemma for the clinician .',
  'Hospital-acquired pressure ulcers ( HAPUs ) are a serious nosocomial problem that has been viewed as a ubiquitous consequence of immobility .',
  'Paediatric pressure ulcers are a serious problem to healthcare service .',
  'Pressure ulcers are a serious health problem for people with mobility disorders , like elders in acute care , long-term care , and home care settings .',
  'Chronic , nonhealing , cutaneous ulcers are a serious clinical problem .',
  'Pressure ulcers ( PUs ) are a serious health problem .',
  'Pressure ulcers ( PUs ) continue to be a distressing medical problem .',
  'Peptic ulcer perforation is a serious problem that leads to high complication and mortality rates .',
  'Pressure ulcers are a serious national health concern impacting cost of care , reimbursement , and quality of life .',
  'Chronic ulceration as a complication of arteriosclerotic disease , venous congestion or diabetes mellitus is still a serious clinical problem , resulting in immobilization , extended hospitalization and cost-intensive treatment .',
  'Pressure sores are a severe and costly problem for many disabled individuals .',
  'Pressure ulcers are still a serious problem for the hospitalized patient in this country .',
  'Peptic ulcer bleeding is a serious medical problem with significant morbidity and mortality .',
  'The study documents that the development of pressure sores in Danish hospital patients is not a serious quality problem .',
  'Over the years , the aeromedical disposition of aircrew members with bleeding duodenal ulcer has been a vexing problem because two essential questions can not be categorically answered :',
  'The urgency treatment of a life-threatening bleeding for Cameron ulcers remains a very challenging problem as no univocal and standardized recommendation has been described in literature since now .',
  'Pressure sores are a serious but often avoidable problem .',
  'Recurrent pressures sores are a serious problem that often cause chronically ill patients to be hospitalized .',
  'On account of its frequency , its severe sequelae for individual and society and an account of the hitherto insufficient possibilities for prevention and cure the peptic ulcer of the stomach and the duodenum is a severe problem in health policy .',
  'The lower extremity vascular ulcers currently represent a major public health problem , particularly because of different situations : the chronic nature of the injury , a poor response to treatment , recurrence rates , high absenteeism , poor training in some cases of the health staff that treats , etc . Lower extremity ulcers mean a serious personal , family , health and social problem , with a significant expenditure of human and material resources .',
  '1 . Pressure ulcers continue to be a serious problem in nursing home settings .',
  'Pressure ulcer development is a serious problem occurring predominately among elderly persons , who are confined to bed or chair .',
  'Healing of ulcers is a serious problem , but preventing recurrence is the greater challenge .',
  'Pressure ulcers are serious and common health concern affecting about 1.5 - 3 million adults and is a serious health concern for elders .',
  'Pressure ulcer development during a surgical procedure is a serious problem .',
  'Pressure ulcers ( PUs ) are considered a serious problem in nursing care and require preventive measures .',
  'Pressure ulcers on heels are a serious problem in nursing home patients and can lead to complications .',
  'Pressure ulcers are a serious health problem in medical and nursing care .',
  'Pressure ulcer is a serious and persistent problem for patients throughout the Western world .',
  'The Pressure Ulcer Scale for Healing ( PUSH ) represent a serious problem around the world since they have important consequences , personal and economic , this making it a public problem health .',
  'Lower limb ulcers are a serious medical and socioeconomic problem throughout the world .',
  'The data available regarding the epidemiology of pressure ulcers suggest that they are a serious public health problem in the United States , particularly among the elderly .',
  'Pressure ulcers ( PU ) remain a serious healthcare problem in the United States .',
  "Venous crural ulcer is a serious medical problem indeed , which is connected with patients ' suffering and long term treatment generating high cost .",
  'Even in the present , pressure ulcers still represent a severe health problem , particularly in Intensive Care Units ( ICU ) .',
  'Pressure ulcer is a serious problem during patient care processes .',
  'Wound pain is a serious problem for elderly patients suffering from chronic leg ulcers , and it may lead to reduced wound healing rates and reduced quality of life .',
  'Stress induced gastric ulcer is a serious health problem in diabetic patients .',
  'Pressure ulcers are a serious problem that can lead to pain and delayed recovery .',
  'Pressure ulcers , a devastating and costly healthcare problem , often occur in home healthcare settings .',
  'Pressure ulcers remain a serious problem for patients and providers in healthcare .',
  'Varicose ulcers ( UV ) are a serious health problem which produce tremendous pain for those who suffer from them ; furthermore , they consume a large amount of health care system resources .',
  'Pressure ulcers ( PUs ) are a serious health care problem for nursing home residents and a key quality metric for regulators .',
  'Leg ulcers are a serious problem for those affected by them , and health care providers need to be more informed about the effect of chronic health problems on elderly persons .',
  'Preventing and treating pressure ulcers will continue to be a troublesome problem for intensivists .',
  'Pain is a serious problem for patients with leg ulcers .',
  'Peptic ulcer ( PU ) perforation is a serious problem that leads to high complication and mortality rates .',
  'Pressure ulcers are a serious health issue , leading to clinical , financial , and emotional challenges .',
  'Pressure ulcers remain a serious health problem , especially in terms of personal suffering and economics .'],
 'sores': ['We conclude that pressure ulcers represent a serious clinical and economic problem for a resource-constrained public hospital system .',
  'Pressure sores are a serious problem among geriatric patients in nursing homes .',
  'Hospital-acquired pressure ulcers are a serious patient safety concern , associated with poor patient outcomes and high healthcare costs .',
  'Hospital-acquired pressure ulcers ( HAPUs ) are a serious nosocomial problem that has been viewed as a ubiquitous consequence of immobility .',
  'Paediatric pressure ulcers are a serious problem to healthcare service .',
  'Pressure ulcers are a serious health problem for people with mobility disorders , like elders in acute care , long-term care , and home care settings .',
  'Pressure ulcers ( PUs ) are a serious health problem .',
  'Pressure ulcers ( PUs ) continue to be a distressing medical problem .',
  'Peptic ulcer perforation is a serious problem that leads to high complication and mortality rates .',
  'Pressure ulcers are a serious national health concern impacting cost of care , reimbursement , and quality of life .',
  'Pressure sores are a severe and costly problem for many disabled individuals .',
  'Pressure ulcers are still a serious problem for the hospitalized patient in this country .',
  'Peptic ulcer bleeding is a serious medical problem with significant morbidity and mortality .',
  'The study documents that the development of pressure sores in Danish hospital patients is not a serious quality problem .',
  'Over the years , the aeromedical disposition of aircrew members with bleeding duodenal ulcer has been a vexing problem because two essential questions can not be categorically answered :',
  'Pressure sores are a serious but often avoidable problem .',
  'Recurrent pressures sores are a serious problem that often cause chronically ill patients to be hospitalized .',
  'On account of its frequency , its severe sequelae for individual and society and an account of the hitherto insufficient possibilities for prevention and cure the peptic ulcer of the stomach and the duodenum is a severe problem in health policy .',
  '1 . Pressure ulcers continue to be a serious problem in nursing home settings .',
  'Pressure ulcer development is a serious problem occurring predominately among elderly persons , who are confined to bed or chair .',
  'Pressure ulcers are serious and common health concern affecting about 1.5 - 3 million adults and is a serious health concern for elders .',
  'Pressure ulcer development during a surgical procedure is a serious problem .',
  'Pressure ulcers ( PUs ) are considered a serious problem in nursing care and require preventive measures .',
  'Pressure ulcers on heels are a serious problem in nursing home patients and can lead to complications .',
  'Pressure ulcers are a serious health problem in medical and nursing care .',
  'Pressure ulcer is a serious and persistent problem for patients throughout the Western world .',
  'The Pressure Ulcer Scale for Healing ( PUSH ) represent a serious problem around the world since they have important consequences , personal and economic , this making it a public problem health .',
  'The data available regarding the epidemiology of pressure ulcers suggest that they are a serious public health problem in the United States , particularly among the elderly .',
  'Pressure ulcers ( PU ) remain a serious healthcare problem in the United States .',
  'Even in the present , pressure ulcers still represent a severe health problem , particularly in Intensive Care Units ( ICU ) .',
  'Pressure ulcer is a serious problem during patient care processes .',
  'Pressure ulcers are a serious problem that can lead to pain and delayed recovery .',
  'Pressure ulcers , a devastating and costly healthcare problem , often occur in home healthcare settings .',
  'Pressure ulcers remain a serious problem for patients and providers in healthcare .',
  'Pressure ulcers ( PUs ) are a serious health care problem for nursing home residents and a key quality metric for regulators .',
  'Preventing and treating pressure ulcers will continue to be a troublesome problem for intensivists .',
  'Peptic ulcer ( PU ) perforation is a serious problem that leads to high complication and mortality rates .',
  'Pressure ulcers are a serious health issue , leading to clinical , financial , and emotional challenges .',
  'Pressure ulcers remain a serious health problem , especially in terms of personal suffering and economics .'],
 'pus': ['We conclude that pressure ulcers represent a serious clinical and economic problem for a resource-constrained public hospital system .',
  'Pressure sores are a serious problem among geriatric patients in nursing homes .',
  'Hospital-acquired pressure ulcers are a serious patient safety concern , associated with poor patient outcomes and high healthcare costs .',
  'Hospital-acquired pressure ulcers ( HAPUs ) are a serious nosocomial problem that has been viewed as a ubiquitous consequence of immobility .',
  'Paediatric pressure ulcers are a serious problem to healthcare service .',
  'Pressure ulcers are a serious health problem for people with mobility disorders , like elders in acute care , long-term care , and home care settings .',
  'Pressure ulcers ( PUs ) are a serious health problem .',
  'Pressure ulcers ( PUs ) continue to be a distressing medical problem .',
  'Peptic ulcer perforation is a serious problem that leads to high complication and mortality rates .',
  'Pressure ulcers are a serious national health concern impacting cost of care , reimbursement , and quality of life .',
  'Pressure sores are a severe and costly problem for many disabled individuals .',
  'Pressure ulcers are still a serious problem for the hospitalized patient in this country .',
  'Peptic ulcer bleeding is a serious medical problem with significant morbidity and mortality .',
  'The study documents that the development of pressure sores in Danish hospital patients is not a serious quality problem .',
  'Over the years , the aeromedical disposition of aircrew members with bleeding duodenal ulcer has been a vexing problem because two essential questions can not be categorically answered :',
  'Pressure sores are a serious but often avoidable problem .',
  'Recurrent pressures sores are a serious problem that often cause chronically ill patients to be hospitalized .',
  'On account of its frequency , its severe sequelae for individual and society and an account of the hitherto insufficient possibilities for prevention and cure the peptic ulcer of the stomach and the duodenum is a severe problem in health policy .',
  '1 . Pressure ulcers continue to be a serious problem in nursing home settings .',
  'Pressure ulcer development is a serious problem occurring predominately among elderly persons , who are confined to bed or chair .',
  'Pressure ulcers are serious and common health concern affecting about 1.5 - 3 million adults and is a serious health concern for elders .',
  'Pressure ulcer development during a surgical procedure is a serious problem .',
  'Pressure ulcers ( PUs ) are considered a serious problem in nursing care and require preventive measures .',
  'Pressure ulcers on heels are a serious problem in nursing home patients and can lead to complications .',
  'Pressure ulcers are a serious health problem in medical and nursing care .',
  'Pressure ulcer is a serious and persistent problem for patients throughout the Western world .',
  'The Pressure Ulcer Scale for Healing ( PUSH ) represent a serious problem around the world since they have important consequences , personal and economic , this making it a public problem health .',
  'The data available regarding the epidemiology of pressure ulcers suggest that they are a serious public health problem in the United States , particularly among the elderly .',
  'Pressure ulcers ( PU ) remain a serious healthcare problem in the United States .',
  'Even in the present , pressure ulcers still represent a severe health problem , particularly in Intensive Care Units ( ICU ) .',
  'Pressure ulcer is a serious problem during patient care processes .',
  'Pressure ulcers are a serious problem that can lead to pain and delayed recovery .',
  'Pressure ulcers , a devastating and costly healthcare problem , often occur in home healthcare settings .',
  'Pressure ulcers remain a serious problem for patients and providers in healthcare .',
  'Pressure ulcers ( PUs ) are a serious health care problem for nursing home residents and a key quality metric for regulators .',
  'Preventing and treating pressure ulcers will continue to be a troublesome problem for intensivists .',
  'Peptic ulcer ( PU ) perforation is a serious problem that leads to high complication and mortality rates .',
  'Pressure ulcers are a serious health issue , leading to clinical , financial , and emotional challenges .',
  'Pressure ulcers remain a serious health problem , especially in terms of personal suffering and economics .'],
 'cadmium': ['Cadmium ( Cd ) pollution is a serious global problem , which causes irreversible toxic effects on animals .',
  'Although acute or chronic effects of the chemical contamination of shellfish have not been clearly documented , the cadmium pollution of some shellfish harvesting waters raises a serious problem .',
  'Accumulation of cadmium ( Cd ) shows a serious problem for the environment and poses a threat to plants .',
  'As more issues have arisen in China due to rice contaminated by cadmium ( Cd ) , Cd contamination in arable soils has become a severe problem .',
  'Cd pollution in farmland is becoming a serious problem because it affects the safety of rice production and human health .',
  'As soil cadmium ( Cd ) contamination becomes a serious concern and one of the significant environmental pollution issues all over the world , knowledge of the basic chemistry , origin , inputs , sources , quantity , chemical forms , reactions , as well as the fate and transport of Cd in different types of soil is crucial for better understanding Cd bioavailability , health risks and remedial options .',
  'Accumulation of Cd in rice grain is a serious concern of food safety since rice as a staple food is a major source of Cd intake in Asian countries .',
  'Higher pH decreases the t 1/2 of Cd in soil solution , indicating that higher pH ( alkaline ) is not a serious concern in Cd toxicity than lower pH ( acidic ) .',
  "Cadmium ( Cd ) exposure poses a serious environmental problem due to the metal 's bioaccumulation and difficult to eliminate from body .",
  'Soil contamination with toxic heavy metals [ such as cadmium ( Cd ) ] is becoming a serious global problem due to rapid development of social economy .',
  'Both cadmium ( Cd ) contamination in agricultural soils and drought stress pose a serious problem for crop quality and human health .',
  'The contamination of large areas of arable land with cadmium ( Cd ) is a serious concern worldwide and environmentally feasible amendments are necessary to minimize Cd accumulation in cereals such as rice ( Oryza sativa L. ) .',
  'Cadmium nephrotoxicity is a serious environmental health problem as it will eventually end up with end stage renal disease .',
  'Contamination of soils with cadmium ( Cd ) is a serious problem worldwide .',
  'Cadmium ( Cd ) contaminated in rice grains is a serious problem because most Asians consume rice on a daily basis .',
  'The pollution of agricultural soils with cadmium ( Cd ) has become a serious problem worldwide .',
  'Cadmium ( Cd ) stress is a serious concern in agricultural soils worldwide , and increasing accumulation and subsequent transfer to humans via the food chain can have potentially harmful effects .',
  'Cadmium pollution has become a serious environmental problem .',
  'Cadmium (Cd)-contaminated rice is a serious health concern .',
  'Soil contamination with Cd from P fertilizer and other anthropogenic and geogenic sources is a serious problem .',
  'Contamination of cadmium ( Cd ) in paddy soil is a serious environmental problem threatening food safety in some parts of southern China , where rice grain Cd concentration often exceeds the Chinese limit ( 0.2 \u202f mg \u202f kg',
  'Contamination of soils with cadmium ( Cd ) is a serious problem worldwide .',
  'Soil Cd pollution resulting from human activities has become a serious food safety concern .',
  'Cadmium ( Cd ) contamination in red soil has become a serious environmental concern due to its toxic effects on organisms and the food chain .',
  'Soil cadmium ( Cd ) contamination in China has become a serious concern due to its high toxicity to human health through food chains .',
  "Cadmium poisoning poses a serious health concern due to cadmium 's increasing industrial use , yet there is currently no recommended treatment .",
  "Ubiquity of Cd makes it a serious environmental health problem that needs to be thoroughly assessed because it already affects or will affect large proportions of the world 's population .",
  'Agricultural soils contamination with cadmium ( Cd ) has become a serious concern through anthropogenic activities .',
  'Cadmium ( Cd ) contamination poses a serious problem in paddy soils .',
  'Soil cadmium ( Cd ) contamination has become a serious problem in China .',
  'Copper and cadmium in soil is a severe soil pollution problem in China .',
  'Cadmium ( Cd ) pollution is a serious environmental problem .',
  'Cadmium ( Cd ) contamination is a serious food safety problem .',
  'Cadmium ( Cd ) pollution is a serious widespread environmental problem that not only destroys the microbial ecology of soil and decreases crop production , but also poses a serious risk to human health .',
  'Soil contamination by cadmium ( Cd ) poses a serious environmental and public health concern .',
  'Cadmium contamination is a serious environmental problem for modern agriculture and human health .',
  'Food chain contamination by cadmium ( Cd ) is globally a serious health concern resulting in chronic abnormalities .',
  'Heavy metals contamination of soil especially with cadmium ( Cd ) is a serious environmental concern in the current industrial era .',
  'Soil cadmium ( Cd ) contamination has posed a serious problem for safe food production and become a potential agricultural and environmental hazard worldwide .',
  'Cadmium ( Cd ) , which is a deadly heavy metal of work-related and environmental concern , has been recognized as a substance that is teratogenic and carcinogenic for humans .',
  'Cadmium is a toxic and carcinogenic heavy metal that nowadays constitutes a serious environmental health problem .',
  'Cadmium ( Cd ) contamination in soils has become a serious and widespread environmental problem , especially in areas with high natural background Cd values , but the mechanism of Cd enrichment in these areas is still unclear .',
  'Cadmium ( Cd ) pollution in soil is a serious problem affecting environmental safety and human health , and the majority of Cd in human body comes from edible vegetables , especially leafy vegetables .',
  'Cadmium contamination of agricultural soils is a serious problem due to its toxic effects on health and yield of crop plants .'],
 'acinetobacter': ['Carbapenem resistance among MDR ( CR-MDR ) P. aeruginosa has become a serious life-threatening problem due to the limited therapeutic options .',
  'Drug resistance of clinically isolated Acinetobacter baumannii is a serious problem in two hospitals ; drug-resistant strains are spread and epidemic among wards and hospitals .',
  'The increasing prevalence and global spread of carbapenem-resistant Acinetobacter baumannii ( A. baumannii ) has become a serious problem .',
  'Acanthamoeba infection caused is a serious clinical problem mainly due to limited progress in diagnostics and treatment of this infection , which is associated with insufficient knowledge of pathogenesis , pathophysiology and the host immune response against Acanthamoeba antigens .',
  'The global emergence of colistin resistance in carbapenem-resistant Acinetobacter baumannii ( CRAB ) clinical isolates is a serious public health concern .',
  'Infections caused by multidrug-resistant Acinetobacter baumannii have emerged as a serious global health problem .',
  'The increased incidence of multidrug-resistant ( MDR ) Acinetobacter baumannii ventilator-associated pneumonia in critically ill patients poses a severe therapeutic problem .',
  'A. baumannii has become resistant to most of the commonly used antibiotics and multidrug-resistant isolates are becoming a severe problem in the healthcare setting .',
  'Acinetobacter bacteremia represents a serious and ever increasing problem because of the high associated morbidity and mortality .',
  'Carbapenem resistance among Acinetobacter species has become a life-threatening problem .',
  'Nosocomial infections caused by multidrug resistant Acinetobacter baumannii have emerged as a serious problem in healthcare settings worldwide .',
  'Nosocomial infections and persistence of multidrug resistant biofilm forming Acinetobacter baumannii in hospitals has made it as a serious problem in healthcare settings worldwide .',
  'In recent years A.baumannii has become a serious clinical problem because of the development of resistance to many antibiotics , and especially to carbapenems .',
  'The increasing prevalence and global spread of difficult-to-treat carbapenem-resistant Acinetobacter baumannii has become a serious problem .',
  'The increase in the prevalence of multidrug-resistant Acinetobacter baumannii infections in hospital settings has rapidly emerged worldwide as a serious health problem .',
  'The increasing antibiotic resistance of Acinetobacter species in both natural and hospital environments has become a serious problem worldwide in recent decades .',
  'Acinetobacter baumannii has emerged as a serious problem in the hospital environment at a global scale .',
  'Carbapenem-resistant Acinetobacter ( CRA ) is becoming a serious concern with increasing patient morbidity , mortality , and lengths of hospital stay .',
  'Colistin resistance among extensively-resistant Acinetobacter baumannii isolates is a serious health-care problem .',
  'The treatment of multidrug-resistant Acinetobacter baumannii meningitis is a serious therapeutic problem due to the limited penetration of antibiotics into the CSF .',
  'Nosocomial infections caused by multi-drug resistant Acinetobacter pose a serious problem in many countries .',
  'The spread of Acinetobacter baumannii , resistant to most of the available antimicrobial agents , is a serious health problem .',
  'The emergence of multiple-carbapenemase-producing Acinetobacter strains has been a serious concern during the past decade .',
  'The increasing incidence of A. baumannii is a serious concern , therefore control of this pathogen and taking preventive measures are emphasized .',
  'Acquired carbapenem resistance among non-fermenting Gram-negative bacilli ( NFGNB ) , such as Pseudomonas aeruginosa and Acinetobacter calcoaceticus-Acinetobacter baumannii complex ( ACB complex ) , is a serious problem in nosocomial infections .',
  'Nosocomial infection caused by Acinetobacter baumannii has emerged as a serious problem world-wide .',
  'Presently , multidrug-resistant A. \xa0 baumannii is a serious health concern in hospitals and long-term care facilities and requires immediate and sustained prevention efforts to control the rate of incidence .',
  'Acinetobacter baumannii has become a serious concern in clinical practice owing to its multiple resistance to antimicrobial agents .',
  'Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea .',
  'Extensive drug resistance of Acinetobacter baumannii is a serious problem in the clinical setting .',
  'Multiple drug resistance of clinically isolated Acinetobacter baumannii is a serious problem in Changsha .',
  'Acinetobacter baumannii carbapeneme-resistance is a serious problem due to the difficulty encountered in treating patients infected with this type of multiresistant bacteria .',
  'MDR/XDR Acinetobacter baumannii infection is a serious concern in pediatric patients with high mortality .',
  'Multidrug-resistant strains of Acinetobacter pose a serious therapeutic dilemma in hospital practice , particularly when they cause meningitis , as the few antimicrobial agents to which these isolates are susceptible have poor central nervous system ( CNS ) penetration .',
  'The emergence of multidrug-resistant ( MDR ) Acinetobacter baumannii has become a serious medical problem worldwide .',
  'Even though meningitis caused by Acinetobacter baumannii is relatively rare , it is associated with high mortality rates especially in neurosurgery patients and represents a serious therapeutic problem due to the limited penetration of effective antibiotics into the cerebrospinal fluid .',
  'The increase in the prevalence of multidrug-resistant Acinetobacter baumannii ( MDRAB ) strains is a serious public health concern .',
  'In summary , it is clear from our findings and those of other studies that carbapenem resistance among A. baumannii strains presents a serious clinical problem worldwide .',
  'Evidently , pan-resistant Acinetobacter spp . will become a serious health problem in the near future , unless efficient and appropriate precautions are taken .',
  'Acinetobacter baumannii is a serious concern amongst hospitalised patients worldwide and its resistance to antibiotics has emerged as a threat to public health in recent years .',
  'Acinetobacter baumannii has been a dreadful problem for ICU physicians for a long time .',
  'The high rates of HLAR may cause a serious problem for combination therapy of aminoglycoside with β-lactams against A. baumannii infections .',
  'Acinetobacter baumannii constitutes a dreadful problem in many ICUs worldwide .',
  'The increase in the prevalence of drug-resistant Acinetobacter baumannii is a serious public health concern , which is closely linked to the formation of biofilm .',
  'Acinetobacter baumannii-induced nosocomial pneumonia has become a serious clinical problem because of high antibiotic resistance rates .',
  'Emergence and spread of specific carbapenem-resistant Acinetobacter baumannii ( CRAB ) clones cause a serious therapeutic problem .',
  'Carbapenem-resistant A. baumannii is a serious problem in diabetic patients , and molecular detection of resistance mechanisms in these isolates is required .'],
 'carbapenem': ['Carbapenem resistance among MDR ( CR-MDR ) P. aeruginosa has become a serious life-threatening problem due to the limited therapeutic options .',
  'Drug resistance of clinically isolated Acinetobacter baumannii is a serious problem in two hospitals ; drug-resistant strains are spread and epidemic among wards and hospitals .',
  'The emergence and rapid spread of carbapenemase-producing Enterobacterales represents a serious public health concern .',
  'The increasing prevalence and global spread of carbapenem-resistant Acinetobacter baumannii ( A. baumannii ) has become a serious problem .',
  'Acanthamoeba infection caused is a serious clinical problem mainly due to limited progress in diagnostics and treatment of this infection , which is associated with insufficient knowledge of pathogenesis , pathophysiology and the host immune response against Acanthamoeba antigens .',
  'The global emergence of colistin resistance in carbapenem-resistant Acinetobacter baumannii ( CRAB ) clinical isolates is a serious public health concern .',
  'We detected and reported the first Japanese case of KPC-2 carbapenemase-producing Klebsiella pneumoniae , of which infection will be a serious problem in the near future in Japan .',
  'Infections caused by multidrug-resistant Acinetobacter baumannii have emerged as a serious global health problem .',
  'The increased incidence of multidrug-resistant ( MDR ) Acinetobacter baumannii ventilator-associated pneumonia in critically ill patients poses a severe therapeutic problem .',
  'A. baumannii has become resistant to most of the commonly used antibiotics and multidrug-resistant isolates are becoming a severe problem in the healthcare setting .',
  'Acinetobacter bacteremia represents a serious and ever increasing problem because of the high associated morbidity and mortality .',
  'Carbapenem resistance among Acinetobacter species has become a life-threatening problem .',
  'The emergence of carbapenem resistant Escherichia coli represents a serious public health concern .',
  'The Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae has become a serious problem because the species is wide ranging and there are few treatment options .',
  'Nosocomial infections caused by multidrug resistant Acinetobacter baumannii have emerged as a serious problem in healthcare settings worldwide .',
  'Nosocomial infections and persistence of multidrug resistant biofilm forming Acinetobacter baumannii in hospitals has made it as a serious problem in healthcare settings worldwide .',
  'Carbapenem-resistant organism ( CRO ) colonization is a serious problem that increases the risk of infection and contributes to dissemination of antimicrobial resistance in healthcare-associated environments .',
  'Carbapenem resistant Enterobacteriaceae ( CRE ) has become a serious public health problem .',
  'The emergence and spread of carbapenemase-producing Gram-negative bacteria represents a serious public health concern .',
  'This Gram-negative bacterium species has become a serious concern due to its dramatic increase in the levels of multiple antibiotic resistances , particularly to carbapenems .',
  'In recent years A.baumannii has become a serious clinical problem because of the development of resistance to many antibiotics , and especially to carbapenems .',
  'Infections caused by carbapenem-resistant enterobacteria ( CRE ) are classified as a serious problem .',
  'Carbapenem-resistant Gram-negative pathogens have progressively disseminated to different countries worldwide , presenting a serious public health concern .',
  'The increasing prevalence and global spread of difficult-to-treat carbapenem-resistant Acinetobacter baumannii has become a serious problem .',
  'The increase in the prevalence of multidrug-resistant Acinetobacter baumannii infections in hospital settings has rapidly emerged worldwide as a serious health problem .',
  'The increasing incidence of carbapenemase-producing K. pneumoniae strains ( CP-Kps ) in the last decade has become a serious global healthcare problem .',
  'The increasing antibiotic resistance of Acinetobacter species in both natural and hospital environments has become a serious problem worldwide in recent decades .',
  'Acinetobacter baumannii has emerged as a serious problem in the hospital environment at a global scale .',
  'The emergence and spread of Carbapenem-resistant Escherichia coli ( CREC ) is becoming a serious problem in Chinese hospitals , however , the data on this is scarce .',
  'The spread of plasmids carrying carbapenemase genes resulting in fulminant antimicrobial resistance is a severe concern .',
  'Carbapenem-resistant Acinetobacter ( CRA ) is becoming a serious concern with increasing patient morbidity , mortality , and lengths of hospital stay .',
  'The increasing spread of carbapenem resistance is a serious global public health concern that negatively affects human and animal health .',
  'Within the last decade , human infections caused by enterobacteria which produce the Klebsiella pneumoniae carbapenemase ( KPC ) became a serious therapeutic and epidemiological problem worldwide .',
  'Carbapenem-resistant Enterobacteriaceae infections are a serious health care problem , because of the high mortality .',
  'Colistin resistance among extensively-resistant Acinetobacter baumannii isolates is a serious health-care problem .',
  'Multidrug resistant bacteria are a serious worldwide problem , especially carbapenem-resistant',
  'The treatment of multidrug-resistant Acinetobacter baumannii meningitis is a serious therapeutic problem due to the limited penetration of antibiotics into the CSF .',
  'Rapid dissemination of carbapenemase-producing Enterobacteriaceae is a serious concern in patient care and is a problem that has emerged in western Europe .',
  'Nosocomial infections caused by multi-drug resistant Acinetobacter pose a serious problem in many countries .',
  'The spread of Acinetobacter baumannii , resistant to most of the available antimicrobial agents , is a serious health problem .',
  'The emergence of multiple-carbapenemase-producing Acinetobacter strains has been a serious concern during the past decade .',
  'The development of colistin resistance in carbapenem-resistant strains poses a serious public health problem .',
  'Infections with Carbapenem-Resistant Gram-Negative Bacteria are a Serious Problem Among Critically Ill Children : A Single-Centre Retrospective Study .',
  'The increasing incidence of A. baumannii is a serious concern , therefore control of this pathogen and taking preventive measures are emphasized .',
  'Acquired carbapenem resistance among non-fermenting Gram-negative bacilli ( NFGNB ) , such as Pseudomonas aeruginosa and Acinetobacter calcoaceticus-Acinetobacter baumannii complex ( ACB complex ) , is a serious problem in nosocomial infections .',
  'Nosocomial infection caused by Acinetobacter baumannii has emerged as a serious problem world-wide .',
  'Presently , multidrug-resistant A. \xa0 baumannii is a serious health concern in hospitals and long-term care facilities and requires immediate and sustained prevention efforts to control the rate of incidence .',
  'The transmission of hospital-acquired Carbapenem-resistant Enterobacteriaceae ( CRE ) is a serious and growing concern in hospitals worldwide .',
  'Carbapenem-resistant Klebsiella pneumoniae ( CRKP ) spread and infections in patients with haematological malignancies are a serious concern especially in endemic areas .',
  'Acinetobacter baumannii has become a serious concern in clinical practice owing to its multiple resistance to antimicrobial agents .',
  'Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea .',
  'Extensive drug resistance of Acinetobacter baumannii is a serious problem in the clinical setting .',
  'KPC-producing Klebsiella pneumoniae ( KPC-Kp ) represent a serious problem worldwide .',
  'Multiple drug resistance of clinically isolated Acinetobacter baumannii is a serious problem in Changsha .',
  'Acinetobacter baumannii carbapeneme-resistance is a serious problem due to the difficulty encountered in treating patients infected with this type of multiresistant bacteria .',
  'MDR/XDR Acinetobacter baumannii infection is a serious concern in pediatric patients with high mortality .',
  'Multidrug-resistant strains of Acinetobacter pose a serious therapeutic dilemma in hospital practice , particularly when they cause meningitis , as the few antimicrobial agents to which these isolates are susceptible have poor central nervous system ( CNS ) penetration .',
  'The emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management .',
  'The emergence of multidrug-resistant ( MDR ) Acinetobacter baumannii has become a serious medical problem worldwide .',
  'Even though meningitis caused by Acinetobacter baumannii is relatively rare , it is associated with high mortality rates especially in neurosurgery patients and represents a serious therapeutic problem due to the limited penetration of effective antibiotics into the cerebrospinal fluid .',
  'The increase in the prevalence of multidrug-resistant Acinetobacter baumannii ( MDRAB ) strains is a serious public health concern .',
  'In summary , it is clear from our findings and those of other studies that carbapenem resistance among A. baumannii strains presents a serious clinical problem worldwide .',
  'Evidently , pan-resistant Acinetobacter spp . will become a serious health problem in the near future , unless efficient and appropriate precautions are taken .',
  'Acinetobacter baumannii is a serious concern amongst hospitalised patients worldwide and its resistance to antibiotics has emerged as a threat to public health in recent years .',
  'The dissemination of carbapenemase-producing Enterobacteriaceae is currently considered a serious clinical problem due to the failure in the treatment of infections produced by them .',
  'Acinetobacter baumannii has been a dreadful problem for ICU physicians for a long time .',
  'The high rates of HLAR may cause a serious problem for combination therapy of aminoglycoside with β-lactams against A. baumannii infections .',
  'Acinetobacter baumannii constitutes a dreadful problem in many ICUs worldwide .',
  'Carbapenem-resistant Klebsiella pneumoniae ( CRKP ) infection is a serious problem in hospitals worldwide , posing a particular risk to immunocompromised patients .',
  'Carbapenemase-producing Enterobacteriaceae ( CPE ) are a serious public health concern and represent a major threat to immunocompromised hosts , including solid organ ( SOT ) and stem cell transplant ( HSCT ) recipients .',
  'The increase in the prevalence of drug-resistant Acinetobacter baumannii is a serious public health concern , which is closely linked to the formation of biofilm .',
  'The spread of carbapenemase-producing Klebsiella pneumoniae ( CPKP ) worldwide is a serious problem .',
  'The outbreak of carbapenem-resistant Klebsiella pneumoniae is a serious public health problem , especially in the neonatal intensive care unit (NICU).Fifteen K. pneumoniae strains were isolated from 7 neonates during June 3 to 28 , 2017 in an NICU .',
  'Acinetobacter baumannii-induced nosocomial pneumonia has become a serious clinical problem because of high antibiotic resistance rates .',
  'Emergence and spread of specific carbapenem-resistant Acinetobacter baumannii ( CRAB ) clones cause a serious therapeutic problem .',
  'Carbapenem-resistant A. baumannii is a serious problem in diabetic patients , and molecular detection of resistance mechanisms in these isolates is required .'],
 'eutrophication': ['Eutrophication is a serious problem in Polish freshwaters .',
  'Eutrophication is a serious problem of water body pollution .',
  'Eutrophication due to uncontrolled discharges of nitrogen and phosphorus has become a serious pollution problem in many Chinese rivers .',
  'Lake eutrophication has become a serious environmental problem in China .',
  'Lakes are versatile ecosystems and their eutrophication is a serious problem .',
  'Diffusion limitation of phosphate possibly constitutes a serious problem regarding the use of a biofilm reactor for enhanced biological phosphorus removal .',
  'Phosphogypsum ( PG ) is an acidic by-product from the phosphate fertilizer industry and it is characterized by a low nutrient availability and the presence of radionuclides and heavy metals which pose a serious problem in its management .',
  'There was an overall consensus that eutrophication is a serious problem .',
  'Eutrophication is a serious problem in Chinese seas .',
  'Eutrophication is a serious problem of water resource management in Taiwan .',
  'Phosphorus ( P ) eutrophication of lakes and streams , coming from drained farmlands , is a serious problem in areas with intensive agriculture .',
  'Eutrophic sediment is a serious problem in ecosystem restoration , especially in shallow lake ecosystems .',
  'Eutrophication of coastal waters is a serious environmental problem with high costs for society globally .',
  'Eutrophication and hypoxia within aquatic systems are a serious international concern .',
  'Eutrophication is a serious water quality problem in estuaries receiving increasing anthropogenic nutrient loads .',
  'Excessive P application through mineral fertilizer in the arable farming system has led to the accumulation of soil P and constituted a risk to the recipient water quality , whereas the grassland grazing system is confronted with a severe P deficit problem which has resulted in widespread grass degradation .',
  'Phosphorus in water eutrophication has become a serious problem threatening the environment .',
  'Phosphorus ( P ) leaching from agricultural soils is a serious environmental concern .',
  'Lake eutrophication has become a serious environmental problem in China .',
  'Inorganic phosphate ( Pi ) depletion is a serious problem for plant growth .',
  'Phosphorus eutrophication of lakes and streams , coming from drained farmlands , is a serious problem in areas with intensive agriculture .',
  'Eutrophication has become a severe environmental problem in some tributaries of the Three Gorges Reservoir ( TGR ) in China .',
  'Eutrophication of water bodies is a serious and widespread environmental problem .',
  'Agricultural non-point source phosphorus pollution is a severe problem for rural water bodies in China , but hard to control directly because of its special characteristics .',
  'Nonpoint phosphorus ( P ) pollution from animal manure is becoming a serious global problem .',
  'In order to develop a method of predicting and assessing pond eutrophication , which is a serious environmental problem , and to propose effective measure of improvement of water quality .',
  'Phosphorous ( P ) fixation in alkaline calcareous soils is a serious concern worldwide and acidified-biochar application has been proposed to improve the agronomic benefits of applied P. The present study aims to improve understanding of P transformation process in an alkaline soil following different biochar amendments ( rice-husk biochar ( RHB ) , sugarcane-bagasse biochar ( SWB ) and wheat-straw biochar ( WSB ) ) , chemically engineered ( acidification with 1 \xa0 N HCl or washing with distilled water ( pristine biochar ) ) along with or without P at 60 \xa0 mg \xa0 kg',
  'Phosphogypsum , a waste by-product derived from the wet process production of phosphoric acid , represents a serious problem facing the phosphate industry in Brazil .',
  'Shortage in phosphorus ( P ) resources and P wastewater pollution is considered as a serious problem worldwide .'],
 'freshwaters': ['Eutrophication is a serious problem in Polish freshwaters .',
  'Eutrophication is a serious problem of water body pollution .',
  'Eutrophication due to uncontrolled discharges of nitrogen and phosphorus has become a serious pollution problem in many Chinese rivers .',
  'Lake eutrophication has become a serious environmental problem in China .',
  'Lakes are versatile ecosystems and their eutrophication is a serious problem .',
  'There was an overall consensus that eutrophication is a serious problem .',
  'Eutrophication is a serious problem in Chinese seas .',
  'Eutrophication is a serious problem of water resource management in Taiwan .',
  'Eutrophic sediment is a serious problem in ecosystem restoration , especially in shallow lake ecosystems .',
  'Eutrophication of coastal waters is a serious environmental problem with high costs for society globally .',
  'Eutrophication and hypoxia within aquatic systems are a serious international concern .',
  'Eutrophication is a serious water quality problem in estuaries receiving increasing anthropogenic nutrient loads .',
  'Lake eutrophication has become a serious environmental problem in China .',
  'Eutrophication has become a severe environmental problem in some tributaries of the Three Gorges Reservoir ( TGR ) in China .',
  'Eutrophication of water bodies is a serious and widespread environmental problem .',
  'In order to develop a method of predicting and assessing pond eutrophication , which is a serious environmental problem , and to propose effective measure of improvement of water quality .'],
 'tributaries': ['Eutrophication is a serious problem in Polish freshwaters .',
  'Eutrophication is a serious problem of water body pollution .',
  'Eutrophication due to uncontrolled discharges of nitrogen and phosphorus has become a serious pollution problem in many Chinese rivers .',
  'Lake eutrophication has become a serious environmental problem in China .',
  'Lakes are versatile ecosystems and their eutrophication is a serious problem .',
  'There was an overall consensus that eutrophication is a serious problem .',
  'Eutrophication is a serious problem in Chinese seas .',
  'Eutrophication is a serious problem of water resource management in Taiwan .',
  'Eutrophic sediment is a serious problem in ecosystem restoration , especially in shallow lake ecosystems .',
  'Eutrophication of coastal waters is a serious environmental problem with high costs for society globally .',
  'Eutrophication and hypoxia within aquatic systems are a serious international concern .',
  'Eutrophication is a serious water quality problem in estuaries receiving increasing anthropogenic nutrient loads .',
  'Lake eutrophication has become a serious environmental problem in China .',
  'Eutrophication has become a severe environmental problem in some tributaries of the Three Gorges Reservoir ( TGR ) in China .',
  'Eutrophication of water bodies is a serious and widespread environmental problem .',
  'In order to develop a method of predicting and assessing pond eutrophication , which is a serious environmental problem , and to propose effective measure of improvement of water quality .'],
 'ecosystems': ['Eutrophication is a serious problem in Polish freshwaters .',
  'Eutrophication is a serious problem of water body pollution .',
  'Eutrophication due to uncontrolled discharges of nitrogen and phosphorus has become a serious pollution problem in many Chinese rivers .',
  'Lake eutrophication has become a serious environmental problem in China .',
  'Lakes are versatile ecosystems and their eutrophication is a serious problem .',
  'There was an overall consensus that eutrophication is a serious problem .',
  'Eutrophication is a serious problem in Chinese seas .',
  'Eutrophication is a serious problem of water resource management in Taiwan .',
  'Eutrophic sediment is a serious problem in ecosystem restoration , especially in shallow lake ecosystems .',
  'Eutrophication of coastal waters is a serious environmental problem with high costs for society globally .',
  'Eutrophication and hypoxia within aquatic systems are a serious international concern .',
  'Eutrophication is a serious water quality problem in estuaries receiving increasing anthropogenic nutrient loads .',
  'Lake eutrophication has become a serious environmental problem in China .',
  'Eutrophication has become a severe environmental problem in some tributaries of the Three Gorges Reservoir ( TGR ) in China .',
  'Eutrophication of water bodies is a serious and widespread environmental problem .',
  'In order to develop a method of predicting and assessing pond eutrophication , which is a serious environmental problem , and to propose effective measure of improvement of water quality .'],
 'teenage': ['Teenage pregnancy is a socio-economic challenge and a serious public health problem for communities in South Africa .',
  'Unplanned pregnancies among college/tertiary female students pose a serious public health concern in South Africa ( SA ) and are associated with adverse health and social outcomes that impact negatively on educational progress and future career prospects .',
  'Teenage pregnancy rates have declined over the last years but still remains a serious medical and social problem .',
  'Multivariable regression analysis indicated that female pediatricians , adolescent medicine subspecialists , agreeing that pregnancy is a serious problem for adolescents in their practice , and having read the AAP policy statement predicted high knowledge about IUDs as well as Implants for adolescents .',
  'Teenage pregnancy is a serious public health and social problem , with 95 % occurring in developing countries .',
  'Globally , adolescent pregnancy constitutes a serious public health problem of a multifactorial nature .',
  "The rise in teenage pregnancy and young people 's vulnerability to HIV have been a serious problem .",
  '[ Teenage fecundity rates in Chile : a serious public health problem ] .',
  'Background Teenage pregnancies constitute a serious health and social problem worldwide .',
  'Teenage pregnancy has become a serious public health problem , particularly in developing countries with limited obstetric facilities .',
  "Adolescent pregnancy , occurring in girls aged 10 - 19 years , remains a serious health and social problem worldwide , and has been associated with numerous risk factors evident in the young people 's family , peer , school , and neighbourhood contexts .",
  'Sexual relations with intercourse ( ASR-I ) and high prevalence of teen pregnancies ( 19.2 % , in 2002 ) among adolescents in Puerto Rico constitute a serious biopsychosocial problem .',
  'Teen pregnancy . Why it remains a serious social , economic , and educational problem in the U.S.',
  'Pregnancy in adolescence constitutes a serious public health problem at these ages .'],
 'pregnancies': ['Teenage pregnancy is a socio-economic challenge and a serious public health problem for communities in South Africa .',
  'Unplanned pregnancies among college/tertiary female students pose a serious public health concern in South Africa ( SA ) and are associated with adverse health and social outcomes that impact negatively on educational progress and future career prospects .',
  'Teenage pregnancy rates have declined over the last years but still remains a serious medical and social problem .',
  'Multivariable regression analysis indicated that female pediatricians , adolescent medicine subspecialists , agreeing that pregnancy is a serious problem for adolescents in their practice , and having read the AAP policy statement predicted high knowledge about IUDs as well as Implants for adolescents .',
  'Teenage pregnancy is a serious public health and social problem , with 95 % occurring in developing countries .',
  'Globally , adolescent pregnancy constitutes a serious public health problem of a multifactorial nature .',
  "The rise in teenage pregnancy and young people 's vulnerability to HIV have been a serious problem .",
  '[ Teenage fecundity rates in Chile : a serious public health problem ] .',
  'Background Teenage pregnancies constitute a serious health and social problem worldwide .',
  'Teenage pregnancy has become a serious public health problem , particularly in developing countries with limited obstetric facilities .',
  "Adolescent pregnancy , occurring in girls aged 10 - 19 years , remains a serious health and social problem worldwide , and has been associated with numerous risk factors evident in the young people 's family , peer , school , and neighbourhood contexts .",
  'Sexual relations with intercourse ( ASR-I ) and high prevalence of teen pregnancies ( 19.2 % , in 2002 ) among adolescents in Puerto Rico constitute a serious biopsychosocial problem .',
  'Teen pregnancy . Why it remains a serious social , economic , and educational problem in the U.S.',
  'Pregnancy in adolescence constitutes a serious public health problem at these ages .'],
 'denv': ['Recent reports have shown that the dengue virus ( DENV ) is a serious concern worldwide , especially in subtropical areas such as South-East Asia .',
  'Dengue virus ( DENV ) infection remains to be a serious health problem in Indonesia .',
  'Dengue virus ( DENV ) is a serious global health problem .',
  'Dengue virus ( DENV ) , a member of the mosquito-borne flaviviruses , is a serious public health problem in many tropical countries .',
  'Dengue virus ( DV ) is the causal pathogen of dengue fever , which is one of the most rapidly spread mosquito-borne disease worldwide and has become a severe public health problem .',
  'Dengue virus ( DENV ) infection has become a severe public health problem worldwide .',
  'Coinfection produced by dengue virus ( DENV ) and hepatitis C virus ( HCV ) is a serious problem of public health in Mexico , as they both circulate in tropical zones and may lead to masking or complicating symptoms .',
  'Dengue virus ( DENV ) infection has become a public health issue of worldwide concern and is a serious health problem in Taiwan , yet there are no approved effective antiviral drugs to treat DENV .',
  'Dengue represents a serious public health problem worldwide and is caused by infection with dengue virus ( DENV ) .',
  'Dengue virus ( DENV ) infection , which causes dengue fever , dengue hemorrhagic fever , and dengue shock syndrome , is a severe global health problem in tropical and subtropical areas .',
  'Dengue virus ( DENV ) is spread through most tropical and subtropical areas of the world and represents a serious public health problem .'],
 'virus': ['Recent reports have shown that the dengue virus ( DENV ) is a serious concern worldwide , especially in subtropical areas such as South-East Asia .',
  'Dengue virus ( DENV ) infection remains to be a serious health problem in Indonesia .',
  'Dengue virus ( DENV ) is a serious global health problem .',
  'Dengue virus ( DENV ) , a member of the mosquito-borne flaviviruses , is a serious public health problem in many tropical countries .',
  'Dengue virus ( DV ) is the causal pathogen of dengue fever , which is one of the most rapidly spread mosquito-borne disease worldwide and has become a severe public health problem .',
  'Hepatitis E virus ( HEV ) infection is a serious public health concern in developing countries .',
  'Hepatitis E virus ( HEV ) infection is a serious health problem in developing countries and is also increasingly reported in industrialized regions .',
  'The hepatitis E virus causes acute viral hepatitis endemic in much of the developing world and is a serious public health problem .',
  'Dengue virus ( DENV ) infection has become a severe public health problem worldwide .',
  'Coinfection produced by dengue virus ( DENV ) and hepatitis C virus ( HCV ) is a serious problem of public health in Mexico , as they both circulate in tropical zones and may lead to masking or complicating symptoms .',
  'Hepatitis E ( HE ) is a serious problem in developing countries worldwide , affecting in epidemics or as sporadic cases millions of people .',
  'Hepatitis E virus-mediated infection is a serious public health concern in economically developing nations of the world .',
  'Dengue virus ( DENV ) infection has become a public health issue of worldwide concern and is a serious health problem in Taiwan , yet there are no approved effective antiviral drugs to treat DENV .',
  'Hepatitis E caused by hepatitis E virus ( HEV ) is a serious public health concern in developing countries where HEV is mainly transmitted through contaminated water .',
  'Hepatitis E virus ( HEV ) is a serious public health problem that causes acute hepatitis in humans and is primarily transmitted through fecal and oral routes .',
  'Hepatitis E is a serious public health problem in developing countries .',
  'Dengue represents a serious public health problem worldwide and is caused by infection with dengue virus ( DENV ) .',
  'Hepatitis E virus has emerged as a serious problem after solid organ transplantation ( SOT ) , leading to diverse extrahepatic manifestations and chronic hepatitis with unfavorable outcomes .',
  'Dengue virus ( DENV ) infection , which causes dengue fever , dengue hemorrhagic fever , and dengue shock syndrome , is a severe global health problem in tropical and subtropical areas .',
  'Hepatitis E outbreaks are a serious public health concern in developing countries .',
  'Hepatitis E virus ( HEV ) infection is an emerging disease with zoonotic transmission that represents a serious public health concern , especially in developing countries .',
  'Hepatitis E virus ( HEV ) is a serious public health problem .',
  'Dengue virus ( DENV ) is spread through most tropical and subtropical areas of the world and represents a serious public health problem .'],
 'copd': ['Chronic obstructive pulmonary disease ( COPD ) is a disease caused by cigarette smoke , which has been emerging as a serious health problem worldwide .',
  'Chronic obstructive pulmonary disease ( COPD ) is a serious public health problem in our country .',
  'Chronic obstructive pulmonary disease ( COPD ) is a serious health problem .',
  'Chronic obstructive pulmonary disease ( COPD ) represents a serious global health problem that affects the aged .',
  'Chronic obstructive pulmonary disease ( COPD ) is a serious health problem that has significant effects on the life status of elderly persons .',
  'COPD is one of the most common causes of death globally and it is still a serious public health problem worldwide .',
  'Despite the wide use of PCV2 vaccination , PRDC remains a serious respiratory problem .',
  'The steady increase in incidence of chronic respiratory disease ( CRD ) now constitutes a serious public health problem .',
  'Chronic obstructive pulmonary disease ( COPD ) and its consequences in terms of disability and mortality are , in current practice , a serious public health problem whose prevalence is unknown in Algeria .',
  'Although there has been a slight reduction in mortality in recent decades , COPD is still a serious health problem that has enormous costs and utilizes significant medical resources .',
  'Chronic obstructive pulmonary disease ( COPD ) is a serious and mounting global public health problem .',
  'The alarming rate of mortality and disability due to Chronic Obstructive Pulmonary Disease ( COPD ) has become a serious health concern worldwide .',
  'Chronic obstructive pulmonary disease ( COPD ) , characterized by chronic airflow limitation , is a serious public health concern .',
  'Chronic obstructive pulmonary disease ( COPD ) is a serious public health problem .',
  'Introduction : Chronic obstructive pulmonary disease ( COPD ) is the main cause of progression chronic pulmonary heart ( CPH ) , it is a serious worldwide problem .',
  'Chronic obstructive pulmonary disease ( COPD ) remains a severe public health problem .',
  'COPD has become a serious public-health concern .',
  'Chronic obstructive pulmonary disease ( COPD ) still remains a serious public health problem , which is a common cause of disability and death in the able-bodied population .'],
 'pulmonary': ['Chronic obstructive pulmonary disease ( COPD ) is a disease caused by cigarette smoke , which has been emerging as a serious health problem worldwide .',
  'Pulmonary embolism is also a serious problem that occurs in more than 500,000patients per year , of whom approximately 200,000will die .',
  'Pulmonary embolism is a serious and difficult problem .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem and computed tomography pulmonary angiography ( CTPA ) is the gold standard for diagnosis .',
  'Computed tomography pulmonary angiography ( CTPA ) is the standard imaging modality for detection or rule out of pulmonary embolism ( PE ) ; however , radiation exposure is a serious concern .',
  'Chronic obstructive pulmonary disease ( COPD ) is a serious public health problem in our country .',
  'Idiopathic pulmonary fibrosis ( IPF ) is a fatal growing problem , with limited therapeutic options .',
  'Pulmonary fibrosis is a vexing clinical problem with no proven therapeutic options .',
  'Fibrosis is also a serious cosmetic problem for patients , and in some cases it can also imply pain .',
  'Chronic obstructive pulmonary disease ( COPD ) is a serious health problem .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem , and computed tomographic imaging is the standard for diagnosis .',
  'Chronic obstructive pulmonary disease ( COPD ) represents a serious global health problem that affects the aged .',
  'Chronic obstructive pulmonary disease ( COPD ) is a serious health problem that has significant effects on the life status of elderly persons .',
  'COPD is one of the most common causes of death globally and it is still a serious public health problem worldwide .',
  'Pulmonary fibrosis is a progressively aggravating lethal disease that is a serious public health concern .',
  'Drug-induced interstitial lung disease ( ILD ) , particularly pulmonary fibrosis , is a serious clinical concern and myofibroblasts have been suggested to have a major role , with it recently being revealed that some of these myofibroblasts are derived from lung epithelial cells through epithelial-mesenchymal transition ( EMT ) .',
  'Despite the wide use of PCV2 vaccination , PRDC remains a serious respiratory problem .',
  'The steady increase in incidence of chronic respiratory disease ( CRD ) now constitutes a serious public health problem .',
  'Chronic obstructive pulmonary disease ( COPD ) and its consequences in terms of disability and mortality are , in current practice , a serious public health problem whose prevalence is unknown in Algeria .',
  'Septic pulmonary embolism is a serious but uncommon syndrome posing diagnostic challenges because of its broad range of clinical presentation and etiologies .',
  'Fibrosis is a serious health problem often leading to accompanying organ failure .',
  'The Pulmonary Embolism Response Team ( PERT ) is a multidisciplinary team that quickly evaluates , coordinates diagnosis , and optimizes management for patients with pulmonary embolism ( PE ) , a serious public health problem .',
  'Diagnosis and management of the patient with pulmonary embolism remains a vexing clinical problem .',
  'Although there has been a slight reduction in mortality in recent decades , COPD is still a serious health problem that has enormous costs and utilizes significant medical resources .',
  'Chronic obstructive pulmonary disease ( COPD ) is a serious and mounting global public health problem .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem and computed tomography pulmonary angiography ( CTPA ) is the gold standard for diagnosis .',
  'The alarming rate of mortality and disability due to Chronic Obstructive Pulmonary Disease ( COPD ) has become a serious health concern worldwide .',
  'The results suggested that chronic airway inflammation in ICS is not such a serious problem compared with DPB and BE .',
  'Chronic obstructive pulmonary disease ( COPD ) , characterized by chronic airflow limitation , is a serious public health concern .',
  'Multi-cause-induced interstitial lung disease , particularly pulmonary fibrosis , is a serious clinical concern .',
  'Idiopathic pulmonary fibrosis ( IPF ) is a serious lung problem with advancing and diffusive pulmonary fibrosis as the pathologic basis , and with oxidative stress and inflammation as the key pathogenesis .',
  'Chronic obstructive pulmonary disease ( COPD ) is a serious public health problem .',
  'Introduction : Chronic obstructive pulmonary disease ( COPD ) is the main cause of progression chronic pulmonary heart ( CPH ) , it is a serious worldwide problem .',
  'Chronic obstructive pulmonary disease ( COPD ) remains a severe public health problem .',
  'Pulmonary fibrosis remains a serious biomedical problem with no cure and an urgent need for better therapies .',
  'Fibrosis is a severe and progressive sequel of many pulmonary diseases , has no effective therapy at present and , consequently , represents a serious health problem .',
  'COPD has become a serious public-health concern .',
  'Although massive pulmonary tumor embolism occurs relatively rarely , it can be a catastrophic problem .',
  'Chronic obstructive pulmonary disease ( COPD ) still remains a serious public health problem , which is a common cause of disability and death in the able-bodied population .'],
 'chagas': ["Accidental transmission of Chagas ' disease to man by blood transfusion is a serious problem in Latin-America .",
  'Chagas disease remains a serious public health concern with unsatisfactory treatment outcomes due to strain-specific drug resistance and various side effects .',
  "Chagas ' disease is a severe health problem , mainly in Latin America , causing approximately 50000 deaths a year and millions of people are infected .",
  'Afflicting approximately 8 million people in Latin America , Chagas disease is now becoming a serious global health problem proliferating beyond the traditional geographical borders , mainly because of human and vector migration .',
  'These results suggest that the decrease in poverty that has occurred in Bolivia between both surveys might have contributed to reduce the morbidity and mortality , but not the transmission rate of T. cruzi congenital infection , which remains a serious public health problem in this country .',
  'Although a decrease in Chagas mortality has occurred in Brazil , the disease remains a serious public health problem , especially in the Northeast region .',
  'Chagas disease is a serious social-medical problem in Latin American countries because of its high incidence , morbidity and mortality .',
  'Chagas disease remains a severe public health problem in Latin America , despite control over its transmission .',
  "Chagas ' disease is a serious health problem for the population of South and Central America .",
  'Chagas disease ( CD ) still represents a serious public health problem in Latin America , even after more than 100 years of its discovery .',
  'Chagas disease remains a serious public health problem in several Latin American countries .',
  'Chagas disease ( CD ) is a serious public health problem in Latin America and its treatment remains neglected .',
  'However Chagas disease is still a serious problem , especially for numerous middle-aged infected adults .',
  'Chagas disease continues to be a serious public health problem , and accounts for 25 - 30 % of the indications for cardiac stimulation in Brazil .',
  "Transfusion-associated Chagas ' disease is a serious public health problem in Central and South America .",
  'Chagas disease remains a serious medical and social problem in Latin America and is an emerging concern in nonendemic countries as a result of population movement , transfusion of infected blood or organs and congenital transmission .',
  'Chagas disease represents a serious problem in public health .',
  'Chagas disease is a parasitosis considered a serious problem of public health .',
  'Chagas disease remains a serious health problem for countries where the most common mode of transmission is infection contracted from the feces of a Triatominae insect vector .',
  'Chagas disease , amebiasis , giardiasis and trichomoniasis represent a serious health problem in Latin America .',
  'Chagas disease represents a serious public health problem in South America .',
  'In Honduras , where Chagas disease is a serious health and environmental concern , prevention measures face the challenge of achieving widespread and long-term sustainable adoption by communities .',
  "Chagas ' disease is a serious public health problem in Paraguay , however , the immunoepidemiology of the disease has not been well documented .",
  'In Venezuela , Chagas disease ( ChD ) is considered a serious health problem , with about 6 million people at risk ; and acute outbreaks due to oral transmission of Chagas Disease ( OChD ) are becoming increasingly important .',
  "Despite the decline of mortality associated with Chagas ' disease in Brazil , the disease remains a serious public health problem with marked regional differences .",
  'Endemic in Latin America , Chagas disease is now becoming a serious global health problem , and yet has no financial viability for the pharmaceutical industry and remains incurable .',
  "Despite all efforts to restrict its transmission , Chagas ' disease remains a severe public health problem in Latin America , affecting 8 - 12 million individuals .",
  'Chagas disease is a serious health problem for Latin America .',
  "Chagas ' disease is a serious public health problem in Latin America , and no treatment is available for the prevalent chronic stage .",
  'Chagas disease is a serious health problem in Latin America .',
  'Chagas disease remains a serious health problem in large parts of Mexico and Central and South America , where it is a major cause of morbidity and mortality .',
  'Accidental transmission of Chagas disease to man by blood transfusion is a serious problem in Latin America .'],
 'genes': ['Antibiotic resistance genes ( ARGs ) in the environment and their subsequent acquisition by clinically important microorganisms are a serious concern .',
  'Antibiotic contaminants have become a severe environmental problem in recent years and finding effective ways to deal with this issue is of great importance .',
  'Presence of E. coli strains expressing co-resistance to both these antibiotic classes in urban aquatic environments which are consistently being used for various anthropogenic activities represents a serious public health concern .',
  'The occurrence of antibiotics in wastewater has become a serious concern due to the possible development of antibiotic resistant bacteria in wastewater treatment process .',
  'The presence of antimicrobial-resistant bacteria and resistance genes in aquatic environments is a serious public health concern .',
  'The emergence and prevalence of antibiotic resistance genes ( ARGs ) in the environment is a serious global health concern .',
  'The spread of antibiotic resistance genes ( ARGs ) in the environment is a serious concern .',
  'Excessive use of antibiotics in aquatic products is a serious problem for food safety and human health , and on-site detection of antibiotics is highly demanded .',
  'The presence of multiple-antibiotic-resistant bacteria from effluents of WWTPs into natural waters could pose a serious problem as a secondary pollutant of drinking water .',
  'The spread of ARGs among pathogenic bacteria currently constitutes a serious global health problem .',
  'Antibiotic resistance genes ( ARGs ) in urban rivers are a serious public health concern in regions with poorly planned , rapid development .',
  'Functional analysis showed a high representation of genes in the KEGG pathway involved in the metabolism of amino acids and carbohydrates and identified several genes associated with antibiotic resistance and xenobiotic degradation in these environments , which can be a serious problem for human health and environment .',
  'Antibiotic resistant bacteria ( ARB ) and antibiotic resistance genes ( ARGs ) are the emerging contaminants leading to a serious worldwide health problem .',
  'Antibiotic contamination in environmental matrices is a serious global problem which leads to an increase in the proliferation of antibiotic resistance genes .',
  'This study was performed to investigate the mineralization of ticarcillin in the artificially prepared aqueous solution presenting ticarcillin contaminated waters , which constitute a serious problem for human health .',
  'The emergence and increased prevalence of antibiotic resistance genes ( ARGs ) in the environment may pose a serious global health concern .',
  'An overview of cephalosporin antibiotics as emerging contaminants : a serious environmental concern .',
  'The disposal and utilization of antibiotic mycelial dreg ( AMD ) , which has been identified as a hazardous waste in China , are a serious concern because of the residual antibiotic and huge annual output .',
  'Trace levels of residual antibiotics in drinking water may threaten public health and become a serious problem in modern society .',
  'Sulfonamide residue in foodstuffs and the environment is a serious global concern for their contribution to the occurrence of antibiotic-resistant bacteria , especially in developing countries .',
  'The emergence and prevalence of antibiotic resistance genes ( ARGs ) in the environment is a serious global health concern .',
  'The occurrence of antibiotics in drinking water has become a serious problem worldwide as they are a potential and real threat to human health .',
  'Release of emerging pollutants including antibiotics to the environment is a serious concern for environmentalist as well as policy makers .',
  'Antibiotic-resistant bacteria have become a serious problem worldwide , caused in part by the excessive use and discharge of antibiotics into the environment .',
  'The presence of antibiotics in the aquatic environment is a serious concern because it may lead to the emergence of antibiotic resistance , thus lowering the therapeutic effect of antibiotics .',
  'Antibiotics are widely used , and there is a serious concern about its adverse impacts on the environment and human health .'],
 'antibiotic': ['Antibiotic resistance genes ( ARGs ) in the environment and their subsequent acquisition by clinically important microorganisms are a serious concern .',
  'Antibiotic contaminants have become a severe environmental problem in recent years and finding effective ways to deal with this issue is of great importance .',
  'Presence of E. coli strains expressing co-resistance to both these antibiotic classes in urban aquatic environments which are consistently being used for various anthropogenic activities represents a serious public health concern .',
  'The occurrence of antibiotics in wastewater has become a serious concern due to the possible development of antibiotic resistant bacteria in wastewater treatment process .',
  'The presence of antimicrobial-resistant bacteria and resistance genes in aquatic environments is a serious public health concern .',
  'The emergence and prevalence of antibiotic resistance genes ( ARGs ) in the environment is a serious global health concern .',
  'The spread of antibiotic resistance genes ( ARGs ) in the environment is a serious concern .',
  'Excessive use of antibiotics in aquatic products is a serious problem for food safety and human health , and on-site detection of antibiotics is highly demanded .',
  'The presence of multiple-antibiotic-resistant bacteria from effluents of WWTPs into natural waters could pose a serious problem as a secondary pollutant of drinking water .',
  'The spread of ARGs among pathogenic bacteria currently constitutes a serious global health problem .',
  'Antibiotic resistance genes ( ARGs ) in urban rivers are a serious public health concern in regions with poorly planned , rapid development .',
  'Functional analysis showed a high representation of genes in the KEGG pathway involved in the metabolism of amino acids and carbohydrates and identified several genes associated with antibiotic resistance and xenobiotic degradation in these environments , which can be a serious problem for human health and environment .',
  'Antibiotic resistant bacteria ( ARB ) and antibiotic resistance genes ( ARGs ) are the emerging contaminants leading to a serious worldwide health problem .',
  'Antibiotic contamination in environmental matrices is a serious global problem which leads to an increase in the proliferation of antibiotic resistance genes .',
  'This study was performed to investigate the mineralization of ticarcillin in the artificially prepared aqueous solution presenting ticarcillin contaminated waters , which constitute a serious problem for human health .',
  'The emergence and increased prevalence of antibiotic resistance genes ( ARGs ) in the environment may pose a serious global health concern .',
  'An overview of cephalosporin antibiotics as emerging contaminants : a serious environmental concern .',
  'The disposal and utilization of antibiotic mycelial dreg ( AMD ) , which has been identified as a hazardous waste in China , are a serious concern because of the residual antibiotic and huge annual output .',
  'Trace levels of residual antibiotics in drinking water may threaten public health and become a serious problem in modern society .',
  'Sulfonamide residue in foodstuffs and the environment is a serious global concern for their contribution to the occurrence of antibiotic-resistant bacteria , especially in developing countries .',
  'The emergence and prevalence of antibiotic resistance genes ( ARGs ) in the environment is a serious global health concern .',
  'The occurrence of antibiotics in drinking water has become a serious problem worldwide as they are a potential and real threat to human health .',
  'Release of emerging pollutants including antibiotics to the environment is a serious concern for environmentalist as well as policy makers .',
  'Antibiotic-resistant bacteria have become a serious problem worldwide , caused in part by the excessive use and discharge of antibiotics into the environment .',
  'The presence of antibiotics in the aquatic environment is a serious concern because it may lead to the emergence of antibiotic resistance , thus lowering the therapeutic effect of antibiotics .',
  'Antibiotics are widely used , and there is a serious concern about its adverse impacts on the environment and human health .'],
 'blooms': ['Harmful algal blooms ( HABs ) induced by eutrophication is becoming a serious global environmental problem affecting public health and aquatic ecological sustainability .',
  'The toxic cyanobacteria are a serious problem for water supply systems , recreation , and agriculture .',
  'The microcystins produced by cyanobacteria pose a serious problem to human health , if they contaminate drinking water or food .',
  'Harmful algal blooms , caused by massive and exceptional overgrowth of microalgae and cyanobacteria , are a serious environmental problem worldwide : In the present study , we looked for Bacillus strains with sufficiently strong anticyanobacterial activity to be used as biocontrol agents .',
  'In the Mediterranean Sea , periodic summer blooms have been reported and have become a serious concern due to their direct impact on human health and the environment .',
  'The eutrophication of aquatic ecosystems is a serious environmental problem that leads to increased frequency of cyanobacterial blooms and concentrations of cyanotoxins .',
  'Cyanobacterial blooms have become a serious problem in Lake Taihu during the last 20 years , and Microcystis aeruginosa and Synechococcus sp. are the two dominant species in cyanobacterial blooms of Lake Taihu .',
  'The prevalence of cyanobacterial blooms in fresh water bodies worldwide has become a serious environmental problem .',
  'Epiphytic filamentous algae ( EFA ) were noted as a serious problem to reduce the production and quality of K. alvarezii .',
  'This toxin is able to bioaccumulate in freshwater food webs , representing a serious human health problem .',
  'Harmful cyanobacterial bloom ( HCB ) by Microcystis aeruginosa is increasingly becoming a serious concern to the environment and human health alike .',
  'In recent years , the water pollution of cyanobacteria blooms has become a severe problem in this area .',
  'Green tide , which is a serious water pollution problem , is caused by the complex relationships of various factors , such as flow rate , several water quality indicators , and weather .',
  'Ciguatera fish poisoning ( CFP ) is a serious health problem in tropical regions and is caused by the bioaccumulation of lipophilic toxins produced by dinoflagellates in the genus Gambierdiscus .',
  'The presence of Ostreopsis cf . ovata on the Mediterranean coast represents a serious concern to human health due to production of toxins - putative palytoxin and ovatoxins ( ovatoxin-a , -b , -c , -d , -e , -f and -g ) .',
  'This phytoplankton is known to produce palytoxin-like compounds , listed among the most potent marine toxins known , and can pose a serious concern for humans in the Mediterranean area .',
  'Cyanobacteria and cyanotoxins constitute a serious environmental and human health problem .',
  'Once in the environment , A. baumannii is able to survive regardless of the availability of dissolved oxygen , which represents a serious public health concern .',
  'Excessive cyanobacterial growth in eutrophic water sources has been a serious environmental problem , and both sight preservation and drinking water production demand control of cyanobacterial growth in water .',
  'Harmful algal blooms ( HABs ) are a serious environmental problem globally .',
  'Because of the production of toxins such as Cylindrospermopsin ( CYN ) , contamination of water with cyanobacteria is a serious health problem around the world .',
  'Currently , the benthic dinoflagellate Ostreopsis cf . ovata represents a serious concern to human health in the whole Mediterranean basin due to the production of palytoxin congeners , a putative palytoxin and ovatoxins ( ovatoxin-a , -b , -c , -d/-e ) , listed among the most potent marine toxins .',
  'In particular , the presence of cyanobacteria toxins , especially microcystins ( MCs ) , has become a severe problem .',
  'Microcystin-producing Microcystis bloom is a severe water problem in the world .',
  'The HABs outbreak , often linked with anthropogenic eutrophication , has become a serious environmental health problem that threats our communities .',
  'The presence of the toxin cylindrospermopsin is increasingly frequent in samples from different ecosystems and it is a serious problem both at environmental level and for animal and human health .',
  'These blooms are often toxic and have become a serious health problem .',
  'The occurrence of harmful algal bloom in water source poses a serious water safety problem to local water supply systems .',
  'Cyanogenic potential ( CNp ) of cassava constitutes a serious problem for over 500 million people who rely on the crop as their main source of calories .',
  "Ulva prolifera green tide is a serious marine ecological problem in China 's coastal areas , with recurrent outbreaks occurring annually during late spring and summer since 2007 .",
  'Blooms of benthic dinoflagellates of the genus Ostreopsis ( mainly O. cf . ovata and occasionally O. cf . siamensis ) represent a serious concern for humans in the Mediterranean area , due to production of palytoxin-like compounds listed among the most potent marine toxins known .',
  'Contamination of water by cyanobacteria ( blue-green algae ) is a serious health problem around the world , largely due to the toxic effects of microcystins , a group of potent hepatotoxins .',
  'Harmful algal blooms ( HABs ) has been a serious problem in recent years , because of large quantities of cyanobacterial in eutrophic water .',
  'In fjord systems , Harmful Algal Blooms ( HABs ) not only constitute a serious problem when affecting the wildlife and ecosystems , but also human health and economic activities related to the marine environment .',
  'The development of mucilaginous cyanobacterial Microcystis blooms is a serious environmental and ecological problem , and information on the bloom-formation mechanism has been lacking until now .',
  'The increasing cyanobacterial blooms have recently been considered a severe environmental problem .',
  'The release of toxic hydrogen cyanide ( HCN ) from endogenous CNglcs , which is known as cyanogenesis , leads to a serious problem for animal consumption while as defensive secondary metabolites , CNglcs play multiple roles in plant development and responses to adverse environment .',
  'Taste and odor pollution caused by secondary metabolites from cyanobacterial blooms has become a serious and widespread environmental problem .',
  'Each year there are more frequent blooms of green algae and cyanobacteria , representing a serious environmental problem of eutrophication .',
  'In recent years cyanobacteria blooms have become a severe problem in Taihu Lake , a large shallow eutrophic lake in China .',
  'Contamination of water on toxic blooms of cyanobacteria has occurred in many regions of the world and could be a serious public health problem .',
  'The limited availability of commercially available standards for azaspiracids is a serious problem , because validated LC-MS methods are required for routine analysis of these toxins in shellfish tissues .',
  'Algal pollution in water sources has posed a serious problem .',
  'Contamination of water , foods and food supplements by various genera of cyanobacteria is a serious health problem worldwide for humans and animals , largely due to the toxic effects of microcystins ( MCs ) and nodularin ( NOD ) , a group of hepatotoxic cyclic peptides .',
  'Algal blooms are a serious problem in waters , which damage aquatic ecosystems and threaten drinking water safety .',
  'To explore the potential reporter gene assay for the detection of sodium channel-specific toxins in shellfish as an alternative for screening harmful algal bloom ( HAB ) toxins , considering the fact that the existing methods including HPLC and bioassay are inappropriate for identifying HAB toxins which poses a serious problem on human health and shellfish industry .',
  'Lipophilic marine toxins pose a serious threat for consumers and an enormous economic problem for shellfish producers .',
  'Cyanobacterial blooms are a frequent occurrence in northeastern Brazil and constitute a serious public health problem .',
  'Blooms of cyanobacteria , produced mainly as result of the pollution of water bodies with excessive amounts of phosphorus , represent a severe environmental problem ; not only do they affect the normal equilibrium of the aquatic ecosystem but may also affect animal and human health .',
  'However , algal blooms in urban rivers located downstream of eutrophicated lakes are also a serious problem for local administrators .',
  'Toxic cyanobacteria ( blue-green algae ) water blooms have become a serious problem in several industrialized areas of the world .',
  'The contamination of shellfish with marine biotoxins derived from microalgae represents a serious problem for shellfish industries and public health .',
  'Black blooms are a serious and complex problem for lake bays , with far-reaching implications for water quality and drinking safety .',
  'Algal bloom ( AB ) is a serious water environment problem in China , but it is still unclear how AB affects microorganisms with special functions ( such as nitrogen- , phosphorus- , sulfur- and iron-related bacteria ) at different AB stages .',
  'Toxic cyanobacteria represent a serious health and ecological problem in drinking and recreational waters worldwide .'],
 'cyanobacteria': ['Harmful algal blooms ( HABs ) induced by eutrophication is becoming a serious global environmental problem affecting public health and aquatic ecological sustainability .',
  'The toxic cyanobacteria are a serious problem for water supply systems , recreation , and agriculture .',
  'The microcystins produced by cyanobacteria pose a serious problem to human health , if they contaminate drinking water or food .',
  'Harmful algal blooms , caused by massive and exceptional overgrowth of microalgae and cyanobacteria , are a serious environmental problem worldwide : In the present study , we looked for Bacillus strains with sufficiently strong anticyanobacterial activity to be used as biocontrol agents .',
  'In the Mediterranean Sea , periodic summer blooms have been reported and have become a serious concern due to their direct impact on human health and the environment .',
  'The eutrophication of aquatic ecosystems is a serious environmental problem that leads to increased frequency of cyanobacterial blooms and concentrations of cyanotoxins .',
  'Cyanobacterial blooms have become a serious problem in Lake Taihu during the last 20 years , and Microcystis aeruginosa and Synechococcus sp. are the two dominant species in cyanobacterial blooms of Lake Taihu .',
  'The prevalence of cyanobacterial blooms in fresh water bodies worldwide has become a serious environmental problem .',
  'Epiphytic filamentous algae ( EFA ) were noted as a serious problem to reduce the production and quality of K. alvarezii .',
  'This toxin is able to bioaccumulate in freshwater food webs , representing a serious human health problem .',
  'Harmful cyanobacterial bloom ( HCB ) by Microcystis aeruginosa is increasingly becoming a serious concern to the environment and human health alike .',
  'In recent years , the water pollution of cyanobacteria blooms has become a severe problem in this area .',
  'Green tide , which is a serious water pollution problem , is caused by the complex relationships of various factors , such as flow rate , several water quality indicators , and weather .',
  'Ciguatera fish poisoning ( CFP ) is a serious health problem in tropical regions and is caused by the bioaccumulation of lipophilic toxins produced by dinoflagellates in the genus Gambierdiscus .',
  'The presence of Ostreopsis cf . ovata on the Mediterranean coast represents a serious concern to human health due to production of toxins - putative palytoxin and ovatoxins ( ovatoxin-a , -b , -c , -d , -e , -f and -g ) .',
  'This phytoplankton is known to produce palytoxin-like compounds , listed among the most potent marine toxins known , and can pose a serious concern for humans in the Mediterranean area .',
  'Cyanobacteria and cyanotoxins constitute a serious environmental and human health problem .',
  'Once in the environment , A. baumannii is able to survive regardless of the availability of dissolved oxygen , which represents a serious public health concern .',
  'Excessive cyanobacterial growth in eutrophic water sources has been a serious environmental problem , and both sight preservation and drinking water production demand control of cyanobacterial growth in water .',
  'Harmful algal blooms ( HABs ) are a serious environmental problem globally .',
  'Because of the production of toxins such as Cylindrospermopsin ( CYN ) , contamination of water with cyanobacteria is a serious health problem around the world .',
  'Currently , the benthic dinoflagellate Ostreopsis cf . ovata represents a serious concern to human health in the whole Mediterranean basin due to the production of palytoxin congeners , a putative palytoxin and ovatoxins ( ovatoxin-a , -b , -c , -d/-e ) , listed among the most potent marine toxins .',
  'In particular , the presence of cyanobacteria toxins , especially microcystins ( MCs ) , has become a severe problem .',
  'Microcystin-producing Microcystis bloom is a severe water problem in the world .',
  'The HABs outbreak , often linked with anthropogenic eutrophication , has become a serious environmental health problem that threats our communities .',
  'The presence of the toxin cylindrospermopsin is increasingly frequent in samples from different ecosystems and it is a serious problem both at environmental level and for animal and human health .',
  'These blooms are often toxic and have become a serious health problem .',
  'The occurrence of harmful algal bloom in water source poses a serious water safety problem to local water supply systems .',
  'Cyanogenic potential ( CNp ) of cassava constitutes a serious problem for over 500 million people who rely on the crop as their main source of calories .',
  "Ulva prolifera green tide is a serious marine ecological problem in China 's coastal areas , with recurrent outbreaks occurring annually during late spring and summer since 2007 .",
  'Blooms of benthic dinoflagellates of the genus Ostreopsis ( mainly O. cf . ovata and occasionally O. cf . siamensis ) represent a serious concern for humans in the Mediterranean area , due to production of palytoxin-like compounds listed among the most potent marine toxins known .',
  'Contamination of water by cyanobacteria ( blue-green algae ) is a serious health problem around the world , largely due to the toxic effects of microcystins , a group of potent hepatotoxins .',
  'Harmful algal blooms ( HABs ) has been a serious problem in recent years , because of large quantities of cyanobacterial in eutrophic water .',
  'In fjord systems , Harmful Algal Blooms ( HABs ) not only constitute a serious problem when affecting the wildlife and ecosystems , but also human health and economic activities related to the marine environment .',
  'The development of mucilaginous cyanobacterial Microcystis blooms is a serious environmental and ecological problem , and information on the bloom-formation mechanism has been lacking until now .',
  'The increasing cyanobacterial blooms have recently been considered a severe environmental problem .',
  'The release of toxic hydrogen cyanide ( HCN ) from endogenous CNglcs , which is known as cyanogenesis , leads to a serious problem for animal consumption while as defensive secondary metabolites , CNglcs play multiple roles in plant development and responses to adverse environment .',
  'Taste and odor pollution caused by secondary metabolites from cyanobacterial blooms has become a serious and widespread environmental problem .',
  'Each year there are more frequent blooms of green algae and cyanobacteria , representing a serious environmental problem of eutrophication .',
  'In recent years cyanobacteria blooms have become a severe problem in Taihu Lake , a large shallow eutrophic lake in China .',
  'Contamination of water on toxic blooms of cyanobacteria has occurred in many regions of the world and could be a serious public health problem .',
  'The limited availability of commercially available standards for azaspiracids is a serious problem , because validated LC-MS methods are required for routine analysis of these toxins in shellfish tissues .',
  'Algal pollution in water sources has posed a serious problem .',
  'Contamination of water , foods and food supplements by various genera of cyanobacteria is a serious health problem worldwide for humans and animals , largely due to the toxic effects of microcystins ( MCs ) and nodularin ( NOD ) , a group of hepatotoxic cyclic peptides .',
  'Algal blooms are a serious problem in waters , which damage aquatic ecosystems and threaten drinking water safety .',
  'To explore the potential reporter gene assay for the detection of sodium channel-specific toxins in shellfish as an alternative for screening harmful algal bloom ( HAB ) toxins , considering the fact that the existing methods including HPLC and bioassay are inappropriate for identifying HAB toxins which poses a serious problem on human health and shellfish industry .',
  'Lipophilic marine toxins pose a serious threat for consumers and an enormous economic problem for shellfish producers .',
  'Cyanobacterial blooms are a frequent occurrence in northeastern Brazil and constitute a serious public health problem .',
  'Blooms of cyanobacteria , produced mainly as result of the pollution of water bodies with excessive amounts of phosphorus , represent a severe environmental problem ; not only do they affect the normal equilibrium of the aquatic ecosystem but may also affect animal and human health .',
  'However , algal blooms in urban rivers located downstream of eutrophicated lakes are also a serious problem for local administrators .',
  'Toxic cyanobacteria ( blue-green algae ) water blooms have become a serious problem in several industrialized areas of the world .',
  'The contamination of shellfish with marine biotoxins derived from microalgae represents a serious problem for shellfish industries and public health .',
  'Black blooms are a serious and complex problem for lake bays , with far-reaching implications for water quality and drinking safety .',
  'Algal bloom ( AB ) is a serious water environment problem in China , but it is still unclear how AB affects microorganisms with special functions ( such as nitrogen- , phosphorus- , sulfur- and iron-related bacteria ) at different AB stages .',
  'Toxic cyanobacteria represent a serious health and ecological problem in drinking and recreational waters worldwide .'],
 'cyanobacterial': ['Harmful algal blooms ( HABs ) induced by eutrophication is becoming a serious global environmental problem affecting public health and aquatic ecological sustainability .',
  'The toxic cyanobacteria are a serious problem for water supply systems , recreation , and agriculture .',
  'The microcystins produced by cyanobacteria pose a serious problem to human health , if they contaminate drinking water or food .',
  'Harmful algal blooms , caused by massive and exceptional overgrowth of microalgae and cyanobacteria , are a serious environmental problem worldwide : In the present study , we looked for Bacillus strains with sufficiently strong anticyanobacterial activity to be used as biocontrol agents .',
  'In the Mediterranean Sea , periodic summer blooms have been reported and have become a serious concern due to their direct impact on human health and the environment .',
  'The eutrophication of aquatic ecosystems is a serious environmental problem that leads to increased frequency of cyanobacterial blooms and concentrations of cyanotoxins .',
  'Cyanobacterial blooms have become a serious problem in Lake Taihu during the last 20 years , and Microcystis aeruginosa and Synechococcus sp. are the two dominant species in cyanobacterial blooms of Lake Taihu .',
  'The prevalence of cyanobacterial blooms in fresh water bodies worldwide has become a serious environmental problem .',
  'Epiphytic filamentous algae ( EFA ) were noted as a serious problem to reduce the production and quality of K. alvarezii .',
  'This toxin is able to bioaccumulate in freshwater food webs , representing a serious human health problem .',
  'Harmful cyanobacterial bloom ( HCB ) by Microcystis aeruginosa is increasingly becoming a serious concern to the environment and human health alike .',
  'In recent years , the water pollution of cyanobacteria blooms has become a severe problem in this area .',
  'Green tide , which is a serious water pollution problem , is caused by the complex relationships of various factors , such as flow rate , several water quality indicators , and weather .',
  'Ciguatera fish poisoning ( CFP ) is a serious health problem in tropical regions and is caused by the bioaccumulation of lipophilic toxins produced by dinoflagellates in the genus Gambierdiscus .',
  'The presence of Ostreopsis cf . ovata on the Mediterranean coast represents a serious concern to human health due to production of toxins - putative palytoxin and ovatoxins ( ovatoxin-a , -b , -c , -d , -e , -f and -g ) .',
  'This phytoplankton is known to produce palytoxin-like compounds , listed among the most potent marine toxins known , and can pose a serious concern for humans in the Mediterranean area .',
  'Cyanobacteria and cyanotoxins constitute a serious environmental and human health problem .',
  'Once in the environment , A. baumannii is able to survive regardless of the availability of dissolved oxygen , which represents a serious public health concern .',
  'Excessive cyanobacterial growth in eutrophic water sources has been a serious environmental problem , and both sight preservation and drinking water production demand control of cyanobacterial growth in water .',
  'Harmful algal blooms ( HABs ) are a serious environmental problem globally .',
  'Because of the production of toxins such as Cylindrospermopsin ( CYN ) , contamination of water with cyanobacteria is a serious health problem around the world .',
  'Currently , the benthic dinoflagellate Ostreopsis cf . ovata represents a serious concern to human health in the whole Mediterranean basin due to the production of palytoxin congeners , a putative palytoxin and ovatoxins ( ovatoxin-a , -b , -c , -d/-e ) , listed among the most potent marine toxins .',
  'In particular , the presence of cyanobacteria toxins , especially microcystins ( MCs ) , has become a severe problem .',
  'Microcystin-producing Microcystis bloom is a severe water problem in the world .',
  'The HABs outbreak , often linked with anthropogenic eutrophication , has become a serious environmental health problem that threats our communities .',
  'The presence of the toxin cylindrospermopsin is increasingly frequent in samples from different ecosystems and it is a serious problem both at environmental level and for animal and human health .',
  'These blooms are often toxic and have become a serious health problem .',
  'The occurrence of harmful algal bloom in water source poses a serious water safety problem to local water supply systems .',
  'Cyanogenic potential ( CNp ) of cassava constitutes a serious problem for over 500 million people who rely on the crop as their main source of calories .',
  "Ulva prolifera green tide is a serious marine ecological problem in China 's coastal areas , with recurrent outbreaks occurring annually during late spring and summer since 2007 .",
  'Blooms of benthic dinoflagellates of the genus Ostreopsis ( mainly O. cf . ovata and occasionally O. cf . siamensis ) represent a serious concern for humans in the Mediterranean area , due to production of palytoxin-like compounds listed among the most potent marine toxins known .',
  'Contamination of water by cyanobacteria ( blue-green algae ) is a serious health problem around the world , largely due to the toxic effects of microcystins , a group of potent hepatotoxins .',
  'Harmful algal blooms ( HABs ) has been a serious problem in recent years , because of large quantities of cyanobacterial in eutrophic water .',
  'In fjord systems , Harmful Algal Blooms ( HABs ) not only constitute a serious problem when affecting the wildlife and ecosystems , but also human health and economic activities related to the marine environment .',
  'The development of mucilaginous cyanobacterial Microcystis blooms is a serious environmental and ecological problem , and information on the bloom-formation mechanism has been lacking until now .',
  'The increasing cyanobacterial blooms have recently been considered a severe environmental problem .',
  'The release of toxic hydrogen cyanide ( HCN ) from endogenous CNglcs , which is known as cyanogenesis , leads to a serious problem for animal consumption while as defensive secondary metabolites , CNglcs play multiple roles in plant development and responses to adverse environment .',
  'Taste and odor pollution caused by secondary metabolites from cyanobacterial blooms has become a serious and widespread environmental problem .',
  'Each year there are more frequent blooms of green algae and cyanobacteria , representing a serious environmental problem of eutrophication .',
  'In recent years cyanobacteria blooms have become a severe problem in Taihu Lake , a large shallow eutrophic lake in China .',
  'Contamination of water on toxic blooms of cyanobacteria has occurred in many regions of the world and could be a serious public health problem .',
  'The limited availability of commercially available standards for azaspiracids is a serious problem , because validated LC-MS methods are required for routine analysis of these toxins in shellfish tissues .',
  'Algal pollution in water sources has posed a serious problem .',
  'Contamination of water , foods and food supplements by various genera of cyanobacteria is a serious health problem worldwide for humans and animals , largely due to the toxic effects of microcystins ( MCs ) and nodularin ( NOD ) , a group of hepatotoxic cyclic peptides .',
  'Algal blooms are a serious problem in waters , which damage aquatic ecosystems and threaten drinking water safety .',
  'To explore the potential reporter gene assay for the detection of sodium channel-specific toxins in shellfish as an alternative for screening harmful algal bloom ( HAB ) toxins , considering the fact that the existing methods including HPLC and bioassay are inappropriate for identifying HAB toxins which poses a serious problem on human health and shellfish industry .',
  'Lipophilic marine toxins pose a serious threat for consumers and an enormous economic problem for shellfish producers .',
  'Cyanobacterial blooms are a frequent occurrence in northeastern Brazil and constitute a serious public health problem .',
  'Blooms of cyanobacteria , produced mainly as result of the pollution of water bodies with excessive amounts of phosphorus , represent a severe environmental problem ; not only do they affect the normal equilibrium of the aquatic ecosystem but may also affect animal and human health .',
  'However , algal blooms in urban rivers located downstream of eutrophicated lakes are also a serious problem for local administrators .',
  'Toxic cyanobacteria ( blue-green algae ) water blooms have become a serious problem in several industrialized areas of the world .',
  'The contamination of shellfish with marine biotoxins derived from microalgae represents a serious problem for shellfish industries and public health .',
  'Black blooms are a serious and complex problem for lake bays , with far-reaching implications for water quality and drinking safety .',
  'Algal bloom ( AB ) is a serious water environment problem in China , but it is still unclear how AB affects microorganisms with special functions ( such as nitrogen- , phosphorus- , sulfur- and iron-related bacteria ) at different AB stages .',
  'Toxic cyanobacteria represent a serious health and ecological problem in drinking and recreational waters worldwide .'],
 'algal': ['Harmful algal blooms ( HABs ) induced by eutrophication is becoming a serious global environmental problem affecting public health and aquatic ecological sustainability .',
  'The toxic cyanobacteria are a serious problem for water supply systems , recreation , and agriculture .',
  'The microcystins produced by cyanobacteria pose a serious problem to human health , if they contaminate drinking water or food .',
  'Harmful algal blooms , caused by massive and exceptional overgrowth of microalgae and cyanobacteria , are a serious environmental problem worldwide : In the present study , we looked for Bacillus strains with sufficiently strong anticyanobacterial activity to be used as biocontrol agents .',
  'In the Mediterranean Sea , periodic summer blooms have been reported and have become a serious concern due to their direct impact on human health and the environment .',
  'The eutrophication of aquatic ecosystems is a serious environmental problem that leads to increased frequency of cyanobacterial blooms and concentrations of cyanotoxins .',
  'Cyanobacterial blooms have become a serious problem in Lake Taihu during the last 20 years , and Microcystis aeruginosa and Synechococcus sp. are the two dominant species in cyanobacterial blooms of Lake Taihu .',
  'The prevalence of cyanobacterial blooms in fresh water bodies worldwide has become a serious environmental problem .',
  'Epiphytic filamentous algae ( EFA ) were noted as a serious problem to reduce the production and quality of K. alvarezii .',
  'This toxin is able to bioaccumulate in freshwater food webs , representing a serious human health problem .',
  'Harmful cyanobacterial bloom ( HCB ) by Microcystis aeruginosa is increasingly becoming a serious concern to the environment and human health alike .',
  'In recent years , the water pollution of cyanobacteria blooms has become a severe problem in this area .',
  'Green tide , which is a serious water pollution problem , is caused by the complex relationships of various factors , such as flow rate , several water quality indicators , and weather .',
  'Ciguatera fish poisoning ( CFP ) is a serious health problem in tropical regions and is caused by the bioaccumulation of lipophilic toxins produced by dinoflagellates in the genus Gambierdiscus .',
  'The presence of Ostreopsis cf . ovata on the Mediterranean coast represents a serious concern to human health due to production of toxins - putative palytoxin and ovatoxins ( ovatoxin-a , -b , -c , -d , -e , -f and -g ) .',
  'This phytoplankton is known to produce palytoxin-like compounds , listed among the most potent marine toxins known , and can pose a serious concern for humans in the Mediterranean area .',
  'Cyanobacteria and cyanotoxins constitute a serious environmental and human health problem .',
  'Once in the environment , A. baumannii is able to survive regardless of the availability of dissolved oxygen , which represents a serious public health concern .',
  'Excessive cyanobacterial growth in eutrophic water sources has been a serious environmental problem , and both sight preservation and drinking water production demand control of cyanobacterial growth in water .',
  'Harmful algal blooms ( HABs ) are a serious environmental problem globally .',
  'Because of the production of toxins such as Cylindrospermopsin ( CYN ) , contamination of water with cyanobacteria is a serious health problem around the world .',
  'Currently , the benthic dinoflagellate Ostreopsis cf . ovata represents a serious concern to human health in the whole Mediterranean basin due to the production of palytoxin congeners , a putative palytoxin and ovatoxins ( ovatoxin-a , -b , -c , -d/-e ) , listed among the most potent marine toxins .',
  'In particular , the presence of cyanobacteria toxins , especially microcystins ( MCs ) , has become a severe problem .',
  'Microcystin-producing Microcystis bloom is a severe water problem in the world .',
  'The HABs outbreak , often linked with anthropogenic eutrophication , has become a serious environmental health problem that threats our communities .',
  'The presence of the toxin cylindrospermopsin is increasingly frequent in samples from different ecosystems and it is a serious problem both at environmental level and for animal and human health .',
  'These blooms are often toxic and have become a serious health problem .',
  'The occurrence of harmful algal bloom in water source poses a serious water safety problem to local water supply systems .',
  'Cyanogenic potential ( CNp ) of cassava constitutes a serious problem for over 500 million people who rely on the crop as their main source of calories .',
  "Ulva prolifera green tide is a serious marine ecological problem in China 's coastal areas , with recurrent outbreaks occurring annually during late spring and summer since 2007 .",
  'Blooms of benthic dinoflagellates of the genus Ostreopsis ( mainly O. cf . ovata and occasionally O. cf . siamensis ) represent a serious concern for humans in the Mediterranean area , due to production of palytoxin-like compounds listed among the most potent marine toxins known .',
  'Contamination of water by cyanobacteria ( blue-green algae ) is a serious health problem around the world , largely due to the toxic effects of microcystins , a group of potent hepatotoxins .',
  'Harmful algal blooms ( HABs ) has been a serious problem in recent years , because of large quantities of cyanobacterial in eutrophic water .',
  'In fjord systems , Harmful Algal Blooms ( HABs ) not only constitute a serious problem when affecting the wildlife and ecosystems , but also human health and economic activities related to the marine environment .',
  'The development of mucilaginous cyanobacterial Microcystis blooms is a serious environmental and ecological problem , and information on the bloom-formation mechanism has been lacking until now .',
  'The increasing cyanobacterial blooms have recently been considered a severe environmental problem .',
  'The release of toxic hydrogen cyanide ( HCN ) from endogenous CNglcs , which is known as cyanogenesis , leads to a serious problem for animal consumption while as defensive secondary metabolites , CNglcs play multiple roles in plant development and responses to adverse environment .',
  'Taste and odor pollution caused by secondary metabolites from cyanobacterial blooms has become a serious and widespread environmental problem .',
  'Each year there are more frequent blooms of green algae and cyanobacteria , representing a serious environmental problem of eutrophication .',
  'In recent years cyanobacteria blooms have become a severe problem in Taihu Lake , a large shallow eutrophic lake in China .',
  'Contamination of water on toxic blooms of cyanobacteria has occurred in many regions of the world and could be a serious public health problem .',
  'The limited availability of commercially available standards for azaspiracids is a serious problem , because validated LC-MS methods are required for routine analysis of these toxins in shellfish tissues .',
  'Algal pollution in water sources has posed a serious problem .',
  'Contamination of water , foods and food supplements by various genera of cyanobacteria is a serious health problem worldwide for humans and animals , largely due to the toxic effects of microcystins ( MCs ) and nodularin ( NOD ) , a group of hepatotoxic cyclic peptides .',
  'Algal blooms are a serious problem in waters , which damage aquatic ecosystems and threaten drinking water safety .',
  'To explore the potential reporter gene assay for the detection of sodium channel-specific toxins in shellfish as an alternative for screening harmful algal bloom ( HAB ) toxins , considering the fact that the existing methods including HPLC and bioassay are inappropriate for identifying HAB toxins which poses a serious problem on human health and shellfish industry .',
  'Lipophilic marine toxins pose a serious threat for consumers and an enormous economic problem for shellfish producers .',
  'Cyanobacterial blooms are a frequent occurrence in northeastern Brazil and constitute a serious public health problem .',
  'Blooms of cyanobacteria , produced mainly as result of the pollution of water bodies with excessive amounts of phosphorus , represent a severe environmental problem ; not only do they affect the normal equilibrium of the aquatic ecosystem but may also affect animal and human health .',
  'However , algal blooms in urban rivers located downstream of eutrophicated lakes are also a serious problem for local administrators .',
  'Toxic cyanobacteria ( blue-green algae ) water blooms have become a serious problem in several industrialized areas of the world .',
  'The contamination of shellfish with marine biotoxins derived from microalgae represents a serious problem for shellfish industries and public health .',
  'Black blooms are a serious and complex problem for lake bays , with far-reaching implications for water quality and drinking safety .',
  'Algal bloom ( AB ) is a serious water environment problem in China , but it is still unclear how AB affects microorganisms with special functions ( such as nitrogen- , phosphorus- , sulfur- and iron-related bacteria ) at different AB stages .',
  'Toxic cyanobacteria represent a serious health and ecological problem in drinking and recreational waters worldwide .'],
 'toxins': ['Harmful algal blooms ( HABs ) induced by eutrophication is becoming a serious global environmental problem affecting public health and aquatic ecological sustainability .',
  'The toxic cyanobacteria are a serious problem for water supply systems , recreation , and agriculture .',
  'The microcystins produced by cyanobacteria pose a serious problem to human health , if they contaminate drinking water or food .',
  'Harmful algal blooms , caused by massive and exceptional overgrowth of microalgae and cyanobacteria , are a serious environmental problem worldwide : In the present study , we looked for Bacillus strains with sufficiently strong anticyanobacterial activity to be used as biocontrol agents .',
  'In the Mediterranean Sea , periodic summer blooms have been reported and have become a serious concern due to their direct impact on human health and the environment .',
  'The eutrophication of aquatic ecosystems is a serious environmental problem that leads to increased frequency of cyanobacterial blooms and concentrations of cyanotoxins .',
  'Cyanobacterial blooms have become a serious problem in Lake Taihu during the last 20 years , and Microcystis aeruginosa and Synechococcus sp. are the two dominant species in cyanobacterial blooms of Lake Taihu .',
  'The prevalence of cyanobacterial blooms in fresh water bodies worldwide has become a serious environmental problem .',
  'Epiphytic filamentous algae ( EFA ) were noted as a serious problem to reduce the production and quality of K. alvarezii .',
  'This toxin is able to bioaccumulate in freshwater food webs , representing a serious human health problem .',
  'Harmful cyanobacterial bloom ( HCB ) by Microcystis aeruginosa is increasingly becoming a serious concern to the environment and human health alike .',
  'In recent years , the water pollution of cyanobacteria blooms has become a severe problem in this area .',
  'Green tide , which is a serious water pollution problem , is caused by the complex relationships of various factors , such as flow rate , several water quality indicators , and weather .',
  'Ciguatera fish poisoning ( CFP ) is a serious health problem in tropical regions and is caused by the bioaccumulation of lipophilic toxins produced by dinoflagellates in the genus Gambierdiscus .',
  'The presence of Ostreopsis cf . ovata on the Mediterranean coast represents a serious concern to human health due to production of toxins - putative palytoxin and ovatoxins ( ovatoxin-a , -b , -c , -d , -e , -f and -g ) .',
  'This phytoplankton is known to produce palytoxin-like compounds , listed among the most potent marine toxins known , and can pose a serious concern for humans in the Mediterranean area .',
  'Cyanobacteria and cyanotoxins constitute a serious environmental and human health problem .',
  'Once in the environment , A. baumannii is able to survive regardless of the availability of dissolved oxygen , which represents a serious public health concern .',
  'Excessive cyanobacterial growth in eutrophic water sources has been a serious environmental problem , and both sight preservation and drinking water production demand control of cyanobacterial growth in water .',
  'Harmful algal blooms ( HABs ) are a serious environmental problem globally .',
  'Because of the production of toxins such as Cylindrospermopsin ( CYN ) , contamination of water with cyanobacteria is a serious health problem around the world .',
  'Currently , the benthic dinoflagellate Ostreopsis cf . ovata represents a serious concern to human health in the whole Mediterranean basin due to the production of palytoxin congeners , a putative palytoxin and ovatoxins ( ovatoxin-a , -b , -c , -d/-e ) , listed among the most potent marine toxins .',
  'In particular , the presence of cyanobacteria toxins , especially microcystins ( MCs ) , has become a severe problem .',
  'Microcystin-producing Microcystis bloom is a severe water problem in the world .',
  'The HABs outbreak , often linked with anthropogenic eutrophication , has become a serious environmental health problem that threats our communities .',
  'The presence of the toxin cylindrospermopsin is increasingly frequent in samples from different ecosystems and it is a serious problem both at environmental level and for animal and human health .',
  'These blooms are often toxic and have become a serious health problem .',
  'The occurrence of harmful algal bloom in water source poses a serious water safety problem to local water supply systems .',
  'Cyanogenic potential ( CNp ) of cassava constitutes a serious problem for over 500 million people who rely on the crop as their main source of calories .',
  "Ulva prolifera green tide is a serious marine ecological problem in China 's coastal areas , with recurrent outbreaks occurring annually during late spring and summer since 2007 .",
  'Blooms of benthic dinoflagellates of the genus Ostreopsis ( mainly O. cf . ovata and occasionally O. cf . siamensis ) represent a serious concern for humans in the Mediterranean area , due to production of palytoxin-like compounds listed among the most potent marine toxins known .',
  'Contamination of water by cyanobacteria ( blue-green algae ) is a serious health problem around the world , largely due to the toxic effects of microcystins , a group of potent hepatotoxins .',
  'Harmful algal blooms ( HABs ) has been a serious problem in recent years , because of large quantities of cyanobacterial in eutrophic water .',
  'In fjord systems , Harmful Algal Blooms ( HABs ) not only constitute a serious problem when affecting the wildlife and ecosystems , but also human health and economic activities related to the marine environment .',
  'The development of mucilaginous cyanobacterial Microcystis blooms is a serious environmental and ecological problem , and information on the bloom-formation mechanism has been lacking until now .',
  'The increasing cyanobacterial blooms have recently been considered a severe environmental problem .',
  'The release of toxic hydrogen cyanide ( HCN ) from endogenous CNglcs , which is known as cyanogenesis , leads to a serious problem for animal consumption while as defensive secondary metabolites , CNglcs play multiple roles in plant development and responses to adverse environment .',
  'Taste and odor pollution caused by secondary metabolites from cyanobacterial blooms has become a serious and widespread environmental problem .',
  'Each year there are more frequent blooms of green algae and cyanobacteria , representing a serious environmental problem of eutrophication .',
  'In recent years cyanobacteria blooms have become a severe problem in Taihu Lake , a large shallow eutrophic lake in China .',
  'Contamination of water on toxic blooms of cyanobacteria has occurred in many regions of the world and could be a serious public health problem .',
  'The limited availability of commercially available standards for azaspiracids is a serious problem , because validated LC-MS methods are required for routine analysis of these toxins in shellfish tissues .',
  'Algal pollution in water sources has posed a serious problem .',
  'Contamination of water , foods and food supplements by various genera of cyanobacteria is a serious health problem worldwide for humans and animals , largely due to the toxic effects of microcystins ( MCs ) and nodularin ( NOD ) , a group of hepatotoxic cyclic peptides .',
  'Algal blooms are a serious problem in waters , which damage aquatic ecosystems and threaten drinking water safety .',
  'To explore the potential reporter gene assay for the detection of sodium channel-specific toxins in shellfish as an alternative for screening harmful algal bloom ( HAB ) toxins , considering the fact that the existing methods including HPLC and bioassay are inappropriate for identifying HAB toxins which poses a serious problem on human health and shellfish industry .',
  'Lipophilic marine toxins pose a serious threat for consumers and an enormous economic problem for shellfish producers .',
  'Cyanobacterial blooms are a frequent occurrence in northeastern Brazil and constitute a serious public health problem .',
  'Blooms of cyanobacteria , produced mainly as result of the pollution of water bodies with excessive amounts of phosphorus , represent a severe environmental problem ; not only do they affect the normal equilibrium of the aquatic ecosystem but may also affect animal and human health .',
  'However , algal blooms in urban rivers located downstream of eutrophicated lakes are also a serious problem for local administrators .',
  'Toxic cyanobacteria ( blue-green algae ) water blooms have become a serious problem in several industrialized areas of the world .',
  'The contamination of shellfish with marine biotoxins derived from microalgae represents a serious problem for shellfish industries and public health .',
  'Black blooms are a serious and complex problem for lake bays , with far-reaching implications for water quality and drinking safety .',
  'Algal bloom ( AB ) is a serious water environment problem in China , but it is still unclear how AB affects microorganisms with special functions ( such as nitrogen- , phosphorus- , sulfur- and iron-related bacteria ) at different AB stages .',
  'Toxic cyanobacteria represent a serious health and ecological problem in drinking and recreational waters worldwide .'],
 'fever': ['Chikungunya fever is an emerging arbovirus infection , representing a serious public health problem .',
  'Scrub typhus ( ST ) has emerged as a serious public health problem in India .',
  "Hemorrhagic fever with renal syndrome ( HFRS ) is a serious public health problem in the People 's Republic of China .",
  'Several arenaviruses , such as Lassa virus in West Africa , and Junin , Guanarito , Sabia , Machupo , and Chapare viruses in South America , cause sever viral hemorrhagic fevers ( VHF ) in humans and represent a serious public health problem .',
  'Crimean Congo hemorrhagic fever is a fatal systemic viral infection which is an important health problem in Turkey .',
  'Hemorrhagic fever with renal syndrome is a serious health concern in neighboring countries of Taiwan , such as mainland China and Korea .',
  'The results of the current study enhance the belief that murine typhus is a serious public health problem in Cyprus .',
  'Junin virus ( JUNV ) has been identified as the aetiological agent of Argentine haemorrhagic fever ( AHF ) , which is a serious public health problem with approximately 5 million people at risk .',
  'Arthritogenic alphaviruses such as the chikungunya virus ( CHIKV ) , the Ross River virus ( RRV ) and the Mayaro virus ( MAYV ) have become a serious public health concern in recent years .',
  'Typhoid fever remains a serious problem in developing countries .',
  'Paratyphoid fever caused by Salmonella Paratyphi A is a serious public health problem in many countries .',
  'In the absence of available vaccines or therapeutic agents , the hemorrhagic fever arenaviruses remain a serious public health and biodefense concern .',
  'Hemorrhagic fever with renal syndrome ( HFRS ) is a serious public health problem in Shandong Province , China .',
  'Typhoid perforation ileitis is a serious complication of typhoid fever , a common and unfortunate health problem in a resource-poor country like Nigeria .',
  'Typhoid fever remains a serious problem in many developing countries .',
  'Hemorrhagic fever with renal syndrome is a serious health problem in Eurasian countries , including Korea and China .',
  'Typhoid fever remains a serious public health problem .',
  'Typhoid fever , caused by the pathogen Salmonella enterica serovar Typhi ( S. Typhi ) , is a serious global health concern .',
  'In conclusion drug resistant typhoid fever will become a serious problem in Indonesia in the future , requiring the use of expensive drugs for the treatment of typhoid .',
  'In recent years , hemorrhagic fever with renal syndrome ( HFRS ) incidence has been becoming a severe public health problem again due to its significant increase in Shaanxi Province , China .',
  'Arbovirus infections are a serious concern in tropical countries due to their high levels of transmission and morbidity .',
  'Scrub typhus is a serious public health problem in the Asia-Pacific area .',
  'Typhoid fever remains a serious public health problem in developing countries , especially among young children .',
  'Data collected in two years of operation demonstrate that Lassa fever is a serious public health problem in Edo State and reveal new insights into the disease in hospitalized patients .',
  'Rickettsial diseases ( typhus and spotted fever group rickettsioses , scrub typhus and Q fever ) may pose a serious public health problem , namely when they are non-diagnosed or misdiagnosed .',
  'Pandemic V. parahaemolyticus isolates have become a serious public health concern .',
  'Hemorrhagic fever with renal syndrome ( HFRS ) , an infectious disease caused by hantaviruses , is endemic in China and remains a serious public health problem .',
  'Detection of a significant number of positive Widal tests in conditions where it is expected to be nonreactive appears to be a serious problem in making a correct diagnosis of typhoid fever , thus challenging the diagnostic utility of the Widal test .',
  'Crimean-Congo hemorrhagic fever ( CCHF ) is a fatal systemic viral infection which is an important health problem in Turkey .',
  'Scrub typhus , a serious public health problem in the Asia-Pacific area , is endemic in the " tsutsugamushi triangle " area .',
  'Fever of unknown origin ( FUO ) is a serious problem in the United States .',
  'Typhoid fever remains a serious public health problem with a high impact on toddlers and young children .',
  'Moderately and severely immunocompromised travellers are at increased risk of developing a serious health problem during or after a trip in a tropical country .',
  'In the past decade the disease has been recognized as a serious problem in 19 provinces of China and in Japan , where the virus is the Hantaan virus .',
  'Magnetic resonance ( MR ) imaging of the kidneys was performed in 14 patients with a severe form of hemorrhagic fever with renal syndrome ( HFRS ) , a major public health problem in Far Eastern Asia .',
  'Typhoid and paratyphoid fevers ( TPF ) , systemic emerging infectious diseases , is a serious health problem for society .',
  'Arboviruses , arthropod-borneviruses , are frequency associated to human outbreak and represent a serious health problem .',
  'In Poland each year between the first and the second world war typhoid fever was a serious sanitary problem .',
  'Typhoid fever is a global infectious disease which remains a severe health problem in Asia and Africa .',
  'Hemorrhagic fever with renal syndrome is a serious health problem in Eurasian countries .',
  'These viruses are causative agents of hemorrhagic fever with renal syndrome ( HFRS ) , which is recognized as a severe health care problem in several countries .',
  'Being a globally emerging mite-borne zoonotic disease , scrub typhus is a serious public health concern in Nepal .',
  'Crimean-Congo Hemorrhagic Fever ( CCHF ) is a severe tick-borne viral hemorrhagic disease caused by Crimean-Congo Hemorrhagic Fever Virus ( CCHFV ) that poses serious public health challenges in many parts of Africa , Europe and Asia .',
  'Typhoid fever remains a severe public health problem in developing countries .',
  'Typhoid fever , caused by Salmonella enterica serovar Typhi ( S. Typhi ) , remains a serious global health concern .',
  'Hemorrhagic fever with renal syndrome ( HFRS ) caused by hantaviruses is a serious public health problem in China .',
  'The fever of unknown origin from time to time constitutes a serious clinical problem and nearly all diagnostic methods are involved to discover urgently its cause .',
  'Undiagnosed fever is a vexing problem .',
  'The recent outbreak of Chikungunya virus in Italy represents a serious public health concern , which is attracting media coverage and generating public interest in terms of Internet searches and social media interactions .',
  'Hantaan virus ( HTNV ) infection in humans is a serious public health concern in Asia .',
  'Fever of Unknown Origin ( FUO ) is a vexing clinical problem .',
  'Ebola virus ( EBOV ) disease ( EVD ) leads to lethal hemorrhagic fever with a case fatality rate as high as 90 % , thus posing a serious global public health concern .',
  'Arboviruses are frequently associated with outbreaks in humans and represent a serious public health problem .',
  'Typhoid fever is a serious infection , and special concern arises when S. typhi complicates pregnancy .',
  'Hemorrhagic fever with renal syndrome ( HFRS ) is a serious public health problem in China , and is primarily caused by either the Hantaan virus ( HTNV ) or Seoul virus ( SEOV ) strains .',
  'Clonal recycling of hybrid El Tor with increasing virulence in a changing climate and in a region with a growing urban population represents a serious public health concern for Bangladesh .',
  'Typhoid fever is a serious public health problem in Egypt .',
  'Hemorrhagic fever with renal syndrome ( HFRS ) caused by hantaviruses is a serious public health problem in China , accounting for 90 % of HFRS cases reported globally .'],
 'cutaneous': ['Zoonotic cutaneous leishmaniasis ( ZCL ) is a serious and increasing public health problem in many rural areas of Iran .',
  'The cutaneous leishmaniasis ( CL ) is a parasitic disease which represents a serious problem for the public health not only in Tunisia but also all over the world .',
  'Zoonotic Cutaneous Leishmaniasis ( ZCL ) is still a serious health problem in Iran .',
  'Visceral leishmaniasis ( VL ) is a serious health problem in Iran .',
  'Cutaneous leishmaniasis is currently a serious public health problem in northern Africa , especially in Morocco .',
  'Human leishmaniasis , both visceral and cutaneous , has been reported in Morocco for centuries and constitutes a serious public health problem .',
  'Pakistan is one of the countries in which cutaneous leishmaniasis is becoming an epidemic disease and because of its morbidity and disfiguring scars , it is considered a serious public health problem .',
  'Zoonotic cutaneous leishmaniasis ( ZCL ) is a serious and increasing public health problem in many parts of Saudi Arabia .',
  'Cutaneous leishmaniasis due to Leishmania major is a serious and increasing problem affecting many rural areas of 17 out of 31 provinces in Iran .',
  'Zoonotic cutaneous leishmaniasis ( ZCL ) constitutes a serious public health problem in many parts of the world including Iran .',
  'Leishmaniasis is a serious public health problem in Yemen .',
  'Leishmaniasis remains a serious public health problem in several parts of the developing world .',
  'Cutaneous Leishmaniasis is a serious public health problem , typically affecting poor populations with limited access to health care .',
  'Cutaneous leishmaniasis ( CL ) remains a serious public health concern in Kerman Province , eastern Iran .'],
 'morocco': ['Zoonotic cutaneous leishmaniasis ( ZCL ) is a serious and increasing public health problem in many rural areas of Iran .',
  'The cutaneous leishmaniasis ( CL ) is a parasitic disease which represents a serious problem for the public health not only in Tunisia but also all over the world .',
  'Zoonotic Cutaneous Leishmaniasis ( ZCL ) is still a serious health problem in Iran .',
  'Visceral leishmaniasis ( VL ) is a serious health problem in Iran .',
  'Cutaneous leishmaniasis is currently a serious public health problem in northern Africa , especially in Morocco .',
  'Human leishmaniasis , both visceral and cutaneous , has been reported in Morocco for centuries and constitutes a serious public health problem .',
  'Pakistan is one of the countries in which cutaneous leishmaniasis is becoming an epidemic disease and because of its morbidity and disfiguring scars , it is considered a serious public health problem .',
  'Zoonotic cutaneous leishmaniasis ( ZCL ) is a serious and increasing public health problem in many parts of Saudi Arabia .',
  'Cutaneous leishmaniasis due to Leishmania major is a serious and increasing problem affecting many rural areas of 17 out of 31 provinces in Iran .',
  'Zoonotic cutaneous leishmaniasis ( ZCL ) constitutes a serious public health problem in many parts of the world including Iran .',
  'Leishmaniasis is a serious public health problem in Yemen .',
  'Leishmaniasis remains a serious public health problem in several parts of the developing world .',
  'Cutaneous Leishmaniasis is a serious public health problem , typically affecting poor populations with limited access to health care .',
  'Cutaneous leishmaniasis ( CL ) remains a serious public health concern in Kerman Province , eastern Iran .'],
 'pe': ['Pulmonary embolism is also a serious problem that occurs in more than 500,000patients per year , of whom approximately 200,000will die .',
  'Pulmonary embolism is a serious and difficult problem .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem and computed tomography pulmonary angiography ( CTPA ) is the gold standard for diagnosis .',
  'Computed tomography pulmonary angiography ( CTPA ) is the standard imaging modality for detection or rule out of pulmonary embolism ( PE ) ; however , radiation exposure is a serious concern .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem , and computed tomographic imaging is the standard for diagnosis .',
  'Septic pulmonary embolism is a serious but uncommon syndrome posing diagnostic challenges because of its broad range of clinical presentation and etiologies .',
  'The Pulmonary Embolism Response Team ( PERT ) is a multidisciplinary team that quickly evaluates , coordinates diagnosis , and optimizes management for patients with pulmonary embolism ( PE ) , a serious public health problem .',
  'Diagnosis and management of the patient with pulmonary embolism remains a vexing clinical problem .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem and computed tomography pulmonary angiography ( CTPA ) is the gold standard for diagnosis .',
  'Although massive pulmonary tumor embolism occurs relatively rarely , it can be a catastrophic problem .'],
 'ctpa': ['Pulmonary embolism is also a serious problem that occurs in more than 500,000patients per year , of whom approximately 200,000will die .',
  'Pulmonary embolism is a serious and difficult problem .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem and computed tomography pulmonary angiography ( CTPA ) is the gold standard for diagnosis .',
  'Computed tomography pulmonary angiography ( CTPA ) is the standard imaging modality for detection or rule out of pulmonary embolism ( PE ) ; however , radiation exposure is a serious concern .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem , and computed tomographic imaging is the standard for diagnosis .',
  'Septic pulmonary embolism is a serious but uncommon syndrome posing diagnostic challenges because of its broad range of clinical presentation and etiologies .',
  'The Pulmonary Embolism Response Team ( PERT ) is a multidisciplinary team that quickly evaluates , coordinates diagnosis , and optimizes management for patients with pulmonary embolism ( PE ) , a serious public health problem .',
  'Diagnosis and management of the patient with pulmonary embolism remains a vexing clinical problem .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem and computed tomography pulmonary angiography ( CTPA ) is the gold standard for diagnosis .',
  'Although massive pulmonary tumor embolism occurs relatively rarely , it can be a catastrophic problem .'],
 'angiography': ['Pulmonary embolism is also a serious problem that occurs in more than 500,000patients per year , of whom approximately 200,000will die .',
  'Pulmonary embolism is a serious and difficult problem .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem and computed tomography pulmonary angiography ( CTPA ) is the gold standard for diagnosis .',
  'Subarachnoid hemorrhage ( SAH ) is a devastating form of stroke , which poses a series of intractable challenges to clinical practice .',
  'Aneurysmal subarachnoid hemorrhage ( aSAH ) is a devastating problem .',
  'Computed tomography pulmonary angiography ( CTPA ) is the standard imaging modality for detection or rule out of pulmonary embolism ( PE ) ; however , radiation exposure is a serious concern .',
  'Cerebral aneurysm re-rupture following subarachnoid hemorrhage(SAH)is a serious problem that is related with poor outcome .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem , and computed tomographic imaging is the standard for diagnosis .',
  'Aneurysmal subarachnoid hemorrhage is a serious medical and social problem .',
  'Septic pulmonary embolism is a serious but uncommon syndrome posing diagnostic challenges because of its broad range of clinical presentation and etiologies .',
  'Subarachnoid hemorrhage ( SAH ) is a serious medical problem with few effective pharmacotherapies available , and neuroinflammation has been identified as an important pathological process in early brain injury ( EBI ) after SAH .',
  'Cerebral vasospasm secondary to subarachnoid hemorrhage ( SAH ) has been a serious clinical problem .',
  'The Pulmonary Embolism Response Team ( PERT ) is a multidisciplinary team that quickly evaluates , coordinates diagnosis , and optimizes management for patients with pulmonary embolism ( PE ) , a serious public health problem .',
  'Diagnosis and management of the patient with pulmonary embolism remains a vexing clinical problem .',
  'The development of delayed cerebral ischaemia and hence neurological deficit remains a serious problem following subarachnoid haemorrhage .',
  'While the risk of aneurysmal rebleeding induced by catheter cerebral angiography is a serious concern and can delay angiography for a few hours after a subarachnoid hemorrhage ( SAH ) , current angiographic technology and techniques have been much improved .',
  'Delayed neurologic deficits secondary to vasospasm remain a vexing problem .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem and computed tomography pulmonary angiography ( CTPA ) is the gold standard for diagnosis .',
  'Cerebral vasospasm remains a serious problem affecting morbidity and mortality in patients with subarachnoid hemorrhage ( SAH ) during neurosurgery .',
  'Although massive pulmonary tumor embolism occurs relatively rarely , it can be a catastrophic problem .',
  'Despite decades of study , subarachnoid hemorrhage ( SAH ) continues to be a serious and significant health problem in the United States and worldwide .',
  'Poor outcome in patients with cerebral vasospasm following subarachnoid hemorrhage remains a serious clinical problem .'],
 'tomography': ['Pulmonary embolism is also a serious problem that occurs in more than 500,000patients per year , of whom approximately 200,000will die .',
  'Pulmonary embolism is a serious and difficult problem .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem and computed tomography pulmonary angiography ( CTPA ) is the gold standard for diagnosis .',
  'Computed tomography pulmonary angiography ( CTPA ) is the standard imaging modality for detection or rule out of pulmonary embolism ( PE ) ; however , radiation exposure is a serious concern .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem , and computed tomographic imaging is the standard for diagnosis .',
  'Septic pulmonary embolism is a serious but uncommon syndrome posing diagnostic challenges because of its broad range of clinical presentation and etiologies .',
  'The Pulmonary Embolism Response Team ( PERT ) is a multidisciplinary team that quickly evaluates , coordinates diagnosis , and optimizes management for patients with pulmonary embolism ( PE ) , a serious public health problem .',
  'Diagnosis and management of the patient with pulmonary embolism remains a vexing clinical problem .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem and computed tomography pulmonary angiography ( CTPA ) is the gold standard for diagnosis .',
  'Although massive pulmonary tumor embolism occurs relatively rarely , it can be a catastrophic problem .'],
 'diagnosis': ['Pulmonary embolism is also a serious problem that occurs in more than 500,000patients per year , of whom approximately 200,000will die .',
  'Pulmonary embolism is a serious and difficult problem .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem and computed tomography pulmonary angiography ( CTPA ) is the gold standard for diagnosis .',
  'Computed tomography pulmonary angiography ( CTPA ) is the standard imaging modality for detection or rule out of pulmonary embolism ( PE ) ; however , radiation exposure is a serious concern .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem , and computed tomographic imaging is the standard for diagnosis .',
  'Septic pulmonary embolism is a serious but uncommon syndrome posing diagnostic challenges because of its broad range of clinical presentation and etiologies .',
  'The Pulmonary Embolism Response Team ( PERT ) is a multidisciplinary team that quickly evaluates , coordinates diagnosis , and optimizes management for patients with pulmonary embolism ( PE ) , a serious public health problem .',
  'Diagnosis and management of the patient with pulmonary embolism remains a vexing clinical problem .',
  'Pulmonary embolism ( PE ) is a life-threatening clinical problem and computed tomography pulmonary angiography ( CTPA ) is the gold standard for diagnosis .',
  'Although massive pulmonary tumor embolism occurs relatively rarely , it can be a catastrophic problem .'],
 'candidiasis': ['Although the candidemia still remains a serious health problem , the study of candidemia in cancer patients is limited .',
  'Systemic Candida infections pose a serious public health problem with high morbidity and mortality .',
  'Candidaemia still continues to be a serious medical concern and the epidemiology of candidaemia varies according to geographical areas .',
  'Disseminated candidiasis is a serious problem in public health that results from the invasion of Candida species , in particular Candida albicans .',
  'Oropharyngeal candidiasis is emerging as a serious health problem in the elderly as well as other chronically immunosuppressed patient populations .',
  'Oral candidiasis represents a serious problem for children with cancer .',
  'Since the 1990s , the substantial increase in the rate of Candida glabrata infections has become a serious problem .',
  'Oral candidiasis is a serious problem for immunocompromised patients , especially patients with hematological malignancies .',
  'Candidiasis represents a critical problem to human health and a serious concern worldwide .',
  'Invasive candidiasis , mainly caused by Candida albicans , is a serious healthcare problem with high mortality rates , particularly in immunocompromised patients .',
  'Infections by Candida albicans and related fungal pathogens pose a serious health problem for immunocompromised patients .',
  'A serious problem for humans is the propensity of Candida albicans to adhere to various surfaces and its ability to form biofilms .',
  'The emergence of Candida glabrata infections among patients with compromised immunity has become a serious concern , especially at centers caring for individuals with cancer .',
  'Esophageal candidiasis can be a serious problem in predisposed individuals , and it can be the first opportunistic infection suggesting overt AIDS in HIV-seropositive patients .',
  'Deep-seated Candida infections and invasive aspergilloma are becoming a serious problem for individuals who need intensive care .',
  'Vulvovaginal candidiasis is a serious health problem affecting numerous women around the world .',
  'Invasive candidiasis is a life-threatening complication problem in post-operative and immunocompromized patients , e.g. those treated by intensive care .',
  'Candida infection has been a serious health problem due to the inappropriate use of antibiotics .',
  'Vulvovaginal candidiasis ( VVC ) in HIV-infected ( HIV+ ) women is a serious public health problem .',
  'Acute disseminated candidiasis is a serious and difficult problem often seen in immunocompromised states .',
  'The increasing number of Candida infections , especially those caused by non-C. \xa0 albicans species and resistant strains , is a serious medical problem .',
  'It has been a serious problem that candida sepsis is increasing followed thermal injury , which related to the increasing use of antibiotics in part .',
  'We conclude that in an institution mainly oriented toward management of cancer and surgical patients , systemic and visceral candidiasis are common and represent a serious problem .',
  'Candida species are responsible for various clinical infections ranging from mucocutaneous infection to life threatening invasive diseases along with increased resistance to antifungal drugs has made a serious concern .'],
 'candida': ['Although the candidemia still remains a serious health problem , the study of candidemia in cancer patients is limited .',
  'Systemic Candida infections pose a serious public health problem with high morbidity and mortality .',
  'Candidaemia still continues to be a serious medical concern and the epidemiology of candidaemia varies according to geographical areas .',
  'Disseminated candidiasis is a serious problem in public health that results from the invasion of Candida species , in particular Candida albicans .',
  'Oropharyngeal candidiasis is emerging as a serious health problem in the elderly as well as other chronically immunosuppressed patient populations .',
  'Oral candidiasis represents a serious problem for children with cancer .',
  'Since the 1990s , the substantial increase in the rate of Candida glabrata infections has become a serious problem .',
  'Oral candidiasis is a serious problem for immunocompromised patients , especially patients with hematological malignancies .',
  'Candidiasis represents a critical problem to human health and a serious concern worldwide .',
  'Invasive candidiasis , mainly caused by Candida albicans , is a serious healthcare problem with high mortality rates , particularly in immunocompromised patients .',
  'Infections by Candida albicans and related fungal pathogens pose a serious health problem for immunocompromised patients .',
  'A serious problem for humans is the propensity of Candida albicans to adhere to various surfaces and its ability to form biofilms .',
  'The emergence of Candida glabrata infections among patients with compromised immunity has become a serious concern , especially at centers caring for individuals with cancer .',
  'Esophageal candidiasis can be a serious problem in predisposed individuals , and it can be the first opportunistic infection suggesting overt AIDS in HIV-seropositive patients .',
  'Deep-seated Candida infections and invasive aspergilloma are becoming a serious problem for individuals who need intensive care .',
  'Vulvovaginal candidiasis is a serious health problem affecting numerous women around the world .',
  'Invasive candidiasis is a life-threatening complication problem in post-operative and immunocompromized patients , e.g. those treated by intensive care .',
  'Candida infection has been a serious health problem due to the inappropriate use of antibiotics .',
  'Vulvovaginal candidiasis ( VVC ) in HIV-infected ( HIV+ ) women is a serious public health problem .',
  'Acute disseminated candidiasis is a serious and difficult problem often seen in immunocompromised states .',
  'The increasing number of Candida infections , especially those caused by non-C. \xa0 albicans species and resistant strains , is a serious medical problem .',
  'It has been a serious problem that candida sepsis is increasing followed thermal injury , which related to the increasing use of antibiotics in part .',
  'We conclude that in an institution mainly oriented toward management of cancer and surgical patients , systemic and visceral candidiasis are common and represent a serious problem .',
  'Candida species are responsible for various clinical infections ranging from mucocutaneous infection to life threatening invasive diseases along with increased resistance to antifungal drugs has made a serious concern .'],
 'shortage': ["The loss or deficiency of a tissue or organ is a serious health problem and severely affects the patients ' quality of life .",
  'The organ shortage for transplantation , the principal factor that increases waiting lists , has become a serious public health problem .',
  'The persisting organ shortage remains a serious problem .',
  'The disproportion between the large organ demand and the low number of transplantations performed represents a serious public health problem worldwide .',
  'There is a severe shortage of human organs available for transplantation and xenotransplantation - use of animal organs has long been suggested to overcome this problem .',
  'In spite of the recent advances in transplantation techniques , donor organ shortage remains a serious problem .',
  'The shortage of organ donors has become a serious problem in modern medicine .',
  'The lack of donor grafts is a severe problem in transplantation medicine .',
  'The shortage of human organs for transplantation is a devastating medical problem .',
  'In hair transplantation , the availability of a limited number of grafts for a conventional transplantation can pose a serious problem .',
  'The shortage of organs and tissues for transplantation is considered a serious global problem .',
  'However , this approach has a serious problem in that donor organs maintain healthy conditions only during short-term storage .',
  'Establishing fair allocation priorities is a serious problem in organ transplantation .',
  'Shortage of donor organs is a serious problem for transplantation medicine .',
  'A shortage of organ donors for transplantation has become a serious problem throughout the world .',
  'Waitlist mortality due to donor shortage for lung transplantation is a serious problem worldwide .',
  'The small number of organs available for transplant poses a serious problem .',
  'A severe problem is the the scarcity of suitable donors for the very low weight children who are candidates for LSBT .',
  'Turkey is one of the countries facing a serious organ shortage problem , with thousands of patients with end-stage organ failure .',
  'A severe shortage of suitable allografts is a long-standing and worldwide problem for patients who are waiting for organ transplantation .',
  'However , the shortage of donor skin tissues is a serious problem .',
  'However , when a severe health problem occurs in a donor while the recipient has already received a conditioning regimen , hematologists have to find the best solutions for the recipient , while the team in charge of the donor has to find the best medical solutions for the donor .',
  'A shortage of donors poses a serious problem for organ transplantation around the world .',
  'However , the imbalance between the supply and the demand for human organs is a serious problem in modern transplantology .',
  'The recent increase of the number of unidentified cadavers has become a serious problem throughout the world .',
  'The shortage of organ donors is a serious problem in Japan .',
  'The shortage of donors has become a serious problem .',
  'Organ shortages are a serious problem , even in the United States .',
  'To increase the number of available pulmonary grafts , we have tried various strategies , such as active use of marginal donors , careful donor management , and development of new preservation solutions , but the shortage of brain-dead donors remains a serious problem .'],
 'donor': ["The loss or deficiency of a tissue or organ is a serious health problem and severely affects the patients ' quality of life .",
  'The organ shortage for transplantation , the principal factor that increases waiting lists , has become a serious public health problem .',
  'The persisting organ shortage remains a serious problem .',
  'The disproportion between the large organ demand and the low number of transplantations performed represents a serious public health problem worldwide .',
  'There is a severe shortage of human organs available for transplantation and xenotransplantation - use of animal organs has long been suggested to overcome this problem .',
  'In spite of the recent advances in transplantation techniques , donor organ shortage remains a serious problem .',
  'The shortage of organ donors has become a serious problem in modern medicine .',
  'The lack of donor grafts is a severe problem in transplantation medicine .',
  'The shortage of human organs for transplantation is a devastating medical problem .',
  'In hair transplantation , the availability of a limited number of grafts for a conventional transplantation can pose a serious problem .',
  'The shortage of organs and tissues for transplantation is considered a serious global problem .',
  'However , this approach has a serious problem in that donor organs maintain healthy conditions only during short-term storage .',
  'Establishing fair allocation priorities is a serious problem in organ transplantation .',
  'Shortage of donor organs is a serious problem for transplantation medicine .',
  'A shortage of organ donors for transplantation has become a serious problem throughout the world .',
  'Waitlist mortality due to donor shortage for lung transplantation is a serious problem worldwide .',
  'The small number of organs available for transplant poses a serious problem .',
  'A severe problem is the the scarcity of suitable donors for the very low weight children who are candidates for LSBT .',
  'Turkey is one of the countries facing a serious organ shortage problem , with thousands of patients with end-stage organ failure .',
  'A severe shortage of suitable allografts is a long-standing and worldwide problem for patients who are waiting for organ transplantation .',
  'However , the shortage of donor skin tissues is a serious problem .',
  'However , when a severe health problem occurs in a donor while the recipient has already received a conditioning regimen , hematologists have to find the best solutions for the recipient , while the team in charge of the donor has to find the best medical solutions for the donor .',
  'A shortage of donors poses a serious problem for organ transplantation around the world .',
  'However , the imbalance between the supply and the demand for human organs is a serious problem in modern transplantology .',
  'The recent increase of the number of unidentified cadavers has become a serious problem throughout the world .',
  'The shortage of organ donors is a serious problem in Japan .',
  'The shortage of donors has become a serious problem .',
  'Organ shortages are a serious problem , even in the United States .',
  'To increase the number of available pulmonary grafts , we have tried various strategies , such as active use of marginal donors , careful donor management , and development of new preservation solutions , but the shortage of brain-dead donors remains a serious problem .'],
 'donors': ["The loss or deficiency of a tissue or organ is a serious health problem and severely affects the patients ' quality of life .",
  'The organ shortage for transplantation , the principal factor that increases waiting lists , has become a serious public health problem .',
  'The persisting organ shortage remains a serious problem .',
  'The disproportion between the large organ demand and the low number of transplantations performed represents a serious public health problem worldwide .',
  'There is a severe shortage of human organs available for transplantation and xenotransplantation - use of animal organs has long been suggested to overcome this problem .',
  'In spite of the recent advances in transplantation techniques , donor organ shortage remains a serious problem .',
  'The shortage of organ donors has become a serious problem in modern medicine .',
  'The lack of donor grafts is a severe problem in transplantation medicine .',
  'The shortage of human organs for transplantation is a devastating medical problem .',
  'In hair transplantation , the availability of a limited number of grafts for a conventional transplantation can pose a serious problem .',
  'The shortage of organs and tissues for transplantation is considered a serious global problem .',
  'However , this approach has a serious problem in that donor organs maintain healthy conditions only during short-term storage .',
  'Establishing fair allocation priorities is a serious problem in organ transplantation .',
  'Shortage of donor organs is a serious problem for transplantation medicine .',
  'A shortage of organ donors for transplantation has become a serious problem throughout the world .',
  'Waitlist mortality due to donor shortage for lung transplantation is a serious problem worldwide .',
  'The small number of organs available for transplant poses a serious problem .',
  'A severe problem is the the scarcity of suitable donors for the very low weight children who are candidates for LSBT .',
  'Turkey is one of the countries facing a serious organ shortage problem , with thousands of patients with end-stage organ failure .',
  'A severe shortage of suitable allografts is a long-standing and worldwide problem for patients who are waiting for organ transplantation .',
  'However , the shortage of donor skin tissues is a serious problem .',
  'However , when a severe health problem occurs in a donor while the recipient has already received a conditioning regimen , hematologists have to find the best solutions for the recipient , while the team in charge of the donor has to find the best medical solutions for the donor .',
  'A shortage of donors poses a serious problem for organ transplantation around the world .',
  'However , the imbalance between the supply and the demand for human organs is a serious problem in modern transplantology .',
  'The recent increase of the number of unidentified cadavers has become a serious problem throughout the world .',
  'The shortage of organ donors is a serious problem in Japan .',
  'The shortage of donors has become a serious problem .',
  'Organ shortages are a serious problem , even in the United States .',
  'To increase the number of available pulmonary grafts , we have tried various strategies , such as active use of marginal donors , careful donor management , and development of new preservation solutions , but the shortage of brain-dead donors remains a serious problem .'],
 'graft': ['Recurrent hepatocellular carcinoma after living donor liver transplantation : a preventable problem or an acceptable risk ?',
  'Graft loss because of hepatitis C virus recurrence is a serious problem after liver transplantation ( LT ) , and the response to pegylated interferon ( PEG-IFN ) and ribavirin ( RBV ) is poor .',
  'Graft loss due to hepatitis C ( HCV ) recurrence is a serious problem after LT .',
  'Hepatitis C virus ( HCV ) recurrence after orthotopic liver transplantation ( OLT ) remains a serious problem in the clinical management of post-oLT patients .',
  'We conclude that HCV infection is a serious health problem among kidney transplant recipients and it significantly affects the graft outcome .',
  'In the liver transplant ( LT ) setting , these regimens are expected to have an important effect , because graft loss due to HCV recurrence is a serious problem after LT .',
  'Recurrent hepatitis C infection in the posttransplant setting is a serious problem .',
  'Hepatitis C virus ( HCV ) recurrence is a serious problem after orthotopic liver transplantation ( OLT ) .',
  'Hepatitis C virus ( HCV ) recurrence after liver transplantation ( LT ) used to be a serious problem in the era of interferon-based treatment .',
  'However , the recurrence of HCC after transplantation remains a serious problem that affects about 20 % of post-transplant cases .',
  'Hepatitis C recurrence after liver transplantation is a serious problem , leading to increased graft loss and morbidity in some individuals .',
  'Recurrent hepatitis C after liver transplantation is a serious problem faced by liver transplant recipients .',
  'Recurrent hepatitis C virus ( HCV ) has been a serious problem after liver transplantation ( LT ) .'],
 'transplant': ['Recurrent hepatocellular carcinoma after living donor liver transplantation : a preventable problem or an acceptable risk ?',
  'Graft loss because of hepatitis C virus recurrence is a serious problem after liver transplantation ( LT ) , and the response to pegylated interferon ( PEG-IFN ) and ribavirin ( RBV ) is poor .',
  'Graft loss due to hepatitis C ( HCV ) recurrence is a serious problem after LT .',
  'Hepatitis C virus ( HCV ) recurrence after orthotopic liver transplantation ( OLT ) remains a serious problem in the clinical management of post-oLT patients .',
  'We conclude that HCV infection is a serious health problem among kidney transplant recipients and it significantly affects the graft outcome .',
  'In the liver transplant ( LT ) setting , these regimens are expected to have an important effect , because graft loss due to HCV recurrence is a serious problem after LT .',
  'Recurrent hepatitis C infection in the posttransplant setting is a serious problem .',
  'Hepatitis C virus ( HCV ) recurrence is a serious problem after orthotopic liver transplantation ( OLT ) .',
  'Hepatitis C virus ( HCV ) recurrence after liver transplantation ( LT ) used to be a serious problem in the era of interferon-based treatment .',
  'However , the recurrence of HCC after transplantation remains a serious problem that affects about 20 % of post-transplant cases .',
  'Hepatitis C recurrence after liver transplantation is a serious problem , leading to increased graft loss and morbidity in some individuals .',
  'Recurrent hepatitis C after liver transplantation is a serious problem faced by liver transplant recipients .',
  'Recurrent hepatitis C virus ( HCV ) has been a serious problem after liver transplantation ( LT ) .'],
 'interferon': ['Recurrent hepatocellular carcinoma after living donor liver transplantation : a preventable problem or an acceptable risk ?',
  'Graft loss because of hepatitis C virus recurrence is a serious problem after liver transplantation ( LT ) , and the response to pegylated interferon ( PEG-IFN ) and ribavirin ( RBV ) is poor .',
  'Graft loss due to hepatitis C ( HCV ) recurrence is a serious problem after LT .',
  'Hepatitis C virus ( HCV ) recurrence after orthotopic liver transplantation ( OLT ) remains a serious problem in the clinical management of post-oLT patients .',
  'We conclude that HCV infection is a serious health problem among kidney transplant recipients and it significantly affects the graft outcome .',
  'In the liver transplant ( LT ) setting , these regimens are expected to have an important effect , because graft loss due to HCV recurrence is a serious problem after LT .',
  'Recurrent hepatitis C infection in the posttransplant setting is a serious problem .',
  'Hepatitis C virus ( HCV ) recurrence is a serious problem after orthotopic liver transplantation ( OLT ) .',
  'Hepatitis C virus ( HCV ) recurrence after liver transplantation ( LT ) used to be a serious problem in the era of interferon-based treatment .',
  'However , the recurrence of HCC after transplantation remains a serious problem that affects about 20 % of post-transplant cases .',
  'Hepatitis C recurrence after liver transplantation is a serious problem , leading to increased graft loss and morbidity in some individuals .',
  'Recurrent hepatitis C after liver transplantation is a serious problem faced by liver transplant recipients .',
  'Recurrent hepatitis C virus ( HCV ) has been a serious problem after liver transplantation ( LT ) .'],
 'mycotoxins': ['Mycotoxin contamination in pet food poses a serious health threat to pets , causing an emotional and economical concern to the pet owners .',
  'The occurrence of mycotoxin-producing moulds in animal feed is a severe problem since the quality of the feed is reduced and thereby both animal and human health can be affected .',
  'The contamination of cereals with mycotoxins has been a serious problem in Balkan communities .',
  'Stachybotryotoxicosis , one of the oldest mycotoxicoses known , and a serious problem in Middle Europe ( Gy . Danko , Magy . Allatorv . Lapja 31:226 - 232 , 1976 ) , is believed to be caused by macrocyclic trichothecene toxins produced by Stachybotrys atra ( R. M. Eppley , in Rodricks et al. , ed . , Mycotoxins in Human and Animal Health , p. 285 - 293 , 1977 ) .',
  'Contamination of food with mycotoxins and the associated possibilities of human intoxication is a serious problem in Africa .',
  'Ochratoxin A ( OA ) is a toxic isocoumarin derivative released by various species of mold which grow on grain , coffee , and nuts , representing a serious worldwide health problem .',
  'In countries with a hot climate the mycotoxin citrinin represents a serious problem in fungal food-poisoning .',
  'Contamination of feed with mycotoxins represents a serious worldwide problem concerning animal health and related economic losses .',
  'Human exposure to these mycotoxins is a serious problem especially in developing countries where hot and humid climates favor the fungal growth and where food storage conditions are poor and lack of regulatory limits enforcement .',
  'Contamination of food/feedstuffs by mycotoxins is a serious problem worldwide , causing severe economic losses and serious health problems in animals/humans .',
  'The presence of mycotoxins in food represents a severe threat for public health and welfare , and poses relevant research challenges in the food toxicology field .',
  'Mycotoxin contamination in agro-food systems has been a serious concern over the last few decades in China , where the Ministry of Health has set maximum limits for mycotoxins in different agro-products .',
  'Mycotoxins especially aflatoxins in cattle feed and their consequential presence in milk and milk products is a serious concern world over as they are reported carcinogens .',
  'Hundreds of potentially toxic mycotoxins have been already identified and are considered a serious problem in agriculture , animal husbandry , and public health .',
  'Οchratoxin A ( OTA ) is a carcinogenic mycotoxin produced by A. carbonarius that constitutes a severe problem for viticulture .',
  'Mycotoxin contamination of foods and feeds represent a serious problem worldwide .',
  'Mycotoxin contamination of crops is a serious problem throughout the world because of its impact on human and animal health as well as economy .',
  'Patulin , a potent mycotoxin , contaminates fruits and derived products worldwide , and is a serious health concern .'],
 'mycotoxin': ['Mycotoxin contamination in pet food poses a serious health threat to pets , causing an emotional and economical concern to the pet owners .',
  'The occurrence of mycotoxin-producing moulds in animal feed is a severe problem since the quality of the feed is reduced and thereby both animal and human health can be affected .',
  'The contamination of cereals with mycotoxins has been a serious problem in Balkan communities .',
  'Stachybotryotoxicosis , one of the oldest mycotoxicoses known , and a serious problem in Middle Europe ( Gy . Danko , Magy . Allatorv . Lapja 31:226 - 232 , 1976 ) , is believed to be caused by macrocyclic trichothecene toxins produced by Stachybotrys atra ( R. M. Eppley , in Rodricks et al. , ed . , Mycotoxins in Human and Animal Health , p. 285 - 293 , 1977 ) .',
  'Contamination of food with mycotoxins and the associated possibilities of human intoxication is a serious problem in Africa .',
  'Ochratoxin A ( OA ) is a toxic isocoumarin derivative released by various species of mold which grow on grain , coffee , and nuts , representing a serious worldwide health problem .',
  'In countries with a hot climate the mycotoxin citrinin represents a serious problem in fungal food-poisoning .',
  'Contamination of feed with mycotoxins represents a serious worldwide problem concerning animal health and related economic losses .',
  'Human exposure to these mycotoxins is a serious problem especially in developing countries where hot and humid climates favor the fungal growth and where food storage conditions are poor and lack of regulatory limits enforcement .',
  'Contamination of food/feedstuffs by mycotoxins is a serious problem worldwide , causing severe economic losses and serious health problems in animals/humans .',
  'The presence of mycotoxins in food represents a severe threat for public health and welfare , and poses relevant research challenges in the food toxicology field .',
  'Mycotoxin contamination in agro-food systems has been a serious concern over the last few decades in China , where the Ministry of Health has set maximum limits for mycotoxins in different agro-products .',
  'Mycotoxins especially aflatoxins in cattle feed and their consequential presence in milk and milk products is a serious concern world over as they are reported carcinogens .',
  'Hundreds of potentially toxic mycotoxins have been already identified and are considered a serious problem in agriculture , animal husbandry , and public health .',
  'Οchratoxin A ( OTA ) is a carcinogenic mycotoxin produced by A. carbonarius that constitutes a severe problem for viticulture .',
  'Mycotoxin contamination of foods and feeds represent a serious problem worldwide .',
  'Mycotoxin contamination of crops is a serious problem throughout the world because of its impact on human and animal health as well as economy .',
  'Patulin , a potent mycotoxin , contaminates fruits and derived products worldwide , and is a serious health concern .'],
 'falciparum': ['Since the sixties , the emergence of malarial parasites resistant to the most potent anti-malarials has posed a serious problem to the therapy of malaria .',
  'Drug resistant P. falciparum in Nigeria constitutes a serious problem to malaria chemotherapy .',
  'Malaria is a leading cause of death in developing countries , and the emergence of strains resistant to the main therapeutic agent , chloroquine , has become a serious problem .',
  'The recent detection of clinical Artemisinin ( ART ) resistance manifested as delayed parasite clearance in the Cambodia-Thailand border area raises a serious concern .',
  'Drug resistance to anti-malarial compounds remains a serious problem , with resistance to newer pharmaceuticals developing at an alarming rate .',
  'The spread of chloroquine resistance poses a serious problem in Africa , where falciparum malaria transmission is the highest in the world .',
  'The recent reports of artemisinin ( ART ) resistance in the Thai-Cambodian border area raise a serious concern on the long-term efficacy of ARTs .',
  'Drug resistance in Plasmodium falciparum is a serious problem in most endemic areas .',
  "Falciparum malaria represents a serious and an increasing world public health problem due to the acquired parasite 's resistance to the most available drugs .",
  'In Colombia , Plasmodium resistance to antimalarials such as chloroquine and antifolates is a serious problem .',
  'Drug resistance is a serious problem in malaria , and prospects for new drugs are not optimistic .',
  'Chloroquine resistance represents a severe problem both for prophylaxis and treatment of malaria .',
  'The spread of resistance in Plasmodium falciparum to chloroquine , the most useful of these drugs , has been a serious problem since the 1960s , and the resistant strains show various degrees of cross-resistance to other drugs .',
  'The rising emergence of drug resistance towards the once effective artemisinin combination therapies ( ACTs ) has become a serious concern and warrants more robust drug development strategies , with the objective of eradicating malaria infections .',
  'Malaria remains a serious health problem because resistance develops to all currently used drugs when their parasite targets mutate .',
  'The resistance of Plasmodium spp . to currently used drugs has become a serious problem and efforts are being directed in obtaining new drugs with different structural features .',
  'Chloroquine-resistant falciparum malaria is a serious problem in much of sub-Saharan Africa .',
  'The emergence and spread of Plasmodium falciparum parasite resistant to sulfadoxine and pyrimethamine ( SP ) poses a serious public health problem .',
  'Increasing parasite resistance to nearly all available antimalarial drugs becomes a serious problem to human health and necessitates the need to continue the search for new effective drugs .',
  'The malaria parasite resistance to the existing drugs is a serious problem to the currently used antimalarials and , thus , highlights the urgent need to develop new and effective anti-malarial molecules .',
  'This raises a serious concern on the long-term efficacy of artemisinin-based combination therapies , as these combination therapies currently constitute the last effective and most tolerable treatment for multidrug-resistant Plasmodium falciparum .',
  'Malaria is a life-threatening disease and , what is more , the resistance to available antimalarial drugs is a recurring problem . The resistance of',
  'For this reason , the increasing prevalence of strains of Plasmodium falciparum resistant to chloroquine and other antimalarial drugs poses a serious problem for control of malaria .'],
 'chloroquine': ['Since the sixties , the emergence of malarial parasites resistant to the most potent anti-malarials has posed a serious problem to the therapy of malaria .',
  'Drug resistant P. falciparum in Nigeria constitutes a serious problem to malaria chemotherapy .',
  'Malaria is a leading cause of death in developing countries , and the emergence of strains resistant to the main therapeutic agent , chloroquine , has become a serious problem .',
  'The recent detection of clinical Artemisinin ( ART ) resistance manifested as delayed parasite clearance in the Cambodia-Thailand border area raises a serious concern .',
  'Drug resistance to anti-malarial compounds remains a serious problem , with resistance to newer pharmaceuticals developing at an alarming rate .',
  'The spread of chloroquine resistance poses a serious problem in Africa , where falciparum malaria transmission is the highest in the world .',
  'The recent reports of artemisinin ( ART ) resistance in the Thai-Cambodian border area raise a serious concern on the long-term efficacy of ARTs .',
  'Drug resistance in Plasmodium falciparum is a serious problem in most endemic areas .',
  "Falciparum malaria represents a serious and an increasing world public health problem due to the acquired parasite 's resistance to the most available drugs .",
  'In Colombia , Plasmodium resistance to antimalarials such as chloroquine and antifolates is a serious problem .',
  'Drug resistance is a serious problem in malaria , and prospects for new drugs are not optimistic .',
  'Chloroquine resistance represents a severe problem both for prophylaxis and treatment of malaria .',
  'The spread of resistance in Plasmodium falciparum to chloroquine , the most useful of these drugs , has been a serious problem since the 1960s , and the resistant strains show various degrees of cross-resistance to other drugs .',
  'The rising emergence of drug resistance towards the once effective artemisinin combination therapies ( ACTs ) has become a serious concern and warrants more robust drug development strategies , with the objective of eradicating malaria infections .',
  'Malaria remains a serious health problem because resistance develops to all currently used drugs when their parasite targets mutate .',
  'The resistance of Plasmodium spp . to currently used drugs has become a serious problem and efforts are being directed in obtaining new drugs with different structural features .',
  'Chloroquine-resistant falciparum malaria is a serious problem in much of sub-Saharan Africa .',
  'The emergence and spread of Plasmodium falciparum parasite resistant to sulfadoxine and pyrimethamine ( SP ) poses a serious public health problem .',
  'Increasing parasite resistance to nearly all available antimalarial drugs becomes a serious problem to human health and necessitates the need to continue the search for new effective drugs .',
  'The malaria parasite resistance to the existing drugs is a serious problem to the currently used antimalarials and , thus , highlights the urgent need to develop new and effective anti-malarial molecules .',
  'This raises a serious concern on the long-term efficacy of artemisinin-based combination therapies , as these combination therapies currently constitute the last effective and most tolerable treatment for multidrug-resistant Plasmodium falciparum .',
  'Malaria is a life-threatening disease and , what is more , the resistance to available antimalarial drugs is a recurring problem . The resistance of',
  'For this reason , the increasing prevalence of strains of Plasmodium falciparum resistant to chloroquine and other antimalarial drugs poses a serious problem for control of malaria .'],
 'plasmodium': ['Since the sixties , the emergence of malarial parasites resistant to the most potent anti-malarials has posed a serious problem to the therapy of malaria .',
  "Malaria infection during pregnancy is a serious health problem in most of the world 's tropical regions .",
  'Anaemia is a serious problem in pregnancy in malaria-endemic countries .',
  'Connected with perinatal diseases as well as gastrointestinal and respiratory infections malaria has been still a serious health problem of that region .',
  'Drug resistant P. falciparum in Nigeria constitutes a serious problem to malaria chemotherapy .',
  'Malaria is a leading cause of death in developing countries , and the emergence of strains resistant to the main therapeutic agent , chloroquine , has become a serious problem .',
  'The recent detection of clinical Artemisinin ( ART ) resistance manifested as delayed parasite clearance in the Cambodia-Thailand border area raises a serious concern .',
  'Drug resistance to anti-malarial compounds remains a serious problem , with resistance to newer pharmaceuticals developing at an alarming rate .',
  'The spread of chloroquine resistance poses a serious problem in Africa , where falciparum malaria transmission is the highest in the world .',
  'Malaria in pregnancy is a serious health problem that contributes greatly to maternal morbidity and mortality .',
  'The recent reports of artemisinin ( ART ) resistance in the Thai-Cambodian border area raise a serious concern on the long-term efficacy of ARTs .',
  'Drug resistance in Plasmodium falciparum is a serious problem in most endemic areas .',
  "Falciparum malaria represents a serious and an increasing world public health problem due to the acquired parasite 's resistance to the most available drugs .",
  'In Colombia , Plasmodium resistance to antimalarials such as chloroquine and antifolates is a serious problem .',
  'Drug resistance is a serious problem in malaria , and prospects for new drugs are not optimistic .',
  'Chloroquine resistance represents a severe problem both for prophylaxis and treatment of malaria .',
  'The spread of resistance in Plasmodium falciparum to chloroquine , the most useful of these drugs , has been a serious problem since the 1960s , and the resistant strains show various degrees of cross-resistance to other drugs .',
  'Malaria during pregnancy remains a serious public health problem , with substantial risks for the mother , her foetus and the newborn .',
  'The rising emergence of drug resistance towards the once effective artemisinin combination therapies ( ACTs ) has become a serious concern and warrants more robust drug development strategies , with the objective of eradicating malaria infections .',
  'Malaria remains a serious health problem because resistance develops to all currently used drugs when their parasite targets mutate .',
  'The resistance of Plasmodium spp . to currently used drugs has become a serious problem and efforts are being directed in obtaining new drugs with different structural features .',
  'Malaria in pregnancy remains a serious public health problem in the Republic of Congo despite the implementation of intermittent preventive treatment with sulfadoxine-pyrimethamine ( IPTp-SP ) in 2006 .',
  'Chloroquine-resistant falciparum malaria is a serious problem in much of sub-Saharan Africa .',
  'Placental malaria is a serious problem in sub-Saharan Africa .',
  'The emergence and spread of Plasmodium falciparum parasite resistant to sulfadoxine and pyrimethamine ( SP ) poses a serious public health problem .',
  'Increasing parasite resistance to nearly all available antimalarial drugs becomes a serious problem to human health and necessitates the need to continue the search for new effective drugs .',
  'Malaria during pregnancy remains a serious public health problem .',
  'In Colombia , with higher frequency of Plasmodium vivax over Plasmodium falciparum infection , recent reports confirmed gestational malaria as a serious public health problem .',
  'The malaria parasite resistance to the existing drugs is a serious problem to the currently used antimalarials and , thus , highlights the urgent need to develop new and effective anti-malarial molecules .',
  'This raises a serious concern on the long-term efficacy of artemisinin-based combination therapies , as these combination therapies currently constitute the last effective and most tolerable treatment for multidrug-resistant Plasmodium falciparum .',
  'Placental malaria ( PM ) remains a severe public health problem in areas of high malaria transmission .',
  'Malaria during pregnancy remains a serious public health problem .',
  'Malaria is a life-threatening disease and , what is more , the resistance to available antimalarial drugs is a recurring problem . The resistance of',
  'For this reason , the increasing prevalence of strains of Plasmodium falciparum resistant to chloroquine and other antimalarial drugs poses a serious problem for control of malaria .'],
 'artemisinin': ['Since the sixties , the emergence of malarial parasites resistant to the most potent anti-malarials has posed a serious problem to the therapy of malaria .',
  'Drug resistant P. falciparum in Nigeria constitutes a serious problem to malaria chemotherapy .',
  'Malaria is a leading cause of death in developing countries , and the emergence of strains resistant to the main therapeutic agent , chloroquine , has become a serious problem .',
  'The recent detection of clinical Artemisinin ( ART ) resistance manifested as delayed parasite clearance in the Cambodia-Thailand border area raises a serious concern .',
  'Drug resistance to anti-malarial compounds remains a serious problem , with resistance to newer pharmaceuticals developing at an alarming rate .',
  'The spread of chloroquine resistance poses a serious problem in Africa , where falciparum malaria transmission is the highest in the world .',
  'The recent reports of artemisinin ( ART ) resistance in the Thai-Cambodian border area raise a serious concern on the long-term efficacy of ARTs .',
  'Drug resistance in Plasmodium falciparum is a serious problem in most endemic areas .',
  "Falciparum malaria represents a serious and an increasing world public health problem due to the acquired parasite 's resistance to the most available drugs .",
  'In Colombia , Plasmodium resistance to antimalarials such as chloroquine and antifolates is a serious problem .',
  'Drug resistance is a serious problem in malaria , and prospects for new drugs are not optimistic .',
  'Chloroquine resistance represents a severe problem both for prophylaxis and treatment of malaria .',
  'The spread of resistance in Plasmodium falciparum to chloroquine , the most useful of these drugs , has been a serious problem since the 1960s , and the resistant strains show various degrees of cross-resistance to other drugs .',
  'The rising emergence of drug resistance towards the once effective artemisinin combination therapies ( ACTs ) has become a serious concern and warrants more robust drug development strategies , with the objective of eradicating malaria infections .',
  'Malaria remains a serious health problem because resistance develops to all currently used drugs when their parasite targets mutate .',
  'The resistance of Plasmodium spp . to currently used drugs has become a serious problem and efforts are being directed in obtaining new drugs with different structural features .',
  'Chloroquine-resistant falciparum malaria is a serious problem in much of sub-Saharan Africa .',
  'The emergence and spread of Plasmodium falciparum parasite resistant to sulfadoxine and pyrimethamine ( SP ) poses a serious public health problem .',
  'Increasing parasite resistance to nearly all available antimalarial drugs becomes a serious problem to human health and necessitates the need to continue the search for new effective drugs .',
  'The malaria parasite resistance to the existing drugs is a serious problem to the currently used antimalarials and , thus , highlights the urgent need to develop new and effective anti-malarial molecules .',
  'This raises a serious concern on the long-term efficacy of artemisinin-based combination therapies , as these combination therapies currently constitute the last effective and most tolerable treatment for multidrug-resistant Plasmodium falciparum .',
  'Malaria is a life-threatening disease and , what is more , the resistance to available antimalarial drugs is a recurring problem . The resistance of',
  'For this reason , the increasing prevalence of strains of Plasmodium falciparum resistant to chloroquine and other antimalarial drugs poses a serious problem for control of malaria .'],
 'harm': ['Nonsuicidal self-injury ( NSSI ) is a serious public health concern among adolescents .',
  'Self-harm thoughts and behaviours ( SHTBs ) are a serious public health concern in young people .',
  'Self-injurious behaviors in adolescence are a serious public health concern .',
  'Adolescent suicide is a serious public health problem , and non-suicidal self-injury ( NSSI ) is both highly comorbid with suicidality among adolescents and a significant predictor of suicide attempts ( SAs ) in adolescents .',
  'Self-injurious behavior ( e.g. , nonsuicidal self-injury , suicide attempts ) is a serious public health concern .',
  'Non-suicidal self-injury ( NSSI ) is a serious public health concern facing adolescents and young adults worldwide .',
  'Nonsuicidal self-injury in men : a serious problem that has been overlooked for too long .',
  'Self-harm is a serious risk factor for suicide , a major public health concern , and a significant burden on the NHS .',
  'Adolescent self-harm is recognized as a serious public health problem ; however , there is little reliable comparative data on its prevalence or characteristics , or on the extent of help-seeking for self-harm .',
  'Despite recent advances in the understanding and treatment of self-harm , poor engagement with therapy remains a serious problem .',
  'Self harm is a serious public health problem worldwide .',
  'Self-harm represents a serious and pathological behavior that occurs most notably during adolescent years and currently seems to be a problem that is on the increase .',
  'Self-harm remains a serious public health concern , not least because of its strong link with suicide .',
  'Non-suicidal self-injury ( NSSI ) is a serious clinical problem that is common in adolescents .',
  'Although non-suicidal self-injury ( nssi ) is a serious health concern among prisoners worldwide , no empirical data on this issue are currently available specifically for Belgium.<br/ > AIM : To investigate the prevalence rates of , and risk factors for , nssi in Flemish prisons.<br/ > METHOD : A cross-sectional study based on a representative sample of 1326 prisoners ( 1203 men and 123 women ) , randomly selected from 15 Flemish prisons.<br/ > RESULTS : Overall , 17.3 % of prisoners self-reported a lifetime history of nssi .',
  'Self-inflicted injury ( SII ) in adolescence is a serious public health concern that portends prospective vulnerability to internalizing and externalizing psychopathology , borderline personality development , suicide attempts , and suicide .',
  'Non-suicidal self-injury ( NSSI ) is a serious public health concern in adolescents .',
  'Nonsuicidal self-injury ( NSSI ) is a serious and prevalent problem within the adolescent population .',
  'Self-harm in young people continues to be a serious concern for health services globally .',
  'Self-harm remains a serious public health concern ; however , identifying adolescents at risk is challenging .',
  'Non-suicidal self-injury ( NSSI ) is a serious public health concern and remains poorly understood .',
  'Recently self-injurious behavior including wrist-cutting among youth has been a serious problem in Japan .',
  'Self-injury is a dangerous and pervasive behavior problem among adolescents .',
  'Self-harm is a severe health problem worldwide and in particular in clinical settings .',
  'Nonsuicidal self-injury ( NSSI ) is a serious public health problem .'],
 'prisoners': ['Nonsuicidal self-injury ( NSSI ) is a serious public health concern among adolescents .',
  'Self-harm thoughts and behaviours ( SHTBs ) are a serious public health concern in young people .',
  'Self-injurious behaviors in adolescence are a serious public health concern .',
  'Adolescent suicide is a serious public health problem , and non-suicidal self-injury ( NSSI ) is both highly comorbid with suicidality among adolescents and a significant predictor of suicide attempts ( SAs ) in adolescents .',
  'Self-injurious behavior ( e.g. , nonsuicidal self-injury , suicide attempts ) is a serious public health concern .',
  'Non-suicidal self-injury ( NSSI ) is a serious public health concern facing adolescents and young adults worldwide .',
  'Nonsuicidal self-injury in men : a serious problem that has been overlooked for too long .',
  'Self-harm is a serious risk factor for suicide , a major public health concern , and a significant burden on the NHS .',
  'Adolescent self-harm is recognized as a serious public health problem ; however , there is little reliable comparative data on its prevalence or characteristics , or on the extent of help-seeking for self-harm .',
  'Despite recent advances in the understanding and treatment of self-harm , poor engagement with therapy remains a serious problem .',
  'Self harm is a serious public health problem worldwide .',
  'Self-harm represents a serious and pathological behavior that occurs most notably during adolescent years and currently seems to be a problem that is on the increase .',
  'Self-harm remains a serious public health concern , not least because of its strong link with suicide .',
  'Non-suicidal self-injury ( NSSI ) is a serious clinical problem that is common in adolescents .',
  'Although non-suicidal self-injury ( nssi ) is a serious health concern among prisoners worldwide , no empirical data on this issue are currently available specifically for Belgium.<br/ > AIM : To investigate the prevalence rates of , and risk factors for , nssi in Flemish prisons.<br/ > METHOD : A cross-sectional study based on a representative sample of 1326 prisoners ( 1203 men and 123 women ) , randomly selected from 15 Flemish prisons.<br/ > RESULTS : Overall , 17.3 % of prisoners self-reported a lifetime history of nssi .',
  'Self-inflicted injury ( SII ) in adolescence is a serious public health concern that portends prospective vulnerability to internalizing and externalizing psychopathology , borderline personality development , suicide attempts , and suicide .',
  'Non-suicidal self-injury ( NSSI ) is a serious public health concern in adolescents .',
  'Nonsuicidal self-injury ( NSSI ) is a serious and prevalent problem within the adolescent population .',
  'Self-harm in young people continues to be a serious concern for health services globally .',
  'Self-harm remains a serious public health concern ; however , identifying adolescents at risk is challenging .',
  'Non-suicidal self-injury ( NSSI ) is a serious public health concern and remains poorly understood .',
  'Recently self-injurious behavior including wrist-cutting among youth has been a serious problem in Japan .',
  'Self-injury is a dangerous and pervasive behavior problem among adolescents .',
  'Self-harm is a severe health problem worldwide and in particular in clinical settings .',
  'Nonsuicidal self-injury ( NSSI ) is a serious public health problem .'],
 'syphilis': ['Syphilis is a multistage sexually transmitted disease that remains a serious public health concern worldwide .',
  'Syphilis continues to be a serious public health problem worldwide , even if it is a controllable disease due to diagnostic tests and effective and accessible treatment .',
  'A serious problem of " gravidic syphilis " suggests the need for Public Health preventive action .',
  'Congenital syphilis is the oldest recognized congenital infection and still represents a serious healthcare problem in the 21st century .',
  'Congenital syphilis is a preventable disease and treatable infection in the modern world , but we are still met with challenges in its eradication .',
  'Persistent syphilis in this population of FSWs is a serious public health concern .',
  'The infection rate of syphilis in China has increased dramatically in recent decades , becoming a serious public health concern .',
  'Brazil has reported an increase in the incidence of both gestational and congenital syphilis , posing a serious public health problem in the country .',
  'Syphilis poses a serious health problem in many developing countries and in some areas of North America and Europe , especially Eastern Europe .',
  'This study illustrates that , despite being a preventable infection , syphilis remains a public health problem .',
  'Syphilis transmission among IDUs in Los Angeles County remains a serious public health concern , particularly among IDUs who engage in trading of sex for money or drugs .',
  'In Morocco , neurosyphilis is a serious public health problem .',
  'Congenital syphilis is considered a severe public health problem because it accounts for approximately 40 % of the perinatal mortality rates , 25 % of stillbirths , and 14 % of neonatal deaths , in addition to causing severe consequences for the fetus .'],
 'lead': ['Childhood lead poisoning is a serious public health problem with long-term adverse effects .',
  'A major source of childhood lead poisoning , still a serious problem in the United States , is paint .',
  'Due to its high mobility , high stability and potential for bioaccumulation , the risks of PBZ to the health of organisms and ecological systems have become a serious concern .',
  'Exposure to lead ( Pb ) in environmental and occupational settings continues to be a serious public health problem and may pose an elevated risk of genetic damage .',
  'The transfer of Pb from the soil to crops is a serious food hygiene security problem in China because of industrial , agricultural , and historical contamination .',
  'Lead exposure among children is a serious health problem affecting virtually every system in their bodies .',
  'Lead contamination is widespread across China , posing a serious public health concern .',
  'The continued occurrence of occupational lead overexposure and lead poisoning in the United States remains a serious problem despite awareness of its adverse health effects .',
  'Both occupational and environmental exposures to lead remain a serious problem in many developing and industrialising countries , as well as in some developed countries .',
  'Environmental lead exposure remains a serious concern for the growth and development of children .',
  'With the wide application of lead acid battery , spent lead acid battery has become a serious problem to environmental protection and human health .',
  'Complex analysis proves environmental pollution with lead and its compounds to be a serious problem for urban territories of Russian Federation , so immediate activities of authorities in charge are required .',
  'Lead ( Pb ) poisoning has been found to be a serious problem for waterfowl in some southern European countries , but few studies have been conducted in Spain .',
  'CRT funnel glass containing lead has become a serious environmental problem facing the whole world .',
  'We conclude that lead poisoning is a serious problem in Al Jahra , Kuwait , and that a comprehensive programme for screening and health education are urgently needed to avoid the irreversible effects of lead toxicity .',
  "Workers ' blood lead levels were brought down from 114.4 , 110.0 and 120.6 mg/dL with treatment of D-penicillamine to 40 mg/dL. It may be concluded that lead poisoning is a preventable public health problem that particularly affects the industrial workers in small lead-based units .",
  'Environmental lead ( Pb ) is a serious public health problem .',
  'Despite the well-known toxicity and the efforts to control its exposure , lead still has a serious health concern , particularly in young ages .',
  'Lead ( Pb(II ) ) exposure from drinking water consumption is a serious concern due to its negative health effect on human physiology .',
  'Preventive measures in Central Europe were successful in suppressing both occupational and environmental lead exposure so that they did not constitute a severe public health problem .',
  'Both occupational and environmental exposures to lead remain a serious problem in many developing and industrializing countries .',
  'Lead ( Pb ) contamination of soil is a serious environmental problem , adversely affecting ecosystems , globally .',
  'Child exposure to lead from informal used lead-acid battery ( ULAB ) recycling operations is a serious environmental health problem , particularly in developing countries .',
  'Pb pollution caused by shooting sport activities is a serious environmental problem that has increased considerably in recent decades .',
  'Blood lead levels ( BLL ) of children and adults have been decreasing recently almost all over the world , but a safety level for blood lead does not exist , and lead exposure is still a serious health problem especially for fetuses and children .',
  'Lead ( Pb ) is an environmental pollutant with a toxicity that is a serious public health problem .',
  'Soil contamination with lead ( Pb ) is a serious global concern , adversely affecting crop production .',
  'Lead poisoning is a preventable health problem .',
  'While leadpoisoning has been with mankind since the dawn of civilization , only in recent years this disease was recognized as a serious public health problem .',
  'Occupational exposure to lead fumes constitutes a serious problem in Egypt , since a considerable number of workers might be involved in its deleterious effect .',
  'During the past years , efforts have been made to deal with the Pb contaminated sediment in Xiawangang River in Hunan province , China , but it remains a serious problem since the smelting pollutants were accumulated .',
  'We conclude that lead exposure does not constitute a serious health problem in the area studied , since BPb levels found are far below the toxic limit and the prevalence of intoxication is similar to that reported in other studies conducted in other developed countries .',
  'Environmental lead pollution does not seem to be a serious problem in Taiwan .',
  'While lead poisoning among children is on the decline , it is still a serious health problem that affects an estimated 930,000 children between the ages of one and five .',
  'Asymptomatic Pb poisoning of children remains a serious public health problem in the United States .',
  'The results of the determinations indicate that exposure to lead continues to be a serious problem in Polish industry .',
  'We concluded that lead poisoning is still a serious threat to waterfowl in Japan and that there is considerable need for environmental improvement concerning this problem .',
  'Both occupational and environmental exposures to lead remain a serious problem in many developing and industrializing countries , as well as in some developed countries .',
  'The present data concerning Tarragona Province show that in relation to environmental health there is not a serious problem from lead contamination .',
  "Lead ( Pb ) pollution is a serious public health problem all over the world , it especially plays severe damage role in children 's health .",
  'Lead is an environmental toxicant , occupational and environmental exposures remain a serious problem in developing and industrializing countries .',
  'Lead (Pb)-poisoning is a serious public health concern and dogs have been useful as a sentinel-animal for Pb exposure of humans .',
  'Lead toxicity has become a serious public health concern all over the world .',
  'Exposure to lead hazards is a serious health concern for inner-city children .',
  'Lead ( Pb ) contamination in the air is a severe global problem , most notably in China .',
  'Both occupational and environmental exposures to lead remain a serious problem in many developing and industrializing countries and a public health problem of global dimensions .',
  'Prior calculations of the burden of disease from environmental lead exposure in low- \xa0 and middle-income countries ( LMICs ) have not included estimates of the burden from lead-contaminated sites because of a lack of exposure data , resulting in an underestimation of a serious public health problem .',
  'Currently , Pb pollution has become a severe environmental problem and filamentous fungi hold a promising potential for the treatment of Pb-containing wastewater .',
  'As one of the important contaminants in wastewater , Pb(II ) becomes a severe public health problem because of its non-biodegradable and persistent nature .',
  'Childhood lead poisoning is a serious public health concern worldwide .',
  'The presence of lead ( Pb ) in milk and its interaction with trace elements is a serious health concern .',
  'Lead intoxication is a serious occupational disease that constitutes a major public health problem .',
  'Lead (Pb)-based paints pose a serious health problem to people living in residential settings constructed prior to 1978 .',
  'Lead ( Pb ) toxicity has been a serious concern in industrialized societies because of its association with functional deficits in nervous , haematopoietic and renal systems .',
  'Childhood lead poisoning remains a serious public health problem for millions of American children .',
  'Lead ( Pb ) poisoning has always been a serious health concern , as it permanently damages the central nervous system .',
  'Lead contamination is a serious environmental problem with toxic effects in human .',
  'Lead ( Pb ) poisoning in raptors and water birds is a serious problem in many countries .',
  'The contamination of soil by lead ( Pb ) is a serious and widespread problem in China , especially in mining areas .',
  'Asymptomatic lead poisoning remains a serious public health problem in developed and developing countries .',
  'Therefore , Pb poisoning is still a serious problem in raptors in various areas of Japan due to accidental ingestion of materials containing Pb , especially Pb ammunition .',
  'Lead ( Pb ) pollution is a serious problem in the developing countries , especially in South Asia .',
  'Lead poisoning in children is a preventable public health problem that can adversely affect the developing nervous system and result in learning and behavior problems .',
  '[ Lead poisoning in children is a serious problem in the USA ] .'],
 'pb': ['Childhood lead poisoning is a serious public health problem with long-term adverse effects .',
  'A major source of childhood lead poisoning , still a serious problem in the United States , is paint .',
  'Due to its high mobility , high stability and potential for bioaccumulation , the risks of PBZ to the health of organisms and ecological systems have become a serious concern .',
  'Exposure to lead ( Pb ) in environmental and occupational settings continues to be a serious public health problem and may pose an elevated risk of genetic damage .',
  'The transfer of Pb from the soil to crops is a serious food hygiene security problem in China because of industrial , agricultural , and historical contamination .',
  'Lead exposure among children is a serious health problem affecting virtually every system in their bodies .',
  'Lead contamination is widespread across China , posing a serious public health concern .',
  'The continued occurrence of occupational lead overexposure and lead poisoning in the United States remains a serious problem despite awareness of its adverse health effects .',
  'Both occupational and environmental exposures to lead remain a serious problem in many developing and industrialising countries , as well as in some developed countries .',
  'Environmental lead exposure remains a serious concern for the growth and development of children .',
  'With the wide application of lead acid battery , spent lead acid battery has become a serious problem to environmental protection and human health .',
  'Complex analysis proves environmental pollution with lead and its compounds to be a serious problem for urban territories of Russian Federation , so immediate activities of authorities in charge are required .',
  'Lead ( Pb ) poisoning has been found to be a serious problem for waterfowl in some southern European countries , but few studies have been conducted in Spain .',
  'CRT funnel glass containing lead has become a serious environmental problem facing the whole world .',
  'We conclude that lead poisoning is a serious problem in Al Jahra , Kuwait , and that a comprehensive programme for screening and health education are urgently needed to avoid the irreversible effects of lead toxicity .',
  "Workers ' blood lead levels were brought down from 114.4 , 110.0 and 120.6 mg/dL with treatment of D-penicillamine to 40 mg/dL. It may be concluded that lead poisoning is a preventable public health problem that particularly affects the industrial workers in small lead-based units .",
  'Environmental lead ( Pb ) is a serious public health problem .',
  'Despite the well-known toxicity and the efforts to control its exposure , lead still has a serious health concern , particularly in young ages .',
  'Lead ( Pb(II ) ) exposure from drinking water consumption is a serious concern due to its negative health effect on human physiology .',
  'Preventive measures in Central Europe were successful in suppressing both occupational and environmental lead exposure so that they did not constitute a severe public health problem .',
  'Both occupational and environmental exposures to lead remain a serious problem in many developing and industrializing countries .',
  'Lead ( Pb ) contamination of soil is a serious environmental problem , adversely affecting ecosystems , globally .',
  'Child exposure to lead from informal used lead-acid battery ( ULAB ) recycling operations is a serious environmental health problem , particularly in developing countries .',
  'Pb pollution caused by shooting sport activities is a serious environmental problem that has increased considerably in recent decades .',
  'Blood lead levels ( BLL ) of children and adults have been decreasing recently almost all over the world , but a safety level for blood lead does not exist , and lead exposure is still a serious health problem especially for fetuses and children .',
  'Lead ( Pb ) is an environmental pollutant with a toxicity that is a serious public health problem .',
  'Soil contamination with lead ( Pb ) is a serious global concern , adversely affecting crop production .',
  'Lead poisoning is a preventable health problem .',
  'While leadpoisoning has been with mankind since the dawn of civilization , only in recent years this disease was recognized as a serious public health problem .',
  'Occupational exposure to lead fumes constitutes a serious problem in Egypt , since a considerable number of workers might be involved in its deleterious effect .',
  'During the past years , efforts have been made to deal with the Pb contaminated sediment in Xiawangang River in Hunan province , China , but it remains a serious problem since the smelting pollutants were accumulated .',
  'We conclude that lead exposure does not constitute a serious health problem in the area studied , since BPb levels found are far below the toxic limit and the prevalence of intoxication is similar to that reported in other studies conducted in other developed countries .',
  'Environmental lead pollution does not seem to be a serious problem in Taiwan .',
  'While lead poisoning among children is on the decline , it is still a serious health problem that affects an estimated 930,000 children between the ages of one and five .',
  'Asymptomatic Pb poisoning of children remains a serious public health problem in the United States .',
  'The results of the determinations indicate that exposure to lead continues to be a serious problem in Polish industry .',
  'We concluded that lead poisoning is still a serious threat to waterfowl in Japan and that there is considerable need for environmental improvement concerning this problem .',
  'Both occupational and environmental exposures to lead remain a serious problem in many developing and industrializing countries , as well as in some developed countries .',
  'The present data concerning Tarragona Province show that in relation to environmental health there is not a serious problem from lead contamination .',
  "Lead ( Pb ) pollution is a serious public health problem all over the world , it especially plays severe damage role in children 's health .",
  'Lead is an environmental toxicant , occupational and environmental exposures remain a serious problem in developing and industrializing countries .',
  'Lead (Pb)-poisoning is a serious public health concern and dogs have been useful as a sentinel-animal for Pb exposure of humans .',
  'Lead toxicity has become a serious public health concern all over the world .',
  'Exposure to lead hazards is a serious health concern for inner-city children .',
  'Lead ( Pb ) contamination in the air is a severe global problem , most notably in China .',
  'Both occupational and environmental exposures to lead remain a serious problem in many developing and industrializing countries and a public health problem of global dimensions .',
  'Prior calculations of the burden of disease from environmental lead exposure in low- \xa0 and middle-income countries ( LMICs ) have not included estimates of the burden from lead-contaminated sites because of a lack of exposure data , resulting in an underestimation of a serious public health problem .',
  'Currently , Pb pollution has become a severe environmental problem and filamentous fungi hold a promising potential for the treatment of Pb-containing wastewater .',
  'As one of the important contaminants in wastewater , Pb(II ) becomes a severe public health problem because of its non-biodegradable and persistent nature .',
  'Childhood lead poisoning is a serious public health concern worldwide .',
  'The presence of lead ( Pb ) in milk and its interaction with trace elements is a serious health concern .',
  'Lead intoxication is a serious occupational disease that constitutes a major public health problem .',
  'Lead (Pb)-based paints pose a serious health problem to people living in residential settings constructed prior to 1978 .',
  'Lead ( Pb ) toxicity has been a serious concern in industrialized societies because of its association with functional deficits in nervous , haematopoietic and renal systems .',
  'Childhood lead poisoning remains a serious public health problem for millions of American children .',
  'Lead ( Pb ) poisoning has always been a serious health concern , as it permanently damages the central nervous system .',
  'Lead contamination is a serious environmental problem with toxic effects in human .',
  'Lead ( Pb ) poisoning in raptors and water birds is a serious problem in many countries .',
  'The contamination of soil by lead ( Pb ) is a serious and widespread problem in China , especially in mining areas .',
  'Asymptomatic lead poisoning remains a serious public health problem in developed and developing countries .',
  'Therefore , Pb poisoning is still a serious problem in raptors in various areas of Japan due to accidental ingestion of materials containing Pb , especially Pb ammunition .',
  'Lead ( Pb ) pollution is a serious problem in the developing countries , especially in South Asia .',
  'Lead poisoning in children is a preventable public health problem that can adversely affect the developing nervous system and result in learning and behavior problems .',
  '[ Lead poisoning in children is a serious problem in the USA ] .'],
 'placental': ["Malaria infection during pregnancy is a serious health problem in most of the world 's tropical regions .",
  'Anaemia is a serious problem in pregnancy in malaria-endemic countries .',
  'Connected with perinatal diseases as well as gastrointestinal and respiratory infections malaria has been still a serious health problem of that region .',
  'Malaria in pregnancy is a serious health problem that contributes greatly to maternal morbidity and mortality .',
  'Malaria during pregnancy remains a serious public health problem , with substantial risks for the mother , her foetus and the newborn .',
  'Malaria in pregnancy remains a serious public health problem in the Republic of Congo despite the implementation of intermittent preventive treatment with sulfadoxine-pyrimethamine ( IPTp-SP ) in 2006 .',
  'Placental malaria is a serious problem in sub-Saharan Africa .',
  'Malaria during pregnancy remains a serious public health problem .',
  'In Colombia , with higher frequency of Plasmodium vivax over Plasmodium falciparum infection , recent reports confirmed gestational malaria as a serious public health problem .',
  'Placental malaria ( PM ) remains a severe public health problem in areas of high malaria transmission .',
  'Malaria during pregnancy remains a serious public health problem .'],
 'fluoroquinolone': ['A serious concern is arising on the coexistence of extended-spectrum beta-lactamase ( ESBL ) and plasmid mediated quinolone resistance ( PMQR ) producing bacteria in animal husbandry , which could be transferred to humans , especially in strains that may not be routinely screened for resistance .',
  'As with all classes of antibiotics , resistance to fluoroquinolones is a serious concern , and multiple avenues for resistance are being investigated .',
  'Due to seriously reduced antibiotic choice for infections caused by ESBL-producing bacteria , ESBLs pose a serious clinical problem .',
  'Fluoroquinolone is widely used for the treatment of bacterial diseases , and the emergence of quinolone resistance has become a serious concern in recent years ,',
  'Fluoroquinolone ( FQ ) resistance of Bacillus anthracis is a serious concern in the fields of biodefense and bioterrorism since FQs are very effective antibiotics and are recommended as first-line treatment against this lethal bacterium .',
  'Widespread horizontal transfer of these genes among bacteria may be a serious public health concern because these can rapidly increase fluoroquinolone resistance .',
  'The resistance of R. anatipestifer to quinolone agents is a serious problem .',
  'This association of ESBL and multiple PMQR mechanisms within the same strains is therefore a serious concern as it hampers the use of both ESCs and fluoroquinolones for severe Salmonella infections .',
  'It was concluded that quinolone-resistance in E. coli remains a serious problem in Hebei , China .',
  'In all , A. baumannii with all the 16S rRNA methylase , modifying enzyme , and ESBL genes is extremely prevalent in northeastern Sichuan , China , posing a serious clinical concern with a major therapeutic threat in the future .',
  'Acquisition of an additional plasmid harbouring ESBL genes is a step towards increasing the risk of O80 EHEC dissemination and represents a serious public health concern .',
  'Bacterial resistance to antibiotics is a serious problem worldwide that affect the increment of morbidity and mortality rate ; Enterobacteriaceae producing ESBL is one of the causes .',
  'Resistance to quinolones is already a serious problem in some countries .',
  'High resistance to quinolones in Salmonella remains a serious problem in Jiangsu , China .',
  'Fluoroquinolone resistant S. Typhi constitute a serious public health concern in endemic areas as well as in industrialized countries .',
  'The appearance of multiple drug resistance along with resistance to quinolones in this bacterium poses a serious therapeutic problem .',
  'Emergence of resistant isolates to both fluoroquinolones and carbapenems during antibiotic therapy is a serious clinical problem .',
  'Drug resistance of the clinical isolates is a serious problem in Guangzhou , and the increasing prevalence of ESBLs-producing strains of other bacteria should be given full attention .',
  'Intra-abdominal infections ( IAIs ) caused by ESBLs producing bacteria have become a serious clinical concern worldwide as the prevalence of bacterial resistance to antibiotics continues to increase .',
  'Resistance to extended-spectrum β-lactams in Salmonella , in particular , in serotypes such as Salmonella enterica serovar Enteritidis that are frequently associated with clinical infections , is a serious public health concern .',
  'Fluoroquinolone resistance is a serious and increasingly common problem in Salmonella .',
  'The increasing number of ESBL-producing or fluoroquinolones-resistant strains remains a serious clinical problem in South Korea .',
  'Therefore , development and increase of quinolone-resistance among clinically isolated pathogens are a worrisome problem .',
  "UTIs due to ESBL-producing E. coli are a serious problem because of the bacteria 's multidrug antibiotic resistance pattern .",
  'The appearance of multiple drug resistance along with resistance to quinolones in this bacterium poses a serious therapeutic problem .',
  'Because ESBL-producing strains are resistant to a wide variety of commonly used antimicrobials , their proliferation poses a serious global health concern that has complicated treatment strategies for a growing number of hospitalized patients .',
  'Despite these favourable properties , the earlier fluoroquinolones had limited potency against some clinically important organisms , especially Gram-positive pathogens so that the development of resistance to these organisms has become a serious problem .',
  'Urinary tract infection caused by ESBL are a serious problem and identifying risk factors facilitates early detection and improved prognosis .',
  'High fluoroquinolone resistance in ETEC may be a serious cause of concern for travelers visiting this region , and thus thereis a need to monitor drug resistance in this pathogen .'],
 'quinolone': ['A serious concern is arising on the coexistence of extended-spectrum beta-lactamase ( ESBL ) and plasmid mediated quinolone resistance ( PMQR ) producing bacteria in animal husbandry , which could be transferred to humans , especially in strains that may not be routinely screened for resistance .',
  'As with all classes of antibiotics , resistance to fluoroquinolones is a serious concern , and multiple avenues for resistance are being investigated .',
  'Due to seriously reduced antibiotic choice for infections caused by ESBL-producing bacteria , ESBLs pose a serious clinical problem .',
  'Fluoroquinolone is widely used for the treatment of bacterial diseases , and the emergence of quinolone resistance has become a serious concern in recent years ,',
  'Fluoroquinolone ( FQ ) resistance of Bacillus anthracis is a serious concern in the fields of biodefense and bioterrorism since FQs are very effective antibiotics and are recommended as first-line treatment against this lethal bacterium .',
  'Widespread horizontal transfer of these genes among bacteria may be a serious public health concern because these can rapidly increase fluoroquinolone resistance .',
  'The resistance of R. anatipestifer to quinolone agents is a serious problem .',
  'This association of ESBL and multiple PMQR mechanisms within the same strains is therefore a serious concern as it hampers the use of both ESCs and fluoroquinolones for severe Salmonella infections .',
  'It was concluded that quinolone-resistance in E. coli remains a serious problem in Hebei , China .',
  'In all , A. baumannii with all the 16S rRNA methylase , modifying enzyme , and ESBL genes is extremely prevalent in northeastern Sichuan , China , posing a serious clinical concern with a major therapeutic threat in the future .',
  'Acquisition of an additional plasmid harbouring ESBL genes is a step towards increasing the risk of O80 EHEC dissemination and represents a serious public health concern .',
  'Bacterial resistance to antibiotics is a serious problem worldwide that affect the increment of morbidity and mortality rate ; Enterobacteriaceae producing ESBL is one of the causes .',
  'Resistance to quinolones is already a serious problem in some countries .',
  'High resistance to quinolones in Salmonella remains a serious problem in Jiangsu , China .',
  'Fluoroquinolone resistant S. Typhi constitute a serious public health concern in endemic areas as well as in industrialized countries .',
  'The appearance of multiple drug resistance along with resistance to quinolones in this bacterium poses a serious therapeutic problem .',
  'Emergence of resistant isolates to both fluoroquinolones and carbapenems during antibiotic therapy is a serious clinical problem .',
  'Drug resistance of the clinical isolates is a serious problem in Guangzhou , and the increasing prevalence of ESBLs-producing strains of other bacteria should be given full attention .',
  'Intra-abdominal infections ( IAIs ) caused by ESBLs producing bacteria have become a serious clinical concern worldwide as the prevalence of bacterial resistance to antibiotics continues to increase .',
  'Resistance to extended-spectrum β-lactams in Salmonella , in particular , in serotypes such as Salmonella enterica serovar Enteritidis that are frequently associated with clinical infections , is a serious public health concern .',
  'Fluoroquinolone resistance is a serious and increasingly common problem in Salmonella .',
  'The increasing number of ESBL-producing or fluoroquinolones-resistant strains remains a serious clinical problem in South Korea .',
  'Therefore , development and increase of quinolone-resistance among clinically isolated pathogens are a worrisome problem .',
  "UTIs due to ESBL-producing E. coli are a serious problem because of the bacteria 's multidrug antibiotic resistance pattern .",
  'The appearance of multiple drug resistance along with resistance to quinolones in this bacterium poses a serious therapeutic problem .',
  'Because ESBL-producing strains are resistant to a wide variety of commonly used antimicrobials , their proliferation poses a serious global health concern that has complicated treatment strategies for a growing number of hospitalized patients .',
  'Despite these favourable properties , the earlier fluoroquinolones had limited potency against some clinically important organisms , especially Gram-positive pathogens so that the development of resistance to these organisms has become a serious problem .',
  'Urinary tract infection caused by ESBL are a serious problem and identifying risk factors facilitates early detection and improved prognosis .',
  'High fluoroquinolone resistance in ETEC may be a serious cause of concern for travelers visiting this region , and thus thereis a need to monitor drug resistance in this pathogen .'],
 'fluoroquinolones': ['A serious concern is arising on the coexistence of extended-spectrum beta-lactamase ( ESBL ) and plasmid mediated quinolone resistance ( PMQR ) producing bacteria in animal husbandry , which could be transferred to humans , especially in strains that may not be routinely screened for resistance .',
  'As with all classes of antibiotics , resistance to fluoroquinolones is a serious concern , and multiple avenues for resistance are being investigated .',
  'Due to seriously reduced antibiotic choice for infections caused by ESBL-producing bacteria , ESBLs pose a serious clinical problem .',
  'Fluoroquinolone is widely used for the treatment of bacterial diseases , and the emergence of quinolone resistance has become a serious concern in recent years ,',
  'Fluoroquinolone ( FQ ) resistance of Bacillus anthracis is a serious concern in the fields of biodefense and bioterrorism since FQs are very effective antibiotics and are recommended as first-line treatment against this lethal bacterium .',
  'Widespread horizontal transfer of these genes among bacteria may be a serious public health concern because these can rapidly increase fluoroquinolone resistance .',
  'The resistance of R. anatipestifer to quinolone agents is a serious problem .',
  'This association of ESBL and multiple PMQR mechanisms within the same strains is therefore a serious concern as it hampers the use of both ESCs and fluoroquinolones for severe Salmonella infections .',
  'It was concluded that quinolone-resistance in E. coli remains a serious problem in Hebei , China .',
  'In all , A. baumannii with all the 16S rRNA methylase , modifying enzyme , and ESBL genes is extremely prevalent in northeastern Sichuan , China , posing a serious clinical concern with a major therapeutic threat in the future .',
  'Acquisition of an additional plasmid harbouring ESBL genes is a step towards increasing the risk of O80 EHEC dissemination and represents a serious public health concern .',
  'Bacterial resistance to antibiotics is a serious problem worldwide that affect the increment of morbidity and mortality rate ; Enterobacteriaceae producing ESBL is one of the causes .',
  'Resistance to quinolones is already a serious problem in some countries .',
  'High resistance to quinolones in Salmonella remains a serious problem in Jiangsu , China .',
  'Fluoroquinolone resistant S. Typhi constitute a serious public health concern in endemic areas as well as in industrialized countries .',
  'The appearance of multiple drug resistance along with resistance to quinolones in this bacterium poses a serious therapeutic problem .',
  'Emergence of resistant isolates to both fluoroquinolones and carbapenems during antibiotic therapy is a serious clinical problem .',
  'Drug resistance of the clinical isolates is a serious problem in Guangzhou , and the increasing prevalence of ESBLs-producing strains of other bacteria should be given full attention .',
  'Intra-abdominal infections ( IAIs ) caused by ESBLs producing bacteria have become a serious clinical concern worldwide as the prevalence of bacterial resistance to antibiotics continues to increase .',
  'Resistance to extended-spectrum β-lactams in Salmonella , in particular , in serotypes such as Salmonella enterica serovar Enteritidis that are frequently associated with clinical infections , is a serious public health concern .',
  'Fluoroquinolone resistance is a serious and increasingly common problem in Salmonella .',
  'The increasing number of ESBL-producing or fluoroquinolones-resistant strains remains a serious clinical problem in South Korea .',
  'Therefore , development and increase of quinolone-resistance among clinically isolated pathogens are a worrisome problem .',
  "UTIs due to ESBL-producing E. coli are a serious problem because of the bacteria 's multidrug antibiotic resistance pattern .",
  'The appearance of multiple drug resistance along with resistance to quinolones in this bacterium poses a serious therapeutic problem .',
  'Because ESBL-producing strains are resistant to a wide variety of commonly used antimicrobials , their proliferation poses a serious global health concern that has complicated treatment strategies for a growing number of hospitalized patients .',
  'Despite these favourable properties , the earlier fluoroquinolones had limited potency against some clinically important organisms , especially Gram-positive pathogens so that the development of resistance to these organisms has become a serious problem .',
  'Urinary tract infection caused by ESBL are a serious problem and identifying risk factors facilitates early detection and improved prognosis .',
  'High fluoroquinolone resistance in ETEC may be a serious cause of concern for travelers visiting this region , and thus thereis a need to monitor drug resistance in this pathogen .'],
 'opisthorchis': ['Opisthorchis viverrini infection is a serious public health problem in Southeast Asia especially in the northeast and north of Thailand .',
  'Opisthorchis viverrini infection is a serious public-health problem in Southeast Asia .',
  'Opisthorchiasis that is widely spreading in Russia and CIS countries was and remains a serious social , medical , and scientific problem .',
  'Opisthorchis viverrini infection is a serious public-health problem in Southeast Asia especially in Lao PDR and Thailand .',
  'Liver fluke infection with Opisthorchis viverrini and its associated cholangiocarcinoma constitute a serious problem in Thailand .',
  'Opisthorchis viverrini infection is an endemic disease that causes a serious public health problem in southeast Asia , especially in northeast Thailand .',
  'Opisthorchiasis is a serious public health problem in East Asia and Europe .',
  "Opisthorchis viverrini is a serious problem in Thailand , Cambodia , the Lao People 's Democratic Republic and Vietnam .",
  'Opisthorchis viverrini-related cholangiocarcinoma ( CCA ) , a fatal bile duct cancer , is a major public health concern in areas endemic for this parasite .',
  'In Thailand , infection with the liver fluke Opisthorchis viverrini is a serious health problem , with over 8.6 million human infections each year .',
  'Thus , clonorchiasis has become a serious public health problem in Guangdong province .',
  'Infection with the human liver fluke , Opisthorchis viverrini , is a serious public health problem in Thailand , Laos and nearby locations in Southeast Asia .',
  'Opisthorchis viverrini infection is a serious public-health problem in Southeast Asia .',
  'Opisthorchiasis caused by O. felineus is a serious public health problem on the territory of Russia and other Eastern European countries .',
  'The liver fluke Opisthorchis viverrini is a serious health problem in Thailand .',
  'Infection with the human liver fluke Opisthorchis felineus is a serious public health problem in Russia and other Eastern Europe countries .',
  'C. sinensis infection is closely related to cholangiocarcinoma ( CCA ) , fibrosis and other human hepatobiliary diseases ; thus , clonorchiasis is a serious public health problem in endemic areas .',
  'Opisthorchis viverrini is still a serious problem in Northeastern and Northern Thailand .',
  'The carcinogenic liver fluke , Opisthorchis viverrini , is a serious health problem in Southeast Asia where infection',
  'Infection with Opisthorchis viverrini appears to be a serious public health problem strongly associated with the frequent eating habit of raw fish in low land Laos .',
  'Opisthorchiasis viverrini is a liver fluke infection causing a serious public health problem in Thailand , Lao PDR , Cambodia , and South Vietnam because it acts as a strong promoter of cholangiocarcinoma .',
  'Despite a long research history going back to 1927 , opisthorchiasis remains a serious problem in Russia , and numerous questions related to the epidemiology of these liver fluke infections and their patterns of distribution in Western Siberia , the causes of high prevalence in different populations , and the prognosis of the epidemiological situation remain to be answered .',
  'The opisthorchiasis caused by Opisthorchis felineus , the Siberian liver fluke remains a serious public health problem in Russia and Eastern Europe .',
  'Opisthorchis viverrini is still a serious problem in rural areas of Thailand particularly Northeastern and Northern region .',
  'Opisthorchiasis caused by Opisthorchis viverrini infection , is a serious public health problem in Lao PDR , Cambodia , Vietnam and Thailand .'],
 'thailand': ['Opisthorchis viverrini infection is a serious public health problem in Southeast Asia especially in the northeast and north of Thailand .',
  'Opisthorchis viverrini infection is a serious public-health problem in Southeast Asia .',
  'Opisthorchiasis that is widely spreading in Russia and CIS countries was and remains a serious social , medical , and scientific problem .',
  'Opisthorchis viverrini infection is a serious public-health problem in Southeast Asia especially in Lao PDR and Thailand .',
  'Liver fluke infection with Opisthorchis viverrini and its associated cholangiocarcinoma constitute a serious problem in Thailand .',
  'Opisthorchis viverrini infection is an endemic disease that causes a serious public health problem in southeast Asia , especially in northeast Thailand .',
  'Opisthorchiasis is a serious public health problem in East Asia and Europe .',
  "Opisthorchis viverrini is a serious problem in Thailand , Cambodia , the Lao People 's Democratic Republic and Vietnam .",
  'Opisthorchis viverrini-related cholangiocarcinoma ( CCA ) , a fatal bile duct cancer , is a major public health concern in areas endemic for this parasite .',
  'In Thailand , infection with the liver fluke Opisthorchis viverrini is a serious health problem , with over 8.6 million human infections each year .',
  'Thus , clonorchiasis has become a serious public health problem in Guangdong province .',
  'Infection with the human liver fluke , Opisthorchis viverrini , is a serious public health problem in Thailand , Laos and nearby locations in Southeast Asia .',
  'Opisthorchis viverrini infection is a serious public-health problem in Southeast Asia .',
  'Opisthorchiasis caused by O. felineus is a serious public health problem on the territory of Russia and other Eastern European countries .',
  'The liver fluke Opisthorchis viverrini is a serious health problem in Thailand .',
  'Infection with the human liver fluke Opisthorchis felineus is a serious public health problem in Russia and other Eastern Europe countries .',
  'C. sinensis infection is closely related to cholangiocarcinoma ( CCA ) , fibrosis and other human hepatobiliary diseases ; thus , clonorchiasis is a serious public health problem in endemic areas .',
  'Opisthorchis viverrini is still a serious problem in Northeastern and Northern Thailand .',
  'The carcinogenic liver fluke , Opisthorchis viverrini , is a serious health problem in Southeast Asia where infection',
  'Infection with Opisthorchis viverrini appears to be a serious public health problem strongly associated with the frequent eating habit of raw fish in low land Laos .',
  'Opisthorchiasis viverrini is a liver fluke infection causing a serious public health problem in Thailand , Lao PDR , Cambodia , and South Vietnam because it acts as a strong promoter of cholangiocarcinoma .',
  'Despite a long research history going back to 1927 , opisthorchiasis remains a serious problem in Russia , and numerous questions related to the epidemiology of these liver fluke infections and their patterns of distribution in Western Siberia , the causes of high prevalence in different populations , and the prognosis of the epidemiological situation remain to be answered .',
  'The opisthorchiasis caused by Opisthorchis felineus , the Siberian liver fluke remains a serious public health problem in Russia and Eastern Europe .',
  'Opisthorchis viverrini is still a serious problem in rural areas of Thailand particularly Northeastern and Northern region .',
  'Opisthorchiasis caused by Opisthorchis viverrini infection , is a serious public health problem in Lao PDR , Cambodia , Vietnam and Thailand .'],
 'opisthorchiasis': ['Opisthorchis viverrini infection is a serious public health problem in Southeast Asia especially in the northeast and north of Thailand .',
  'Opisthorchis viverrini infection is a serious public-health problem in Southeast Asia .',
  'Opisthorchiasis that is widely spreading in Russia and CIS countries was and remains a serious social , medical , and scientific problem .',
  'Opisthorchis viverrini infection is a serious public-health problem in Southeast Asia especially in Lao PDR and Thailand .',
  'Liver fluke infection with Opisthorchis viverrini and its associated cholangiocarcinoma constitute a serious problem in Thailand .',
  'Opisthorchis viverrini infection is an endemic disease that causes a serious public health problem in southeast Asia , especially in northeast Thailand .',
  'Opisthorchiasis is a serious public health problem in East Asia and Europe .',
  "Opisthorchis viverrini is a serious problem in Thailand , Cambodia , the Lao People 's Democratic Republic and Vietnam .",
  'Opisthorchis viverrini-related cholangiocarcinoma ( CCA ) , a fatal bile duct cancer , is a major public health concern in areas endemic for this parasite .',
  'In Thailand , infection with the liver fluke Opisthorchis viverrini is a serious health problem , with over 8.6 million human infections each year .',
  'Thus , clonorchiasis has become a serious public health problem in Guangdong province .',
  'Infection with the human liver fluke , Opisthorchis viverrini , is a serious public health problem in Thailand , Laos and nearby locations in Southeast Asia .',
  'Opisthorchis viverrini infection is a serious public-health problem in Southeast Asia .',
  'Opisthorchiasis caused by O. felineus is a serious public health problem on the territory of Russia and other Eastern European countries .',
  'The liver fluke Opisthorchis viverrini is a serious health problem in Thailand .',
  'Infection with the human liver fluke Opisthorchis felineus is a serious public health problem in Russia and other Eastern Europe countries .',
  'C. sinensis infection is closely related to cholangiocarcinoma ( CCA ) , fibrosis and other human hepatobiliary diseases ; thus , clonorchiasis is a serious public health problem in endemic areas .',
  'Opisthorchis viverrini is still a serious problem in Northeastern and Northern Thailand .',
  'The carcinogenic liver fluke , Opisthorchis viverrini , is a serious health problem in Southeast Asia where infection',
  'Infection with Opisthorchis viverrini appears to be a serious public health problem strongly associated with the frequent eating habit of raw fish in low land Laos .',
  'Opisthorchiasis viverrini is a liver fluke infection causing a serious public health problem in Thailand , Lao PDR , Cambodia , and South Vietnam because it acts as a strong promoter of cholangiocarcinoma .',
  'Despite a long research history going back to 1927 , opisthorchiasis remains a serious problem in Russia , and numerous questions related to the epidemiology of these liver fluke infections and their patterns of distribution in Western Siberia , the causes of high prevalence in different populations , and the prognosis of the epidemiological situation remain to be answered .',
  'The opisthorchiasis caused by Opisthorchis felineus , the Siberian liver fluke remains a serious public health problem in Russia and Eastern Europe .',
  'Opisthorchis viverrini is still a serious problem in rural areas of Thailand particularly Northeastern and Northern region .',
  'Opisthorchiasis caused by Opisthorchis viverrini infection , is a serious public health problem in Lao PDR , Cambodia , Vietnam and Thailand .'],
 'asia': ['Opisthorchis viverrini infection is a serious public health problem in Southeast Asia especially in the northeast and north of Thailand .',
  'Opisthorchis viverrini infection is a serious public-health problem in Southeast Asia .',
  'Opisthorchiasis that is widely spreading in Russia and CIS countries was and remains a serious social , medical , and scientific problem .',
  'Opisthorchis viverrini infection is a serious public-health problem in Southeast Asia especially in Lao PDR and Thailand .',
  'Liver fluke infection with Opisthorchis viverrini and its associated cholangiocarcinoma constitute a serious problem in Thailand .',
  'Opisthorchis viverrini infection is an endemic disease that causes a serious public health problem in southeast Asia , especially in northeast Thailand .',
  'Opisthorchiasis is a serious public health problem in East Asia and Europe .',
  "Opisthorchis viverrini is a serious problem in Thailand , Cambodia , the Lao People 's Democratic Republic and Vietnam .",
  'Opisthorchis viverrini-related cholangiocarcinoma ( CCA ) , a fatal bile duct cancer , is a major public health concern in areas endemic for this parasite .',
  'In Thailand , infection with the liver fluke Opisthorchis viverrini is a serious health problem , with over 8.6 million human infections each year .',
  'Thus , clonorchiasis has become a serious public health problem in Guangdong province .',
  'Infection with the human liver fluke , Opisthorchis viverrini , is a serious public health problem in Thailand , Laos and nearby locations in Southeast Asia .',
  'Opisthorchis viverrini infection is a serious public-health problem in Southeast Asia .',
  'Opisthorchiasis caused by O. felineus is a serious public health problem on the territory of Russia and other Eastern European countries .',
  'The liver fluke Opisthorchis viverrini is a serious health problem in Thailand .',
  'Infection with the human liver fluke Opisthorchis felineus is a serious public health problem in Russia and other Eastern Europe countries .',
  'C. sinensis infection is closely related to cholangiocarcinoma ( CCA ) , fibrosis and other human hepatobiliary diseases ; thus , clonorchiasis is a serious public health problem in endemic areas .',
  'Opisthorchis viverrini is still a serious problem in Northeastern and Northern Thailand .',
  'The carcinogenic liver fluke , Opisthorchis viverrini , is a serious health problem in Southeast Asia where infection',
  'Infection with Opisthorchis viverrini appears to be a serious public health problem strongly associated with the frequent eating habit of raw fish in low land Laos .',
  'Opisthorchiasis viverrini is a liver fluke infection causing a serious public health problem in Thailand , Lao PDR , Cambodia , and South Vietnam because it acts as a strong promoter of cholangiocarcinoma .',
  'Despite a long research history going back to 1927 , opisthorchiasis remains a serious problem in Russia , and numerous questions related to the epidemiology of these liver fluke infections and their patterns of distribution in Western Siberia , the causes of high prevalence in different populations , and the prognosis of the epidemiological situation remain to be answered .',
  'The opisthorchiasis caused by Opisthorchis felineus , the Siberian liver fluke remains a serious public health problem in Russia and Eastern Europe .',
  'Opisthorchis viverrini is still a serious problem in rural areas of Thailand particularly Northeastern and Northern region .',
  'Opisthorchiasis caused by Opisthorchis viverrini infection , is a serious public health problem in Lao PDR , Cambodia , Vietnam and Thailand .'],
 'driving': ['Riding with a drinking driver ( RWDD ) is a serious concern that leads to numerous preventable deaths every year .',
  'Alcohol-impaired driving remains a serious public health concern despite the fact that drinking and driving risks are widely disseminated and well understood by the public .',
  'Falling asleep during driving is a serious problem that has resulted in fatal accidents worldwide .',
  'Among preventable causes of MVCs involving teenage drivers , distracted driving continues to be a serious public health problem .',
  'Underage drinking and driving is a serious behavior problem reported by male and female youth .',
  'Drug and medication use-associated impairment of driving skills is increasingly becoming a serious problem .',
  'AmED use is also related to alcohol-related unsafe driving , which is a serious public health concern .',
  'Drunk driving is a serious social problem .',
  'Drowsy driving is a serious public health concern which is often difficult for individual drivers to identify .',
  'Driving while impaired is a serious national health problem , and there is a need to develop effective treatments for persons arrested for Driving While Intoxicated ( DWI ) .',
  'Drowsy driving is a serious highway safety problem .',
  'However , alcohol-related crashes are a serious problem even for the youngest drivers .',
  'Driving under the influence ( DUI ) continues to be a serious public health concern in the United States .',
  'Driving under the influence ( DUI ) of alcohol and illicit drugs is a serious road safety concern .',
  'Driving after drinking ( DAD ) is a serious public health concern found to be more common among college students than those of other age groups or same-aged non-college peers .',
  'citations are still a serious concern among drivers aged 16 - 20 \xa0 years and have been shown to be related to increased risk of fatal and nonfatal crashes .',
  'Driving under the influence of drugs is a serious road safety problem .',
  'Drinking and driving are still a serious concern on the roads , even though the last twenty years has seen an increase in exposure to various designated driver programs .',
  'The college student population is one of the heaviest drinking demographic groups in the US and impaired driving is a serious alcohol-related problem .',
  'Driving under the influence of drugs is a serious problem for road traffic safety .',
  'Underage driving poses a serious problem in terms of crash outcomes .',
  'Driving under the influence of drugs ( DUID ) is a serious global problem and poses a public health risk .',
  'Unlicensed driving is a serious problem in many Australian states , with unlicensed driving-related crashes ( UDC ) costing up to $ 304 million per year in Queensland , and $ 176 million in Victoria .',
  'Although the number of alcohol-impaired driving ( AID ) fatalities has declined over the past several years , AID continues to be a serious public health problem .',
  'Drunk driving is still a severe traffic safety problem to be addressed in China .',
  'With increasing numbers of countries/jurisdictions legalizing cannabis , cannabis impaired driving has become a serious public health concern .',
  'Drunken driving has become widely recognized as a serious social problem .',
  'Drugged driving is a serious safety concern , but its role in motor vehicle crashes has not been adequately studied .',
  'Driving under the influence of alcohol or other substances is a serious public health concern .',
  'In a study of 124 high-risk drivers , almost 50 % of the drives had a severe problem with alcohol and were driving without a valid license .',
  'Mean blood alcohol level was 1.6 g/l , without any difference according to sex ; it was significantly increased in those checked following a traffic accident , in those having drank spirits , wine and beer and in those having a severe alcohol problem .'],
 'anemia': ['Anemia in children living at all three altitude categories is more than 40 % and a severe public health problem according to the World Health Organization .',
  'Anaemia was a severe public health problem and prevalence differed by residency and eco-region .',
  'Anemia was a severe public health problem in Guatemala , Haiti , and Bolivia .',
  '[ Sickle cell disease : a serious and unknown problem of public health in Brazil ]',
  'Anemia however is a serious public health problem affecting some 30 % of the subjects , with almost half due to ID .',
  'Anemia was found to be a severe public health problem in the study area .',
  'The high prevalence of anaemia indicates it is currently a serious health problem of pregnant women living in Gilgel Gibe Dam area .',
  'Anemic conditions in women and children across the world are a serious cause for concern .',
  'Anemia appears to be a serious public health problem among preschool children in the Sioux Lookout Zone .',
  "Anemia is a severe public health problem in the Lao People 's Democratic Republic ( PDR ) .",
  'Anaemia is a serious health problem in the contemporary world which aff ects 24.8 % of the total human population .',
  'The prevalence of anemia is a severe public health problem among pregnant women of underprivileged ethnic groups in Province 2 .',
  'Anaemia is a severe public health problem among SAC and adolescents in rural Ghana irrespective of sex .',
  'Anaemia was found to be a severe public health problem in Lake Albert , affecting 68·9 % of children ( ninety-five percent confidence intervals ( 95 % CI ) 64·9 - 72·7 % ) , a statistically significant higher prevalence relative to the 27·3 % detected in Lake Victoria ( 95 % CI : 23·3 - 31·7 % ) .',
  'The prevalence of anaemia is a severe nutritional problem of public health significance .',
  'Anaemia is considered a serious public health problem in Egypt , although updated population-based data are lacking .',
  'The prevalence of anemia among adolescent girls is 47.9 % , of which 47.7 % have mild anemia , 51.7 % have moderate anemia , and 5.7 % have severe anemia , which reveals that anemia is a severe public health problem among adolescent girls in the study area .',
  'Anemia is a serious health problem in Indian school children .',
  'To determine eight parameters of oxidative stress markers in erythrocytes from children with sickle cell disease and compare with the same parameters in erythrocytes from healthy children , since oxidative stress plays an important role in the pathophysiology of sickle cell disease and because this disease is a serious public health problem in many countries .',
  'Infantile anaemia has been a severe public health problem in China for decades .',
  'Anemia in children under-5 continues to be a severe public health problem in Ethiopia .',
  'Such findings are consistent with findings of other recent studies in poor , northwest areas of China and led to conclude that anaemia remains a serious health problem among children in parts of China .',
  'Anaemia is considered a severe public health problem by WHO and is seen as such in Ghana .',
  'However , even following this intervention anaemia remained a serious public health problem and additional work to define and evaluate an effective intervention package is warranted .',
  'Anaemia is a serious and common problem among young children in sub-Saharan Africa .',
  'Sickle cell disease is a serious public health problem in Gabon with a relatively high mortality rate .',
  'This study has revealed that the prevalence of anemia in children less than five years is high and a severe public health problem in the study area .',
  'Low coverage in receiving IFA supplement among adolescents is a serious concern for the success of anaemia reduction programme .',
  'Generally , the study showed that anemia was a severe public health problem among infants and young children in the study setting .',
  'Anemia is a severe global public health problem with serious consequences for both the human and socio-economic health .',
  'The prevalence of anemia in Nunavik women is similar to levels observed in non-industrialized countries and represents a severe public health problem that should be further investigated .',
  'However , anaemia in the third trimester is still a severe public health problem among pregnant women in these areas .',
  'Prevalence of anemia among children ( 6 - 23 \xa0 months ) was a severe public health problem in the study area .',
  'Anemia is considered a severe public health problem by World Health Organization when anemia prevalence is equal to or greater than 40 % in the population .',
  'Although it has declined in the past 13 years , anemia in women of childbearing age remains as a serious public health problem .',
  'Microcytic anaemia is getting to be a severe public health concern while malarial anaemia is a mild public health issue in children residing in urban areas of Mount Cameroon .',
  'Anemia is a serious public health concern especially in women of reproductive age ( WRA ) as it causes a high burden of morbidity and mortality and persists through intergenerational cycle .',
  'CONCLUSION : The high prevalence of anemia is regarded as a severe public health problem among preschool children in the city of Cuiabá .',
  'Anaemia is known to have an impact on child development and mortality and is a severe public health problem in most countries in sub-Saharan Africa .',
  'Anemia among hospitalized children in this study was found to be a severe public health problem .',
  'Anemia among Haitian young children and women of childbearing age is a severe public health problem .',
  'These data show that anemia is a serious problem among children from low-income families and suggest that government nutrition programs such as food stamps and WIC are not meeting the needs of these children .',
  "Yet , in many countries a complete management of Cooley 's anaemia is today not feasible for economic or cultural reasons , and this disease remains a serious public health problem .",
  'According to the WHO classification , the overall prevalence of anemia was a severe public health problem .',
  'In conclusion , anemia is a severe public health problem in the Miti-Murhesa health zone , but NIDA is mostly predominant and needs to be further studied .',
  'Anemia prevalence in childhood was found to be a serious public health problem in this municipality .',
  'Childhood anaemia in Ethiopia is a severe public health problem .',
  'Childhood anaemia is considered a severe public health problem in most countries of sub-Saharan Africa .',
  'Anaemia is associated with poor health outcomes and is considered a serious public health problem particularly in low- and middle-income countries .',
  'The results indicate that anemia is a serious public health problem in Jamaica .',
  'Anaemia is a severe public health problem amongst all vulnerable age groups in India .',
  'Anemia has been identified as a severe public health concern among young children in India , however , information on the prevalence of anemia attributed to micronutrient deficiencies is lacking .',
  'In the rural areas in southern Shaanxi Province , anemia in infants aged 6 - 12 months is still a serious public health problem .',
  'Anemia is a serious public health problem in Indian school children .',
  'Anemia is a serious Public Health problem .',
  'Anemia is a serious concern among indigenous populations in North America , and it appears to be widespread among the Inuit despite abundant intakes of heme iron .',
  'Anaemia was found to be a severe public health problem ( defined as > 40 % anaemic ) in five African countries for children aged 7 - 11 years and in four of the same countries for children aged 12 - 14 years .',
  'Anaemia should be considered a serious public-health concern in Cape Verde , mainly for chil- dren below 24 months .',
  'Lay summaryIn India , anemia is a serious public health problem , where 58 % of the children aged 6 - 59 \u2009 months are anemic .',
  'Anemia in kala-azar patients is a serious problem .',
  "However , prevalence of anemia suggests a serious public health problem among women and children , especially in Za'atri camp .",
  'Anemia in children and women is a severe public health problem in Sierra Leone .',
  "The results showed a significant presence of G-6-PD deficiency with predominance of a severe G-6-PD deficiency type in these blood donors in Sana'a City , which could represent an important health problem through occurrence of hemolytic anemia under oxidative stress ."],
 'aflatoxin': ['Aflatoxins represent a serious problem for a food economy based on cereal cultivations used to fodder animal and for human nutrition .',
  'Aflatoxin contamination of crops is a serious problem worldwide .',
  'The gain in the number of aflatoxicoses is a serious hygienic problem .',
  'Aflatoxin contamination in peanut seeds is still a serious problem for the industry and human health .',
  'Aflatoxin contamination of agricultural commodities continues to be a serious problem in the United States .',
  'Aflatoxins are produced by Aspergillus flavus and A. parasiticus in oil-rich seed and grain crops and are a serious problem in agriculture , with aflatoxin B₁ being the most carcinogenic natural compound known .',
  'Aflatoxin contamination of pistachio nuts is a serious problem for many producing countries .',
  'Aflatoxicosis is a serious problem in developing countries with environmental conditions appropriate for the biosynthesis of AFB1 byAspergillus flavus andAspergillus parasiticus .',
  'Aflatoxin contamination of food and grain poses a serious economic and health problem worldwide , but particularly in Africa .',
  'Aflatoxin contamination of grains and agro-products is a serious food safety issue and a significant economic concern worldwide .',
  'Contamination of milk and milk products with aflatoxin M1 does not appear to be a serious public health problem in the city of Campinas at the moment .',
  'Aflatoxin contamination of food and grain poses a serious economic and health problem globally .',
  'Aflatoxin contamination of agricultural commodities both pre- and postharvest is a serious food safety issue and a significant economic concern .',
  'Food and feedstuff contamination with aflatoxins ( AFTs ) is a serious health problem for humans and animals , especially in developing countries .',
  'Aflatoxin contamination of food and feed stuff is a serious health problem and significant economic concerns .',
  'Aflatoxin ( highly toxic and carcinogenic secondary metabolites produced by fungi ) contamination is a serious problem worldwide .',
  'The worldwide human exposure to aflatoxin B1 ( AFB1 ) , particularly in developing countries , remains to be a serious public health concern .',
  'Preharvest of corn and its contamination with aflatoxin is a serious problem .',
  'The potential presence of aflatoxins in maize destined for human consumption is a serious problem to the Mexican food supply , as these toxic compounds may persist during the traditional alkaline-process for tortilla elaboration .',
  'In California , aflatoxin contamination of almond , fig , and pistachio has become a serious problem in recent years due to long periods of drought and probably other climatic changes .'],
 'aflatoxins': ['Aflatoxins represent a serious problem for a food economy based on cereal cultivations used to fodder animal and for human nutrition .',
  'Aflatoxin contamination of crops is a serious problem worldwide .',
  'The gain in the number of aflatoxicoses is a serious hygienic problem .',
  'Aflatoxin contamination in peanut seeds is still a serious problem for the industry and human health .',
  'Aflatoxin contamination of agricultural commodities continues to be a serious problem in the United States .',
  'Aflatoxins are produced by Aspergillus flavus and A. parasiticus in oil-rich seed and grain crops and are a serious problem in agriculture , with aflatoxin B₁ being the most carcinogenic natural compound known .',
  'Aflatoxin contamination of pistachio nuts is a serious problem for many producing countries .',
  'Aflatoxicosis is a serious problem in developing countries with environmental conditions appropriate for the biosynthesis of AFB1 byAspergillus flavus andAspergillus parasiticus .',
  'Aflatoxin contamination of food and grain poses a serious economic and health problem worldwide , but particularly in Africa .',
  'Aflatoxin contamination of grains and agro-products is a serious food safety issue and a significant economic concern worldwide .',
  'Contamination of milk and milk products with aflatoxin M1 does not appear to be a serious public health problem in the city of Campinas at the moment .',
  'Aflatoxin contamination of food and grain poses a serious economic and health problem globally .',
  'Aflatoxin contamination of agricultural commodities both pre- and postharvest is a serious food safety issue and a significant economic concern .',
  'Food and feedstuff contamination with aflatoxins ( AFTs ) is a serious health problem for humans and animals , especially in developing countries .',
  'Aflatoxin contamination of food and feed stuff is a serious health problem and significant economic concerns .',
  'Aflatoxin ( highly toxic and carcinogenic secondary metabolites produced by fungi ) contamination is a serious problem worldwide .',
  'The worldwide human exposure to aflatoxin B1 ( AFB1 ) , particularly in developing countries , remains to be a serious public health concern .',
  'Preharvest of corn and its contamination with aflatoxin is a serious problem .',
  'The potential presence of aflatoxins in maize destined for human consumption is a serious problem to the Mexican food supply , as these toxic compounds may persist during the traditional alkaline-process for tortilla elaboration .',
  'In California , aflatoxin contamination of almond , fig , and pistachio has become a serious problem in recent years due to long periods of drought and probably other climatic changes .'],
 'contamination': ['Aflatoxins represent a serious problem for a food economy based on cereal cultivations used to fodder animal and for human nutrition .',
  'Aflatoxin contamination of crops is a serious problem worldwide .',
  'The gain in the number of aflatoxicoses is a serious hygienic problem .',
  'Aflatoxin contamination in peanut seeds is still a serious problem for the industry and human health .',
  'Aflatoxin contamination of agricultural commodities continues to be a serious problem in the United States .',
  'Aflatoxins are produced by Aspergillus flavus and A. parasiticus in oil-rich seed and grain crops and are a serious problem in agriculture , with aflatoxin B₁ being the most carcinogenic natural compound known .',
  'Aflatoxin contamination of pistachio nuts is a serious problem for many producing countries .',
  'Aflatoxicosis is a serious problem in developing countries with environmental conditions appropriate for the biosynthesis of AFB1 byAspergillus flavus andAspergillus parasiticus .',
  'Aflatoxin contamination of food and grain poses a serious economic and health problem worldwide , but particularly in Africa .',
  'Aflatoxin contamination of grains and agro-products is a serious food safety issue and a significant economic concern worldwide .',
  'Contamination of milk and milk products with aflatoxin M1 does not appear to be a serious public health problem in the city of Campinas at the moment .',
  'Aflatoxin contamination of food and grain poses a serious economic and health problem globally .',
  'Aflatoxin contamination of agricultural commodities both pre- and postharvest is a serious food safety issue and a significant economic concern .',
  'Food and feedstuff contamination with aflatoxins ( AFTs ) is a serious health problem for humans and animals , especially in developing countries .',
  'Aflatoxin contamination of food and feed stuff is a serious health problem and significant economic concerns .',
  'Aflatoxin ( highly toxic and carcinogenic secondary metabolites produced by fungi ) contamination is a serious problem worldwide .',
  'The worldwide human exposure to aflatoxin B1 ( AFB1 ) , particularly in developing countries , remains to be a serious public health concern .',
  'Preharvest of corn and its contamination with aflatoxin is a serious problem .',
  'The potential presence of aflatoxins in maize destined for human consumption is a serious problem to the Mexican food supply , as these toxic compounds may persist during the traditional alkaline-process for tortilla elaboration .',
  'In California , aflatoxin contamination of almond , fig , and pistachio has become a serious problem in recent years due to long periods of drought and probably other climatic changes .'],
 'methamphetamine': ['Methamphetamine is a serious illicit drug problem in the United States and globally .',
  "Methamphetamine remains a serious public health concern for the United States and especially in the state of Hawai'i .",
  'Methamphetamine addiction is a serious public health problem in those countries .',
  'Methamphetamine dependence presents a serious problem not only for patients but also for society .',
  'The manufacturing of methamphetamine is a serious problem for the child welfare system , yet child welfare has not addressed the needs of children living in homes where methamphetamine is manufactured ( U.S. Department of Justice , 2002 ; DOJ , 2003 ; Altshuler , 2005 ) .',
  'The recreational use of methamphetamine and dextromethorphan in teenagers and young adults in Thailand is a serious problem .',
  'Methamphetamine abuse is a serious global health problem , and no effective treatments for methamphetamine dependence have been developed .',
  'Methamphetamine misuse is a serious health problem of epidemic proportions .',
  'Phenylalkylamine derivatives , such as methamphetamine ( MA ) , 3,4-methylenedioxymethamphetamine ( MDMA ) , phentermine , fenfluramine , phendimetrazine , amfepramone , and ketamine , are widely abused recreational or anorectic drugs in Korea , and their abuse has become a serious social problem .',
  'Methamphetamine ( MA ) addiction is a serious public health problem , and current methods to abate addiction and relapse are currently ineffective for mitigating this growing global epidemic .',
  'Methamphetamine ( METH ) abuse is a serious social and health problem worldwide .',
  'Methamphetamine ( METH ) abuse is a serious health and social problem worldwide .',
  'Methamphetamine ( METH ) use and dependence is a serious public health concern with implications across multiple areas from societal impact to burden on psychiatric and medical resources .',
  'Methamphetamine use has become a serious problem in Cape Town , particularly among adolescents .',
  'Methamphetamine ( METH ) dependence is becoming a serious socioeconomic health problem worldwide .',
  'Methamphetamine ( METH ) use has increased substantially in the last 10 years and poses a serious health concern , especially for young populations .',
  'Although methamphetamine use is a serious public health problem , large-scale cohort studies assessing methamphetamine-related mortality are scant .',
  'Methamphetamine ( METH ) , a substance with a high potential for abuse and addiction , is a serious worldwide public health problem .',
  'Methamphetamine dependence is a serious health problem among Iranian methadone patients .',
  'Methamphetamine dependence is a serious worldwide public health problem with major medical , psychiatric , socioeconomic and legal consequences .',
  'd-Methamphetamine ( METH ) addiction is a serious public health concern for which successful treatment remains elusive .',
  'Although methamphetamine use is a serious public health concern , only a few studies have examined HIV testing among young drug users .',
  'At present , the harm of new-type drug , methamphetamine ( METH ) , has gradually exceeded that of the traditional opioid drugs , and METH abuse has become a serious public health and social problem .',
  'Methamphetamine use is a serious public health concern in many countries and is second to cannabis as the most widely abused illicit drug in the world .',
  'The interactive effects of HIV-1 infection and methamphetamine ( METH ) abuse in producing cognitive dysfunction represent a serious medical problem ; however , the neural mechanisms underlying this interactive neurotoxicity remain elusive .',
  'Methamphetamine addiction is a serious worldwide public health problem with many consequences and complications .',
  'Methamphetamine abuse and dependence , frequently accompanied by schizophrenia-like psychotic symptoms [ methamphetamine-associated psychosis ( MAP ) ] , is a serious public health problem worldwide .',
  'The production and use of the highly addictive stimulant methamphetamine are a serious public health problem in the United States and globally .',
  'Methamphetamine use has become a serious global public health problem and puts increasing burdens on healthcare services .',
  "While the oral use of methaqualone ( Quaalude , Mandrax ) has waned in western countries since the mid-late 1980 's , the practice of smoking methaqualone is a serious public health problem in South Africa , other parts of Africa and India .",
  'Methamphetamine ( METH ) abuse has been a serious global public health problem for decades .',
  'Methamphetamine ( MA ) is a sympathomimetic amine whose abuse has become a serious problem in Japan , Korea , Taiwan and other Southeast Asian countries .',
  'Methamphetamine ( MA ) abuse is a serious and costly public health problem worldwide ; It also commonly affects the sleep quality .',
  'Methamphetamine ( METH ) dependence , especially among women , is a serious global health problem .',
  'Methamphetamine abuse has become a serious public health problem .',
  'Methamphetamine ( MAMP ) use , distribution , and manufacture remain a serious public health and safety problem in the United States , and children environmentally exposed to MAMP face a myriad of developmental , social , and health risks , including severe abuse and neglect necessitating child protection involvement .',
  'Drug addiction continues to threaten the health and welfare of people worldwide , and ephedrine abuse is a serious drug problem in many areas of the world .'],
 'meth': ['Methamphetamine is a serious illicit drug problem in the United States and globally .',
  "Methamphetamine remains a serious public health concern for the United States and especially in the state of Hawai'i .",
  'Methamphetamine addiction is a serious public health problem in those countries .',
  'Methamphetamine dependence presents a serious problem not only for patients but also for society .',
  'The manufacturing of methamphetamine is a serious problem for the child welfare system , yet child welfare has not addressed the needs of children living in homes where methamphetamine is manufactured ( U.S. Department of Justice , 2002 ; DOJ , 2003 ; Altshuler , 2005 ) .',
  'The recreational use of methamphetamine and dextromethorphan in teenagers and young adults in Thailand is a serious problem .',
  'Methamphetamine abuse is a serious global health problem , and no effective treatments for methamphetamine dependence have been developed .',
  'Methamphetamine misuse is a serious health problem of epidemic proportions .',
  'Phenylalkylamine derivatives , such as methamphetamine ( MA ) , 3,4-methylenedioxymethamphetamine ( MDMA ) , phentermine , fenfluramine , phendimetrazine , amfepramone , and ketamine , are widely abused recreational or anorectic drugs in Korea , and their abuse has become a serious social problem .',
  'Methamphetamine ( MA ) addiction is a serious public health problem , and current methods to abate addiction and relapse are currently ineffective for mitigating this growing global epidemic .',
  'Methamphetamine ( METH ) abuse is a serious social and health problem worldwide .',
  'Methamphetamine ( METH ) abuse is a serious health and social problem worldwide .',
  'Methamphetamine ( METH ) use and dependence is a serious public health concern with implications across multiple areas from societal impact to burden on psychiatric and medical resources .',
  'Methamphetamine use has become a serious problem in Cape Town , particularly among adolescents .',
  'Methamphetamine ( METH ) dependence is becoming a serious socioeconomic health problem worldwide .',
  'Methamphetamine ( METH ) use has increased substantially in the last 10 years and poses a serious health concern , especially for young populations .',
  'Although methamphetamine use is a serious public health problem , large-scale cohort studies assessing methamphetamine-related mortality are scant .',
  'Methamphetamine ( METH ) , a substance with a high potential for abuse and addiction , is a serious worldwide public health problem .',
  'Methamphetamine dependence is a serious health problem among Iranian methadone patients .',
  'Methamphetamine dependence is a serious worldwide public health problem with major medical , psychiatric , socioeconomic and legal consequences .',
  'd-Methamphetamine ( METH ) addiction is a serious public health concern for which successful treatment remains elusive .',
  'Although methamphetamine use is a serious public health concern , only a few studies have examined HIV testing among young drug users .',
  'At present , the harm of new-type drug , methamphetamine ( METH ) , has gradually exceeded that of the traditional opioid drugs , and METH abuse has become a serious public health and social problem .',
  'Methamphetamine use is a serious public health concern in many countries and is second to cannabis as the most widely abused illicit drug in the world .',
  'The interactive effects of HIV-1 infection and methamphetamine ( METH ) abuse in producing cognitive dysfunction represent a serious medical problem ; however , the neural mechanisms underlying this interactive neurotoxicity remain elusive .',
  'Methamphetamine addiction is a serious worldwide public health problem with many consequences and complications .',
  'Methamphetamine abuse and dependence , frequently accompanied by schizophrenia-like psychotic symptoms [ methamphetamine-associated psychosis ( MAP ) ] , is a serious public health problem worldwide .',
  'The production and use of the highly addictive stimulant methamphetamine are a serious public health problem in the United States and globally .',
  'Methamphetamine use has become a serious global public health problem and puts increasing burdens on healthcare services .',
  "While the oral use of methaqualone ( Quaalude , Mandrax ) has waned in western countries since the mid-late 1980 's , the practice of smoking methaqualone is a serious public health problem in South Africa , other parts of Africa and India .",
  'Methamphetamine ( METH ) abuse has been a serious global public health problem for decades .',
  'Methamphetamine ( MA ) is a sympathomimetic amine whose abuse has become a serious problem in Japan , Korea , Taiwan and other Southeast Asian countries .',
  'Methamphetamine ( MA ) abuse is a serious and costly public health problem worldwide ; It also commonly affects the sleep quality .',
  'Methamphetamine ( METH ) dependence , especially among women , is a serious global health problem .',
  'Methamphetamine abuse has become a serious public health problem .',
  'Methamphetamine ( MAMP ) use , distribution , and manufacture remain a serious public health and safety problem in the United States , and children environmentally exposed to MAMP face a myriad of developmental , social , and health risks , including severe abuse and neglect necessitating child protection involvement .',
  'Drug addiction continues to threaten the health and welfare of people worldwide , and ephedrine abuse is a serious drug problem in many areas of the world .'],
 'loneliness': ['WHAT IS KNOWN ABOUT THE SUBJECT ? : Loneliness among people diagnosed with schizophrenia is a serious problem .',
  'Social isolation is a serious problem in our society , and the chronically ill are especially vulnerable .',
  'Elder polyvictimization is a serious problem affecting community-residing older adults with identifiable targets for intervention .',
  'Although loneliness is often viewed as a serious problem of old age , few studies have addressed either its measurement or prevalence among older populations .',
  'Loneliness in later life remains a serious problem despite extensive research across the life span .',
  'Loneliness was deemed to be a serious problem for 69 % of respondents , and 79 % reported feeling lonely at least once per month .',
  'Loneliness is a pervasive problem recognised as a serious social issue , and the prevailing COVID-19 pandemic has exacerbated loneliness to greater prominence and concern .',
  'We examined the effect of social engagement ( SE ) on mortality in 30,070 long-stay nursing home residents who were > or = 65 years of age and did not have a serious communication problem .',
  'Loneliness is a serious public health problem associated with increased morbidity and mortality .',
  'Prior to COVID-19 , social isolation and loneliness among older adults was considered a serious public health concern .',
  'Loneliness is a serious concern in aging populations .',
  'Loneliness is a serious problem for older people , which can be alleviated by social support .'],
 'isolation': ['WHAT IS KNOWN ABOUT THE SUBJECT ? : Loneliness among people diagnosed with schizophrenia is a serious problem .',
  'Social isolation is a serious problem in our society , and the chronically ill are especially vulnerable .',
  'Elder polyvictimization is a serious problem affecting community-residing older adults with identifiable targets for intervention .',
  'Although loneliness is often viewed as a serious problem of old age , few studies have addressed either its measurement or prevalence among older populations .',
  'Loneliness in later life remains a serious problem despite extensive research across the life span .',
  'Loneliness was deemed to be a serious problem for 69 % of respondents , and 79 % reported feeling lonely at least once per month .',
  'Loneliness is a pervasive problem recognised as a serious social issue , and the prevailing COVID-19 pandemic has exacerbated loneliness to greater prominence and concern .',
  'We examined the effect of social engagement ( SE ) on mortality in 30,070 long-stay nursing home residents who were > or = 65 years of age and did not have a serious communication problem .',
  'Loneliness is a serious public health problem associated with increased morbidity and mortality .',
  'Prior to COVID-19 , social isolation and loneliness among older adults was considered a serious public health concern .',
  'Loneliness is a serious concern in aging populations .',
  'Loneliness is a serious problem for older people , which can be alleviated by social support .'],
 'fruits': ['Postharvest browning of Agaricus mushrooms is a severe problem that reduces the shelf life of harvested mushrooms because of their continued respiration and biochemical activity .',
  'Enzymatic browning of sprouts during storage is a serious problem negatively influencing their consumer quality .',
  'Practical Application : Pericarp browning is a serious problem to storage and transport of harvested rambutan fruit .',
  'Flavor deterioration is a serious problem in dried carrots during storage and is frequently accompanied by water absorption and bacterial growth .',
  'The internal blue discoloration of edible daikon roots often occurs on day 3 after harvest during storage at 20 ° C and is a serious problem .',
  'This temperature rise may present a serious biological problem , since it can cause iatrogenic thermal trauma to the pulp .',
  'Browning reactions in fruits and vegetables are a serious problem for the food industry .',
  'Browning reactions in fruits and vegetables are a serious problem for the food industry .',
  'The internal blue discoloration observed in Japanese radish ( Raphanus sativus L. ) roots is a physiological phenomenon caused by storage following harvest at approximately 20 ° C and poses a serious problem for farmers .',
  'Browning reactions in fruits and vegetables are recognized as a serious problem for the European food industry , particularly for the mushroom sector .',
  'Superficial scald during post-harvest storage is a serious problem for long-term preservation and shelf-life of some apple and pear cultivars .'],
 'vegetables': ['Postharvest browning of Agaricus mushrooms is a severe problem that reduces the shelf life of harvested mushrooms because of their continued respiration and biochemical activity .',
  'Enzymatic browning of sprouts during storage is a serious problem negatively influencing their consumer quality .',
  'Practical Application : Pericarp browning is a serious problem to storage and transport of harvested rambutan fruit .',
  'Flavor deterioration is a serious problem in dried carrots during storage and is frequently accompanied by water absorption and bacterial growth .',
  'The internal blue discoloration of edible daikon roots often occurs on day 3 after harvest during storage at 20 ° C and is a serious problem .',
  'This temperature rise may present a serious biological problem , since it can cause iatrogenic thermal trauma to the pulp .',
  'Browning reactions in fruits and vegetables are a serious problem for the food industry .',
  'Browning reactions in fruits and vegetables are a serious problem for the food industry .',
  'The internal blue discoloration observed in Japanese radish ( Raphanus sativus L. ) roots is a physiological phenomenon caused by storage following harvest at approximately 20 ° C and poses a serious problem for farmers .',
  'Browning reactions in fruits and vegetables are recognized as a serious problem for the European food industry , particularly for the mushroom sector .',
  'Superficial scald during post-harvest storage is a serious problem for long-term preservation and shelf-life of some apple and pear cultivars .'],
 'harvest': ['Postharvest browning of Agaricus mushrooms is a severe problem that reduces the shelf life of harvested mushrooms because of their continued respiration and biochemical activity .',
  'Enzymatic browning of sprouts during storage is a serious problem negatively influencing their consumer quality .',
  'Practical Application : Pericarp browning is a serious problem to storage and transport of harvested rambutan fruit .',
  'Flavor deterioration is a serious problem in dried carrots during storage and is frequently accompanied by water absorption and bacterial growth .',
  'The internal blue discoloration of edible daikon roots often occurs on day 3 after harvest during storage at 20 ° C and is a serious problem .',
  'This temperature rise may present a serious biological problem , since it can cause iatrogenic thermal trauma to the pulp .',
  'Browning reactions in fruits and vegetables are a serious problem for the food industry .',
  'Browning reactions in fruits and vegetables are a serious problem for the food industry .',
  'The internal blue discoloration observed in Japanese radish ( Raphanus sativus L. ) roots is a physiological phenomenon caused by storage following harvest at approximately 20 ° C and poses a serious problem for farmers .',
  'Browning reactions in fruits and vegetables are recognized as a serious problem for the European food industry , particularly for the mushroom sector .',
  'Superficial scald during post-harvest storage is a serious problem for long-term preservation and shelf-life of some apple and pear cultivars .'],
 'harvested': ['Postharvest browning of Agaricus mushrooms is a severe problem that reduces the shelf life of harvested mushrooms because of their continued respiration and biochemical activity .',
  'Enzymatic browning of sprouts during storage is a serious problem negatively influencing their consumer quality .',
  'Practical Application : Pericarp browning is a serious problem to storage and transport of harvested rambutan fruit .',
  'Flavor deterioration is a serious problem in dried carrots during storage and is frequently accompanied by water absorption and bacterial growth .',
  'The internal blue discoloration of edible daikon roots often occurs on day 3 after harvest during storage at 20 ° C and is a serious problem .',
  'This temperature rise may present a serious biological problem , since it can cause iatrogenic thermal trauma to the pulp .',
  'Browning reactions in fruits and vegetables are a serious problem for the food industry .',
  'Browning reactions in fruits and vegetables are a serious problem for the food industry .',
  'The internal blue discoloration observed in Japanese radish ( Raphanus sativus L. ) roots is a physiological phenomenon caused by storage following harvest at approximately 20 ° C and poses a serious problem for farmers .',
  'Browning reactions in fruits and vegetables are recognized as a serious problem for the European food industry , particularly for the mushroom sector .',
  'Superficial scald during post-harvest storage is a serious problem for long-term preservation and shelf-life of some apple and pear cultivars .'],
 'mushrooms': ['Postharvest browning of Agaricus mushrooms is a severe problem that reduces the shelf life of harvested mushrooms because of their continued respiration and biochemical activity .',
  'Enzymatic browning of sprouts during storage is a serious problem negatively influencing their consumer quality .',
  'Practical Application : Pericarp browning is a serious problem to storage and transport of harvested rambutan fruit .',
  'Flavor deterioration is a serious problem in dried carrots during storage and is frequently accompanied by water absorption and bacterial growth .',
  'The internal blue discoloration of edible daikon roots often occurs on day 3 after harvest during storage at 20 ° C and is a serious problem .',
  'This temperature rise may present a serious biological problem , since it can cause iatrogenic thermal trauma to the pulp .',
  'Browning reactions in fruits and vegetables are a serious problem for the food industry .',
  'Browning reactions in fruits and vegetables are a serious problem for the food industry .',
  'The internal blue discoloration observed in Japanese radish ( Raphanus sativus L. ) roots is a physiological phenomenon caused by storage following harvest at approximately 20 ° C and poses a serious problem for farmers .',
  'Browning reactions in fruits and vegetables are recognized as a serious problem for the European food industry , particularly for the mushroom sector .',
  'Superficial scald during post-harvest storage is a serious problem for long-term preservation and shelf-life of some apple and pear cultivars .'],
 'constipation': ['Constipation is not a life-threatening problem ; however , affected patients may suffer a great deal of angst and have their lives disrupted , especially when it is left untreated .',
  'Constipation is considered a preventable problem in health care , yet this condition has received little attention in terms of preventive interventions and management in people with intellectual disabilities .',
  'Constipation can be a distressing problem for the child and the family .',
  'Constipation is a distressing condition that can happen to anyone , but is of particular concern in the elderly and less mobile , people with neurological impairments , and those in institutional care .',
  'In clinical practice constipation is often an overlooked aspect of patient care and first gains attention when it has become a severe problem for the patients .',
  'Constipation may be the sign of a serious problem such as a mass lesion , the manifestation of a systemic disorder such as hypothyroidism or a side effect of medications such as narcotic analgesics .',
  "Constipation can be a serious and painful problem , and we should n't dismiss other people 's suffering .",
  'Constipation is a serious problem for persons with mental and physical disabilities in Japan .',
  "It is not a life-threatening disease , but since patient 's satisfaction to the treatment is known to be as low as 50 % , chronic constipation still remains a clinically challenging problem .",
  'Constipation is often a preventable problem in health care ; therefore health professionals must have the appropriate knowledge to help patients prevent this common complaint occurring .',
  'Chronic constipation , in addition to diarrhoea , gall bladder dysfunction and incontinence , is increasingly regarded as a serious problem and for the first time , is now considered in the current guidelines of the professional societies .',
  'Chronic idiopathic constipation , especially the slow transit type , is a troubling problem often afflicting young women .'],
 'anabolic': ['Abuse of cocaine and androgenic-anabolic steroids ( AASs ) has become a serious public health problem .',
  'Illicit use of anabolic androgenic steroids ( AAS ) has grown into a serious public health concern throughout the Western World .',
  'Doping in sports has become a serious problem .',
  'Since the 1980s the use of AS has become prevalent among adults and adolescents who are concerned with muscle size and strength , and the abuse of these agents is regarded as a serious drug problem .',
  'Anabolic ergogenic substance use , in particular the use of anabolic androgenic steroids , is a serious problem in general .',
  'Sport and doping are a contradiction in terms , however , doping abuse in sports has been a serious problem for many years .',
  'Abuse of cocaine and androgenic-anabolic steroids has become a serious public health problem .',
  'Apart from the nearly daily announcements on doping in sport there are ever increasing numbers of professionally employed people in vastly different functions and professions who make use of performance-enhancing substances : a serious social problem . It is not astonishing that even physicians and trauma surgeons who are under constant pressure from costs , time and performance demands also consume performance-enhancing drugs .',
  'Anabolic-androgenic steroid ( AAS ) use has been identified as a serious public health problem .',
  'Intentional misrepresentation , where athletes " cheat " on classification tests , remains a serious concern .',
  'For 86.5 % of the questioned physicians , doping is a serious public health problem and 60 % of them consider it as a kind of drug addiction .',
  'The supply of human growth hormone now available to athletes seems small and costly , but drug testing experts agree that abuse of the substance could become a serious problem , especially if synthetic hormone becomes more widely available .',
  'Hematological manipulation to optimize aerobic performances is a serious problem in elite and professional sports and the approach to identify blood doping is as yet challenging .'],
 'doping': ['Abuse of cocaine and androgenic-anabolic steroids ( AASs ) has become a serious public health problem .',
  'Illicit use of anabolic androgenic steroids ( AAS ) has grown into a serious public health concern throughout the Western World .',
  'Doping in sports has become a serious problem .',
  'Since the 1980s the use of AS has become prevalent among adults and adolescents who are concerned with muscle size and strength , and the abuse of these agents is regarded as a serious drug problem .',
  'Anabolic ergogenic substance use , in particular the use of anabolic androgenic steroids , is a serious problem in general .',
  'Sport and doping are a contradiction in terms , however , doping abuse in sports has been a serious problem for many years .',
  'Abuse of cocaine and androgenic-anabolic steroids has become a serious public health problem .',
  'Apart from the nearly daily announcements on doping in sport there are ever increasing numbers of professionally employed people in vastly different functions and professions who make use of performance-enhancing substances : a serious social problem . It is not astonishing that even physicians and trauma surgeons who are under constant pressure from costs , time and performance demands also consume performance-enhancing drugs .',
  'Anabolic-androgenic steroid ( AAS ) use has been identified as a serious public health problem .',
  'Intentional misrepresentation , where athletes " cheat " on classification tests , remains a serious concern .',
  'For 86.5 % of the questioned physicians , doping is a serious public health problem and 60 % of them consider it as a kind of drug addiction .',
  'The supply of human growth hormone now available to athletes seems small and costly , but drug testing experts agree that abuse of the substance could become a serious problem , especially if synthetic hormone becomes more widely available .',
  'Hematological manipulation to optimize aerobic performances is a serious problem in elite and professional sports and the approach to identify blood doping is as yet challenging .'],
 'androgenic': ['Abuse of cocaine and androgenic-anabolic steroids ( AASs ) has become a serious public health problem .',
  'Illicit use of anabolic androgenic steroids ( AAS ) has grown into a serious public health concern throughout the Western World .',
  'Doping in sports has become a serious problem .',
  'Since the 1980s the use of AS has become prevalent among adults and adolescents who are concerned with muscle size and strength , and the abuse of these agents is regarded as a serious drug problem .',
  'Anabolic ergogenic substance use , in particular the use of anabolic androgenic steroids , is a serious problem in general .',
  'Sport and doping are a contradiction in terms , however , doping abuse in sports has been a serious problem for many years .',
  'Abuse of cocaine and androgenic-anabolic steroids has become a serious public health problem .',
  'Apart from the nearly daily announcements on doping in sport there are ever increasing numbers of professionally employed people in vastly different functions and professions who make use of performance-enhancing substances : a serious social problem . It is not astonishing that even physicians and trauma surgeons who are under constant pressure from costs , time and performance demands also consume performance-enhancing drugs .',
  'Anabolic-androgenic steroid ( AAS ) use has been identified as a serious public health problem .',
  'Intentional misrepresentation , where athletes " cheat " on classification tests , remains a serious concern .',
  'For 86.5 % of the questioned physicians , doping is a serious public health problem and 60 % of them consider it as a kind of drug addiction .',
  'The supply of human growth hormone now available to athletes seems small and costly , but drug testing experts agree that abuse of the substance could become a serious problem , especially if synthetic hormone becomes more widely available .',
  'Hematological manipulation to optimize aerobic performances is a serious problem in elite and professional sports and the approach to identify blood doping is as yet challenging .'],
 'steroids': ['Abuse of cocaine and androgenic-anabolic steroids ( AASs ) has become a serious public health problem .',
  'Illicit use of anabolic androgenic steroids ( AAS ) has grown into a serious public health concern throughout the Western World .',
  'Doping in sports has become a serious problem .',
  'Since the 1980s the use of AS has become prevalent among adults and adolescents who are concerned with muscle size and strength , and the abuse of these agents is regarded as a serious drug problem .',
  'Anabolic ergogenic substance use , in particular the use of anabolic androgenic steroids , is a serious problem in general .',
  'Sport and doping are a contradiction in terms , however , doping abuse in sports has been a serious problem for many years .',
  'Abuse of cocaine and androgenic-anabolic steroids has become a serious public health problem .',
  'Apart from the nearly daily announcements on doping in sport there are ever increasing numbers of professionally employed people in vastly different functions and professions who make use of performance-enhancing substances : a serious social problem . It is not astonishing that even physicians and trauma surgeons who are under constant pressure from costs , time and performance demands also consume performance-enhancing drugs .',
  'Anabolic-androgenic steroid ( AAS ) use has been identified as a serious public health problem .',
  'Intentional misrepresentation , where athletes " cheat " on classification tests , remains a serious concern .',
  'For 86.5 % of the questioned physicians , doping is a serious public health problem and 60 % of them consider it as a kind of drug addiction .',
  'The supply of human growth hormone now available to athletes seems small and costly , but drug testing experts agree that abuse of the substance could become a serious problem , especially if synthetic hormone becomes more widely available .',
  'Hematological manipulation to optimize aerobic performances is a serious problem in elite and professional sports and the approach to identify blood doping is as yet challenging .'],
 'sports': ['Abuse of cocaine and androgenic-anabolic steroids ( AASs ) has become a serious public health problem .',
  'Concussion is currently a serious health problem and can lead to severe brain dysfunction .',
  'Head injury remains a serious public problem , especially in the young population .',
  'Underreporting of concussions is proposed as a serious concern , and concussion understanding and attitudes can impact reporting .',
  'Despite concussion being a serious public health concern and the increasing participation of female athletes in sport , the comparative long-term outcomes of male and female athletes are poorly understood , potentially limiting the scientific understanding and clinical management of these injuries .',
  'Brain concussion is a serious public health concern and is associated with short-term cognitive impairments and behavioral disturbances that typically occur in the absence of significant brain damage .',
  'Illicit use of anabolic androgenic steroids ( AAS ) has grown into a serious public health concern throughout the Western World .',
  'Doping in sports has become a serious problem .',
  'Concussion is a serious health concern .',
  'Although there has been a significant decrease in the overall rate of injury during the past 25 years , head injury remains a serious safety concern in motor sports and the greatest cause of death .',
  'Since the 1980s the use of AS has become prevalent among adults and adolescents who are concerned with muscle size and strength , and the abuse of these agents is regarded as a serious drug problem .',
  'Anabolic ergogenic substance use , in particular the use of anabolic androgenic steroids , is a serious problem in general .',
  'Sport and doping are a contradiction in terms , however , doping abuse in sports has been a serious problem for many years .',
  'Repeated concussion is becoming increasingly recognized as a serious public health concern around the world .',
  'Head injury , which annually affects 154 per 100,000 persons in Maryland , is a serious problem requiring attention from the medical community .',
  'Concussions remain a serious public health concern .',
  'Concussions remain a serious public health concern , with approximately 1.6 million to 3 million sport and recreational traumatic and brain injuries occurring every year in the United States .',
  'Brain concussions are a serious public concern and are associated with neuropsychiatric disorders , such as depression .',
  'Abuse of cocaine and androgenic-anabolic steroids has become a serious public health problem .',
  'Concussions in student-athletes are a serious problem .',
  'Apart from the nearly daily announcements on doping in sport there are ever increasing numbers of professionally employed people in vastly different functions and professions who make use of performance-enhancing substances : a serious social problem . It is not astonishing that even physicians and trauma surgeons who are under constant pressure from costs , time and performance demands also consume performance-enhancing drugs .',
  'Anabolic-androgenic steroid ( AAS ) use has been identified as a serious public health problem .',
  'Sports-related concussion , is a serious neurological concern that many adolescent athletes will face during their athletic careers .',
  'Cranio-cerebral traumatism occupies the first place among the causes of lethal outcomes and invalidism of the population and is a serious social-economic problem .',
  'Intentional misrepresentation , where athletes " cheat " on classification tests , remains a serious concern .',
  'For 86.5 % of the questioned physicians , doping is a serious public health problem and 60 % of them consider it as a kind of drug addiction .',
  'Concussions are occurring at alarming rates in the United States and have become a serious public health concern .',
  'The supply of human growth hormone now available to athletes seems small and costly , but drug testing experts agree that abuse of the substance could become a serious problem , especially if synthetic hormone becomes more widely available .',
  'Hematological manipulation to optimize aerobic performances is a serious problem in elite and professional sports and the approach to identify blood doping is as yet challenging .',
  'Underreporting of concussions and concussion-like symptoms in athletes continues to be a serious medical concern and research focus .',
  'Sports-related concussion ( SRC ) is a serious health concern .'],
 'sport': ['Abuse of cocaine and androgenic-anabolic steroids ( AASs ) has become a serious public health problem .',
  'Illicit use of anabolic androgenic steroids ( AAS ) has grown into a serious public health concern throughout the Western World .',
  'Doping in sports has become a serious problem .',
  'Since the 1980s the use of AS has become prevalent among adults and adolescents who are concerned with muscle size and strength , and the abuse of these agents is regarded as a serious drug problem .',
  'Anabolic ergogenic substance use , in particular the use of anabolic androgenic steroids , is a serious problem in general .',
  'Sport and doping are a contradiction in terms , however , doping abuse in sports has been a serious problem for many years .',
  'Abuse of cocaine and androgenic-anabolic steroids has become a serious public health problem .',
  'Apart from the nearly daily announcements on doping in sport there are ever increasing numbers of professionally employed people in vastly different functions and professions who make use of performance-enhancing substances : a serious social problem . It is not astonishing that even physicians and trauma surgeons who are under constant pressure from costs , time and performance demands also consume performance-enhancing drugs .',
  'Anabolic-androgenic steroid ( AAS ) use has been identified as a serious public health problem .',
  'Intentional misrepresentation , where athletes " cheat " on classification tests , remains a serious concern .',
  'For 86.5 % of the questioned physicians , doping is a serious public health problem and 60 % of them consider it as a kind of drug addiction .',
  'The supply of human growth hormone now available to athletes seems small and costly , but drug testing experts agree that abuse of the substance could become a serious problem , especially if synthetic hormone becomes more widely available .',
  'Hematological manipulation to optimize aerobic performances is a serious problem in elite and professional sports and the approach to identify blood doping is as yet challenging .'],
 'biofilms': ['The development of multi-species biofilms in chronic wounds is a serious health problem that primarily generates strong resistance mechanisms to antimicrobial therapy .',
  'Therefore , the biofilm formation , especially by multidrugresistant pathogens , is a serious medical problem , playing a pivotal role in the development of chronic and recurrent infections .',
  'Biofilms pose a serious problem for public health because of the increased resistance of biofilm-associated organisms to antimicrobial agents and the potential for these organisms to cause infections in patients with indwelling medical devices .',
  'High resistance of biofilms for chemical challenges is a serious industrial and medical problem .',
  'Biofilm formation in wounds is a serious problem which inhibits proper wound healing .',
  'Biofilm formation by Staphylococcus aureus is a serious problem in nosocomial infections .',
  'Bacterial cells at biofilm stage also are more tolerant to sanitizers compared   with their planktonic counterparts , which makes STEC biofilms a serious food safety concern .',
  'Nosocomial infections caused by biofilm-positive microorganisms are a serious therapeutic problem .',
  'Bacterial biofilms are a serious global health concern , often responsible for persistent infections .',
  'Biofilm formation in association with the intercellular adhesion ( icaADBC ) gene cluster is a serious problem in nosocomial infections of Staphylococcus aureus .',
  'Biofilm formation by Salmonella is a serious concern in the food-processing industry and the persistence of the organism in biofilms becomes a constant source of contamination .',
  'It represents a serious problem for the food industry because of its environmental persistence mainly due to its ability to form biofilm on a variety of surfaces .',
  'Nowadays , the resistance of bacterial biofilms towards the available antibiotics is a severe problem .',
  'Biofilms are considered as a severe problem in the treatment of bacterial infections ; their development causes some noticeable resistance to antibacterial agents .',
  'Bacterial biofilm cells are usually more resistant to sanitization than their planktonic counterparts , so these foodborne pathogens in biofilms pose a serious food safety concern .',
  "Biofilms ' tolerance has become a serious clinical concern due to their formidable resistance to conventional antibiotics and prevalent virulence .",
  'Biofilms formed by Proteus mirabilis strains are a serious medical problem , especially in the case of urinary tract infections .',
  'Biofilms are a serious problem of public health , because biofilm-associated microorganisms exhibit increased resistance to antibiotics .',
  'Biofilms are associated with a wide variety of bacterial infections and pose a serious problem in clinical medicine due to their inherent resilience to antibiotic treatment .',
  'Biofilm infections present a serious problem because antibacterial drugs are not effective against mature biofilms or biofilms formed by drug-resistant bacteria .',
  'Biofilms are a serious problem , cause of severe inconvenience in the biomedical , food and industrial environment .',
  'Biofilms in the food-processing industry are a serious concern due to the potential for contamination of food products , which may lead to decreased food quality and safety .',
  'This makes biofilms a serious problem in clinical settings .',
  'Staphylococcus aureus and its biofilm formation are recognized as a serious clinical problem .',
  'In Staphylococcus aureus ( S. aureus ) , biofilms are implicated in the resilience of chronic infections , presenting a serious clinical problem world-wide .',
  'Biofilms represent a serious problem for food industries due to their persistence in processing surfaces , from which they can cause food spoilage or , even worse , lead to foodborne diseases .',
  'Biofilm infections present a serious problem in human medicine as they often lead to bacterial persistence and thus to chronic infections .',
  'Bacterial infection has become a serious clinical concern due to the emergence of drug-resistance and biofilm formation .',
  'In the meat industry , biofilms remain a serious concern because many foodborne pathogens can form biofilms in areas at meat plants that are difficult to sanitize properly , and biofilm cells are more tolerant to sanitization than their planktonic counterparts .',
  'The rise of antibiotic resistance among biofilm-producer strains demonstrates a serious concern about limited treatment options in the \xa0 hospital settings .',
  'Given these anti-biofilm properties and considering that biofilm formation is a serious problem for the food industry and human health , PEOVW has proved to be a high-value natural product .',
  'Biofilms are the leading cause of microbial infections in humans , thus representing a serious problem in health care .',
  'Biofilm formation on foods and food industrial equipment is a serious problem causing food spoilage and emergence of foodborne diseases .',
  'Biofilm-related infections represent a serious health problem , accounting for 65- 80 % of all infections .',
  'Bacterial biofilms pose a serious medical problem due to their significant resistance to antimicrobials , and staphylococci are recognized as the most frequent cause of biofilm-associated infections .',
  'It is widely acknowledged that biofilm has become a serious problem in the food industry , as the biofilm growth mode induces microbial resistance to chemical disinfection .',
  'Biofilm tolerance has become a serious clinical concern in the treatment of nosocomial pneumonia owing to the resistance to various antibiotics .',
  'Biofilm represents a serious problem in food industry , since it is a constant and important contamination source and also , bacteria present in it have an increased resistance towards physical and chemical agents of common use .',
  'Bacterial biofilm development is a serious problem in many fields , and the existing biofilm monitoring sensors often turn out to be inadequate .'],
 'poisoning': ['The main hazard was found to be high transient concentrations of hydrogen sulphide presenting in some cases a serious acute toxicity problem .',
  'Deliberate self-poisoning by ingesting pesticides is a serious health problem among farmers , especially in low- and middle-income countries .',
  'Acute poisoning with this compound is common in some countries including India and Iran , and is a serious health problem .',
  'In 2008 , 1,007 cases of suicide in which hydrogen sulfide was used as a suicidal agent were reported in Japan , and this has become a serious social problem .',
  'It was shown that an enflurane vaporizer contaminated with halothane delivers potentially dangerous mixtures of the two agents , whereas an enflurane-contaminated halothane vaporizer does not pose a serious problem .',
  'Consumption of ponderosa pine needles causes late-term abortions in cattle and is a serious poisonous plant problem in foothill and mountain rangelands .',
  'Organic solvent inhalation is a serious problem among youths in Japan .',
  'Organic solvent neurotoxicity is a serious occupational health problem in Denmark .',
  'Interest in paracetamol poisoning as a serious clinical problem continues to grow .',
  'However , due to the frequent occurrence of poisoning incidents , their toxicity and safety have caused a serious concern .',
  'Organophosphorus agents ( OPA ) represent a serious concern to public safety as nerve agents and pesticides .',
  'Poisonings constitute a serious health problem in Norway .',
  'Mephedrone and chemsex : when it stops being a party and becomes a fatal problem .',
  'Ingestion of lye , a serious problem .',
  'In many countries these compounds present a serious social and health problem .',
  'Organophosphate/phosphonate ( OPP ) compounds represent a serious concern to public safety as nerve agents and pesticides .',
  'Pharmaceutical drug poisonings , especially those that are intentional , are a serious problem for adolescents and young adults .',
  'Increase in acute intoxication signs/symptoms and decrease in PChE indicate a serious public health problem among farmers who use organophosphate pesticides .',
  'Acute pesticide poisoning has long been a serious problem as a method of suicide worldwide .',
  'Intentional self-poisoning with pesticides is a serious problem in many developing countries .',
  'The poisoning by psychoactive drugs is increasinging in the recent years and organophosphates poisoning seems to be still a serious problem in such an agricultural area .',
  'Mass methanol poisonings present a serious problem for health systems worldwide , with poor outcome associated with delayed treatment .',
  'Poisonous plants are a serious problem for cattle breeding in Latin America .',
  'Pine needle-induced abortion in cattle is a serious problem in many areas of western United States and Canada .',
  'The lack of child-resistant packaging for this potentially toxic substance is a serious public health problem .',
  'Deliberate self-poisoning is a serious problem in Morocco , including in the Souss-Massa-Drâa region .',
  'Rapid increases in self-poisoning particularly among young adults present a serious public health problem .',
  'Pediatric poisoning has also been a serious problem during the 20th century .',
  'Organophosphate pesticides are used extensively worldwide , and poisoning by these agents , particularly in developing nations , is a serious public health problem .',
  'Deliberate self-poisoning ( DSP ) is a common cause of intensive care hospitalization among young adults and a serious health problem worldwide .',
  '[ GHB , GBL and butanediol poisonings -- a serious problem in Western Sweden ] .',
  'The effect of low-dose dichlorodiphenyltrichloroethane on the function of the immune system is a serious problem because of wide use of this pollutant .',
  'Cyanide ( CN ) toxicity is a serious clinical problem and can occur with sodium nitroprusside ( SNP ) administration , accidental smoke inhalation , industrial mishaps , and bio-terrorism .',
  'Developmental neurotoxicity ( DNT ) is a serious concern for environmental chemicals , as well as for food and drug constituents .',
  'Frequently the initial and only indication that a severe problem exists with peracute poisoning in a cattle herd is dead animals .',
  'The antidotal treatment of tabun acute poisonings still represents a serious problem and the development of new , more effective AChE reactivators to achieve the satisfactorily effective antidotal treatment of acute poisonings with tabun still represents very important goal .',
  'Acute poisoning is a serious health problem that is associated with high mortality .',
  'Acute kerosene poisoning is a preventable health problem in children perceived mainly in developing countries .',
  'Organophosphorus compounds have been widely employed to the development of warfare nerve agents and pesticides , resulting in a huge number of people intoxicated annually , being a serious problem of public health .',
  'The abuse of alkyl nitrites is becoming a serious social problem worldwide .',
  'Pesticide and rodenticide poisonings , whether intentional or unintentional , pose a serious threat to populations , and the availability of a banned rodenticide such as tetramethylenedisulfotetramine , with its associated morbidity and lethality , is a serious public health concern .',
  'Conclusion Corrosive ingestion is a serious medical problem and it requires a \xa0 multidisciplinary approach and a good coordination between different medical specialists .',
  'Although methodological problems constitute a major limitation in interpretation of the results , the literature indicates that parasuicide is a serious public health problem .',
  'However , the toxicity of CPAs is a serious concern and often requires rapid removal on thawing which is time consuming and expensive .',
  'Participants viewed poisoning as a serious problem to which all children are susceptible .',
  'Acute corrosive poisonings represent a serious socio-economic problem , as well as a diagnostic and therapeutic problem .',
  'The inactivation of acetylcholinesterase ( AChE ) by organophosphorus agent ( OP ) compounds is a serious problem regardless of how the individual was exposed .',
  'Tall larkspur ( Delphinium spp . ) is a serious toxic plant problem on western U.S. ranges .',
  'Hydrogen sulphide ( H2S ) , a chemical hazard in oil and gas production , has recently become a dreadful method of suicide , posing specific risks and challenges for the first responders .',
  'As a devastating holoparasitic weed , Orobanche aegyptiaca Persoon . ( Egyptian broomrape ) causes serious damage to agricultural production and threatens economic development , which has raised widespread concern .',
  'The contamination of green fodder with houndstongue can be a serious problem for the feeding practice in certain regions ( dry grassland , loess or shell lime soil , extensive management ) .',
  'Accidental poisonings remain a serious problem among young children .',
  'Methanol poisoning continues to be a serious problem in Iran ; however , there is not yet any report of the prevalence of methanol intoxication .',
  'Exposure to organophosphorus ( OP ) pesticides represents a severe health issue in developing countries , while OP intoxication with the more lethal military nerve agents is not only of military concern but also a terrorist threat .',
  'Glue and thinner sniffing is a serious medical problem since the volatile constituents of these substances can lead to severe damage to bone marrow , liver , kidney , brain , and heart .',
  'Subacute poisoning of 1,2-dichloroethane ( 1,2-DCE ) has become a serious occupational problem in China , and brain edema is its main pathological consequence , but little is known about the underlying mechanisms .',
  'Larkspurs ( Delphinium spp . ) are a serious toxic plant problem for cattle in western North America .',
  'Organic solvent-induced neurodegeneration is a severe public health problem which has no effective prevention measures yet .',
  'Acute paediatric poisonings represent a relatively frequent problem in Finland , and remain a life-threatening problem .',
  'Drug-induced poisoning of children represents a serious medical as well as a social problem linked both to the fields of prevention and therapy .',
  'Tall larkspur poisoning of cattle is a serious problem on western US rangelands .',
  'Larkspur ( Delphinium sp ) poisoning of range cattle is a serious , recurring problem in the western United States .',
  'Exposure to toxic organophosphorus pesticides ( OPP ) represents a serious problem in the public healthcare sector and might be forced in terroristic attacks .',
  'Exposure to organic solvents is a serious occupational health problem .',
  'Locoweed species ( Astragalus and Oxytropis spp . ) are a serious toxic plant problem for grazing livestock .',
  'In Republic of Korea , organic solvent abuse is a serious social problem , especially among teenagers .',
  'This evidence and the recent identification of nitrosamine impurities classified as probable human carcinogens in several angiotensin receptor blockers confirm that the presence of low-quality/substandard GMPs represents a serious public health problem with significant impact on national clinical and economic burden .',
  'Self-poisoning in children is a serious health concern accounting for 2 % and 5 % of childhood deaths in the developed and developing world , respectively .',
  'Childhood unintentional and suspected poisonings are a serious public health problem .',
  'However , toxicity to human cells due to their physico-chemical properties is a serious public health concern .',
  'A serious , relatively unrecognized , occupational health problem involves the interaction of ethyl alcohol and chemical agents used in industry .',
  'Poisoning by these agents , either as acute or chronic in these nations , is a serious health problem .',
  'Locoweed ( Oxytropis sericea ) is a serious poisoning problem for horses grazing on infested rangelands in the western United States .',
  'Human poisoning is a serious problem in Taiwan .',
  'Acute poisoning with gamma-hydroxybutyrate ( GHB ) has been a serious medical and social problem in different parts of the world including Sweden .',
  'Organophosphate ( OP ) intoxication remains a serious worldwide health concern , and many patients with acute OP intoxication have also consumed alcohol .',
  'Poisoning by these agents is a serious public health problem .',
  'Acute poisonings remain a severe problem .',
  'Chemsex and slamsex represent a serious public health concern that has to be considered by both clinical and forensic toxicologists .',
  'Morbidity and mortality related to acute poisoning is a serious health concern worldwide .',
  'Poisoning as a serious problem .',
  'Organophosphorus pesticides have largely been used worldwide , and poisoning by these agents , particularly in developing countries , is a serious health problem .',
  'Salicylate poisoning is a serious toxicologic problem with a complex pathophysiology that requires prompt diagnosis and action for a favorable outcome .',
  'Accidental poisoning by oral iron preparations is a serious problem in young children .',
  'Accidental or intentional poisonings with ethylene glycol or methanol constitute a serious toxicological problem in many countries .',
  'Poisoning by means of hazardous chemicals through ignorance , mishap or intentionally is becoming a serious health problem worldwide .'],
 'poisonings': ['The main hazard was found to be high transient concentrations of hydrogen sulphide presenting in some cases a serious acute toxicity problem .',
  'Acute poisoning with this compound is common in some countries including India and Iran , and is a serious health problem .',
  'In 2008 , 1,007 cases of suicide in which hydrogen sulfide was used as a suicidal agent were reported in Japan , and this has become a serious social problem .',
  'It was shown that an enflurane vaporizer contaminated with halothane delivers potentially dangerous mixtures of the two agents , whereas an enflurane-contaminated halothane vaporizer does not pose a serious problem .',
  'Organic solvent inhalation is a serious problem among youths in Japan .',
  'Organic solvent neurotoxicity is a serious occupational health problem in Denmark .',
  'Interest in paracetamol poisoning as a serious clinical problem continues to grow .',
  'However , due to the frequent occurrence of poisoning incidents , their toxicity and safety have caused a serious concern .',
  'Poisonings constitute a serious health problem in Norway .',
  'Mephedrone and chemsex : when it stops being a party and becomes a fatal problem .',
  'Ingestion of lye , a serious problem .',
  'In many countries these compounds present a serious social and health problem .',
  'Pharmaceutical drug poisonings , especially those that are intentional , are a serious problem for adolescents and young adults .',
  'Mass methanol poisonings present a serious problem for health systems worldwide , with poor outcome associated with delayed treatment .',
  'The lack of child-resistant packaging for this potentially toxic substance is a serious public health problem .',
  'Deliberate self-poisoning is a serious problem in Morocco , including in the Souss-Massa-Drâa region .',
  'Rapid increases in self-poisoning particularly among young adults present a serious public health problem .',
  'Pediatric poisoning has also been a serious problem during the 20th century .',
  'Deliberate self-poisoning ( DSP ) is a common cause of intensive care hospitalization among young adults and a serious health problem worldwide .',
  '[ GHB , GBL and butanediol poisonings -- a serious problem in Western Sweden ] .',
  'The effect of low-dose dichlorodiphenyltrichloroethane on the function of the immune system is a serious problem because of wide use of this pollutant .',
  'Cyanide ( CN ) toxicity is a serious clinical problem and can occur with sodium nitroprusside ( SNP ) administration , accidental smoke inhalation , industrial mishaps , and bio-terrorism .',
  'Developmental neurotoxicity ( DNT ) is a serious concern for environmental chemicals , as well as for food and drug constituents .',
  'The antidotal treatment of tabun acute poisonings still represents a serious problem and the development of new , more effective AChE reactivators to achieve the satisfactorily effective antidotal treatment of acute poisonings with tabun still represents very important goal .',
  'Acute poisoning is a serious health problem that is associated with high mortality .',
  'Acute kerosene poisoning is a preventable health problem in children perceived mainly in developing countries .',
  'The abuse of alkyl nitrites is becoming a serious social problem worldwide .',
  'Conclusion Corrosive ingestion is a serious medical problem and it requires a \xa0 multidisciplinary approach and a good coordination between different medical specialists .',
  'However , the toxicity of CPAs is a serious concern and often requires rapid removal on thawing which is time consuming and expensive .',
  'Participants viewed poisoning as a serious problem to which all children are susceptible .',
  'Acute corrosive poisonings represent a serious socio-economic problem , as well as a diagnostic and therapeutic problem .',
  'Hydrogen sulphide ( H2S ) , a chemical hazard in oil and gas production , has recently become a dreadful method of suicide , posing specific risks and challenges for the first responders .',
  'Accidental poisonings remain a serious problem among young children .',
  'Methanol poisoning continues to be a serious problem in Iran ; however , there is not yet any report of the prevalence of methanol intoxication .',
  'Glue and thinner sniffing is a serious medical problem since the volatile constituents of these substances can lead to severe damage to bone marrow , liver , kidney , brain , and heart .',
  'Subacute poisoning of 1,2-dichloroethane ( 1,2-DCE ) has become a serious occupational problem in China , and brain edema is its main pathological consequence , but little is known about the underlying mechanisms .',
  'Organic solvent-induced neurodegeneration is a severe public health problem which has no effective prevention measures yet .',
  'Acute paediatric poisonings represent a relatively frequent problem in Finland , and remain a life-threatening problem .',
  'Drug-induced poisoning of children represents a serious medical as well as a social problem linked both to the fields of prevention and therapy .',
  'Exposure to organic solvents is a serious occupational health problem .',
  'In Republic of Korea , organic solvent abuse is a serious social problem , especially among teenagers .',
  'This evidence and the recent identification of nitrosamine impurities classified as probable human carcinogens in several angiotensin receptor blockers confirm that the presence of low-quality/substandard GMPs represents a serious public health problem with significant impact on national clinical and economic burden .',
  'Self-poisoning in children is a serious health concern accounting for 2 % and 5 % of childhood deaths in the developed and developing world , respectively .',
  'Childhood unintentional and suspected poisonings are a serious public health problem .',
  'However , toxicity to human cells due to their physico-chemical properties is a serious public health concern .',
  'A serious , relatively unrecognized , occupational health problem involves the interaction of ethyl alcohol and chemical agents used in industry .',
  'Poisoning by these agents , either as acute or chronic in these nations , is a serious health problem .',
  'Human poisoning is a serious problem in Taiwan .',
  'Acute poisoning with gamma-hydroxybutyrate ( GHB ) has been a serious medical and social problem in different parts of the world including Sweden .',
  'Poisoning by these agents is a serious public health problem .',
  'Acute poisonings remain a severe problem .',
  'Chemsex and slamsex represent a serious public health concern that has to be considered by both clinical and forensic toxicologists .',
  'Morbidity and mortality related to acute poisoning is a serious health concern worldwide .',
  'Poisoning as a serious problem .',
  'Salicylate poisoning is a serious toxicologic problem with a complex pathophysiology that requires prompt diagnosis and action for a favorable outcome .',
  'Accidental poisoning by oral iron preparations is a serious problem in young children .',
  'Accidental or intentional poisonings with ethylene glycol or methanol constitute a serious toxicological problem in many countries .',
  'Poisoning by means of hazardous chemicals through ignorance , mishap or intentionally is becoming a serious health problem worldwide .'],
 'drainage': ['Acid mine drainage ( AMD ) is a serious environmental problem in the mining industry .',
  'The presence of high concentrations of sulfate , iron , and hydrogen ( acid ) ions in drainage from coal mines and other areas containing waste pyritic materials is a serious water pollution problem .',
  'Acid mine/rock drainage ( AMD/ARD ) , effluents with low pH and high concentrations of hazardous and toxic elements generated when sulfide-rich wastes are exposed to the environment , is considered as a serious environmental problem encountered by the mining and mineral processing industries around the world .',
  'Acid mine drainage ( AMD ) is a serious environmental problem resulting from extensive sulfide mining activities .',
  'Acid mine drainage ( AMD ) , an acidic metal-bearing wastewater , poses a severe pollution problem attributed to post mining activities .',
  'The environmental contamination due to mining activities in the Andean region of Bolivia is a serious concern , as it leads to highly acidic ( pH 2.4 ) acid mine drainage ( AMD ) , severely polluted by sulfate ( > 12,000 \u2005 mg \u2005 L',
  'Acid mine drainage ( AMD ) generated from mining activities has been recognized as a serious problem due to its increased acidity and high concentration of heavy metals .',
  'Acid mine drainage ( AMD ) , which contains high concentrations of sulphate and dissolved metals , is a serious environmental problem .',
  'Details are presented of scientific investigations , and a lime-assisted tidal exchange strategy that are being undertaken to remediate a serious ASS problem .',
  'Acid mine drainage ( AMD ) is a serious environmental problem that creates acidic solution with high Mn concentrations .',
  'It is also the primary cause of acid mine drainage ( AMD ) that is considered as a serious and widespread problem facing the mining and mineral processing industries .',
  'Contaminated drainage from metal mines is a serious water-quality problem facing nations that exploit metal mineral resources .',
  'Metal contamination from acid mine drainage ( AMD ) is a serious problem in the southwest of the Iberian Peninsula , where the Iberian Pyrite Belt is located .'],
 'mining': ['Acid mine drainage ( AMD ) is a serious environmental problem in the mining industry .',
  'The presence of high concentrations of sulfate , iron , and hydrogen ( acid ) ions in drainage from coal mines and other areas containing waste pyritic materials is a serious water pollution problem .',
  'Acid mine/rock drainage ( AMD/ARD ) , effluents with low pH and high concentrations of hazardous and toxic elements generated when sulfide-rich wastes are exposed to the environment , is considered as a serious environmental problem encountered by the mining and mineral processing industries around the world .',
  'Acid mine drainage ( AMD ) is a serious environmental problem resulting from extensive sulfide mining activities .',
  'Acid mine drainage ( AMD ) , an acidic metal-bearing wastewater , poses a severe pollution problem attributed to post mining activities .',
  'The environmental contamination due to mining activities in the Andean region of Bolivia is a serious concern , as it leads to highly acidic ( pH 2.4 ) acid mine drainage ( AMD ) , severely polluted by sulfate ( > 12,000 \u2005 mg \u2005 L',
  'Acid mine drainage ( AMD ) generated from mining activities has been recognized as a serious problem due to its increased acidity and high concentration of heavy metals .',
  'Acid mine drainage ( AMD ) , which contains high concentrations of sulphate and dissolved metals , is a serious environmental problem .',
  'Details are presented of scientific investigations , and a lime-assisted tidal exchange strategy that are being undertaken to remediate a serious ASS problem .',
  'Acid mine drainage ( AMD ) is a serious environmental problem that creates acidic solution with high Mn concentrations .',
  'It is also the primary cause of acid mine drainage ( AMD ) that is considered as a serious and widespread problem facing the mining and mineral processing industries .',
  'Contaminated drainage from metal mines is a serious water-quality problem facing nations that exploit metal mineral resources .',
  'Metal contamination from acid mine drainage ( AMD ) is a serious problem in the southwest of the Iberian Peninsula , where the Iberian Pyrite Belt is located .'],
 'acidic': ['Acid mine drainage ( AMD ) is a serious environmental problem in the mining industry .',
  'The presence of high concentrations of sulfate , iron , and hydrogen ( acid ) ions in drainage from coal mines and other areas containing waste pyritic materials is a serious water pollution problem .',
  'Acid mine/rock drainage ( AMD/ARD ) , effluents with low pH and high concentrations of hazardous and toxic elements generated when sulfide-rich wastes are exposed to the environment , is considered as a serious environmental problem encountered by the mining and mineral processing industries around the world .',
  'Acid mine drainage ( AMD ) is a serious environmental problem resulting from extensive sulfide mining activities .',
  'Acid mine drainage ( AMD ) , an acidic metal-bearing wastewater , poses a severe pollution problem attributed to post mining activities .',
  'The environmental contamination due to mining activities in the Andean region of Bolivia is a serious concern , as it leads to highly acidic ( pH 2.4 ) acid mine drainage ( AMD ) , severely polluted by sulfate ( > 12,000 \u2005 mg \u2005 L',
  'Acid mine drainage ( AMD ) generated from mining activities has been recognized as a serious problem due to its increased acidity and high concentration of heavy metals .',
  'Acid mine drainage ( AMD ) , which contains high concentrations of sulphate and dissolved metals , is a serious environmental problem .',
  'Details are presented of scientific investigations , and a lime-assisted tidal exchange strategy that are being undertaken to remediate a serious ASS problem .',
  'Acid mine drainage ( AMD ) is a serious environmental problem that creates acidic solution with high Mn concentrations .',
  'It is also the primary cause of acid mine drainage ( AMD ) that is considered as a serious and widespread problem facing the mining and mineral processing industries .',
  'Contaminated drainage from metal mines is a serious water-quality problem facing nations that exploit metal mineral resources .',
  'Metal contamination from acid mine drainage ( AMD ) is a serious problem in the southwest of the Iberian Peninsula , where the Iberian Pyrite Belt is located .'],
 'mineral': ['Acid mine drainage ( AMD ) is a serious environmental problem in the mining industry .',
  'The presence of high concentrations of sulfate , iron , and hydrogen ( acid ) ions in drainage from coal mines and other areas containing waste pyritic materials is a serious water pollution problem .',
  'Acid mine/rock drainage ( AMD/ARD ) , effluents with low pH and high concentrations of hazardous and toxic elements generated when sulfide-rich wastes are exposed to the environment , is considered as a serious environmental problem encountered by the mining and mineral processing industries around the world .',
  'Acid mine drainage ( AMD ) is a serious environmental problem resulting from extensive sulfide mining activities .',
  'Acid mine drainage ( AMD ) , an acidic metal-bearing wastewater , poses a severe pollution problem attributed to post mining activities .',
  'The environmental contamination due to mining activities in the Andean region of Bolivia is a serious concern , as it leads to highly acidic ( pH 2.4 ) acid mine drainage ( AMD ) , severely polluted by sulfate ( > 12,000 \u2005 mg \u2005 L',
  'Acid mine drainage ( AMD ) generated from mining activities has been recognized as a serious problem due to its increased acidity and high concentration of heavy metals .',
  'Acid mine drainage ( AMD ) , which contains high concentrations of sulphate and dissolved metals , is a serious environmental problem .',
  'Details are presented of scientific investigations , and a lime-assisted tidal exchange strategy that are being undertaken to remediate a serious ASS problem .',
  'Acid mine drainage ( AMD ) is a serious environmental problem that creates acidic solution with high Mn concentrations .',
  'It is also the primary cause of acid mine drainage ( AMD ) that is considered as a serious and widespread problem facing the mining and mineral processing industries .',
  'Contaminated drainage from metal mines is a serious water-quality problem facing nations that exploit metal mineral resources .',
  'Metal contamination from acid mine drainage ( AMD ) is a serious problem in the southwest of the Iberian Peninsula , where the Iberian Pyrite Belt is located .'],
 'zika': ['The Zika virus ( ZIKV ) is a mosquito-borne flavivirus that has reemerged as a serious public health problem around the world .',
  'Zika virus ( ZIKV ) infection is a serious public health concern .',
  'World Health Organization ( WHO ) has considered transmission of ZIKV , a serious public health problem because of the increasing number of outbreaks .',
  'Zika virus ( ZIKV ) has become a serious public health concern because of its link to brain damage in developing human fetuses .',
  'Zika virus ( ZIKV ) infection is a serious public health concern due to its ability to induce neurological defects and its potential for rapid transmission at a global scale .',
  'Zika disease has transformed into a serious global health problem due to the rapid spread of the arbovirus and alarming severity including congenital complications , microcephaly and Guillain-Barré syndrome .',
  'Zika has developed into a serious global health problem because , while most cases are asymptomatic or very light , babies born to Zika - infected mothers may develop microcephaly and other very serious birth defects .',
  'The co-circulation of ZIKV and DENV is a serious public health concern , since it represents both a clinical and diagnostic challenge in endemic areas , as well as in the field of travel medicine .',
  'Zika virus ( ZIKV ) is a mosquito-borne flavivirus that has been associated with neuropathology in fetuses and adults , imposing a serious health concern .',
  'However , ZIKV became a serious public health concern in recent years due to an association with congenital malformation known as microcephaly in newborns as well as Guillain-Barré syndrome and other neurologic disorders in adults .',
  'Currently , the World Health Organization warns that the rapid spread of the virus Zika in both Americas and an increase in the number of children born with microcephaly in these regions begins to be a serious epidemiological problem .',
  'Zika virus ( ZIKV ) is a serious public health concern that may lead to neurological disorders in affected individuals .',
  'Currently , the World Health Organization warns that the rapid spread of the virus Zika in both Americas and an increase in the number of children born with microcephaly in these regions begins to be a serious epidemiological problem .'],
 'zikv': ['The Zika virus ( ZIKV ) is a mosquito-borne flavivirus that has reemerged as a serious public health problem around the world .',
  'Zika virus ( ZIKV ) infection is a serious public health concern .',
  'World Health Organization ( WHO ) has considered transmission of ZIKV , a serious public health problem because of the increasing number of outbreaks .',
  'Zika virus ( ZIKV ) has become a serious public health concern because of its link to brain damage in developing human fetuses .',
  'Zika virus ( ZIKV ) infection is a serious public health concern due to its ability to induce neurological defects and its potential for rapid transmission at a global scale .',
  'Zika disease has transformed into a serious global health problem due to the rapid spread of the arbovirus and alarming severity including congenital complications , microcephaly and Guillain-Barré syndrome .',
  'Zika has developed into a serious global health problem because , while most cases are asymptomatic or very light , babies born to Zika - infected mothers may develop microcephaly and other very serious birth defects .',
  'The co-circulation of ZIKV and DENV is a serious public health concern , since it represents both a clinical and diagnostic challenge in endemic areas , as well as in the field of travel medicine .',
  'Zika virus ( ZIKV ) is a mosquito-borne flavivirus that has been associated with neuropathology in fetuses and adults , imposing a serious health concern .',
  'However , ZIKV became a serious public health concern in recent years due to an association with congenital malformation known as microcephaly in newborns as well as Guillain-Barré syndrome and other neurologic disorders in adults .',
  'Currently , the World Health Organization warns that the rapid spread of the virus Zika in both Americas and an increase in the number of children born with microcephaly in these regions begins to be a serious epidemiological problem .',
  'Zika virus ( ZIKV ) is a serious public health concern that may lead to neurological disorders in affected individuals .',
  'Currently , the World Health Organization warns that the rapid spread of the virus Zika in both Americas and an increase in the number of children born with microcephaly in these regions begins to be a serious epidemiological problem .'],
 'microcephaly': ['The Zika virus ( ZIKV ) is a mosquito-borne flavivirus that has reemerged as a serious public health problem around the world .',
  'Zika virus ( ZIKV ) infection is a serious public health concern .',
  'World Health Organization ( WHO ) has considered transmission of ZIKV , a serious public health problem because of the increasing number of outbreaks .',
  'Zika virus ( ZIKV ) has become a serious public health concern because of its link to brain damage in developing human fetuses .',
  'Zika virus ( ZIKV ) infection is a serious public health concern due to its ability to induce neurological defects and its potential for rapid transmission at a global scale .',
  'Zika disease has transformed into a serious global health problem due to the rapid spread of the arbovirus and alarming severity including congenital complications , microcephaly and Guillain-Barré syndrome .',
  'Zika has developed into a serious global health problem because , while most cases are asymptomatic or very light , babies born to Zika - infected mothers may develop microcephaly and other very serious birth defects .',
  'The co-circulation of ZIKV and DENV is a serious public health concern , since it represents both a clinical and diagnostic challenge in endemic areas , as well as in the field of travel medicine .',
  'Zika virus ( ZIKV ) is a mosquito-borne flavivirus that has been associated with neuropathology in fetuses and adults , imposing a serious health concern .',
  'However , ZIKV became a serious public health concern in recent years due to an association with congenital malformation known as microcephaly in newborns as well as Guillain-Barré syndrome and other neurologic disorders in adults .',
  'Currently , the World Health Organization warns that the rapid spread of the virus Zika in both Americas and an increase in the number of children born with microcephaly in these regions begins to be a serious epidemiological problem .',
  'Zika virus ( ZIKV ) is a serious public health concern that may lead to neurological disorders in affected individuals .',
  'Currently , the World Health Organization warns that the rapid spread of the virus Zika in both Americas and an increase in the number of children born with microcephaly in these regions begins to be a serious epidemiological problem .'],
 'tamoxifen': ['Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients .',
  'Resistance to tamoxifen in breast cancer patients is a serious therapeutic problem and major efforts are underway to understand underlying mechanisms .',
  'Tamoxifen resistance ( TAMr ) in breast cancer is a serious clinical dilemma , with no satisfactory explanation .',
  'However , acquisition of resistance to tamoxifen in one third of patients presents a serious clinical problem .',
  'Development of resistance to antiestrogen treatment in breast cancer patients is a serious therapeutic problem .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients .',
  'Tamoxifen ( TAM ) resistance is a serious clinical problem in the treatment of breast cancer .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients , and Her-2/ErbB2 expression is associated with decreased sensitivity to TAM .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients .',
  'Development of resistance to tamoxifen is a serious problem in treatment of breast cancer patients .',
  'Tumor resistance to the selective estrogen receptor modulator tamoxifen remains a serious clinical problem especially in patients with tumors that also overexpress HER2 .',
  'Development of resistance to therapy continues to be a serious clinical problem in breast cancer management .',
  'Acquired resistance to tamoxifen in breast cancer patients is a serious therapeutic problem .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients .',
  'Tamoxifen resistance is often observed in the majority of estrogen receptor-positive breast cancers and it remains as a serious clinical problem in breast cancer management .',
  'Acquired resistance to doxorubicin ( DOX ) is a serious therapeutic problem in breast cancer patients .',
  'Development of acquired resistance against antiestrogen treatment is a serious problem in human breast cancer , and knowledge of alterations resulting in resistance is important for selection of further treatment .',
  'Tamoxifen resistance is a serious clinical problem commonly encountered in the management of patients with breast cancer .',
  'Acquired resistance to doxorubicin in breast cancer is a serious therapeutic problem .',
  'Tamoxifen resistance is a serious problem in the endocrine therapy of breast cancer .',
  'A considerable proportion of estrogen receptor (ER)-positive breast cancer recurs despite tamoxifen treatment , which is a serious problem commonly encountered in clinical practice .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem among estrogen-receptor-positive breast cancer patients .',
  'Breast cancer patients with an estrogen receptor ( ER ) positive tumor can be treated with the anti-estrogen tamoxifen , but development of anti-estrogen resistance is a serious problem .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem among breast cancer patients .',
  'Tumor resistance to tamoxifen remains a serious clinical problem especially in patients with tumors that also overexpress human epidermal growth factor receptor 2 ( HER2 ) .',
  'Acquired resistance to tamoxifen ( Tam ) in breast cancer patients is a serious therapeutic problem .'],
 'estrogen': ['Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients .',
  'Resistance to tamoxifen in breast cancer patients is a serious therapeutic problem and major efforts are underway to understand underlying mechanisms .',
  'Tamoxifen resistance ( TAMr ) in breast cancer is a serious clinical dilemma , with no satisfactory explanation .',
  'However , acquisition of resistance to tamoxifen in one third of patients presents a serious clinical problem .',
  'Development of resistance to antiestrogen treatment in breast cancer patients is a serious therapeutic problem .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients .',
  'Tamoxifen ( TAM ) resistance is a serious clinical problem in the treatment of breast cancer .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients , and Her-2/ErbB2 expression is associated with decreased sensitivity to TAM .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients .',
  'Development of resistance to tamoxifen is a serious problem in treatment of breast cancer patients .',
  'Tumor resistance to the selective estrogen receptor modulator tamoxifen remains a serious clinical problem especially in patients with tumors that also overexpress HER2 .',
  'Development of resistance to therapy continues to be a serious clinical problem in breast cancer management .',
  'Acquired resistance to tamoxifen in breast cancer patients is a serious therapeutic problem .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients .',
  'Tamoxifen resistance is often observed in the majority of estrogen receptor-positive breast cancers and it remains as a serious clinical problem in breast cancer management .',
  'Acquired resistance to doxorubicin ( DOX ) is a serious therapeutic problem in breast cancer patients .',
  'Development of acquired resistance against antiestrogen treatment is a serious problem in human breast cancer , and knowledge of alterations resulting in resistance is important for selection of further treatment .',
  'Tamoxifen resistance is a serious clinical problem commonly encountered in the management of patients with breast cancer .',
  'Acquired resistance to doxorubicin in breast cancer is a serious therapeutic problem .',
  'Tamoxifen resistance is a serious problem in the endocrine therapy of breast cancer .',
  'A considerable proportion of estrogen receptor (ER)-positive breast cancer recurs despite tamoxifen treatment , which is a serious problem commonly encountered in clinical practice .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem among estrogen-receptor-positive breast cancer patients .',
  'Breast cancer patients with an estrogen receptor ( ER ) positive tumor can be treated with the anti-estrogen tamoxifen , but development of anti-estrogen resistance is a serious problem .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem among breast cancer patients .',
  'Tumor resistance to tamoxifen remains a serious clinical problem especially in patients with tumors that also overexpress human epidermal growth factor receptor 2 ( HER2 ) .',
  'Acquired resistance to tamoxifen ( Tam ) in breast cancer patients is a serious therapeutic problem .'],
 'receptor': ['Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients .',
  'Resistance to tamoxifen in breast cancer patients is a serious therapeutic problem and major efforts are underway to understand underlying mechanisms .',
  'Tamoxifen resistance ( TAMr ) in breast cancer is a serious clinical dilemma , with no satisfactory explanation .',
  'However , acquisition of resistance to tamoxifen in one third of patients presents a serious clinical problem .',
  'Development of resistance to antiestrogen treatment in breast cancer patients is a serious therapeutic problem .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients .',
  'Tamoxifen ( TAM ) resistance is a serious clinical problem in the treatment of breast cancer .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients , and Her-2/ErbB2 expression is associated with decreased sensitivity to TAM .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients .',
  'Development of resistance to tamoxifen is a serious problem in treatment of breast cancer patients .',
  'Tumor resistance to the selective estrogen receptor modulator tamoxifen remains a serious clinical problem especially in patients with tumors that also overexpress HER2 .',
  'Development of resistance to therapy continues to be a serious clinical problem in breast cancer management .',
  'Acquired resistance to tamoxifen in breast cancer patients is a serious therapeutic problem .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem in breast cancer patients .',
  'Tamoxifen resistance is often observed in the majority of estrogen receptor-positive breast cancers and it remains as a serious clinical problem in breast cancer management .',
  'Acquired resistance to doxorubicin ( DOX ) is a serious therapeutic problem in breast cancer patients .',
  'Development of acquired resistance against antiestrogen treatment is a serious problem in human breast cancer , and knowledge of alterations resulting in resistance is important for selection of further treatment .',
  'Tamoxifen resistance is a serious clinical problem commonly encountered in the management of patients with breast cancer .',
  'Acquired resistance to doxorubicin in breast cancer is a serious therapeutic problem .',
  'Tamoxifen resistance is a serious problem in the endocrine therapy of breast cancer .',
  'A considerable proportion of estrogen receptor (ER)-positive breast cancer recurs despite tamoxifen treatment , which is a serious problem commonly encountered in clinical practice .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem among estrogen-receptor-positive breast cancer patients .',
  'Breast cancer patients with an estrogen receptor ( ER ) positive tumor can be treated with the anti-estrogen tamoxifen , but development of anti-estrogen resistance is a serious problem .',
  'Acquired resistance to tamoxifen ( TAM ) is a serious therapeutic problem among breast cancer patients .',
  'Tumor resistance to tamoxifen remains a serious clinical problem especially in patients with tumors that also overexpress human epidermal growth factor receptor 2 ( HER2 ) .',
  'Acquired resistance to tamoxifen ( Tam ) in breast cancer patients is a serious therapeutic problem .'],
 'asbestos': ['While industrial hygienists recognized in the early 1900s that chronic and high-level exposures to airborne concentrations of asbestos could pose a serious health hazard , it was not until the mid-1950s that the carcinogenic nature of asbestos began to be characterized and widespread concern followed .',
  'The natural occurrence of asbestos ( NOA ) in rural areas is a serious concern for human health and the dispersion route of asbestos in the proximity of natural asbestos-rich settings has been marginally evaluated so far .',
  'Asbestos-containing materials that are now banned or regulated are still present in older buildings and remain an exposure hazard ; they continue to be a serious health concern in many countries .',
  'Both asbestos and erionite related malignant pleural mesothelioma ( MPM ) is a serious health problem in Turkey .',
  'Asbestos exposure in rural areas continues to be a serious problem in Turkey , which obviates the necessity for effective preventive measures .',
  'The current findings suggest that environmental asbestos exposure continue to be a serious health concern in the Gaziantep region of Turkey .',
  'High concentrations of airborne asbestos in the ambient air are still a serious problem of air quality in numerous localities around the world .',
  'Results confirm that over eighteen years after the entry into force of Law 257/1992 , which established the cessation of all activities related to asbestos , asbestos-related diseases continue being observed in clinical practice and represent a serious public health problem .',
  'To determine whether local environmental exposure to asbestos in the community of Hof van Twente , The Netherlands ( which houses a large asbestos cement facility and has a serious environmental asbestos pollution problem ) , is accompanied by an increased mortality due to pleural mesothelioma among women .',
  'By the early 1900s there was evidence that the asbestos substituted for the man-made mineral fiber insulation material employed to improve the thermal efficiency of steam powered engines , presented a serious health problem .',
  'Likewise , the environmental pollution from asbestos waste landfills in the vicinity of asbestos-processing plants ( where high levels of asbestos fibre in ambient air have been recorded ) will continue to be a serious public health problem .'],
 '1900s': ['While industrial hygienists recognized in the early 1900s that chronic and high-level exposures to airborne concentrations of asbestos could pose a serious health hazard , it was not until the mid-1950s that the carcinogenic nature of asbestos began to be characterized and widespread concern followed .',
  'The natural occurrence of asbestos ( NOA ) in rural areas is a serious concern for human health and the dispersion route of asbestos in the proximity of natural asbestos-rich settings has been marginally evaluated so far .',
  'Asbestos-containing materials that are now banned or regulated are still present in older buildings and remain an exposure hazard ; they continue to be a serious health concern in many countries .',
  'Both asbestos and erionite related malignant pleural mesothelioma ( MPM ) is a serious health problem in Turkey .',
  'Asbestos exposure in rural areas continues to be a serious problem in Turkey , which obviates the necessity for effective preventive measures .',
  'The current findings suggest that environmental asbestos exposure continue to be a serious health concern in the Gaziantep region of Turkey .',
  'High concentrations of airborne asbestos in the ambient air are still a serious problem of air quality in numerous localities around the world .',
  'Results confirm that over eighteen years after the entry into force of Law 257/1992 , which established the cessation of all activities related to asbestos , asbestos-related diseases continue being observed in clinical practice and represent a serious public health problem .',
  'To determine whether local environmental exposure to asbestos in the community of Hof van Twente , The Netherlands ( which houses a large asbestos cement facility and has a serious environmental asbestos pollution problem ) , is accompanied by an increased mortality due to pleural mesothelioma among women .',
  'By the early 1900s there was evidence that the asbestos substituted for the man-made mineral fiber insulation material employed to improve the thermal efficiency of steam powered engines , presented a serious health problem .',
  'Likewise , the environmental pollution from asbestos waste landfills in the vicinity of asbestos-processing plants ( where high levels of asbestos fibre in ambient air have been recorded ) will continue to be a serious public health problem .'],
 'erosion': ['Soil erosion is a serious environmental problem in Guizhou Province , which is located in the centre of the karst areas of southwestern China .',
  'Rangeland degradation has been identified as a serious concern in alpine regions of western China on the Qinghai-Tibetan plateau ( QTP ) .',
  'Soil degradation through erosion and desertification reduces soil productivity , and is a serious problem in agricultural production of China .',
  'Soil compaction is a serious global problem , and is a major cause of inadequate rooting and poor yield in crops around the world .',
  'Land degradation by water and wind erosion is a serious problem worldwide .',
  'Road embankments erosion is a serious problem in Spain .',
  'Soil erosion has become a serious problem in recent decades due to unhalted trends of unsustainable land use practices .',
  'Soil erosion is a severe problem for many developing regions that lack adequate infrastructure to combat the problem .',
  'Soil erosion has become a serious ecological problem in many catchments .',
  'Erosion of denuded steep rocky slopes causes increasing losses of nitrogen and phosphorus , which is a severe problem in rocky slope protection .',
  'Development and land use change lead to accelerated soil erosion as a serious environmental problem in river catchments in Iran .',
  'Such erosion has become a serious problem in China .',
  'The risk of the desertification of a part of Romania is increasingly evident , constituting a serious problem for the environment and the society .',
  'Wind erosion is a primary cause of desertification as well as being a serious ecological problem in arid and semi-arid areas across the world .',
  'Gully erosion is a serious environmental problem worldwide , causing soil loss , land degradation , silting up of reservoirs and even catastrophic flooding .',
  'Gully erosion is considered as a severe environmental problem in many areas of the world which causes huge damages to agricultural lands and infrastructures ( i.e. roads , buildings , and bridges ) ; however , gully erosion modeling and prediction with high accuracy are still difficult due to the complex interactions of various factors .',
  'Soil erosion and both its on-site and off-site impacts are increasingly seen as a serious environmental problem across the world .',
  'Soil water erosion is a serious problem , especially in agricultural lands .',
  'Land degradation is a serious problem in tropical mountainous areas .',
  'Soil erosion caused by wind is a serious environmental problem that results in land degradation and threatens sustainable development .',
  'Soil desertification has become a serious problem that endangered sustainable development in the ecotone .',
  'Soil erosion is a serious environmental problem .',
  'Overgrazing is a severe problem in several regions in Northwestern China and has caused serious land degradation .',
  'Soil erosion is a serious problem in areas with expanding construction , agricultural production , and improper storm water management .',
  'Ground subsidence is not a severe problem at Wairakei but may prove to be one at the nearby Broadlands field .',
  'Water-induced erosion of iron tailings is a serious problem affecting ecological restoration , but , little is known about how the occurrence of erosion on tailings slopes and types of reclaimed substrates that are beneficial to reducing slope erosion .',
  'Due to the fragility of the natural environment and overexploitation of land by the local people , desertification is becoming a serious problem in the valleys .',
  'Rocky desertification induced by soil loss is a serious ecological problem in karst mountain areas .'],
 'land': ['Soil erosion is a serious environmental problem in Guizhou Province , which is located in the centre of the karst areas of southwestern China .',
  'Rangeland degradation has been identified as a serious concern in alpine regions of western China on the Qinghai-Tibetan plateau ( QTP ) .',
  'Soil degradation through erosion and desertification reduces soil productivity , and is a serious problem in agricultural production of China .',
  'Soil compaction is a serious global problem , and is a major cause of inadequate rooting and poor yield in crops around the world .',
  'Land degradation by water and wind erosion is a serious problem worldwide .',
  'Road embankments erosion is a serious problem in Spain .',
  'Soil erosion has become a serious problem in recent decades due to unhalted trends of unsustainable land use practices .',
  'Soil erosion is a severe problem for many developing regions that lack adequate infrastructure to combat the problem .',
  'Soil erosion has become a serious ecological problem in many catchments .',
  'Erosion of denuded steep rocky slopes causes increasing losses of nitrogen and phosphorus , which is a severe problem in rocky slope protection .',
  'Development and land use change lead to accelerated soil erosion as a serious environmental problem in river catchments in Iran .',
  'Such erosion has become a serious problem in China .',
  'The risk of the desertification of a part of Romania is increasingly evident , constituting a serious problem for the environment and the society .',
  'Wind erosion is a primary cause of desertification as well as being a serious ecological problem in arid and semi-arid areas across the world .',
  'Gully erosion is a serious environmental problem worldwide , causing soil loss , land degradation , silting up of reservoirs and even catastrophic flooding .',
  'Gully erosion is considered as a severe environmental problem in many areas of the world which causes huge damages to agricultural lands and infrastructures ( i.e. roads , buildings , and bridges ) ; however , gully erosion modeling and prediction with high accuracy are still difficult due to the complex interactions of various factors .',
  'Soil erosion and both its on-site and off-site impacts are increasingly seen as a serious environmental problem across the world .',
  'Soil water erosion is a serious problem , especially in agricultural lands .',
  'Land degradation is a serious problem in tropical mountainous areas .',
  'Soil erosion caused by wind is a serious environmental problem that results in land degradation and threatens sustainable development .',
  'Soil desertification has become a serious problem that endangered sustainable development in the ecotone .',
  'Soil erosion is a serious environmental problem .',
  'Overgrazing is a severe problem in several regions in Northwestern China and has caused serious land degradation .',
  'Soil erosion is a serious problem in areas with expanding construction , agricultural production , and improper storm water management .',
  'Ground subsidence is not a severe problem at Wairakei but may prove to be one at the nearby Broadlands field .',
  'Water-induced erosion of iron tailings is a serious problem affecting ecological restoration , but , little is known about how the occurrence of erosion on tailings slopes and types of reclaimed substrates that are beneficial to reducing slope erosion .',
  'Due to the fragility of the natural environment and overexploitation of land by the local people , desertification is becoming a serious problem in the valleys .',
  'Rocky desertification induced by soil loss is a serious ecological problem in karst mountain areas .'],
 'desertification': ['Soil erosion is a serious environmental problem in Guizhou Province , which is located in the centre of the karst areas of southwestern China .',
  'Rangeland degradation has been identified as a serious concern in alpine regions of western China on the Qinghai-Tibetan plateau ( QTP ) .',
  'Soil degradation through erosion and desertification reduces soil productivity , and is a serious problem in agricultural production of China .',
  'Soil compaction is a serious global problem , and is a major cause of inadequate rooting and poor yield in crops around the world .',
  'Land degradation by water and wind erosion is a serious problem worldwide .',
  'Road embankments erosion is a serious problem in Spain .',
  'Soil erosion has become a serious problem in recent decades due to unhalted trends of unsustainable land use practices .',
  'Soil erosion is a severe problem for many developing regions that lack adequate infrastructure to combat the problem .',
  'Soil erosion has become a serious ecological problem in many catchments .',
  'Erosion of denuded steep rocky slopes causes increasing losses of nitrogen and phosphorus , which is a severe problem in rocky slope protection .',
  'Development and land use change lead to accelerated soil erosion as a serious environmental problem in river catchments in Iran .',
  'Such erosion has become a serious problem in China .',
  'The risk of the desertification of a part of Romania is increasingly evident , constituting a serious problem for the environment and the society .',
  'Wind erosion is a primary cause of desertification as well as being a serious ecological problem in arid and semi-arid areas across the world .',
  'Gully erosion is a serious environmental problem worldwide , causing soil loss , land degradation , silting up of reservoirs and even catastrophic flooding .',
  'Gully erosion is considered as a severe environmental problem in many areas of the world which causes huge damages to agricultural lands and infrastructures ( i.e. roads , buildings , and bridges ) ; however , gully erosion modeling and prediction with high accuracy are still difficult due to the complex interactions of various factors .',
  'Soil erosion and both its on-site and off-site impacts are increasingly seen as a serious environmental problem across the world .',
  'Soil water erosion is a serious problem , especially in agricultural lands .',
  'Land degradation is a serious problem in tropical mountainous areas .',
  'Soil erosion caused by wind is a serious environmental problem that results in land degradation and threatens sustainable development .',
  'Soil desertification has become a serious problem that endangered sustainable development in the ecotone .',
  'Soil erosion is a serious environmental problem .',
  'Overgrazing is a severe problem in several regions in Northwestern China and has caused serious land degradation .',
  'Soil erosion is a serious problem in areas with expanding construction , agricultural production , and improper storm water management .',
  'Ground subsidence is not a severe problem at Wairakei but may prove to be one at the nearby Broadlands field .',
  'Water-induced erosion of iron tailings is a serious problem affecting ecological restoration , but , little is known about how the occurrence of erosion on tailings slopes and types of reclaimed substrates that are beneficial to reducing slope erosion .',
  'Due to the fragility of the natural environment and overexploitation of land by the local people , desertification is becoming a serious problem in the valleys .',
  'Rocky desertification induced by soil loss is a serious ecological problem in karst mountain areas .'],
 'bleeding': ['Gastroesophageal variceal bleeding is a serious and difficult problem in the long-term management of biliary atresia ( BA ) .',
  'In the absence of a rapidly fatal primary disease , portal hypertension is not a threatening problem and may be controlled with minimal mortality by appropriate surgical management .',
  'Gastrointestinal ( GI ) tract bleeding of unknown origin is a vexing clinical problem .',
  'PVT represents a serious clinical concern in cirrhotic patients and in those with specific local or systemic risk factors .',
  'Portal vein gas is an ominous radiological sign , which indicates a serious gastrointestinal problem in the majority of patients .',
  'Esophageal hemorrage due to variceal bleeding in cirrhotic patients represents a serious problem for the physician in charge , especially in this country where liver transplants are inexistent ; and also , it is a drama for the patient and its familly .',
  'Background Acute upper gastrointestinal bleeding is a serious medical problem in cirrhotic patients .',
  'Hemorrhage is a frequent complication owing to delayed megakaryocyte engraftment and thrombocytopenia during the early period and is a serious problem in patients with GVHD of the gut .',
  'Hemorrhage of the upper gastrointestinal tract ( UGI ) remains a serious clinical problem .',
  'Undiagnosed chronic/recurrent gastrointestinal bleeding , as defined , is a severe problem to those afflicted , both physically and psychologically as well as socioeconomically .',
  'Bleeding from varicose veins ( VV ) of the esophagus remains a serious therapeutic problem to date .',
  'Severe and intractable gastrointestinal bleeding caused by angiodysplasia is a debilitating problem for up to 20 % of patients with von Willebrand disease ( VWD ) .',
  'Diarrhea was more frequent after TVP ( 13.4 % ) than after HSV ( 1.4 % ) ; although the difference was significant ( p less than 0.025 ) , this complaint did not present a serious clinical problem .',
  'Bleeding from esophageal varices is a serious medical problem because of the risk of recurrent bleeding and high mortality rate ( 17 - 54 % ) .',
  'Acute upper gastrointestinal bleeding is a severe clinical problem with high mortality .',
  'Gastrointestinal haemorrhage ( GI ) is a serious condition that presents both diagnostic as well as therapeutic challenges .',
  'Despite major advances in diagnosis , prevention , and treatment , nonvariceal upper gastrointestinal bleeding still is a serious problem in clinical practice .',
  'Despite the diminishing need for surgical intervention and mortality rates for non-variceal upper gastrointestinal bleeding , as is the case in other European countries , non-variceal upper gastrointestinal bleeding remains a serious problem .',
  'Gastrointestinal bleeding ( GIB ) is a life-threatening problem that requires a multidisciplinary approach for successful treatment .',
  'GV bleedings represent a serious clinical problem compared with esophageal varices due to their location .',
  'Upper gastrointestinal haemorrhage is a severe problem in patients in surgical intensive care units .',
  'Bleeding from esophageal or gastric varices represents a life-threatening event for cirrhotic patients and provides management challenges for the ICU team .',
  'Upper gastrointestinal hemorrhage is a serious health problem with mortality rates that have remained unchanged for the last years in spite of improvements in management .',
  'Acute gastric variceal bleeding ( GVB ) is a catastrophic problem and accounts for one of the major causes of death in cirrhotic patients .',
  'Although most commonly performed portal decompressive procedures control bleeding effectively , postoperative morbidity and mortality remains a serious problem in these patients .'],
 'variceal': ['Gastroesophageal variceal bleeding is a serious and difficult problem in the long-term management of biliary atresia ( BA ) .',
  'In the absence of a rapidly fatal primary disease , portal hypertension is not a threatening problem and may be controlled with minimal mortality by appropriate surgical management .',
  'Gastrointestinal ( GI ) tract bleeding of unknown origin is a vexing clinical problem .',
  'PVT represents a serious clinical concern in cirrhotic patients and in those with specific local or systemic risk factors .',
  'Portal vein gas is an ominous radiological sign , which indicates a serious gastrointestinal problem in the majority of patients .',
  'Esophageal hemorrage due to variceal bleeding in cirrhotic patients represents a serious problem for the physician in charge , especially in this country where liver transplants are inexistent ; and also , it is a drama for the patient and its familly .',
  'Background Acute upper gastrointestinal bleeding is a serious medical problem in cirrhotic patients .',
  'Hemorrhage is a frequent complication owing to delayed megakaryocyte engraftment and thrombocytopenia during the early period and is a serious problem in patients with GVHD of the gut .',
  'Hemorrhage of the upper gastrointestinal tract ( UGI ) remains a serious clinical problem .',
  'Undiagnosed chronic/recurrent gastrointestinal bleeding , as defined , is a severe problem to those afflicted , both physically and psychologically as well as socioeconomically .',
  'Bleeding from varicose veins ( VV ) of the esophagus remains a serious therapeutic problem to date .',
  'Severe and intractable gastrointestinal bleeding caused by angiodysplasia is a debilitating problem for up to 20 % of patients with von Willebrand disease ( VWD ) .',
  'Diarrhea was more frequent after TVP ( 13.4 % ) than after HSV ( 1.4 % ) ; although the difference was significant ( p less than 0.025 ) , this complaint did not present a serious clinical problem .',
  'Bleeding from esophageal varices is a serious medical problem because of the risk of recurrent bleeding and high mortality rate ( 17 - 54 % ) .',
  'Acute upper gastrointestinal bleeding is a severe clinical problem with high mortality .',
  'Gastrointestinal haemorrhage ( GI ) is a serious condition that presents both diagnostic as well as therapeutic challenges .',
  'Despite major advances in diagnosis , prevention , and treatment , nonvariceal upper gastrointestinal bleeding still is a serious problem in clinical practice .',
  'Despite the diminishing need for surgical intervention and mortality rates for non-variceal upper gastrointestinal bleeding , as is the case in other European countries , non-variceal upper gastrointestinal bleeding remains a serious problem .',
  'Gastrointestinal bleeding ( GIB ) is a life-threatening problem that requires a multidisciplinary approach for successful treatment .',
  'GV bleedings represent a serious clinical problem compared with esophageal varices due to their location .',
  'Upper gastrointestinal haemorrhage is a severe problem in patients in surgical intensive care units .',
  'Bleeding from esophageal or gastric varices represents a life-threatening event for cirrhotic patients and provides management challenges for the ICU team .',
  'Upper gastrointestinal hemorrhage is a serious health problem with mortality rates that have remained unchanged for the last years in spite of improvements in management .',
  'Acute gastric variceal bleeding ( GVB ) is a catastrophic problem and accounts for one of the major causes of death in cirrhotic patients .',
  'Although most commonly performed portal decompressive procedures control bleeding effectively , postoperative morbidity and mortality remains a serious problem in these patients .'],
 'cirrhotic': ['Gastroesophageal variceal bleeding is a serious and difficult problem in the long-term management of biliary atresia ( BA ) .',
  'In the absence of a rapidly fatal primary disease , portal hypertension is not a threatening problem and may be controlled with minimal mortality by appropriate surgical management .',
  'Gastrointestinal ( GI ) tract bleeding of unknown origin is a vexing clinical problem .',
  'PVT represents a serious clinical concern in cirrhotic patients and in those with specific local or systemic risk factors .',
  'Portal vein gas is an ominous radiological sign , which indicates a serious gastrointestinal problem in the majority of patients .',
  'Esophageal hemorrage due to variceal bleeding in cirrhotic patients represents a serious problem for the physician in charge , especially in this country where liver transplants are inexistent ; and also , it is a drama for the patient and its familly .',
  'Background Acute upper gastrointestinal bleeding is a serious medical problem in cirrhotic patients .',
  'Hemorrhage is a frequent complication owing to delayed megakaryocyte engraftment and thrombocytopenia during the early period and is a serious problem in patients with GVHD of the gut .',
  'Hemorrhage of the upper gastrointestinal tract ( UGI ) remains a serious clinical problem .',
  'Undiagnosed chronic/recurrent gastrointestinal bleeding , as defined , is a severe problem to those afflicted , both physically and psychologically as well as socioeconomically .',
  'Bleeding from varicose veins ( VV ) of the esophagus remains a serious therapeutic problem to date .',
  'Severe and intractable gastrointestinal bleeding caused by angiodysplasia is a debilitating problem for up to 20 % of patients with von Willebrand disease ( VWD ) .',
  'Diarrhea was more frequent after TVP ( 13.4 % ) than after HSV ( 1.4 % ) ; although the difference was significant ( p less than 0.025 ) , this complaint did not present a serious clinical problem .',
  'Bleeding from esophageal varices is a serious medical problem because of the risk of recurrent bleeding and high mortality rate ( 17 - 54 % ) .',
  'Acute upper gastrointestinal bleeding is a severe clinical problem with high mortality .',
  'Gastrointestinal haemorrhage ( GI ) is a serious condition that presents both diagnostic as well as therapeutic challenges .',
  'Despite major advances in diagnosis , prevention , and treatment , nonvariceal upper gastrointestinal bleeding still is a serious problem in clinical practice .',
  'Despite the diminishing need for surgical intervention and mortality rates for non-variceal upper gastrointestinal bleeding , as is the case in other European countries , non-variceal upper gastrointestinal bleeding remains a serious problem .',
  'Gastrointestinal bleeding ( GIB ) is a life-threatening problem that requires a multidisciplinary approach for successful treatment .',
  'GV bleedings represent a serious clinical problem compared with esophageal varices due to their location .',
  'Upper gastrointestinal haemorrhage is a severe problem in patients in surgical intensive care units .',
  'Bleeding from esophageal or gastric varices represents a life-threatening event for cirrhotic patients and provides management challenges for the ICU team .',
  'Upper gastrointestinal hemorrhage is a serious health problem with mortality rates that have remained unchanged for the last years in spite of improvements in management .',
  'Acute gastric variceal bleeding ( GVB ) is a catastrophic problem and accounts for one of the major causes of death in cirrhotic patients .',
  'Although most commonly performed portal decompressive procedures control bleeding effectively , postoperative morbidity and mortality remains a serious problem in these patients .'],
 'varices': ['Gastroesophageal variceal bleeding is a serious and difficult problem in the long-term management of biliary atresia ( BA ) .',
  'In the absence of a rapidly fatal primary disease , portal hypertension is not a threatening problem and may be controlled with minimal mortality by appropriate surgical management .',
  'Gastrointestinal ( GI ) tract bleeding of unknown origin is a vexing clinical problem .',
  'PVT represents a serious clinical concern in cirrhotic patients and in those with specific local or systemic risk factors .',
  'Portal vein gas is an ominous radiological sign , which indicates a serious gastrointestinal problem in the majority of patients .',
  'Esophageal hemorrage due to variceal bleeding in cirrhotic patients represents a serious problem for the physician in charge , especially in this country where liver transplants are inexistent ; and also , it is a drama for the patient and its familly .',
  'Background Acute upper gastrointestinal bleeding is a serious medical problem in cirrhotic patients .',
  'Hemorrhage is a frequent complication owing to delayed megakaryocyte engraftment and thrombocytopenia during the early period and is a serious problem in patients with GVHD of the gut .',
  'Hemorrhage of the upper gastrointestinal tract ( UGI ) remains a serious clinical problem .',
  'Undiagnosed chronic/recurrent gastrointestinal bleeding , as defined , is a severe problem to those afflicted , both physically and psychologically as well as socioeconomically .',
  'Bleeding from varicose veins ( VV ) of the esophagus remains a serious therapeutic problem to date .',
  'Severe and intractable gastrointestinal bleeding caused by angiodysplasia is a debilitating problem for up to 20 % of patients with von Willebrand disease ( VWD ) .',
  'Diarrhea was more frequent after TVP ( 13.4 % ) than after HSV ( 1.4 % ) ; although the difference was significant ( p less than 0.025 ) , this complaint did not present a serious clinical problem .',
  'Bleeding from esophageal varices is a serious medical problem because of the risk of recurrent bleeding and high mortality rate ( 17 - 54 % ) .',
  'Acute upper gastrointestinal bleeding is a severe clinical problem with high mortality .',
  'Gastrointestinal haemorrhage ( GI ) is a serious condition that presents both diagnostic as well as therapeutic challenges .',
  'Despite major advances in diagnosis , prevention , and treatment , nonvariceal upper gastrointestinal bleeding still is a serious problem in clinical practice .',
  'Despite the diminishing need for surgical intervention and mortality rates for non-variceal upper gastrointestinal bleeding , as is the case in other European countries , non-variceal upper gastrointestinal bleeding remains a serious problem .',
  'Gastrointestinal bleeding ( GIB ) is a life-threatening problem that requires a multidisciplinary approach for successful treatment .',
  'GV bleedings represent a serious clinical problem compared with esophageal varices due to their location .',
  'Upper gastrointestinal haemorrhage is a severe problem in patients in surgical intensive care units .',
  'Bleeding from esophageal or gastric varices represents a life-threatening event for cirrhotic patients and provides management challenges for the ICU team .',
  'Upper gastrointestinal hemorrhage is a serious health problem with mortality rates that have remained unchanged for the last years in spite of improvements in management .',
  'Acute gastric variceal bleeding ( GVB ) is a catastrophic problem and accounts for one of the major causes of death in cirrhotic patients .',
  'Although most commonly performed portal decompressive procedures control bleeding effectively , postoperative morbidity and mortality remains a serious problem in these patients .'],
 'carbapenemase': ['The emergence and rapid spread of carbapenemase-producing Enterobacterales represents a serious public health concern .',
  'We detected and reported the first Japanese case of KPC-2 carbapenemase-producing Klebsiella pneumoniae , of which infection will be a serious problem in the near future in Japan .',
  'The emergence of carbapenem resistant Escherichia coli represents a serious public health concern .',
  'The Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae has become a serious problem because the species is wide ranging and there are few treatment options .',
  'Carbapenem-resistant organism ( CRO ) colonization is a serious problem that increases the risk of infection and contributes to dissemination of antimicrobial resistance in healthcare-associated environments .',
  'Carbapenem resistant Enterobacteriaceae ( CRE ) has become a serious public health problem .',
  'The emergence and spread of carbapenemase-producing Gram-negative bacteria represents a serious public health concern .',
  'This Gram-negative bacterium species has become a serious concern due to its dramatic increase in the levels of multiple antibiotic resistances , particularly to carbapenems .',
  'Infections caused by carbapenem-resistant enterobacteria ( CRE ) are classified as a serious problem .',
  'Carbapenem-resistant Gram-negative pathogens have progressively disseminated to different countries worldwide , presenting a serious public health concern .',
  'The increasing incidence of carbapenemase-producing K. pneumoniae strains ( CP-Kps ) in the last decade has become a serious global healthcare problem .',
  'The emergence and spread of Carbapenem-resistant Escherichia coli ( CREC ) is becoming a serious problem in Chinese hospitals , however , the data on this is scarce .',
  'The spread of plasmids carrying carbapenemase genes resulting in fulminant antimicrobial resistance is a severe concern .',
  'The increasing spread of carbapenem resistance is a serious global public health concern that negatively affects human and animal health .',
  'Within the last decade , human infections caused by enterobacteria which produce the Klebsiella pneumoniae carbapenemase ( KPC ) became a serious therapeutic and epidemiological problem worldwide .',
  'Carbapenem-resistant Enterobacteriaceae infections are a serious health care problem , because of the high mortality .',
  'Multidrug resistant bacteria are a serious worldwide problem , especially carbapenem-resistant',
  'Rapid dissemination of carbapenemase-producing Enterobacteriaceae is a serious concern in patient care and is a problem that has emerged in western Europe .',
  'The development of colistin resistance in carbapenem-resistant strains poses a serious public health problem .',
  'Infections with Carbapenem-Resistant Gram-Negative Bacteria are a Serious Problem Among Critically Ill Children : A Single-Centre Retrospective Study .',
  'The transmission of hospital-acquired Carbapenem-resistant Enterobacteriaceae ( CRE ) is a serious and growing concern in hospitals worldwide .',
  'Carbapenem-resistant Klebsiella pneumoniae ( CRKP ) spread and infections in patients with haematological malignancies are a serious concern especially in endemic areas .',
  'KPC-producing Klebsiella pneumoniae ( KPC-Kp ) represent a serious problem worldwide .',
  'The emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management .',
  'The dissemination of carbapenemase-producing Enterobacteriaceae is currently considered a serious clinical problem due to the failure in the treatment of infections produced by them .',
  'Carbapenem-resistant Klebsiella pneumoniae ( CRKP ) infection is a serious problem in hospitals worldwide , posing a particular risk to immunocompromised patients .',
  'Carbapenemase-producing Enterobacteriaceae ( CPE ) are a serious public health concern and represent a major threat to immunocompromised hosts , including solid organ ( SOT ) and stem cell transplant ( HSCT ) recipients .',
  'The spread of carbapenemase-producing Klebsiella pneumoniae ( CPKP ) worldwide is a serious problem .',
  'The outbreak of carbapenem-resistant Klebsiella pneumoniae is a serious public health problem , especially in the neonatal intensive care unit (NICU).Fifteen K. pneumoniae strains were isolated from 7 neonates during June 3 to 28 , 2017 in an NICU .'],
 'microplastics': ['Microplastics ( MPs ) have become a severe concern in marine environment worldwide .',
  'In recent years , microplastics in oceans have become a serious environmental problem and the focus of attention .',
  'The occurrence and accumulation of microplastics in wildlife and humans have become a serious global scale concern over the last decade .',
  'Increased pollution by plastics has become a serious global environmental problem , but the concerns for human health have been raised after reported presence of microplastics ( MPs ) and nanoplastics ( NPs ) in food and beverages .',
  'In recent decades , microplastic ( MP ) pollution has become a severe problem in aquatic environments .',
  'Micro/nanoplastics are ubiquitous in the environment and cause pollution of the aquatic ecosystem , in particular , which is a serious concern worldwide .',
  'The large proportion of the waste and resistance to degradation means micro- and nanoplastics have become a serious global environmental problem , but there are few studies on their potential toxicity for human health .',
  'As an emerging environmental pollutant , microplastics ( MPs ) are increasingly viewed as a serious health concern to terrestrial and aquatic ecosystems .',
  'Microplastic ( 0.001 - 5 \xa0 mm ) is a serious problem for the environment and is globally distributed .',
  'These results indicate that microplastic accumulation on shorelines in the northern Gulf of Mexico may be a serious concern , and suggest that exposure to inputs from the Gulf is an important determinant of microplastic abundance .',
  'Microplastic pollution ( plastics with particle sizes<5 mm ) has become a serious problem .',
  'The abundant presence and extensive use of polystyrene microplastics ( PSMPs ) has recently become a serious environmental concern , as impact of exposure to these substances on human health remains unknown .'],
 'microplastic': ['Microplastics ( MPs ) have become a severe concern in marine environment worldwide .',
  'In recent years , microplastics in oceans have become a serious environmental problem and the focus of attention .',
  'The occurrence and accumulation of microplastics in wildlife and humans have become a serious global scale concern over the last decade .',
  'Increased pollution by plastics has become a serious global environmental problem , but the concerns for human health have been raised after reported presence of microplastics ( MPs ) and nanoplastics ( NPs ) in food and beverages .',
  'In recent decades , microplastic ( MP ) pollution has become a severe problem in aquatic environments .',
  'Micro/nanoplastics are ubiquitous in the environment and cause pollution of the aquatic ecosystem , in particular , which is a serious concern worldwide .',
  'The large proportion of the waste and resistance to degradation means micro- and nanoplastics have become a serious global environmental problem , but there are few studies on their potential toxicity for human health .',
  'As an emerging environmental pollutant , microplastics ( MPs ) are increasingly viewed as a serious health concern to terrestrial and aquatic ecosystems .',
  'Microplastic ( 0.001 - 5 \xa0 mm ) is a serious problem for the environment and is globally distributed .',
  'These results indicate that microplastic accumulation on shorelines in the northern Gulf of Mexico may be a serious concern , and suggest that exposure to inputs from the Gulf is an important determinant of microplastic abundance .',
  'Microplastic pollution ( plastics with particle sizes<5 mm ) has become a serious problem .',
  'The abundant presence and extensive use of polystyrene microplastics ( PSMPs ) has recently become a serious environmental concern , as impact of exposure to these substances on human health remains unknown .'],
 'nanoplastics': ['Microplastics ( MPs ) have become a severe concern in marine environment worldwide .',
  'In recent years , microplastics in oceans have become a serious environmental problem and the focus of attention .',
  'The occurrence and accumulation of microplastics in wildlife and humans have become a serious global scale concern over the last decade .',
  'Increased pollution by plastics has become a serious global environmental problem , but the concerns for human health have been raised after reported presence of microplastics ( MPs ) and nanoplastics ( NPs ) in food and beverages .',
  'In recent decades , microplastic ( MP ) pollution has become a severe problem in aquatic environments .',
  'Micro/nanoplastics are ubiquitous in the environment and cause pollution of the aquatic ecosystem , in particular , which is a serious concern worldwide .',
  'The large proportion of the waste and resistance to degradation means micro- and nanoplastics have become a serious global environmental problem , but there are few studies on their potential toxicity for human health .',
  'As an emerging environmental pollutant , microplastics ( MPs ) are increasingly viewed as a serious health concern to terrestrial and aquatic ecosystems .',
  'Microplastic ( 0.001 - 5 \xa0 mm ) is a serious problem for the environment and is globally distributed .',
  'These results indicate that microplastic accumulation on shorelines in the northern Gulf of Mexico may be a serious concern , and suggest that exposure to inputs from the Gulf is an important determinant of microplastic abundance .',
  'Microplastic pollution ( plastics with particle sizes<5 mm ) has become a serious problem .',
  'The abundant presence and extensive use of polystyrene microplastics ( PSMPs ) has recently become a serious environmental concern , as impact of exposure to these substances on human health remains unknown .'],
 'rituximab': ['Emergence of pan neuraminidase inhibitor (NAI)-resistant variants constitutes a serious clinical concern .',
  'However , TKI resistance remains a serious problem for patient prognosis .',
  'However , acquired resistance to this drug has become a serious problem in the treatment of brain tumor patients .',
  'Of note , rituximab resistance has become a severe and urgent problem in the rituximab era .',
  'Drug resistance is becoming a serious problem that leads to the failure of standard treatments , which is generally developed because of genetic mutations of certain molecules .',
  'However , the emergence of mutants resistant or cross-resistant to nucleoside/nucleotide analogues remains a serious problem .',
  'Target therapy has been one of the important strategies in new drug discovery and the resulting drug resistance has also been a serious problem for concern .',
  'Emergence of resistant mutations in drug targets represents a serious problem in the targeted chemotherapy .',
  'High prevalence of important resistant phenotypes is of a serious concern .',
  'Drug resistance to nucleoside analogs is a serious problem worldwide .'],
 'nucleoside': ['Emergence of pan neuraminidase inhibitor (NAI)-resistant variants constitutes a serious clinical concern .',
  'However , TKI resistance remains a serious problem for patient prognosis .',
  'However , acquired resistance to this drug has become a serious problem in the treatment of brain tumor patients .',
  'Of note , rituximab resistance has become a severe and urgent problem in the rituximab era .',
  'Drug resistance is becoming a serious problem that leads to the failure of standard treatments , which is generally developed because of genetic mutations of certain molecules .',
  'However , the emergence of mutants resistant or cross-resistant to nucleoside/nucleotide analogues remains a serious problem .',
  'Target therapy has been one of the important strategies in new drug discovery and the resulting drug resistance has also been a serious problem for concern .',
  'Emergence of resistant mutations in drug targets represents a serious problem in the targeted chemotherapy .',
  'High prevalence of important resistant phenotypes is of a serious concern .',
  'Drug resistance to nucleoside analogs is a serious problem worldwide .'],
 'mutations': ['Emergence of pan neuraminidase inhibitor (NAI)-resistant variants constitutes a serious clinical concern .',
  'However , TKI resistance remains a serious problem for patient prognosis .',
  'However , acquired resistance to this drug has become a serious problem in the treatment of brain tumor patients .',
  'Of note , rituximab resistance has become a severe and urgent problem in the rituximab era .',
  'Drug resistance is becoming a serious problem that leads to the failure of standard treatments , which is generally developed because of genetic mutations of certain molecules .',
  'However , the emergence of mutants resistant or cross-resistant to nucleoside/nucleotide analogues remains a serious problem .',
  'Target therapy has been one of the important strategies in new drug discovery and the resulting drug resistance has also been a serious problem for concern .',
  'Emergence of resistant mutations in drug targets represents a serious problem in the targeted chemotherapy .',
  'High prevalence of important resistant phenotypes is of a serious concern .',
  'Drug resistance to nucleoside analogs is a serious problem worldwide .'],
 'neuraminidase': ['Emergence of pan neuraminidase inhibitor (NAI)-resistant variants constitutes a serious clinical concern .',
  'However , TKI resistance remains a serious problem for patient prognosis .',
  'However , acquired resistance to this drug has become a serious problem in the treatment of brain tumor patients .',
  'Of note , rituximab resistance has become a severe and urgent problem in the rituximab era .',
  'Drug resistance is becoming a serious problem that leads to the failure of standard treatments , which is generally developed because of genetic mutations of certain molecules .',
  'However , the emergence of mutants resistant or cross-resistant to nucleoside/nucleotide analogues remains a serious problem .',
  'Target therapy has been one of the important strategies in new drug discovery and the resulting drug resistance has also been a serious problem for concern .',
  'Emergence of resistant mutations in drug targets represents a serious problem in the targeted chemotherapy .',
  'High prevalence of important resistant phenotypes is of a serious concern .',
  'Drug resistance to nucleoside analogs is a serious problem worldwide .'],
 'nucleotide': ['Emergence of pan neuraminidase inhibitor (NAI)-resistant variants constitutes a serious clinical concern .',
  'However , TKI resistance remains a serious problem for patient prognosis .',
  'However , acquired resistance to this drug has become a serious problem in the treatment of brain tumor patients .',
  'Of note , rituximab resistance has become a severe and urgent problem in the rituximab era .',
  'Drug resistance is becoming a serious problem that leads to the failure of standard treatments , which is generally developed because of genetic mutations of certain molecules .',
  'However , the emergence of mutants resistant or cross-resistant to nucleoside/nucleotide analogues remains a serious problem .',
  'Target therapy has been one of the important strategies in new drug discovery and the resulting drug resistance has also been a serious problem for concern .',
  'Emergence of resistant mutations in drug targets represents a serious problem in the targeted chemotherapy .',
  'High prevalence of important resistant phenotypes is of a serious concern .',
  'Drug resistance to nucleoside analogs is a serious problem worldwide .'],
 'organophosphorus': ['Deliberate self-poisoning by ingesting pesticides is a serious health problem among farmers , especially in low- and middle-income countries .',
  'Organophosphorus agents ( OPA ) represent a serious concern to public safety as nerve agents and pesticides .',
  'Organophosphate/phosphonate ( OPP ) compounds represent a serious concern to public safety as nerve agents and pesticides .',
  'Increase in acute intoxication signs/symptoms and decrease in PChE indicate a serious public health problem among farmers who use organophosphate pesticides .',
  'Acute pesticide poisoning has long been a serious problem as a method of suicide worldwide .',
  'Intentional self-poisoning with pesticides is a serious problem in many developing countries .',
  'The poisoning by psychoactive drugs is increasinging in the recent years and organophosphates poisoning seems to be still a serious problem in such an agricultural area .',
  'Organophosphate pesticides are used extensively worldwide , and poisoning by these agents , particularly in developing nations , is a serious public health problem .',
  'Organophosphorus compounds have been widely employed to the development of warfare nerve agents and pesticides , resulting in a huge number of people intoxicated annually , being a serious problem of public health .',
  'Pesticide and rodenticide poisonings , whether intentional or unintentional , pose a serious threat to populations , and the availability of a banned rodenticide such as tetramethylenedisulfotetramine , with its associated morbidity and lethality , is a serious public health concern .',
  'Although methodological problems constitute a major limitation in interpretation of the results , the literature indicates that parasuicide is a serious public health problem .',
  'The inactivation of acetylcholinesterase ( AChE ) by organophosphorus agent ( OP ) compounds is a serious problem regardless of how the individual was exposed .',
  'Exposure to organophosphorus ( OP ) pesticides represents a severe health issue in developing countries , while OP intoxication with the more lethal military nerve agents is not only of military concern but also a terrorist threat .',
  'Exposure to toxic organophosphorus pesticides ( OPP ) represents a serious problem in the public healthcare sector and might be forced in terroristic attacks .',
  'Organophosphate ( OP ) intoxication remains a serious worldwide health concern , and many patients with acute OP intoxication have also consumed alcohol .',
  'Organophosphorus pesticides have largely been used worldwide , and poisoning by these agents , particularly in developing countries , is a serious health problem .'],
 'organophosphate': ['Deliberate self-poisoning by ingesting pesticides is a serious health problem among farmers , especially in low- and middle-income countries .',
  'Organophosphorus agents ( OPA ) represent a serious concern to public safety as nerve agents and pesticides .',
  'Organophosphate/phosphonate ( OPP ) compounds represent a serious concern to public safety as nerve agents and pesticides .',
  'Increase in acute intoxication signs/symptoms and decrease in PChE indicate a serious public health problem among farmers who use organophosphate pesticides .',
  'Acute pesticide poisoning has long been a serious problem as a method of suicide worldwide .',
  'Intentional self-poisoning with pesticides is a serious problem in many developing countries .',
  'The poisoning by psychoactive drugs is increasinging in the recent years and organophosphates poisoning seems to be still a serious problem in such an agricultural area .',
  'Organophosphate pesticides are used extensively worldwide , and poisoning by these agents , particularly in developing nations , is a serious public health problem .',
  'Organophosphorus compounds have been widely employed to the development of warfare nerve agents and pesticides , resulting in a huge number of people intoxicated annually , being a serious problem of public health .',
  'Pesticide and rodenticide poisonings , whether intentional or unintentional , pose a serious threat to populations , and the availability of a banned rodenticide such as tetramethylenedisulfotetramine , with its associated morbidity and lethality , is a serious public health concern .',
  'Although methodological problems constitute a major limitation in interpretation of the results , the literature indicates that parasuicide is a serious public health problem .',
  'The inactivation of acetylcholinesterase ( AChE ) by organophosphorus agent ( OP ) compounds is a serious problem regardless of how the individual was exposed .',
  'Exposure to organophosphorus ( OP ) pesticides represents a severe health issue in developing countries , while OP intoxication with the more lethal military nerve agents is not only of military concern but also a terrorist threat .',
  'Exposure to toxic organophosphorus pesticides ( OPP ) represents a serious problem in the public healthcare sector and might be forced in terroristic attacks .',
  'Organophosphate ( OP ) intoxication remains a serious worldwide health concern , and many patients with acute OP intoxication have also consumed alcohol .',
  'Organophosphorus pesticides have largely been used worldwide , and poisoning by these agents , particularly in developing countries , is a serious health problem .'],
 'rodenticide': ['Deliberate self-poisoning by ingesting pesticides is a serious health problem among farmers , especially in low- and middle-income countries .',
  'Organophosphorus agents ( OPA ) represent a serious concern to public safety as nerve agents and pesticides .',
  'Organophosphate/phosphonate ( OPP ) compounds represent a serious concern to public safety as nerve agents and pesticides .',
  'Increase in acute intoxication signs/symptoms and decrease in PChE indicate a serious public health problem among farmers who use organophosphate pesticides .',
  'Acute pesticide poisoning has long been a serious problem as a method of suicide worldwide .',
  'Intentional self-poisoning with pesticides is a serious problem in many developing countries .',
  'The poisoning by psychoactive drugs is increasinging in the recent years and organophosphates poisoning seems to be still a serious problem in such an agricultural area .',
  'Organophosphate pesticides are used extensively worldwide , and poisoning by these agents , particularly in developing nations , is a serious public health problem .',
  'Organophosphorus compounds have been widely employed to the development of warfare nerve agents and pesticides , resulting in a huge number of people intoxicated annually , being a serious problem of public health .',
  'Pesticide and rodenticide poisonings , whether intentional or unintentional , pose a serious threat to populations , and the availability of a banned rodenticide such as tetramethylenedisulfotetramine , with its associated morbidity and lethality , is a serious public health concern .',
  'Although methodological problems constitute a major limitation in interpretation of the results , the literature indicates that parasuicide is a serious public health problem .',
  'The inactivation of acetylcholinesterase ( AChE ) by organophosphorus agent ( OP ) compounds is a serious problem regardless of how the individual was exposed .',
  'Exposure to organophosphorus ( OP ) pesticides represents a severe health issue in developing countries , while OP intoxication with the more lethal military nerve agents is not only of military concern but also a terrorist threat .',
  'Exposure to toxic organophosphorus pesticides ( OPP ) represents a serious problem in the public healthcare sector and might be forced in terroristic attacks .',
  'Organophosphate ( OP ) intoxication remains a serious worldwide health concern , and many patients with acute OP intoxication have also consumed alcohol .',
  'Organophosphorus pesticides have largely been used worldwide , and poisoning by these agents , particularly in developing countries , is a serious health problem .'],
 'encephalitis': ['Japanese encephalitis is a devastating disease that causes a frequently fatal encephalitis and is a major health problem throughout much of Asia .',
  'Mumps is an acute and self-limiting disease characterized by parotitis , however in some cases it leads to aseptic meningitis , deafness , encephalitis and orchitis , which is a serious health concern .',
  'Japanese encephalitis remains a serious health concern in Asian countries and has sporadically affected pediatric travelers .',
  'Japanese encephalitis ( JE ) is a serious public health concern with a high mortality rate in many Asian countries .',
  'Japanese encephalitis ( JE ) , caused by a mosquito-borne virus JE virus ( JEV ) , is a serious health problem in West Bengal , India .',
  'Encephalitis caused by MVE virus remains a serious problem with no improvement in clinical outcomes in the last 25 years .',
  'Japanese encephalitis is a serious public health problem with significant mortality in children and old people .',
  'Japanese encephalitis ( JE ) is a serious public health concern in most of Asia .',
  'Japanese encephalitis ( JE ) is a serious health problem in the southwestern region of Nepal .',
  'Acute encephalitis syndrome ( AES ) is a serious public health problem , caused mainly by viruses .',
  'Japanese encephalitis virus ( JEV ) has been a serious public health problem in Bellary district since 1981 .',
  'Encephalitis can cause a severe public health problem .'],
 'japanese': ['Japanese encephalitis is a devastating disease that causes a frequently fatal encephalitis and is a major health problem throughout much of Asia .',
  'Mumps is an acute and self-limiting disease characterized by parotitis , however in some cases it leads to aseptic meningitis , deafness , encephalitis and orchitis , which is a serious health concern .',
  'Japanese encephalitis remains a serious health concern in Asian countries and has sporadically affected pediatric travelers .',
  'Japanese encephalitis ( JE ) is a serious public health concern with a high mortality rate in many Asian countries .',
  'Japanese encephalitis ( JE ) , caused by a mosquito-borne virus JE virus ( JEV ) , is a serious health problem in West Bengal , India .',
  'Encephalitis caused by MVE virus remains a serious problem with no improvement in clinical outcomes in the last 25 years .',
  'Japanese encephalitis is a serious public health problem with significant mortality in children and old people .',
  'Japanese encephalitis ( JE ) is a serious public health concern in most of Asia .',
  'Japanese encephalitis ( JE ) is a serious health problem in the southwestern region of Nepal .',
  'Acute encephalitis syndrome ( AES ) is a serious public health problem , caused mainly by viruses .',
  'Japanese encephalitis virus ( JEV ) has been a serious public health problem in Bellary district since 1981 .',
  'Encephalitis can cause a severe public health problem .'],
 'orchitis': ['Japanese encephalitis is a devastating disease that causes a frequently fatal encephalitis and is a major health problem throughout much of Asia .',
  'Mumps is an acute and self-limiting disease characterized by parotitis , however in some cases it leads to aseptic meningitis , deafness , encephalitis and orchitis , which is a serious health concern .',
  'Japanese encephalitis remains a serious health concern in Asian countries and has sporadically affected pediatric travelers .',
  'Japanese encephalitis ( JE ) is a serious public health concern with a high mortality rate in many Asian countries .',
  'Japanese encephalitis ( JE ) , caused by a mosquito-borne virus JE virus ( JEV ) , is a serious health problem in West Bengal , India .',
  'Encephalitis caused by MVE virus remains a serious problem with no improvement in clinical outcomes in the last 25 years .',
  'Japanese encephalitis is a serious public health problem with significant mortality in children and old people .',
  'Japanese encephalitis ( JE ) is a serious public health concern in most of Asia .',
  'Japanese encephalitis ( JE ) is a serious health problem in the southwestern region of Nepal .',
  'Acute encephalitis syndrome ( AES ) is a serious public health problem , caused mainly by viruses .',
  'Japanese encephalitis virus ( JEV ) has been a serious public health problem in Bellary district since 1981 .',
  'Encephalitis can cause a severe public health problem .'],
 'leg': ['The cutaneous ulcer in a patient with a history of international travel poses a vexing diagnostic dilemma for the clinician .',
  'Chronic , nonhealing , cutaneous ulcers are a serious clinical problem .',
  'Chronic ulceration as a complication of arteriosclerotic disease , venous congestion or diabetes mellitus is still a serious clinical problem , resulting in immobilization , extended hospitalization and cost-intensive treatment .',
  'The urgency treatment of a life-threatening bleeding for Cameron ulcers remains a very challenging problem as no univocal and standardized recommendation has been described in literature since now .',
  'The lower extremity vascular ulcers currently represent a major public health problem , particularly because of different situations : the chronic nature of the injury , a poor response to treatment , recurrence rates , high absenteeism , poor training in some cases of the health staff that treats , etc . Lower extremity ulcers mean a serious personal , family , health and social problem , with a significant expenditure of human and material resources .',
  'Healing of ulcers is a serious problem , but preventing recurrence is the greater challenge .',
  'Lower limb ulcers are a serious medical and socioeconomic problem throughout the world .',
  "Venous crural ulcer is a serious medical problem indeed , which is connected with patients ' suffering and long term treatment generating high cost .",
  'Wound pain is a serious problem for elderly patients suffering from chronic leg ulcers , and it may lead to reduced wound healing rates and reduced quality of life .',
  'Stress induced gastric ulcer is a serious health problem in diabetic patients .',
  'Varicose ulcers ( UV ) are a serious health problem which produce tremendous pain for those who suffer from them ; furthermore , they consume a large amount of health care system resources .',
  'Leg ulcers are a serious problem for those affected by them , and health care providers need to be more informed about the effect of chronic health problems on elderly persons .',
  'Pain is a serious problem for patients with leg ulcers .'],
 'aeruginosa': ['Notorious for its antibiotic multiresistance , P. aeruginosa is increasingly recognized as a serious problem in hospitalized patients .',
  'Multi-drug resistance among Pseudomonas aeruginosa ( P. aeruginosa ) clinical isolates is increasing and becoming a serious problem for public health authorities worldwide .',
  'Pseudomonas aeruginosa is an increasingly prevalent pathogen that has become a serious health concern due to an increasing incidence of multidrug-resistant ( MDR ) hospital-acquired infections .',
  'Infections with Pseudomonas aeruginosa are a severe problem for hospitalized patients and for patients suffering from cystic fibrosis .',
  'As colonizers of medical-device surfaces , Pseudomonas aeruginosa strains present a serious source of infection and are of major concern .',
  'In many centers , Pseudomonas cepacia has emerged as a serious problem in patients with cystic fibrosis .',
  'Infection caused by drug-resistant P. aeruginosa is important to identify as it poses a therapeutic problem and is also a serious concern for infection control management .',
  'Increase of multiple drug resistant Pseudomonas aeruginosa ( MDRP ) is becoming a serious problem in the clinical setting .',
  'Chronic pulmonary infections with Pseudomonas aeruginosa remain a serious problem in patients with cystic fibrosis .',
  'The emergence of multidrug-resistant Pseudomonas aeruginosa has become a serious problem in medical settings .',
  'The infection caused by Pseudomonas aeruginosa is a serious concern in human health .',
  'Pseudomonas aeruginosa is an opportunistic bacterial pathogen that forms a serious problem for immunocompromised patients and also the leading cause of mortality in cystic fibrosis .',
  'Pseudomonas aeruginosa ( P. aeruginosa ) is a menacing opportunistic , nosocomial pathogen ; become a growing concern as conventional antimicrobial therapy is now futile against it .',
  'Acute lung infection due to Pseudomonas aeruginosa ( P. aeruginosa ) is a serious problem , especially in patients with structural lung conditions or immune compromised hosts , leading to an overwhelming threat with a high risk of morbidity and mortality .',
  'Antimicrobial resistance in Pseudomonas aeruginosa is a serious clinical problem .',
  'Intrauterine infection due to the pseudomonads poses a serious problem that has not been previously recognized .',
  'Pulmonary infections with Pseudomonas aeruginosa are a serious clinical problem and are often lethal .',
  'Prevalence of ESBLs among P. aeruginosa has been increased in recent years , demonstrate a serious health problem especially in burn units worldwide .',
  'The co-production of plasmid-mediated AmpC along with chromosomal Pseudomonas-derived cephalosporinases thus remain a serious clinical concern owing to high resistance spectrum towards antibiotics .',
  'Colonization of the respiratory tract with Pseudomonas aeruginosa is a serious problem in cystic fibrosis and seriously ill hospitalized patients .',
  'Pseudomonas aeruginosa is one of the most common causes of nosocomial infections , and its multi-drug resistance has been a serious problem worldwide .',
  'P. aeruginosa multi-resistance is a serious problem in the treatment of patients with chronic osteomyelitis .',
  'The emergence of Pseudomonas aeruginosa strains resistant to carbapenems , fluoroquinolones and amikacin , which were defined as multidrug-resistant ( MDR ) strains , is a serious problem in Japan .',
  'In Japan , MDR P. aeruginosa is becoming a serious problem in the clinical setting .',
  'Pseudomonas aeruginosa ( PA ) bloodstream infection ( BSI ) is a common complication in patients with acute leukemia ( AL ) , and the prevalence of antibiotic-resistant strains poses a serious problem .',
  'Among adults with cystic fibrosis , compliance can be a serious problem that minimizes the benefits of good medical care .',
  'Pseudomonas aeruginosa chronic lung infections are the leading cause of mortality in cystic fibrosis patients , a serious problem which is notably due to the numerous P. \xa0 aeruginosa virulence factors , to its ability to form biofilms and to resist the effects of most antibiotics .',
  'Drug-resistant strains of Pseudomonas are a serious health problem , so this family of antibiotics may have important therapeutic applications .',
  'Serious infection due to strains of Pseudomonas aeruginosa that exhibit resistance to all common antipseudomonal antimicrobials increasingly is a serious problem .',
  'Pseudomonas aeruginosa biofilm-associated infections are a serious medical problem , and new compounds and therapies acting through novel mechanisms are much needed .',
  'Pseudomonas aeruginosa is a Gram negative , opportunistic biofilm forming pathogenic bacterium which is developing as a serious problem worldwide .',
  "The emergence of multidrug-resistant ( MDR ) Pseudomonas aeruginosa isolates producing IMP-type metallo-β-lactamases ( MBLs ) and aminoglycoside 6'-N-acetyltransferase [ AAC(6')-Iae ] has become a serious problem in medical settings in Japan .",
  'The emergence of colistin-resistant Pseudomonas aeruginosa is becoming a serious concern worldwide .',
  'P. aeruginosa continues to be a serious problem worldwide as a cause of respiratory tract infections in selected populations .',
  'Pseudomonas aeruginosa is an important opportunistic pathogen that has become a serious problem due to increased rates of antibiotic resistance .',
  'Extremely drug-resistant Pseudomonas \xa0 aeruginosa strains causing severe infections have become a serious concern across the world .',
  'A vexing problem in cystic fibrosis ( CF ) pathogenesis has been to explain the high prevalence of Pseudomonas aeruginosa biofilms in CF airways .',
  'In the past decade , multidrug-resistant Pseudomonas aeruginosa ( MDRP ) infection has become a serious clinical problem , due to the limitation of drug choices to fight against the bacteria .'],
 'pseudomonas': ['Notorious for its antibiotic multiresistance , P. aeruginosa is increasingly recognized as a serious problem in hospitalized patients .',
  'Multi-drug resistance among Pseudomonas aeruginosa ( P. aeruginosa ) clinical isolates is increasing and becoming a serious problem for public health authorities worldwide .',
  'Pseudomonas aeruginosa is an increasingly prevalent pathogen that has become a serious health concern due to an increasing incidence of multidrug-resistant ( MDR ) hospital-acquired infections .',
  'Infections with Pseudomonas aeruginosa are a severe problem for hospitalized patients and for patients suffering from cystic fibrosis .',
  'As colonizers of medical-device surfaces , Pseudomonas aeruginosa strains present a serious source of infection and are of major concern .',
  'In many centers , Pseudomonas cepacia has emerged as a serious problem in patients with cystic fibrosis .',
  'Infection caused by drug-resistant P. aeruginosa is important to identify as it poses a therapeutic problem and is also a serious concern for infection control management .',
  'Increase of multiple drug resistant Pseudomonas aeruginosa ( MDRP ) is becoming a serious problem in the clinical setting .',
  'Chronic pulmonary infections with Pseudomonas aeruginosa remain a serious problem in patients with cystic fibrosis .',
  'The emergence of multidrug-resistant Pseudomonas aeruginosa has become a serious problem in medical settings .',
  'The infection caused by Pseudomonas aeruginosa is a serious concern in human health .',
  'Pseudomonas aeruginosa is an opportunistic bacterial pathogen that forms a serious problem for immunocompromised patients and also the leading cause of mortality in cystic fibrosis .',
  'Pseudomonas aeruginosa ( P. aeruginosa ) is a menacing opportunistic , nosocomial pathogen ; become a growing concern as conventional antimicrobial therapy is now futile against it .',
  'Acute lung infection due to Pseudomonas aeruginosa ( P. aeruginosa ) is a serious problem , especially in patients with structural lung conditions or immune compromised hosts , leading to an overwhelming threat with a high risk of morbidity and mortality .',
  'Antimicrobial resistance in Pseudomonas aeruginosa is a serious clinical problem .',
  'Intrauterine infection due to the pseudomonads poses a serious problem that has not been previously recognized .',
  'Pulmonary infections with Pseudomonas aeruginosa are a serious clinical problem and are often lethal .',
  'Prevalence of ESBLs among P. aeruginosa has been increased in recent years , demonstrate a serious health problem especially in burn units worldwide .',
  'The co-production of plasmid-mediated AmpC along with chromosomal Pseudomonas-derived cephalosporinases thus remain a serious clinical concern owing to high resistance spectrum towards antibiotics .',
  'Colonization of the respiratory tract with Pseudomonas aeruginosa is a serious problem in cystic fibrosis and seriously ill hospitalized patients .',
  'Pseudomonas aeruginosa is one of the most common causes of nosocomial infections , and its multi-drug resistance has been a serious problem worldwide .',
  'P. aeruginosa multi-resistance is a serious problem in the treatment of patients with chronic osteomyelitis .',
  'The emergence of Pseudomonas aeruginosa strains resistant to carbapenems , fluoroquinolones and amikacin , which were defined as multidrug-resistant ( MDR ) strains , is a serious problem in Japan .',
  'In Japan , MDR P. aeruginosa is becoming a serious problem in the clinical setting .',
  'Pseudomonas aeruginosa ( PA ) bloodstream infection ( BSI ) is a common complication in patients with acute leukemia ( AL ) , and the prevalence of antibiotic-resistant strains poses a serious problem .',
  'Among adults with cystic fibrosis , compliance can be a serious problem that minimizes the benefits of good medical care .',
  'Pseudomonas aeruginosa chronic lung infections are the leading cause of mortality in cystic fibrosis patients , a serious problem which is notably due to the numerous P. \xa0 aeruginosa virulence factors , to its ability to form biofilms and to resist the effects of most antibiotics .',
  'Drug-resistant strains of Pseudomonas are a serious health problem , so this family of antibiotics may have important therapeutic applications .',
  'Serious infection due to strains of Pseudomonas aeruginosa that exhibit resistance to all common antipseudomonal antimicrobials increasingly is a serious problem .',
  'Pseudomonas aeruginosa biofilm-associated infections are a serious medical problem , and new compounds and therapies acting through novel mechanisms are much needed .',
  'Pseudomonas aeruginosa is a Gram negative , opportunistic biofilm forming pathogenic bacterium which is developing as a serious problem worldwide .',
  "The emergence of multidrug-resistant ( MDR ) Pseudomonas aeruginosa isolates producing IMP-type metallo-β-lactamases ( MBLs ) and aminoglycoside 6'-N-acetyltransferase [ AAC(6')-Iae ] has become a serious problem in medical settings in Japan .",
  'The emergence of colistin-resistant Pseudomonas aeruginosa is becoming a serious concern worldwide .',
  'P. aeruginosa continues to be a serious problem worldwide as a cause of respiratory tract infections in selected populations .',
  'Pseudomonas aeruginosa is an important opportunistic pathogen that has become a serious problem due to increased rates of antibiotic resistance .',
  'Extremely drug-resistant Pseudomonas \xa0 aeruginosa strains causing severe infections have become a serious concern across the world .',
  'A vexing problem in cystic fibrosis ( CF ) pathogenesis has been to explain the high prevalence of Pseudomonas aeruginosa biofilms in CF airways .',
  'In the past decade , multidrug-resistant Pseudomonas aeruginosa ( MDRP ) infection has become a serious clinical problem , due to the limitation of drug choices to fight against the bacteria .'],
 'meningococcal': ['Meningococcal disease is a serious public health problem with a case fatality of about 10 % .',
  'Invasive infections caused by Neisseria meningitidis continue to be a serious clinical problem for therapy , epidemiology , and potential prophylaxis .',
  'Neisseria meningitidis infections represent a serious health problem that can lead to invasive meningococcal disease ( IMD ) , a life-threatening condition associated with significant morbidity and mortality .',
  'Meningococcal disease ( MD ) is a medical emergency and a serious public health problem .',
  'Meningococcal disease remains a serious public health problem worldwide .',
  'Although invasive meningococcal disease ( IMD ) is relatively rare in travelers since the advent of quadrivalent meningococcal vaccines , it remains a serious concern because of its rapid progression , poor prognosis and outcomes , associated treatment delays , and the potential to precipitate outbreaks .',
  'Meningococcal disease , presenting primarily as septicaemia and meningitis , continues to be a devastating problem around the world .',
  'Invasive meningococcal disease a serious problem for public health .',
  'Meningococcal disease continues to be a serious public health concern , being associated with high morbidity and mortality rates in many countries from Latin America .',
  'Invasive infections caused by Neisseria meningitidis are a serious public health problem worldwide and have a heavy economic impact .',
  'Meningococcal colonization , or carriage , can progress to invasive meningococcal disease , a serious public health concern , with rapid progression of disease and severe consequences if left untreated .',
  'Invasive meningococcal disease ( IMD ) remains a serious public health concern due to a sustained high case fatality rate and morbidity in survivors .',
  'Invasive meningococcal disease ( IMD ) remains a serious public health problem .',
  'Invasive meningococcal disease ( IMD ) is a severe disease caused by various Neisseria meningitidis serogroups that represents a serious public health problem worldwide .',
  'Meningococcal disease has been a serious problem in Norway for nearly a decade .',
  'Meningococcal disease has been a serious public health problem in the city of Rio de Janeiro , with high attack rates among younger children , high case fatality rates , and predominance of serogroup B. In December 1994 the second vaccination drive against B and C meningococcal disease was performed with the objective of protecting children ages 6 months to 13 years .',
  'Meningococcal disease is a serious problem in adolescents , including high school students .',
  'Invasive meningococcal disease due to serogroups A , C , Y and W-135 is a serious , vaccine-preventable , worldwide public-health problem .',
  'Neisseria meningitidis group C is an encapsulated bacterium that causes several diseases and is associated with high mortality rates , thereby constituting a serious public health problem .',
  'Meningococcal disease is still a serious public health problem in many countries .',
  'The emergence of such strains might represent a serious problem affecting the empirical antibiotic treatment of meningococcal disease .',
  'In addition to frequent epidemics of group A meningococcal disease , endemic bacterial meningitis due mostly to Neisseria meningitidis , pneumococcus , and Haemophilus influenzae type b is a serious problem in sub-Saharan Africa .',
  'The threat from invasive meningococcal disease ( IMD ) remains a serious source of concern despite the licensure and availability of vaccines .',
  'Although the incidence of meningococcal disease is low in the United States , outbreaks remain a serious public health concern .',
  'Serogroup B meningococcal ( MenB ) disease remains a serious public health problem for which a cross-protective vaccine effective against a wide range of MenB isolates has not been available .',
  'Invasive meningococcal diseases have become in the Czech Republic since 1993 a serious epidemiological and clinical problem due to a clonus which was not present previously : Neisseria meningitidis C:2a : P1.2,P1.5 , ET-15/37 .',
  'Serogroup B meningococcal disease remains a serious problem in many countries and no effective vaccine is currently available .'],
 'meningitidis': ['Meningococcal disease is a serious public health problem with a case fatality of about 10 % .',
  'Invasive infections caused by Neisseria meningitidis continue to be a serious clinical problem for therapy , epidemiology , and potential prophylaxis .',
  'Neisseria meningitidis infections represent a serious health problem that can lead to invasive meningococcal disease ( IMD ) , a life-threatening condition associated with significant morbidity and mortality .',
  'Meningococcal disease ( MD ) is a medical emergency and a serious public health problem .',
  'Meningococcal disease remains a serious public health problem worldwide .',
  'Although invasive meningococcal disease ( IMD ) is relatively rare in travelers since the advent of quadrivalent meningococcal vaccines , it remains a serious concern because of its rapid progression , poor prognosis and outcomes , associated treatment delays , and the potential to precipitate outbreaks .',
  'Meningococcal disease , presenting primarily as septicaemia and meningitis , continues to be a devastating problem around the world .',
  'Invasive meningococcal disease a serious problem for public health .',
  'Meningococcal disease continues to be a serious public health concern , being associated with high morbidity and mortality rates in many countries from Latin America .',
  'Invasive infections caused by Neisseria meningitidis are a serious public health problem worldwide and have a heavy economic impact .',
  'Meningococcal colonization , or carriage , can progress to invasive meningococcal disease , a serious public health concern , with rapid progression of disease and severe consequences if left untreated .',
  'Invasive meningococcal disease ( IMD ) remains a serious public health concern due to a sustained high case fatality rate and morbidity in survivors .',
  'Invasive meningococcal disease ( IMD ) remains a serious public health problem .',
  'Invasive meningococcal disease ( IMD ) is a severe disease caused by various Neisseria meningitidis serogroups that represents a serious public health problem worldwide .',
  'Meningococcal disease has been a serious problem in Norway for nearly a decade .',
  'Meningococcal disease has been a serious public health problem in the city of Rio de Janeiro , with high attack rates among younger children , high case fatality rates , and predominance of serogroup B. In December 1994 the second vaccination drive against B and C meningococcal disease was performed with the objective of protecting children ages 6 months to 13 years .',
  'Meningococcal disease is a serious problem in adolescents , including high school students .',
  'Invasive meningococcal disease due to serogroups A , C , Y and W-135 is a serious , vaccine-preventable , worldwide public-health problem .',
  'Neisseria meningitidis group C is an encapsulated bacterium that causes several diseases and is associated with high mortality rates , thereby constituting a serious public health problem .',
  'Meningococcal disease is still a serious public health problem in many countries .',
  'The emergence of such strains might represent a serious problem affecting the empirical antibiotic treatment of meningococcal disease .',
  'In addition to frequent epidemics of group A meningococcal disease , endemic bacterial meningitis due mostly to Neisseria meningitidis , pneumococcus , and Haemophilus influenzae type b is a serious problem in sub-Saharan Africa .',
  'The threat from invasive meningococcal disease ( IMD ) remains a serious source of concern despite the licensure and availability of vaccines .',
  'Although the incidence of meningococcal disease is low in the United States , outbreaks remain a serious public health concern .',
  'Serogroup B meningococcal ( MenB ) disease remains a serious public health problem for which a cross-protective vaccine effective against a wide range of MenB isolates has not been available .',
  'Invasive meningococcal diseases have become in the Czech Republic since 1993 a serious epidemiological and clinical problem due to a clonus which was not present previously : Neisseria meningitidis C:2a : P1.2,P1.5 , ET-15/37 .',
  'Serogroup B meningococcal disease remains a serious problem in many countries and no effective vaccine is currently available .'],
 'neisseria': ['Meningococcal disease is a serious public health problem with a case fatality of about 10 % .',
  'Invasive infections caused by Neisseria meningitidis continue to be a serious clinical problem for therapy , epidemiology , and potential prophylaxis .',
  'The occurrence of antibiotic resistant Neisseria gonorrhoeae isolates is a serious public health problem in different corners of the globe .',
  'Neisseria meningitidis infections represent a serious health problem that can lead to invasive meningococcal disease ( IMD ) , a life-threatening condition associated with significant morbidity and mortality .',
  'The widespread antimicrobial resistance of Neisseria gonorrhoeae is a serious problem for the treatment and control of gonorrhoea .',
  'Meningococcal disease ( MD ) is a medical emergency and a serious public health problem .',
  'Meningococcal disease remains a serious public health problem worldwide .',
  'Although invasive meningococcal disease ( IMD ) is relatively rare in travelers since the advent of quadrivalent meningococcal vaccines , it remains a serious concern because of its rapid progression , poor prognosis and outcomes , associated treatment delays , and the potential to precipitate outbreaks .',
  'Meningococcal disease , presenting primarily as septicaemia and meningitis , continues to be a devastating problem around the world .',
  'Invasive meningococcal disease a serious problem for public health .',
  'Antimicrobial resistance of Neisseria gonorrhoeae is a serious health problem in China .',
  'Gonorrhea in women : a serious health problem .',
  'Meningococcal disease continues to be a serious public health concern , being associated with high morbidity and mortality rates in many countries from Latin America .',
  'Gonorrhoea is one of the most common sexually transmitted infections ( STIs ) in the world , and is a serious public health problem because of its associated morbidity and complications .',
  'Invasive infections caused by Neisseria meningitidis are a serious public health problem worldwide and have a heavy economic impact .',
  'Multidrug resistance is a serious problem that threatens the effective treatment of the widespread sexually transmitted disease gonorrhea , caused by the Gram-negative bacterium',
  'Meningococcal colonization , or carriage , can progress to invasive meningococcal disease , a serious public health concern , with rapid progression of disease and severe consequences if left untreated .',
  'Invasive meningococcal disease ( IMD ) remains a serious public health concern due to a sustained high case fatality rate and morbidity in survivors .',
  'Invasive meningococcal disease ( IMD ) remains a serious public health problem .',
  'Invasive meningococcal disease ( IMD ) is a severe disease caused by various Neisseria meningitidis serogroups that represents a serious public health problem worldwide .',
  'Meningococcal disease has been a serious problem in Norway for nearly a decade .',
  'Antimicrobial resistance ( AMR ) in Neisseria gonorrhoeae is a serious public health problem , compromising the management and control of gonorrhoea globally .',
  'The antimicrobial resistance of Neisseria gonorrhoeae is a serious problem worldwide .',
  'Emergence of multidrug-resistant ( MDR ) and extensively drug-resistant ( XDR ) Neisseria gonorrhoeae is a serious concern and combination therapy has been recommended to delay the onset of treatment failures .',
  'Neisseria gonorrhoeae ( NG ) infection is a serious public health problem .',
  'Meningococcal disease has been a serious public health problem in the city of Rio de Janeiro , with high attack rates among younger children , high case fatality rates , and predominance of serogroup B. In December 1994 the second vaccination drive against B and C meningococcal disease was performed with the objective of protecting children ages 6 months to 13 years .',
  'Increasing rates of gonococcal ( GC ) infection and antimicrobial resistant ( AMR ) GC , are a serious public health concern for Canada and around the world .',
  'Meningococcal disease is a serious problem in adolescents , including high school students .',
  'Invasive meningococcal disease due to serogroups A , C , Y and W-135 is a serious , vaccine-preventable , worldwide public-health problem .',
  'Neisseria meningitidis group C is an encapsulated bacterium that causes several diseases and is associated with high mortality rates , thereby constituting a serious public health problem .',
  'Meningococcal disease is still a serious public health problem in many countries .',
  'Gonococcal infections are now an uncommon problem in newborns in industrialized countries but remain a serious problem in developing countries due to ongoing high infection rates in pregnant women .',
  'The emergence of such strains might represent a serious problem affecting the empirical antibiotic treatment of meningococcal disease .',
  'In addition to frequent epidemics of group A meningococcal disease , endemic bacterial meningitis due mostly to Neisseria meningitidis , pneumococcus , and Haemophilus influenzae type b is a serious problem in sub-Saharan Africa .',
  'The sexually transmitted disease , gonorrhea , is a serious health problem in developed as well as in developing countries , for which treatment continues to be a challenge .',
  'The threat from invasive meningococcal disease ( IMD ) remains a serious source of concern despite the licensure and availability of vaccines .',
  'However , this has not become a serious problem to date , as large scale evaluation has shown that the quinolones remain highly efficacious for the treatment of gonorrhoea .',
  'Although the incidence of meningococcal disease is low in the United States , outbreaks remain a serious public health concern .',
  'Serogroup B meningococcal ( MenB ) disease remains a serious public health problem for which a cross-protective vaccine effective against a wide range of MenB isolates has not been available .',
  'Invasive meningococcal diseases have become in the Czech Republic since 1993 a serious epidemiological and clinical problem due to a clonus which was not present previously : Neisseria meningitidis C:2a : P1.2,P1.5 , ET-15/37 .',
  'Serogroup B meningococcal disease remains a serious problem in many countries and no effective vaccine is currently available .'],
 'cough': ['Chronic cough can be a troublesome clinical problem .',
  'A high frequency of obliterative bronchiolitis with loss of pulmonary function is still a serious and unsolved problem .',
  'Overall , a chronic cough is not only a serious health problem , but also a social one .',
  'Bronchiolitis is a serious public health problem generating a great demand at the primary care level .',
  'In past 2 decades , nonmedical consumption of cough mixture has become a serious social problem in certain regions of China .',
  'Chronic cough remains a vexing problem for many physicians , including gastroenterologists .',
  'Chronic Bronchitis is a serious and costly health problem .',
  'However , obliterative bronchiolitis remains a serious problem .',
  'Cough remains a serious unmet clinical problem , both as a symptom of a range of other conditions such as asthma , chronic obstructive pulmonary disease , gastroesophageal reflux , and as a problem in its own right in patients with chronic cough of unknown origin .',
  'Chronic cough is a debilitating , often multifactorial problem .',
  'The classical type of bronchiolitis in infancy as the most severe among acute infections of respiratory organs because of its poor prognosis at the very beginning and the long-term sequels is a serious medical problem .',
  'Chronic bronchitis remains as a serious medical problem for many adults and a smaller proportion of children in the United States .',
  'Bronchiectasis remains a serious problem in developing countries .'],
 'bronchiolitis': ['Chronic cough can be a troublesome clinical problem .',
  'A high frequency of obliterative bronchiolitis with loss of pulmonary function is still a serious and unsolved problem .',
  'Overall , a chronic cough is not only a serious health problem , but also a social one .',
  'Bronchiolitis is a serious public health problem generating a great demand at the primary care level .',
  'In past 2 decades , nonmedical consumption of cough mixture has become a serious social problem in certain regions of China .',
  'Chronic cough remains a vexing problem for many physicians , including gastroenterologists .',
  'Chronic Bronchitis is a serious and costly health problem .',
  'However , obliterative bronchiolitis remains a serious problem .',
  'Cough remains a serious unmet clinical problem , both as a symptom of a range of other conditions such as asthma , chronic obstructive pulmonary disease , gastroesophageal reflux , and as a problem in its own right in patients with chronic cough of unknown origin .',
  'Chronic cough is a debilitating , often multifactorial problem .',
  'The classical type of bronchiolitis in infancy as the most severe among acute infections of respiratory organs because of its poor prognosis at the very beginning and the long-term sequels is a serious medical problem .',
  'Chronic bronchitis remains as a serious medical problem for many adults and a smaller proportion of children in the United States .',
  'Bronchiectasis remains a serious problem in developing countries .'],
 'bronchitis': ['Chronic cough can be a troublesome clinical problem .',
  'A high frequency of obliterative bronchiolitis with loss of pulmonary function is still a serious and unsolved problem .',
  'Overall , a chronic cough is not only a serious health problem , but also a social one .',
  'Bronchiolitis is a serious public health problem generating a great demand at the primary care level .',
  'In past 2 decades , nonmedical consumption of cough mixture has become a serious social problem in certain regions of China .',
  'Chronic cough remains a vexing problem for many physicians , including gastroenterologists .',
  'Chronic Bronchitis is a serious and costly health problem .',
  'However , obliterative bronchiolitis remains a serious problem .',
  'Cough remains a serious unmet clinical problem , both as a symptom of a range of other conditions such as asthma , chronic obstructive pulmonary disease , gastroesophageal reflux , and as a problem in its own right in patients with chronic cough of unknown origin .',
  'Chronic cough is a debilitating , often multifactorial problem .',
  'The classical type of bronchiolitis in infancy as the most severe among acute infections of respiratory organs because of its poor prognosis at the very beginning and the long-term sequels is a serious medical problem .',
  'Chronic bronchitis remains as a serious medical problem for many adults and a smaller proportion of children in the United States .',
  'Bronchiectasis remains a serious problem in developing countries .'],
 'gastroenterologists': ['Chronic cough can be a troublesome clinical problem .',
  'A high frequency of obliterative bronchiolitis with loss of pulmonary function is still a serious and unsolved problem .',
  'Overall , a chronic cough is not only a serious health problem , but also a social one .',
  'Bronchiolitis is a serious public health problem generating a great demand at the primary care level .',
  'In past 2 decades , nonmedical consumption of cough mixture has become a serious social problem in certain regions of China .',
  'Chronic cough remains a vexing problem for many physicians , including gastroenterologists .',
  'Chronic Bronchitis is a serious and costly health problem .',
  'However , obliterative bronchiolitis remains a serious problem .',
  'Cough remains a serious unmet clinical problem , both as a symptom of a range of other conditions such as asthma , chronic obstructive pulmonary disease , gastroesophageal reflux , and as a problem in its own right in patients with chronic cough of unknown origin .',
  'Chronic cough is a debilitating , often multifactorial problem .',
  'The classical type of bronchiolitis in infancy as the most severe among acute infections of respiratory organs because of its poor prognosis at the very beginning and the long-term sequels is a serious medical problem .',
  'Chronic bronchitis remains as a serious medical problem for many adults and a smaller proportion of children in the United States .',
  'Bronchiectasis remains a serious problem in developing countries .'],
 'pathogens': ['Waterborne diseases that originated due to pathogen microorganisms are emerging as a serious global health concern .',
  'Microbial contamination has evolved as a life-threatening problem afflicting people due to various diseases caused by pathogenic bacteria in drinking water .',
  'Pathogen contamination of the public drinking water supply in the New York City watersheds is a serious concern .',
  'Exposure to pathogens in recreational or drinking water is a serious public health concern .',
  'Diseases caused by microbial contaminants in drinking water continue to be a serious problem in countries like Mexico .',
  'Giardia and Cryptosporidium species are a serious problem if present in water supplies .',
  'Fecal pollution of water is a serious concern because it is associated with the transmission of pathogens .',
  'Growth of Legionella pneumophila in tap water installations is a serious public health concern .',
  'The opportunistic microorganisms provoke environmental contaminations in health and storage facilities to represent a serious concern to health security .',
  'Elevated numbers of enteric pathogens in the receiving waters following a storm event can be a serious public health concern .',
  'Transmission of pathogenic protozoa and helminths by water is a serious public health problem .',
  'Because of heavy dependence on groundwater for drinking water and other domestic use , microbial contamination of groundwater is a serious problem in the Kathmandu Valley , Nepal .',
  'Contamination of water by fecal matter and potential human enteric pathogens is a serious health concern .',
  'Contamination of tap water by Methylobacterium species has become a serious concern in hospitals .',
  'Exposure to waterborne pathogens in recreational or drinking water is a serious public health concern .',
  'Wastewater irrigation in the Middle East , one of the most water-stressed regions in the world , could be a key factor for socio-economic development , but the microbial contamination of untreated or partially treated wastewater is a serious public health concern .',
  'A serious concern for managers of water resources , pathogens in the urban environment easily enter waters through a number of pathways , including discharge of inadequately treated sewage , stormwater runoff , combined sewer overflows and sanitary sewer overflows .'],
 'microbial': ['Waterborne diseases that originated due to pathogen microorganisms are emerging as a serious global health concern .',
  'Microbial contamination has evolved as a life-threatening problem afflicting people due to various diseases caused by pathogenic bacteria in drinking water .',
  'Pathogen contamination of the public drinking water supply in the New York City watersheds is a serious concern .',
  'Exposure to pathogens in recreational or drinking water is a serious public health concern .',
  'Diseases caused by microbial contaminants in drinking water continue to be a serious problem in countries like Mexico .',
  'Giardia and Cryptosporidium species are a serious problem if present in water supplies .',
  'Fecal pollution of water is a serious concern because it is associated with the transmission of pathogens .',
  'Growth of Legionella pneumophila in tap water installations is a serious public health concern .',
  'The opportunistic microorganisms provoke environmental contaminations in health and storage facilities to represent a serious concern to health security .',
  'Elevated numbers of enteric pathogens in the receiving waters following a storm event can be a serious public health concern .',
  'Transmission of pathogenic protozoa and helminths by water is a serious public health problem .',
  'Because of heavy dependence on groundwater for drinking water and other domestic use , microbial contamination of groundwater is a serious problem in the Kathmandu Valley , Nepal .',
  'Contamination of water by fecal matter and potential human enteric pathogens is a serious health concern .',
  'Contamination of tap water by Methylobacterium species has become a serious concern in hospitals .',
  'Exposure to waterborne pathogens in recreational or drinking water is a serious public health concern .',
  'Wastewater irrigation in the Middle East , one of the most water-stressed regions in the world , could be a key factor for socio-economic development , but the microbial contamination of untreated or partially treated wastewater is a serious public health concern .',
  'A serious concern for managers of water resources , pathogens in the urban environment easily enter waters through a number of pathways , including discharge of inadequately treated sewage , stormwater runoff , combined sewer overflows and sanitary sewer overflows .'],
 'multimorbidity': ['With the general aging of the population they represent a serious and growing public health concern .',
  'Therefore , presenteeism is likely to become a serious public health problem .',
  'Disuse atrophy in the elderly is becoming a serious problem in many developed countries .',
  'In industry this condition presents a serious problem to older workers , to employers and to insurance carriers .',
  'Thus , aging is a serious public health problem .',
  "It is a serious problem facing the elderly in today 's society .",
  'Although current models of care are generally well-suited to providing treatment for individual medical conditions , the emergence of multimorbidity is becoming a serious concern for practitioners and policy researchers , particularly in developing countries .',
  '( 3 ) Results : Multimorbidity was a serious health problem in rural , disease-causing poverty , older-age households , with the prevalence of multimorbidity estimated as 40 % for women and 35.4 % for men .',
  'The dry form of ARMD is becoming a serious problem because of the rise in the number of old individuals .',
  'It is also expected to pose a serious problem in future societies composed of large numbers of elderly people .',
  'In connection with population aging and the huge variety of factors and conditions that can induce this condition , it is becoming a serious and growing problem .',
  'Those diseases constitute a serious health problem within the sickness absenteeism of workers over 40 .',
  'this reflects a serious concern about the staffing of the geriatric service .',
  'With the rising incidence of chronic diseases , and the increase of aging population has led to multimorbidity a serious public health problem .',
  'It is one of the most prevalent CV conditions worldwide in subjects > 65 years , estimated to increase greatly with the aging of the population , becoming a severe socioeconomic problem in the future .',
  'Multimorbidity is increasingly being recognized as a serious public health concern .',
  'The combination of an aging population and a high incidence in geriatric patients constitute a serious potential public health concern .',
  'Due to its course and incidence are a major cause of disability and impaired quality of life for seniors , as well as a serious economic problem in health care .',
  'We conclude that HCAIs are a serious health problem in German nursing home residents .',
  'This condition is becoming a serious problem because of the increasing numbers of the aged population all over the world .'],
 'aspiration': ['Foreign body aspiration is a serious problem that may lead to complications or even death .',
  'Pediatric airway foreign body aspiration is a life-threatening clinical entity in any setting , but it presents unique challenges in resource-limited settings where rigid bronchoscopy is not available .',
  'Foreign body aspiration is a serious health problem in all age groups , and in pregnancy it may cause serious complications for the fetus as well as the pregnant woman .',
  'Gastrointestinal injuries secondary to button battery ingestions in children have emerged as a dangerous and difficult management problem for pediatricians .',
  'Inhaled , swallowed or aspirated foreign body is a serious problem and on occasions can be fatal ( Schloss et al 1983 ) .',
  'Foreign body aspiration continues to be a serious problem in childhood and adolescent period with significant rate of morbidity and rarely mortality .',
  'Foreign body ingestion and aspiration in children has been a serious problem , occasionally resulting in airway obstruction and death .',
  'Foreign body ( FB ) ingestion is a common emergency as well as a major cause of accidental injury and represents a severe public health problem in childhood , especially in infants .',
  'Tracheobronchial foreign body aspiration is a serious medical problem , with clinical manifestations ranging from acute asphyxiation to insidious lung damage , as demonstrated by the three presented cases .',
  'Geophagia , the deliberate ingestion of earth , is a serious clinical problem , particularly for dialysis patients .',
  'Foreign body aspiration ( FBA ) is a serious medical problem , also in dental practice .',
  'Ingestion of foreign body is a serious problem commonly encountered in our clinical practice .',
  'Foreign Body Aspiration ( FBA ) is a serious problem in children and delays in diagnosis and management can be devastating .',
  'AFBs remain a serious health concern , especially non-food objects in older children which have elevated risks .',
  'Foreign body asphyxia is a serious clinical problem with high morbidity and mortality rates .',
  'Management of foreign body aspiration in infancy and childhood . A life-threatening problem .',
  'Foreign body ( FB ) aspiration/inhalation is a serious problem because it is still a cause of death in children , especially among those younger than 4 years .',
  'FB aspiration is a serious problem .',
  'Since aspiration of foreign bodies can be a serious and sometimes fatal problem , early intervention and proper management is vital .',
  'Foreign body aspiration ( FBA ) is a serious medical problem , causing thousands of deaths nationally each year .',
  'Aspiration of foreign bodies is extremely rare in adults , but it may occur during the course of dental treatment and become a serious problem for the patient .'],
 'ingestion': ['Foreign body aspiration is a serious problem that may lead to complications or even death .',
  'Pediatric airway foreign body aspiration is a life-threatening clinical entity in any setting , but it presents unique challenges in resource-limited settings where rigid bronchoscopy is not available .',
  'Foreign body aspiration is a serious health problem in all age groups , and in pregnancy it may cause serious complications for the fetus as well as the pregnant woman .',
  'Gastrointestinal injuries secondary to button battery ingestions in children have emerged as a dangerous and difficult management problem for pediatricians .',
  'Inhaled , swallowed or aspirated foreign body is a serious problem and on occasions can be fatal ( Schloss et al 1983 ) .',
  'Caustic ingestion is a serious medical problem affecting anywhere from 5,000 to 15,000 persons per year .',
  'Foreign body aspiration continues to be a serious problem in childhood and adolescent period with significant rate of morbidity and rarely mortality .',
  'Foreign body ingestion and aspiration in children has been a serious problem , occasionally resulting in airway obstruction and death .',
  "Caustic stenosis is a serious problem in children due to its complicated resolution and implications in important areas like nutrition , as well as the child 's tolerance to the measures taken to correct them .",
  'Foreign body ( FB ) ingestion is a common emergency as well as a major cause of accidental injury and represents a severe public health problem in childhood , especially in infants .',
  'Caustic esophageal burn is a serious problem in pediatric surgery .',
  'Tracheobronchial foreign body aspiration is a serious medical problem , with clinical manifestations ranging from acute asphyxiation to insidious lung damage , as demonstrated by the three presented cases .',
  'Caustic ingestion is a serious medical problem with a variety of clinical presentations and a complicated clinical course .',
  'Geophagia , the deliberate ingestion of earth , is a serious clinical problem , particularly for dialysis patients .',
  'Caustic substance ingestion ( CSI ) is a serious medical problem with potentially devastating short- and long-term consequences .',
  'Foreign body aspiration ( FBA ) is a serious medical problem , also in dental practice .',
  'Ingestion of foreign body is a serious problem commonly encountered in our clinical practice .',
  'The ingestion of caustic substances represents a serious problem , often with devastating consequences on the esophagus and the stomach .',
  'Foreign Body Aspiration ( FBA ) is a serious problem in children and delays in diagnosis and management can be devastating .',
  'AFBs remain a serious health concern , especially non-food objects in older children which have elevated risks .',
  'Corrosive esophageal injury due to accidental ingestion is a serious clinical problem in children particularly in developing countries .',
  'Foreign body asphyxia is a serious clinical problem with high morbidity and mortality rates .',
  'Management of foreign body aspiration in infancy and childhood . A life-threatening problem .',
  'Caustic esophagitis is a serious clinical problem and many agents are currently tried out in many experimental models .',
  'Foreign body ( FB ) aspiration/inhalation is a serious problem because it is still a cause of death in children , especially among those younger than 4 years .',
  'FB aspiration is a serious problem .',
  'The ingestion of caustic substances can represent a serious medical problem in children .',
  'Oesophageal strictures developing after caustic ingestion in children are a serious problem , and several protocols to prevent stricture formation have been proposed .',
  'the ingestion of chemical agents , of caustic nature , represents a serious problem for clinical toxicology .',
  'Since aspiration of foreign bodies can be a serious and sometimes fatal problem , early intervention and proper management is vital .',
  'Foreign body aspiration ( FBA ) is a serious medical problem , causing thousands of deaths nationally each year .',
  'Aspiration of foreign bodies is extremely rare in adults , but it may occur during the course of dental treatment and become a serious problem for the patient .'],
 'porcine': ['The recent outbreaks of atypical or acute PRRS in vaccinated pigs have raised a serious concern about the efficacy of the current vaccines and provided the impetus for developing more effective vaccines .',
  'Porcine respiratory disease complex ( PRDC ) is a serious health problem that mainly affects growing and finishing pigs .',
  'Modified live vaccines ( MLVs ) have been utilized to combat porcine reproductive and respiratory syndrome ( PRRS ) , which raises a serious concern about the MLV-derived PRRS virus ( PRRSV ) isolates .',
  'Porcine reproductive and respiratory syndrome virus ( PRRSV ) has caused tremendous economic losses and continues to be a serious problem to the swine industry worldwide .',
  'Porcine circovirus type 2 ( PCV2 ) , the primary causative agent of porcine circovirus-associated diseases ( PCVADs ) , is a serious economic problem for the swine industry worldwide .',
  'Porcine circovirus type 2 ( PCV2 ) , the causative agent of postweaning multisystemic wasting syndrome ( PMWS ) , is a serious economic problem for the swine industry in China .',
  'The risk of transmission of PRRSV by semen may therefore constitute a serious problem to the Danish pig industry .',
  'Porcine circovirus type 2 ( PCV2 ) is considered to be the primary causative agent of postweaning multisystemic wasting syndrome ( PMWS ) , which has become a serious economic problem for the swine industry worldwide .',
  'Porcine epidemic diarrhea virus ( PEDV ) infection , which causes acute diarrhea and dehydration in suckling piglets , has become a serious problem for the swine industry of China in recent years .',
  'Porcine circovirus type 2 ( PCV2 ) is a causative agent of porcine circovirus-associated disease ( PCVAD ) , which is a serious problem in the swine industry worldwide .',
  'PCVAD may be only a sporadic individual animal diagnosis ; however , PCVAD may also manifest as a severe herd problem accelerated and enhanced by concurrent virus or bacterial infections .',
  'Porcine reproductive and respiratory syndrome virus ( PRRSV ) infection is a severe concern in the porcine industry due to reproduction failure and respiratory symptoms .',
  'Porcine circovirus type 2 ( PCV2 ) , the causative agent of postweaning multisystemic wasting syndrome ( PMWS ) , is a serious economic problem in the swine industry .',
  'Porcine reproductive and respiratory syndrome virus ( PRRSV ) has caused tremendous economic losses and continues to be a serious problem to the swine industry worldwide .',
  'In contrast , in Slovakia , Q fever does not pose a serious public health problem , and the chronic form of infection has not been found either in follow-ups of a Q-fever epidemic connected with goats imported from Bulgaria and other previous Q-fever outbreaks or in a serologic survey .',
  'HEV was widespread in commercial swine population in Eastern and Southern China that raised a serious concern about the safety regarding the consumption of pork products .',
  'Because attenuated Korean LOM strains have been used in animal vaccination in Korea for some time but CSF remains a serious problem , there was a need for a practical approach to differentiating vaccine and field strains .',
  'Porcine epidemic diarrhea virus ( PEDV ) is a major causative agent of fatal diarrhea in piglets and is a serious problem in the hog-raising industry .',
  'Porcine circovirus 2 ( PCV2 ) is a serious problem to the swine industry and can lead to significant negative impacts on profitability of pork production .'],
 'swine': ['The recent outbreaks of atypical or acute PRRS in vaccinated pigs have raised a serious concern about the efficacy of the current vaccines and provided the impetus for developing more effective vaccines .',
  'Porcine respiratory disease complex ( PRDC ) is a serious health problem that mainly affects growing and finishing pigs .',
  'Modified live vaccines ( MLVs ) have been utilized to combat porcine reproductive and respiratory syndrome ( PRRS ) , which raises a serious concern about the MLV-derived PRRS virus ( PRRSV ) isolates .',
  'Porcine reproductive and respiratory syndrome virus ( PRRSV ) has caused tremendous economic losses and continues to be a serious problem to the swine industry worldwide .',
  'Porcine circovirus type 2 ( PCV2 ) , the primary causative agent of porcine circovirus-associated diseases ( PCVADs ) , is a serious economic problem for the swine industry worldwide .',
  'Porcine circovirus type 2 ( PCV2 ) , the causative agent of postweaning multisystemic wasting syndrome ( PMWS ) , is a serious economic problem for the swine industry in China .',
  'The risk of transmission of PRRSV by semen may therefore constitute a serious problem to the Danish pig industry .',
  'Porcine circovirus type 2 ( PCV2 ) is considered to be the primary causative agent of postweaning multisystemic wasting syndrome ( PMWS ) , which has become a serious economic problem for the swine industry worldwide .',
  'Porcine epidemic diarrhea virus ( PEDV ) infection , which causes acute diarrhea and dehydration in suckling piglets , has become a serious problem for the swine industry of China in recent years .',
  'Porcine circovirus type 2 ( PCV2 ) is a causative agent of porcine circovirus-associated disease ( PCVAD ) , which is a serious problem in the swine industry worldwide .',
  'PCVAD may be only a sporadic individual animal diagnosis ; however , PCVAD may also manifest as a severe herd problem accelerated and enhanced by concurrent virus or bacterial infections .',
  'Porcine reproductive and respiratory syndrome virus ( PRRSV ) infection is a severe concern in the porcine industry due to reproduction failure and respiratory symptoms .',
  'Porcine circovirus type 2 ( PCV2 ) , the causative agent of postweaning multisystemic wasting syndrome ( PMWS ) , is a serious economic problem in the swine industry .',
  'Porcine reproductive and respiratory syndrome virus ( PRRSV ) has caused tremendous economic losses and continues to be a serious problem to the swine industry worldwide .',
  'In contrast , in Slovakia , Q fever does not pose a serious public health problem , and the chronic form of infection has not been found either in follow-ups of a Q-fever epidemic connected with goats imported from Bulgaria and other previous Q-fever outbreaks or in a serologic survey .',
  'HEV was widespread in commercial swine population in Eastern and Southern China that raised a serious concern about the safety regarding the consumption of pork products .',
  'Because attenuated Korean LOM strains have been used in animal vaccination in Korea for some time but CSF remains a serious problem , there was a need for a practical approach to differentiating vaccine and field strains .',
  'Porcine epidemic diarrhea virus ( PEDV ) is a major causative agent of fatal diarrhea in piglets and is a serious problem in the hog-raising industry .',
  'Porcine circovirus 2 ( PCV2 ) is a serious problem to the swine industry and can lead to significant negative impacts on profitability of pork production .'],
 'circovirus': ['The recent outbreaks of atypical or acute PRRS in vaccinated pigs have raised a serious concern about the efficacy of the current vaccines and provided the impetus for developing more effective vaccines .',
  'Porcine respiratory disease complex ( PRDC ) is a serious health problem that mainly affects growing and finishing pigs .',
  'Modified live vaccines ( MLVs ) have been utilized to combat porcine reproductive and respiratory syndrome ( PRRS ) , which raises a serious concern about the MLV-derived PRRS virus ( PRRSV ) isolates .',
  'Porcine reproductive and respiratory syndrome virus ( PRRSV ) has caused tremendous economic losses and continues to be a serious problem to the swine industry worldwide .',
  'Porcine circovirus type 2 ( PCV2 ) , the primary causative agent of porcine circovirus-associated diseases ( PCVADs ) , is a serious economic problem for the swine industry worldwide .',
  'Porcine circovirus type 2 ( PCV2 ) , the causative agent of postweaning multisystemic wasting syndrome ( PMWS ) , is a serious economic problem for the swine industry in China .',
  'The risk of transmission of PRRSV by semen may therefore constitute a serious problem to the Danish pig industry .',
  'Porcine circovirus type 2 ( PCV2 ) is considered to be the primary causative agent of postweaning multisystemic wasting syndrome ( PMWS ) , which has become a serious economic problem for the swine industry worldwide .',
  'Porcine epidemic diarrhea virus ( PEDV ) infection , which causes acute diarrhea and dehydration in suckling piglets , has become a serious problem for the swine industry of China in recent years .',
  'Porcine circovirus type 2 ( PCV2 ) is a causative agent of porcine circovirus-associated disease ( PCVAD ) , which is a serious problem in the swine industry worldwide .',
  'PCVAD may be only a sporadic individual animal diagnosis ; however , PCVAD may also manifest as a severe herd problem accelerated and enhanced by concurrent virus or bacterial infections .',
  'Porcine reproductive and respiratory syndrome virus ( PRRSV ) infection is a severe concern in the porcine industry due to reproduction failure and respiratory symptoms .',
  'Porcine circovirus type 2 ( PCV2 ) , the causative agent of postweaning multisystemic wasting syndrome ( PMWS ) , is a serious economic problem in the swine industry .',
  'Porcine reproductive and respiratory syndrome virus ( PRRSV ) has caused tremendous economic losses and continues to be a serious problem to the swine industry worldwide .',
  'In contrast , in Slovakia , Q fever does not pose a serious public health problem , and the chronic form of infection has not been found either in follow-ups of a Q-fever epidemic connected with goats imported from Bulgaria and other previous Q-fever outbreaks or in a serologic survey .',
  'HEV was widespread in commercial swine population in Eastern and Southern China that raised a serious concern about the safety regarding the consumption of pork products .',
  'Because attenuated Korean LOM strains have been used in animal vaccination in Korea for some time but CSF remains a serious problem , there was a need for a practical approach to differentiating vaccine and field strains .',
  'Porcine epidemic diarrhea virus ( PEDV ) is a major causative agent of fatal diarrhea in piglets and is a serious problem in the hog-raising industry .',
  'Porcine circovirus 2 ( PCV2 ) is a serious problem to the swine industry and can lead to significant negative impacts on profitability of pork production .'],
 'pcv2': ['The recent outbreaks of atypical or acute PRRS in vaccinated pigs have raised a serious concern about the efficacy of the current vaccines and provided the impetus for developing more effective vaccines .',
  'Porcine respiratory disease complex ( PRDC ) is a serious health problem that mainly affects growing and finishing pigs .',
  'Modified live vaccines ( MLVs ) have been utilized to combat porcine reproductive and respiratory syndrome ( PRRS ) , which raises a serious concern about the MLV-derived PRRS virus ( PRRSV ) isolates .',
  'Porcine reproductive and respiratory syndrome virus ( PRRSV ) has caused tremendous economic losses and continues to be a serious problem to the swine industry worldwide .',
  'Porcine circovirus type 2 ( PCV2 ) , the primary causative agent of porcine circovirus-associated diseases ( PCVADs ) , is a serious economic problem for the swine industry worldwide .',
  'Porcine circovirus type 2 ( PCV2 ) , the causative agent of postweaning multisystemic wasting syndrome ( PMWS ) , is a serious economic problem for the swine industry in China .',
  'The risk of transmission of PRRSV by semen may therefore constitute a serious problem to the Danish pig industry .',
  'Porcine circovirus type 2 ( PCV2 ) is considered to be the primary causative agent of postweaning multisystemic wasting syndrome ( PMWS ) , which has become a serious economic problem for the swine industry worldwide .',
  'Porcine epidemic diarrhea virus ( PEDV ) infection , which causes acute diarrhea and dehydration in suckling piglets , has become a serious problem for the swine industry of China in recent years .',
  'Porcine circovirus type 2 ( PCV2 ) is a causative agent of porcine circovirus-associated disease ( PCVAD ) , which is a serious problem in the swine industry worldwide .',
  'PCVAD may be only a sporadic individual animal diagnosis ; however , PCVAD may also manifest as a severe herd problem accelerated and enhanced by concurrent virus or bacterial infections .',
  'Porcine reproductive and respiratory syndrome virus ( PRRSV ) infection is a severe concern in the porcine industry due to reproduction failure and respiratory symptoms .',
  'Porcine circovirus type 2 ( PCV2 ) , the causative agent of postweaning multisystemic wasting syndrome ( PMWS ) , is a serious economic problem in the swine industry .',
  'Porcine reproductive and respiratory syndrome virus ( PRRSV ) has caused tremendous economic losses and continues to be a serious problem to the swine industry worldwide .',
  'In contrast , in Slovakia , Q fever does not pose a serious public health problem , and the chronic form of infection has not been found either in follow-ups of a Q-fever epidemic connected with goats imported from Bulgaria and other previous Q-fever outbreaks or in a serologic survey .',
  'HEV was widespread in commercial swine population in Eastern and Southern China that raised a serious concern about the safety regarding the consumption of pork products .',
  'Because attenuated Korean LOM strains have been used in animal vaccination in Korea for some time but CSF remains a serious problem , there was a need for a practical approach to differentiating vaccine and field strains .',
  'Porcine epidemic diarrhea virus ( PEDV ) is a major causative agent of fatal diarrhea in piglets and is a serious problem in the hog-raising industry .',
  'Porcine circovirus 2 ( PCV2 ) is a serious problem to the swine industry and can lead to significant negative impacts on profitability of pork production .'],
 'mercury': ['In the James Bay region of Canada , with the advent of extensive hydroelectric development , methylmercury contamination of fish has become a serious problem , having a direct impact on the Cree way of living .',
  'Mercury pollution is a serious problem in some areas of the southeastern United States .',
  'The contamination of water surfaces by mercury is a dangerous environmental problem due to its toxicity , which leads kidney damage .',
  'The elevated mercury concentrations in marine organisms are a serious concern for human health ; according to the national average fish consumption , the provisional tolerable weekly intake ( PTWI ) of Hg would be easily exceeded by at least 4 to 12 fold .',
  'Mercury contamination in the Gold-Cyanide Process ( GCP ) is a serious health and environmental problem .',
  'Mercury contamination is a serious problem in Chinese cities .',
  "Mercury ( Hg ) loading in Lake Baikal , a UNESCO world heritage site , is growing and poses a serious health concern to the lake 's ecosystem due to the ability of Hg to transform into a toxic form , known as methylmercury ( MeHg ) .",
  'Mercury contamination of soil and water is a serious problem at many sites in the United States and throughout the world .',
  'Environmental contamination caused by mercury is a serious problem worldwide .',
  'Environmental contamination caused by mercury is a serious problem worldwide .',
  'Mercury contamination constitutes a serious health problem .',
  'Mercury vapor poisoning is a serious and potentially fatal problem .',
  'Exposure to inorganic mercury ( Hg ) is a serious problem presenting with a combination of neurological and psychiatric symptoms along with weight loss , pruritus , erythema , arterial hypertension , tachycardia , and renal tubular dysfunction .',
  'Mercury ions , even an ultra-trace amount in water , present a serious environmental concern .',
  'Mercury is a highly toxic heavy metal and the ability of the neurotoxin methylmercury to biomagnify in the food chain is a serious concern for both public and environmental health globally .',
  'Human exposure to mercury is a serious problem of public health in Amazon .',
  'Acute mercury vapour poisoning is a serious , potentially fatal but fortunately rarely encountered problem .',
  'Mercury contamination is a serious environmental problem worldwide .',
  'Contamination of soils with mercury can be a serious problem .',
  'In short , Hg pollution from gold mining around Grande Marsh has permeated the food web , and currently levels in fish represent a serious concern for human health .',
  'Anthropogenic elemental mercury ( Hg(0 ) ) emission is a serious worldwide environmental problem due to the extreme toxicity of the heavy metal to humans , plants and wildlife .',
  'Mercury intoxication is a serious public health problem and a worldwide concern .',
  'Mercury contamination in the water bodies of developing countries is a serious concern due to its toxicity , persistence , and bioaccumulation .',
  'Mercury contamination in fish is a serious public health concern that contrasts with other health benefits of eating fish .',
  'Methylmercury ( MeHg ) exposure is a serious problem of public health , especially in the Amazon .',
  'Conclusion : This study shows that there is a serious problem of mercury contamination in gold mining regions of Antioquia , with significant involvement of the most vulnerable population .',
  'Mercury ( Hg ) contamination is widespread in the Laurentian Great Lakes region and is a serious environmental concern .',
  'Mercury allergy is a serious health problem .'],
 'methylmercury': ['In the James Bay region of Canada , with the advent of extensive hydroelectric development , methylmercury contamination of fish has become a serious problem , having a direct impact on the Cree way of living .',
  'Mercury pollution is a serious problem in some areas of the southeastern United States .',
  'The contamination of water surfaces by mercury is a dangerous environmental problem due to its toxicity , which leads kidney damage .',
  'The elevated mercury concentrations in marine organisms are a serious concern for human health ; according to the national average fish consumption , the provisional tolerable weekly intake ( PTWI ) of Hg would be easily exceeded by at least 4 to 12 fold .',
  'Mercury contamination in the Gold-Cyanide Process ( GCP ) is a serious health and environmental problem .',
  'Mercury contamination is a serious problem in Chinese cities .',
  "Mercury ( Hg ) loading in Lake Baikal , a UNESCO world heritage site , is growing and poses a serious health concern to the lake 's ecosystem due to the ability of Hg to transform into a toxic form , known as methylmercury ( MeHg ) .",
  'Mercury contamination of soil and water is a serious problem at many sites in the United States and throughout the world .',
  'Environmental contamination caused by mercury is a serious problem worldwide .',
  'Environmental contamination caused by mercury is a serious problem worldwide .',
  'Mercury contamination constitutes a serious health problem .',
  'Mercury vapor poisoning is a serious and potentially fatal problem .',
  'Exposure to inorganic mercury ( Hg ) is a serious problem presenting with a combination of neurological and psychiatric symptoms along with weight loss , pruritus , erythema , arterial hypertension , tachycardia , and renal tubular dysfunction .',
  'Mercury ions , even an ultra-trace amount in water , present a serious environmental concern .',
  'Mercury is a highly toxic heavy metal and the ability of the neurotoxin methylmercury to biomagnify in the food chain is a serious concern for both public and environmental health globally .',
  'Human exposure to mercury is a serious problem of public health in Amazon .',
  'Acute mercury vapour poisoning is a serious , potentially fatal but fortunately rarely encountered problem .',
  'Mercury contamination is a serious environmental problem worldwide .',
  'Contamination of soils with mercury can be a serious problem .',
  'In short , Hg pollution from gold mining around Grande Marsh has permeated the food web , and currently levels in fish represent a serious concern for human health .',
  'Anthropogenic elemental mercury ( Hg(0 ) ) emission is a serious worldwide environmental problem due to the extreme toxicity of the heavy metal to humans , plants and wildlife .',
  'Mercury intoxication is a serious public health problem and a worldwide concern .',
  'Mercury contamination in the water bodies of developing countries is a serious concern due to its toxicity , persistence , and bioaccumulation .',
  'Mercury contamination in fish is a serious public health concern that contrasts with other health benefits of eating fish .',
  'Methylmercury ( MeHg ) exposure is a serious problem of public health , especially in the Amazon .',
  'Conclusion : This study shows that there is a serious problem of mercury contamination in gold mining regions of Antioquia , with significant involvement of the most vulnerable population .',
  'Mercury ( Hg ) contamination is widespread in the Laurentian Great Lakes region and is a serious environmental concern .',
  'Mercury allergy is a serious health problem .'],
 'concussion': ['Concussion is currently a serious health problem and can lead to severe brain dysfunction .',
  'Head injury remains a serious public problem , especially in the young population .',
  'Underreporting of concussions is proposed as a serious concern , and concussion understanding and attitudes can impact reporting .',
  'Despite concussion being a serious public health concern and the increasing participation of female athletes in sport , the comparative long-term outcomes of male and female athletes are poorly understood , potentially limiting the scientific understanding and clinical management of these injuries .',
  'Brain concussion is a serious public health concern and is associated with short-term cognitive impairments and behavioral disturbances that typically occur in the absence of significant brain damage .',
  'Concussion is a serious health concern .',
  'Although there has been a significant decrease in the overall rate of injury during the past 25 years , head injury remains a serious safety concern in motor sports and the greatest cause of death .',
  'Repeated concussion is becoming increasingly recognized as a serious public health concern around the world .',
  'Head injury , which annually affects 154 per 100,000 persons in Maryland , is a serious problem requiring attention from the medical community .',
  'Concussions remain a serious public health concern .',
  'Concussions remain a serious public health concern , with approximately 1.6 million to 3 million sport and recreational traumatic and brain injuries occurring every year in the United States .',
  'Brain concussions are a serious public concern and are associated with neuropsychiatric disorders , such as depression .',
  'Concussions in student-athletes are a serious problem .',
  'Sports-related concussion , is a serious neurological concern that many adolescent athletes will face during their athletic careers .',
  'Cranio-cerebral traumatism occupies the first place among the causes of lethal outcomes and invalidism of the population and is a serious social-economic problem .',
  'Concussions are occurring at alarming rates in the United States and have become a serious public health concern .',
  'Underreporting of concussions and concussion-like symptoms in athletes continues to be a serious medical concern and research focus .',
  'Sports-related concussion ( SRC ) is a serious health concern .'],
 'concussions': ['Concussion is currently a serious health problem and can lead to severe brain dysfunction .',
  'Head injury remains a serious public problem , especially in the young population .',
  'Underreporting of concussions is proposed as a serious concern , and concussion understanding and attitudes can impact reporting .',
  'Despite concussion being a serious public health concern and the increasing participation of female athletes in sport , the comparative long-term outcomes of male and female athletes are poorly understood , potentially limiting the scientific understanding and clinical management of these injuries .',
  'Brain concussion is a serious public health concern and is associated with short-term cognitive impairments and behavioral disturbances that typically occur in the absence of significant brain damage .',
  'Concussion is a serious health concern .',
  'Although there has been a significant decrease in the overall rate of injury during the past 25 years , head injury remains a serious safety concern in motor sports and the greatest cause of death .',
  'Repeated concussion is becoming increasingly recognized as a serious public health concern around the world .',
  'Head injury , which annually affects 154 per 100,000 persons in Maryland , is a serious problem requiring attention from the medical community .',
  'Concussions remain a serious public health concern .',
  'Concussions remain a serious public health concern , with approximately 1.6 million to 3 million sport and recreational traumatic and brain injuries occurring every year in the United States .',
  'Brain concussions are a serious public concern and are associated with neuropsychiatric disorders , such as depression .',
  'Concussions in student-athletes are a serious problem .',
  'Sports-related concussion , is a serious neurological concern that many adolescent athletes will face during their athletic careers .',
  'Cranio-cerebral traumatism occupies the first place among the causes of lethal outcomes and invalidism of the population and is a serious social-economic problem .',
  'Concussions are occurring at alarming rates in the United States and have become a serious public health concern .',
  'Underreporting of concussions and concussion-like symptoms in athletes continues to be a serious medical concern and research focus .',
  'Sports-related concussion ( SRC ) is a serious health concern .'],
 'athletes': ['Concussion is currently a serious health problem and can lead to severe brain dysfunction .',
  'Head injury remains a serious public problem , especially in the young population .',
  'Underreporting of concussions is proposed as a serious concern , and concussion understanding and attitudes can impact reporting .',
  'Despite concussion being a serious public health concern and the increasing participation of female athletes in sport , the comparative long-term outcomes of male and female athletes are poorly understood , potentially limiting the scientific understanding and clinical management of these injuries .',
  'Brain concussion is a serious public health concern and is associated with short-term cognitive impairments and behavioral disturbances that typically occur in the absence of significant brain damage .',
  'Concussion is a serious health concern .',
  'Although there has been a significant decrease in the overall rate of injury during the past 25 years , head injury remains a serious safety concern in motor sports and the greatest cause of death .',
  'Repeated concussion is becoming increasingly recognized as a serious public health concern around the world .',
  'Head injury , which annually affects 154 per 100,000 persons in Maryland , is a serious problem requiring attention from the medical community .',
  'Concussions remain a serious public health concern .',
  'Concussions remain a serious public health concern , with approximately 1.6 million to 3 million sport and recreational traumatic and brain injuries occurring every year in the United States .',
  'Brain concussions are a serious public concern and are associated with neuropsychiatric disorders , such as depression .',
  'Concussions in student-athletes are a serious problem .',
  'Sports-related concussion , is a serious neurological concern that many adolescent athletes will face during their athletic careers .',
  'Cranio-cerebral traumatism occupies the first place among the causes of lethal outcomes and invalidism of the population and is a serious social-economic problem .',
  'Concussions are occurring at alarming rates in the United States and have become a serious public health concern .',
  'Underreporting of concussions and concussion-like symptoms in athletes continues to be a serious medical concern and research focus .',
  'Sports-related concussion ( SRC ) is a serious health concern .'],
 'apnea': ['Obstructive sleep apnea is a serious medical problem producing both physical and behavioral derangement .',
  'Obstructive sleep apnea ( OSA ) is a serious and costly public health problem .',
  'Snoring : an annoyance or a serious health problem ( obstructive sleep apnea ) ?',
  'Obstructive sleep apnea is increasingly being recognized as a serious public health problem , and is characterized by repetitive , complete or partial closure of the upper airway during sleep , resulting in sleep fragmentation and oxygen desaturation .',
  'The shortening of the pre-inspiratory activity of the HG in the reserpine model may indicate a serious problem with maintaining the correct diameter of the upper airways in the preparation phase for inspiratory effort and explain the development of obstructive sleep apnea in some PD patients .',
  'Sleep-apnea syndrome is a serious problem in respiratory care .',
  "By the way , doctor . My wife says I snore a lot . I do n't think I have sleep apnea , but I 'm not sure . Is there anything I can do for a serious snoring problem ?",
  'Some current pharmacologic treatments for insomnia cause respiratory depression , a serious safety concern , particularly for individuals with obstructive sleep apnea ( OSA ) .',
  'Obstructive sleep apnea-hypopnea syndrome ( OSAHS ) is a serious social health problem with significant implications on quality of life .',
  'Snoring is common and may be a serious medical problem .',
  'Sleep apnea is a serious public health problem that increases when children and adolescents are overweight or obese .',
  'Obstructive sleep apnoea ( OSA ) is a serious worldwide health problem .',
  'Sleep disturbance is a serious health concern among asthma patients .',
  'Respiratory disorders during sleep are a serious medical , economic and social problem .',
  'Obstructive sleep apnea ( OSA ) is a serious , common , and underdiagnosed disorder that challenges health care resources .'],
 'snoring': ['Obstructive sleep apnea is a serious medical problem producing both physical and behavioral derangement .',
  'Obstructive sleep apnea ( OSA ) is a serious and costly public health problem .',
  'Snoring : an annoyance or a serious health problem ( obstructive sleep apnea ) ?',
  'Obstructive sleep apnea is increasingly being recognized as a serious public health problem , and is characterized by repetitive , complete or partial closure of the upper airway during sleep , resulting in sleep fragmentation and oxygen desaturation .',
  'The shortening of the pre-inspiratory activity of the HG in the reserpine model may indicate a serious problem with maintaining the correct diameter of the upper airways in the preparation phase for inspiratory effort and explain the development of obstructive sleep apnea in some PD patients .',
  'Sleep-apnea syndrome is a serious problem in respiratory care .',
  "By the way , doctor . My wife says I snore a lot . I do n't think I have sleep apnea , but I 'm not sure . Is there anything I can do for a serious snoring problem ?",
  'Some current pharmacologic treatments for insomnia cause respiratory depression , a serious safety concern , particularly for individuals with obstructive sleep apnea ( OSA ) .',
  'Obstructive sleep apnea-hypopnea syndrome ( OSAHS ) is a serious social health problem with significant implications on quality of life .',
  'Snoring is common and may be a serious medical problem .',
  'Sleep apnea is a serious public health problem that increases when children and adolescents are overweight or obese .',
  'Obstructive sleep apnoea ( OSA ) is a serious worldwide health problem .',
  'Sleep disturbance is a serious health concern among asthma patients .',
  'Respiratory disorders during sleep are a serious medical , economic and social problem .',
  'Obstructive sleep apnea ( OSA ) is a serious , common , and underdiagnosed disorder that challenges health care resources .'],
 'inspiratory': ['Obstructive sleep apnea is a serious medical problem producing both physical and behavioral derangement .',
  'Obstructive sleep apnea ( OSA ) is a serious and costly public health problem .',
  'Snoring : an annoyance or a serious health problem ( obstructive sleep apnea ) ?',
  'Obstructive sleep apnea is increasingly being recognized as a serious public health problem , and is characterized by repetitive , complete or partial closure of the upper airway during sleep , resulting in sleep fragmentation and oxygen desaturation .',
  'The shortening of the pre-inspiratory activity of the HG in the reserpine model may indicate a serious problem with maintaining the correct diameter of the upper airways in the preparation phase for inspiratory effort and explain the development of obstructive sleep apnea in some PD patients .',
  'Sleep-apnea syndrome is a serious problem in respiratory care .',
  "By the way , doctor . My wife says I snore a lot . I do n't think I have sleep apnea , but I 'm not sure . Is there anything I can do for a serious snoring problem ?",
  'Some current pharmacologic treatments for insomnia cause respiratory depression , a serious safety concern , particularly for individuals with obstructive sleep apnea ( OSA ) .',
  'Obstructive sleep apnea-hypopnea syndrome ( OSAHS ) is a serious social health problem with significant implications on quality of life .',
  'Snoring is common and may be a serious medical problem .',
  'Sleep apnea is a serious public health problem that increases when children and adolescents are overweight or obese .',
  'Obstructive sleep apnoea ( OSA ) is a serious worldwide health problem .',
  'Sleep disturbance is a serious health concern among asthma patients .',
  'Respiratory disorders during sleep are a serious medical , economic and social problem .',
  'Obstructive sleep apnea ( OSA ) is a serious , common , and underdiagnosed disorder that challenges health care resources .'],
 'shigella': ['High attack rates , increasing resistance to antibiotics and high mortality make shigellosis a serious problem .',
  'Antimicrobial resistance of Shigella is a serious public health problem and it is important to consider the susceptibility profile of isolates before determining treatment .',
  'The rapid emergence of drug-resistant Shigella sonnei is a serious public health problem .',
  'Shigella , which are highly epidemic and pathogenic , have become a serious public health problem .',
  'Bacterial dysentery due to Shigella sonnei remains a serious public health problem in developed countries , including Bulgaria .',
  'Shigella has been encountered by widespread resistance to commonly used antibiotics which is a serious concern .',
  'The data presented document the emergence of antibiotic resistance as a serious public health problem among strains of Shigella isolated at a large medical center in Israel .',
  'Shigellosis is a serious public health problem in Korea , because large outbreaks of Shigella sonnei infections were recorded in many parts of the country during the period 1998 - 2000 .',
  'High rates of multidrug resistance in Shigella spp . are a serious public health concern in Brazil .',
  'Shigellosis remains a serious public health problem and an important cause of morbidity and mortality worldwide .',
  'The emergence of multidrug resistance ( MDR ) is a serious problem in treating shigellosis .',
  'Shigellosis is a serious problem in Guizhou and Shigella sonnei is an increasingly prevalent etiologic agent of local shigellosis cases .'],
 'shigellosis': ['High attack rates , increasing resistance to antibiotics and high mortality make shigellosis a serious problem .',
  'Antimicrobial resistance of Shigella is a serious public health problem and it is important to consider the susceptibility profile of isolates before determining treatment .',
  'The rapid emergence of drug-resistant Shigella sonnei is a serious public health problem .',
  'Shigella , which are highly epidemic and pathogenic , have become a serious public health problem .',
  'Bacterial dysentery due to Shigella sonnei remains a serious public health problem in developed countries , including Bulgaria .',
  'Shigella has been encountered by widespread resistance to commonly used antibiotics which is a serious concern .',
  'The data presented document the emergence of antibiotic resistance as a serious public health problem among strains of Shigella isolated at a large medical center in Israel .',
  'Shigellosis is a serious public health problem in Korea , because large outbreaks of Shigella sonnei infections were recorded in many parts of the country during the period 1998 - 2000 .',
  'High rates of multidrug resistance in Shigella spp . are a serious public health concern in Brazil .',
  'Shigellosis remains a serious public health problem and an important cause of morbidity and mortality worldwide .',
  'The emergence of multidrug resistance ( MDR ) is a serious problem in treating shigellosis .',
  'Shigellosis is a serious problem in Guizhou and Shigella sonnei is an increasingly prevalent etiologic agent of local shigellosis cases .'],
 'toxoplasmosis': ['Toxoplasma gondii infection may pose a severe medical problem especially in a congenital form and as an acquired infection in immunocompromised persons .',
  'Toxoplasmosis , caused by an obligate intracellular protozoan parasite Toxoplasma gondii , has been a serious clinical and veterinary problem .',
  "These results suggest that ' asymptomatic ' acquired toxoplasmosis might in fact represent a serious and highly underestimated public health as well as economic problem .",
  'Accordingly , it can be concluded that toxoplasmosis is a serious public health concern that has been ignored by the Ministry of Health .',
  'Toxoplasmic encephalitis ( TE ) continues to be a severe health problem despite the introduction of highly active antiretroviral therapy ( HAART ) .',
  'Our findings showed that small ruminants of the Multan District in Pakistan are toxoplasma seropositive and may pose a serious threat of public health concern in the region .',
  'Because of the risk of congenital toxoplasmosis , a lower risk of infection than that observed in our study can represent a serious health problem .',
  'The results from this work show the presence of infection and a high prevalence of antibodies against Toxocara spp . in the studied municipalities and indicate that toxocariasis poses a serious health problem to preschool children in Aragua state .',
  'Toxoplasmosis is a zoonotic disease , recognized as a serious public health problem worldwide .',
  'Toxoplasma gondii infection is a serious health problem of humans and animals worldwide .',
  'Toxoplasmic encephalitis ( TE ) , an opportunistic infection , is a severe health problem in immunocompromised patients .',
  'Usually asymptomatic in immunocompetent humans , toxoplasmosis is a serious clinical and veterinary problem often leading to lethal damage in an infected host .',
  'Visceral toxocariasis is a serious public health problem with a cosmopolitan distribution .',
  'Congenital toxoplasmosis is a serious health problem that can lead to miscarriage .',
  'Toxocara canis and Ancylostoma spp . are geohelmints that parasites dogs and can eventually affect humans , mainly children , causing visceral and cutaneous larva migrans respectively , constituting a serious public health problem .',
  'Infections with the intracellular protozoan parasite Toxoplasma gondii pose a serious public health problem and are of great economic importance worldwide .',
  'Symptomatic forms of toxoplasmosis are a serious public health problem and occur in around 10 - 20 % of the infected people .',
  'Recently , toxoplasmosis associated with neurological complications as an opportunistic infection is a serious problem in the immunocompromised hosts , especially in AIDS , but this infection is rare in immunologically normal adults .',
  'Toxoplasmosis , caused by the obligate intracellular protozoan parasite Toxoplasma gondii , has become a serious public health problem worldwide .'],
 'toxoplasma': ['Toxoplasma gondii infection may pose a severe medical problem especially in a congenital form and as an acquired infection in immunocompromised persons .',
  'Toxoplasmosis , caused by an obligate intracellular protozoan parasite Toxoplasma gondii , has been a serious clinical and veterinary problem .',
  "These results suggest that ' asymptomatic ' acquired toxoplasmosis might in fact represent a serious and highly underestimated public health as well as economic problem .",
  'Accordingly , it can be concluded that toxoplasmosis is a serious public health concern that has been ignored by the Ministry of Health .',
  'Toxoplasmic encephalitis ( TE ) continues to be a severe health problem despite the introduction of highly active antiretroviral therapy ( HAART ) .',
  'Our findings showed that small ruminants of the Multan District in Pakistan are toxoplasma seropositive and may pose a serious threat of public health concern in the region .',
  'Because of the risk of congenital toxoplasmosis , a lower risk of infection than that observed in our study can represent a serious health problem .',
  'The results from this work show the presence of infection and a high prevalence of antibodies against Toxocara spp . in the studied municipalities and indicate that toxocariasis poses a serious health problem to preschool children in Aragua state .',
  'Toxoplasmosis is a zoonotic disease , recognized as a serious public health problem worldwide .',
  'Toxoplasma gondii infection is a serious health problem of humans and animals worldwide .',
  'Toxoplasmic encephalitis ( TE ) , an opportunistic infection , is a severe health problem in immunocompromised patients .',
  'Usually asymptomatic in immunocompetent humans , toxoplasmosis is a serious clinical and veterinary problem often leading to lethal damage in an infected host .',
  'Visceral toxocariasis is a serious public health problem with a cosmopolitan distribution .',
  'Congenital toxoplasmosis is a serious health problem that can lead to miscarriage .',
  'Toxocara canis and Ancylostoma spp . are geohelmints that parasites dogs and can eventually affect humans , mainly children , causing visceral and cutaneous larva migrans respectively , constituting a serious public health problem .',
  'Infections with the intracellular protozoan parasite Toxoplasma gondii pose a serious public health problem and are of great economic importance worldwide .',
  'Symptomatic forms of toxoplasmosis are a serious public health problem and occur in around 10 - 20 % of the infected people .',
  'Recently , toxoplasmosis associated with neurological complications as an opportunistic infection is a serious problem in the immunocompromised hosts , especially in AIDS , but this infection is rare in immunologically normal adults .',
  'Toxoplasmosis , caused by the obligate intracellular protozoan parasite Toxoplasma gondii , has become a serious public health problem worldwide .'],
 'brucellosis': ['In epidemic regions of the world , brucellosis is a reemerging zoonosis with minimal mortality but is a serious public hygiene problem .',
  'In developing countries , brucellosis remains a serious problem , and the importance of its control has attracted little attention .',
  'Brucella spp . is a common zoonotic infection referred to as Brucellosis , and it is a serious public health problem around the world .',
  'Such a system has been discovered in the intracellular pathogen Brucella melitensis , a Gram-negative bacterium responsible for brucellosis , a worldwide zoonosis that remains a serious public health concern in countries',
  'In endemic areas , Brucella infections represent a serious public health problem that results in significant morbidity and economic losses .',
  'Brucellosis , a multisystem infectious disorder , continues to be a serious public health problem in some parts of the world .',
  'The gram-negative bacteria of the genus Brucella are facultative intracellular parasites that cause brucellosis , a world wide-distributed zoonotic disease that represents a serious problem for animal and human health .',
  'Human brucellosis is a serious problem in the Republic of Macedonia presenting with a high percentage of localized forms , relapses and therapeutic failures .',
  'Brucellosis is a serious public health problem primarily affecting livestock workers .',
  'Childhood brucellosis is still a severe problem in the eastern region of Turkey .',
  'brucellosis in Niger is a serious problem among cattle especially in the rural areas around Niamey and among sheep in the urban areas of Niamey .',
  'Human brucellosis represents a serious public health concern in Hulun Buir and requires a comprehensive epidemiologic analysis to define adapted control measures .',
  'Brucellosis remains a serious public health problem in Turkey .',
  'The Brucella melitensis chronic infection and drug resistance emerged as a severe health problem in humans and domestic cattle .',
  "Human brucellosis has become a severe public health problem in China 's Guangxi Province , and there has been higher prevalence of brucellosis in this region after 2010 .",
  'Our findings confirm that Brucella spp . circulates among dairy cattle supplying milk to urban consumers in West and Central Africa , posing a serious public health concern .',
  'Brucellosis is a serious public health problem in eastern Turkey .',
  'Brucellar arthritis remains a serious a problem in Mediterranean countries .',
  'Brucellosis is a serious public health problem in Ulanqab , which is a region located in the middle of the Inner Mongolia Autonomous Region adjacent to Shanxi and Hebei provinces .',
  'Brucellosis is a serious problem in Sicily .',
  'A sharp rise in both animal and human brucellosis incidence has become a serious problem .',
  'We conclude that seronegative cows vaccinated with RB51 which calved normally and shed B. abortus in the vaginal exudate after calving could be a serious problem because these cows are overlooked in routine diagnoses and are a source of Brucella infection .',
  'Human brucellosis , as a zoonosis , is a serious public health problem in many developing countries , including China .'],
 'brucella': ['In epidemic regions of the world , brucellosis is a reemerging zoonosis with minimal mortality but is a serious public hygiene problem .',
  'In developing countries , brucellosis remains a serious problem , and the importance of its control has attracted little attention .',
  'Brucella spp . is a common zoonotic infection referred to as Brucellosis , and it is a serious public health problem around the world .',
  'Such a system has been discovered in the intracellular pathogen Brucella melitensis , a Gram-negative bacterium responsible for brucellosis , a worldwide zoonosis that remains a serious public health concern in countries',
  'In endemic areas , Brucella infections represent a serious public health problem that results in significant morbidity and economic losses .',
  'Brucellosis , a multisystem infectious disorder , continues to be a serious public health problem in some parts of the world .',
  'The gram-negative bacteria of the genus Brucella are facultative intracellular parasites that cause brucellosis , a world wide-distributed zoonotic disease that represents a serious problem for animal and human health .',
  'Human brucellosis is a serious problem in the Republic of Macedonia presenting with a high percentage of localized forms , relapses and therapeutic failures .',
  'Brucellosis is a serious public health problem primarily affecting livestock workers .',
  'Childhood brucellosis is still a severe problem in the eastern region of Turkey .',
  'brucellosis in Niger is a serious problem among cattle especially in the rural areas around Niamey and among sheep in the urban areas of Niamey .',
  'Human brucellosis represents a serious public health concern in Hulun Buir and requires a comprehensive epidemiologic analysis to define adapted control measures .',
  'Brucellosis remains a serious public health problem in Turkey .',
  'The Brucella melitensis chronic infection and drug resistance emerged as a severe health problem in humans and domestic cattle .',
  "Human brucellosis has become a severe public health problem in China 's Guangxi Province , and there has been higher prevalence of brucellosis in this region after 2010 .",
  'Our findings confirm that Brucella spp . circulates among dairy cattle supplying milk to urban consumers in West and Central Africa , posing a serious public health concern .',
  'Brucellosis is a serious public health problem in eastern Turkey .',
  'Brucellar arthritis remains a serious a problem in Mediterranean countries .',
  'Brucellosis is a serious public health problem in Ulanqab , which is a region located in the middle of the Inner Mongolia Autonomous Region adjacent to Shanxi and Hebei provinces .',
  'Brucellosis is a serious problem in Sicily .',
  'A sharp rise in both animal and human brucellosis incidence has become a serious problem .',
  'We conclude that seronegative cows vaccinated with RB51 which calved normally and shed B. abortus in the vaginal exudate after calving could be a serious problem because these cows are overlooked in routine diagnoses and are a source of Brucella infection .',
  'Human brucellosis , as a zoonosis , is a serious public health problem in many developing countries , including China .'],
 'school': ['Clearly , a serious childhood problem exists among the children in this selected school district in Hawaii .',
  'Educational loan repayment/forgiveness programs : a creative solution to a serious problem .',
  'Children with low academic productivity in late elementary and junior high school present a vexing problem to parents and schools .',
  'Frequent or prolonged absence may be an indication that a student has a serious physical or emotional health problem , that he or she is engaged in problem behaviors with potentially serious health and social consequences , that other family members have physical or psychological problems , or that the student is reacting to an unfavorable school environment .',
  'School truancy is a serious concern in the U.S. , with far-reaching negative consequences .',
  'Truancy is a serious concern in the United States .',
  'Refusing to attend school is a serious problem that could lead to psychopathology .',
  'Findings demonstrate that dropout from PE/CPT is a serious problem and highlight the need for additional research that can guide the development of interventions to improve PE/CPT engagement and adherence .',
  'Higher family SES in 9th grade reduced the probability of students and their parents experiencing a serious health problem in high school , thereby promoting growth in academic achievement .',
  'Academic drop outs at the university level is a serious problem .',
  'Failure at school and grade retention is a serious concern among children , and their parents .',
  'Behaviorally maladjusted students represent a serious problem for schools .',
  'Drop-out is a serious problem in psychotherapy .',
  'School absence has been identified as a severe problem in Sweden , both at the individual level and for society as a whole .',
  "The high levels of psychological problems identified by teachers are a serious public health concern , as they are likely to impact negatively on children 's education , particularly given the large class sizes and limited resources in rural LMIC settings .",
  'Falling behind in class is a serious problem for university students as it can lead to social problems and increase the risk of suicide .',
  'School reintegration programmes provide support to both children absent from school as a result of a serious health problem and their teachers , but little is known regarding their efficacy , or the impact of the situation on teachers .',
  'School dropout is considered a serious problem in high schools in Norway .',
  "However , a review of researches on adults ' dropout shows that dropout is a serious problem for psychotherapy with adult patients .",
  'Truancy is a serious concern that affects most school districts in the United States ; however , we do not have accurate estimates of the prevalence of truancy due to inconsistent tracking and reporting practices of schools .'],
 'truancy': ['Clearly , a serious childhood problem exists among the children in this selected school district in Hawaii .',
  'Educational loan repayment/forgiveness programs : a creative solution to a serious problem .',
  'Children with low academic productivity in late elementary and junior high school present a vexing problem to parents and schools .',
  'Frequent or prolonged absence may be an indication that a student has a serious physical or emotional health problem , that he or she is engaged in problem behaviors with potentially serious health and social consequences , that other family members have physical or psychological problems , or that the student is reacting to an unfavorable school environment .',
  'School truancy is a serious concern in the U.S. , with far-reaching negative consequences .',
  'Truancy is a serious concern in the United States .',
  'Refusing to attend school is a serious problem that could lead to psychopathology .',
  'Findings demonstrate that dropout from PE/CPT is a serious problem and highlight the need for additional research that can guide the development of interventions to improve PE/CPT engagement and adherence .',
  'Higher family SES in 9th grade reduced the probability of students and their parents experiencing a serious health problem in high school , thereby promoting growth in academic achievement .',
  'Academic drop outs at the university level is a serious problem .',
  'Failure at school and grade retention is a serious concern among children , and their parents .',
  'Behaviorally maladjusted students represent a serious problem for schools .',
  'Drop-out is a serious problem in psychotherapy .',
  'School absence has been identified as a severe problem in Sweden , both at the individual level and for society as a whole .',
  "The high levels of psychological problems identified by teachers are a serious public health concern , as they are likely to impact negatively on children 's education , particularly given the large class sizes and limited resources in rural LMIC settings .",
  'Falling behind in class is a serious problem for university students as it can lead to social problems and increase the risk of suicide .',
  'School reintegration programmes provide support to both children absent from school as a result of a serious health problem and their teachers , but little is known regarding their efficacy , or the impact of the situation on teachers .',
  'School dropout is considered a serious problem in high schools in Norway .',
  "However , a review of researches on adults ' dropout shows that dropout is a serious problem for psychotherapy with adult patients .",
  'Truancy is a serious concern that affects most school districts in the United States ; however , we do not have accurate estimates of the prevalence of truancy due to inconsistent tracking and reporting practices of schools .'],
 'dropout': ['Clearly , a serious childhood problem exists among the children in this selected school district in Hawaii .',
  'Educational loan repayment/forgiveness programs : a creative solution to a serious problem .',
  'Children with low academic productivity in late elementary and junior high school present a vexing problem to parents and schools .',
  'Frequent or prolonged absence may be an indication that a student has a serious physical or emotional health problem , that he or she is engaged in problem behaviors with potentially serious health and social consequences , that other family members have physical or psychological problems , or that the student is reacting to an unfavorable school environment .',
  'School truancy is a serious concern in the U.S. , with far-reaching negative consequences .',
  'Truancy is a serious concern in the United States .',
  'Refusing to attend school is a serious problem that could lead to psychopathology .',
  'Findings demonstrate that dropout from PE/CPT is a serious problem and highlight the need for additional research that can guide the development of interventions to improve PE/CPT engagement and adherence .',
  'Higher family SES in 9th grade reduced the probability of students and their parents experiencing a serious health problem in high school , thereby promoting growth in academic achievement .',
  'Academic drop outs at the university level is a serious problem .',
  'Failure at school and grade retention is a serious concern among children , and their parents .',
  'Behaviorally maladjusted students represent a serious problem for schools .',
  'Drop-out is a serious problem in psychotherapy .',
  'School absence has been identified as a severe problem in Sweden , both at the individual level and for society as a whole .',
  "The high levels of psychological problems identified by teachers are a serious public health concern , as they are likely to impact negatively on children 's education , particularly given the large class sizes and limited resources in rural LMIC settings .",
  'Falling behind in class is a serious problem for university students as it can lead to social problems and increase the risk of suicide .',
  'School reintegration programmes provide support to both children absent from school as a result of a serious health problem and their teachers , but little is known regarding their efficacy , or the impact of the situation on teachers .',
  'School dropout is considered a serious problem in high schools in Norway .',
  "However , a review of researches on adults ' dropout shows that dropout is a serious problem for psychotherapy with adult patients .",
  'Truancy is a serious concern that affects most school districts in the United States ; however , we do not have accurate estimates of the prevalence of truancy due to inconsistent tracking and reporting practices of schools .'],
 'schools': ['Clearly , a serious childhood problem exists among the children in this selected school district in Hawaii .',
  'Educational loan repayment/forgiveness programs : a creative solution to a serious problem .',
  'Children with low academic productivity in late elementary and junior high school present a vexing problem to parents and schools .',
  'Frequent or prolonged absence may be an indication that a student has a serious physical or emotional health problem , that he or she is engaged in problem behaviors with potentially serious health and social consequences , that other family members have physical or psychological problems , or that the student is reacting to an unfavorable school environment .',
  'School truancy is a serious concern in the U.S. , with far-reaching negative consequences .',
  'Truancy is a serious concern in the United States .',
  'Refusing to attend school is a serious problem that could lead to psychopathology .',
  'Findings demonstrate that dropout from PE/CPT is a serious problem and highlight the need for additional research that can guide the development of interventions to improve PE/CPT engagement and adherence .',
  'Higher family SES in 9th grade reduced the probability of students and their parents experiencing a serious health problem in high school , thereby promoting growth in academic achievement .',
  'Academic drop outs at the university level is a serious problem .',
  'Failure at school and grade retention is a serious concern among children , and their parents .',
  'Behaviorally maladjusted students represent a serious problem for schools .',
  'Drop-out is a serious problem in psychotherapy .',
  'School absence has been identified as a severe problem in Sweden , both at the individual level and for society as a whole .',
  "The high levels of psychological problems identified by teachers are a serious public health concern , as they are likely to impact negatively on children 's education , particularly given the large class sizes and limited resources in rural LMIC settings .",
  'Falling behind in class is a serious problem for university students as it can lead to social problems and increase the risk of suicide .',
  'School reintegration programmes provide support to both children absent from school as a result of a serious health problem and their teachers , but little is known regarding their efficacy , or the impact of the situation on teachers .',
  'School dropout is considered a serious problem in high schools in Norway .',
  "However , a review of researches on adults ' dropout shows that dropout is a serious problem for psychotherapy with adult patients .",
  'Truancy is a serious concern that affects most school districts in the United States ; however , we do not have accurate estimates of the prevalence of truancy due to inconsistent tracking and reporting practices of schools .'],
 'scorpion': ['Envenoming caused by scorpion sting is a serious public health problem .',
  'Accidents caused by scorpions are a serious public health problem in Brazil .',
  'While scorpionism is not a serious public health problem in Spain , traditional Spanish knowledge has retained a large number of plant-based and animal-based remedies for scorpion stings .',
  'People in tropical and semi-tropical areas are in danger of scorpion sting , and this can be a serious problem for them .',
  'Scorpionism represents a serious public health problem resulting in the death of children and debilitated individuals .',
  'Scorpion envenoming is a serious public health problem in many areas in the world .',
  'Scorpionism is a serious public health problem in North Africa , sub-Saharan countries , and South Africa .',
  'Cnidarian stinging is a serious health problem for humans in the zones where extremely venomous jellyfish or anemones are common , such as in temperate and tropical oceanic waters and particularly along several Pacific coasts , and severe cases of envenomation , including also lethal cases mainly induced by cubomedusae , were reported .',
  'The high frequency of poisoning by sting or bite from venomous animals has begun to be a serious public health problem in Mexico where scorpion sting is the most common .',
  'The sting from Centuroides sculpturatus , commonly known as the bark scorpion , is a serious medical problem and can be potentially fatal to young children .',
  'Based on the results , scorpionism is a serious health problem in this area and increasing knowledge of residents regarding the prevention methods of scorpion stings is recommended .',
  'Stingrays from the Potamotrygon cf . henlei species are widely distributed in high numbers throughout the rivers of central-west Brazil , being the source of numerous envenomations occurring in the dry season , posing a serious public health problem even if not properly reported .',
  'In the state of Paraná , Brazil , loxoscelism is considered a serious public health problem , and Loxosceles intermedia Mello-Leitão ( Araneae : Sicariidae ) is associated with the majority of reported accidents .',
  'Scorpion sting envenomation is a life-threatening emergency and a common public health problem in many regions of the world , particularly in children .',
  'Scorpionism represents a serious public health problem due to its increasing incidence .',
  'Scorpionism is a serious public health problem in Brazil .',
  'Scorpion stings are a serious problem in Khuzestan , a southwestern province of Iran .',
  'Scorpionism is a serious public health problem in Brazil .',
  'Scorpion envenomation is a life-threatening health problem in tropical and subtropical regions , particularly among children .',
  'Scorpion envenoming is a serious health problem which can cause a variety of clinical toxic effects .',
  'Scorpion envenomation and its consequences represented a serious healthcare problem in Upper Egypt and considered to be an important cause of life-threatening emergency particularly in children .',
  'Scorpion envenomation is a life-threatening emergency and a common public health problem in many regions of the world , particularly in children .',
  'Unfortunately , however , scorpion envenomation represents a serious health problem in several countries , including Iran .'],
 'scorpionism': ['Envenoming caused by scorpion sting is a serious public health problem .',
  'Accidents caused by scorpions are a serious public health problem in Brazil .',
  'While scorpionism is not a serious public health problem in Spain , traditional Spanish knowledge has retained a large number of plant-based and animal-based remedies for scorpion stings .',
  'People in tropical and semi-tropical areas are in danger of scorpion sting , and this can be a serious problem for them .',
  'Scorpionism represents a serious public health problem resulting in the death of children and debilitated individuals .',
  'Scorpion envenoming is a serious public health problem in many areas in the world .',
  'Scorpionism is a serious public health problem in North Africa , sub-Saharan countries , and South Africa .',
  'Cnidarian stinging is a serious health problem for humans in the zones where extremely venomous jellyfish or anemones are common , such as in temperate and tropical oceanic waters and particularly along several Pacific coasts , and severe cases of envenomation , including also lethal cases mainly induced by cubomedusae , were reported .',
  'The high frequency of poisoning by sting or bite from venomous animals has begun to be a serious public health problem in Mexico where scorpion sting is the most common .',
  'The sting from Centuroides sculpturatus , commonly known as the bark scorpion , is a serious medical problem and can be potentially fatal to young children .',
  'Based on the results , scorpionism is a serious health problem in this area and increasing knowledge of residents regarding the prevention methods of scorpion stings is recommended .',
  'Stingrays from the Potamotrygon cf . henlei species are widely distributed in high numbers throughout the rivers of central-west Brazil , being the source of numerous envenomations occurring in the dry season , posing a serious public health problem even if not properly reported .',
  'In the state of Paraná , Brazil , loxoscelism is considered a serious public health problem , and Loxosceles intermedia Mello-Leitão ( Araneae : Sicariidae ) is associated with the majority of reported accidents .',
  'Scorpion sting envenomation is a life-threatening emergency and a common public health problem in many regions of the world , particularly in children .',
  'Scorpionism represents a serious public health problem due to its increasing incidence .',
  'Scorpionism is a serious public health problem in Brazil .',
  'Scorpion stings are a serious problem in Khuzestan , a southwestern province of Iran .',
  'Scorpionism is a serious public health problem in Brazil .',
  'Scorpion envenomation is a life-threatening health problem in tropical and subtropical regions , particularly among children .',
  'Scorpion envenoming is a serious health problem which can cause a variety of clinical toxic effects .',
  'Scorpion envenomation and its consequences represented a serious healthcare problem in Upper Egypt and considered to be an important cause of life-threatening emergency particularly in children .',
  'Scorpion envenomation is a life-threatening emergency and a common public health problem in many regions of the world , particularly in children .',
  'Unfortunately , however , scorpion envenomation represents a serious health problem in several countries , including Iran .'],
 'sting': ['Envenoming caused by scorpion sting is a serious public health problem .',
  'Accidents caused by scorpions are a serious public health problem in Brazil .',
  'While scorpionism is not a serious public health problem in Spain , traditional Spanish knowledge has retained a large number of plant-based and animal-based remedies for scorpion stings .',
  'People in tropical and semi-tropical areas are in danger of scorpion sting , and this can be a serious problem for them .',
  'Scorpionism represents a serious public health problem resulting in the death of children and debilitated individuals .',
  'Scorpion envenoming is a serious public health problem in many areas in the world .',
  'Scorpionism is a serious public health problem in North Africa , sub-Saharan countries , and South Africa .',
  'Cnidarian stinging is a serious health problem for humans in the zones where extremely venomous jellyfish or anemones are common , such as in temperate and tropical oceanic waters and particularly along several Pacific coasts , and severe cases of envenomation , including also lethal cases mainly induced by cubomedusae , were reported .',
  'The high frequency of poisoning by sting or bite from venomous animals has begun to be a serious public health problem in Mexico where scorpion sting is the most common .',
  'The sting from Centuroides sculpturatus , commonly known as the bark scorpion , is a serious medical problem and can be potentially fatal to young children .',
  'Based on the results , scorpionism is a serious health problem in this area and increasing knowledge of residents regarding the prevention methods of scorpion stings is recommended .',
  'Stingrays from the Potamotrygon cf . henlei species are widely distributed in high numbers throughout the rivers of central-west Brazil , being the source of numerous envenomations occurring in the dry season , posing a serious public health problem even if not properly reported .',
  'In the state of Paraná , Brazil , loxoscelism is considered a serious public health problem , and Loxosceles intermedia Mello-Leitão ( Araneae : Sicariidae ) is associated with the majority of reported accidents .',
  'Scorpion sting envenomation is a life-threatening emergency and a common public health problem in many regions of the world , particularly in children .',
  'Scorpionism represents a serious public health problem due to its increasing incidence .',
  'Scorpionism is a serious public health problem in Brazil .',
  'Scorpion stings are a serious problem in Khuzestan , a southwestern province of Iran .',
  'Scorpionism is a serious public health problem in Brazil .',
  'Scorpion envenomation is a life-threatening health problem in tropical and subtropical regions , particularly among children .',
  'Scorpion envenoming is a serious health problem which can cause a variety of clinical toxic effects .',
  'Scorpion envenomation and its consequences represented a serious healthcare problem in Upper Egypt and considered to be an important cause of life-threatening emergency particularly in children .',
  'Scorpion envenomation is a life-threatening emergency and a common public health problem in many regions of the world , particularly in children .',
  'Unfortunately , however , scorpion envenomation represents a serious health problem in several countries , including Iran .'],
 'phosphorus': ['Diffusion limitation of phosphate possibly constitutes a serious problem regarding the use of a biofilm reactor for enhanced biological phosphorus removal .',
  'Phosphogypsum ( PG ) is an acidic by-product from the phosphate fertilizer industry and it is characterized by a low nutrient availability and the presence of radionuclides and heavy metals which pose a serious problem in its management .',
  'Phosphorus ( P ) eutrophication of lakes and streams , coming from drained farmlands , is a serious problem in areas with intensive agriculture .',
  'Excessive P application through mineral fertilizer in the arable farming system has led to the accumulation of soil P and constituted a risk to the recipient water quality , whereas the grassland grazing system is confronted with a severe P deficit problem which has resulted in widespread grass degradation .',
  'Phosphorus in water eutrophication has become a serious problem threatening the environment .',
  'Phosphorus ( P ) leaching from agricultural soils is a serious environmental concern .',
  'Inorganic phosphate ( Pi ) depletion is a serious problem for plant growth .',
  'Phosphorus eutrophication of lakes and streams , coming from drained farmlands , is a serious problem in areas with intensive agriculture .',
  'Agricultural non-point source phosphorus pollution is a severe problem for rural water bodies in China , but hard to control directly because of its special characteristics .',
  'Nonpoint phosphorus ( P ) pollution from animal manure is becoming a serious global problem .',
  'Phosphorous ( P ) fixation in alkaline calcareous soils is a serious concern worldwide and acidified-biochar application has been proposed to improve the agronomic benefits of applied P. The present study aims to improve understanding of P transformation process in an alkaline soil following different biochar amendments ( rice-husk biochar ( RHB ) , sugarcane-bagasse biochar ( SWB ) and wheat-straw biochar ( WSB ) ) , chemically engineered ( acidification with 1 \xa0 N HCl or washing with distilled water ( pristine biochar ) ) along with or without P at 60 \xa0 mg \xa0 kg',
  'Phosphogypsum , a waste by-product derived from the wet process production of phosphoric acid , represents a serious problem facing the phosphate industry in Brazil .',
  'Shortage in phosphorus ( P ) resources and P wastewater pollution is considered as a serious problem worldwide .'],
 'phosphate': ['Diffusion limitation of phosphate possibly constitutes a serious problem regarding the use of a biofilm reactor for enhanced biological phosphorus removal .',
  'Phosphogypsum ( PG ) is an acidic by-product from the phosphate fertilizer industry and it is characterized by a low nutrient availability and the presence of radionuclides and heavy metals which pose a serious problem in its management .',
  'Phosphorus ( P ) eutrophication of lakes and streams , coming from drained farmlands , is a serious problem in areas with intensive agriculture .',
  'Excessive P application through mineral fertilizer in the arable farming system has led to the accumulation of soil P and constituted a risk to the recipient water quality , whereas the grassland grazing system is confronted with a severe P deficit problem which has resulted in widespread grass degradation .',
  'Phosphorus in water eutrophication has become a serious problem threatening the environment .',
  'Phosphorus ( P ) leaching from agricultural soils is a serious environmental concern .',
  'Inorganic phosphate ( Pi ) depletion is a serious problem for plant growth .',
  'Phosphorus eutrophication of lakes and streams , coming from drained farmlands , is a serious problem in areas with intensive agriculture .',
  'Agricultural non-point source phosphorus pollution is a severe problem for rural water bodies in China , but hard to control directly because of its special characteristics .',
  'Nonpoint phosphorus ( P ) pollution from animal manure is becoming a serious global problem .',
  'Phosphorous ( P ) fixation in alkaline calcareous soils is a serious concern worldwide and acidified-biochar application has been proposed to improve the agronomic benefits of applied P. The present study aims to improve understanding of P transformation process in an alkaline soil following different biochar amendments ( rice-husk biochar ( RHB ) , sugarcane-bagasse biochar ( SWB ) and wheat-straw biochar ( WSB ) ) , chemically engineered ( acidification with 1 \xa0 N HCl or washing with distilled water ( pristine biochar ) ) along with or without P at 60 \xa0 mg \xa0 kg',
  'Phosphogypsum , a waste by-product derived from the wet process production of phosphoric acid , represents a serious problem facing the phosphate industry in Brazil .',
  'Shortage in phosphorus ( P ) resources and P wastewater pollution is considered as a serious problem worldwide .'],
 'phosphogypsum': ['Diffusion limitation of phosphate possibly constitutes a serious problem regarding the use of a biofilm reactor for enhanced biological phosphorus removal .',
  'Phosphogypsum ( PG ) is an acidic by-product from the phosphate fertilizer industry and it is characterized by a low nutrient availability and the presence of radionuclides and heavy metals which pose a serious problem in its management .',
  'Phosphorus ( P ) eutrophication of lakes and streams , coming from drained farmlands , is a serious problem in areas with intensive agriculture .',
  'Excessive P application through mineral fertilizer in the arable farming system has led to the accumulation of soil P and constituted a risk to the recipient water quality , whereas the grassland grazing system is confronted with a severe P deficit problem which has resulted in widespread grass degradation .',
  'Phosphorus in water eutrophication has become a serious problem threatening the environment .',
  'Phosphorus ( P ) leaching from agricultural soils is a serious environmental concern .',
  'Inorganic phosphate ( Pi ) depletion is a serious problem for plant growth .',
  'Phosphorus eutrophication of lakes and streams , coming from drained farmlands , is a serious problem in areas with intensive agriculture .',
  'Agricultural non-point source phosphorus pollution is a severe problem for rural water bodies in China , but hard to control directly because of its special characteristics .',
  'Nonpoint phosphorus ( P ) pollution from animal manure is becoming a serious global problem .',
  'Phosphorous ( P ) fixation in alkaline calcareous soils is a serious concern worldwide and acidified-biochar application has been proposed to improve the agronomic benefits of applied P. The present study aims to improve understanding of P transformation process in an alkaline soil following different biochar amendments ( rice-husk biochar ( RHB ) , sugarcane-bagasse biochar ( SWB ) and wheat-straw biochar ( WSB ) ) , chemically engineered ( acidification with 1 \xa0 N HCl or washing with distilled water ( pristine biochar ) ) along with or without P at 60 \xa0 mg \xa0 kg',
  'Phosphogypsum , a waste by-product derived from the wet process production of phosphoric acid , represents a serious problem facing the phosphate industry in Brazil .',
  'Shortage in phosphorus ( P ) resources and P wastewater pollution is considered as a serious problem worldwide .'],
 'farmlands': ['Diffusion limitation of phosphate possibly constitutes a serious problem regarding the use of a biofilm reactor for enhanced biological phosphorus removal .',
  'Phosphogypsum ( PG ) is an acidic by-product from the phosphate fertilizer industry and it is characterized by a low nutrient availability and the presence of radionuclides and heavy metals which pose a serious problem in its management .',
  'Phosphorus ( P ) eutrophication of lakes and streams , coming from drained farmlands , is a serious problem in areas with intensive agriculture .',
  'Excessive P application through mineral fertilizer in the arable farming system has led to the accumulation of soil P and constituted a risk to the recipient water quality , whereas the grassland grazing system is confronted with a severe P deficit problem which has resulted in widespread grass degradation .',
  'Phosphorus in water eutrophication has become a serious problem threatening the environment .',
  'Phosphorus ( P ) leaching from agricultural soils is a serious environmental concern .',
  'Inorganic phosphate ( Pi ) depletion is a serious problem for plant growth .',
  'Phosphorus eutrophication of lakes and streams , coming from drained farmlands , is a serious problem in areas with intensive agriculture .',
  'Agricultural non-point source phosphorus pollution is a severe problem for rural water bodies in China , but hard to control directly because of its special characteristics .',
  'Nonpoint phosphorus ( P ) pollution from animal manure is becoming a serious global problem .',
  'Phosphorous ( P ) fixation in alkaline calcareous soils is a serious concern worldwide and acidified-biochar application has been proposed to improve the agronomic benefits of applied P. The present study aims to improve understanding of P transformation process in an alkaline soil following different biochar amendments ( rice-husk biochar ( RHB ) , sugarcane-bagasse biochar ( SWB ) and wheat-straw biochar ( WSB ) ) , chemically engineered ( acidification with 1 \xa0 N HCl or washing with distilled water ( pristine biochar ) ) along with or without P at 60 \xa0 mg \xa0 kg',
  'Phosphogypsum , a waste by-product derived from the wet process production of phosphoric acid , represents a serious problem facing the phosphate industry in Brazil .',
  'Shortage in phosphorus ( P ) resources and P wastewater pollution is considered as a serious problem worldwide .'],
 'monocytogenes': ['Listeriosis is a serious foodborne disease of a global concern , and can effectively be controlled by a continuous surveillance of the virulent and multidrug-resistant strains of Listeria monocytogenes .',
  'Listeria monocytogenes is a food-borne human pathogen and a serious concern in food production and preservation .',
  'Foodborne illness caused by L. monocytogenes is a serious public health concern because of the high associated mortality .',
  'Airway infections with Listeria monocytogenes , although representing a serious problem in early onset neonatal listeriosis , has not been investigated in detail in animal models so far .',
  'The Gram-positive bacterium Listeria monocytogenes is a human foodborne pathogen that remains a serious public health concern .',
  'The model was applied to ovine listeriosis , which is a serious disease problem in Norway .',
  'Listeria monocytogenes , the etiologic agent of listeriosis , remains a serious public health concern , with its frequent occurrence in food environments coupled with a high mortality rate .',
  'Listeria monocytogenes , the etiologic agent of listeriosis , remains a serious public health concern with its frequent occurrence in food coupled with a high mortality rate .',
  'Listeria monocytogenes is an important cause of human foodborne infections and its ability to form biofilms is a serious concern to the food industry .',
  'Listeria monocytogenes , a foodborne pathogenic bacterium , remains a serious public health concern due to its frequent occurrence in food products coupled with a high mortality rate .',
  "Changes in consumers ' habits have led to an increase of convenient LPFP with a relative long shelf-life ( at least 3 weeks ) which , on the other hand , may constitute a serious problem from a safety perspective since Listeria monocytogenes and sometimes Clostridium botulinum ( mainly type E ) may able to grow .",
  'Listeriosis is a serious problem because of the high mortality in case of generalized infection , which can reach up to 20 % .'],
 'listeria': ['Listeriosis is a serious foodborne disease of a global concern , and can effectively be controlled by a continuous surveillance of the virulent and multidrug-resistant strains of Listeria monocytogenes .',
  'Listeria monocytogenes is a food-borne human pathogen and a serious concern in food production and preservation .',
  'Foodborne illness caused by L. monocytogenes is a serious public health concern because of the high associated mortality .',
  'Airway infections with Listeria monocytogenes , although representing a serious problem in early onset neonatal listeriosis , has not been investigated in detail in animal models so far .',
  'The Gram-positive bacterium Listeria monocytogenes is a human foodborne pathogen that remains a serious public health concern .',
  'The model was applied to ovine listeriosis , which is a serious disease problem in Norway .',
  'Listeria monocytogenes , the etiologic agent of listeriosis , remains a serious public health concern , with its frequent occurrence in food environments coupled with a high mortality rate .',
  'Listeria monocytogenes , the etiologic agent of listeriosis , remains a serious public health concern with its frequent occurrence in food coupled with a high mortality rate .',
  'Listeria monocytogenes is an important cause of human foodborne infections and its ability to form biofilms is a serious concern to the food industry .',
  'Listeria monocytogenes , a foodborne pathogenic bacterium , remains a serious public health concern due to its frequent occurrence in food products coupled with a high mortality rate .',
  "Changes in consumers ' habits have led to an increase of convenient LPFP with a relative long shelf-life ( at least 3 weeks ) which , on the other hand , may constitute a serious problem from a safety perspective since Listeria monocytogenes and sometimes Clostridium botulinum ( mainly type E ) may able to grow .",
  'Listeriosis is a serious problem because of the high mortality in case of generalized infection , which can reach up to 20 % .'],
 'listeriosis': ['Listeriosis is a serious foodborne disease of a global concern , and can effectively be controlled by a continuous surveillance of the virulent and multidrug-resistant strains of Listeria monocytogenes .',
  'Listeria monocytogenes is a food-borne human pathogen and a serious concern in food production and preservation .',
  'Foodborne illness caused by L. monocytogenes is a serious public health concern because of the high associated mortality .',
  'Airway infections with Listeria monocytogenes , although representing a serious problem in early onset neonatal listeriosis , has not been investigated in detail in animal models so far .',
  'The Gram-positive bacterium Listeria monocytogenes is a human foodborne pathogen that remains a serious public health concern .',
  'The model was applied to ovine listeriosis , which is a serious disease problem in Norway .',
  'Listeria monocytogenes , the etiologic agent of listeriosis , remains a serious public health concern , with its frequent occurrence in food environments coupled with a high mortality rate .',
  'Listeria monocytogenes , the etiologic agent of listeriosis , remains a serious public health concern with its frequent occurrence in food coupled with a high mortality rate .',
  'Listeria monocytogenes is an important cause of human foodborne infections and its ability to form biofilms is a serious concern to the food industry .',
  'Listeria monocytogenes , a foodborne pathogenic bacterium , remains a serious public health concern due to its frequent occurrence in food products coupled with a high mortality rate .',
  "Changes in consumers ' habits have led to an increase of convenient LPFP with a relative long shelf-life ( at least 3 weeks ) which , on the other hand , may constitute a serious problem from a safety perspective since Listeria monocytogenes and sometimes Clostridium botulinum ( mainly type E ) may able to grow .",
  'Listeriosis is a serious problem because of the high mortality in case of generalized infection , which can reach up to 20 % .'],
 'kpc': ['We detected and reported the first Japanese case of KPC-2 carbapenemase-producing Klebsiella pneumoniae , of which infection will be a serious problem in the near future in Japan .',
  'The Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae has become a serious problem because the species is wide ranging and there are few treatment options .',
  'The increasing incidence of carbapenemase-producing K. pneumoniae strains ( CP-Kps ) in the last decade has become a serious global healthcare problem .',
  'Within the last decade , human infections caused by enterobacteria which produce the Klebsiella pneumoniae carbapenemase ( KPC ) became a serious therapeutic and epidemiological problem worldwide .',
  'Carbapenem-resistant Klebsiella pneumoniae ( CRKP ) spread and infections in patients with haematological malignancies are a serious concern especially in endemic areas .',
  'KPC-producing Klebsiella pneumoniae ( KPC-Kp ) represent a serious problem worldwide .',
  'The emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management .',
  'Carbapenem-resistant Klebsiella pneumoniae ( CRKP ) infection is a serious problem in hospitals worldwide , posing a particular risk to immunocompromised patients .',
  'The spread of carbapenemase-producing Klebsiella pneumoniae ( CPKP ) worldwide is a serious problem .',
  'The outbreak of carbapenem-resistant Klebsiella pneumoniae is a serious public health problem , especially in the neonatal intensive care unit (NICU).Fifteen K. pneumoniae strains were isolated from 7 neonates during June 3 to 28 , 2017 in an NICU .'],
 'crkp': ['We detected and reported the first Japanese case of KPC-2 carbapenemase-producing Klebsiella pneumoniae , of which infection will be a serious problem in the near future in Japan .',
  'The Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae has become a serious problem because the species is wide ranging and there are few treatment options .',
  'The increasing incidence of carbapenemase-producing K. pneumoniae strains ( CP-Kps ) in the last decade has become a serious global healthcare problem .',
  'Within the last decade , human infections caused by enterobacteria which produce the Klebsiella pneumoniae carbapenemase ( KPC ) became a serious therapeutic and epidemiological problem worldwide .',
  'Carbapenem-resistant Klebsiella pneumoniae ( CRKP ) spread and infections in patients with haematological malignancies are a serious concern especially in endemic areas .',
  'KPC-producing Klebsiella pneumoniae ( KPC-Kp ) represent a serious problem worldwide .',
  'The emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management .',
  'Carbapenem-resistant Klebsiella pneumoniae ( CRKP ) infection is a serious problem in hospitals worldwide , posing a particular risk to immunocompromised patients .',
  'The spread of carbapenemase-producing Klebsiella pneumoniae ( CPKP ) worldwide is a serious problem .',
  'The outbreak of carbapenem-resistant Klebsiella pneumoniae is a serious public health problem , especially in the neonatal intensive care unit (NICU).Fifteen K. pneumoniae strains were isolated from 7 neonates during June 3 to 28 , 2017 in an NICU .'],
 'nicu': ['We detected and reported the first Japanese case of KPC-2 carbapenemase-producing Klebsiella pneumoniae , of which infection will be a serious problem in the near future in Japan .',
  'The Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae has become a serious problem because the species is wide ranging and there are few treatment options .',
  'The increasing incidence of carbapenemase-producing K. pneumoniae strains ( CP-Kps ) in the last decade has become a serious global healthcare problem .',
  'Within the last decade , human infections caused by enterobacteria which produce the Klebsiella pneumoniae carbapenemase ( KPC ) became a serious therapeutic and epidemiological problem worldwide .',
  'Carbapenem-resistant Klebsiella pneumoniae ( CRKP ) spread and infections in patients with haematological malignancies are a serious concern especially in endemic areas .',
  'KPC-producing Klebsiella pneumoniae ( KPC-Kp ) represent a serious problem worldwide .',
  'The emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management .',
  'Carbapenem-resistant Klebsiella pneumoniae ( CRKP ) infection is a serious problem in hospitals worldwide , posing a particular risk to immunocompromised patients .',
  'The spread of carbapenemase-producing Klebsiella pneumoniae ( CPKP ) worldwide is a serious problem .',
  'The outbreak of carbapenem-resistant Klebsiella pneumoniae is a serious public health problem , especially in the neonatal intensive care unit (NICU).Fifteen K. pneumoniae strains were isolated from 7 neonates during June 3 to 28 , 2017 in an NICU .'],
 'neutropenia': ['Thirty-four previously untreated patients with oat cell carcinoma of the lung were treated with a myelotoxic combination of cyclophosphamide , adriamycin , methotrexate , CCNU , and Corynebacterium parvum ( regimen A ) every 4 weeks , interspersed with a non-myelotoxic combination including bleomycin , vincristine , dehydroemetine , and Corynebacterium parvum ( regimen B ) weekly the other 3 weeks or when hematologic toxicity prohibited administration of regimen A. Hematologic toxicity was frequent but was never a serious problem except in two cases of profound leukopenia in which fatal supervening infection occurred .',
  'The development of neutropenia in a patient undergoing therapy for cancer represents a serious medical problem that rapidly escalates if fever develops .',
  "Intensive chemotherapy ( CHT ) in AIDS-related non-Hodgkin 's lymphoma ( AIDS-NHL patients ) is a vexing problem .",
  'These studies may indicate that alpha-tocopherol succinate can be used as an adjunct in cancer chemotherapy , where neutropenia is a serious problem with threatening infectious complications .',
  'Chemotherapy-induced neutropenia , the depth and length of which are correlated to the risk of febrile neutropenia ( FN ) and neutropenia sepsis , remains a serious problem in medical oncology .',
  'Infection remains a serious problem in the management of children with leukemia .',
  'Infections continue to be a serious problem for severely neutropenic oncology and haematopoietic progenitor cell ( HPC ) transplant patients .',
  'Intolerable malodor emanating from ulcerated tumors as a result of anaerobic infection is a serious problem in the management of advanced and recurrent breast cancer .',
  'E. coli pyomyositis has emerged as a serious problem among our patients with hematologic malignancy .',
  'Infection in those treated by CAPD was a serious problem and may be exacerbated by aggressive chemotherapy .',
  'Infectious complications that arise during the treatment of children with acute leukemia with chemotherapeutic agents at high doses represent a serious problem in oncohematology .',
  'Although infection remains a serious problem in leukemia patients , considerable progress has been made .',
  'Immmunosuppression and infectious disease in cancer patients receiving chemotherapy is a serious problem .',
  'Bacterial infections in patients with hematologic malignancies still represent a severe and life-treating problem .'],
 'hematologic': ['Thirty-four previously untreated patients with oat cell carcinoma of the lung were treated with a myelotoxic combination of cyclophosphamide , adriamycin , methotrexate , CCNU , and Corynebacterium parvum ( regimen A ) every 4 weeks , interspersed with a non-myelotoxic combination including bleomycin , vincristine , dehydroemetine , and Corynebacterium parvum ( regimen B ) weekly the other 3 weeks or when hematologic toxicity prohibited administration of regimen A. Hematologic toxicity was frequent but was never a serious problem except in two cases of profound leukopenia in which fatal supervening infection occurred .',
  'The development of neutropenia in a patient undergoing therapy for cancer represents a serious medical problem that rapidly escalates if fever develops .',
  "Intensive chemotherapy ( CHT ) in AIDS-related non-Hodgkin 's lymphoma ( AIDS-NHL patients ) is a vexing problem .",
  'These studies may indicate that alpha-tocopherol succinate can be used as an adjunct in cancer chemotherapy , where neutropenia is a serious problem with threatening infectious complications .',
  'Chemotherapy-induced neutropenia , the depth and length of which are correlated to the risk of febrile neutropenia ( FN ) and neutropenia sepsis , remains a serious problem in medical oncology .',
  'Infection remains a serious problem in the management of children with leukemia .',
  'Infections continue to be a serious problem for severely neutropenic oncology and haematopoietic progenitor cell ( HPC ) transplant patients .',
  'Intolerable malodor emanating from ulcerated tumors as a result of anaerobic infection is a serious problem in the management of advanced and recurrent breast cancer .',
  'E. coli pyomyositis has emerged as a serious problem among our patients with hematologic malignancy .',
  'Infection in those treated by CAPD was a serious problem and may be exacerbated by aggressive chemotherapy .',
  'Infectious complications that arise during the treatment of children with acute leukemia with chemotherapeutic agents at high doses represent a serious problem in oncohematology .',
  'Although infection remains a serious problem in leukemia patients , considerable progress has been made .',
  'Immmunosuppression and infectious disease in cancer patients receiving chemotherapy is a serious problem .',
  'Bacterial infections in patients with hematologic malignancies still represent a severe and life-treating problem .'],
 'myelotoxic': ['Thirty-four previously untreated patients with oat cell carcinoma of the lung were treated with a myelotoxic combination of cyclophosphamide , adriamycin , methotrexate , CCNU , and Corynebacterium parvum ( regimen A ) every 4 weeks , interspersed with a non-myelotoxic combination including bleomycin , vincristine , dehydroemetine , and Corynebacterium parvum ( regimen B ) weekly the other 3 weeks or when hematologic toxicity prohibited administration of regimen A. Hematologic toxicity was frequent but was never a serious problem except in two cases of profound leukopenia in which fatal supervening infection occurred .',
  'The development of neutropenia in a patient undergoing therapy for cancer represents a serious medical problem that rapidly escalates if fever develops .',
  "Intensive chemotherapy ( CHT ) in AIDS-related non-Hodgkin 's lymphoma ( AIDS-NHL patients ) is a vexing problem .",
  'These studies may indicate that alpha-tocopherol succinate can be used as an adjunct in cancer chemotherapy , where neutropenia is a serious problem with threatening infectious complications .',
  'Chemotherapy-induced neutropenia , the depth and length of which are correlated to the risk of febrile neutropenia ( FN ) and neutropenia sepsis , remains a serious problem in medical oncology .',
  'Infection remains a serious problem in the management of children with leukemia .',
  'Infections continue to be a serious problem for severely neutropenic oncology and haematopoietic progenitor cell ( HPC ) transplant patients .',
  'Intolerable malodor emanating from ulcerated tumors as a result of anaerobic infection is a serious problem in the management of advanced and recurrent breast cancer .',
  'E. coli pyomyositis has emerged as a serious problem among our patients with hematologic malignancy .',
  'Infection in those treated by CAPD was a serious problem and may be exacerbated by aggressive chemotherapy .',
  'Infectious complications that arise during the treatment of children with acute leukemia with chemotherapeutic agents at high doses represent a serious problem in oncohematology .',
  'Although infection remains a serious problem in leukemia patients , considerable progress has been made .',
  'Immmunosuppression and infectious disease in cancer patients receiving chemotherapy is a serious problem .',
  'Bacterial infections in patients with hematologic malignancies still represent a severe and life-treating problem .'],
 'corynebacterium': ['Thirty-four previously untreated patients with oat cell carcinoma of the lung were treated with a myelotoxic combination of cyclophosphamide , adriamycin , methotrexate , CCNU , and Corynebacterium parvum ( regimen A ) every 4 weeks , interspersed with a non-myelotoxic combination including bleomycin , vincristine , dehydroemetine , and Corynebacterium parvum ( regimen B ) weekly the other 3 weeks or when hematologic toxicity prohibited administration of regimen A. Hematologic toxicity was frequent but was never a serious problem except in two cases of profound leukopenia in which fatal supervening infection occurred .',
  'The development of neutropenia in a patient undergoing therapy for cancer represents a serious medical problem that rapidly escalates if fever develops .',
  "Intensive chemotherapy ( CHT ) in AIDS-related non-Hodgkin 's lymphoma ( AIDS-NHL patients ) is a vexing problem .",
  'These studies may indicate that alpha-tocopherol succinate can be used as an adjunct in cancer chemotherapy , where neutropenia is a serious problem with threatening infectious complications .',
  'Chemotherapy-induced neutropenia , the depth and length of which are correlated to the risk of febrile neutropenia ( FN ) and neutropenia sepsis , remains a serious problem in medical oncology .',
  'Infection remains a serious problem in the management of children with leukemia .',
  'Infections continue to be a serious problem for severely neutropenic oncology and haematopoietic progenitor cell ( HPC ) transplant patients .',
  'Intolerable malodor emanating from ulcerated tumors as a result of anaerobic infection is a serious problem in the management of advanced and recurrent breast cancer .',
  'E. coli pyomyositis has emerged as a serious problem among our patients with hematologic malignancy .',
  'Infection in those treated by CAPD was a serious problem and may be exacerbated by aggressive chemotherapy .',
  'Infectious complications that arise during the treatment of children with acute leukemia with chemotherapeutic agents at high doses represent a serious problem in oncohematology .',
  'Although infection remains a serious problem in leukemia patients , considerable progress has been made .',
  'Immmunosuppression and infectious disease in cancer patients receiving chemotherapy is a serious problem .',
  'Bacterial infections in patients with hematologic malignancies still represent a severe and life-treating problem .'],
 'hospitals': ["During interventions , patients ' accidental falls from the bed are a serious problem , and spe-cialized fixation systems for hemodialysis patients to prevent their falls from the bed have been lacking .",
  'Crowded emergency departments ( EDs ) have become a serious problem in the current U.S. healthcare system .',
  'Falls are a serious problem for hospitalized patients , reducing the duration and quality of life .',
  'Fall events and their severe consequences represent not only a threatening problem for the affected individual , but also cause a significant burden for health care systems .',
  'Patient falls are a serious problem in hospitals , resulting in substantial morbidity , mortality , length of stay , and costs .',
  'Falls are a serious , persistent problem in hospitals .',
  'Overcrowding of emergency rooms still a serious problem for Georgia hospitals .',
  'Hospital and emergency department overcrowding is a serious and growing problem nationwide .',
  'Falls are a globally common , important , and a preventable problem .',
  'Overcrowding is perceived to be a serious problem by emergency department directors .',
  'Moreover , overcrowding in correctional facilities has become a serious problem necessitating a solution .',
  'The lack of designated beds was a serious problem in two jurisdictions of Kinki and the Hokkaido Regional Bureau of Health and Welfare , with a " designated bed sufficient ratio " of 0.08 and 0.00 , respectively .',
  'Emergency medical services ( EMS ) personnel attrition is a serious concern .',
  'This study demonstrates that falls are a serious safety concern in the workplace .',
  'Among medical accidents , accidental falls remain a serious problem .',
  'Patient falls in hospitals are a serious problem and can cause long delays in their recovery .',
  'Use of ambulances for nonemergency and routine transportation is thought to be a serious and growing problem .',
  'Patient falls constitute a serious problem both for the persons fallen and for the institutions involved .',
  'The emergency department on-call backup crisis : finding remedies for a serious public health problem .',
  'Emergency department ( ED ) crowding is a serious problem in most tertiary hospitals in Korea .',
  'The high frequency of fall accidents is a serious problem in Japan .',
  'Falls from height , particularly from roofs in Diyarbakir , remain a serious problem in terms of public health .',
  '[ Pediatric emergency duty in hospitals , a serious current problem requiring immediate solution ] .',
  'Emergency department ( ED ) overcrowding is a severe health care concern , while anxiety and depression rates among ED patients have been reported to be substantially higher compared to the general population .',
  'Falls are a serious public health problem and possibly life threatening for people in fall risk groups .',
  'Most calls are routine , but one where the caller is reporting a serious infraction can save an organization millions of dollars by forestalling a false claim or allowing for voluntary resolution of a problem . If your company has run a hotline unsuccessfully and earned a poor reputation with employees , outsourcing may be the best option .',
  'Overcrowding in hospitals , especially in EDs , is a serious problem in the United States , Europe , and Taiwan .',
  'Patient falls in hospitals continue to exist as a serious societal problem .',
  'Inpatient falls , many resulting in injury or death , are a serious problem in hospital settings .',
  'Emergency department overcrowding is a serious problem nationwide .',
  'Emergency department ( ED ) overcrowding has been a serious issue on the national agenda for the past 2 decades and is rapidly becoming an increasingly significant problem for children .',
  'Patient fall has been a severe problem in healthcare facilities around the world due to its prevalence and cost .'],
 'overcrowding': ['Crowded emergency departments ( EDs ) have become a serious problem in the current U.S. healthcare system .',
  'Overcrowding of emergency rooms still a serious problem for Georgia hospitals .',
  'Hospital and emergency department overcrowding is a serious and growing problem nationwide .',
  'Overcrowding is perceived to be a serious problem by emergency department directors .',
  'Moreover , overcrowding in correctional facilities has become a serious problem necessitating a solution .',
  'The lack of designated beds was a serious problem in two jurisdictions of Kinki and the Hokkaido Regional Bureau of Health and Welfare , with a " designated bed sufficient ratio " of 0.08 and 0.00 , respectively .',
  'Emergency medical services ( EMS ) personnel attrition is a serious concern .',
  'Use of ambulances for nonemergency and routine transportation is thought to be a serious and growing problem .',
  'The emergency department on-call backup crisis : finding remedies for a serious public health problem .',
  'Emergency department ( ED ) crowding is a serious problem in most tertiary hospitals in Korea .',
  '[ Pediatric emergency duty in hospitals , a serious current problem requiring immediate solution ] .',
  'Emergency department ( ED ) overcrowding is a severe health care concern , while anxiety and depression rates among ED patients have been reported to be substantially higher compared to the general population .',
  'Most calls are routine , but one where the caller is reporting a serious infraction can save an organization millions of dollars by forestalling a false claim or allowing for voluntary resolution of a problem . If your company has run a hotline unsuccessfully and earned a poor reputation with employees , outsourcing may be the best option .',
  'Overcrowding in hospitals , especially in EDs , is a serious problem in the United States , Europe , and Taiwan .',
  'Emergency department overcrowding is a serious problem nationwide .',
  'Emergency department ( ED ) overcrowding has been a serious issue on the national agenda for the past 2 decades and is rapidly becoming an increasingly significant problem for children .'],
 'emergency': ['Crowded emergency departments ( EDs ) have become a serious problem in the current U.S. healthcare system .',
  'Overcrowding of emergency rooms still a serious problem for Georgia hospitals .',
  'Hospital and emergency department overcrowding is a serious and growing problem nationwide .',
  'Overcrowding is perceived to be a serious problem by emergency department directors .',
  'Moreover , overcrowding in correctional facilities has become a serious problem necessitating a solution .',
  'The lack of designated beds was a serious problem in two jurisdictions of Kinki and the Hokkaido Regional Bureau of Health and Welfare , with a " designated bed sufficient ratio " of 0.08 and 0.00 , respectively .',
  'Emergency medical services ( EMS ) personnel attrition is a serious concern .',
  'Use of ambulances for nonemergency and routine transportation is thought to be a serious and growing problem .',
  'The emergency department on-call backup crisis : finding remedies for a serious public health problem .',
  'Emergency department ( ED ) crowding is a serious problem in most tertiary hospitals in Korea .',
  '[ Pediatric emergency duty in hospitals , a serious current problem requiring immediate solution ] .',
  'Emergency department ( ED ) overcrowding is a severe health care concern , while anxiety and depression rates among ED patients have been reported to be substantially higher compared to the general population .',
  'Most calls are routine , but one where the caller is reporting a serious infraction can save an organization millions of dollars by forestalling a false claim or allowing for voluntary resolution of a problem . If your company has run a hotline unsuccessfully and earned a poor reputation with employees , outsourcing may be the best option .',
  'Overcrowding in hospitals , especially in EDs , is a serious problem in the United States , Europe , and Taiwan .',
  'Emergency department overcrowding is a serious problem nationwide .',
  'Emergency department ( ED ) overcrowding has been a serious issue on the national agenda for the past 2 decades and is rapidly becoming an increasingly significant problem for children .'],
 'department': ['Crowded emergency departments ( EDs ) have become a serious problem in the current U.S. healthcare system .',
  'Overcrowding of emergency rooms still a serious problem for Georgia hospitals .',
  'Hospital and emergency department overcrowding is a serious and growing problem nationwide .',
  'Overcrowding is perceived to be a serious problem by emergency department directors .',
  'Moreover , overcrowding in correctional facilities has become a serious problem necessitating a solution .',
  'The lack of designated beds was a serious problem in two jurisdictions of Kinki and the Hokkaido Regional Bureau of Health and Welfare , with a " designated bed sufficient ratio " of 0.08 and 0.00 , respectively .',
  'Emergency medical services ( EMS ) personnel attrition is a serious concern .',
  'Use of ambulances for nonemergency and routine transportation is thought to be a serious and growing problem .',
  'The emergency department on-call backup crisis : finding remedies for a serious public health problem .',
  'Emergency department ( ED ) crowding is a serious problem in most tertiary hospitals in Korea .',
  '[ Pediatric emergency duty in hospitals , a serious current problem requiring immediate solution ] .',
  'Emergency department ( ED ) overcrowding is a severe health care concern , while anxiety and depression rates among ED patients have been reported to be substantially higher compared to the general population .',
  'Most calls are routine , but one where the caller is reporting a serious infraction can save an organization millions of dollars by forestalling a false claim or allowing for voluntary resolution of a problem . If your company has run a hotline unsuccessfully and earned a poor reputation with employees , outsourcing may be the best option .',
  'Overcrowding in hospitals , especially in EDs , is a serious problem in the United States , Europe , and Taiwan .',
  'Emergency department overcrowding is a serious problem nationwide .',
  'Emergency department ( ED ) overcrowding has been a serious issue on the national agenda for the past 2 decades and is rapidly becoming an increasingly significant problem for children .'],
 'pahs': ['Exposure to trace metals and polycyclic aromatic hydrocarbons ( PAHs ) adsorbed on particulates is of a serious health concern .',
  'Polycyclic aromatic hydrocarbons ( PAHs ) in street dust pose a serious problem threatening both the environment and human health .',
  'Contamination of polycyclic aromatic hydrocarbons ( PAHs ) in environment indicates a serious problem to the present era .',
  'Halogenations of polycyclic aromatic hydrocarbons ( PAHs ) comprise a serious problem , when electrochemical oxidation ( EO ) is applied for treatment of chloride and bromide containing polluted sea water .',
  'However , as environmental PAH concentrations build up , this may be a serious concern around the incinerator vicinity due to the potential consequences of PAHs on ecosystems and human health .',
  'Chlorinated polycyclic aromatic hydrocarbons ( ClPAHs ) have become a serious environmental concern due to their widespread occurrence and dioxin-like toxicities .',
  'Contamination of soils with polycyclic aromatic hydrocarbons ( PAHs ) is a serious problem in petroleum producing countries , such as México , and environment-friendly easy to apply techniques are required to accelerate the removal of the contaminants .',
  'Nowadays , contamination by polycyclic aromatic hydrocarbons ( PAHs ) has become a serious problem all over the world ; in particular , high-molecular-weight PAHs ( HWM PAHs , four to seven rings ) are more harmful to human health and environment due to their more complex structure and metabolic pathway .',
  'Polycyclic aromatic hydrocarbons ( PAHs ) pollution in urban river sediments is a serious problem to ecological systems and human health .',
  'PCB contamination of indoor air in public buildings by elastic sealants has proved to be a serious problem in West Berlin .',
  'Soil contamination with polycyclic aromatic hydrocarbons ( PAHs ) is a serious problem in Northeast China , especially in the steel industrial area .',
  'The intensive production of polycyclic aromatic hydrocarbons by anthropogenic activities is a serious environmental problem .',
  'Bioremediation of surface waters contaminated with polycyclic aromatic hydrocarbons ( PAHs ) is a serious problem , often limited by the low bioavailability of contaminants as a result of their low aqueous solubility .',
  'Nowadays , contamination of soil and marine sediments by polycyclic aromatic hydrocarbons ( PAHs ) has become a serious problem all over the world .',
  'Among the pollutants emitted , polycyclic aromatic hydrocarbons ( PAHs ) are a severe concern because of their carcinogenic and mutagenic properties .',
  'Atmospheric pollution by polycyclic aromatic hydrocarbons ( PAHs ) has become a serious problem , especially in Asia , as PAHs can severely affect ecologically important mountainous areas .'],
 'aromatic': ['Exposure to trace metals and polycyclic aromatic hydrocarbons ( PAHs ) adsorbed on particulates is of a serious health concern .',
  'Polycyclic aromatic hydrocarbons ( PAHs ) in street dust pose a serious problem threatening both the environment and human health .',
  'Contamination of polycyclic aromatic hydrocarbons ( PAHs ) in environment indicates a serious problem to the present era .',
  'Halogenations of polycyclic aromatic hydrocarbons ( PAHs ) comprise a serious problem , when electrochemical oxidation ( EO ) is applied for treatment of chloride and bromide containing polluted sea water .',
  'However , as environmental PAH concentrations build up , this may be a serious concern around the incinerator vicinity due to the potential consequences of PAHs on ecosystems and human health .',
  'Chlorinated polycyclic aromatic hydrocarbons ( ClPAHs ) have become a serious environmental concern due to their widespread occurrence and dioxin-like toxicities .',
  'Contamination of soils with polycyclic aromatic hydrocarbons ( PAHs ) is a serious problem in petroleum producing countries , such as México , and environment-friendly easy to apply techniques are required to accelerate the removal of the contaminants .',
  'Nowadays , contamination by polycyclic aromatic hydrocarbons ( PAHs ) has become a serious problem all over the world ; in particular , high-molecular-weight PAHs ( HWM PAHs , four to seven rings ) are more harmful to human health and environment due to their more complex structure and metabolic pathway .',
  'Polycyclic aromatic hydrocarbons ( PAHs ) pollution in urban river sediments is a serious problem to ecological systems and human health .',
  'PCB contamination of indoor air in public buildings by elastic sealants has proved to be a serious problem in West Berlin .',
  'Soil contamination with polycyclic aromatic hydrocarbons ( PAHs ) is a serious problem in Northeast China , especially in the steel industrial area .',
  'The intensive production of polycyclic aromatic hydrocarbons by anthropogenic activities is a serious environmental problem .',
  'Bioremediation of surface waters contaminated with polycyclic aromatic hydrocarbons ( PAHs ) is a serious problem , often limited by the low bioavailability of contaminants as a result of their low aqueous solubility .',
  'Nowadays , contamination of soil and marine sediments by polycyclic aromatic hydrocarbons ( PAHs ) has become a serious problem all over the world .',
  'Among the pollutants emitted , polycyclic aromatic hydrocarbons ( PAHs ) are a severe concern because of their carcinogenic and mutagenic properties .',
  'Atmospheric pollution by polycyclic aromatic hydrocarbons ( PAHs ) has become a serious problem , especially in Asia , as PAHs can severely affect ecologically important mountainous areas .'],
 'hydrocarbons': ['Exposure to trace metals and polycyclic aromatic hydrocarbons ( PAHs ) adsorbed on particulates is of a serious health concern .',
  'Polycyclic aromatic hydrocarbons ( PAHs ) in street dust pose a serious problem threatening both the environment and human health .',
  'Contamination of polycyclic aromatic hydrocarbons ( PAHs ) in environment indicates a serious problem to the present era .',
  'Halogenations of polycyclic aromatic hydrocarbons ( PAHs ) comprise a serious problem , when electrochemical oxidation ( EO ) is applied for treatment of chloride and bromide containing polluted sea water .',
  'However , as environmental PAH concentrations build up , this may be a serious concern around the incinerator vicinity due to the potential consequences of PAHs on ecosystems and human health .',
  'Chlorinated polycyclic aromatic hydrocarbons ( ClPAHs ) have become a serious environmental concern due to their widespread occurrence and dioxin-like toxicities .',
  'Contamination of soils with polycyclic aromatic hydrocarbons ( PAHs ) is a serious problem in petroleum producing countries , such as México , and environment-friendly easy to apply techniques are required to accelerate the removal of the contaminants .',
  'Nowadays , contamination by polycyclic aromatic hydrocarbons ( PAHs ) has become a serious problem all over the world ; in particular , high-molecular-weight PAHs ( HWM PAHs , four to seven rings ) are more harmful to human health and environment due to their more complex structure and metabolic pathway .',
  'Polycyclic aromatic hydrocarbons ( PAHs ) pollution in urban river sediments is a serious problem to ecological systems and human health .',
  'PCB contamination of indoor air in public buildings by elastic sealants has proved to be a serious problem in West Berlin .',
  'Soil contamination with polycyclic aromatic hydrocarbons ( PAHs ) is a serious problem in Northeast China , especially in the steel industrial area .',
  'The intensive production of polycyclic aromatic hydrocarbons by anthropogenic activities is a serious environmental problem .',
  'Bioremediation of surface waters contaminated with polycyclic aromatic hydrocarbons ( PAHs ) is a serious problem , often limited by the low bioavailability of contaminants as a result of their low aqueous solubility .',
  'Nowadays , contamination of soil and marine sediments by polycyclic aromatic hydrocarbons ( PAHs ) has become a serious problem all over the world .',
  'Among the pollutants emitted , polycyclic aromatic hydrocarbons ( PAHs ) are a severe concern because of their carcinogenic and mutagenic properties .',
  'Atmospheric pollution by polycyclic aromatic hydrocarbons ( PAHs ) has become a serious problem , especially in Asia , as PAHs can severely affect ecologically important mountainous areas .'],
 'cholera': ['For example : ( i ) a child dies in Africa every 30s due to malaria-a disease related to stagnant water , ( ii ) every year flooding causes many deaths world-wide , with infant mortality due to diarrhea from contaminated flood waters posing the biggest threat , and ( iii ) poor sanitation and its relation to hepatitis A continues to be a serious problem .',
  'Cholera remains a serious health problem , especially in developing countries where basic hygiene standards are not met .',
  'In 1985 cholera has been a serious problem in the horn of Africa , particularly affecting the many famine victims and refugees in that region .',
  'Globally , there is a lack of information on water contamination , occurrence of diarrhoea and antibiotic resistance , a serious global concern , in relation to IWMP in hilly tribal areas .',
  'However , the sanitary problems related to sewage treatment and the existence of cholera in other South American countries poses a serious problem for the future .',
  'Cholera , a life-threatening disease caused by the Gram-negative bacterium Vibrio cholera , remains a concern in developing countries .',
  'Cholera , though a preventable and treatable disease , is still regarded as an important public health problem in developing countries including India .',
  'Cholera is a serious epidemic disease that has killed millions of people and continues to be a major health problem world-wide .',
  'Cholera is still a serious public health problem in developing countries , particularly those in tropical regions .',
  'Cholera continues to be a serious public health concern in developing countries and the global increase in the number of reported outbreaks suggests that activities to control the diseases and surveillance programs to identify or predict the occurrence of the next outbreaks are not adequate .',
  'Cholera continued to be a major diarrheal illness in Nepal and antibiotic resistance has appeared as a serious problem in cholera management .',
  'Vibrio cholerae is a serious public health problem worldwide , but in the UK , V. cholerae infections are rare .',
  'Sanitation was a serious problem , e.g. fewer than 5 % of villagers used latrines and 18 % of under-5-year-olds had suffered a recent diarrhoeal illness .',
  'Through the proposed strategy , it becomes possible to improve the specificity and sensitivity of these systems and to reduce the cost of making a diagnosis , thus making them suitable for use in cholera surveillance in low-income settings where this disease is a serious public health problem .',
  'Recognition of unconsciousness as a serious sign of dehydration and concern that cholera outbreaks would overwhelm the local healthcare system in the rural area were positive determinants of acceptance .',
  'It also supplies data to international surveillance networks for cholera , which remains a serious disease and a major problem globally .'],
 'ptsd': ['Post-traumatic stress disorder ( PTSD ) is a serious problem not only among workers who experience industrial accidents but also among workers who witness such accidents .',
  'Posttraumatic stress disorder ( PTSD ) is a severe problem among soldiers with combating experience difficult to treat .',
  'Veteran populations are exposed to multiple stressful events , and suicidality among veterans is a serious problem .',
  'Posttraumatic stress disorder ( PTSD ) is a serious mental health concern for returning U.S. military personnel who have a higher prevalence rate of PTSD than the general population .',
  'Mental health issues are a serious concern for many American Indian Veterans , especially for post-traumatic stress disorder and related psychiatric conditions .',
  'Posttraumatic stress disorder ( PTSD ) is a serious and global problem , a psychiatric disorder that frequently occurs with different comorbidities , and is associated with a high suicide rate .',
  'Post Traumatic Stress Disorder ( PTSD ) can be a debilitating problem in service members who have served in Iraq or Afghanistan .',
  'While post-traumatic stress disorder ( PTSD ) and other trauma- and stress-related disorders ( TSRDs ) represent a serious societal and public health concern , their pathogenesis is largely unknown .',
  'In multivariate analysis , PTSD was positively associated with the perception of stress as a serious problem ( OR \u2009 = \u2009 6.52 ; P-value \u2009 = \u2009 0.003 ) , safety and protection for women in the community ( OR \u2009 = \u2009 2.35 ; P-value \u2009 = \u2009 0.011 ) , care for family ( OR \u2009 = \u2009 2.00 ; P-value \u2009 = \u2009 0.035 ) and Place to live in ( OR \u2009 = \u2009 1.83 ; P-value \u2009 = \u2009 0.04 ) .',
  'Depression is a serious problem among military personnel returning from combat deployments , and is related to a range of adverse outcomes including alcohol and drug abuse , family violence and suicide .',
  'Posttraumatic stress disorder ( PTSD ) is a debilitating trauma and stressor-related disorder that has become a major neuropsychiatric problem , leading to substantial disruptions in individual health and societal costs .',
  'Just as traumatic experiences may lead to posttraumatic stress disorder ( PTSD ) in some individuals , grief may also be a serious health concern for individuals who have experienced bereavement .',
  'This could be a serious problem for military or emergency personnel recalled to combat or a disaster site without sufficient time to deal with the effects of their initial experiences .',
  'Post-traumatic stress disorder ( PTSD ) is increasingly becoming recognised as a serious mental health problem ( Department of Health , 1991 ) .',
  'PTSD represents a serious mental health problem after a disaster .',
  'Although PTSD may be a serious problem in some survivors of critical illness , data on the whole population are inconclusive .',
  'Posttraumatic stress disorder ( PTSD ) is a serious health concern .',
  'PTSD is a serious public health concern , which compels the search for novel paradigms and theoretical models to deepen the understanding of the condition and to develop new and improved modes of treatment intervention .',
  'Benzodiazepines and selective serotonin reuptake inhibitors ( SSRIs ) are considered the gold standard for PTSD treatment , but their side effects pose a serious problem .'],
 'posttraumatic': ['Post-traumatic stress disorder ( PTSD ) is a serious problem not only among workers who experience industrial accidents but also among workers who witness such accidents .',
  'Posttraumatic stress disorder ( PTSD ) is a severe problem among soldiers with combating experience difficult to treat .',
  'Veteran populations are exposed to multiple stressful events , and suicidality among veterans is a serious problem .',
  'Posttraumatic stress disorder ( PTSD ) is a serious mental health concern for returning U.S. military personnel who have a higher prevalence rate of PTSD than the general population .',
  'Mental health issues are a serious concern for many American Indian Veterans , especially for post-traumatic stress disorder and related psychiatric conditions .',
  'Posttraumatic stress disorder ( PTSD ) is a serious and global problem , a psychiatric disorder that frequently occurs with different comorbidities , and is associated with a high suicide rate .',
  'Post Traumatic Stress Disorder ( PTSD ) can be a debilitating problem in service members who have served in Iraq or Afghanistan .',
  'While post-traumatic stress disorder ( PTSD ) and other trauma- and stress-related disorders ( TSRDs ) represent a serious societal and public health concern , their pathogenesis is largely unknown .',
  'In multivariate analysis , PTSD was positively associated with the perception of stress as a serious problem ( OR \u2009 = \u2009 6.52 ; P-value \u2009 = \u2009 0.003 ) , safety and protection for women in the community ( OR \u2009 = \u2009 2.35 ; P-value \u2009 = \u2009 0.011 ) , care for family ( OR \u2009 = \u2009 2.00 ; P-value \u2009 = \u2009 0.035 ) and Place to live in ( OR \u2009 = \u2009 1.83 ; P-value \u2009 = \u2009 0.04 ) .',
  'Depression is a serious problem among military personnel returning from combat deployments , and is related to a range of adverse outcomes including alcohol and drug abuse , family violence and suicide .',
  'Posttraumatic stress disorder ( PTSD ) is a debilitating trauma and stressor-related disorder that has become a major neuropsychiatric problem , leading to substantial disruptions in individual health and societal costs .',
  'Just as traumatic experiences may lead to posttraumatic stress disorder ( PTSD ) in some individuals , grief may also be a serious health concern for individuals who have experienced bereavement .',
  'This could be a serious problem for military or emergency personnel recalled to combat or a disaster site without sufficient time to deal with the effects of their initial experiences .',
  'Post-traumatic stress disorder ( PTSD ) is increasingly becoming recognised as a serious mental health problem ( Department of Health , 1991 ) .',
  'PTSD represents a serious mental health problem after a disaster .',
  'Although PTSD may be a serious problem in some survivors of critical illness , data on the whole population are inconclusive .',
  'Posttraumatic stress disorder ( PTSD ) is a serious health concern .',
  'PTSD is a serious public health concern , which compels the search for novel paradigms and theoretical models to deepen the understanding of the condition and to develop new and improved modes of treatment intervention .',
  'Benzodiazepines and selective serotonin reuptake inhibitors ( SSRIs ) are considered the gold standard for PTSD treatment , but their side effects pose a serious problem .'],
 'transfusion': ['Transfusion-related bacterial contamination is a serious problem .',
  'However , because of transfusion-induced infectious diseases , the safety of serum products is a serious concern .',
  'Red blood cell immunization is a serious problem in transfused patients .',
  'Errors prevention and patient safety in transfusion medicine are a serious concern .',
  'Despite donor selection and screening procedures , the transmission of viruses by blood and blood products remains a serious problem .',
  'However , plasma exchange needs fresh frozen plasma or another protein fraction from humans , and virus contamination or other infectious factors are a serious problem .',
  'Bacterial contamination of platelet concentrates ( PCs ) remains a serious problem in transfusion .',
  'Transfusion-transmissible infections , human immunodeficiency virus , hepatitis B virus , hepatitis C virus , and syphilis are among the greatest threats to blood safety and pose a serious public health problem .',
  '[ Post-transfusion hepatitis : a serious problem ] .',
  'Post-transfusion hepatitis , a serious clinical problem .',
  'Chronic red blood cell exchanges ( RBCXs ) are frequently used to prevent complications in patients with sickle cell anemia , but the scarcity of matched red blood cell packs ( RBCPs ) is a serious concern .',
  'Management of a severe transfusional problem in a patient with alloantibody to Kpb ( K4 ) .',
  'Such feature was attributed to the lower affinity for O2 of HbXL99 alpha and may represent a serious problem for use of this Hb as blood substitute .',
  'Red cell alloimmunization is a serious problem that could potentially affect 50 % of transfused patients .',
  'Transfusion-transmissible infections such as hepatitis B and hepatitis C are among the greatest threats to blood safety for transfusion recipients and pose a serious public health problem .',
  'Transfusion-transmissible infectious agents such as hepatitis B virus ( HBV ) , human immunodeficiency virus ( HIV ) , hepatitis C virus ( HCV ) and syphilis are among the greatest threats to blood safety for transfusion recipients and pose a serious public health problem .',
  'However since this effect is reversed when DEHP administration is stopped , it may not be a serious problem in the case of a few transfusion ; but in patients receiving repeated blood transfusion as in thalassemia patients or patients undergoing hemodialysis , possibility of this risk has to be considered .',
  'Protecting the blood supply from emerging infectious threats remains a serious concern in the transfusion medicine community .',
  'Red cell alloimmunization is a serious problem in chronically transfused patients .',
  'Transfusion transmitted hepatitis has been a severe problem in Turkey in pediatric cancer patients and in chronic congenital anemia .',
  'Generation of alloantibodies to transfused RBCs can be a serious medical problem for patients who require chronic RBC transfusion therapy .',
  'Patients with severe anemia , allo- and autoantibodies , either showing hemolysis in their pathophysiology or not , cause a serious problem in any transfusion center , especially when dealing with emergencies .'],
 'transfused': ['Transfusion-related bacterial contamination is a serious problem .',
  'However , because of transfusion-induced infectious diseases , the safety of serum products is a serious concern .',
  'Red blood cell immunization is a serious problem in transfused patients .',
  'Errors prevention and patient safety in transfusion medicine are a serious concern .',
  'Despite donor selection and screening procedures , the transmission of viruses by blood and blood products remains a serious problem .',
  'However , plasma exchange needs fresh frozen plasma or another protein fraction from humans , and virus contamination or other infectious factors are a serious problem .',
  'Bacterial contamination of platelet concentrates ( PCs ) remains a serious problem in transfusion .',
  'Transfusion-transmissible infections , human immunodeficiency virus , hepatitis B virus , hepatitis C virus , and syphilis are among the greatest threats to blood safety and pose a serious public health problem .',
  '[ Post-transfusion hepatitis : a serious problem ] .',
  'Post-transfusion hepatitis , a serious clinical problem .',
  'Chronic red blood cell exchanges ( RBCXs ) are frequently used to prevent complications in patients with sickle cell anemia , but the scarcity of matched red blood cell packs ( RBCPs ) is a serious concern .',
  'Management of a severe transfusional problem in a patient with alloantibody to Kpb ( K4 ) .',
  'Such feature was attributed to the lower affinity for O2 of HbXL99 alpha and may represent a serious problem for use of this Hb as blood substitute .',
  'Red cell alloimmunization is a serious problem that could potentially affect 50 % of transfused patients .',
  'Transfusion-transmissible infections such as hepatitis B and hepatitis C are among the greatest threats to blood safety for transfusion recipients and pose a serious public health problem .',
  'Transfusion-transmissible infectious agents such as hepatitis B virus ( HBV ) , human immunodeficiency virus ( HIV ) , hepatitis C virus ( HCV ) and syphilis are among the greatest threats to blood safety for transfusion recipients and pose a serious public health problem .',
  'However since this effect is reversed when DEHP administration is stopped , it may not be a serious problem in the case of a few transfusion ; but in patients receiving repeated blood transfusion as in thalassemia patients or patients undergoing hemodialysis , possibility of this risk has to be considered .',
  'Protecting the blood supply from emerging infectious threats remains a serious concern in the transfusion medicine community .',
  'Red cell alloimmunization is a serious problem in chronically transfused patients .',
  'Transfusion transmitted hepatitis has been a severe problem in Turkey in pediatric cancer patients and in chronic congenital anemia .',
  'Generation of alloantibodies to transfused RBCs can be a serious medical problem for patients who require chronic RBC transfusion therapy .',
  'Patients with severe anemia , allo- and autoantibodies , either showing hemolysis in their pathophysiology or not , cause a serious problem in any transfusion center , especially when dealing with emergencies .'],
 'blood': ['Transfusion-related bacterial contamination is a serious problem .',
  'However , because of transfusion-induced infectious diseases , the safety of serum products is a serious concern .',
  'Red blood cell immunization is a serious problem in transfused patients .',
  'Errors prevention and patient safety in transfusion medicine are a serious concern .',
  'Despite donor selection and screening procedures , the transmission of viruses by blood and blood products remains a serious problem .',
  'However , plasma exchange needs fresh frozen plasma or another protein fraction from humans , and virus contamination or other infectious factors are a serious problem .',
  'Bacterial contamination of platelet concentrates ( PCs ) remains a serious problem in transfusion .',
  'Transfusion-transmissible infections , human immunodeficiency virus , hepatitis B virus , hepatitis C virus , and syphilis are among the greatest threats to blood safety and pose a serious public health problem .',
  '[ Post-transfusion hepatitis : a serious problem ] .',
  'Post-transfusion hepatitis , a serious clinical problem .',
  'Chronic red blood cell exchanges ( RBCXs ) are frequently used to prevent complications in patients with sickle cell anemia , but the scarcity of matched red blood cell packs ( RBCPs ) is a serious concern .',
  'Management of a severe transfusional problem in a patient with alloantibody to Kpb ( K4 ) .',
  'Such feature was attributed to the lower affinity for O2 of HbXL99 alpha and may represent a serious problem for use of this Hb as blood substitute .',
  'Red cell alloimmunization is a serious problem that could potentially affect 50 % of transfused patients .',
  'Transfusion-transmissible infections such as hepatitis B and hepatitis C are among the greatest threats to blood safety for transfusion recipients and pose a serious public health problem .',
  'Transfusion-transmissible infectious agents such as hepatitis B virus ( HBV ) , human immunodeficiency virus ( HIV ) , hepatitis C virus ( HCV ) and syphilis are among the greatest threats to blood safety for transfusion recipients and pose a serious public health problem .',
  'However since this effect is reversed when DEHP administration is stopped , it may not be a serious problem in the case of a few transfusion ; but in patients receiving repeated blood transfusion as in thalassemia patients or patients undergoing hemodialysis , possibility of this risk has to be considered .',
  'Protecting the blood supply from emerging infectious threats remains a serious concern in the transfusion medicine community .',
  'Red cell alloimmunization is a serious problem in chronically transfused patients .',
  'Transfusion transmitted hepatitis has been a severe problem in Turkey in pediatric cancer patients and in chronic congenital anemia .',
  'Generation of alloantibodies to transfused RBCs can be a serious medical problem for patients who require chronic RBC transfusion therapy .',
  'Patients with severe anemia , allo- and autoantibodies , either showing hemolysis in their pathophysiology or not , cause a serious problem in any transfusion center , especially when dealing with emergencies .'],
 'ward': ['This is a serious problem , because the LTCI service requirement certification is equivalent to disability .',
  'This is a serious problem which pervades community , acute and chronic care settings .',
  'Repeated hospital admission is a serious problem for both the patient and the health care system .',
  'Waiting times for elective care have been considered a serious problem in many health care systems .',
  'It is a challenge to physicians , a serious problem to patients and a human and financial loss to the community .',
  'These " deinstitutionalized " patients cause a serious problem for the Health system .',
  'Providers need to prepare now for what is apt to be a serious financial , organizational , and emotional problem .',
  'These behaviors are a serious , growing problem , which affects a significant proportion of health care professionals .',
  'M.R.S.A. has become a serious problem in many hospitals since the mid 1970s .',
  'Yet over half of respondents working on a palliative care unit ( 87 % , n=15 ) , traumatological ward ( 67 % , n=18 ) , cardio-thoracic surgery ward ( 58 % , n=20 ) , intensive care unit ( 55 % , n=120 ) and geriatric ward ( 55 % , n=42 ) reported it as a serious problem .',
  'Although pre-hospital delay is a serious problem in both women and men , women appear to delay substantially longer than men .',
  'This is a serious concern , as the burden of steering individuals with SUDs into treatment often falls to criminal defense attorneys .',
  'This is becoming to be a serious global problem , particularly in hospitals .',
  'This is not only a devastating problem for the family , but a very expensive problem as well .',
  'The main reasons seeking care late were : the woman or her family not perceiving that there was a serious problem , distance to health facility , and lack of transport .',
  'CE represents a serious concern for both public health services and the society , mainly because of prolonged hospitalization and convalescence periods .'],
 'cysticercosis': ['Cysticercosis is an emerging and neglected tropical disease ( NTD ) that poses a serious public health concern worldwide .',
  'Cysticercosis is a severe public health problem in several regions of Asia , Africa and Latin America .',
  'Neurocysticercosis ( NC ) is a serious public health problem mainly in developing countries .',
  'Taenia solium cysticercosis is still a serious public health problem in several countries where poverty and lack of hygiene favor transmission .',
  'Oculomycosis is a severe problem in most developing countries .',
  'Taenia solium cysticercosis/taeniosis is emerging as a serious public health and economic problem in many developing countries .',
  'We conclude that Campina Grande has to be included as an endemic area of neurocysticercosis , needing health service measures to cease the cycle Taenia-Cysticercus , the only way to get rid of such a serious problem .',
  'The pork tapeworm , Taenia solium , is a serious public health problem in rural low-resource areas of Latin America , Africa and Asia , where the associated conditions of nuerocysticercosis ( NCC ) and porcine cysticercosis cause substantial health and economic harms .',
  'Neurocysticercosis is a serious public health concern in northern Tanzania .',
  'Human neurocysticercosis - often a life-threatening disease - is increasingly recognized as a public health problem , especially in developing countries .',
  'aeniasis-cysticercosis may be a serious health problem in some areas of Honduras .',
  'Neurocysticercosis is a serious public health problem in several countries of Asia , Africa and Latin America .',
  'Cysticercosis of visual system is a serious clinical problem .',
  'Hydrocephalus is a serious complication of cranial coccidioidomycosis , and the surgical management of coccidioidomycosis-related hydrocephalus has unique challenges .',
  'Neurocysticercosis ( NC ) is a serious public health problem in Taenia solium endemic areas and in some immigrants and international travelers .',
  'Cysticercosis is a serious public health problem in Madagascar .',
  'Overall , this study shows that cysticercosis is relatively common and potentially a serious health problem in this region .',
  'The emergence of Taenia solium cysticercosis in Eastern and Southern Africa as a serious agricultural problem and public health risk .',
  'Cysticercosis is emerging as a serious public health and agricultural problem in many poorer countries of Latin America , Africa , and Asia .',
  'Neurocysticercosis ( NC ) caused by Taenia solium metacestode ( TsM ) is a serious neurological disease of global concern .',
  'Neurocysticercosis is a serious public health problem in our midst , which accounted for 7.3 % of the hospital admissions and 2.7 % of all cases of the out patient clinic attendance of the Discipline of Neurology of the School of Medicine -- Ribeirão Preto , São Paulo University , from 1979 to 1986 .',
  'Hospital surveys indicate that cysticercosis is emerging as a serious health problem in the country though most of the information comes from the Hanoi area .',
  'Cysticercosis due to larval cysts of Taenia solium , is a serious public health problem affecting humans in numerous regions worldwide .',
  'A survey of 100 rural households in a village in the Chaco region of Bolivia revealed a serious problem of Taenia solium cysticercosis , with a seroprevalence of 99/447 ( 22 % ) in humans and 102/273 ( 37 % ) in pigs .',
  'Neurocysticercosis is a serious public health problem that predominantly affects places with poor sanitary and hygiene conditions .',
  'Cysticercosis commonly affects the central nervous system and other tissues by dissemination imposing a serious health problem .',
  'Cysticercosis is the most common parasite affecting the central nervous system and is a serious health problem in many parts of the world .',
  'Neurocysticercosis ( NCC ) is an important neurological disease in countries with high prevalence of Taenia solium infection and is emerging as a serious public health and economic problem .'],
 'taenia': ['Cysticercosis is an emerging and neglected tropical disease ( NTD ) that poses a serious public health concern worldwide .',
  'Cysticercosis is a severe public health problem in several regions of Asia , Africa and Latin America .',
  'Neurocysticercosis ( NC ) is a serious public health problem mainly in developing countries .',
  'Taenia solium cysticercosis is still a serious public health problem in several countries where poverty and lack of hygiene favor transmission .',
  'Oculomycosis is a severe problem in most developing countries .',
  'Taenia solium cysticercosis/taeniosis is emerging as a serious public health and economic problem in many developing countries .',
  'We conclude that Campina Grande has to be included as an endemic area of neurocysticercosis , needing health service measures to cease the cycle Taenia-Cysticercus , the only way to get rid of such a serious problem .',
  'The pork tapeworm , Taenia solium , is a serious public health problem in rural low-resource areas of Latin America , Africa and Asia , where the associated conditions of nuerocysticercosis ( NCC ) and porcine cysticercosis cause substantial health and economic harms .',
  'Neurocysticercosis is a serious public health concern in northern Tanzania .',
  'Human neurocysticercosis - often a life-threatening disease - is increasingly recognized as a public health problem , especially in developing countries .',
  'aeniasis-cysticercosis may be a serious health problem in some areas of Honduras .',
  'Neurocysticercosis is a serious public health problem in several countries of Asia , Africa and Latin America .',
  'Cysticercosis of visual system is a serious clinical problem .',
  'Hydrocephalus is a serious complication of cranial coccidioidomycosis , and the surgical management of coccidioidomycosis-related hydrocephalus has unique challenges .',
  'Neurocysticercosis ( NC ) is a serious public health problem in Taenia solium endemic areas and in some immigrants and international travelers .',
  'Cysticercosis is a serious public health problem in Madagascar .',
  'Overall , this study shows that cysticercosis is relatively common and potentially a serious health problem in this region .',
  'The emergence of Taenia solium cysticercosis in Eastern and Southern Africa as a serious agricultural problem and public health risk .',
  'Cysticercosis is emerging as a serious public health and agricultural problem in many poorer countries of Latin America , Africa , and Asia .',
  'Neurocysticercosis ( NC ) caused by Taenia solium metacestode ( TsM ) is a serious neurological disease of global concern .',
  'Neurocysticercosis is a serious public health problem in our midst , which accounted for 7.3 % of the hospital admissions and 2.7 % of all cases of the out patient clinic attendance of the Discipline of Neurology of the School of Medicine -- Ribeirão Preto , São Paulo University , from 1979 to 1986 .',
  'Hospital surveys indicate that cysticercosis is emerging as a serious health problem in the country though most of the information comes from the Hanoi area .',
  'Cysticercosis due to larval cysts of Taenia solium , is a serious public health problem affecting humans in numerous regions worldwide .',
  'A survey of 100 rural households in a village in the Chaco region of Bolivia revealed a serious problem of Taenia solium cysticercosis , with a seroprevalence of 99/447 ( 22 % ) in humans and 102/273 ( 37 % ) in pigs .',
  'Neurocysticercosis is a serious public health problem that predominantly affects places with poor sanitary and hygiene conditions .',
  'Cysticercosis commonly affects the central nervous system and other tissues by dissemination imposing a serious health problem .',
  'Cysticercosis is the most common parasite affecting the central nervous system and is a serious health problem in many parts of the world .',
  'Neurocysticercosis ( NCC ) is an important neurological disease in countries with high prevalence of Taenia solium infection and is emerging as a serious public health and economic problem .'],
 'neurocysticercosis': ['Cysticercosis is an emerging and neglected tropical disease ( NTD ) that poses a serious public health concern worldwide .',
  'Cysticercosis is a severe public health problem in several regions of Asia , Africa and Latin America .',
  'Neurocysticercosis ( NC ) is a serious public health problem mainly in developing countries .',
  'Taenia solium cysticercosis is still a serious public health problem in several countries where poverty and lack of hygiene favor transmission .',
  'Oculomycosis is a severe problem in most developing countries .',
  'Taenia solium cysticercosis/taeniosis is emerging as a serious public health and economic problem in many developing countries .',
  'We conclude that Campina Grande has to be included as an endemic area of neurocysticercosis , needing health service measures to cease the cycle Taenia-Cysticercus , the only way to get rid of such a serious problem .',
  'The pork tapeworm , Taenia solium , is a serious public health problem in rural low-resource areas of Latin America , Africa and Asia , where the associated conditions of nuerocysticercosis ( NCC ) and porcine cysticercosis cause substantial health and economic harms .',
  'Neurocysticercosis is a serious public health concern in northern Tanzania .',
  'Human neurocysticercosis - often a life-threatening disease - is increasingly recognized as a public health problem , especially in developing countries .',
  'aeniasis-cysticercosis may be a serious health problem in some areas of Honduras .',
  'Neurocysticercosis is a serious public health problem in several countries of Asia , Africa and Latin America .',
  'Cysticercosis of visual system is a serious clinical problem .',
  'Hydrocephalus is a serious complication of cranial coccidioidomycosis , and the surgical management of coccidioidomycosis-related hydrocephalus has unique challenges .',
  'Neurocysticercosis ( NC ) is a serious public health problem in Taenia solium endemic areas and in some immigrants and international travelers .',
  'Cysticercosis is a serious public health problem in Madagascar .',
  'Overall , this study shows that cysticercosis is relatively common and potentially a serious health problem in this region .',
  'The emergence of Taenia solium cysticercosis in Eastern and Southern Africa as a serious agricultural problem and public health risk .',
  'Cysticercosis is emerging as a serious public health and agricultural problem in many poorer countries of Latin America , Africa , and Asia .',
  'Neurocysticercosis ( NC ) caused by Taenia solium metacestode ( TsM ) is a serious neurological disease of global concern .',
  'Neurocysticercosis is a serious public health problem in our midst , which accounted for 7.3 % of the hospital admissions and 2.7 % of all cases of the out patient clinic attendance of the Discipline of Neurology of the School of Medicine -- Ribeirão Preto , São Paulo University , from 1979 to 1986 .',
  'Hospital surveys indicate that cysticercosis is emerging as a serious health problem in the country though most of the information comes from the Hanoi area .',
  'Cysticercosis due to larval cysts of Taenia solium , is a serious public health problem affecting humans in numerous regions worldwide .',
  'A survey of 100 rural households in a village in the Chaco region of Bolivia revealed a serious problem of Taenia solium cysticercosis , with a seroprevalence of 99/447 ( 22 % ) in humans and 102/273 ( 37 % ) in pigs .',
  'Neurocysticercosis is a serious public health problem that predominantly affects places with poor sanitary and hygiene conditions .',
  'Cysticercosis commonly affects the central nervous system and other tissues by dissemination imposing a serious health problem .',
  'Cysticercosis is the most common parasite affecting the central nervous system and is a serious health problem in many parts of the world .',
  'Neurocysticercosis ( NCC ) is an important neurological disease in countries with high prevalence of Taenia solium infection and is emerging as a serious public health and economic problem .'],
 'drowning': ['Childhood drowning remains a serious public health problem worldwide .',
  'Accidental drowning of children under five is a serious problem in China .',
  'Drowning is a serious worldwide , mostly preventable injury problem , particularly among international travelers .',
  'Drowning remains a serious problem , particularly for the 1 - 4 year olds .',
  "Is drowning a serious public health problem in Guangdong Province , People 's Republic of China ?-- results from a retrospective population-based survey , 2004 - 2005 .",
  'Drowning , which typically involves a watery environment , remains a serious public health concern claiming an estimated 362 000 lives per year worldwide across all socioeconomic classifications and has remained under close observation by the World Health Organization and its signatories .',
  'Drowning is a serious public health problem in Florida .',
  '[ Death by drowning , a serious population-political problem ] .',
  'Drowning was a severe problem for boys and girls younger than 5 years .',
  'Drowning is the third leading cause of death for children aged 0 - 4 years in many Asian countries , and is a serious but neglected health problem in low and middle-income countries like Bangladesh .',
  'Drowning is a serious but neglected health problem in low-and middle-income countries .',
  'Drowning deaths are a serious and preventable public health problem worldwide .'],
 'iodine': ['Our study shows that iodine deficiency is a serious problem among pregnant women in Edirne .',
  'Iodine deficiency disorders ( IDD ) constitute a severe public health problem in Sudan .',
  'Our study revealed that iodine deficiency still remains a serious problem for pregnant women .',
  'Iodine deficiency is a serious public health problem worldwide which is associated with mental retardation and cretinism .',
  'However , iodine malnutrition is still a severe public health problem because some communities in this study such as in Kisoro still have low iodine consumption , while others such as Luwero now have iodine excess .',
  'Iodine-deficiency disorders have been a serious public health problem in Brazil because of the failure of a salt iodination programme established in 1953 .',
  'The study demonstrated that iodine deficiency is still a severe public health problem in Metekel Zone .',
  'Iodine deficiency has been recognized as a severe public health concern in Ethiopia , however little is known about the problem .',
  'Elevated iodine intake is a serious problem in the diagnostic and therapeutic application of (131)iodine in patients with differentiated thyroid cancer .',
  'Chronic iodine deficiency was a severe public health problem in the study communities .',
  'Our study shows that iodine deficiency is a serious problem among pregnant women in Ankara .',
  'The environmental iodine deficiency has been a serious problem in the Polish health care system for many years .',
  'Iodine deficiency in Israeli SAC and PW is a serious public-health concern .',
  'The-findings of the present study indicated that as per clinical criteria of WHO/UNICEF/ICCIDD , IDD is a severe public health problem though apparently there is no biochemical iodine deficiency .',
  'In general , the study revealed that iodine deficiency disorder was a serious public health concern .',
  'Iodine deficiency disorders ( IDD ) are a serious public-health problem in Bangladesh and in other countries .',
  'Our results indicate that although Isparta is a region with mild iodine deficiency , goiter prevalence remains a serious problem .',
  'Although large-scale salt iodination began long time ago , iodine deficiency is still a serious health problem among pregnant women .',
  'Iodine deficiency disorders continue to be a severe problem in many parts of Central Asia , causing delayed mental development and cretinism in indigenous populations .',
  'This study is the first to show borderline iodine sufficiency in reproductive age Saudi women from the Western province , whereas mild iodine deficiency was observed in the pregnant population and could represent a serious public health problem .'],
 'pregnant': ['Our study shows that iodine deficiency is a serious problem among pregnant women in Edirne .',
  'Iodine deficiency disorders ( IDD ) constitute a severe public health problem in Sudan .',
  'Our study revealed that iodine deficiency still remains a serious problem for pregnant women .',
  'Iodine deficiency is a serious public health problem worldwide which is associated with mental retardation and cretinism .',
  'However , iodine malnutrition is still a severe public health problem because some communities in this study such as in Kisoro still have low iodine consumption , while others such as Luwero now have iodine excess .',
  'Iodine-deficiency disorders have been a serious public health problem in Brazil because of the failure of a salt iodination programme established in 1953 .',
  'The study demonstrated that iodine deficiency is still a severe public health problem in Metekel Zone .',
  'Iodine deficiency has been recognized as a severe public health concern in Ethiopia , however little is known about the problem .',
  'Elevated iodine intake is a serious problem in the diagnostic and therapeutic application of (131)iodine in patients with differentiated thyroid cancer .',
  'Chronic iodine deficiency was a severe public health problem in the study communities .',
  'Our study shows that iodine deficiency is a serious problem among pregnant women in Ankara .',
  'The environmental iodine deficiency has been a serious problem in the Polish health care system for many years .',
  'Iodine deficiency in Israeli SAC and PW is a serious public-health concern .',
  'The-findings of the present study indicated that as per clinical criteria of WHO/UNICEF/ICCIDD , IDD is a severe public health problem though apparently there is no biochemical iodine deficiency .',
  'In general , the study revealed that iodine deficiency disorder was a serious public health concern .',
  'Iodine deficiency disorders ( IDD ) are a serious public-health problem in Bangladesh and in other countries .',
  'Our results indicate that although Isparta is a region with mild iodine deficiency , goiter prevalence remains a serious problem .',
  'Although large-scale salt iodination began long time ago , iodine deficiency is still a serious health problem among pregnant women .',
  'Iodine deficiency disorders continue to be a severe problem in many parts of Central Asia , causing delayed mental development and cretinism in indigenous populations .',
  'This study is the first to show borderline iodine sufficiency in reproductive age Saudi women from the Western province , whereas mild iodine deficiency was observed in the pregnant population and could represent a serious public health problem .'],
 'idd': ['Our study shows that iodine deficiency is a serious problem among pregnant women in Edirne .',
  'Iodine deficiency disorders ( IDD ) constitute a severe public health problem in Sudan .',
  'Our study revealed that iodine deficiency still remains a serious problem for pregnant women .',
  'Iodine deficiency is a serious public health problem worldwide which is associated with mental retardation and cretinism .',
  'However , iodine malnutrition is still a severe public health problem because some communities in this study such as in Kisoro still have low iodine consumption , while others such as Luwero now have iodine excess .',
  'Iodine-deficiency disorders have been a serious public health problem in Brazil because of the failure of a salt iodination programme established in 1953 .',
  'The study demonstrated that iodine deficiency is still a severe public health problem in Metekel Zone .',
  'Iodine deficiency has been recognized as a severe public health concern in Ethiopia , however little is known about the problem .',
  'Elevated iodine intake is a serious problem in the diagnostic and therapeutic application of (131)iodine in patients with differentiated thyroid cancer .',
  'Chronic iodine deficiency was a severe public health problem in the study communities .',
  'Our study shows that iodine deficiency is a serious problem among pregnant women in Ankara .',
  'The environmental iodine deficiency has been a serious problem in the Polish health care system for many years .',
  'Iodine deficiency in Israeli SAC and PW is a serious public-health concern .',
  'The-findings of the present study indicated that as per clinical criteria of WHO/UNICEF/ICCIDD , IDD is a severe public health problem though apparently there is no biochemical iodine deficiency .',
  'In general , the study revealed that iodine deficiency disorder was a serious public health concern .',
  'Iodine deficiency disorders ( IDD ) are a serious public-health problem in Bangladesh and in other countries .',
  'Our results indicate that although Isparta is a region with mild iodine deficiency , goiter prevalence remains a serious problem .',
  'Although large-scale salt iodination began long time ago , iodine deficiency is still a serious health problem among pregnant women .',
  'Iodine deficiency disorders continue to be a severe problem in many parts of Central Asia , causing delayed mental development and cretinism in indigenous populations .',
  'This study is the first to show borderline iodine sufficiency in reproductive age Saudi women from the Western province , whereas mild iodine deficiency was observed in the pregnant population and could represent a serious public health problem .'],
 'typhoid': ['Scrub typhus ( ST ) has emerged as a serious public health problem in India .',
  'The results of the current study enhance the belief that murine typhus is a serious public health problem in Cyprus .',
  'Typhoid fever remains a serious problem in developing countries .',
  'Paratyphoid fever caused by Salmonella Paratyphi A is a serious public health problem in many countries .',
  'Typhoid perforation ileitis is a serious complication of typhoid fever , a common and unfortunate health problem in a resource-poor country like Nigeria .',
  'Typhoid fever remains a serious problem in many developing countries .',
  'Typhoid fever remains a serious public health problem .',
  'Typhoid fever , caused by the pathogen Salmonella enterica serovar Typhi ( S. Typhi ) , is a serious global health concern .',
  'In conclusion drug resistant typhoid fever will become a serious problem in Indonesia in the future , requiring the use of expensive drugs for the treatment of typhoid .',
  'Scrub typhus is a serious public health problem in the Asia-Pacific area .',
  'Typhoid fever remains a serious public health problem in developing countries , especially among young children .',
  'Rickettsial diseases ( typhus and spotted fever group rickettsioses , scrub typhus and Q fever ) may pose a serious public health problem , namely when they are non-diagnosed or misdiagnosed .',
  'Pandemic V. parahaemolyticus isolates have become a serious public health concern .',
  'Detection of a significant number of positive Widal tests in conditions where it is expected to be nonreactive appears to be a serious problem in making a correct diagnosis of typhoid fever , thus challenging the diagnostic utility of the Widal test .',
  'Scrub typhus , a serious public health problem in the Asia-Pacific area , is endemic in the " tsutsugamushi triangle " area .',
  'Typhoid fever remains a serious public health problem with a high impact on toddlers and young children .',
  'Moderately and severely immunocompromised travellers are at increased risk of developing a serious health problem during or after a trip in a tropical country .',
  'Typhoid and paratyphoid fevers ( TPF ) , systemic emerging infectious diseases , is a serious health problem for society .',
  'In Poland each year between the first and the second world war typhoid fever was a serious sanitary problem .',
  'Typhoid fever is a global infectious disease which remains a severe health problem in Asia and Africa .',
  'Being a globally emerging mite-borne zoonotic disease , scrub typhus is a serious public health concern in Nepal .',
  'Typhoid fever remains a severe public health problem in developing countries .',
  'Typhoid fever , caused by Salmonella enterica serovar Typhi ( S. Typhi ) , remains a serious global health concern .',
  'Typhoid fever is a serious infection , and special concern arises when S. typhi complicates pregnancy .',
  'Clonal recycling of hybrid El Tor with increasing virulence in a changing climate and in a region with a growing urban population represents a serious public health concern for Bangladesh .',
  'Typhoid fever is a serious public health problem in Egypt .'],
 'typhus': ['Scrub typhus ( ST ) has emerged as a serious public health problem in India .',
  'The results of the current study enhance the belief that murine typhus is a serious public health problem in Cyprus .',
  'Typhoid fever remains a serious problem in developing countries .',
  'Paratyphoid fever caused by Salmonella Paratyphi A is a serious public health problem in many countries .',
  'Typhoid perforation ileitis is a serious complication of typhoid fever , a common and unfortunate health problem in a resource-poor country like Nigeria .',
  'Typhoid fever remains a serious problem in many developing countries .',
  'Typhoid fever remains a serious public health problem .',
  'Typhoid fever , caused by the pathogen Salmonella enterica serovar Typhi ( S. Typhi ) , is a serious global health concern .',
  'In conclusion drug resistant typhoid fever will become a serious problem in Indonesia in the future , requiring the use of expensive drugs for the treatment of typhoid .',
  'Scrub typhus is a serious public health problem in the Asia-Pacific area .',
  'Typhoid fever remains a serious public health problem in developing countries , especially among young children .',
  'Rickettsial diseases ( typhus and spotted fever group rickettsioses , scrub typhus and Q fever ) may pose a serious public health problem , namely when they are non-diagnosed or misdiagnosed .',
  'Pandemic V. parahaemolyticus isolates have become a serious public health concern .',
  'Detection of a significant number of positive Widal tests in conditions where it is expected to be nonreactive appears to be a serious problem in making a correct diagnosis of typhoid fever , thus challenging the diagnostic utility of the Widal test .',
  'Scrub typhus , a serious public health problem in the Asia-Pacific area , is endemic in the " tsutsugamushi triangle " area .',
  'Typhoid fever remains a serious public health problem with a high impact on toddlers and young children .',
  'Moderately and severely immunocompromised travellers are at increased risk of developing a serious health problem during or after a trip in a tropical country .',
  'Typhoid and paratyphoid fevers ( TPF ) , systemic emerging infectious diseases , is a serious health problem for society .',
  'In Poland each year between the first and the second world war typhoid fever was a serious sanitary problem .',
  'Typhoid fever is a global infectious disease which remains a severe health problem in Asia and Africa .',
  'Being a globally emerging mite-borne zoonotic disease , scrub typhus is a serious public health concern in Nepal .',
  'Typhoid fever remains a severe public health problem in developing countries .',
  'Typhoid fever , caused by Salmonella enterica serovar Typhi ( S. Typhi ) , remains a serious global health concern .',
  'Typhoid fever is a serious infection , and special concern arises when S. typhi complicates pregnancy .',
  'Clonal recycling of hybrid El Tor with increasing virulence in a changing climate and in a region with a growing urban population represents a serious public health concern for Bangladesh .',
  'Typhoid fever is a serious public health problem in Egypt .'],
 'fluoride': ['In many parts of the globe , where water contains large amount of fluoride , fluorosis is a serious public health problem .',
  'Fluoride intoxication is a serious public health problem in Senegal .',
  'Fluorosis is a serious public health problem in many parts of the world where drinking water contains more than 1 ppm of fluoride .',
  'Chronic fluoride intoxication through drinking water is a serious health problem .',
  'Endemic fluorosis is a serious problem in public health .',
  'Exposure to fluoride and excessive ethanol consumption has been identified as a serious public health problem in many parts of the world , including India .',
  'Very mild and mild fluorosis is not a serious problem for either the clinician or the patient .',
  'The concentration of fluoride in ground drinking water greater than the world health organization standard value imposes a serious health , social and economic problem in developing countries .',
  'It is well known that excess fluoride intake can result in fluorosis , which is a serious public health problem .',
  'Therefore , reducing the level of FR900525 was a serious problem in the industrial strain A. In this study , we aimed to reduce the FR900525 production .',
  'Fluoride ( F ) contaminated ground water poses a serious public health concern to rural population with unaffordable purification technologies .',
  'It is a serious public health concern as it is a noteworthy medical problem in 24 nations including India yet the threat of fluorosis has not been rooted out .',
  'Our findings suggest that TFA pollution around fluoride production plants is a serious problem and that actions are required to avoid exacerbating the local ecological and environmental risks of TFA .',
  'Apart from the high exposure , fluoride deficiency might be a severe problem in this region due to the very low concentration of fluoride ( < 0.50 \xa0 mg/L ) in drinking water .',
  'Fluorine may result in damage to teeth , bones and other body tissues , and is a serious public health problem .',
  'Fluorosis is a serious public health problem in many parts of the world .',
  'Although early-life fluoride exposure causing fluorosis is well reported in the literature , the dental profession considers it primarily as an esthetic rather than a serious systemic problem .',
  'Fluoride contamination is a severe problem affecting the safety of drinking water around the world .',
  'Endemic fluorosis is a serious problem in public health , affecting thousands of people .',
  'Fluoride contamination of groundwater is a serious problem in several countries of the world because of the intake of excessive fluoride caused by the drinking of the contaminated groundwater .',
  'Fluorosis is still a serious public health problem in China according to our field investigation .',
  'There is a severe fluoride problem in Nawa tehsil of Nagaur district .'],
 'fluorosis': ['In many parts of the globe , where water contains large amount of fluoride , fluorosis is a serious public health problem .',
  'Fluoride intoxication is a serious public health problem in Senegal .',
  'Fluorosis is a serious public health problem in many parts of the world where drinking water contains more than 1 ppm of fluoride .',
  'Chronic fluoride intoxication through drinking water is a serious health problem .',
  'Endemic fluorosis is a serious problem in public health .',
  'Exposure to fluoride and excessive ethanol consumption has been identified as a serious public health problem in many parts of the world , including India .',
  'Very mild and mild fluorosis is not a serious problem for either the clinician or the patient .',
  'The concentration of fluoride in ground drinking water greater than the world health organization standard value imposes a serious health , social and economic problem in developing countries .',
  'It is well known that excess fluoride intake can result in fluorosis , which is a serious public health problem .',
  'Therefore , reducing the level of FR900525 was a serious problem in the industrial strain A. In this study , we aimed to reduce the FR900525 production .',
  'Fluoride ( F ) contaminated ground water poses a serious public health concern to rural population with unaffordable purification technologies .',
  'It is a serious public health concern as it is a noteworthy medical problem in 24 nations including India yet the threat of fluorosis has not been rooted out .',
  'Our findings suggest that TFA pollution around fluoride production plants is a serious problem and that actions are required to avoid exacerbating the local ecological and environmental risks of TFA .',
  'Apart from the high exposure , fluoride deficiency might be a severe problem in this region due to the very low concentration of fluoride ( < 0.50 \xa0 mg/L ) in drinking water .',
  'Fluorine may result in damage to teeth , bones and other body tissues , and is a serious public health problem .',
  'Fluorosis is a serious public health problem in many parts of the world .',
  'Although early-life fluoride exposure causing fluorosis is well reported in the literature , the dental profession considers it primarily as an esthetic rather than a serious systemic problem .',
  'Fluoride contamination is a severe problem affecting the safety of drinking water around the world .',
  'Endemic fluorosis is a serious problem in public health , affecting thousands of people .',
  'Fluoride contamination of groundwater is a serious problem in several countries of the world because of the intake of excessive fluoride caused by the drinking of the contaminated groundwater .',
  'Fluorosis is still a serious public health problem in China according to our field investigation .',
  'There is a severe fluoride problem in Nawa tehsil of Nagaur district .'],
 'ecc': ['In China , HFRS has been recognized as a severe public health problem with 90 % of the total reported cases in the world .',
  'This clearly showed that ECC continues to be a serious public health problem and that there is a great variety of definitions and diagnoses used worldwide , reflected in the prevalence data .',
  'DR has become a serious public health problem in China .',
  'DF is a serious public health problem and an emerging continuous threat in Guangzhou .',
  'These data underscore the fact that LD is a serious national public health problem in China .',
  'Together , these findings suggest that DENV is becoming more widely established on this continent and that DHF will likely become a serious public-health problem in the near future .',
  'CUD is a serious public health problem , affecting',
  'AHC remains a serious public health problem in Southern and Eastern China that mainly affects farmers and children younger than 9 years .',
  'ECC should be regarded as a serious public health problem .',
  'In conclusion , despite the overall steady decline in the number of AHC cases since the peak in 2010 , it still remains a serious public health problem in Southern and Eastern China that targets on the school aged children under 15 years old .',
  'ECC and S-ECC remain a serious problem among preschool children in Xinjiang .',
  'ECC is a serious public health problem in this population and measures to increase awareness should be undertaken .',
  'From the results we came to conclusion that in the territory of Republic of Kosovo , the HFRS is still a serious health , economic and biological problem .',
  'CED in both comparative studies were a serious public health problem .',
  'HCT-N is expected to become a serious and important problem in Japan because of the increasing number of HCTs from unrelated donors .',
  'ECC is a serious public health problem in this population that requires considerable efforts of early detection and treatment along with successful preventive strategies to decrease the same .',
  'EDCs pose a serious health concern since they may cause a wide range of health problems , starting from pre-birth till adult lifelong exposure .',
  'In conclusion , the rate of SI among HCWs is high in China and SI represents a severe but largely neglected problem .',
  'We did find an alarmingly high prevalence of eBP , recognizing that this signals substantial under-treatment in China of a serious condition , and therefore a major public-health concern .',
  'The results of this study indicate that ECC is a serious problem in Manitoba .',
  'HF remains a serious public health problem worldwide , with increasing age-standardized prevalence and YLD rates in countries with relatively low SDI .'],
 'visceral': ['Visceral leishmaniosis ( VL ) remains a serious public health problem in Brazil .',
  'In Brazil , cutaneous leishmaniasis represents a serious public health problem , and chemotherapy is an important element of the clinical management of this disease .',
  'Despite the advances in the diagnosis and treatment of leishmaniasis , it is still considered as a severe public health problem particularly in developing countries and a great economic burden on the health resources .',
  'Epidemics of fatal visceral leishmaniasis caused by the intracellular protozoan Leishmania are a severe public health problem in tropical and subtropical regions of the world .',
  'Visceral leishmaniasis is a disease caused by Leishmania ( Leishmania ) chagasi and represents a serious public health problem .',
  'Leishmaniasis is considered a serious public health problem in several regions in Brazil and worldwide .',
  'VL in Brazil represents a serious public health problem ; therefore , it is important to study new alternatives to treat infected dogs .',
  'In Brazil , visceral leishmaniasis poses a serious endemic and epidemic problem .',
  'Visceral leishmaniasis ( VL ) is an important neglected disease caused by a protozoan parasite , and represents a serious public health problem in many parts of the world .',
  'Visceral leishmaniasis ( VL ) is a deadly parasitic diseases caused by Leishmania donovani ; it is a major health problem in many countries .',
  'Dogs are the main reservoir for visceral leishmaniasis in urban areas , which has become a serious public health concern in Brazil .',
  'American tegumentary leishmaniasis ( ATL ) is a widespread anthropozoonosis caused by protozoa of the genus Leishmania and is considered a serious public health problem .',
  'Phlebotomine sand flies are vectors of Leishmania parasites causing different clinical forms of leishmaniases that represent a serious emerging public health problem worldwide .',
  'Visceral leishmaniasis ( VL ) is a vector-borne disease affecting humans and domestic animals that constitutes a serious public health problem in many countries .',
  'Several animal models have been established to study visceral leishmaniosis ( VL ) , a worldwide vector-borne disease affecting humans and domestic animals that constitutes a serious public health problem .',
  'Visceral leishmaniasis ( VL ) still represents a serious public health problem in Brazil due to the inefficiency of the control measures currently employed , that included early diagnosis and treatment of human cases , vector control , euthanasia of infected dogs and , recently approved in Brazil , treatment with Milteforam drug .',
  'Leishmaniasis , one of the most neglected diseases , is a serious public health problem in many countries , including Brazil .',
  'Visceral leishmaniasis ( VL ) is a deadly neglected tropical disease that poses a serious problem in various countries all over the world .',
  'In Brazil , visceral leishmaniasis ( VL ) is a serious public health problem because of its magnitude , geographical expansion and potential harms caused by illnesses , including death .',
  'Zoonotic visceral leishmaniasis ( ZVL ) is a serious public health problem in several Brazilian cities .',
  'Caused by infection with Leishmania donovani or L. infantum , VL represents a serious public health problem in endemic regions and is rapidly emerging as an opportunistic infection in HIV patients .',
  'Infection with Leishmania infantum causes the disease visceral leishmaniasis ( VL ) , which is a serious clinical and veterinary problem .',
  'Visceral leishmaniasis is a serious public health problem in Brazil , and control of this disease constitutes a major challenge .',
  'Visceral leishmaniasis ( VL ) represents a serious public health problem , as Leishmania infantum is one of main disease causative agents in the Americas .',
  'Visceral Leishmaniasis ( VL ) is an infectious disease which constitutes a serious public health problem , integrating the list of neglected tropical diseases .',
  'Leishmania ( Viannia ) braziliensis is the major causative agent of American tegumentary leishmaniasis , a disease that has a wide geographical distribution and is a severe public health problem .'],
 'leishmania': ['Visceral leishmaniosis ( VL ) remains a serious public health problem in Brazil .',
  'In Brazil , cutaneous leishmaniasis represents a serious public health problem , and chemotherapy is an important element of the clinical management of this disease .',
  'Despite the advances in the diagnosis and treatment of leishmaniasis , it is still considered as a severe public health problem particularly in developing countries and a great economic burden on the health resources .',
  'Epidemics of fatal visceral leishmaniasis caused by the intracellular protozoan Leishmania are a severe public health problem in tropical and subtropical regions of the world .',
  'Visceral leishmaniasis is a disease caused by Leishmania ( Leishmania ) chagasi and represents a serious public health problem .',
  'Leishmaniasis is considered a serious public health problem in several regions in Brazil and worldwide .',
  'VL in Brazil represents a serious public health problem ; therefore , it is important to study new alternatives to treat infected dogs .',
  'In Brazil , visceral leishmaniasis poses a serious endemic and epidemic problem .',
  'Visceral leishmaniasis ( VL ) is an important neglected disease caused by a protozoan parasite , and represents a serious public health problem in many parts of the world .',
  'Visceral leishmaniasis ( VL ) is a deadly parasitic diseases caused by Leishmania donovani ; it is a major health problem in many countries .',
  'Dogs are the main reservoir for visceral leishmaniasis in urban areas , which has become a serious public health concern in Brazil .',
  'American tegumentary leishmaniasis ( ATL ) is a widespread anthropozoonosis caused by protozoa of the genus Leishmania and is considered a serious public health problem .',
  'Phlebotomine sand flies are vectors of Leishmania parasites causing different clinical forms of leishmaniases that represent a serious emerging public health problem worldwide .',
  'Visceral leishmaniasis ( VL ) is a vector-borne disease affecting humans and domestic animals that constitutes a serious public health problem in many countries .',
  'Several animal models have been established to study visceral leishmaniosis ( VL ) , a worldwide vector-borne disease affecting humans and domestic animals that constitutes a serious public health problem .',
  'Visceral leishmaniasis ( VL ) still represents a serious public health problem in Brazil due to the inefficiency of the control measures currently employed , that included early diagnosis and treatment of human cases , vector control , euthanasia of infected dogs and , recently approved in Brazil , treatment with Milteforam drug .',
  'Leishmaniasis , one of the most neglected diseases , is a serious public health problem in many countries , including Brazil .',
  'Visceral leishmaniasis ( VL ) is a deadly neglected tropical disease that poses a serious problem in various countries all over the world .',
  'In Brazil , visceral leishmaniasis ( VL ) is a serious public health problem because of its magnitude , geographical expansion and potential harms caused by illnesses , including death .',
  'Zoonotic visceral leishmaniasis ( ZVL ) is a serious public health problem in several Brazilian cities .',
  'Caused by infection with Leishmania donovani or L. infantum , VL represents a serious public health problem in endemic regions and is rapidly emerging as an opportunistic infection in HIV patients .',
  'Infection with Leishmania infantum causes the disease visceral leishmaniasis ( VL ) , which is a serious clinical and veterinary problem .',
  'Visceral leishmaniasis is a serious public health problem in Brazil , and control of this disease constitutes a major challenge .',
  'Visceral leishmaniasis ( VL ) represents a serious public health problem , as Leishmania infantum is one of main disease causative agents in the Americas .',
  'Visceral Leishmaniasis ( VL ) is an infectious disease which constitutes a serious public health problem , integrating the list of neglected tropical diseases .',
  'Leishmania ( Viannia ) braziliensis is the major causative agent of American tegumentary leishmaniasis , a disease that has a wide geographical distribution and is a severe public health problem .'],
 'brazil': ['Visceral leishmaniosis ( VL ) remains a serious public health problem in Brazil .',
  'In Brazil , cutaneous leishmaniasis represents a serious public health problem , and chemotherapy is an important element of the clinical management of this disease .',
  'Despite the advances in the diagnosis and treatment of leishmaniasis , it is still considered as a severe public health problem particularly in developing countries and a great economic burden on the health resources .',
  'Epidemics of fatal visceral leishmaniasis caused by the intracellular protozoan Leishmania are a severe public health problem in tropical and subtropical regions of the world .',
  'Visceral leishmaniasis is a disease caused by Leishmania ( Leishmania ) chagasi and represents a serious public health problem .',
  'Leishmaniasis is considered a serious public health problem in several regions in Brazil and worldwide .',
  'VL in Brazil represents a serious public health problem ; therefore , it is important to study new alternatives to treat infected dogs .',
  'In Brazil , visceral leishmaniasis poses a serious endemic and epidemic problem .',
  'Visceral leishmaniasis ( VL ) is an important neglected disease caused by a protozoan parasite , and represents a serious public health problem in many parts of the world .',
  'Visceral leishmaniasis ( VL ) is a deadly parasitic diseases caused by Leishmania donovani ; it is a major health problem in many countries .',
  'Dogs are the main reservoir for visceral leishmaniasis in urban areas , which has become a serious public health concern in Brazil .',
  'American tegumentary leishmaniasis ( ATL ) is a widespread anthropozoonosis caused by protozoa of the genus Leishmania and is considered a serious public health problem .',
  'Phlebotomine sand flies are vectors of Leishmania parasites causing different clinical forms of leishmaniases that represent a serious emerging public health problem worldwide .',
  'Visceral leishmaniasis ( VL ) is a vector-borne disease affecting humans and domestic animals that constitutes a serious public health problem in many countries .',
  'Several animal models have been established to study visceral leishmaniosis ( VL ) , a worldwide vector-borne disease affecting humans and domestic animals that constitutes a serious public health problem .',
  'Visceral leishmaniasis ( VL ) still represents a serious public health problem in Brazil due to the inefficiency of the control measures currently employed , that included early diagnosis and treatment of human cases , vector control , euthanasia of infected dogs and , recently approved in Brazil , treatment with Milteforam drug .',
  'Leishmaniasis , one of the most neglected diseases , is a serious public health problem in many countries , including Brazil .',
  'Visceral leishmaniasis ( VL ) is a deadly neglected tropical disease that poses a serious problem in various countries all over the world .',
  'In Brazil , visceral leishmaniasis ( VL ) is a serious public health problem because of its magnitude , geographical expansion and potential harms caused by illnesses , including death .',
  'Zoonotic visceral leishmaniasis ( ZVL ) is a serious public health problem in several Brazilian cities .',
  'Caused by infection with Leishmania donovani or L. infantum , VL represents a serious public health problem in endemic regions and is rapidly emerging as an opportunistic infection in HIV patients .',
  'Infection with Leishmania infantum causes the disease visceral leishmaniasis ( VL ) , which is a serious clinical and veterinary problem .',
  'Visceral leishmaniasis is a serious public health problem in Brazil , and control of this disease constitutes a major challenge .',
  'Visceral leishmaniasis ( VL ) represents a serious public health problem , as Leishmania infantum is one of main disease causative agents in the Americas .',
  'Visceral Leishmaniasis ( VL ) is an infectious disease which constitutes a serious public health problem , integrating the list of neglected tropical diseases .',
  'Leishmania ( Viannia ) braziliensis is the major causative agent of American tegumentary leishmaniasis , a disease that has a wide geographical distribution and is a severe public health problem .'],
 'hfmd': ['Hand , foot , and mouth disease(HFMD)is caused by mainly enterovirus 71(EV-A71)and coxsackievirus A16(CV-A16),and is a serious healthcare problem worldwide .',
  'Coxsackie virus A16 ( CVA16 ) infections have become a serious public health problem in the Asia-Pacific region .',
  'The epidemic of hand , foot , and mouth disease ( HFMD ) has become a severe public health problem in the world and has also brought a high economic and health burden .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem , and coxsackievirus A6 ( CVA6 ) and coxsackievirus A10 ( CVA10 ) are two of the major causative pathogens , in addition to enterovirus 71 ( EV71 ) and coxsackievirus A16 ( CVA16 ) .',
  'Hand , foot , and mouth disease ( HFMD ) is a common viral childhood illness , that has been a severe public health concern worldwide , particularly in the Asia-Pacific region .',
  'Childhood exanthema caused by different serotypes of coxsackievirus ( CV-A ) and enterovirus A71 ( EV-A71 ) has become a serious global health problem ; it is commonly known as hand , foot , and mouth disease ( HFMD ) .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem .',
  'Enterovirus 71 (EV71)-associated hand , foot and mouth disease has emerged as a serious public health problem in South East Asia over the last decade .',
  'The frequent HFMD outbreaks have become a serious public health problem .',
  'Enterovirus 71 ( EV71 ) and Coxsackievirus A16 ( CVA16 ) , as the main agents causing hand , foot and mouth disease ( HFMD ) , have become a serious public health concern in the Asia-Pacific region .',
  'The re-emergence of C4 after causing a severe HFMD outbreak with \u2009 > \u2009 200 deaths in 2011 - 12 among susceptible young children raises concern of another impending severe outbreak .',
  'Emerging epidemics of hand-foot-and-mouth disease ( HFMD ) associated with enterovirus 71 ( EV71 ) has become a serious concern in mainland China .',
  'Epidemics of hand , foot and mouth disease ( HFMD ) among children in East Asia have been a serious annual public health problem .',
  'The prevalence of diseases caused by EV71 infection has become a serious public health problem in the Western Pacific region .',
  'Mainly induced by the Enterovirus 71 and Coxsackievirus A 16 infections , the frequently occurred HFMD outbreaks have become a serious public health problem in Southeast Asia .',
  'The frequent occurrence of HFMD outbreaks has become a serious public health problem in Asia .',
  'Hand , foot and mouth disease ( HFMD ) is a serious infectious disease , which has become a public health problem .',
  'Hand-foot-mouth disease ( HFMD ) is a serious public health problem with increasing cases and substantial financial burden in China , especially in Wuhan city .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem that has emerged over the past several decades .'],
 'mouth': ['Hand , foot , and mouth disease(HFMD)is caused by mainly enterovirus 71(EV-A71)and coxsackievirus A16(CV-A16),and is a serious healthcare problem worldwide .',
  'Coxsackie virus A16 ( CVA16 ) infections have become a serious public health problem in the Asia-Pacific region .',
  'The epidemic of hand , foot , and mouth disease ( HFMD ) has become a severe public health problem in the world and has also brought a high economic and health burden .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem , and coxsackievirus A6 ( CVA6 ) and coxsackievirus A10 ( CVA10 ) are two of the major causative pathogens , in addition to enterovirus 71 ( EV71 ) and coxsackievirus A16 ( CVA16 ) .',
  'Hand , foot , and mouth disease ( HFMD ) is a common viral childhood illness , that has been a severe public health concern worldwide , particularly in the Asia-Pacific region .',
  'Childhood exanthema caused by different serotypes of coxsackievirus ( CV-A ) and enterovirus A71 ( EV-A71 ) has become a serious global health problem ; it is commonly known as hand , foot , and mouth disease ( HFMD ) .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem .',
  'Enterovirus 71 (EV71)-associated hand , foot and mouth disease has emerged as a serious public health problem in South East Asia over the last decade .',
  'The frequent HFMD outbreaks have become a serious public health problem .',
  'Enterovirus 71 ( EV71 ) and Coxsackievirus A16 ( CVA16 ) , as the main agents causing hand , foot and mouth disease ( HFMD ) , have become a serious public health concern in the Asia-Pacific region .',
  'The re-emergence of C4 after causing a severe HFMD outbreak with \u2009 > \u2009 200 deaths in 2011 - 12 among susceptible young children raises concern of another impending severe outbreak .',
  'Emerging epidemics of hand-foot-and-mouth disease ( HFMD ) associated with enterovirus 71 ( EV71 ) has become a serious concern in mainland China .',
  'Epidemics of hand , foot and mouth disease ( HFMD ) among children in East Asia have been a serious annual public health problem .',
  'The prevalence of diseases caused by EV71 infection has become a serious public health problem in the Western Pacific region .',
  'Mainly induced by the Enterovirus 71 and Coxsackievirus A 16 infections , the frequently occurred HFMD outbreaks have become a serious public health problem in Southeast Asia .',
  'The frequent occurrence of HFMD outbreaks has become a serious public health problem in Asia .',
  'Hand , foot and mouth disease ( HFMD ) is a serious infectious disease , which has become a public health problem .',
  'Hand-foot-mouth disease ( HFMD ) is a serious public health problem with increasing cases and substantial financial burden in China , especially in Wuhan city .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem that has emerged over the past several decades .'],
 'coxsackievirus': ['Hand , foot , and mouth disease(HFMD)is caused by mainly enterovirus 71(EV-A71)and coxsackievirus A16(CV-A16),and is a serious healthcare problem worldwide .',
  'Coxsackie virus A16 ( CVA16 ) infections have become a serious public health problem in the Asia-Pacific region .',
  'The epidemic of hand , foot , and mouth disease ( HFMD ) has become a severe public health problem in the world and has also brought a high economic and health burden .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem , and coxsackievirus A6 ( CVA6 ) and coxsackievirus A10 ( CVA10 ) are two of the major causative pathogens , in addition to enterovirus 71 ( EV71 ) and coxsackievirus A16 ( CVA16 ) .',
  'Hand , foot , and mouth disease ( HFMD ) is a common viral childhood illness , that has been a severe public health concern worldwide , particularly in the Asia-Pacific region .',
  'Childhood exanthema caused by different serotypes of coxsackievirus ( CV-A ) and enterovirus A71 ( EV-A71 ) has become a serious global health problem ; it is commonly known as hand , foot , and mouth disease ( HFMD ) .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem .',
  'Enterovirus 71 (EV71)-associated hand , foot and mouth disease has emerged as a serious public health problem in South East Asia over the last decade .',
  'The frequent HFMD outbreaks have become a serious public health problem .',
  'Enterovirus 71 ( EV71 ) and Coxsackievirus A16 ( CVA16 ) , as the main agents causing hand , foot and mouth disease ( HFMD ) , have become a serious public health concern in the Asia-Pacific region .',
  'The re-emergence of C4 after causing a severe HFMD outbreak with \u2009 > \u2009 200 deaths in 2011 - 12 among susceptible young children raises concern of another impending severe outbreak .',
  'Emerging epidemics of hand-foot-and-mouth disease ( HFMD ) associated with enterovirus 71 ( EV71 ) has become a serious concern in mainland China .',
  'Epidemics of hand , foot and mouth disease ( HFMD ) among children in East Asia have been a serious annual public health problem .',
  'The prevalence of diseases caused by EV71 infection has become a serious public health problem in the Western Pacific region .',
  'Mainly induced by the Enterovirus 71 and Coxsackievirus A 16 infections , the frequently occurred HFMD outbreaks have become a serious public health problem in Southeast Asia .',
  'The frequent occurrence of HFMD outbreaks has become a serious public health problem in Asia .',
  'Hand , foot and mouth disease ( HFMD ) is a serious infectious disease , which has become a public health problem .',
  'Hand-foot-mouth disease ( HFMD ) is a serious public health problem with increasing cases and substantial financial burden in China , especially in Wuhan city .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem that has emerged over the past several decades .'],
 'enterovirus': ['Hand , foot , and mouth disease(HFMD)is caused by mainly enterovirus 71(EV-A71)and coxsackievirus A16(CV-A16),and is a serious healthcare problem worldwide .',
  'Coxsackie virus A16 ( CVA16 ) infections have become a serious public health problem in the Asia-Pacific region .',
  'The epidemic of hand , foot , and mouth disease ( HFMD ) has become a severe public health problem in the world and has also brought a high economic and health burden .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem , and coxsackievirus A6 ( CVA6 ) and coxsackievirus A10 ( CVA10 ) are two of the major causative pathogens , in addition to enterovirus 71 ( EV71 ) and coxsackievirus A16 ( CVA16 ) .',
  'Hand , foot , and mouth disease ( HFMD ) is a common viral childhood illness , that has been a severe public health concern worldwide , particularly in the Asia-Pacific region .',
  'Childhood exanthema caused by different serotypes of coxsackievirus ( CV-A ) and enterovirus A71 ( EV-A71 ) has become a serious global health problem ; it is commonly known as hand , foot , and mouth disease ( HFMD ) .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem .',
  'Enterovirus 71 (EV71)-associated hand , foot and mouth disease has emerged as a serious public health problem in South East Asia over the last decade .',
  'The frequent HFMD outbreaks have become a serious public health problem .',
  'Enterovirus 71 ( EV71 ) and Coxsackievirus A16 ( CVA16 ) , as the main agents causing hand , foot and mouth disease ( HFMD ) , have become a serious public health concern in the Asia-Pacific region .',
  'The re-emergence of C4 after causing a severe HFMD outbreak with \u2009 > \u2009 200 deaths in 2011 - 12 among susceptible young children raises concern of another impending severe outbreak .',
  'Emerging epidemics of hand-foot-and-mouth disease ( HFMD ) associated with enterovirus 71 ( EV71 ) has become a serious concern in mainland China .',
  'Epidemics of hand , foot and mouth disease ( HFMD ) among children in East Asia have been a serious annual public health problem .',
  'The prevalence of diseases caused by EV71 infection has become a serious public health problem in the Western Pacific region .',
  'Mainly induced by the Enterovirus 71 and Coxsackievirus A 16 infections , the frequently occurred HFMD outbreaks have become a serious public health problem in Southeast Asia .',
  'The frequent occurrence of HFMD outbreaks has become a serious public health problem in Asia .',
  'Hand , foot and mouth disease ( HFMD ) is a serious infectious disease , which has become a public health problem .',
  'Hand-foot-mouth disease ( HFMD ) is a serious public health problem with increasing cases and substantial financial burden in China , especially in Wuhan city .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem that has emerged over the past several decades .'],
 'cva16': ['Hand , foot , and mouth disease(HFMD)is caused by mainly enterovirus 71(EV-A71)and coxsackievirus A16(CV-A16),and is a serious healthcare problem worldwide .',
  'Coxsackie virus A16 ( CVA16 ) infections have become a serious public health problem in the Asia-Pacific region .',
  'The epidemic of hand , foot , and mouth disease ( HFMD ) has become a severe public health problem in the world and has also brought a high economic and health burden .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem , and coxsackievirus A6 ( CVA6 ) and coxsackievirus A10 ( CVA10 ) are two of the major causative pathogens , in addition to enterovirus 71 ( EV71 ) and coxsackievirus A16 ( CVA16 ) .',
  'Hand , foot , and mouth disease ( HFMD ) is a common viral childhood illness , that has been a severe public health concern worldwide , particularly in the Asia-Pacific region .',
  'Childhood exanthema caused by different serotypes of coxsackievirus ( CV-A ) and enterovirus A71 ( EV-A71 ) has become a serious global health problem ; it is commonly known as hand , foot , and mouth disease ( HFMD ) .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem .',
  'Enterovirus 71 (EV71)-associated hand , foot and mouth disease has emerged as a serious public health problem in South East Asia over the last decade .',
  'The frequent HFMD outbreaks have become a serious public health problem .',
  'Enterovirus 71 ( EV71 ) and Coxsackievirus A16 ( CVA16 ) , as the main agents causing hand , foot and mouth disease ( HFMD ) , have become a serious public health concern in the Asia-Pacific region .',
  'The re-emergence of C4 after causing a severe HFMD outbreak with \u2009 > \u2009 200 deaths in 2011 - 12 among susceptible young children raises concern of another impending severe outbreak .',
  'Emerging epidemics of hand-foot-and-mouth disease ( HFMD ) associated with enterovirus 71 ( EV71 ) has become a serious concern in mainland China .',
  'Epidemics of hand , foot and mouth disease ( HFMD ) among children in East Asia have been a serious annual public health problem .',
  'The prevalence of diseases caused by EV71 infection has become a serious public health problem in the Western Pacific region .',
  'Mainly induced by the Enterovirus 71 and Coxsackievirus A 16 infections , the frequently occurred HFMD outbreaks have become a serious public health problem in Southeast Asia .',
  'The frequent occurrence of HFMD outbreaks has become a serious public health problem in Asia .',
  'Hand , foot and mouth disease ( HFMD ) is a serious infectious disease , which has become a public health problem .',
  'Hand-foot-mouth disease ( HFMD ) is a serious public health problem with increasing cases and substantial financial burden in China , especially in Wuhan city .',
  'Hand , foot and mouth disease ( HFMD ) is a serious public health problem that has emerged over the past several decades .'],
 'measles': ['In 2007 , measles prevailed among the youth and young adult population in Japan , creating in a serious social problem .',
  'Diphtheria is still a preventable public health problem in many developing countries .',
  'Measles is a serious but preventable public health problem ; appropriate strategies must be devised by national and international public health officials to control the disease in developing and developed countries .',
  'Although CNS complications occurring early and late after acute measles are a serious problem and often fatal , the transient immunosuppression lasting for several weeks after the rash is the major cause of measles-related morbidity and mortality worldwide .',
  'Measles remains as a serious problem of infancy and childhood in the developing world , despite the availability of a vaccine .',
  'Measles is still a severe problem in Eastern Turkey .',
  'Measles is still a severe problem in eastern Turkey .',
  'If the good results reported from the USSR can also be obtained with this simple method of vaccination by aerosol , it may be possible to carry out mass vaccinations against measles with thousands of nonprofessional personnel and thereby quickly eliminate measles in countries where it is still a serious public health problem .',
  'Measles is still a serious problem in our country for undernourished infants and our try suggests that cimetidine can be used in this viral disease to shorten the course .',
  'Measles still represents a serious public health problem worldwide .',
  'Our study indicated that the adult measles cases have become a serious problem in Wujin district , which may mainly relate to the increasing size of the floating population with low measles vaccine coverage .',
  'Measles is an infectious disease that represents a serious public health problem worldwide , being associated with increased susceptibility to secondary infections , especially in the respiratory and gastrointestinal tracts .',
  'Despite a broad vaccination campaign , the disease is still a serious problem worldwide .'],
 'tetanus': ['Severe local swelling has been regarded as a serious safety problem for the booster immunisations of diphtheria tetanus acellular pertussis combined ( DTaP ) vaccine and DT combined toxoids ( DT-td ) .',
  'Pertussis remains a serious problem in many countries .',
  'Tetanus remains a serious problem in public health , particularly in developing countries , despite efficient prevention programs .',
  'Although neonatal tetanus in China has been eliminated since 2012 , non-neonatal tetanus remains a serious public health problem .',
  'With pertussis continuing to pose a serious threat to infants , and greatly affecting adolescents and adults , there remains a need to : ( a ) increase the awareness of physicians as to the growing pertussis problem , ( b ) standardize diagnostic techniques , and ( c ) implement various new vaccine strategies to enhance its control .',
  'Bordetella pertussis infection is endemic and continues to be a serious problem among unvaccinated or incompletely vaccinated infants .',
  'Tetanus is an acute specific infection caused by obligate anaerobes , which is still a serious public health problem .',
  'Pertussis ( whooping cough ) remains an epidemic disease responsible for infant and child morbidity and mortality , and is perceived as a serious public health problem .',
  'Tetanus represented a serious health problem in the Czech Republic until 1974 with a substantial number of deaths .',
  'Non-neonatal tetanus remains a serious public health problem , although neonatal tetanus has been eliminated in China since 2012 .',
  'Selective primary health care : strategies for control of disease in the developing world . XXII . Tetanus : a preventable problem .',
  'Notwithstanding its substantial decline over the last two decades , acquired tetanus is still a serious health problem in most developing countries .',
  'In Utah , the lack of pertussis immunization among young children is a serious problem : greater than 30 % of 1-year-old children were not adequately protected .',
  'Worldwide , pertussis remains a serious health concern , especially for infants , who bear the greatest disease burden .'],
 'pertussis': ['Severe local swelling has been regarded as a serious safety problem for the booster immunisations of diphtheria tetanus acellular pertussis combined ( DTaP ) vaccine and DT combined toxoids ( DT-td ) .',
  'Pertussis remains a serious problem in many countries .',
  'Tetanus remains a serious problem in public health , particularly in developing countries , despite efficient prevention programs .',
  'Although neonatal tetanus in China has been eliminated since 2012 , non-neonatal tetanus remains a serious public health problem .',
  'With pertussis continuing to pose a serious threat to infants , and greatly affecting adolescents and adults , there remains a need to : ( a ) increase the awareness of physicians as to the growing pertussis problem , ( b ) standardize diagnostic techniques , and ( c ) implement various new vaccine strategies to enhance its control .',
  'Bordetella pertussis infection is endemic and continues to be a serious problem among unvaccinated or incompletely vaccinated infants .',
  'Tetanus is an acute specific infection caused by obligate anaerobes , which is still a serious public health problem .',
  'Pertussis ( whooping cough ) remains an epidemic disease responsible for infant and child morbidity and mortality , and is perceived as a serious public health problem .',
  'Tetanus represented a serious health problem in the Czech Republic until 1974 with a substantial number of deaths .',
  'Non-neonatal tetanus remains a serious public health problem , although neonatal tetanus has been eliminated in China since 2012 .',
  'Selective primary health care : strategies for control of disease in the developing world . XXII . Tetanus : a preventable problem .',
  'Notwithstanding its substantial decline over the last two decades , acquired tetanus is still a serious health problem in most developing countries .',
  'In Utah , the lack of pertussis immunization among young children is a serious problem : greater than 30 % of 1-year-old children were not adequately protected .',
  'Worldwide , pertussis remains a serious health concern , especially for infants , who bear the greatest disease burden .'],
 'leptospirosis': ['Rural health problems in the Philippines : a symposium , is rural health a serious public health problem in the Philippines ?',
  'Leptospirosis is a worldwide zoonotic disease and a serious , under-reported public health problem , particularly in rural areas of Tanzania .',
  'Considered as a neglected tropical zoonotic disease , leptospirosis is culminating as a serious problem worldwide , seemingly existing as co-infections with various other unrelated diseases , including dengue and malaria .',
  'Leptospirosis is highly endemic in the Philippines and a serious concern to public health .',
  'Leptospirosis is a serious public health concern worldwide .',
  'Persistent High Leptospiral Shedding by Asymptomatic Dogs in Endemic Areas Triggers a Serious Public Health Concern .',
  'Leptospirosis is a serious public health concern in the Philippines , not only because of its increasing incidence rate , but also because of its significant health and economic impacts .',
  'Pathogenic Leptospira is the aetiological agent of leptospirosis , a life-threatening disease of human and veterinary concern .',
  'Leptospirosis probably constitutes a serious veterinary and public health problem in Central America but solid figures are missing .',
  'Leptospirosis , a disease caused by Leptospira species , a spirochaete bacterium that can develop in an appropriate environment and/or grow in human and/or animal hosts , is a serious problem for the Ministry of Public Health , Thailand .',
  'Bovine leptospirosis is a serious economic problem for cattle production , causing abortions , reduced milk yield , mortality in calves and decreased daily weight gain .',
  'Leptospirosis is a serious zoonotic disease that has become an important public health problem .',
  'High number of asymptomatic dogs as leptospiral carriers in an endemic area indicates a serious public health concern .'],
 'philippines': ['Rural health problems in the Philippines : a symposium , is rural health a serious public health problem in the Philippines ?',
  'Leptospirosis is a worldwide zoonotic disease and a serious , under-reported public health problem , particularly in rural areas of Tanzania .',
  'Considered as a neglected tropical zoonotic disease , leptospirosis is culminating as a serious problem worldwide , seemingly existing as co-infections with various other unrelated diseases , including dengue and malaria .',
  'Leptospirosis is highly endemic in the Philippines and a serious concern to public health .',
  'Leptospirosis is a serious public health concern worldwide .',
  'Persistent High Leptospiral Shedding by Asymptomatic Dogs in Endemic Areas Triggers a Serious Public Health Concern .',
  'Leptospirosis is a serious public health concern in the Philippines , not only because of its increasing incidence rate , but also because of its significant health and economic impacts .',
  'Pathogenic Leptospira is the aetiological agent of leptospirosis , a life-threatening disease of human and veterinary concern .',
  'Leptospirosis probably constitutes a serious veterinary and public health problem in Central America but solid figures are missing .',
  'Leptospirosis , a disease caused by Leptospira species , a spirochaete bacterium that can develop in an appropriate environment and/or grow in human and/or animal hosts , is a serious problem for the Ministry of Public Health , Thailand .',
  'Bovine leptospirosis is a serious economic problem for cattle production , causing abortions , reduced milk yield , mortality in calves and decreased daily weight gain .',
  'Leptospirosis is a serious zoonotic disease that has become an important public health problem .',
  'High number of asymptomatic dogs as leptospiral carriers in an endemic area indicates a serious public health concern .'],
 'leptospiral': ['Rural health problems in the Philippines : a symposium , is rural health a serious public health problem in the Philippines ?',
  'Leptospirosis is a worldwide zoonotic disease and a serious , under-reported public health problem , particularly in rural areas of Tanzania .',
  'Considered as a neglected tropical zoonotic disease , leptospirosis is culminating as a serious problem worldwide , seemingly existing as co-infections with various other unrelated diseases , including dengue and malaria .',
  'Leptospirosis is highly endemic in the Philippines and a serious concern to public health .',
  'Leptospirosis is a serious public health concern worldwide .',
  'Persistent High Leptospiral Shedding by Asymptomatic Dogs in Endemic Areas Triggers a Serious Public Health Concern .',
  'Leptospirosis is a serious public health concern in the Philippines , not only because of its increasing incidence rate , but also because of its significant health and economic impacts .',
  'Pathogenic Leptospira is the aetiological agent of leptospirosis , a life-threatening disease of human and veterinary concern .',
  'Leptospirosis probably constitutes a serious veterinary and public health problem in Central America but solid figures are missing .',
  'Leptospirosis , a disease caused by Leptospira species , a spirochaete bacterium that can develop in an appropriate environment and/or grow in human and/or animal hosts , is a serious problem for the Ministry of Public Health , Thailand .',
  'Bovine leptospirosis is a serious economic problem for cattle production , causing abortions , reduced milk yield , mortality in calves and decreased daily weight gain .',
  'Leptospirosis is a serious zoonotic disease that has become an important public health problem .',
  'High number of asymptomatic dogs as leptospiral carriers in an endemic area indicates a serious public health concern .'],
 'leptospira': ['Rural health problems in the Philippines : a symposium , is rural health a serious public health problem in the Philippines ?',
  'Leptospirosis is a worldwide zoonotic disease and a serious , under-reported public health problem , particularly in rural areas of Tanzania .',
  'Considered as a neglected tropical zoonotic disease , leptospirosis is culminating as a serious problem worldwide , seemingly existing as co-infections with various other unrelated diseases , including dengue and malaria .',
  'Leptospirosis is highly endemic in the Philippines and a serious concern to public health .',
  'Leptospirosis is a serious public health concern worldwide .',
  'Persistent High Leptospiral Shedding by Asymptomatic Dogs in Endemic Areas Triggers a Serious Public Health Concern .',
  'Leptospirosis is a serious public health concern in the Philippines , not only because of its increasing incidence rate , but also because of its significant health and economic impacts .',
  'Pathogenic Leptospira is the aetiological agent of leptospirosis , a life-threatening disease of human and veterinary concern .',
  'Leptospirosis probably constitutes a serious veterinary and public health problem in Central America but solid figures are missing .',
  'Leptospirosis , a disease caused by Leptospira species , a spirochaete bacterium that can develop in an appropriate environment and/or grow in human and/or animal hosts , is a serious problem for the Ministry of Public Health , Thailand .',
  'Bovine leptospirosis is a serious economic problem for cattle production , causing abortions , reduced milk yield , mortality in calves and decreased daily weight gain .',
  'Leptospirosis is a serious zoonotic disease that has become an important public health problem .',
  'High number of asymptomatic dogs as leptospiral carriers in an endemic area indicates a serious public health concern .'],
 'zoonotic': ['Rural health problems in the Philippines : a symposium , is rural health a serious public health problem in the Philippines ?',
  'Leptospirosis is a worldwide zoonotic disease and a serious , under-reported public health problem , particularly in rural areas of Tanzania .',
  'Considered as a neglected tropical zoonotic disease , leptospirosis is culminating as a serious problem worldwide , seemingly existing as co-infections with various other unrelated diseases , including dengue and malaria .',
  'Leptospirosis is highly endemic in the Philippines and a serious concern to public health .',
  'Leptospirosis is a serious public health concern worldwide .',
  'Persistent High Leptospiral Shedding by Asymptomatic Dogs in Endemic Areas Triggers a Serious Public Health Concern .',
  'Leptospirosis is a serious public health concern in the Philippines , not only because of its increasing incidence rate , but also because of its significant health and economic impacts .',
  'Pathogenic Leptospira is the aetiological agent of leptospirosis , a life-threatening disease of human and veterinary concern .',
  'Leptospirosis probably constitutes a serious veterinary and public health problem in Central America but solid figures are missing .',
  'Leptospirosis , a disease caused by Leptospira species , a spirochaete bacterium that can develop in an appropriate environment and/or grow in human and/or animal hosts , is a serious problem for the Ministry of Public Health , Thailand .',
  'Bovine leptospirosis is a serious economic problem for cattle production , causing abortions , reduced milk yield , mortality in calves and decreased daily weight gain .',
  'Leptospirosis is a serious zoonotic disease that has become an important public health problem .',
  'High number of asymptomatic dogs as leptospiral carriers in an endemic area indicates a serious public health concern .'],
 'delphinium': ['Consumption of ponderosa pine needles causes late-term abortions in cattle and is a serious poisonous plant problem in foothill and mountain rangelands .',
  'Poisonous plants are a serious problem for cattle breeding in Latin America .',
  'Pine needle-induced abortion in cattle is a serious problem in many areas of western United States and Canada .',
  'Frequently the initial and only indication that a severe problem exists with peracute poisoning in a cattle herd is dead animals .',
  'Tall larkspur ( Delphinium spp . ) is a serious toxic plant problem on western U.S. ranges .',
  'As a devastating holoparasitic weed , Orobanche aegyptiaca Persoon . ( Egyptian broomrape ) causes serious damage to agricultural production and threatens economic development , which has raised widespread concern .',
  'The contamination of green fodder with houndstongue can be a serious problem for the feeding practice in certain regions ( dry grassland , loess or shell lime soil , extensive management ) .',
  'Larkspurs ( Delphinium spp . ) are a serious toxic plant problem for cattle in western North America .',
  'Tall larkspur poisoning of cattle is a serious problem on western US rangelands .',
  'Larkspur ( Delphinium sp ) poisoning of range cattle is a serious , recurring problem in the western United States .',
  'Locoweed species ( Astragalus and Oxytropis spp . ) are a serious toxic plant problem for grazing livestock .',
  'Locoweed ( Oxytropis sericea ) is a serious poisoning problem for horses grazing on infested rangelands in the western United States .'],
 'larkspur': ['Consumption of ponderosa pine needles causes late-term abortions in cattle and is a serious poisonous plant problem in foothill and mountain rangelands .',
  'Poisonous plants are a serious problem for cattle breeding in Latin America .',
  'Pine needle-induced abortion in cattle is a serious problem in many areas of western United States and Canada .',
  'Frequently the initial and only indication that a severe problem exists with peracute poisoning in a cattle herd is dead animals .',
  'Tall larkspur ( Delphinium spp . ) is a serious toxic plant problem on western U.S. ranges .',
  'As a devastating holoparasitic weed , Orobanche aegyptiaca Persoon . ( Egyptian broomrape ) causes serious damage to agricultural production and threatens economic development , which has raised widespread concern .',
  'The contamination of green fodder with houndstongue can be a serious problem for the feeding practice in certain regions ( dry grassland , loess or shell lime soil , extensive management ) .',
  'Larkspurs ( Delphinium spp . ) are a serious toxic plant problem for cattle in western North America .',
  'Tall larkspur poisoning of cattle is a serious problem on western US rangelands .',
  'Larkspur ( Delphinium sp ) poisoning of range cattle is a serious , recurring problem in the western United States .',
  'Locoweed species ( Astragalus and Oxytropis spp . ) are a serious toxic plant problem for grazing livestock .',
  'Locoweed ( Oxytropis sericea ) is a serious poisoning problem for horses grazing on infested rangelands in the western United States .'],
 'rangelands': ['Consumption of ponderosa pine needles causes late-term abortions in cattle and is a serious poisonous plant problem in foothill and mountain rangelands .',
  'Poisonous plants are a serious problem for cattle breeding in Latin America .',
  'Pine needle-induced abortion in cattle is a serious problem in many areas of western United States and Canada .',
  'Frequently the initial and only indication that a severe problem exists with peracute poisoning in a cattle herd is dead animals .',
  'Tall larkspur ( Delphinium spp . ) is a serious toxic plant problem on western U.S. ranges .',
  'As a devastating holoparasitic weed , Orobanche aegyptiaca Persoon . ( Egyptian broomrape ) causes serious damage to agricultural production and threatens economic development , which has raised widespread concern .',
  'The contamination of green fodder with houndstongue can be a serious problem for the feeding practice in certain regions ( dry grassland , loess or shell lime soil , extensive management ) .',
  'Larkspurs ( Delphinium spp . ) are a serious toxic plant problem for cattle in western North America .',
  'Tall larkspur poisoning of cattle is a serious problem on western US rangelands .',
  'Larkspur ( Delphinium sp ) poisoning of range cattle is a serious , recurring problem in the western United States .',
  'Locoweed species ( Astragalus and Oxytropis spp . ) are a serious toxic plant problem for grazing livestock .',
  'Locoweed ( Oxytropis sericea ) is a serious poisoning problem for horses grazing on infested rangelands in the western United States .'],
 'locoweed': ['Consumption of ponderosa pine needles causes late-term abortions in cattle and is a serious poisonous plant problem in foothill and mountain rangelands .',
  'Poisonous plants are a serious problem for cattle breeding in Latin America .',
  'Pine needle-induced abortion in cattle is a serious problem in many areas of western United States and Canada .',
  'Frequently the initial and only indication that a severe problem exists with peracute poisoning in a cattle herd is dead animals .',
  'Tall larkspur ( Delphinium spp . ) is a serious toxic plant problem on western U.S. ranges .',
  'As a devastating holoparasitic weed , Orobanche aegyptiaca Persoon . ( Egyptian broomrape ) causes serious damage to agricultural production and threatens economic development , which has raised widespread concern .',
  'The contamination of green fodder with houndstongue can be a serious problem for the feeding practice in certain regions ( dry grassland , loess or shell lime soil , extensive management ) .',
  'Larkspurs ( Delphinium spp . ) are a serious toxic plant problem for cattle in western North America .',
  'Tall larkspur poisoning of cattle is a serious problem on western US rangelands .',
  'Larkspur ( Delphinium sp ) poisoning of range cattle is a serious , recurring problem in the western United States .',
  'Locoweed species ( Astragalus and Oxytropis spp . ) are a serious toxic plant problem for grazing livestock .',
  'Locoweed ( Oxytropis sericea ) is a serious poisoning problem for horses grazing on infested rangelands in the western United States .'],
 'poisonous': ['Consumption of ponderosa pine needles causes late-term abortions in cattle and is a serious poisonous plant problem in foothill and mountain rangelands .',
  'Poisonous plants are a serious problem for cattle breeding in Latin America .',
  'Pine needle-induced abortion in cattle is a serious problem in many areas of western United States and Canada .',
  'Frequently the initial and only indication that a severe problem exists with peracute poisoning in a cattle herd is dead animals .',
  'Tall larkspur ( Delphinium spp . ) is a serious toxic plant problem on western U.S. ranges .',
  'As a devastating holoparasitic weed , Orobanche aegyptiaca Persoon . ( Egyptian broomrape ) causes serious damage to agricultural production and threatens economic development , which has raised widespread concern .',
  'The contamination of green fodder with houndstongue can be a serious problem for the feeding practice in certain regions ( dry grassland , loess or shell lime soil , extensive management ) .',
  'Larkspurs ( Delphinium spp . ) are a serious toxic plant problem for cattle in western North America .',
  'Tall larkspur poisoning of cattle is a serious problem on western US rangelands .',
  'Larkspur ( Delphinium sp ) poisoning of range cattle is a serious , recurring problem in the western United States .',
  'Locoweed species ( Astragalus and Oxytropis spp . ) are a serious toxic plant problem for grazing livestock .',
  'Locoweed ( Oxytropis sericea ) is a serious poisoning problem for horses grazing on infested rangelands in the western United States .'],
 'subarachnoid': ['Subarachnoid hemorrhage ( SAH ) is a devastating form of stroke , which poses a series of intractable challenges to clinical practice .',
  'Aneurysmal subarachnoid hemorrhage ( aSAH ) is a devastating problem .',
  'Cerebral aneurysm re-rupture following subarachnoid hemorrhage(SAH)is a serious problem that is related with poor outcome .',
  'Aneurysmal subarachnoid hemorrhage is a serious medical and social problem .',
  'Subarachnoid hemorrhage ( SAH ) is a serious medical problem with few effective pharmacotherapies available , and neuroinflammation has been identified as an important pathological process in early brain injury ( EBI ) after SAH .',
  'Cerebral vasospasm secondary to subarachnoid hemorrhage ( SAH ) has been a serious clinical problem .',
  'The development of delayed cerebral ischaemia and hence neurological deficit remains a serious problem following subarachnoid haemorrhage .',
  'While the risk of aneurysmal rebleeding induced by catheter cerebral angiography is a serious concern and can delay angiography for a few hours after a subarachnoid hemorrhage ( SAH ) , current angiographic technology and techniques have been much improved .',
  'Delayed neurologic deficits secondary to vasospasm remain a vexing problem .',
  'Cerebral vasospasm remains a serious problem affecting morbidity and mortality in patients with subarachnoid hemorrhage ( SAH ) during neurosurgery .',
  'Despite decades of study , subarachnoid hemorrhage ( SAH ) continues to be a serious and significant health problem in the United States and worldwide .',
  'Poor outcome in patients with cerebral vasospasm following subarachnoid hemorrhage remains a serious clinical problem .'],
 'aneurysmal': ['Subarachnoid hemorrhage ( SAH ) is a devastating form of stroke , which poses a series of intractable challenges to clinical practice .',
  'Aneurysmal subarachnoid hemorrhage ( aSAH ) is a devastating problem .',
  'Cerebral aneurysm re-rupture following subarachnoid hemorrhage(SAH)is a serious problem that is related with poor outcome .',
  'Aneurysmal subarachnoid hemorrhage is a serious medical and social problem .',
  'Subarachnoid hemorrhage ( SAH ) is a serious medical problem with few effective pharmacotherapies available , and neuroinflammation has been identified as an important pathological process in early brain injury ( EBI ) after SAH .',
  'Cerebral vasospasm secondary to subarachnoid hemorrhage ( SAH ) has been a serious clinical problem .',
  'The development of delayed cerebral ischaemia and hence neurological deficit remains a serious problem following subarachnoid haemorrhage .',
  'While the risk of aneurysmal rebleeding induced by catheter cerebral angiography is a serious concern and can delay angiography for a few hours after a subarachnoid hemorrhage ( SAH ) , current angiographic technology and techniques have been much improved .',
  'Delayed neurologic deficits secondary to vasospasm remain a vexing problem .',
  'Cerebral vasospasm remains a serious problem affecting morbidity and mortality in patients with subarachnoid hemorrhage ( SAH ) during neurosurgery .',
  'Despite decades of study , subarachnoid hemorrhage ( SAH ) continues to be a serious and significant health problem in the United States and worldwide .',
  'Poor outcome in patients with cerebral vasospasm following subarachnoid hemorrhage remains a serious clinical problem .'],
 'catheter': ['It is our experience that the use of catehters in patients requiring short/medium- term PN is a safe procedure with few complications ; patients on home long-term PN present an increasing number of complications , and the vascular access could become a serious problem as the number of PN-dependent increases .',
  'Bacteremia is often a serious and recurring problem in children with hemodialysis catheters .',
  'Catheter-related bloodstream infections are a serious problem .',
  'Catheter-related bacteriuria is a serious problem of elderly patients residing in nursing homes and extended care facilities .',
  'Although rare , epidural catheter-associated infections remain a serious concern in high-risk children who may benefit the most from epidural analgesia .',
  'The adhesion of microbes to catheter surfaces is a serious problem and the resulting infections frequently lead to longer hospitalisation and higher risk for the patient .',
  'Intravascular catheter-related infection and associated bacteraemia constitute a serious and increasing problem among nosocomial infections .',
  'Vascular infections are a serious problem , often associated with high morbidity and mortality .',
  'Totally implantable venous access port (TIVAP)-related infections ( RIs ) remain a serious health problem in cancer patients receiving an intravenous ( i.v . ) therapy .',
  'Microbial colonization of urinary catheters remains a serious problem for medicine as it often leads to biofilm formation and infection .',
  'Minor complications encountered upon using the catheter were solved by our method , however , infection represents a serious problem .',
  'Catheter-related bloodstream infections ( BSIs ) are a serious problem leading to increased morbidity , longer hospital stay , and hence , additional costs .',
  'We conclude that the Y-set system is associated with reduced numbers of catheter infections , but that catheter loss from catheter infections remains a serious problem .',
  'Catheter infection continues to be a serious problem in critically ill patients .',
  'The knotted Swan-Ganz catheter : new solution to a vexing problem .',
  'Physicians who treat neonates who become bacteremic while dependent on central venous catheters face a serious and common dilemma .',
  'Sepsis from central triple-lumen catheters remains a serious and life-threatening problem .',
  'For many patients with a long-term indwelling catheter , encrustations can be a severe problem .',
  'Bacteriuria -- asymptomatic and symptomatic -- always has the potential to develop into a serious problem when intermittent catheterization is being used .'],
 'catheters': ['It is our experience that the use of catehters in patients requiring short/medium- term PN is a safe procedure with few complications ; patients on home long-term PN present an increasing number of complications , and the vascular access could become a serious problem as the number of PN-dependent increases .',
  'Bacteremia is often a serious and recurring problem in children with hemodialysis catheters .',
  'Catheter-related bloodstream infections are a serious problem .',
  'Catheter-related bacteriuria is a serious problem of elderly patients residing in nursing homes and extended care facilities .',
  'Although rare , epidural catheter-associated infections remain a serious concern in high-risk children who may benefit the most from epidural analgesia .',
  'The adhesion of microbes to catheter surfaces is a serious problem and the resulting infections frequently lead to longer hospitalisation and higher risk for the patient .',
  'Intravascular catheter-related infection and associated bacteraemia constitute a serious and increasing problem among nosocomial infections .',
  'Vascular infections are a serious problem , often associated with high morbidity and mortality .',
  'Totally implantable venous access port (TIVAP)-related infections ( RIs ) remain a serious health problem in cancer patients receiving an intravenous ( i.v . ) therapy .',
  'Microbial colonization of urinary catheters remains a serious problem for medicine as it often leads to biofilm formation and infection .',
  'Minor complications encountered upon using the catheter were solved by our method , however , infection represents a serious problem .',
  'Catheter-related bloodstream infections ( BSIs ) are a serious problem leading to increased morbidity , longer hospital stay , and hence , additional costs .',
  'We conclude that the Y-set system is associated with reduced numbers of catheter infections , but that catheter loss from catheter infections remains a serious problem .',
  'Catheter infection continues to be a serious problem in critically ill patients .',
  'The knotted Swan-Ganz catheter : new solution to a vexing problem .',
  'Physicians who treat neonates who become bacteremic while dependent on central venous catheters face a serious and common dilemma .',
  'Sepsis from central triple-lumen catheters remains a serious and life-threatening problem .',
  'For many patients with a long-term indwelling catheter , encrustations can be a severe problem .',
  'Bacteriuria -- asymptomatic and symptomatic -- always has the potential to develop into a serious problem when intermittent catheterization is being used .'],
 'difficile': ['A serious epidemiological problem is the high incidence of infection caused by Clostridium difficile .',
  '[ Colitis precipitated by Clostridium difficile - \u200a  a serious current problem ] .',
  'Accelerating rates of health care-associated infections caused by Clostridium difficile , with increasing recurrence and rising antibiotic resistance rates , have become a serious problem in recent years .',
  'A serious epidemiological problem is a strong upward trend in nosocomial infections including infections caused \n by Clostridium difficile .',
  'The disease caused by the bacterium Clostridium difficile/Clostridium difficile associated disease/diarrhoea ( CDAD ) is becoming a serious problem especially in geriatric patients , who are now relatively often treated by broad-spectrum antibiotics .',
  'Over recent years C. difficile diarrhea has become a serious problem in geriatric units .',
  'C. difficile infection is low in Greek intensive care units , but remains a serious problem among the critically-ill .',
  'Intestinal infections caused by the Clostridium difficile ( CDI ) bacterium currently represent a serious medical problem .',
  'Clostridium difficile is a serious epidemiological problem and particularly dangerous microorganism causing hospital infections .',
  '[i]Clostridium difficile[/i ] infections become a serious problem in terms of nosocomial infections , as well as a consequence of common use of antibiotics .',
  'Recurrence of Clostridium difficile-associated diarrhea ( CDAD ) is a serious and still unsolved problem .',
  "Clostridium difficile ( C. difficile ) infection ( CDI ) is a serious problem mostly studied during patients ' index infections .",
  'Among the various infectious diseases , Clostridium difficile infection is associated with a high rate of mortality in elderly individuals and is a serious health problem worldwide , owing to the increasing infection rates .',
  'As the major cause of antibiotic-associated diarrhea , Clostridium difficile is a serious problem in health care facilities worldwide .',
  'Clostridium difficile infection ( CDI ) is a serious problem in hospitalized patients .',
  'Clostridium difficile infection ( CDI ) is a serious problem within the healthcare environment where the bacterium causes symptoms ranging from mild diarrhoea to life-threatening colitis .',
  'Clostridium difficile-associated diarrhoea ( CDAD ) is caused by C. difficile toxins A and B and represents a serious emerging health problem .'],
 'clostridium': ['A serious epidemiological problem is the high incidence of infection caused by Clostridium difficile .',
  '[ Colitis precipitated by Clostridium difficile - \u200a  a serious current problem ] .',
  'Accelerating rates of health care-associated infections caused by Clostridium difficile , with increasing recurrence and rising antibiotic resistance rates , have become a serious problem in recent years .',
  'A serious epidemiological problem is a strong upward trend in nosocomial infections including infections caused \n by Clostridium difficile .',
  'The disease caused by the bacterium Clostridium difficile/Clostridium difficile associated disease/diarrhoea ( CDAD ) is becoming a serious problem especially in geriatric patients , who are now relatively often treated by broad-spectrum antibiotics .',
  'Over recent years C. difficile diarrhea has become a serious problem in geriatric units .',
  'C. difficile infection is low in Greek intensive care units , but remains a serious problem among the critically-ill .',
  'Intestinal infections caused by the Clostridium difficile ( CDI ) bacterium currently represent a serious medical problem .',
  'Clostridium difficile is a serious epidemiological problem and particularly dangerous microorganism causing hospital infections .',
  '[i]Clostridium difficile[/i ] infections become a serious problem in terms of nosocomial infections , as well as a consequence of common use of antibiotics .',
  'Recurrence of Clostridium difficile-associated diarrhea ( CDAD ) is a serious and still unsolved problem .',
  "Clostridium difficile ( C. difficile ) infection ( CDI ) is a serious problem mostly studied during patients ' index infections .",
  'Among the various infectious diseases , Clostridium difficile infection is associated with a high rate of mortality in elderly individuals and is a serious health problem worldwide , owing to the increasing infection rates .',
  'As the major cause of antibiotic-associated diarrhea , Clostridium difficile is a serious problem in health care facilities worldwide .',
  'Clostridium difficile infection ( CDI ) is a serious problem in hospitalized patients .',
  'Clostridium difficile infection ( CDI ) is a serious problem within the healthcare environment where the bacterium causes symptoms ranging from mild diarrhoea to life-threatening colitis .',
  'Clostridium difficile-associated diarrhoea ( CDAD ) is caused by C. difficile toxins A and B and represents a serious emerging health problem .'],
 'bacterium': ['A serious epidemiological problem is the high incidence of infection caused by Clostridium difficile .',
  '[ Colitis precipitated by Clostridium difficile - \u200a  a serious current problem ] .',
  'Accelerating rates of health care-associated infections caused by Clostridium difficile , with increasing recurrence and rising antibiotic resistance rates , have become a serious problem in recent years .',
  'A serious epidemiological problem is a strong upward trend in nosocomial infections including infections caused \n by Clostridium difficile .',
  'The disease caused by the bacterium Clostridium difficile/Clostridium difficile associated disease/diarrhoea ( CDAD ) is becoming a serious problem especially in geriatric patients , who are now relatively often treated by broad-spectrum antibiotics .',
  'Over recent years C. difficile diarrhea has become a serious problem in geriatric units .',
  'C. difficile infection is low in Greek intensive care units , but remains a serious problem among the critically-ill .',
  'Intestinal infections caused by the Clostridium difficile ( CDI ) bacterium currently represent a serious medical problem .',
  'Clostridium difficile is a serious epidemiological problem and particularly dangerous microorganism causing hospital infections .',
  '[i]Clostridium difficile[/i ] infections become a serious problem in terms of nosocomial infections , as well as a consequence of common use of antibiotics .',
  'Recurrence of Clostridium difficile-associated diarrhea ( CDAD ) is a serious and still unsolved problem .',
  "Clostridium difficile ( C. difficile ) infection ( CDI ) is a serious problem mostly studied during patients ' index infections .",
  'Among the various infectious diseases , Clostridium difficile infection is associated with a high rate of mortality in elderly individuals and is a serious health problem worldwide , owing to the increasing infection rates .',
  'As the major cause of antibiotic-associated diarrhea , Clostridium difficile is a serious problem in health care facilities worldwide .',
  'Clostridium difficile infection ( CDI ) is a serious problem in hospitalized patients .',
  'Clostridium difficile infection ( CDI ) is a serious problem within the healthcare environment where the bacterium causes symptoms ranging from mild diarrhoea to life-threatening colitis .',
  'Clostridium difficile-associated diarrhoea ( CDAD ) is caused by C. difficile toxins A and B and represents a serious emerging health problem .'],
 'domestic': ['Although domestic violence ( DV ) is recognized as a serious crime , only recently has it been acknowledged as a critical public health problem .',
  'Domestic violence is a serious problem affecting the health and wellbeing of women globally .',
  'Domestic abuse represents a serious public health and human rights concern .',
  'Domestic abuse is a serious problem that may present directly or indirectly in the clinical setting .',
  'Domestic violence ( DV ) is a serious public health problem in the world .',
  'Gender-based violence against women migrant domestic workers ( WMDW ) is a serious public health concern in the Middle East region .',
  'The study concludes that wife beating is a serious health and social problem for the women population of Kantale .',
  'Domestic violence is a serious public health problem .',
  'Domestic violence is a serious problem with far-reaching consequences .',
  'Domestic family violence ( FV ) is a serious problem with serious impacts on mental health of victims .',
  'Spousal violence against women is a serious public health problem that is prevalent in all societies , with one in three women around the world experiencing violence in their lifetime .',
  'The Canadian government has introduced numerous policies , guidelines , and mandates at the federal and provincial levels that recognize woman abuse as a serious social problem and violation of the law .',
  'Domestic violence ( DV ) against women is a serious problem with its negative effects on all family members and the society .',
  'Domestic abuse is increasingly recognised as a serious , worldwide public health concern .',
  'Domestic abuse of women is a serious problem worldwide that has economic , physical , and psychological consequences , yet in many countries and cultures , victims often have little access to psychological support .',
  'Intimate partner physical violence was found to be high and a serious problem among women in Shimelba refugee camp .',
  'Domestic violence ( DV ) is not only a devastating societal problem , but also a severe medical and mental health problem worldwide .',
  'Given domestic violence continues to be a serious social problem , recently acknowledged as a national public health epidemic as well , the need to examine existing formal helping services and address the barriers to service utilization among battered women is warranted .',
  'The data about domestic violence against women point out a serious problem all around the world along with including cultural differences .',
  'These results underscore that domestic violence is a serious problem that must be addressed in Thai society .',
  'Interpersonal violence is a serious public health problem in the United States .',
  'Violence against women , especially by intimate partners , is a serious public health problem that is associated with physical , reproductive , and mental health consequences .',
  'Family violence is a serious concern in the era of deinstitutionalization in Japan .',
  'Although domestic violence is seen as a serious public health issue for women worldwide , international evidence suggests that women aged over 50 who are victims are suffering in silence because the problem is often ignored by health professionals .',
  'Domestic violence is a serious public health concern in the United States .',
  'Domestic abuse is a serious problem across the world and it is considered a public health issue .',
  'Domestic abuse is a serious global problem and has greater , negative effects on long-term health than more obvious diseases , such as diabetes .',
  'The magnitude , physical and mental health consequences of domestic violence represents a serious reproductive health concern for Pakistan .',
  'Domestic violence , especially violence against women , is a serious health problem in the United States and in many countries of the world .',
  'Domestic violence , a serious health problem , affects millions of people every year .',
  'Domestic violence against women is regarded as an important health problem among women and a serious concern in issues related to human rights .',
  'Domestic violence and partner violence against women is a serious problem in many countries , including Germany .',
  'Given the small number of adult women in Yap , these findings suggest that domestic violence is a serious , pervasive problem that Yap needs urgently to address .',
  'Domestic violence is a serious , complex , public health problem , which is more common than many physicians realize .',
  'Domestic abuse is increasingly recognised as a serious public health concern worldwide .',
  'Domestic violence is a serious problem in the United States , with almost two million incidents occurring every year .',
  'Domestic violence is a serious , preventable health problem affecting more than thirty million Americans annually , yet little is known about federally funded service provision .',
  'Only recently has Japanese society come to realize the magnitude of domestic violence as a serious social problem .',
  'Domestic violence is a serious and often underreported problem .',
  'Domestic violence is a serious and highly prevalent concern among this group of South Asian women .',
  "Domestic violence is a serious public health concern often ' hidden ' by the lack of appropriate data .",
  'Domestic violence is a dangerous and prevalent social problem affecting up to 4 million women and countless children annually .',
  'Domestic violence ( DV ) against women is a serious human rights abuse and well recognised global public health concern .',
  'Violence against women by their male partners is a serious public health problem that has not been adequately addressed by the medical and psychiatric professions .',
  'One-in-three women has experienced domestic violence , which is a serious public health problem and a human right violation .',
  'Domestic violence ( DV ) is a serious problem all over the world which had been extended to boundaries of countries , economical , cultural and racial classes .',
  'Domestic violence is a serious public health and human rights concern and an on-going challenge for nursing .',
  "Domestic violence is a serious women 's health and societal problem .",
  'Multiple regression analysis identified the following statistically significant confounders : victimization , the presence of a person with a severe health problem at home , female sex , engaging in limited physical exercise , and living in a single adult family .'],
 'gonorrhoeae': ['The occurrence of antibiotic resistant Neisseria gonorrhoeae isolates is a serious public health problem in different corners of the globe .',
  'The widespread antimicrobial resistance of Neisseria gonorrhoeae is a serious problem for the treatment and control of gonorrhoea .',
  'Antimicrobial resistance of Neisseria gonorrhoeae is a serious health problem in China .',
  'Gonorrhea in women : a serious health problem .',
  'Gonorrhoea is one of the most common sexually transmitted infections ( STIs ) in the world , and is a serious public health problem because of its associated morbidity and complications .',
  'Multidrug resistance is a serious problem that threatens the effective treatment of the widespread sexually transmitted disease gonorrhea , caused by the Gram-negative bacterium',
  'Antimicrobial resistance ( AMR ) in Neisseria gonorrhoeae is a serious public health problem , compromising the management and control of gonorrhoea globally .',
  'The antimicrobial resistance of Neisseria gonorrhoeae is a serious problem worldwide .',
  'Emergence of multidrug-resistant ( MDR ) and extensively drug-resistant ( XDR ) Neisseria gonorrhoeae is a serious concern and combination therapy has been recommended to delay the onset of treatment failures .',
  'Neisseria gonorrhoeae ( NG ) infection is a serious public health problem .',
  'Increasing rates of gonococcal ( GC ) infection and antimicrobial resistant ( AMR ) GC , are a serious public health concern for Canada and around the world .',
  'Gonococcal infections are now an uncommon problem in newborns in industrialized countries but remain a serious problem in developing countries due to ongoing high infection rates in pregnant women .',
  'The sexually transmitted disease , gonorrhea , is a serious health problem in developed as well as in developing countries , for which treatment continues to be a challenge .',
  'However , this has not become a serious problem to date , as large scale evaluation has shown that the quinolones remain highly efficacious for the treatment of gonorrhoea .'],
 'gonorrhoea': ['The occurrence of antibiotic resistant Neisseria gonorrhoeae isolates is a serious public health problem in different corners of the globe .',
  'The widespread antimicrobial resistance of Neisseria gonorrhoeae is a serious problem for the treatment and control of gonorrhoea .',
  'Antimicrobial resistance of Neisseria gonorrhoeae is a serious health problem in China .',
  'Gonorrhea in women : a serious health problem .',
  'Gonorrhoea is one of the most common sexually transmitted infections ( STIs ) in the world , and is a serious public health problem because of its associated morbidity and complications .',
  'Multidrug resistance is a serious problem that threatens the effective treatment of the widespread sexually transmitted disease gonorrhea , caused by the Gram-negative bacterium',
  'Antimicrobial resistance ( AMR ) in Neisseria gonorrhoeae is a serious public health problem , compromising the management and control of gonorrhoea globally .',
  'The antimicrobial resistance of Neisseria gonorrhoeae is a serious problem worldwide .',
  'Emergence of multidrug-resistant ( MDR ) and extensively drug-resistant ( XDR ) Neisseria gonorrhoeae is a serious concern and combination therapy has been recommended to delay the onset of treatment failures .',
  'Neisseria gonorrhoeae ( NG ) infection is a serious public health problem .',
  'Increasing rates of gonococcal ( GC ) infection and antimicrobial resistant ( AMR ) GC , are a serious public health concern for Canada and around the world .',
  'Gonococcal infections are now an uncommon problem in newborns in industrialized countries but remain a serious problem in developing countries due to ongoing high infection rates in pregnant women .',
  'The sexually transmitted disease , gonorrhea , is a serious health problem in developed as well as in developing countries , for which treatment continues to be a challenge .',
  'However , this has not become a serious problem to date , as large scale evaluation has shown that the quinolones remain highly efficacious for the treatment of gonorrhoea .'],
 'gonorrhea': ['The occurrence of antibiotic resistant Neisseria gonorrhoeae isolates is a serious public health problem in different corners of the globe .',
  'The widespread antimicrobial resistance of Neisseria gonorrhoeae is a serious problem for the treatment and control of gonorrhoea .',
  'Antimicrobial resistance of Neisseria gonorrhoeae is a serious health problem in China .',
  'Gonorrhea in women : a serious health problem .',
  'Gonorrhoea is one of the most common sexually transmitted infections ( STIs ) in the world , and is a serious public health problem because of its associated morbidity and complications .',
  'Multidrug resistance is a serious problem that threatens the effective treatment of the widespread sexually transmitted disease gonorrhea , caused by the Gram-negative bacterium',
  'Antimicrobial resistance ( AMR ) in Neisseria gonorrhoeae is a serious public health problem , compromising the management and control of gonorrhoea globally .',
  'The antimicrobial resistance of Neisseria gonorrhoeae is a serious problem worldwide .',
  'Emergence of multidrug-resistant ( MDR ) and extensively drug-resistant ( XDR ) Neisseria gonorrhoeae is a serious concern and combination therapy has been recommended to delay the onset of treatment failures .',
  'Neisseria gonorrhoeae ( NG ) infection is a serious public health problem .',
  'Increasing rates of gonococcal ( GC ) infection and antimicrobial resistant ( AMR ) GC , are a serious public health concern for Canada and around the world .',
  'Gonococcal infections are now an uncommon problem in newborns in industrialized countries but remain a serious problem in developing countries due to ongoing high infection rates in pregnant women .',
  'The sexually transmitted disease , gonorrhea , is a serious health problem in developed as well as in developing countries , for which treatment continues to be a challenge .',
  'However , this has not become a serious problem to date , as large scale evaluation has shown that the quinolones remain highly efficacious for the treatment of gonorrhoea .'],
 'gonococcal': ['The occurrence of antibiotic resistant Neisseria gonorrhoeae isolates is a serious public health problem in different corners of the globe .',
  'The widespread antimicrobial resistance of Neisseria gonorrhoeae is a serious problem for the treatment and control of gonorrhoea .',
  'Antimicrobial resistance of Neisseria gonorrhoeae is a serious health problem in China .',
  'Gonorrhea in women : a serious health problem .',
  'Gonorrhoea is one of the most common sexually transmitted infections ( STIs ) in the world , and is a serious public health problem because of its associated morbidity and complications .',
  'Multidrug resistance is a serious problem that threatens the effective treatment of the widespread sexually transmitted disease gonorrhea , caused by the Gram-negative bacterium',
  'Antimicrobial resistance ( AMR ) in Neisseria gonorrhoeae is a serious public health problem , compromising the management and control of gonorrhoea globally .',
  'The antimicrobial resistance of Neisseria gonorrhoeae is a serious problem worldwide .',
  'Emergence of multidrug-resistant ( MDR ) and extensively drug-resistant ( XDR ) Neisseria gonorrhoeae is a serious concern and combination therapy has been recommended to delay the onset of treatment failures .',
  'Neisseria gonorrhoeae ( NG ) infection is a serious public health problem .',
  'Increasing rates of gonococcal ( GC ) infection and antimicrobial resistant ( AMR ) GC , are a serious public health concern for Canada and around the world .',
  'Gonococcal infections are now an uncommon problem in newborns in industrialized countries but remain a serious problem in developing countries due to ongoing high infection rates in pregnant women .',
  'The sexually transmitted disease , gonorrhea , is a serious health problem in developed as well as in developing countries , for which treatment continues to be a challenge .',
  'However , this has not become a serious problem to date , as large scale evaluation has shown that the quinolones remain highly efficacious for the treatment of gonorrhoea .'],
 'behavior': ['Self-injury is a severe behavioral problem commonly observed in institutionalized mentally retarded individuals .',
  'Using the Treatment Evaluation Inventory ( Kazdin , 1980a ) , staff members rated differential reinforcement of other behavior ( DRO ) , time-out , overcorrection , and contingent shock , each applied to a mild and a severe behavior problem .',
  'Self-injurious behavior ( SIB ) remains a severe and intractable abnormal behavior for nonhuman primates in diverse settings and is a significant concern for veterinarians and behavioral scientists .',
  'Self-injurious behavior ( SIB ) presents a serious problem in laboratory macaques that can not be socially housed for scientific reasons and among institutionalized children and adults where it is often associated with different forms of brain dysfunction .',
  'Self-injurious behavior is a serious problem that is not uncommon among individuals with mental retardation .',
  'Individuals with mild to moderate mental retardation living in community residential settings ( Experiment 1 ) or an institutional setting ( Experiment 2 ) rated the acceptability of differential reinforcement and time-out applied to a mild and a severe behavior problem .',
  'Self-injurious behavior ( SIB ) is a serious problem among the mentally handicapped and is often accompanied by other repetitive or stereotyped behaviors .',
  'Rumination is a serious problem demonstrated by some people with developmental disabilities , but previous research has not included a functional analysis and has rarely compared intervention methods during the assessment process .',
  'Self-injurious behavior ( SIB ) is a distressing type of problem behavior that may be exhibited in individuals with intellectual disabilities ( IDs ) .',
  'Self-injurious behaviour ( SIB ) is a devastating problem observed in individuals with various neurodevelopmental disorders , including specific genetic syndromes as well as idiopathic intellectual and developmental disability .',
  'Self-injurious behavior ( SIB ) is a serious and moderately prevalent problem behavior among developmentally disabled persons , and it frequently leads to treatment with psychotropic medication .'],
 'reinforcement': ['Self-injury is a severe behavioral problem commonly observed in institutionalized mentally retarded individuals .',
  'Using the Treatment Evaluation Inventory ( Kazdin , 1980a ) , staff members rated differential reinforcement of other behavior ( DRO ) , time-out , overcorrection , and contingent shock , each applied to a mild and a severe behavior problem .',
  'Self-injurious behavior ( SIB ) remains a severe and intractable abnormal behavior for nonhuman primates in diverse settings and is a significant concern for veterinarians and behavioral scientists .',
  'Self-injurious behavior ( SIB ) presents a serious problem in laboratory macaques that can not be socially housed for scientific reasons and among institutionalized children and adults where it is often associated with different forms of brain dysfunction .',
  'Self-injurious behavior is a serious problem that is not uncommon among individuals with mental retardation .',
  'Individuals with mild to moderate mental retardation living in community residential settings ( Experiment 1 ) or an institutional setting ( Experiment 2 ) rated the acceptability of differential reinforcement and time-out applied to a mild and a severe behavior problem .',
  'Self-injurious behavior ( SIB ) is a serious problem among the mentally handicapped and is often accompanied by other repetitive or stereotyped behaviors .',
  'Rumination is a serious problem demonstrated by some people with developmental disabilities , but previous research has not included a functional analysis and has rarely compared intervention methods during the assessment process .',
  'Self-injurious behavior ( SIB ) is a distressing type of problem behavior that may be exhibited in individuals with intellectual disabilities ( IDs ) .',
  'Self-injurious behaviour ( SIB ) is a devastating problem observed in individuals with various neurodevelopmental disorders , including specific genetic syndromes as well as idiopathic intellectual and developmental disability .',
  'Self-injurious behavior ( SIB ) is a serious and moderately prevalent problem behavior among developmentally disabled persons , and it frequently leads to treatment with psychotropic medication .'],
 'institutionalized': ['Self-injury is a severe behavioral problem commonly observed in institutionalized mentally retarded individuals .',
  'Using the Treatment Evaluation Inventory ( Kazdin , 1980a ) , staff members rated differential reinforcement of other behavior ( DRO ) , time-out , overcorrection , and contingent shock , each applied to a mild and a severe behavior problem .',
  'Self-injurious behavior ( SIB ) remains a severe and intractable abnormal behavior for nonhuman primates in diverse settings and is a significant concern for veterinarians and behavioral scientists .',
  'Self-injurious behavior ( SIB ) presents a serious problem in laboratory macaques that can not be socially housed for scientific reasons and among institutionalized children and adults where it is often associated with different forms of brain dysfunction .',
  'Self-injurious behavior is a serious problem that is not uncommon among individuals with mental retardation .',
  'Individuals with mild to moderate mental retardation living in community residential settings ( Experiment 1 ) or an institutional setting ( Experiment 2 ) rated the acceptability of differential reinforcement and time-out applied to a mild and a severe behavior problem .',
  'Self-injurious behavior ( SIB ) is a serious problem among the mentally handicapped and is often accompanied by other repetitive or stereotyped behaviors .',
  'Rumination is a serious problem demonstrated by some people with developmental disabilities , but previous research has not included a functional analysis and has rarely compared intervention methods during the assessment process .',
  'Self-injurious behavior ( SIB ) is a distressing type of problem behavior that may be exhibited in individuals with intellectual disabilities ( IDs ) .',
  'Self-injurious behaviour ( SIB ) is a devastating problem observed in individuals with various neurodevelopmental disorders , including specific genetic syndromes as well as idiopathic intellectual and developmental disability .',
  'Self-injurious behavior ( SIB ) is a serious and moderately prevalent problem behavior among developmentally disabled persons , and it frequently leads to treatment with psychotropic medication .'],
 'chromium': ['Chromium contamination of agronomic soil has to turn into a serious global problem .',
  'Chromium ( Cr ) contamination in farmlands has become a serious environmental concern due to the excessive use of industrial wastewater as an irrigation source .',
  'The presence of hexavalent chromium ( Cr[VI ] ) , which is carcinogenic to humans and a dermal sensitizer , in tattoo inks may represent a serious health concern .',
  'Environmental contamination by hexavalent chromium , Cr(VI ) , presents a serious public health problem .',
  'Cr(VI ) exposure in the workplace remains a serious problem as a cause of lung cancer and cancers of nose and nasal cavity , especially in relatively small enterprises that use chromium compounds .',
  'Water pollution caused by Cr(III ) is a serious environmental problem which bring adverse effect to environmental protection and public safety .',
  'Hexavalent chromium contamination is a serious problem due to its high toxicity and carcinogenic effects on the biological systems .',
  'Chromium ( Cr ) contamination in rice imposes a serious concern to human health as rice is used as staple food throughout the world .',
  'Contaminated water with hexavalent chromium Cr(VI ) is a serious environmental problem .',
  'Chromium pollution of soil and water is a serious environmental concern due to potential carcinogenicity of hexavalent chromium [ Cr(VI ) ] when ingested .',
  'Since chromium is known for its toxicity , the disposal of chrome shavings has been identified as a serious problem from the environmental point of view .',
  'Chromium contamination of soil and water is a serious environmental and public health concern as the hexavalent form of chromium [ Cr(VI ) ] is readily soluble in water and is a confirmed carcinogen .',
  'Chromium pollution is a serious environmental problem with few cost-effective remediation strategies available .',
  'While reduction of Cr(VI ) to Cr(III ) is dominant in these anoxic sediments , the potential of Cr(III ) oxidation and Cr(VI ) reoccurrence during sediment resuspension and oxygenation resulting from dredging , bioturbation , and flood events poses a serious concern .',
  'Hexavalent chromium ( Cr(VI ) ) pollution is a severe public health problem in the world .',
  'Environmental contamination by hexavalent chromium , Cr(VI ) , presents a serious public health problem .',
  'Chromate is considered as a serious environmental problem due its toxicity .',
  'Widespread contamination of water and soil by Cr(VI ) present a serious public health problem .'],
 'cr': ['Chromium contamination of agronomic soil has to turn into a serious global problem .',
  'Chromium ( Cr ) contamination in farmlands has become a serious environmental concern due to the excessive use of industrial wastewater as an irrigation source .',
  'The presence of hexavalent chromium ( Cr[VI ] ) , which is carcinogenic to humans and a dermal sensitizer , in tattoo inks may represent a serious health concern .',
  'Environmental contamination by hexavalent chromium , Cr(VI ) , presents a serious public health problem .',
  'Cr(VI ) exposure in the workplace remains a serious problem as a cause of lung cancer and cancers of nose and nasal cavity , especially in relatively small enterprises that use chromium compounds .',
  'Water pollution caused by Cr(III ) is a serious environmental problem which bring adverse effect to environmental protection and public safety .',
  'Hexavalent chromium contamination is a serious problem due to its high toxicity and carcinogenic effects on the biological systems .',
  'Chromium ( Cr ) contamination in rice imposes a serious concern to human health as rice is used as staple food throughout the world .',
  'Contaminated water with hexavalent chromium Cr(VI ) is a serious environmental problem .',
  'Chromium pollution of soil and water is a serious environmental concern due to potential carcinogenicity of hexavalent chromium [ Cr(VI ) ] when ingested .',
  'Since chromium is known for its toxicity , the disposal of chrome shavings has been identified as a serious problem from the environmental point of view .',
  'Chromium contamination of soil and water is a serious environmental and public health concern as the hexavalent form of chromium [ Cr(VI ) ] is readily soluble in water and is a confirmed carcinogen .',
  'Chromium pollution is a serious environmental problem with few cost-effective remediation strategies available .',
  'While reduction of Cr(VI ) to Cr(III ) is dominant in these anoxic sediments , the potential of Cr(III ) oxidation and Cr(VI ) reoccurrence during sediment resuspension and oxygenation resulting from dredging , bioturbation , and flood events poses a serious concern .',
  'Hexavalent chromium ( Cr(VI ) ) pollution is a severe public health problem in the world .',
  'Environmental contamination by hexavalent chromium , Cr(VI ) , presents a serious public health problem .',
  'Chromate is considered as a serious environmental problem due its toxicity .',
  'Widespread contamination of water and soil by Cr(VI ) present a serious public health problem .'],
 'hexavalent': ['Chromium contamination of agronomic soil has to turn into a serious global problem .',
  'Chromium ( Cr ) contamination in farmlands has become a serious environmental concern due to the excessive use of industrial wastewater as an irrigation source .',
  'The presence of hexavalent chromium ( Cr[VI ] ) , which is carcinogenic to humans and a dermal sensitizer , in tattoo inks may represent a serious health concern .',
  'Environmental contamination by hexavalent chromium , Cr(VI ) , presents a serious public health problem .',
  'Cr(VI ) exposure in the workplace remains a serious problem as a cause of lung cancer and cancers of nose and nasal cavity , especially in relatively small enterprises that use chromium compounds .',
  'Water pollution caused by Cr(III ) is a serious environmental problem which bring adverse effect to environmental protection and public safety .',
  'Hexavalent chromium contamination is a serious problem due to its high toxicity and carcinogenic effects on the biological systems .',
  'Chromium ( Cr ) contamination in rice imposes a serious concern to human health as rice is used as staple food throughout the world .',
  'Contaminated water with hexavalent chromium Cr(VI ) is a serious environmental problem .',
  'Chromium pollution of soil and water is a serious environmental concern due to potential carcinogenicity of hexavalent chromium [ Cr(VI ) ] when ingested .',
  'Since chromium is known for its toxicity , the disposal of chrome shavings has been identified as a serious problem from the environmental point of view .',
  'Chromium contamination of soil and water is a serious environmental and public health concern as the hexavalent form of chromium [ Cr(VI ) ] is readily soluble in water and is a confirmed carcinogen .',
  'Chromium pollution is a serious environmental problem with few cost-effective remediation strategies available .',
  'While reduction of Cr(VI ) to Cr(III ) is dominant in these anoxic sediments , the potential of Cr(III ) oxidation and Cr(VI ) reoccurrence during sediment resuspension and oxygenation resulting from dredging , bioturbation , and flood events poses a serious concern .',
  'Hexavalent chromium ( Cr(VI ) ) pollution is a severe public health problem in the world .',
  'Environmental contamination by hexavalent chromium , Cr(VI ) , presents a serious public health problem .',
  'Chromate is considered as a serious environmental problem due its toxicity .',
  'Widespread contamination of water and soil by Cr(VI ) present a serious public health problem .'],
 'salinity': ['High salinity soils inhibit crop production worldwide and represent a serious agricultural problem .',
  'Increased salinity in rivers and streams is a serious environmental concern , and in Australia there is growing information about the acute tolerances to salinity for freshwater macroinvertebrates , but much less information about chronic and sub-lethal tolerances .',
  'Soil salinization induced by the dual effects of natural environment and human activities is a serious ecological problem globally .',
  'Combined stress of salinity and heavy metal is a serious problem for crop production ; however , physiological mechanisms of tolerance to such condition remain elusive in cotton .',
  'Soil salinization is a serious and growing problem around the world .',
  'The proposed methodology is demonstrated for an example at the Upper Colorado River Basin ( UCRB ) , where salinity is a serious concern .',
  'Soil salinization is a serious problem that affects the seedling growth in many regions .',
  'Soil salinity is a serious problem worldwide that reduces agricultural productivity .',
  'Salinity is a serious environmental problem .',
  'Salinity represents a serious problem in the Mediterranean region .',
  'Soil salinity accumulation is strong in arid areas and it has become a serious environmental problem .',
  'Since A. donax is a high-yield biomass crop , reduction of biomass might be a serious agronomical problem in saline conditions .',
  'A rise in [Ca2+]i may be a serious problem for plants in microgravity environment .',
  'Soil salinization is a serious problem for cultivation of rice , as among cereals rice is the most salt sensitive crop , and more than 40 % of the total agricultural land amounting to approximately 80 million ha the world over is salt affected .',
  'Salinity is one of the most widespread agricultural problems in arid and semi-arid regions that makes fields unproductive , and soil salinization is a serious problem in the entire world .',
  'Salt stress has become a severe global problem , and salinity is one of the most important abiotic factors limiting plant growth and yield .'],
 'salinization': ['High salinity soils inhibit crop production worldwide and represent a serious agricultural problem .',
  'Increased salinity in rivers and streams is a serious environmental concern , and in Australia there is growing information about the acute tolerances to salinity for freshwater macroinvertebrates , but much less information about chronic and sub-lethal tolerances .',
  'Soil salinization induced by the dual effects of natural environment and human activities is a serious ecological problem globally .',
  'Combined stress of salinity and heavy metal is a serious problem for crop production ; however , physiological mechanisms of tolerance to such condition remain elusive in cotton .',
  'Soil salinization is a serious and growing problem around the world .',
  'The proposed methodology is demonstrated for an example at the Upper Colorado River Basin ( UCRB ) , where salinity is a serious concern .',
  'Soil salinization is a serious problem that affects the seedling growth in many regions .',
  'Soil salinity is a serious problem worldwide that reduces agricultural productivity .',
  'Salinity is a serious environmental problem .',
  'Salinity represents a serious problem in the Mediterranean region .',
  'Soil salinity accumulation is strong in arid areas and it has become a serious environmental problem .',
  'Since A. donax is a high-yield biomass crop , reduction of biomass might be a serious agronomical problem in saline conditions .',
  'A rise in [Ca2+]i may be a serious problem for plants in microgravity environment .',
  'Soil salinization is a serious problem for cultivation of rice , as among cereals rice is the most salt sensitive crop , and more than 40 % of the total agricultural land amounting to approximately 80 million ha the world over is salt affected .',
  'Salinity is one of the most widespread agricultural problems in arid and semi-arid regions that makes fields unproductive , and soil salinization is a serious problem in the entire world .',
  'Salt stress has become a severe global problem , and salinity is one of the most important abiotic factors limiting plant growth and yield .'],
 'salt': ['High salinity soils inhibit crop production worldwide and represent a serious agricultural problem .',
  'Increased salinity in rivers and streams is a serious environmental concern , and in Australia there is growing information about the acute tolerances to salinity for freshwater macroinvertebrates , but much less information about chronic and sub-lethal tolerances .',
  'Soil salinization induced by the dual effects of natural environment and human activities is a serious ecological problem globally .',
  'Combined stress of salinity and heavy metal is a serious problem for crop production ; however , physiological mechanisms of tolerance to such condition remain elusive in cotton .',
  'Soil salinization is a serious and growing problem around the world .',
  'The proposed methodology is demonstrated for an example at the Upper Colorado River Basin ( UCRB ) , where salinity is a serious concern .',
  'Soil salinization is a serious problem that affects the seedling growth in many regions .',
  'Soil salinity is a serious problem worldwide that reduces agricultural productivity .',
  'Salinity is a serious environmental problem .',
  'Salinity represents a serious problem in the Mediterranean region .',
  'Soil salinity accumulation is strong in arid areas and it has become a serious environmental problem .',
  'Since A. donax is a high-yield biomass crop , reduction of biomass might be a serious agronomical problem in saline conditions .',
  'A rise in [Ca2+]i may be a serious problem for plants in microgravity environment .',
  'Soil salinization is a serious problem for cultivation of rice , as among cereals rice is the most salt sensitive crop , and more than 40 % of the total agricultural land amounting to approximately 80 million ha the world over is salt affected .',
  'Salinity is one of the most widespread agricultural problems in arid and semi-arid regions that makes fields unproductive , and soil salinization is a serious problem in the entire world .',
  'Salt stress has become a severe global problem , and salinity is one of the most important abiotic factors limiting plant growth and yield .'],
 'arid': ['High salinity soils inhibit crop production worldwide and represent a serious agricultural problem .',
  'Increased salinity in rivers and streams is a serious environmental concern , and in Australia there is growing information about the acute tolerances to salinity for freshwater macroinvertebrates , but much less information about chronic and sub-lethal tolerances .',
  'Soil salinization induced by the dual effects of natural environment and human activities is a serious ecological problem globally .',
  'Combined stress of salinity and heavy metal is a serious problem for crop production ; however , physiological mechanisms of tolerance to such condition remain elusive in cotton .',
  'Soil salinization is a serious and growing problem around the world .',
  'The proposed methodology is demonstrated for an example at the Upper Colorado River Basin ( UCRB ) , where salinity is a serious concern .',
  'Soil salinization is a serious problem that affects the seedling growth in many regions .',
  'Soil salinity is a serious problem worldwide that reduces agricultural productivity .',
  'Salinity is a serious environmental problem .',
  'Salinity represents a serious problem in the Mediterranean region .',
  'Soil salinity accumulation is strong in arid areas and it has become a serious environmental problem .',
  'Since A. donax is a high-yield biomass crop , reduction of biomass might be a serious agronomical problem in saline conditions .',
  'A rise in [Ca2+]i may be a serious problem for plants in microgravity environment .',
  'Soil salinization is a serious problem for cultivation of rice , as among cereals rice is the most salt sensitive crop , and more than 40 % of the total agricultural land amounting to approximately 80 million ha the world over is salt affected .',
  'Salinity is one of the most widespread agricultural problems in arid and semi-arid regions that makes fields unproductive , and soil salinization is a serious problem in the entire world .',
  'Salt stress has become a severe global problem , and salinity is one of the most important abiotic factors limiting plant growth and yield .'],
 'fibrosis': ['Idiopathic pulmonary fibrosis ( IPF ) is a fatal growing problem , with limited therapeutic options .',
  'Pulmonary fibrosis is a vexing clinical problem with no proven therapeutic options .',
  'Fibrosis is also a serious cosmetic problem for patients , and in some cases it can also imply pain .',
  'Pulmonary fibrosis is a progressively aggravating lethal disease that is a serious public health concern .',
  'Drug-induced interstitial lung disease ( ILD ) , particularly pulmonary fibrosis , is a serious clinical concern and myofibroblasts have been suggested to have a major role , with it recently being revealed that some of these myofibroblasts are derived from lung epithelial cells through epithelial-mesenchymal transition ( EMT ) .',
  'Fibrosis is a serious health problem often leading to accompanying organ failure .',
  'The results suggested that chronic airway inflammation in ICS is not such a serious problem compared with DPB and BE .',
  'Multi-cause-induced interstitial lung disease , particularly pulmonary fibrosis , is a serious clinical concern .',
  'Idiopathic pulmonary fibrosis ( IPF ) is a serious lung problem with advancing and diffusive pulmonary fibrosis as the pathologic basis , and with oxidative stress and inflammation as the key pathogenesis .',
  'Pulmonary fibrosis remains a serious biomedical problem with no cure and an urgent need for better therapies .',
  'Fibrosis is a severe and progressive sequel of many pulmonary diseases , has no effective therapy at present and , consequently , represents a serious health problem .'],
 'ipf': ['Idiopathic pulmonary fibrosis ( IPF ) is a fatal growing problem , with limited therapeutic options .',
  'Pulmonary fibrosis is a vexing clinical problem with no proven therapeutic options .',
  'Fibrosis is also a serious cosmetic problem for patients , and in some cases it can also imply pain .',
  'Pulmonary fibrosis is a progressively aggravating lethal disease that is a serious public health concern .',
  'Drug-induced interstitial lung disease ( ILD ) , particularly pulmonary fibrosis , is a serious clinical concern and myofibroblasts have been suggested to have a major role , with it recently being revealed that some of these myofibroblasts are derived from lung epithelial cells through epithelial-mesenchymal transition ( EMT ) .',
  'Fibrosis is a serious health problem often leading to accompanying organ failure .',
  'The results suggested that chronic airway inflammation in ICS is not such a serious problem compared with DPB and BE .',
  'Multi-cause-induced interstitial lung disease , particularly pulmonary fibrosis , is a serious clinical concern .',
  'Idiopathic pulmonary fibrosis ( IPF ) is a serious lung problem with advancing and diffusive pulmonary fibrosis as the pathologic basis , and with oxidative stress and inflammation as the key pathogenesis .',
  'Pulmonary fibrosis remains a serious biomedical problem with no cure and an urgent need for better therapies .',
  'Fibrosis is a severe and progressive sequel of many pulmonary diseases , has no effective therapy at present and , consequently , represents a serious health problem .'],
 'myofibroblasts': ['Idiopathic pulmonary fibrosis ( IPF ) is a fatal growing problem , with limited therapeutic options .',
  'Pulmonary fibrosis is a vexing clinical problem with no proven therapeutic options .',
  'Fibrosis is also a serious cosmetic problem for patients , and in some cases it can also imply pain .',
  'Pulmonary fibrosis is a progressively aggravating lethal disease that is a serious public health concern .',
  'Drug-induced interstitial lung disease ( ILD ) , particularly pulmonary fibrosis , is a serious clinical concern and myofibroblasts have been suggested to have a major role , with it recently being revealed that some of these myofibroblasts are derived from lung epithelial cells through epithelial-mesenchymal transition ( EMT ) .',
  'Fibrosis is a serious health problem often leading to accompanying organ failure .',
  'The results suggested that chronic airway inflammation in ICS is not such a serious problem compared with DPB and BE .',
  'Multi-cause-induced interstitial lung disease , particularly pulmonary fibrosis , is a serious clinical concern .',
  'Idiopathic pulmonary fibrosis ( IPF ) is a serious lung problem with advancing and diffusive pulmonary fibrosis as the pathologic basis , and with oxidative stress and inflammation as the key pathogenesis .',
  'Pulmonary fibrosis remains a serious biomedical problem with no cure and an urgent need for better therapies .',
  'Fibrosis is a severe and progressive sequel of many pulmonary diseases , has no effective therapy at present and , consequently , represents a serious health problem .'],
 'idiopathic': ['Idiopathic pulmonary fibrosis ( IPF ) is a fatal growing problem , with limited therapeutic options .',
  'Pulmonary fibrosis is a vexing clinical problem with no proven therapeutic options .',
  'Fibrosis is also a serious cosmetic problem for patients , and in some cases it can also imply pain .',
  'Pulmonary fibrosis is a progressively aggravating lethal disease that is a serious public health concern .',
  'Drug-induced interstitial lung disease ( ILD ) , particularly pulmonary fibrosis , is a serious clinical concern and myofibroblasts have been suggested to have a major role , with it recently being revealed that some of these myofibroblasts are derived from lung epithelial cells through epithelial-mesenchymal transition ( EMT ) .',
  'Fibrosis is a serious health problem often leading to accompanying organ failure .',
  'The results suggested that chronic airway inflammation in ICS is not such a serious problem compared with DPB and BE .',
  'Multi-cause-induced interstitial lung disease , particularly pulmonary fibrosis , is a serious clinical concern .',
  'Idiopathic pulmonary fibrosis ( IPF ) is a serious lung problem with advancing and diffusive pulmonary fibrosis as the pathologic basis , and with oxidative stress and inflammation as the key pathogenesis .',
  'Pulmonary fibrosis remains a serious biomedical problem with no cure and an urgent need for better therapies .',
  'Fibrosis is a severe and progressive sequel of many pulmonary diseases , has no effective therapy at present and , consequently , represents a serious health problem .'],
 'epithelial': ['Idiopathic pulmonary fibrosis ( IPF ) is a fatal growing problem , with limited therapeutic options .',
  'Pulmonary fibrosis is a vexing clinical problem with no proven therapeutic options .',
  'Fibrosis is also a serious cosmetic problem for patients , and in some cases it can also imply pain .',
  'Pulmonary fibrosis is a progressively aggravating lethal disease that is a serious public health concern .',
  'Drug-induced interstitial lung disease ( ILD ) , particularly pulmonary fibrosis , is a serious clinical concern and myofibroblasts have been suggested to have a major role , with it recently being revealed that some of these myofibroblasts are derived from lung epithelial cells through epithelial-mesenchymal transition ( EMT ) .',
  'Fibrosis is a serious health problem often leading to accompanying organ failure .',
  'The results suggested that chronic airway inflammation in ICS is not such a serious problem compared with DPB and BE .',
  'Multi-cause-induced interstitial lung disease , particularly pulmonary fibrosis , is a serious clinical concern .',
  'Idiopathic pulmonary fibrosis ( IPF ) is a serious lung problem with advancing and diffusive pulmonary fibrosis as the pathologic basis , and with oxidative stress and inflammation as the key pathogenesis .',
  'Pulmonary fibrosis remains a serious biomedical problem with no cure and an urgent need for better therapies .',
  'Fibrosis is a severe and progressive sequel of many pulmonary diseases , has no effective therapy at present and , consequently , represents a serious health problem .'],
 'intimate': ['Intimate partner violence has long been recognized as a serious public health problem .',
  "Intimate partner violence is a serious and pervasive social problem with deleterious consequences for survivors ' well-being .",
  "Intimate partner violence is a serious global public health problem particularly in low-and middle-income countries such as Ethiopia where women 's empowerment is limited .",
  'Partner violence is a serious public health problem , due to their potential short- , medium- or long-term physical and psychological consequences .',
  'Intimate partner violence is a preventable public health problem .',
  'Intimate partner violence is a preventable health problem that affects more than 12 million people in the United States each year .',
  'Intimate partner violence is a serious and pervasive problem in U.S. society , with 25 % of women and 7.6 % of men reporting physical abuse by an intimate partner each year .',
  'Intimate partner violence constitutes a serious health problem worldwide .',
  'Intimate partner violence is a serious social problem and public health issue affecting the well-being of the young adults .',
  'Intimate partner violence is a serious public health concern in the United States .',
  'Intimate partner violence is a serious public health problem accompanied by substantial morbidity and mortality .'],
 'honey': ['Assessing the authenticity of honey is a serious problem that has gained much interest internationally because honey has frequently been subject to various fraudulent practices , including mislabelling of botanical and geographical origin and mixing with sugar syrups or honey of lower quality .',
  'The honeybee disease American foulbrood ( AFB ) is a serious problem since its causative agent ( Paenibacillus larvae ) has become increasingly resistant to conventional antibiotics .',
  'Losses raise a serious concern , because bees have an indispensable role in the food supply of humankind .',
  'A serious allergic reaction after an insect sting is wellknown source for concern and anxiety .',
  'Bee disease caused by spore-forming Paenibacillus larvae and Paenibacillus alvei is a serious problem for honey production .',
  'The honey bee disease American foulbrood ( AFB ) is a serious problem since its causative agent ( Paenibacillus larvae ) has become increasingly resistant to conventional antibiotics .',
  'Honey bee mortality is a serious problem that beekeepers in Argentina have had to face during the last 3 years .',
  'The honeybee disease nosemosis type C is a serious problem since its causative agent , microsporidium Nosema ceranae , is widespread among adult honey bees .',
  'Honeybee mortality is a serious problem that beekeepers in Argentina have had to face during the last 3 years .',
  'Ants , bees , hornets , wasps , and yellow jackets ( insects in Order Hymenoptera ) are potentially a serious concern to outdoor workers , as the venom from their stings can cause life-threatening allergic reactions .',
  'During the last years , honey bee mortality became a serious problem for Argentinean beekeepers .',
  'Honeybee stings are a severe public health problem .',
  'The American foulbrood disease is widely distributed all over the world and causes a serious problem for the honeybee industry .',
  'If found to be beneficial , honey could provide a simple , elegant and cost-effective solution to a troublesome health problem , thus benefiting a large number of patients .',
  'The ongoing decline of honey bee health worldwide is a serious economic and ecological concern .',
  'Due to the high impact of honey bees on ecology and economy this epizootic is a severe and pressing problem .'],
 'honeybee': ['Assessing the authenticity of honey is a serious problem that has gained much interest internationally because honey has frequently been subject to various fraudulent practices , including mislabelling of botanical and geographical origin and mixing with sugar syrups or honey of lower quality .',
  'The honeybee disease American foulbrood ( AFB ) is a serious problem since its causative agent ( Paenibacillus larvae ) has become increasingly resistant to conventional antibiotics .',
  'Losses raise a serious concern , because bees have an indispensable role in the food supply of humankind .',
  'A serious allergic reaction after an insect sting is wellknown source for concern and anxiety .',
  'Bee disease caused by spore-forming Paenibacillus larvae and Paenibacillus alvei is a serious problem for honey production .',
  'The honey bee disease American foulbrood ( AFB ) is a serious problem since its causative agent ( Paenibacillus larvae ) has become increasingly resistant to conventional antibiotics .',
  'Honey bee mortality is a serious problem that beekeepers in Argentina have had to face during the last 3 years .',
  'The honeybee disease nosemosis type C is a serious problem since its causative agent , microsporidium Nosema ceranae , is widespread among adult honey bees .',
  'Honeybee mortality is a serious problem that beekeepers in Argentina have had to face during the last 3 years .',
  'Ants , bees , hornets , wasps , and yellow jackets ( insects in Order Hymenoptera ) are potentially a serious concern to outdoor workers , as the venom from their stings can cause life-threatening allergic reactions .',
  'During the last years , honey bee mortality became a serious problem for Argentinean beekeepers .',
  'Honeybee stings are a severe public health problem .',
  'The American foulbrood disease is widely distributed all over the world and causes a serious problem for the honeybee industry .',
  'If found to be beneficial , honey could provide a simple , elegant and cost-effective solution to a troublesome health problem , thus benefiting a large number of patients .',
  'The ongoing decline of honey bee health worldwide is a serious economic and ecological concern .',
  'Due to the high impact of honey bees on ecology and economy this epizootic is a severe and pressing problem .'],
 'bee': ['Assessing the authenticity of honey is a serious problem that has gained much interest internationally because honey has frequently been subject to various fraudulent practices , including mislabelling of botanical and geographical origin and mixing with sugar syrups or honey of lower quality .',
  'The honeybee disease American foulbrood ( AFB ) is a serious problem since its causative agent ( Paenibacillus larvae ) has become increasingly resistant to conventional antibiotics .',
  'Losses raise a serious concern , because bees have an indispensable role in the food supply of humankind .',
  'A serious allergic reaction after an insect sting is wellknown source for concern and anxiety .',
  'Bee disease caused by spore-forming Paenibacillus larvae and Paenibacillus alvei is a serious problem for honey production .',
  'The honey bee disease American foulbrood ( AFB ) is a serious problem since its causative agent ( Paenibacillus larvae ) has become increasingly resistant to conventional antibiotics .',
  'Honey bee mortality is a serious problem that beekeepers in Argentina have had to face during the last 3 years .',
  'The honeybee disease nosemosis type C is a serious problem since its causative agent , microsporidium Nosema ceranae , is widespread among adult honey bees .',
  'Honeybee mortality is a serious problem that beekeepers in Argentina have had to face during the last 3 years .',
  'Ants , bees , hornets , wasps , and yellow jackets ( insects in Order Hymenoptera ) are potentially a serious concern to outdoor workers , as the venom from their stings can cause life-threatening allergic reactions .',
  'During the last years , honey bee mortality became a serious problem for Argentinean beekeepers .',
  'Honeybee stings are a severe public health problem .',
  'The American foulbrood disease is widely distributed all over the world and causes a serious problem for the honeybee industry .',
  'If found to be beneficial , honey could provide a simple , elegant and cost-effective solution to a troublesome health problem , thus benefiting a large number of patients .',
  'The ongoing decline of honey bee health worldwide is a serious economic and ecological concern .',
  'Due to the high impact of honey bees on ecology and economy this epizootic is a severe and pressing problem .'],
 'bees': ['Assessing the authenticity of honey is a serious problem that has gained much interest internationally because honey has frequently been subject to various fraudulent practices , including mislabelling of botanical and geographical origin and mixing with sugar syrups or honey of lower quality .',
  'The honeybee disease American foulbrood ( AFB ) is a serious problem since its causative agent ( Paenibacillus larvae ) has become increasingly resistant to conventional antibiotics .',
  'Losses raise a serious concern , because bees have an indispensable role in the food supply of humankind .',
  'A serious allergic reaction after an insect sting is wellknown source for concern and anxiety .',
  'Bee disease caused by spore-forming Paenibacillus larvae and Paenibacillus alvei is a serious problem for honey production .',
  'The honey bee disease American foulbrood ( AFB ) is a serious problem since its causative agent ( Paenibacillus larvae ) has become increasingly resistant to conventional antibiotics .',
  'Honey bee mortality is a serious problem that beekeepers in Argentina have had to face during the last 3 years .',
  'The honeybee disease nosemosis type C is a serious problem since its causative agent , microsporidium Nosema ceranae , is widespread among adult honey bees .',
  'Honeybee mortality is a serious problem that beekeepers in Argentina have had to face during the last 3 years .',
  'Ants , bees , hornets , wasps , and yellow jackets ( insects in Order Hymenoptera ) are potentially a serious concern to outdoor workers , as the venom from their stings can cause life-threatening allergic reactions .',
  'During the last years , honey bee mortality became a serious problem for Argentinean beekeepers .',
  'Honeybee stings are a severe public health problem .',
  'The American foulbrood disease is widely distributed all over the world and causes a serious problem for the honeybee industry .',
  'If found to be beneficial , honey could provide a simple , elegant and cost-effective solution to a troublesome health problem , thus benefiting a large number of patients .',
  'The ongoing decline of honey bee health worldwide is a serious economic and ecological concern .',
  'Due to the high impact of honey bees on ecology and economy this epizootic is a severe and pressing problem .'],
 'beekeepers': ['Assessing the authenticity of honey is a serious problem that has gained much interest internationally because honey has frequently been subject to various fraudulent practices , including mislabelling of botanical and geographical origin and mixing with sugar syrups or honey of lower quality .',
  'The honeybee disease American foulbrood ( AFB ) is a serious problem since its causative agent ( Paenibacillus larvae ) has become increasingly resistant to conventional antibiotics .',
  'Losses raise a serious concern , because bees have an indispensable role in the food supply of humankind .',
  'A serious allergic reaction after an insect sting is wellknown source for concern and anxiety .',
  'Bee disease caused by spore-forming Paenibacillus larvae and Paenibacillus alvei is a serious problem for honey production .',
  'The honey bee disease American foulbrood ( AFB ) is a serious problem since its causative agent ( Paenibacillus larvae ) has become increasingly resistant to conventional antibiotics .',
  'Honey bee mortality is a serious problem that beekeepers in Argentina have had to face during the last 3 years .',
  'The honeybee disease nosemosis type C is a serious problem since its causative agent , microsporidium Nosema ceranae , is widespread among adult honey bees .',
  'Honeybee mortality is a serious problem that beekeepers in Argentina have had to face during the last 3 years .',
  'Ants , bees , hornets , wasps , and yellow jackets ( insects in Order Hymenoptera ) are potentially a serious concern to outdoor workers , as the venom from their stings can cause life-threatening allergic reactions .',
  'During the last years , honey bee mortality became a serious problem for Argentinean beekeepers .',
  'Honeybee stings are a severe public health problem .',
  'The American foulbrood disease is widely distributed all over the world and causes a serious problem for the honeybee industry .',
  'If found to be beneficial , honey could provide a simple , elegant and cost-effective solution to a troublesome health problem , thus benefiting a large number of patients .',
  'The ongoing decline of honey bee health worldwide is a serious economic and ecological concern .',
  'Due to the high impact of honey bees on ecology and economy this epizootic is a severe and pressing problem .'],
 'larvae': ['Assessing the authenticity of honey is a serious problem that has gained much interest internationally because honey has frequently been subject to various fraudulent practices , including mislabelling of botanical and geographical origin and mixing with sugar syrups or honey of lower quality .',
  'The honeybee disease American foulbrood ( AFB ) is a serious problem since its causative agent ( Paenibacillus larvae ) has become increasingly resistant to conventional antibiotics .',
  'Losses raise a serious concern , because bees have an indispensable role in the food supply of humankind .',
  'A serious allergic reaction after an insect sting is wellknown source for concern and anxiety .',
  'Bee disease caused by spore-forming Paenibacillus larvae and Paenibacillus alvei is a serious problem for honey production .',
  'The honey bee disease American foulbrood ( AFB ) is a serious problem since its causative agent ( Paenibacillus larvae ) has become increasingly resistant to conventional antibiotics .',
  'Honey bee mortality is a serious problem that beekeepers in Argentina have had to face during the last 3 years .',
  'The honeybee disease nosemosis type C is a serious problem since its causative agent , microsporidium Nosema ceranae , is widespread among adult honey bees .',
  'Honeybee mortality is a serious problem that beekeepers in Argentina have had to face during the last 3 years .',
  'Ants , bees , hornets , wasps , and yellow jackets ( insects in Order Hymenoptera ) are potentially a serious concern to outdoor workers , as the venom from their stings can cause life-threatening allergic reactions .',
  'During the last years , honey bee mortality became a serious problem for Argentinean beekeepers .',
  'Honeybee stings are a severe public health problem .',
  'The American foulbrood disease is widely distributed all over the world and causes a serious problem for the honeybee industry .',
  'If found to be beneficial , honey could provide a simple , elegant and cost-effective solution to a troublesome health problem , thus benefiting a large number of patients .',
  'The ongoing decline of honey bee health worldwide is a serious economic and ecological concern .',
  'Due to the high impact of honey bees on ecology and economy this epizootic is a severe and pressing problem .'],
 'mexico': ['Diabetes has emerged as a serious health problem in the Navajo nation , the largest Indigenous tribe in the US .',
  'The diabetes epidemic remains a serious problem in this First Nation community .',
  'Youth-onset type 2 diabetes is a serious public health problem for Indigenous people throughout the world .',
  'Diabetes in Mexico -- a serious and growing problem .',
  'Diabetes is a serious public health problem in the border region between the United States of America and Mexico , reflecting and by some measures surpassing the extent of national diabetes burden of each country .',
  'Gestational Diabetes Mellitus ( GDM ) is a serious health concern for pregnant women , with Hispanic women at particular risk for developing the condition .',
  'The increase in the prevalence of diabetes has become a severe problem around the world ; mainly affecting indigenous communities as the Mayan of Yucatán in Mexico .',
  'Diabetes in pregnant Mexican-American women is a serious and expensive health problem .',
  'There is a serious gap in the official epidemiological information ; placing the real problem in perspective would help to establish the adequate public policies for both , prevention and investigation of the causes of SD in Mexico .',
  'There is a serious gap in the official epidemiological information ; placing the real problem in perspective would help to establish the adequate public policies for both , prevention and investigation of the causes of SD in Mexico .',
  'In Mexico , diabetes represents a serious public health problem and a high-cost disease for the health system .',
  'Non-insulin-dependent diabetes mellitus ( NIDDM ) is a serious health problem among the Zuni Indians of New Mexico .',
  'The growing incidence of diabetes among Hispanics is a serious public health concern .',
  'Diabetes mellitus is a severe health problem in Mexico , and its prevalence is increasing exponentially every year .'],
 'indigenous': ['Diabetes has emerged as a serious health problem in the Navajo nation , the largest Indigenous tribe in the US .',
  'The diabetes epidemic remains a serious problem in this First Nation community .',
  'Youth-onset type 2 diabetes is a serious public health problem for Indigenous people throughout the world .',
  'Diabetes in Mexico -- a serious and growing problem .',
  'Diabetes is a serious public health problem in the border region between the United States of America and Mexico , reflecting and by some measures surpassing the extent of national diabetes burden of each country .',
  'Gestational Diabetes Mellitus ( GDM ) is a serious health concern for pregnant women , with Hispanic women at particular risk for developing the condition .',
  'The increase in the prevalence of diabetes has become a severe problem around the world ; mainly affecting indigenous communities as the Mayan of Yucatán in Mexico .',
  'Diabetes in pregnant Mexican-American women is a serious and expensive health problem .',
  'There is a serious gap in the official epidemiological information ; placing the real problem in perspective would help to establish the adequate public policies for both , prevention and investigation of the causes of SD in Mexico .',
  'There is a serious gap in the official epidemiological information ; placing the real problem in perspective would help to establish the adequate public policies for both , prevention and investigation of the causes of SD in Mexico .',
  'In Mexico , diabetes represents a serious public health problem and a high-cost disease for the health system .',
  'Non-insulin-dependent diabetes mellitus ( NIDDM ) is a serious health problem among the Zuni Indians of New Mexico .',
  'The growing incidence of diabetes among Hispanics is a serious public health concern .',
  'Diabetes mellitus is a severe health problem in Mexico , and its prevalence is increasing exponentially every year .'],
 'hev': ['Hepatitis E virus ( HEV ) infection is a serious public health concern in developing countries .',
  'Hepatitis E virus ( HEV ) infection is a serious health problem in developing countries and is also increasingly reported in industrialized regions .',
  'The hepatitis E virus causes acute viral hepatitis endemic in much of the developing world and is a serious public health problem .',
  'Hepatitis E ( HE ) is a serious problem in developing countries worldwide , affecting in epidemics or as sporadic cases millions of people .',
  'Hepatitis E virus-mediated infection is a serious public health concern in economically developing nations of the world .',
  'Hepatitis E caused by hepatitis E virus ( HEV ) is a serious public health concern in developing countries where HEV is mainly transmitted through contaminated water .',
  'Hepatitis E virus ( HEV ) is a serious public health problem that causes acute hepatitis in humans and is primarily transmitted through fecal and oral routes .',
  'Hepatitis E is a serious public health problem in developing countries .',
  'Hepatitis E virus has emerged as a serious problem after solid organ transplantation ( SOT ) , leading to diverse extrahepatic manifestations and chronic hepatitis with unfavorable outcomes .',
  'Hepatitis E outbreaks are a serious public health concern in developing countries .',
  'Hepatitis E virus ( HEV ) infection is an emerging disease with zoonotic transmission that represents a serious public health concern , especially in developing countries .',
  'Hepatitis E virus ( HEV ) is a serious public health problem .'],
 'caustic': ['Caustic ingestion is a serious medical problem affecting anywhere from 5,000 to 15,000 persons per year .',
  "Caustic stenosis is a serious problem in children due to its complicated resolution and implications in important areas like nutrition , as well as the child 's tolerance to the measures taken to correct them .",
  'Caustic esophageal burn is a serious problem in pediatric surgery .',
  'Caustic ingestion is a serious medical problem with a variety of clinical presentations and a complicated clinical course .',
  'Caustic substance ingestion ( CSI ) is a serious medical problem with potentially devastating short- and long-term consequences .',
  'The ingestion of caustic substances represents a serious problem , often with devastating consequences on the esophagus and the stomach .',
  'Corrosive esophageal injury due to accidental ingestion is a serious clinical problem in children particularly in developing countries .',
  'Caustic esophagitis is a serious clinical problem and many agents are currently tried out in many experimental models .',
  'The ingestion of caustic substances can represent a serious medical problem in children .',
  'Oesophageal strictures developing after caustic ingestion in children are a serious problem , and several protocols to prevent stricture formation have been proposed .',
  'the ingestion of chemical agents , of caustic nature , represents a serious problem for clinical toxicology .'],
 'unintended': ['In Pakistan , like other developing countries , utilization of family planning methods is a serious public health concern among married women .',
  'Unintended pregnancy is a serious problem in the United States .',
  'Unplanned pregnancy is a serious and frequently occurring problem among ADAF women , with many opportunities for prevention .',
  'Lack of local data on pregnancy intendedness poses a serious problem for those responsible for regional program development and evaluation .',
  'In the United States , unintended pregnancy is a serious health , social , and economic concern .',
  'Unintended pregnancy is a serious concern in reproductive health which needs to be addressed .',
  'Overall , 34 % of women and 31 % of men felt that prematurity is a common problem in the United States , and 38 % of women and 25 % of men believed prematurity to be a serious problem in the United States .',
  'Whether or not increased prevalence of oral contraceptive use in developing countries is associated with increased morbidity and mortality from circulatory system diseases is a serious concern for health and family planning administrators .',
  'Unplanned pregnancies are a serious health concern in Wisconsin .',
  'A greater percentage would terminate a pregnancy for a serious medical problem .',
  'Unwanted pregnancy causes a serious health , economic , and social problem to the woman and her family .',
  'Analysis of data from the 1988 National Survey of Family Growth -- corrected for the underreporting of abortion -- reveals that contraceptive failure during the first year of use remains a serious problem in the United States , contributing substantially to unintended pregnancy .',
  'Unintended pregnancy is a serious problem in the United States .'],
 'contraceptive': ['In Pakistan , like other developing countries , utilization of family planning methods is a serious public health concern among married women .',
  'Unintended pregnancy is a serious problem in the United States .',
  'Unplanned pregnancy is a serious and frequently occurring problem among ADAF women , with many opportunities for prevention .',
  'Lack of local data on pregnancy intendedness poses a serious problem for those responsible for regional program development and evaluation .',
  'In the United States , unintended pregnancy is a serious health , social , and economic concern .',
  'Unintended pregnancy is a serious concern in reproductive health which needs to be addressed .',
  'Overall , 34 % of women and 31 % of men felt that prematurity is a common problem in the United States , and 38 % of women and 25 % of men believed prematurity to be a serious problem in the United States .',
  'Whether or not increased prevalence of oral contraceptive use in developing countries is associated with increased morbidity and mortality from circulatory system diseases is a serious concern for health and family planning administrators .',
  'Unplanned pregnancies are a serious health concern in Wisconsin .',
  'A greater percentage would terminate a pregnancy for a serious medical problem .',
  'Unwanted pregnancy causes a serious health , economic , and social problem to the woman and her family .',
  'Analysis of data from the 1988 National Survey of Family Growth -- corrected for the underreporting of abortion -- reveals that contraceptive failure during the first year of use remains a serious problem in the United States , contributing substantially to unintended pregnancy .',
  'Unintended pregnancy is a serious problem in the United States .'],
 'prematurity': ['In Pakistan , like other developing countries , utilization of family planning methods is a serious public health concern among married women .',
  'Unintended pregnancy is a serious problem in the United States .',
  'Unplanned pregnancy is a serious and frequently occurring problem among ADAF women , with many opportunities for prevention .',
  'Lack of local data on pregnancy intendedness poses a serious problem for those responsible for regional program development and evaluation .',
  'In the United States , unintended pregnancy is a serious health , social , and economic concern .',
  'Unintended pregnancy is a serious concern in reproductive health which needs to be addressed .',
  'Overall , 34 % of women and 31 % of men felt that prematurity is a common problem in the United States , and 38 % of women and 25 % of men believed prematurity to be a serious problem in the United States .',
  'Whether or not increased prevalence of oral contraceptive use in developing countries is associated with increased morbidity and mortality from circulatory system diseases is a serious concern for health and family planning administrators .',
  'Unplanned pregnancies are a serious health concern in Wisconsin .',
  'A greater percentage would terminate a pregnancy for a serious medical problem .',
  'Unwanted pregnancy causes a serious health , economic , and social problem to the woman and her family .',
  'Analysis of data from the 1988 National Survey of Family Growth -- corrected for the underreporting of abortion -- reveals that contraceptive failure during the first year of use remains a serious problem in the United States , contributing substantially to unintended pregnancy .',
  'Unintended pregnancy is a serious problem in the United States .'],
 'unplanned': ['In Pakistan , like other developing countries , utilization of family planning methods is a serious public health concern among married women .',
  'Unintended pregnancy is a serious problem in the United States .',
  'Unplanned pregnancy is a serious and frequently occurring problem among ADAF women , with many opportunities for prevention .',
  'Lack of local data on pregnancy intendedness poses a serious problem for those responsible for regional program development and evaluation .',
  'In the United States , unintended pregnancy is a serious health , social , and economic concern .',
  'Unintended pregnancy is a serious concern in reproductive health which needs to be addressed .',
  'Overall , 34 % of women and 31 % of men felt that prematurity is a common problem in the United States , and 38 % of women and 25 % of men believed prematurity to be a serious problem in the United States .',
  'Whether or not increased prevalence of oral contraceptive use in developing countries is associated with increased morbidity and mortality from circulatory system diseases is a serious concern for health and family planning administrators .',
  'Unplanned pregnancies are a serious health concern in Wisconsin .',
  'A greater percentage would terminate a pregnancy for a serious medical problem .',
  'Unwanted pregnancy causes a serious health , economic , and social problem to the woman and her family .',
  'Analysis of data from the 1988 National Survey of Family Growth -- corrected for the underreporting of abortion -- reveals that contraceptive failure during the first year of use remains a serious problem in the United States , contributing substantially to unintended pregnancy .',
  'Unintended pregnancy is a serious problem in the United States .'],
 'recommendation': ['On call . I hope you can help me understand a troubling and embarrassing problem .',
  'This is a serious problem and , therefore , requires immediate attention .',
  'is a serious concern .',
  'This is a serious problem .',
  'This is a severe problem that requires sound scientific solutions .',
  'This represents a serious health problem .',
  'is a serious problem .',
  'This means a severe problem in communication .',
  'This is a serious problem .',
  'This has been a serious concern .',
  'Whether this recommendation is implemented in daily practices represents a serious concern .',
  'This is a serious problem to overcome .',
  'This is a serious problem .',
  'This could be a serious problem .'],
 'call': ['On call . I hope you can help me understand a troubling and embarrassing problem .',
  'This is a serious problem and , therefore , requires immediate attention .',
  'is a serious concern .',
  'This is a serious problem .',
  'This is a severe problem that requires sound scientific solutions .',
  'This represents a serious health problem .',
  'is a serious problem .',
  'This means a severe problem in communication .',
  'This is a serious problem .',
  'This has been a serious concern .',
  'Whether this recommendation is implemented in daily practices represents a serious concern .',
  'This is a serious problem to overcome .',
  'This is a serious problem .',
  'This could be a serious problem .'],
 'communication': ['On call . I hope you can help me understand a troubling and embarrassing problem .',
  'This is a serious problem and , therefore , requires immediate attention .',
  'is a serious concern .',
  'This is a serious problem .',
  'This is a severe problem that requires sound scientific solutions .',
  'This represents a serious health problem .',
  'is a serious problem .',
  'This means a severe problem in communication .',
  'This is a serious problem .',
  'This has been a serious concern .',
  'Whether this recommendation is implemented in daily practices represents a serious concern .',
  'This is a serious problem to overcome .',
  'This is a serious problem .',
  'This could be a serious problem .'],
 'practices': ['On call . I hope you can help me understand a troubling and embarrassing problem .',
  'This is a serious problem and , therefore , requires immediate attention .',
  'is a serious concern .',
  'This is a serious problem .',
  'This is a severe problem that requires sound scientific solutions .',
  'This represents a serious health problem .',
  'is a serious problem .',
  'This means a severe problem in communication .',
  'This is a serious problem .',
  'This has been a serious concern .',
  'Whether this recommendation is implemented in daily practices represents a serious concern .',
  'This is a serious problem to overcome .',
  'This is a serious problem .',
  'This could be a serious problem .'],
 'solutions': ['On call . I hope you can help me understand a troubling and embarrassing problem .',
  'This is a serious problem and , therefore , requires immediate attention .',
  'is a serious concern .',
  'This is a serious problem .',
  'This is a severe problem that requires sound scientific solutions .',
  'This represents a serious health problem .',
  'is a serious problem .',
  'This means a severe problem in communication .',
  'This is a serious problem .',
  'This has been a serious concern .',
  'Whether this recommendation is implemented in daily practices represents a serious concern .',
  'This is a serious problem to overcome .',
  'This is a serious problem .',
  'This could be a serious problem .'],
 'scientific': ['On call . I hope you can help me understand a troubling and embarrassing problem .',
  'This is a serious problem and , therefore , requires immediate attention .',
  'is a serious concern .',
  'This is a serious problem .',
  'This is a severe problem that requires sound scientific solutions .',
  'This represents a serious health problem .',
  'is a serious problem .',
  'This means a severe problem in communication .',
  'This is a serious problem .',
  'This has been a serious concern .',
  'Whether this recommendation is implemented in daily practices represents a serious concern .',
  'This is a serious problem to overcome .',
  'This is a serious problem .',
  'This could be a serious problem .']}

import json

with open("full_topic_triples.json", "w") as f:
    json.dump(td, f)

Hierachy by source text overlap

#if there's overlap of t1 and t2 t1 is parent if t2 has less of the sources (and 80%+) of t2 sources are in t1 (otherwise duplicate or not that realted))

def sources_relation(s1, s2, min_overlap=0.7):
    s1 = set(s1)
    s2 = set(s2)
    l1 = len(s1)
    l2 = len(s2)

    common = s1.intersection(s2) #order doesn't matter
    
#     cl1 = len(s1.intersect(common))
#     cl2 = len(s2.intersect(common))
    
    relation="TBA"
    #if only a few sources are common and it's not all/most of one topics sources then -> different ideas
    #if many are common and one topic is much bigger, the smaller is a subtopic
    #if almost all are common and there's 50:50 or 30:70 split then they are duplicates
    #either unrelated, duplicate, or hypernomy
    
    cl = len(common)

    ol2 = cl/l2
    ol1 = cl/l1
    if l1 > l2:
        ol = ol2
    else:
        ol = ol1
    
    if ol < min_overlap: #little in common (one topic is enough to decide)
        relation="different"
        
        #-- comparative
    if ol > min_overlap: #if lots of overlap
        if l2/l1 < 8/10:
            relation="child"
            
            #TODO: use permutations and then filter out duplicates / differents ... (only child left)
        elif l1/l2 < 8/10:
            relation="parent"
        else: #approx similar size
            #topics similar size and much of overlap (synonyms)
            relation = "duplicates"
    
    return relation

from itertools import combinations

topic_pairs = combinations(td.keys(), 2)
result = [(t1, t2, sources_relation(td[t1], td[t2]) ) for t1,t2 in topic_pairs]

Building the Tree

triples = [r for r in result if r[2] == "child" or r[2] == "parent"]

triples[:8], len(result), len(triples)

([('reperfusion', 'ischemia', 'parent'),
  ('reperfusion', 'ischemic', 'child'),
  ('reperfusion', 'myocardial', 'child'),
  ('reperfusion', 'cerebral', 'child'),
  ('reperfusion', 'perfusion', 'child'),
  ('reperfusion', 'neurons', 'child'),
  ('transplantation', 'nephrotoxicity', 'child'),
  ('transplantation', 'cyclosporine', 'child')],
 378885,
 449)

def tree_has_topic(topic, tree):
    return len([k for k in FlatterDict(tree).keys() if topic in k]) > 0

def get_leaves(topic, triples):
    node = {}
    node[topic] = {"children": []}
    #topic = node
    for t in triples:
        if (t[0] == topic and t[2] == "child") and not tree_has_topic(t[1], triples): #":or (t[1] == topic and t[2] == "parent")) 
            node[topic]["children"] += [get_leaves(t[1], triples)] 
            
            # TODO: flatten and check if key is already in 
    if len(node[topic]["children"]) == 0: # leave
        return node
    return node

x = "reperfusion"
[t for t in triples if t[0] == x or t[1] == x]

[('reperfusion', 'ischemia', 'parent'),
 ('reperfusion', 'ischemic', 'child'),
 ('reperfusion', 'myocardial', 'child'),
 ('reperfusion', 'cerebral', 'child'),
 ('reperfusion', 'perfusion', 'child'),
 ('reperfusion', 'neurons', 'child')]

from flatdict import FlatDict, FlatterDict
y = get_leaves("ischemia", triples)

y

{'ischemia': {'children': [{'vascular': {'children': []}},
   {'limb': {'children': []}},
   {'ischemic': {'children': [{'myocardial': {'children': []}},
      {'cerebral': {'children': []}},
      {'perfusion': {'children': []}},
      {'neurons': {'children': []}}]}},
   {'myocardial': {'children': []}},
   {'cerebral': {'children': []}},
   {'perfusion': {'children': []}},
   {'neurons': {'children': []}},
   {'mesenteric': {'children': []}},
   {'ischaemia': {'children': []}},
   {'intestine': {'children': []}}]}}

triples[:20]

[('reperfusion', 'ischemia', 'parent'),
 ('reperfusion', 'ischemic', 'child'),
 ('reperfusion', 'myocardial', 'child'),
 ('reperfusion', 'cerebral', 'child'),
 ('reperfusion', 'perfusion', 'child'),
 ('reperfusion', 'neurons', 'child'),
 ('transplantation', 'nephrotoxicity', 'child'),
 ('transplantation', 'cyclosporine', 'child'),
 ('transplantation', 'cyclosporin', 'child'),
 ('transplantation', 'allograft', 'child'),
 ('transplantation', 'gvhd', 'child'),
 ('transplantation', 'shortage', 'child'),
 ('transplantation', 'donor', 'child'),
 ('transplantation', 'donors', 'child'),
 ('transplantation', 'graft', 'child'),
 ('transplantation', 'transplant', 'child'),
 ('transplantation', 'interferon', 'child'),
 ('ischemia', 'vascular', 'child'),
 ('ischemia', 'limb', 'child'),
 ('ischemia', 'ischemic', 'child')]

trees = {}
for triple in triples:
    #every entity first get's it's children attached before attaching to parent
    topic = triple[0]
    if not trees.get(topic):
        trees[topic] = get_leaves(topic, triples)[topic]

trees

{'reperfusion': {'children': [{'ischemic': {'children': [{'myocardial': {'children': []}},
      {'cerebral': {'children': []}},
      {'perfusion': {'children': []}},
      {'neurons': {'children': []}}]}},
   {'myocardial': {'children': []}},
   {'cerebral': {'children': []}},
   {'perfusion': {'children': []}},
   {'neurons': {'children': []}}]},
 'transplantation': {'children': [{'nephrotoxicity': {'children': []}},
   {'cyclosporine': {'children': []}},
   {'cyclosporin': {'children': []}},
   {'allograft': {'children': []}},
   {'gvhd': {'children': []}},
   {'shortage': {'children': []}},
   {'donor': {'children': []}},
   {'donors': {'children': []}},
   {'graft': {'children': []}},
   {'transplant': {'children': []}},
   {'interferon': {'children': []}}]},
 'ischemia': {'children': [{'vascular': {'children': []}},
   {'limb': {'children': []}},
   {'ischemic': {'children': [{'myocardial': {'children': []}},
      {'cerebral': {'children': []}},
      {'perfusion': {'children': []}},
      {'neurons': {'children': []}}]}},
   {'myocardial': {'children': []}},
   {'cerebral': {'children': []}},
   {'perfusion': {'children': []}},
   {'neurons': {'children': []}},
   {'mesenteric': {'children': []}},
   {'ischaemia': {'children': []}},
   {'intestine': {'children': []}}]},
 'diabetes': {'children': [{'dkd': {'children': []}},
   {'microvascular': {'children': []}},
   {'mexico': {'children': []}},
   {'indigenous': {'children': []}}]},
 'gastrointestinal': {'children': []},
 'intestinal': {'children': [{'eosinophilic': {'children': []}},
   {'bowel': {'children': []}},
   {'distention': {'children': []}},
   {'hypopigmentation': {'children': []}},
   {'hypomelanosis': {'children': []}},
   {'mesenteric': {'children': []}},
   {'ischaemia': {'children': []}},
   {'intestine': {'children': []}}]},
 'stress': {'children': [{'ptsd': {'children': []}},
   {'posttraumatic': {'children': []}}]},
 'adhesions': {'children': []},
 'postoperative': {'children': [{'adhesion': {'children': []}},
   {'nausea': {'children': []}},
   {'vomiting': {'children': []}},
   {'epidural': {'children': []}},
   {'analgesia': {'children': []}},
   {'thoracotomy': {'children': []}}]},
 'pain': {'children': [{'neuropathic': {'children': []}},
   {'neuropathy': {'children': []}}]},
 'rhinosinusitis': {'children': []},
 'respiratory': {'children': [{'nasal': {'children': []}},
   {'distress': {'children': []}},
   {'ards': {'children': []}},
   {'ventilation': {'children': []}},
   {'surfactant': {'children': []}},
   {'antenatal': {'children': []}},
   {'newborn': {'children': []}},
   {'bronchopulmonary': {'children': []}}]},
 'bone': {'children': [{'osteoporosis': {'children': [{'glucocorticoid': {'children': []}},
      {'steroid': {'children': []}}]}},
   {'metastases': {'children': []}},
   {'metastatic': {'children': []}}]},
 'depression': {'children': [{'depressive': {'children': []}}]},
 'depressive': {'children': []},
 'disorder': {'children': [{'borderline': {'children': []}},
   {'personality': {'children': []}},
   {'bpd': {'children': []}},
   {'bipolar': {'children': []}},
   {'affective': {'children': []}},
   {'ptsd': {'children': []}},
   {'posttraumatic': {'children': []}}]},
 'diabetic': {'children': [{'ulceration': {'children': []}},
   {'dkd': {'children': []}},
   {'microvascular': {'children': []}}]},
 'ulcers': {'children': [{'ulceration': {'children': []}},
   {'ulcer': {'children': [{'sores': {'children': []}},
      {'pus': {'children': []}},
      {'leg': {'children': []}}]}},
   {'sores': {'children': []}},
   {'pus': {'children': []}},
   {'leg': {'children': []}}]},
 'nausea': {'children': []},
 'vomiting': {'children': []},
 'chemotherapy': {'children': [{'multidrug': {'children': []}},
   {'neutropenia': {'children': []}},
   {'hematologic': {'children': []}},
   {'myelotoxic': {'children': []}},
   {'corynebacterium': {'children': []}}]},
 'medication': {'children': [{'adherence': {'children': []}},
   {'prescribed': {'children': []}}]},
 'mental': {'children': [{'borderline': {'children': []}},
   {'personality': {'children': []}},
   {'bpd': {'children': []}},
   {'bipolar': {'children': []}},
   {'affective': {'children': []}}]},
 'distress': {'children': []},
 'ards': {'children': []},
 'lung': {'children': [{'ventilation': {'children': []}},
   {'fibrosis': {'children': []}},
   {'ipf': {'children': []}},
   {'myofibroblasts': {'children': []}},
   {'idiopathic': {'children': []}},
   {'epithelial': {'children': []}}]},
 'cardiac': {'children': [{'scd': {'children': []}},
   {'death': {'children': []}},
   {'atrial': {'children': []}},
   {'fibrillation': {'children': []}},
   {'arrhythmia': {'children': []}}]},
 'esophageal': {'children': [{'esophagectomy': {'children': []}},
   {'caustic': {'children': []}}]},
 'osteoporosis': {'children': [{'glucocorticoid': {'children': []}},
   {'steroid': {'children': []}}]},
 'fractures': {'children': [{'fracture': {'children': []}},
   {'femoral': {'children': []}}]},
 'postpartum': {'children': []},
 'mothers': {'children': []},
 'postnatal': {'children': [{'surfactant': {'children': []}},
   {'antenatal': {'children': []}},
   {'newborn': {'children': []}},
   {'bronchopulmonary': {'children': []}}]},
 'uti': {'children': []},
 'urinary': {'children': [{'utis': {'children': []}},
   {'urine': {'children': []}},
   {'prostatectomy': {'children': []}},
   {'extraperitoneal': {'children': []}},
   {'lrpe': {'children': []}},
   {'transperitoneal': {'children': []}}]},
 'utis': {'children': []},
 'coli': {'children': [{'escherichia': {'children': []}}]},
 'endodontic': {'children': []},
 'dental': {'children': [{'caries': {'children': []}}]},
 'incontinence': {'children': [{'fecal': {'children': []}},
   {'faecal': {'children': []}},
   {'urine': {'children': []}},
   {'prostatectomy': {'children': []}},
   {'extraperitoneal': {'children': []}},
   {'lrpe': {'children': []}},
   {'transperitoneal': {'children': []}}]},
 'hiv': {'children': [{'coinfection': {'children': []}}]},
 'immunodeficiency': {'children': [{'coinfection': {'children': []}}]},
 'liver': {'children': [{'fatty': {'children': []}},
   {'alcoholic': {'children': []}},
   {'nonalcoholic': {'children': []}},
   {'steatohepatitis': {'children': []}},
   {'hepatotoxicity': {'children': []}},
   {'acetaminophen': {'children': []}},
   {'graft': {'children': []}},
   {'transplant': {'children': []}},
   {'interferon': {'children': []}}]},
 'surfactant': {'children': []},
 'antenatal': {'children': []},
 'neonatal': {'children': [{'newborn': {'children': []}},
   {'bronchopulmonary': {'children': []}},
   {'tetanus': {'children': []}},
   {'pertussis': {'children': []}}]},
 'infants': {'children': [{'newborn': {'children': []}},
   {'bronchopulmonary': {'children': []}},
   {'asphyxia': {'children': []}},
   {'preterm': {'children': []}}]},
 'tbi': {'children': []},
 'traumatic': {'children': []},
 'brain': {'children': [{'cerebral': {'children': []}},
   {'perfusion': {'children': []}},
   {'neurons': {'children': []}}]},
 'radiation': {'children': [{'radiotherapy': {'children': []}}]},
 'carcinoma': {'children': [{'hcc': {'children': []}},
   {'hepatocellular': {'children': []}}]},
 'diarrhea': {'children': []},
 'diarrheal': {'children': []},
 'diarrhoea': {'children': [{'difficile': {'children': []}},
   {'clostridium': {'children': []}},
   {'bacterium': {'children': []}}]},
 'allergy': {'children': [{'allergies': {'children': []}},
   {'allergic': {'children': []}},
   {'anaphylaxis': {'children': []}}]},
 'spinal': {'children': [{'lumbar': {'children': []}},
   {'degenerative': {'children': []}},
   {'spine': {'children': []}}]},
 'injury': {'children': [{'acute': {'children': []}}]},
 'laparoscopic': {'children': [{'hernia': {'children': []}},
   {'hernias': {'children': []}},
   {'incisional': {'children': []}},
   {'abdominal': {'children': []}}]},
 'prostate': {'children': [{'pca': {'children': []}},
   {'androgen': {'children': []}},
   {'prostatectomy': {'children': []}},
   {'extraperitoneal': {'children': []}},
   {'lrpe': {'children': []}},
   {'transperitoneal': {'children': []}}]},
 'pneumoniae': {'children': [{'kpc': {'children': []}},
   {'crkp': {'children': []}},
   {'nicu': {'children': []}}]},
 'cleft': {'children': []},
 'palate': {'children': []},
 'lip': {'children': []},
 'clefts': {'children': []},
 'congenital': {'children': [{'syphilis': {'children': []}}]},
 'tuberculosis': {'children': [{'coinfection': {'children': []}},
   {'mycobacterium': {'children': []}},
   {'mycobacterial': {'children': []}},
   {'strains': {'children': []}}]},
 'tb': {'children': [{'coinfection': {'children': []}}]},
 'malnutrition': {'children': [{'elderly': {'children': []}},
   {'undernutrition': {'children': []}}]},
 'intracerebral': {'children': []},
 'ich': {'children': []},
 'hemorrhage': {'children': [{'subarachnoid': {'children': []}},
   {'aneurysmal': {'children': []}}]},
 'suicidal': {'children': [{'harm': {'children': []}},
   {'prisoners': {'children': []}}]},
 'workplace': {'children': [{'employees': {'children': []}},
   {'workplaces': {'children': []}}]},
 'adolescents': {'children': [{'adolescent': {'children': []}}]},
 'dengue': {'children': [{'denv': {'children': []}}]},
 'drinking': {'children': []},
 'alcohol': {'children': [{'college': {'children': []}},
   {'alcoholism': {'children': []}},
   {'fetal': {'children': []}}]},
 'pollution': {'children': [{'china': {'children': []}},
   {'haze': {'children': []}}]},
 'ischemic': {'children': [{'myocardial': {'children': []}},
   {'cerebral': {'children': []}},
   {'perfusion': {'children': []}},
   {'neurons': {'children': []}}]},
 'cartilage': {'children': []},
 'osteoarthritis': {'children': []},
 'knee': {'children': [{'articular': {'children': []}},
   {'nerve': {'children': []}},
   {'peroneal': {'children': []}},
   {'neurolysis': {'children': []}}]},
 'ckd': {'children': []},
 'kidney': {'children': [{'nephrotoxicity': {'children': []}},
   {'cyclosporine': {'children': []}},
   {'cyclosporin': {'children': []}},
   {'acute': {'children': []}}]},
 'renal': {'children': [{'nephrotoxicity': {'children': []}},
   {'cyclosporine': {'children': []}},
   {'cyclosporin': {'children': []}}]},
 'falls': {'children': [{'falling': {'children': []}}]},
 'fall': {'children': [{'falling': {'children': []}}]},
 'abortion': {'children': [{'clandestine': {'children': []}},
   {'abortions': {'children': []}},
   {'misoprostol': {'children': []}},
   {'caesareans': {'children': []}},
   {'conceive': {'children': []}}]},
 'nephropathy': {'children': [{'dkd': {'children': []}},
   {'microvascular': {'children': []}},
   {'thrombectomy': {'children': []}}]},
 'peritoneal': {'children': []},
 'dialysis': {'children': [{'peritonitis': {'children': []}},
   {'hemodialysis': {'children': []}},
   {'haemodialysis': {'children': []}},
   {'hypotension': {'children': []}}]},
 'addiction': {'children': [{'internet': {'children': []}},
   {'gaming': {'children': []}},
   {'games': {'children': []}}]},
 'amr': {'children': []},
 'antimicrobial': {'children': [{'gonorrhoeae': {'children': []}},
   {'gonorrhoea': {'children': []}},
   {'gonorrhea': {'children': []}},
   {'gonococcal': {'children': []}}]},
 'dating': {'children': []},
 'stalking': {'children': []},
 'violence': {'children': [{'relationships': {'children': []}},
   {'women': {'children': []}},
   {'gender': {'children': []}},
   {'ipv': {'children': []}},
   {'domestic': {'children': []}},
   {'intimate': {'children': []}}]},
 'bullying': {'children': [{'workplaces': {'children': []}},
   {'victimization': {'children': []}}]},
 'wounds': {'children': []},
 'deficiency': {'children': [{'vitamin': {'children': []}},
   {'iodine': {'children': []}},
   {'pregnant': {'children': []}},
   {'idd': {'children': []}}]},
 'anaemia': {'children': [{'anemia': {'children': []}}]},
 'antibodies': {'children': [{'fviii': {'children': []}},
   {'hemophilia': {'children': []}},
   {'haemophilia': {'children': []}},
   {'inhibitor': {'children': []}}]},
 'hbv': {'children': []},
 'hepatitis': {'children': [{'hcv': {'children': [{'graft': {'children': []}},
      {'transplant': {'children': []}},
      {'interferon': {'children': []}}]}},
   {'viral': {'children': []}},
   {'graft': {'children': []}},
   {'transplant': {'children': []}},
   {'interferon': {'children': []}},
   {'hev': {'children': []}}]},
 'waste': {'children': []},
 'disposal': {'children': [{'sludge': {'children': []}},
   {'sewage': {'children': []}},
   {'wastewater': {'children': []}}]},
 'foodborne': {'children': [{'monocytogenes': {'children': []}},
   {'listeria': {'children': []}},
   {'listeriosis': {'children': []}}]},
 'aging': {'children': [{'multimorbidity': {'children': []}}]},
 'pregnancy': {'children': [{'caesareans': {'children': []}},
   {'conceive': {'children': []}},
   {'fetal': {'children': []}},
   {'teenage': {'children': []}},
   {'pregnancies': {'children': []}},
   {'placental': {'children': []}},
   {'unintended': {'children': []}},
   {'contraceptive': {'children': []}},
   {'prematurity': {'children': []}},
   {'unplanned': {'children': []}}]},
 'leishmaniasis': {'children': [{'cutaneous': {'children': []}},
   {'morocco': {'children': []}},
   {'visceral': {'children': []}},
   {'leishmania': {'children': []}},
   {'brazil': {'children': []}}]},
 'nitrate': {'children': []},
 'nitrogen': {'children': []},
 'groundwater': {'children': [{'arsenic': {'children': []}}]},
 'hemodialysis': {'children': []},
 'haemodialysis': {'children': []},
 'hypotension': {'children': []},
 'thrombosis': {'children': [{'venous': {'children': []}},
   {'thromboembolism': {'children': []}},
   {'vein': {'children': []}}]},
 'aureus': {'children': [{'staphylococci': {'children': []}},
   {'mrsa': {'children': []}}]},
 'staphylococcus': {'children': [{'staphylococci': {'children': []}},
   {'mrsa': {'children': []}}]},
 'malaria': {'children': [{'falciparum': {'children': []}},
   {'chloroquine': {'children': []}},
   {'plasmodium': {'children': [{'artemisinin': {'children': []}},
      {'placental': {'children': []}}]}},
   {'artemisinin': {'children': []}},
   {'placental': {'children': []}}]},
 'hcv': {'children': [{'graft': {'children': []}},
   {'transplant': {'children': []}},
   {'interferon': {'children': []}}]},
 'milk': {'children': []},
 'dairy': {'children': [{'mastitis': {'children': []}}]},
 'lactamases': {'children': []},
 'lactamase': {'children': []},
 'pesticide': {'children': []},
 'pesticides': {'children': [{'organophosphorus': {'children': []}},
   {'organophosphate': {'children': []}},
   {'rodenticide': {'children': []}}]},
 'elder': {'children': []},
 'abuse': {'children': [{'neglect': {'children': []}},
   {'exploitation': {'children': []}}]},
 'neglect': {'children': []},
 'older': {'children': [{'exploitation': {'children': []}}]},
 'echinococcosis': {'children': []},
 'cystic': {'children': [{'echinococcus': {'children': []}},
   {'aeruginosa': {'children': []}},
   {'pseudomonas': {'children': []}}]},
 'plastic': {'children': []},
 'plastics': {'children': [{'microplastics': {'children': []}},
   {'microplastic': {'children': []}},
   {'nanoplastics': {'children': []}}]},
 'biofilm': {'children': [{'biofilms': {'children': []}}]},
 'soil': {'children': [{'soils': {'children': [{'cadmium': {'children': []}}]}},
   {'cadmium': {'children': []}},
   {'erosion': {'children': []}},
   {'land': {'children': []}},
   {'desertification': {'children': []}},
   {'salinity': {'children': []}},
   {'salinization': {'children': []}},
   {'salt': {'children': []}},
   {'arid': {'children': []}}]},
 'soils': {'children': [{'cadmium': {'children': []}}]},
 'venous': {'children': []},
 'thromboembolism': {'children': []},
 'vein': {'children': []},
 'embolism': {'children': [{'pe': {'children': []}},
   {'ctpa': {'children': []}},
   {'tomography': {'children': []}},
   {'diagnosis': {'children': []}}]},
 'ulcer': {'children': [{'sores': {'children': []}},
   {'pus': {'children': []}},
   {'leg': {'children': []}}]},
 'acinetobacter': {'children': []},
 'carbapenem': {'children': [{'carbapenemase': {'children': [{'kpc': {'children': []}},
      {'crkp': {'children': []}},
      {'nicu': {'children': []}}]}},
   {'kpc': {'children': []}},
   {'crkp': {'children': []}},
   {'nicu': {'children': []}}]},
 'eutrophication': {'children': [{'freshwaters': {'children': []}},
   {'tributaries': {'children': []}},
   {'ecosystems': {'children': []}},
   {'phosphorus': {'children': []}},
   {'phosphate': {'children': []}},
   {'phosphogypsum': {'children': []}},
   {'farmlands': {'children': []}}]},
 'denv': {'children': []},
 'virus': {'children': [{'hev': {'children': []}}]},
 'copd': {'children': []},
 'pulmonary': {'children': [{'pe': {'children': []}},
   {'ctpa': {'children': []}},
   {'tomography': {'children': []}},
   {'diagnosis': {'children': []}},
   {'fibrosis': {'children': []}},
   {'ipf': {'children': []}},
   {'myofibroblasts': {'children': []}},
   {'idiopathic': {'children': []}},
   {'epithelial': {'children': []}}]},
 'fever': {'children': [{'typhoid': {'children': []}},
   {'typhus': {'children': []}}]},
 'pe': {'children': []},
 'ctpa': {'children': []},
 'angiography': {'children': [{'tomography': {'children': []}},
   {'diagnosis': {'children': []}},
   {'subarachnoid': {'children': []}},
   {'aneurysmal': {'children': []}}]},
 'falciparum': {'children': []},
 'chloroquine': {'children': []},
 'plasmodium': {'children': [{'artemisinin': {'children': []}},
   {'placental': {'children': []}}]},
 'anabolic': {'children': []},
 'doping': {'children': []},
 'androgenic': {'children': []},
 'steroids': {'children': []},
 'sports': {'children': [{'sport': {'children': []}},
   {'concussion': {'children': []}},
   {'concussions': {'children': []}},
   {'athletes': {'children': []}}]},
 'poisoning': {'children': [{'poisonings': {'children': []}},
   {'organophosphorus': {'children': []}},
   {'organophosphate': {'children': []}},
   {'rodenticide': {'children': []}},
   {'delphinium': {'children': []}},
   {'larkspur': {'children': []}},
   {'rangelands': {'children': []}},
   {'locoweed': {'children': []}},
   {'poisonous': {'children': []}}]},
 'carbapenemase': {'children': [{'kpc': {'children': []}},
   {'crkp': {'children': []}},
   {'nicu': {'children': []}}]},
 'meningococcal': {'children': []},
 'meningitidis': {'children': []},
 'neisseria': {'children': [{'gonorrhoeae': {'children': []}},
   {'gonorrhoea': {'children': []}},
   {'gonorrhea': {'children': []}},
   {'gonococcal': {'children': []}}]},
 'aspiration': {'children': []},
 'ingestion': {'children': [{'caustic': {'children': []}}]},
 'hospitals': {'children': [{'overcrowding': {'children': []}},
   {'emergency': {'children': []}},
   {'department': {'children': []}}]}}

for vs in trees["reperfusion"].values():
    for v in vs:
        print([*v.keys()])

['ischemic']
['myocardial']
['cerebral']
['perfusion']
['neurons']

def write(p, depth=0, indent=4):
    if p==None:
        return
    # here we multiply the level by the number of indents
    # and then you multiply that number with a space character
    # which will magically show as that number of spaces.
    print("{}{}".format(" "*(indent*depth), p))
    if p.children!=None:
        # then you do not need your print(…, end='') hack
        # simply increase the depth
        write(p.children, depth=depth+1, indent=indent)

def walk(node):
    """ iterate tree in pre-order depth-first search order """
   # yield node
    for child in node.children:
        print(child)
        for n in walk(child):
            yield n

def text_node(node_key, tree):
    text = node_key
    children = tree[node_key].get("children")
    if not children:
        text += "\n\t"
    for child in children:
        text += "\t -->"
        text += text_node([*child.keys()][0], child)
        
    return text

trees["reperfusion"]

{'children': [{'ischemic': {'children': [{'myocardial': {'children': []}},
     {'cerebral': {'children': []}},
     {'perfusion': {'children': []}},
     {'neurons': {'children': []}}]}},
  {'myocardial': {'children': []}},
  {'cerebral': {'children': []}},
  {'perfusion': {'children': []}},
  {'neurons': {'children': []}}]}

trees.keys()

dict_keys(['reperfusion', 'transplantation', 'ischemia', 'diabetes', 'gastrointestinal', 'intestinal', 'stress', 'adhesions', 'postoperative', 'pain', 'rhinosinusitis', 'respiratory', 'bone', 'depression', 'depressive', 'disorder', 'diabetic', 'ulcers', 'nausea', 'vomiting', 'chemotherapy', 'medication', 'mental', 'distress', 'ards', 'lung', 'cardiac', 'esophageal', 'osteoporosis', 'fractures', 'postpartum', 'mothers', 'postnatal', 'uti', 'urinary', 'utis', 'coli', 'endodontic', 'dental', 'incontinence', 'hiv', 'immunodeficiency', 'liver', 'surfactant', 'antenatal', 'neonatal', 'infants', 'tbi', 'traumatic', 'brain', 'radiation', 'carcinoma', 'diarrhea', 'diarrheal', 'diarrhoea', 'allergy', 'spinal', 'injury', 'laparoscopic', 'prostate', 'pneumoniae', 'cleft', 'palate', 'lip', 'clefts', 'congenital', 'tuberculosis', 'tb', 'malnutrition', 'intracerebral', 'ich', 'hemorrhage', 'suicidal', 'workplace', 'adolescents', 'dengue', 'drinking', 'alcohol', 'pollution', 'ischemic', 'cartilage', 'osteoarthritis', 'knee', 'ckd', 'kidney', 'renal', 'falls', 'fall', 'abortion', 'nephropathy', 'peritoneal', 'dialysis', 'addiction', 'amr', 'antimicrobial', 'dating', 'stalking', 'violence', 'bullying', 'wounds', 'deficiency', 'anaemia', 'antibodies', 'hbv', 'hepatitis', 'waste', 'disposal', 'foodborne', 'aging', 'pregnancy', 'leishmaniasis', 'nitrate', 'nitrogen', 'groundwater', 'hemodialysis', 'haemodialysis', 'hypotension', 'thrombosis', 'aureus', 'staphylococcus', 'malaria', 'hcv', 'milk', 'dairy', 'lactamases', 'lactamase', 'pesticide', 'pesticides', 'elder', 'abuse', 'neglect', 'older', 'echinococcosis', 'cystic', 'plastic', 'plastics', 'biofilm', 'soil', 'soils', 'venous', 'thromboembolism', 'vein', 'embolism', 'ulcer', 'acinetobacter', 'carbapenem', 'eutrophication', 'denv', 'virus', 'copd', 'pulmonary', 'fever', 'pe', 'ctpa', 'angiography', 'falciparum', 'chloroquine', 'plasmodium', 'anabolic', 'doping', 'androgenic', 'steroids', 'sports', 'poisoning', 'carbapenemase', 'meningococcal', 'meningitidis', 'neisseria', 'aspiration', 'ingestion', 'hospitals'])

t = """"""
for key in trees.keys():
    t += text_node(key, trees)

with open('topic_trees.txt', 'w') as f:
    print(t, file=f)

walk(trees["reperfusion"])

<generator object walk at 0x7fc1a325b150>

for topic, sources in td.items():
    #every combination gets overlaps

disease
inflammatory
gastrointestinal
esophageal
eosinophilic
diseases
disorders
depression
mental
health
suicide
stroke
disability
parkinson
pd
diabetes
diabetic
cardiovascular
myocardial
cancer
skin
infection
tuberculosis
rice
nursing
students
eating
children
overweight
adherence
obesity
medication